Responsiveness of obese Zucker rats to [D-Trp³⁴]-NPY supports the targeting of Y5 receptor for obesity treatment

References

• Beck B. 2000. Neuropeptides and obesity. Nutrition 16:916–923.
   PubMed Web of Science ®Google Scholar
• Beck B. 2006. Neuropeptide Y in normal eating and in genetic and dietary-induced obesity. Philos Trans R Soc Lond B Biol Sci 361:1159–1185.
   Google Scholar
• Beck B, Richy S, Dimitrov T, Stricker-Krongrad A. 2001. Opposite regulation of hypothalamic orexin and neuropeptide Y receptors and peptide expressions in obese Zucker rats. Biochem Biophys Res Commun 286:518–523.
   PubMed Web of Science ®Google Scholar
• Criscione L, Rigollier P, Batzl-Hartmann C, Rueger H, Stricker- Krongrad A, Wyss P, Brunner L, Whitebread S, Yamaguchi Y, Gerald C, Heurich RO, Walker MW, Chiesi M, Schilling W, Hofbauer KG, Levens N. 1998. Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y-5 receptor. J Clin Invest 102:2136–2145.
   PubMed Web of Science ®Google Scholar
• Della-Zuana O, Revereault L, Beck-Sickinger A, Monge A, Caignard DH, Fauchere JL, Henlin JM, Audinot V, Boutin JA, Chamorro S, Feletou M, Levens N. 2004. A potent and selective NPYY5 antagonist reduces food intake but not through blockade of the NPYY5 receptor. Int J Obesity 28:628–639.
   Web of Science ®Google Scholar
• Erondu N, Gantz I, Musser B, Suryawanshi S, Mallick M, Addy C, Cote J, Bray G, Fujioka K, Bays H, Hollander P, Sanabria- Bohorquez SM, Eng W, Langstrom B, Hargreaves RJ, Burns HD, Kanatani A, Fukami T, MacNeil DJ, Gottesdiener KM, Amatruda JM, Kaufman KD, Heymsfield SB. 2006. Neuropep-tide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults. Cell Metab 4:275–282.
   PubMed Web of Science ®Google Scholar
• Huang XF, Han M, Storlien LH. 2003. The level of NPY receptor mRNA expression in diet-induced obese and resistant mice. Mol Brain Res 115:21–28.
   PubMedGoogle Scholar
• Hwa JJ, Witten MB, Williams P, Ghibaudi L, Gao J, Salisbury BG, Mullins D, Hamud F, Strader CD, Parker EM. 1999. Activation of the NPYY5 receptor regulates both feeding and energy expenditure. Am J Physiol 277:R1428–R1434.
   Google Scholar
• Inui A. 1999. Neuropeptide Y feeding receptors: Are multiple subtypes involved? Trends Pharmacol Sci 20:43–46.
   PubMed Web of Science ®Google Scholar
• Ishihara A, Kanatani A, Mashiko S, Tanaka T, Hidaka M, Gomori A, Iwaasa H, Murai N, Egashira S, Murai T, Mitobe Y, Matsushita H, Okamoto O, Sato N, Jitsuoka M, Fukuroda T, Ohe T, Guan XM, MacNeil DJ, Vander-Ploegn LHT, Nishikibe M, Ishii Y, Ihara M, Fukami T. 2006a. A neuropeptide YY5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice. Proc Natl Acad Sci USA 103:7154–7158.
   PubMed Web of Science ®Google Scholar
• Ishihara A, Moriya M, MacNeil DJ, Fukami T, Kanatani A. 2006b. Neuropeptide Y receptors as targets of obesity treatment. Expert Opin Ther Pat 16:1701–1712.
   Web of Science ®Google Scholar
• Lecklin A, Lundell I, Salmela S, Mannisto PT, BeckSickinger AG, Larhammar D. 2003. Agonists for neuropeptide Y receptors Y-1 and Y-5 stimulate different phases of feeding in guinea pigs. Br J Pharmacol 139:1433–1440.
   PubMed Web of Science ®Google Scholar
• Mashiko S, Ishihara A, Iwaasa H, Sano H, Oda Z, Ito J, Yumoto M, Okawa M, Suzuki J, Fukuroda T, Jitsuoka M, Morin NR, Macneil DJ, Vander-Ploeg LHT, Ihara M, Fukami T, Kanatani A. 2003. Characterization ofneuropeptideY (NPY) Y5 receptor-mediated obesity in mice: Chronic intracerebroventricular infusion of D- Trp(34)NPY. Endocrinology 144:1793–1801.
   PubMed Web of Science ®Google Scholar
• McCarthy HD, McKibbin PE, Holloway B, Mayers R, Williams G. 1991. Hypothalamic neuropeptide-Y receptor characteristics and NPY-induced feeding responses in lean and obese Zucker rats. Life Sci 49:1491–1497.
   PubMed Web of Science ®Google Scholar
• McCrea K, Wisialowski T, Cabrele C, Church B, BeckSickinger A, Kraegen E, Herzog H. 2000. 2–36[K-4,RYYSA(19–23)]PP a novel Y5-receptor preferring ligand with strong stimulatory effect on food intake. Regul Pept 87:47–58.
   PubMed Web of Science ®Google Scholar
• Mullins D, Kirby D, Hwa J, Guzzi M, Rivier J, Parker E. 2001. Identification of potent and selective neuropeptide YY1 receptor agonists with orexigenic activity in vivo. Mol Pharmacol 60:534–540.
   PubMed Web of Science ®Google Scholar
• Parker EM, Balasubramaniam A, Guzzi M, Mullins DE, Salisbury BG, Sheriff S, Witten MB, Hwa JJ. 2000. [D-Trp(34)] neuropeptide Y is a potent and selective neuropeptide YY5 receptor agonist with dramatic effects on food intake. Peptides 21:393–399.
   Google Scholar
• Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, Walts B, Perusse L, Bouchard C. 2006. The human obesity gene map: The 2005 update. Obesity 14:529–644.
   PubMed Web of Science ®Google Scholar
• Stricker-Krongrad A, Beck B. 2004. Up-regulation of neuropeptide Y receptors in the hypothalamus of monosodium glutamate- lesioned Sprague-Dawley rats. Nutr Neurosci 7:241–245.
   PubMed Web of Science ®Google Scholar
• Stricker-Krongrad A, Max JP, Musse N, Nicolas JP, Burlet C, Beck B. 1994. Increased threshold concentrations of neuropeptide Y for a stimulatory effect on food intake in obese Zucker rats— changes in the microstructure of the feeding behavior. Brain Res 660:162–166.
   PubMed Web of Science ®Google Scholar
• Turnbull AV, Ellershaw L, Masters DJ, Birtles S, Boyer S, Carroll D, Clarkson P, Loxham SJG, McAulay P, Teague JL, Foote KM, Pease JE, Block MH. 2002. Selective antagonism of the NPYY5 receptor does not have a major effect on feeding in rats. Diabetes 51:2441–2449.
   PubMed Web of Science ®Google Scholar
• Wang C, Yang N, Wu S, Liu L, Sun X, Nie S. 2007. Difference of NPY and its receptor gene expressions between obesity and obesity-resistant rats in response to high-fat diet. Horm Metab Res 39:262–267.
   PubMed Web of Science ®Google Scholar
• Widdowson PS. 1997. Regionally-selective down-regulation ofNPY receptor subtypes in the obese Zucker rat. Relationship to the Y5 “feeding” receptor. Brain Res 758:17–25.
   Google Scholar
• Wyss P, Levens N, Stricker-Krongrad A. 1998a. Stimulation of feeding in lean but not in obese Zucker rats by a selective neuropeptideYY5 receptor agonist. Neuroreport 9:2675–2677.
   PubMed Web of Science ®Google Scholar
• Wyss P, Stricker-Krongrad A, Brunner L, Miller J, Crossthwaite A, Whitebread S, Criscione L. 1998b. The pharmacology of neuropeptide Y (NPY) receptor-mediated feeding in rats characterizes better Y5 than Y1, but not Y2 or Y4 subtypes. Regul Pept 75–6:363–371.
   Google Scholar