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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 20, 2017 - Issue 6
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Original Articles

The effect of ketogenic diet in an animal model of autism induced by prenatal exposure to valproic acid

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References

  • Diagnostic and Statistical Manual of Mental Disorders (DSM-V). American Psychiatric Association; 2013.
  • Tuchman RF, Rapin I. Regression in pervasive developmental disorders: seizures and epileptiform electroencephalogram correlates. Pediatrics 1997;99:560–6. doi: 10.1542/peds.99.4.560
  • Gottfried C, Bambini-Junior V, Baronio D, Zanatta G, Silvestrin R B, Vaccaro T, et al. Valproic Acid in Autism Spectrum Disorder: From an Environmental Risk Factor to a Reliable Animal Model, 2013.
  • Ornoy A, Weinstein-Fudim L, Ergaz Z, Prenatal factors associated with autism spectrum disorder (ASD). Reprod Toxicol 2015;56:165–69.
  • Wood AG, Nadebaum C, Anderson V, Reutens D, Barton S, O'Brien TJ, et al. Prospective assessment of autism traits in children exposed to antiepileptic drugs during pregnancy. Epilepsia 2015;56:1047–55. doi: 10.1111/epi.13007
  • Bromley RL, Mawer GE, Briggs M, Cheyne C, Clayton-Smith J, García-Fiñana M, et al. The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs. J Neurol Neurosurg Psychiatry 2013;84:637–43. doi: 10.1136/jnnp-2012-304270
  • Currenti SA. Understanding and determining the etiology of autism. Cell Mol Neurobiol 2010;30:161–71. doi: 10.1007/s10571-009-9453-8
  • Christianson AL, Chesler N, Kromberg JG. Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs. Dev Med Child Neurol 1994;36:361–69. doi: 10.1111/j.1469-8749.1994.tb11858.x
  • Bambini-Junior V, Rodrigues L, Behr GA, Moreira JC, Riesgo R, Gottfried C, et al. Animal model of autism induced by prenatal exposure to valproate: behavioral changes and liver parameters. Brain Res 2011;1408:8–16. doi: 10.1016/j.brainres.2011.06.015
  • Crawley JN. Mouse behavioral assays relevant to the symptoms of autism. Brain Pathol 2007;17:448–59. doi: 10.1111/j.1750-3639.2007.00096.x
  • Meki AR, Hamed EA, Ezam KA. Effect of green tea extract and vitamin C on oxidant or antioxidant status of rheumatoid arthritis rat model. Indian J Clin Biochem 2009;24;280–7. doi: 10.1007/s12291-009-0053-7
  • Mehta MV, Gandal MJ, Siegel SJ. mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism. PLoS One 2011;6:e26077. doi: 10.1371/journal.pone.0026077
  • Sandhya T, Sowjanya J, Veeresh B. Bacopa monniera (L.) Wettst ameliorates behavioral alterations and oxidative markers in sodium valproate induced autism in rats. Neurochem Res 2012;37:1121–31. doi: 10.1007/s11064-012-0717-1
  • Kim P, Park JH, Kwon KJ, Kim KC, Kim HJ, Lee JM, et al. Effects of Korean red ginseng extracts on neural tube defects and impairment of social interaction induced by prenatal exposure to valproic acid. Food Chem Toxicol 2013;51:288–96. doi: 10.1016/j.fct.2012.10.011
  • Baronio D, Castro K, Gonchoroski T, de Melo GM, Nunes GD, Bambini-Junior V, et al. Effects of an H3R antagonist on the animal model of autism induced by prenatal exposure to valproic acid. PLoS One 2015;10:e0116363. doi: 10.1371/journal.pone.0116363
  • Freeman J, Veggiotti P, Lanzi G, Tagliabue A, Perucca E. The ketogenic diet: from molecular mechanisms to clinical effects. Epilepsy Res 2006;68:145–80. doi: 10.1016/j.eplepsyres.2005.10.003
  • Kossoff EH, Zupec-Kania BA, Rho JM. Ketogenic diets: an update for child neurologists. J Child Neurol 2009;24:979–88. doi: 10.1177/0883073809337162
  • Hartman AL, Gasior M, Vining EP, Rogawski MA. The neuropharmacology of the ketogenic diet. Pediatr Neurol 2007;36:281–92. doi: 10.1016/j.pediatrneurol.2007.02.008
  • Kossoff EH. The ketogenic diet: it's about ‘time’. Dev Med Child Neurol 2009;51:252–3. doi: 10.1111/j.1469-8749.2009.03280.x
  • Nordli D. The ketogenic diet: uses and abuses. Neurology 2002;58:S21–24. doi: 10.1212/WNL.58.12_suppl_7.S21
  • Wilder R, Mayo Clin Bull 1921; p. 307.
  • Herbert MR, Buckley JA. Autism and dietary therapy: case report and review of the literature. J Child Neurol 2013;28:975–82. doi: 10.1177/0883073813488668
  • Evangeliou A, Vlachonikolis I, Mihailidou H, Spilioti M, Skarpalezou A, Makaronas N, et al. Application of a ketogenic diet in children with autistic behavior: pilot study. J Child Neurol 2003;18: 113–8. doi: 10.1177/08830738030180020501
  • Dupuis N, Curatolo N, Benoist JF, Auvin S. Ketogenic diet exhibits anti-inflammatory properties. Epilepsia 2015;56:e95–98. doi: 10.1111/epi.13038
  • Masino SA, Ruskin DN. Ketogenic diets and pain. J Child Neurol 2013;28:993–1001. doi: 10.1177/0883073813487595
  • Kern JK, Trivedi MH, Garver CR, Grannemann BD, Andrews AA, Savla JS, et al. The pattern of sensory processing abnormalities in autism. Autism 2006;10:480–94. doi: 10.1177/1362361306066564
  • Klintwall L, Holm A, Eriksson M, Carlsson LH, Olsson MB, Hedvall A, et al. Sensory abnormalities in autism. A brief report. Res Dev Disabil 2011;32:795–800. doi: 10.1016/j.ridd.2010.10.021
  • Moore DJ. Acute pain experience in individuals with autism spectrum disorders: a review. Autism 2015;19:387–99. doi: 10.1177/1362361314527839
  • Ruskin DN, Svedova J, Cote JL, Sandau U, Rho JM, Kawamura M Jr, et al. Ketogenic diet improves core symptoms of autism in BTBR mice. PLoS One 2013;8:e65021. doi: 10.1371/journal.pone.0065021
  • Ahn Y, Narous M, Tobias R, Rho JM, Mychasiuk R. The ketogenic diet modifies social and metabolic alterations identified in the prenatal valproic acid model of autism spectrum disorder. Dev Neurosci 2014;36:371–80. doi: 10.1159/000362645
  • Ziegler DR, Gamaro GD, Araújo E, Bassani MG, Perry ML, Dalmaz C, et al. Nociception and locomotor activity are increased in ketogenic diet fed rats. Physiol Behav 2005;84:421–7. doi: 10.1016/j.physbeh.2005.01.003
  • Szot P, Weinshenker D, Rho JM, Storey TW, Schwartzkroin PA. Norepinephrine is required for the anticonvulsant effect of the ketogenic diet. Brain Res Dev Brain Res 2001;129:211–4. doi: 10.1016/S0165-3806(01)00213-9
  • Sullivan PG, Rippy NA, Dorenbos K, Concepcion RC, et al. The ketogenic diet increases mitochondrial uncoupling protein levels and activity. Ann Neurol 2004;55:576–80. doi: 10.1002/ana.20062
  • Stafstrom CE, Rho JM. The ketogenic diet as a treatment paradigm for diverse neurological disorders. Front Pharmacol 2012;3:59. doi: 10.3389/fphar.2012.00059
  • Paylor R, Spencer CM, Yuva-Paylor LA, Pieke-Dahl S. The use of behavioral test batteries, II: effect of test interval. Physiol Behav 2006;87:95–102. doi: 10.1016/j.physbeh.2005.09.002
  • Malkova NV, Yu CZ, Hsiao EY, Moore MJ, Patterson PH. Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism. Brain Behav Immun 2012;26:607–16. doi: 10.1016/j.bbi.2012.01.011
  • Thomas A, Burant A, Bui N, Graham D, Yuva-Paylor LA, Paylor R, Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety. Psychopharmacology (Berl) 2009;204:361–73. doi: 10.1007/s00213-009-1466-y
  • Silverman JL, Tolu SS, Barkan CL, Crawley JN. Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP. Neuropsychopharmacology 2010;35:976–89. doi: 10.1038/npp.2009.201
  • Ruskin DN, Masino SA. The nervous system and metabolic dysregulation: emerging evidence converges on ketogenic diet therapy. Front Neurosci 2012;6:33. doi: 10.3389/fnins.2012.00033
  • Masino SA, Kawamura M, Wasser CD, Wasser CA, Ruskin DN. Adenosine, ketogenic diet and epilepsy: the emerging therapeutic relationship between metabolism and brain activity. Curr Neuropharmacol 2009;7;257–68. doi: 10.2174/157015909789152164
  • Bodnar RJ, Kelly DD, Glusman M. 2-Deoxy-d-glucose analgesia: influences of opiate and non-opiate factors. Pharmacol Biochem Behav 1979;11:297–301. doi: 10.1016/0091-3057(79)90138-2
  • Schneider T, Przewłocki R. Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism. Neuropsychopharmacology 2005;30:80–9. doi: 10.1038/sj.npp.1300518
  • Allely CS. Pain sensitivity and observer perception of pain in individuals with autistic spectrum disorder. Sci World J 2013;2013:916178. doi: 10.1155/2013/916178
  • Kashiwaya Y, Bergman C, Lee JH, Wan R, King MT, Mughal MR. A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiol Aging 2013;34:1530–9. doi: 10.1016/j.neurobiolaging.2012.11.023
  • Mantis JG, Fritz CL, Marsh J, Heinrichs SC, Seyfried TN. Improvement in motor and exploratory behavior in Rett syndrome mice with restricted ketogenic and standard diets. Epilepsy Behav 2009;15:133–41. doi: 10.1016/j.yebeh.2009.02.038
  • Esbensen AJ, Seltzer MM, Lam KS, Bodfish JW. Age-related differences in restricted repetitive behaviors in autism spectrum disorders. J Autism Dev Disord 2009;39:57–66. doi: 10.1007/s10803-008-0599-x

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