Cognition enhancing effect of the aqueous extract of Cinnamomum zeylanicum on non-transgenic Alzheimer's disease rat model: Biochemical, histological, and behavioural studies

References

• Cohen RM, Rezai-Zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, et al. A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss. J Neurosci 2013;33:6245–56. doi: 10.1523/JNEUROSCI.3672-12.2013
   PubMed Web of Science ®Google Scholar
• Gomez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, et al. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol 1997;41:17–24. doi: 10.1002/ana.410410106
   PubMed Web of Science ®Google Scholar
• Krasuski JS, Alexander GE, Horwitz B, Daly EM, Murphy DG, Rapoport SI, et al. Volumes of medial temporal lobe structures in patients with Alzheimer's disease and mild cognitive impairment (and in healthy controls). Biol Psychiatry 1998;43:60–68. doi: 10.1016/S0006-3223(97)00013-9
   PubMed Web of Science ®Google Scholar
• Killiany RJ, Hyman BT, Gomez-Isla T, Moss MB, Kikinis R, Jolesz F, et al. MRI measures of entorhinal cortex vs hippocampus in preclinical AD. Neurology 2002;58:1188–96. doi: 10.1212/WNL.58.8.1188
   PubMed Web of Science ®Google Scholar
• Gupta A, Bisht B, Dey CS. Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes. Neuropharmacology 2011;60:910–20. doi: 10.1016/j.neuropharm.2011.01.033
   PubMed Web of Science ®Google Scholar
• de la Monte SM, Wands JR. Alzheimer's disease is type 3 diabetes-evidence reviewed. J Diabetes Sci Technol 2008;2:1101–13. doi: 10.1177/193229680800200619
   PubMedGoogle Scholar
• Angelini , Rafacho A, Boschero AC, Bosqueiro JR. Involvement of the cholinergic pathway in glucocorticoid-induced hyperinsulinemia in rats. Diabetes Res Clin Pract 2010;87:184–91. doi: 10.1016/j.diabres.2009.11.008
   PubMed Web of Science ®Google Scholar
• Mathew M, Subramanian S. In vitro screening for anti-cholinesterase and antioxidant activity of methanolic extracts of Ayurvedic medicinal plants used for cognitive disorders. PLoS ONE 2014;9:e86804. doi: 10.1371/journal.pone.0086804
   PubMed Web of Science ®Google Scholar
• Madhavadas S, Subramanian S. Combination of Spirulina with glycyrrhizin prevents cognitive dysfunction in aged obese rats. Indian J Pharmacol 2015;47:39–44. doi: 10.4103/0253-7613.150327
   PubMed Web of Science ®Google Scholar
• Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215–8. doi: 10.2337/diacare.26.12.3215
   PubMed Web of Science ®Google Scholar
• Lu Z, Jia Q, Wang R, Wu X, Wu Y, Huang C, et al. Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different cinnamon barks. Phytomedicine 2011;18:298–302. doi: 10.1016/j.phymed.2010.08.008
   PubMed Web of Science ®Google Scholar
• Qin B, Panickar KS, Anderson RA. Cinnamon: potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes. J Diabetes Sci Technol 2010;4:685–93. doi: 10.1177/193229681000400324
   PubMedGoogle Scholar
• Couturier K, Batandier C, Awada M, Hininger-Favier I, Canini F, Anderson RA, et al. Cinnamon improves insulin sensitivity and alters the body composition in an animal model of the metabolic syndrome. Arch Biochem Biophys 2010;501:158–61. doi: 10.1016/j.abb.2010.05.032
   PubMed Web of Science ®Google Scholar
• Jain S, Sangma T, Shukla SK, Mediratta PK. Effect of Cinnamomum zeylanicum extract on scopolamine-induced cognitive impairment and oxidative stress in rats. Nutr Neurosci 2015;18:210–6. doi: 10.1179/1476830514Y.0000000113
   PubMed Web of Science ®Google Scholar
• Peterson DW, George RC, Scaramozzino F, Lapointe NE, Anderson RA, Graves DJ, et al. Cinnamon extract inhibits Tau aggregation associated with Alzheimer's disease in vitro. J Alzheimers Dis 2009;17:585–7. doi: 10.3233/JAD-2009-1083
   PubMed Web of Science ®Google Scholar
• Frydman-Marom A, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S, et al. Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models. PLoS ONE 2011;6:e16564. doi: 10.1371/journal.pone.0016564
   PubMed Web of Science ®Google Scholar
• Jiao L, Zhang X, Huang L, Gong H, Cheng B, Sun Y, et al. Proanthocyanidins are the major anti-diabetic components of cinnamon water extract. Food Chem Toxicol 2013;56:398–405. doi: 10.1016/j.fct.2013.02.049
   PubMed Web of Science ®Google Scholar
• Madhavadas S, Kutty BM, Subramanian S. Amyloid beta lowering and cognition enhancing effects of ghrelin receptor analog [D-Lys (3)] GHRP-6 in rat model of obesity. Indian J Biochem Biophys 2014;51:257–62.
   PubMed Web of Science ®Google Scholar
• Mathew M, Subramanian S. In vitro evaluation of anti-Alzheimer effects of dry ginger (Zingiber officinale Roscoe) extract. Indian J Exp Biol 2014;52:606–12.
   PubMed Web of Science ®Google Scholar
• Ellman GL, Courtney KD, Andres V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961;7:88–95. doi: 10.1016/0006-2952(61)90145-9
   PubMed Web of Science ®Google Scholar
• Paxinos G, Watson C. The rat nervous coordinates, the new coronal set. New York: Elsevier; 2004.
   Google Scholar
• Madhavadas S, Kapgal VK, Kutty BM, Subramanian S. The neuroprotective effect of dark chocolate in monosodium glutamate-induced nontransgenic Alzheimer disease model rats: biochemical, behavioral, and histological studies. J Dietary Suppl 2016;13:449–60. doi: 10.3109/19390211.2015.1108946
   PubMedGoogle Scholar
• Kjonigsen LJ, Leergaard TB, Witter MP, Bjaalie JG. Digital atlas of anatomical subdivisions and boundaries of the rat hippocampal region. Front Neuroinform 2011;5:2. doi: 10.3389/fninf.2011.00002
   PubMedGoogle Scholar
• Gundersen HJ, Jensen EB, Kieu K, Nielsen J. The efficiency of systematic sampling in stereology – reconsidered. J Microsc 1999;193:199–211. doi: 10.1046/j.1365-2818.1999.00457.x
   PubMed Web of Science ®Google Scholar
• Hynd MR, Scott HL, Dodd PR. Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease. Neurochem Int 2004;45:583–95. doi: 10.1016/j.neuint.2004.03.007
   PubMed Web of Science ®Google Scholar
• Grewer C, Gameiro A, Zhang Z, Tao Z, Braams S, Rauen T. Glutamate forward and reverse transport: from molecular mechanism to transporter-mediated release after ischemia. IUBMB Life 2008;60:609–19. doi: 10.1002/iub.98
   PubMed Web of Science ®Google Scholar
• Amin KA, Kamel HH, Abdeltawab MA. Protective effect of Garcinia against renal oxidative stress and biomarkers induced by high fat and sucrose diet. Lipids Health Dis 2011;10:6. doi: 10.1186/1476-511X-10-6
   PubMed Web of Science ®Google Scholar
• Geula C, Darvesh S. Butyrylcholinesterase, cholinergic neurotransmission and the pathology of Alzheimer's disease. Drugs Today 2004;40:711–21. doi: 10.1358/dot.2004.40.8.850473
   PubMed Web of Science ®Google Scholar
• Luchsinger JA, Gustafson DR. Adiposity and Alzheimer's disease. Curr Opin Clin Nutr Metab Care 2009;12:15–21. doi: 10.1097/MCO.0b013e32831c8c71
   PubMed Web of Science ®Google Scholar
• Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, et al. Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J Agric Food Chem 2004;52:65–70. doi: 10.1021/jf034916b
   PubMed Web of Science ®Google Scholar
• Anderson RA, Qin B, Canini F, Poulet L, Roussel AM. Cinnamon counteracts the negative effects of a high fat/high fructose diet on behaviour, brain insulin signalling and Alzheimer-associated changes. PLoS ONE 2013;8:e83243. doi: 10.1371/journal.pone.0083243
   PubMed Web of Science ®Google Scholar
• Plotkin DA, Jarvik LF. Cholinergic dysfunction in Alzheimer disease: cause or effect? Prog Brain Res 1986;65:91–103. doi: 10.1016/S0079-6123(08)60644-5
   PubMed Web of Science ®Google Scholar
• Whitehouse PJ, Price DL, Clark AW, Coyle JT, DeLong MR. Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol 1981;10:122–6. doi: 10.1002/ana.410100203
   PubMed Web of Science ®Google Scholar
• Samadi A, Valderas C, De los Rios C, Bastida A, Chioua M, Gonzalez-Lafuente L, et al. Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles. Bioorg Med Chem 2011;19:122–33. doi: 10.1016/j.bmc.2010.11.040
   PubMed Web of Science ®Google Scholar
• Yates CM, Simpson J, Gordon A, Maloney AF, Allison Y, Ritchie IM, et al. Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and Down's syndrome. Brain Res 1983;280:119–26. doi: 10.1016/0006-8993(83)91179-4
   PubMed Web of Science ®Google Scholar
• Hoshi M, Takashima A, Noguchi K, Murayama M, Sato M, Kondo S, et al. Regulation of mitochondrial pyruvate dehydrogenase activity by Tau protein kinase I/glycogen synthase kinase 3beta in brain. Proc Natl Acad Sci USA 1996;93:2719–23. doi: 10.1073/pnas.93.7.2719
   PubMed Web of Science ®Google Scholar
• Wang H, Wang R, Zhao Z, Ji Z, Xu S, Holscher C, et al. Coexistences of insulin signalling-related proteins and choline acetyltransferase in neurons. Brain Res 2009;1249:237–43. doi: 10.1016/j.brainres.2008.10.046
   PubMed Web of Science ®Google Scholar
• Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr 2001;20:327–6. doi: 10.1080/07315724.2001.10719053
   PubMed Web of Science ®Google Scholar
• Gomez-Isla T, Price JL, McKeel Jr DW, Morris JC, Growdon JH, Hyman BT. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J Neurosci 1996;16:4491–500.
   PubMed Web of Science ®Google Scholar
• Forster MJ, Dubey A, Dawson KM, Stutts WA, Lal H, Sohal RS. Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain. Proc Natl Acad Sci 1996;93:4765–9. doi: 10.1073/pnas.93.10.4765
   PubMed Web of Science ®Google Scholar
• Squire LR. Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. Psychol Rev 2002;99:195–231. doi: 10.1037/0033-295X.99.2.195
   Web of Science ®Google Scholar
• Schuff N, Matsumoto S, Kmiecik J, Studholme C, Du A, Ezekiel F, et al. Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging. Alzheimers Dement 2009;5:454–62. doi: 10.1016/j.jalz.2009.04.1233
   PubMed Web of Science ®Google Scholar
• West MJ, Kawas CH, Stewart WF, Rudow GL, Troncoso JC. Hippocampal neurons in pre-clinical Alzheimer's disease. Neurobiol Aging 2004;25:1205–12. doi: 10.1016/j.neurobiolaging.2003.12.005
   PubMed Web of Science ®Google Scholar
• McEwen BS, Sapolsky RM. Stress and cognitive function. Curr Opin Neurobiol 1995;5:205–16. doi: 10.1016/0959-4388(95)80028-X
   PubMed Web of Science ®Google Scholar
• Guzmán-Vélez E, Feinstein JS, Tranel D. Feelings without memory in Alzheimer disease. Cogn Behav Neurol 2014;27:117–29. doi: 10.1097/WNN.0000000000000020
   PubMed Web of Science ®Google Scholar
• Hasselmo ME, McClelland JL. Neural models of memory. Curr Opin Neurobiol 1999;9:184–8. doi: 10.1016/S0959-4388(99)80025-7
   PubMed Web of Science ®Google Scholar
• Den Heijer T, Van Der Lijn F, Koudstaal PJ, Hofman A, Van Der Lugt A, Krestin GP, et al. A 10-year follow-up of hippocampal volume on magnetic resonance imaging in early dementia and cognitive decline. Brain 2010;133:1163–72. doi: 10.1093/brain/awq048
   PubMed Web of Science ®Google Scholar
• Debette S, Seshadri S, Beiser A, Au R, Himali JJ, Palumbo C, et al. Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline. Neurology 2011;77:461–8. doi: 10.1212/WNL.0b013e318227b227
   PubMed Web of Science ®Google Scholar
• Zhu Y, Fotinos A, Mao LLJ, Atassi N, Zhou EW, Ahmad S, et al. Neuroprotective agents target molecular mechanisms of disease in ALS. Drug Discov Today 2015;20:65–75. doi: 10.1016/j.drudis.2014.08.016
   PubMed Web of Science ®Google Scholar
• Smith AM, Pappalardo D, Chen W-JA. Estimation of neuronal numbers in rat hippocampus following neonatal amphetamine exposure: a stereology study. Neurotoxicol Teratol 2008;30:495–502. doi: 10.1016/j.ntt.2008.05.001
   PubMed Web of Science ®Google Scholar
• Fitting S, Booze RM, Hasselrot U, Mactutus CF. Dose-dependent long-term effects of Tat in the rat hippocampal formation: a design based stereological study. Hippocampus 2010;20:469–80.
   PubMed Web of Science ®Google Scholar
• Dokter M, von Bohlen und Halbach O. Neurogenesis within the adult hippocampus under physiological conditions and in depression. Neural Regen Res 2012;7:552–9.
   PubMed Web of Science ®Google Scholar
• Amrein I, Isler K, Lipp HP. Comparing adult hippocampal neurogenesis in mammalian species and orders: influence of chronological age and life history stage. Eur J Neurosci 2012;34:978–87. doi: 10.1111/j.1460-9568.2011.07804.x
   Web of Science ®Google Scholar
• von Bohlen und Halbach O. Involvement of BDNF in age-dependent alterations in the hippocampus. Front Aging Neurosci 2010;2:1–11.
   PubMed Web of Science ®Google Scholar
• Jana A, Modi KK, Roy A, Anderson JA, van Breemen RB, Pahan K. Up-regulation of neurotrophic factors by cinnamon and its metabolite sodium benzoate: therapeutic implications for neurodegenerative disorders. J Neuroimmune Pharmacol 2013;8:739–55. doi: 10.1007/s11481-013-9447-7
   PubMed Web of Science ®Google Scholar