Acute effects of a wild green-oat (Avena sativa) extract on cognitive function in middle-aged adults: A double-blind, placebo-controlled, within-subjects trial

References

• Abascal K, Yarnell E. Nervine herbs for treating anxiety. Altern Complement Ther 2004;10(6):309–315. doi: 10.1089/act.2004.10.309
   Google Scholar
• Blumenthal M, Goldberg A, Brinckmann J. Herbal medicine. Expanded Commission E monographs: Integrative Medicine Communications; 2000.
   Google Scholar
• Moccetti T, Wullschleger C, Schmidt A, Aydogan C, Kreuter M. Bioactivity-based development of a wild green oat (Avena sativa L.) extract in support of mental health disorders. Zeitschrift für Phytotherapie 2006;27(S1):P24.
   Google Scholar
• Finberg JP. Update on the pharmacology of selective inhibitors of MAO-A and MAO-B: Focus on modulation of CNS monoamine neurotransmitter release. Pharmacol Ther 2014;143(2):133–152. doi: 10.1016/j.pharmthera.2014.02.010
   PubMed Web of Science ®Google Scholar
• Zhang K, Ibrahim P, Gillette S, Bollag G. Phosphodiesterase-4 as a potential drug target. Expert Opin Ther Tar 2005;9(6):1283. doi: 10.1517/14728222.9.6.1283
   PubMed Web of Science ®Google Scholar
• Birk S, Edvinsson L, Olesen J, Kruuse C. Analysis of the effects of phosphodiesterase type 3 and 4 inhibitors in cerebral arteries. Eur J Pharmacol 2004;489(1):93–100. doi: 10.1016/j.ejphar.2004.02.038
   PubMed Web of Science ®Google Scholar
• Kennedy DO. Plants and the human brain. New York: Oxford University Press; 2014.
   Google Scholar
• Kennedy DO. Polyphenols and the human brain: plant “secondary metabolite” ecologic roles and endogenous signaling functions drive benefits. Advances in Nutrition 2014;5:515–33.
   Google Scholar
• Schellekens C, Perrinjaquet-Moccetti T, Wullschleger C, Heyne A. An extract from wild green oat improves rat behaviour. Phytother Res 2009;23(10):1371–1377. doi: 10.1002/ptr.2751
   PubMed Web of Science ®Google Scholar
• Dimpfel W, Storni C, Verbruggen M. Ingested oat herb extract (Avena sativa) changes EEG spectral frequencies in healthy subjects. J Altern Complement Med 2011;17(5):427–434. doi: 10.1089/acm.2010.0143
   PubMed Web of Science ®Google Scholar
• Berry NM, Robinson MJ, Bryan J, Buckley JD, Murphy KJ, Howe PR. Acute effects of an Avena sativa herb extract on responses to the stroop color–word test. J Altern Complement Med 2011;17(7):635–637. doi: 10.1089/acm.2010.0450
   PubMed Web of Science ®Google Scholar
• Wong RH, Howe PR, Coates AM, Buckley JD, Berry NM. Chronic consumption of a wild green oat extract (Neuravena) improves brachial flow-mediated dilatation and cerebrovascular responsiveness in older adults. J Hypertens 2013;31(1):192–200. doi: 10.1097/HJH.0b013e32835b04d4
   PubMed Web of Science ®Google Scholar
• Wong RH, Howe PR, Bryan J, Coates AM, Buckley JD, Berry NM. Chronic effects of a wild green oat extract supplementation on cognitive performance in older adults: a randomised, double-blind, placebo-controlled, crossover trial. Nutrients 2012;4(5):331–342. doi: 10.3390/nu4050331
   PubMed Web of Science ®Google Scholar
• Scholey AB, French SJ, Morris PJ, Kennedy DO, Milne AL, Haskell CF. Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort. J Clin Psychopharmacol 2010;24(10):1505–1514. doi: 10.1177/0269881109106923
   Web of Science ®Google Scholar
• Reay JL, Kennedy DO, Scholey AB. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Clin Psychopharmacol 2005;19(4):357–365. doi: 10.1177/0269881105053286
   Web of Science ®Google Scholar
• Kennedy DO, Dodd FL, Robertson BC, Okello EJ, Reay JL, Scholey AB, et al. Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults. J Clin Psychopharmacol 2011;25(8):1088–1100. doi: 10.1177/0269881110385594
   Web of Science ®Google Scholar
• Stonehouse W, Conlon CA, Podd J, Hill SR, Minihane AM, Haskell C, et al. DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trial. Am J Clin Nutr 2013;97(5):1134–1143. doi: 10.3945/ajcn.112.053371
   PubMed Web of Science ®Google Scholar
• Veasey RC, Gonzalez JT, Kennedy DO, Haskell CF, Stevenson EJ. Breakfast consumption and exercise interact to affect cognitive performance and mood later in the day. A Randomized Controlled Trial Appetite 2013;68(0):38–44.
   Google Scholar
• Bond A, Lader M. Use of analog scales in rating subjective feelings. Br J Med Psychol 1974;47(Sep):211–218. doi: 10.1111/j.2044-8341.1974.tb02285.x
   Web of Science ®Google Scholar
• Coltheart M. The MRC psycholinguistic database. The Quarterly Journal of Experimental Psychology 1981;33(4):497–505. doi: 10.1080/14640748108400805
   Web of Science ®Google Scholar
• Erdfelder E, Faul F, Buchner A. GPOWER: a general power analysis program. Behav Res Methods Instrum Comput 1996;28(1):1–11. doi: 10.3758/BF03203630
   Google Scholar
• Morgan AB, Lilienfeld SO. A meta-analytic review of the relation between antisocial behavior and neuropsychological measures of executive function. Clin Psychol Rev 2000;20(1):113–136. doi: 10.1016/S0272-7358(98)00096-8
   PubMed Web of Science ®Google Scholar
• Tildesley NTJ, Kennedy DO, Perry EK, Ballard CG, Savelev S, Wesnes KA, et al. Salvia lavandulaefolia (Spanish Sage) enhances memory in healthy young volunteers. Pharmacol Biochem Behav 2003;75(3):669–674. doi: 10.1016/S0091-3057(03)00122-9
   PubMed Web of Science ®Google Scholar
• Haskell CF, Kennedy DO, Wesnes KA, Milne AL, Scholey AB. A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guarana in humans. J Psychopharmacol 2007;21(1):65–70. doi: 10.1177/0269881106063815
   PubMed Web of Science ®Google Scholar
• Vina D, Serra S, Lamela M, Delogu G. Herbal natural products as a source of monoamine oxidase inhibitors: a review. Curr Top Med Chem 2012;12(20):2131–2144. doi: 10.2174/156802612805219996
   PubMed Web of Science ®Google Scholar
• Van Diermen D, Marston A, Bravo J, Reist M, Carrupt P-A, Hostettmann K. Monoamine oxidase inhibition by Rhodiola rosea L. Roots. J Ethnopharmacol 2009;122(2):397–401. doi: 10.1016/j.jep.2009.01.007
   PubMed Web of Science ®Google Scholar
• Singh R, Ramakrishna R, Bhateria M, Bhatta RS. In vitro evaluation of bacopa monniera extract and individual constituents on human recombinant monoamine oxidase enzymes. Phytother Res 2014;28(9):1419–1422. doi: 10.1002/ptr.5116
   PubMed Web of Science ®Google Scholar
• Watson AW, Haskell-Ramsay CF, Kennedy DO, Cooney JM, Trower T, Scheepens A. Acute supplementation with blackcurrant extracts modulates cognitive functioning and inhibits monoamine oxidase-B in healthy young adults. J Funct Foods 2015;17:524–539. doi: 10.1016/j.jff.2015.06.005
   Web of Science ®Google Scholar
• Heckman P, Blokland A, Ramaekers J, Prickaerts J. PDE and cognitive processing: beyond the memory domain. Neurobiol Learn Mem 2015;119:108–122. doi: 10.1016/j.nlm.2014.10.011
   PubMed Web of Science ®Google Scholar
• Richter W, Menniti FS, Zhang H-T, Conti M. PDE4 as a target for cognition enhancement. Expert Opin Ther Tar 2013;17(9):1011–1027. doi: 10.1517/14728222.2013.818656
   PubMed Web of Science ®Google Scholar
• Hooper L, Kay C, Abdelhamid A, Kroon PA, Cohn JS, Rimm EB, et al. Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials. Am J Clin Nutr 2012;95(3):740–751. doi: 10.3945/ajcn.111.023457
   PubMed Web of Science ®Google Scholar
• Kennedy DO, Wightman EL, Reay JL, Lietz G, Okello EJ, Wilde A, et al. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Am J Clin Nutr 2010;91(6):1590–1597. doi: 10.3945/ajcn.2009.28641
   PubMed Web of Science ®Google Scholar
• Wightman EL, Reay JL, Haskell CF, Williamson G, Dew TP, Kennedy DO. Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation. Br J Nutr 2014;112:203–213. doi: 10.1017/S0007114514000737
   PubMed Web of Science ®Google Scholar
• Sorond FA, Lipsitz LA, Hollenberg NK, Fisher ND. Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans. Neuropsychiatr Dis Treat 2008;4(2):433–440.
   PubMedGoogle Scholar
• Francis S, Head K, Morris P, Macdonald I. The effect of flavanol-rich cocoa on the fMRI response to a cognitive task in healthy young people. J Cardiovasc Pharmacol 2006;47:S215–S220. doi: 10.1097/00005344-200606001-00018
   PubMed Web of Science ®Google Scholar
• Scholey A, Downey LA, Ciorciari J, Pipingas A, Nolidin K, Finn M et al. Acute neurocognitive effects of epigallocatechin gallate (EGCG). Appetite 2012;58(2):767–770. doi: 10.1016/j.appet.2011.11.016
   PubMed Web of Science ®Google Scholar
• Field DT, Williams CM, Butler LT. Consumption of cocoa flavanols results in an acute improvement in visual and cognitive functions. Physiol Behav 2011;103(3–4):255–260. doi: 10.1016/j.physbeh.2011.02.013
   PubMed Web of Science ®Google Scholar
• Spencer JP. Flavonoids and brain health: multiple effects underpinned by common mechanisms. Genes Nutr 2009;4(4):243–250. doi: 10.1007/s12263-009-0136-3
   PubMed Web of Science ®Google Scholar
• Williams RJ, Spencer JPE. Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease. Free Radic Biol Med 2012;52(1):35–45. doi: 10.1016/j.freeradbiomed.2011.09.010
   PubMed Web of Science ®Google Scholar
• Baptista FI, Henriques AG, Silva AM, Wiltfang J, da Cruz e Silva OA. Flavonoids as therapeutic compounds targeting key proteins involved in Alzheimeŕ s disease. ACS Chem Neurosci 2014;5(2):83–92. doi: 10.1021/cn400213r
   PubMed Web of Science ®Google Scholar
• Francis G, Kerem Z, Makkar HPS, Becker K. The biological action of saponins in animal systems: a review. Br J Med Med Res 2002;88(6):587–605.
   Google Scholar
• Ibarrola D, Hellión-Ibarrola M, Montalbetti Y, Heinichen O, Campuzano M, Kennedy M et al. Antihypertensive effect of nuatigenin-3-O-β-chacotriose from Solanum sisymbriifolium Lam.(Solanaceae)(ñuatî pytâ) in experimentally hypertensive (ARH+ DOCA) rats under chronic administration. Phytomedicine 2011;18(8):634–640. doi: 10.1016/j.phymed.2011.01.012
   PubMed Web of Science ®Google Scholar
• Ibarrola DA, Hellion-Ibarrola MdC, Alvarenga NL, Ferro EA, Hatakeyama N, Shibuya N et al. Cardiovascular Action of Nuatigenosido from Solanum sisymbriifolium. Pharm Biol 2006;44(5):378–381. doi: 10.1080/13880200600748937
   Web of Science ®Google Scholar
• Kamper AM, Spilt A, de Craen AJM, van Buchem MA, Westendorp RGJ, Blauw GJ. Basal cerebral blood flow is dependent on the nitric oxide pathway in elderly but not in young healthy men. Exp Gerontol 2004;39(8):1245–1248. doi: 10.1016/j.exger.2004.04.001
   PubMed Web of Science ®Google Scholar
• Farkas E, de Wilde MC, Kiliaan AJ, Luiten PGM. Chronic cerebral hypoperfusion-related neuropathologic changes and compromised cognitive status: window of treatment. Drugs Today 2002;38(5):365–76. doi: 10.1358/dot.2002.38.5.677137
   PubMed Web of Science ®Google Scholar