Publication Cover
Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 21, 2018 - Issue 9
265
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

Increased total DNA damage and oxidative stress in brain are associated with decreased longevity in high sucrose diet fed WNIN/Gr-Ob obese rats

, , &

References

  • Ahima RS. Connecting obesity, aging and diabetes. Nat Med 2009;15:996–7. doi: 10.1038/nm0909-996
  • Fontana L, Klein S. Aging, adiposity, and calorie restriction. JAMA 2007;297:986–94. doi: 10.1001/jama.297.9.986
  • Freitas AA, de Magalhães JP. A review and appraisal of the DNA damage theory of ageing. Mutat Res 2011;728:12–22. doi: 10.1016/j.mrrev.2011.05.001
  • Gensler HL, Bernstein H. DNA damage as the primary cause of aging. Q Rev Biol 1981;56:279–303. doi: 10.1086/412317
  • Rao AV, Balachandran B. Role of oxidative stress and antioxidants in neurodegenerative diseases. Nutr Neurosci 2002;5:291–309. doi: 10.1080/1028415021000033767
  • Nouspikel T, Hanawalt PC. DNA repair in terminally differentiated cells. DNA Repair (Amst) 2002;22:59–75. doi: 10.1016/S1568-7864(01)00005-2
  • Sohal RS, Agarwal S, Candas M, Forster MJ, Lal H. Effect of age and caloric restriction on DNA oxidative damage in different tissues of C56BL/6 mice. Mech Age Dev 1994;76:215–24. doi: 10.1016/0047-6374(94)91595-4
  • Hamilton ML, Van Remmen H, Drake JA, Yang H, Guo ZM, Kewitt K, et al. Does oxidative damage to DNA increase with age? Proc Natl Acad Sci U S A 2001;98:10469–74. doi: 10.1073/pnas.171202698
  • Dorszewska J, Adamczewska-Goncerzewicz Z. Oxidative damage to DNA, p53 gene expression and p53 protein level in the process of aging in rat brain. Respir Physiol Neurobiol 2004;139:227–36. doi: 10.1016/j.resp.2003.10.005
  • Gedik CM, Grant G, Morrice PC, Wood SG, Collins AR. Effects of age and dietary restriction on oxidative DNA damage, antioxidant protection and DNA repair in rats. Eur J Nutr 2004;44:263–72. doi: 10.1007/s00394-004-0520-0
  • Borgesius NZ, de Waard MC, van der Pluijm I, Omrani A, Zondag GC, van der Horst GT, et al. Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair. J Neurosci 2011;31:12543–53. doi: 10.1523/JNEUROSCI.1589-11.2011
  • Mariani E, Polidori MC, Cherubini A, Mecocci P. Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. J Chromatogr B Analyt Technol Biomed Life Sci 2005;827:65–75. doi: 10.1016/j.jchromb.2005.04.023
  • Gandhi S, Abramov AY. Mechanism of oxidative stress in neurodegeneration. Oxid Med Cell Longev2012;2012:428010. doi: 10.1155/2012/428010
  • Woodbine L, Brunton H, Goodarzi AA, Shibata A, Jeggo PA. Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair. Nucleic Acids Res 2011;39:6986–97. doi: 10.1093/nar/gkr331
  • Duca FA, Swartz TD, Covasa M. Effect of diet on preference and intake of sucrose in obese prone and resistant rats. PLoS One 2014;9:e111232. doi: 10.1371/journal.pone.0111232
  • Boden G, Homko C, Barrero CA, Stein TP, Chen X, Cheung P, et al. Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men. Sci Transl Med 2015;7(304):304–7. doi: 10.1126/scitranslmed.aac4765
  • Ronan L, Alexander-Bloch AF, Wagstyl K, Farooqi S, Brayne C, Tyler LK. Cam-CAN, Fletcher PC. Obesity associated with increased brain age from midlife. Neurobiol Aging 2016;47:63–70. doi: 10.1016/j.neurobiolaging.2016.07.010
  • Mehla J, Chauhan BC, Chauhan NB. Experimental induction of type 2 diabetes in aging-accelerated mice triggered Alzheimer-like pathology and memory deficits. J Alzheimers Dis 2014;39:145–62.
  • Roriz-Filho JS, Sá-Roriz TM, Rosset I, Camozzato AL, Santos AC, Chaves ML, et al. (Pre)diabetes, brain aging, and cognition. Biochim Biophys Acta 2009;1792:432–43. doi: 10.1016/j.bbadis.2008.12.003
  • Djuric Z, Lu MH, Lewis SM, Luongo DA, Chen XW, Heilbrun LK, et al. Oxidative DNA damage levels in rats fed low-fat, high-fat, or calorie-restricted diets. Toxicol Appl Pharmacol 1992;115:156–60. doi: 10.1016/0041-008X(92)90318-M
  • Hoeijmakers JH. DNA damage, aging, and cancer. N Engl J Med 2009;361:1475–85. doi: 10.1056/NEJMra0804615
  • Giridharan NV, Lakshmi CN, Raghuramulu N. Identification of impaired glucose tolerant animals from a Wistar inbred rat colony. Libratory Anim Sci 1997;47:428–31.
  • Harishankar N, Vajreswari A, Giridharan NV. WNIN/GR-Ob – An insulin-resistant obese rat model from inbred WNIN strain for studies on obesity associated with diabetes. Indian J Med Res 2011;134:320–9.
  • Singh H, Ganneru S, Malakapalli V, Chalasani M, Nappanveettil G, Bhonde RR, et al. Islet adaptation to obesity and insulin resistance in WNIN/GR-Ob rats. Islets 2014;6:5–6. doi: 10.1080/19382014.2014.998099
  • Yang JS, Nam HJ, Seo M, Han SK, Choi Y, Nam HG, et al. OASIS: online application for the survival analysis of lifespan assays performed in aging research. PLoS One 2011;6:e23525. doi: 10.1371/journal.pone.0023525
  • Goel MK, Khanna P, Kishore J. Understanding survival analysis: Kaplan–Meier estimate. Int J Ayurveda Res 2010;1:274–8. doi: 10.4103/0974-7788.76794
  • Swain U, Sindhu KK, Boda U, Pothani S, Giridharan NV, Raghunath M, et al. Studies on the molecular correlates of genomic stability in rat brain cells following Amalakirasayana therapy. Mech Ageing Dev 2012;133:112–7. doi: 10.1016/j.mad.2011.10.006
  • Sinha JK, Ghosh S, Swain U, Giridharan NV, Raghunath M. Increased acromolecular damage due to oxidative stress in the neocortex and hippocampus of WNIN/Ob, a novel rat model of premature aging. Neuroscience 2014;269:256–64. doi: 10.1016/j.neuroscience.2014.03.040
  • Gupta A, Bhatt ML, Misra MK. Lipid peroxidation and antioxidant status in head and neck squamous cell carcinoma patients. Oxid Med Cell Longev 2009;2:68–72. doi: 10.4161/oxim.2.2.8160
  • Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974;47:469–74. doi: 10.1111/j.1432-1033.1974.tb03714.x
  • Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959;82:70–7. doi: 10.1016/0003-9861(59)90090-6
  • Merksamer PI, Liu Y, He W, Hirschey MD, Chen D, Verdin E. The sirtuins, oxidative stress and aging: an emerging link. Aging (Albany NY) 2013;5:144–50. doi: 10.18632/aging.100544
  • Cui H, Kong Y, Zhang H. Oxidative stress, mitochondrial dysfunction, and aging. J Signal Transduct 2012;2012:646354. doi: 10.1155/2012/646354
  • Klaunig JE, Kamendulis LM, Hocevar BA. Oxidative stress and oxidative damage in carcinogenesis. Toxicol Pathol 2010;38:96–109. doi: 10.1177/0192623309356453
  • Chen JH, Hales CN, Ozanne SE. DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res 2007;35:7417–28. doi: 10.1093/nar/gkm681
  • Swain U, Rao KS. Age-dependent decline of DNA base excision repair activity in rat cortical neurons. Mech Ageing Dev 2012;133:186–94. doi: 10.1016/j.mad.2012.01.001
  • Villareal DT, Apovian CM, Kushner RF, Klein S. American Society for Nutrition; NAASO, The Obesity Society. Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Obes Res 2005;13:1849–63. doi: 10.1038/oby.2005.228
  • Petersen KS, Smith C. Ageing-associated oxidative stress and inflammation are alleviated by products from grapes. Oxid Med Cell Longev 2016;2016:6236309. doi: 10.1155/2016/6236309
  • Potukuchi A, Addepally U, Manchala R. Increased macromolecular damage underlies the decreased longevity of Wnin/Gr-Ob rats fed high sucrose diet. J Nutr Health Food Eng 2017;6:00184.
  • Aruna P, Uma A, Chiranjeevi P, Malathi U, Surekha M, Suresh P, et al. High sucrose diet induced diabetes in WNIN/Gr-Ob obese rats and the underlying / associated biochemical and histological changes, Accepted manuscript IJEB, Manuscript No.: IJEB/MS/LoA/2017/EB160307-1.
  • Richardson AG, Schadt EE. The role of macromolecular damage in aging and age-related disease. J Gerontol A Biol Sci Med Sci 2014;1:S28–32. doi: 10.1093/gerona/glu056
  • Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol 2011;192:547–56. doi: 10.1083/jcb.201009094
  • Cotman CW, Su JH. Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol 1996;6:493–506. doi: 10.1111/j.1750-3639.1996.tb00878.x
  • Treviño S, Aguilar-Alonso P, Flores Hernandez JA, Brambila E, Guevara J, Flores G, et al. A high calorie diet causes memory loss, metabolic syndrome and oxidative stress into hippocampus and temporal cortex of rats. Synapse 2015;69:421–33. doi: 10.1002/syn.21832

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.