Publication Cover
Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 22, 2019 - Issue 2
225
Views
9
CrossRef citations to date
0
Altmetric
Articles

Omega-3 fatty acid attenuates oxidative stress in cerebral cortex, cerebellum, and hippocampus tissue and improves neurobehavioral activity in chronic lead-induced neurotoxicity

, , ORCID Icon, ORCID Icon, , & show all

References

  • Kalia K, Flora SJ. Strategies for safe and effective therapeutic measures for chronic arsenic and lead poisoning. J Occup Health 2005;47:1–21. doi: 10.1539/joh.47.1
  • Ghareeb DA, Hussien HM, Khalil AA, El-Saadani MA, Ali AN. Toxic effects of lead exposure on the brain of rats: involvement of oxidative stress, inflammation, acetylcholinesterase and the beneficial role of flaxseed extract. Toxicol Environ Chem 2009;92(1):187–95. doi: 10.1080/02772240902830631
  • White LD, Cory-Slechta DA, Gilbert ME, Tiffany-Castiglioni E, Zawia NH, Virgolini M, et al. New and evolving concepts in the neurotoxicology of lead. Toxicol Appl Pharmacol 2007;225(1):1–27. doi: 10.1016/j.taap.2007.08.001
  • Spivey A. The weight of lead: effects add up in adults. Environ Health Perspect 2007;15(1): A30–6.
  • Murata K, Iwata T, Dakeishi M, Karita K. Lead toxicity: does the critical level of lead resulting in adverse effects differ between adults and children. J Occup Health 2009;1(1):1–12. doi: 10.1539/joh.K8003
  • Lidsky TI, Schneider JS. Adverse effects of childhood lead poisoning: the clinical neuropsychological perspective. Environ Res 2006;100:284–93. doi: 10.1016/j.envres.2005.03.002
  • Menke A, Muntner P, Batuman P, Silbergeld EK, Guallar E. Blood lead below 0.48 μmol/L (100 μgL-1) and mortality among US adults. Circulation 2006;114:1388–94. doi: 10.1161/CIRCULATIONAHA.106.628321
  • Shukla PK, Khanna VK, Khan MY, Srimal RC. Protective effect of curcumin against lead neurotoxicity in rat. Hum Exp Toxicol 2003;12:653–8. doi: 10.1191/0960327103ht411oa
  • Hossain S, Bhowmick S, Jahan S, Rozario L, Sarkar M, Islam S, et al. Maternal lead exposure decreases the levels of brain development and cognition-related proteins with concomitant upsurges of oxidative stress, inflammatory response and apoptosis in the offspring rats. Neurotoxicol 2016;56:150–8. doi: 10.1016/j.neuro.2016.07.013
  • Cleveland LM, Minter ML, Cobb KA, Scott AA, German VF. Lead hazards for pregnant women and children: part 1: immigrants and the poor shoulder most of the burden of lead exposure in this country. Part 1 of a two-part article details how exposure happens, whom it affects, and the harm it can do. Am J Nurs 2008;108:40–9.
  • Goyer RA. Results of lead research: prenatal exposure and neurological consequences. Environ Health Perspect 1996;104:1050–4. doi: 10.1289/ehp.961041050
  • Kasperczyk S, Birkner E, Kasperczyk A, Kasperczyk J. Lipids, lipid peroxidation and 7-ketocholesterol in workers exposed to lead. Hum Exp Toxicol 2005;24:287–95. doi: 10.1191/0960327105ht528oa
  • Flora SJS. Nutritional components modify metal absorption, toxic response and chelation therapy. J Nut Environ Med 2002;12:53–6. doi: 10.1080/13590840220123361
  • Sanders T, Liu Y, Buchner V, Tchounwou PB. Neurotoxic effects and biomarkers of lead exposure: a review. Res Environ Health 2009;24:15–45.
  • Singh PK, Nath R, Ahmad MK, Rawat A, Babu S, Dixit RK. Attenuation of lead neurotoxicity by supplementation of polyunsaturated fatty acid in Wistar rats. Nutr Neurosci 2016;19(9):396–405. doi: 10.1179/1476830515Y.0000000028
  • Singh PK, Rawat A, Dixit RK, Kumar P, Nath R. Behavioral and neurochemical effects of omega-3 fatty acids against lead aetate exposure in male wistar rats: an experimental study. Int J Curr Res 2015;7(9):20936–44.
  • Denis I, Potier B, Heberden C, Vancassel S. Omega-3 polyunsaturated fatty acid and brainaging. Curr Opin Clin Nutr Metab Care 2015;18:139–46. doi: 10.1097/MCO.0000000000000141
  • Parlettaa N, Milteb CM, Meyerc BJ. Nutritional modulation of cognitive function and mental health. J Nutr Biochem 2013;24:725–43. doi: 10.1016/j.jnutbio.2013.01.002
  • Wainwright PE. Dietary essential fatty acids and brain function: a developmental perspective on mechanisms. Proc Nutr Soc 2002;61:61–9. doi: 10.1079/PNS2001130
  • Feng Z, Zou X, Jia H, Li X, Zhu Z, Liu X, et al. Maternal docosahexaenoic acid feeding protects against impairment of learning and memory and oxidative stress in parentally stressed rats: possible role of neuronal mitochondria metabolism. Antioxid Redox Signal 2012;16:275–89. doi: 10.1089/ars.2010.3750
  • Tuzun F, Kumral A, Ozbal S, Dilek M, Tugyan K, Duman N, et al. Maternal prenatal omega-3 fatty acid supplementation attenuates hyperoxia-induced apoptosis in the developing rat brain. Int J Dev Neurosci 2012;30:315–23. doi: 10.1016/j.ijdevneu.2012.01.007
  • Wu A, Ying Z, Gomez-Pinilla F. Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. Neurosci 2008;155:751–9. doi: 10.1016/j.neuroscience.2008.05.061
  • Cao D, Kevala K, Kim J, Moon HS, Jun SB, Lovinger D, et al. Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. J Neurochem 2009;111:510–21. doi: 10.1111/j.1471-4159.2009.06335.x
  • Rathod R, Kale A, Joshi S. Novel insights into the effect of vitamin B12 and omega-3 fatty acids on brain function. J Biomed Sci 2016;23:17. doi: 10.1186/s12929-016-0241-8
  • Sujatha K, Srilatha CH, Chandhra TS, Sekhar Rao, Amaravathi P. Ultrastructural and histopathological studies in lead acetate induced neurotoxicity in wistar albino rats and its amelioration with ocimum sanctum (os) a leaf extract. Int J Pharma Bio Sci 2011;2(4):295–304.
  • Abdel Moneim AE, Dkhil MA, Al-Quraishy S. Effects of flaxseed oil on lead acetate-induced neurotoxicity in rats. Biol Trace Elem Res 2011;144:904–13. doi: 10.1007/s12011-011-9055-4
  • El-Masry Thanaa A, Emara Ashraf M, El-Shitany Nagla A. Possible protective effect of propolis against lead induced neurotoxicity in animal model. J Evol Biol Res 2011;3(1):4–11.
  • Seddik Bah TM, Aoues A, Benderdour M, Slimani M. Dried leaf extract protects against lead-induced neurotoxicity in wistar rats. Eur J Sci Res 2010;42:139–51.
  • Benlahcen K, Sansar W, Belhabri L, Slimani M. Lead in water: neurotoxicity and stressful effect on Wistar rat. Global J Environ Res 2009;3(1):52–60.
  • Meganathan M, Gopal KM, Sasikala P, Mohan J, Gowdhaman N, Balamurugan K, et al. Evaluation of hepatoprotective effect of omega 3-fatty acid against paracetamol induced liver injury in albino rats. Global J Pharmacol 2011;5(1):50–3.
  • El-Ansary AK, Al-Daihan SK, El-Gezeery AR. On the protective effect of omega-3 against propionic acid-induced neurotoxicity in rat pups. Lipids Health Dis 2011;10:142. doi: 10.1186/1476-511X-10-142
  • Abdel Moniem AE, Dkhil MA, Al-Quraishy S. Protective role of flaxseed oil against lead acetate induced oxidative stress in testes of adult rats. Afr J Biotechnol 2010;9(42):7216–23.
  • Hashimoto M, Tanabe Y, Fujii Y, Kikuta T, Shibata H, Osamu Shido. Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta–infused rats. J Nutr 2005;135:549–55. doi: 10.1093/jn/135.3.549
  • Lakhwani L, Tongia SK, Pal VS, Agrawal RP, Nyati P, Phadnis P. Omega-3 fatty acids have antidepressant activity in forced swimming test in wistar rats. Acta Pol Pharm-Drug Res 2007;64(3):271–6.
  • Zararsiz Ismail, Kus Ilter, Akpolat Nusret, Songur Ahmet, Ogeturk Murat, Sarsilmaz Mustafa. Protective effects of ω-3 essential fatty acids against formaldehyde-induced neuronal damage in prefrontal cortex of rats. Cell Biochem Funct 2006;24:237–44. doi: 10.1002/cbf.1204
  • Varvel SA, Lichtman AH. Evaluation of CB1 receptor knockout mice in the Morris water maze. Pharmacol Exp Ther 2002;301:915–24. doi: 10.1124/jpet.301.3.915
  • Broad Hurst PL. The place of animal psychology in the development of psychosomatic research. Fortschr Psychosom Med 1960;1:63–9.
  • Ali MM, Mathur N, Chandra SV. Effect of chronic cadmium exposure on locomotor activity of rats. Indian J Exp Biol 1990;28:653–6.
  • Yadav RS, Sankhwar ML, Shukla RK, Chandra R, Pant AB, Islam F, et al. Attenuation of arsenic neurotoxicity by curcumin in rats. Toxicol Appl Pharmacol 2009;240(3):367–76. doi: 10.1016/j.taap.2009.07.017
  • Terry AV Jr, Stone JD, Buccafusco JJ, Sickles DW, Sood A, Prendergast MA. Prendergast, repeated exposure to subthreshhold doses of chlorpyrifos in rats: hippocampal damage, impaired axonal transport and deficits in spatial learning. J Pharmacol Exp Ther 2003;305:375–84. doi: 10.1124/jpet.102.041897
  • Glowinski J, Iversen LL. Regional studies of catecholamines in the rat brain. I. The disposition of [3H] norepinephrine, [3H] dopamine and [3H] dopa in various regions of the brain. J Neurochem 1996;13:655–9. doi: 10.1111/j.1471-4159.1966.tb09873.x
  • Socci DJ, Bjugstad KB, Jones HC. Evidence that oxidative stress is associated with the pathophysiology of inherited hydrocephalus in the H-Tx rat model. Exp Neurol 1999;155:109–17. doi: 10.1006/exnr.1998.6969
  • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351–8. doi: 10.1016/0003-2697(79)90738-3
  • Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz AG, et al. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 1990;186:464–78. doi: 10.1016/0076-6879(90)86141-H
  • McCord JM, Fridovich I. Superoxide dismutase, an enzyme function for erythrocuprin (hemocuprin). J Biol Chem 1969;22:6049–55.
  • Aebi H. Catalase in vitro methods. Enzymol 1984;105:121–6. doi: 10.1016/S0076-6879(84)05016-3
  • Pagila DE, Valentine WN. Studies on the quantitation and qualitation characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967;70:158–69.
  • Ellman GL. Tissue sulfhydryl groups. Arch Biochem 1959;82:70–7. doi: 10.1016/0003-9861(59)90090-6
  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265–75.
  • Gupta V, Gill KD. Influence of ethanol on lead distribution and biochemical changes in rats exposed to lead. Alcohol 2000;20:9–17. doi: 10.1016/S0741-8329(99)00046-4
  • Suvarna SK, Layton C, Bancroft JD. Bancroft’s theory and practice of histological techniques. 7th ed. Nottingham: Churchill Livingstone; 2013.
  • Gandhi S, Abramov AY. Mechanism of oxidative stress in neurodegeneration. Oxidat Med Cell Longev 2012;2012:11. doi: 10.1155/2012/428010
  • Verina T, Rohde CA, Guilarte TR. Environmental lead exposure during early life alters granule cell neurogenesis and morphology in the hippocampus of young adult rats. Neurosci 2007;145(3):1037–47. doi: 10.1016/j.neuroscience.2006.12.040
  • Bazrgar M, Goudarzi I, Lashkarbolouki T, Salmani ME. Melatonin ameliorates oxidative damage induced by maternal lead exposure in rat pups. Physiol Behav 2015;151:178–88. doi: 10.1016/j.physbeh.2015.06.040
  • HyeJun Y, Inhye K, Sung-Hee K, Ju-Seop K, Ae-Son O. The protective effect of Chlorella vulgaris against lead-induced oxidative stress in rat brains. J Health Sci 2011;257:245–54.
  • Van den Berg KJ, Lammers JH, Hoogendijk EM, Kulig BM. Changes in regional brain GFAP levels and behavioral functioning following sub-chronic lead acetate exposure in adult rats. Neurotoxicol 1996;17:725–34.
  • Sharifi AM, Baniasadi S, Jorjani M, Rahimi F, Bakhshayesh M. Investigation of acute lead poisoning on apoptosis in rat hippocampus in vivo. Neurosci Lett 2002;329:45–8. doi: 10.1016/S0304-3940(02)00576-1
  • Ibrahim NM, Eweis EA, El-Beltagi HS, Abdel-Mobdy YE. Effect of lead acetate toxicity on experimental male albino rat. Asian Pac J Trop Biomed 2012;2(1):41–6. doi: 10.1016/S2221-1691(11)60187-1
  • Xu Y, Li G, Han C, Sun L, Zhao R, Cui S. Protective effects of Hippophaerhamnoides L. juice on lead-induced neurotoxicity in mice. Biol Pharm Bull 2005;28:490–4. doi: 10.1248/bpb.28.490
  • Shakila T, Hsiu-Jen W, Joshua WC, William AB, Nuran E. Effects of lead and cadmium on brain endothelial cell survival, monolayer permeability and crucial oxidative stress markers in an in vitro model of the blood-brain barrier. Toxics 2014;2:258–75. doi: 10.3390/toxics2020258
  • Adegbesan BO, Adenuga GA. Effect of lead exposure on liver lipid peroxidative and antioxidant defense systems of protein-undernourished rats. Biol Trace Elem Res 2007;116:219–25. doi: 10.1007/BF02685932
  • Flora SJ, Mittal M, Mehta A. Heavy metal induced oxidative stress & its possible reversal by chelation therapy. Indian J Med Res 2008;128:501–23.
  • Bagchi D, Vuchetich PJ, Bagchi M, Hassoun EA, Tran MX, Tang L, et al. Induction of oxidative stress by chronic administration of sodium dichromate [chromium vi] and cadmium chloride [cadmium II] to rats. Free Radic Biol Med 1997;22(3):471–8. doi: 10.1016/S0891-5849(96)00352-8
  • Bokara KK, Brown E, McCormick R, Yallapragada PR, Rajanna S, Bettaiya R. The lead-induced increase in antioxidant enzymes and lipid peroxidation products in developing rat brain. Biometals 2008;21(1):9–16. doi: 10.1007/s10534-007-9088-5
  • Li X, Ye F, Li L, Chang W, Wu X, Chen J. The role of HO-1 in protection against lead-induced neurotoxicity. Neurotoxicol 2016;52:1–11. doi: 10.1016/j.neuro.2015.10.015
  • Sekine S, Sasanuki S, Murano Y, Aoyama T, Takeuchi H. Alphalinolenic acid-rich flaxseed oil ingestion increases plasma adiponectin level in rats. Int J Vitam Nutr Res 2008;78:223–9. doi: 10.1024/0300-9831.78.45.223
  • Simopoulos AP. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 2002;56:365–79. doi: 10.1016/S0753-3322(02)00253-6
  • Dixit S, Dhar P, Mehra RD. Alpha lipoic acid (ALA) modulates expression of apoptosis-associated proteins in hippocampus of rats exposed during postnatal period to sodium arsenite (NaAsO2). Toxicol Rep 2015;2:78–87. doi: 10.1016/j.toxrep.2015.01.011
  • Ross SR, Lexin W, Herbert J. Erythrocyte oxidative damage in chronic fatigue syndrome. Arch Med Res 2007;38:94–8. doi: 10.1016/j.arcmed.2006.06.008
  • Bhatia AL, Sharma A, Patni S, Sharma AL. Prophylactic effect of flaxseed oil against radiation-induced hepatotoxicity in mice. Phytother Res 2007;21(9):852–85. doi: 10.1002/ptr.2169
  • Schaefer EJ, Bongard V, Beiser AS, Lamon-Fava S, Robins SJ, Au R, et al. Plasma phosphatidylcholinedocosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Arch Neurol 2006;63(11):1545–50. doi: 10.1001/archneur.63.11.1545
  • Bas O, Songur A, Sahin O, Mollaoglu H, Ozen OA, Yaman M, et al. The protective effect of fish oil n-3 fatty acids on cerebral ischemia in rat hippocampus. Neurochem Int 2007;50:548–54. doi: 10.1016/j.neuint.2006.11.005
  • Florent S, Malaplate-Armand C, Youssef I, Kriem B, Koziel V, Escanye MC, et al. Docosahexaenoic acid prevents neuronal apoptosis induced by soluble amyloid-beta oligomers. J Neurochem 2006;96(2):385–95. doi: 10.1111/j.1471-4159.2005.03541.x
  • Su P, Zhang J, Wang S, Aschner M, Cao Z, Zhao F, et al. Genistein alleviates lead-induced neurotoxicity in vitro and in vivo: involvement of multiple signaling pathways. Neurotoxicol 2016;53:153–64. doi: 10.1016/j.neuro.2015.12.019
  • Clasen RA, Hartmann JF, Coogan PS, Pandolfi S, Laing I, Becker RA. Experimental acute lead encephalopathy in the juvenile rhesus monkey. Environ Health Perspect 1974;7:175–85. doi: 10.1289/ehp.747175
  • Sidhu P, Nehru B. Lead intoxication: histological and oxidative damage in rat cerebrum and cerebellum. J Trace Elem Exp Med 2004;17:45–53. doi: 10.1002/jtra.10052
  • Hasadsri L, Wang BH, Lee JV, Erdman JW, Llano DA, Barbey AK, et al. Omega-3 fatty acids as a putative treatment for traumatic brain injury. J Neurotrauma 2013;30:897–906. doi: 10.1089/neu.2012.2672

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.