Publication Cover
Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 22, 2019 - Issue 3
241
Views
14
CrossRef citations to date
0
Altmetric
Articles

Downregulation of inflammatory markers by conjugated linoleic acid isomers in human cultured astrocytes

, ORCID Icon, , , , ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all

References

  • Escartin C, Bonvento G. Targeted activation of astrocytes: a potential neuroprotective strategy. Mol Neurobiol 2008;38(3):231–41.
  • Pizza V, Agresta A, D’Acunto CW, Festa M, Capasso A. Neuroinflamm-aging and neurodegenerative diseases: an overview. CNS Neurol Disord Drug Targets 2011;10(5):621–34.
  • Khanapure SP, Garvey DS, Janero DR, Letts LG. Eicosanoids in inflammation: biosynthesis, pharmacology, and therapeutic frontiers. Curr Top Med Chem 2007;7(3):311–40.
  • Desai A, Park T, Barnes J, Kevala K, Chen H, Kim HY. Reduced acute neuroinflammation and improved functional recovery after traumatic brain injury by alpha-linolenic acid supplementation in mice. J Neuroinflamm 2016;13(1):253.
  • Flock MR, Skulas-Ray AC, Harris WS, Gaugler TL, Fleming JA, Kris-Etherton PM. Effects of supplemental long-chain omega-3 fatty acids and erythrocyte membrane fatty acid content on circulating inflammatory markers in a randomized controlled trial of healthy adults. Prostaglandins Leukot Essent Fatty Acids 2014;91(4):161–8.
  • Dyall SC. Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA. Front Aging Neurosci 2015;7:52.
  • Griinari JM, Corl BA, Lacy SH, Chouinard PY, Nurmela KV, Bauman DE. Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by Delta(9)-desaturase. J Nutr 2000;130(9):2285–91.
  • Gaullier JM, Halse J, Hoye K, Kristiansen K, Fagertun H, Vik H, et al. Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. J Nutr 2005;135(4):778–84.
  • Kelley NS, Hubbard NE, Erickson KL. Conjugated linoleic acid isomers and cancer. J Nutr 2007;137(12):2599–607.
  • Moloney F, Toomey S, Noone E, Nugent A, Allan B, Loscher CE, et al. Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue. Diabetes 2007;56(3):574–82.
  • Reynolds CM, Draper E, Keogh B, Rahman A, Moloney AP, Mills KH, et al. A conjugated linoleic acid-enriched beef diet attenuates lipopolysaccharide-induced inflammation in mice in part through PPARgamma-mediated suppression of toll-like receptor 4. J Nutr 2009;139(12):2351–7.
  • Valeille K, Ferezou J, Parquet M, Amsler G, Gripois D, Quignard-Boulange A, et al. The natural concentration of the conjugated linoleic acid, cis-9,trans-11, in milk fat has antiatherogenic effects in hyperlipidemic hamsters. J Nutr 2006;136(5):1305–10.
  • Belury MA. Dietary conjugated linoleic acid in health: Physiological effects and mechanisms of action [Review]. Ann Rev Nutr 2002;22:505–31.
  • Carta G, Angioni E, Murru E, Melis MP, Spada S, Banni S. Modulation of lipid metabolism and vitamin A by conjugated linoleic acid. Prostaglandins Leukot Essent Fatty Acids 2002;67(2–3):187–91.
  • Fa M, Diana A, Carta G, Cordeddu L, Melis MP, Murru E, et al. Incorporation and metabolism of c9,t11 and t10,c12 conjugated linoleic acid (CLA) isomers in rat brain. Biochim Biophys Acta 2005;1736(1):61–6.
  • Cappa M, Bizzarri C, Petroni A, Carta G, Cordeddu L, Valeriani M, et al. A mixture of oleic, erucic and conjugated linoleic acids modulates cerebrospinal fluid inflammatory markers and improve somatosensorial evoked potential in X-linked adrenoleukodystrophy female carriers. J Inherit Metab Dis 2012;35(5):899–907.
  • Moya-Camarena SY, Vanden Heuvel JP, Blanchard SG, Leesnitzer LA, Belury MA. Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha. J Lipid Res 1999;40(8):1426–33.
  • Banni S, Angioni E, Casu V, Melis MP, Carta G, Corongiu FP, et al. Decrease in linoleic acid metabolites as a potential mechanism in cancer risk reduction by conjugated linoleic acid. Carcinogenesis 1999;20(6):1019–24.
  • Sartorius T, Drescher A, Panse M, Lastovicka P, Peter A, Weigert C, et al. Mice Lacking Free Fatty Acid Receptor 1 (GPR40/FFAR1) are Protected Against Conjugated Linoleic Acid-Induced Fatty Liver but Develop Inflammation and Insulin Resistance in the Brain. Cell Physiol Biochem 2015;35(6):2272–84.
  • Changhua L, Jindong Y, Defa L, Lidan Z, Shiyan Q, Jianjun X. Conjugated linoleic acid attenuates the production and gene expression of proinflammatory cytokines in weaned pigs challenged with lipopolysaccharide. J Nutr 2005;135(2):239–44.
  • Kim KH, Kim DI, Kim SH, Jung EM, Kang JH, Jeung EB, et al. Trans-10, cis-12-conjugated linoleic acid attenuates tumor necrosis factor-alpha production by lipopolysaccharide-stimulated porcine peripheral blood mononuclear cells through induction of interleukin-10. Cytokine 2011;56(2):224–30.
  • Yu Y, Correll PH, Vanden Heuvel JP. Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. Biochim Biophys Acta 2002;1581(3):89–99.
  • Gupta S, Knight AG, Gupta S, Keller JN, Bruce-Keller AJ. Saturated long-chain fatty acids activate inflammatory signaling in astrocytes. J Neurochem 2012;120(6):1060–71.
  • Cabras S, Saba F, Reali C, Scorciapino ML, Sirigu A, Talani G, et al. Antidepressant imipramine induces human astrocytes to differentiate into cells with neuronal phenotype. Int J Neuropsychopharmcol 2010;13(5):603–15.
  • Ennas MG, Cocchia D, Silvetti E, Sogos V, Riva A, Torelli S, et al. Immunocompetent cell markers in human fetal astrocytes and neurons in culture. J Neurosci Res 1992;32(3):424–36.
  • Spector AA, Hoak JC, Fry GL, Denning GM, Stoll LL, Smith JB. Effect of fatty acid modification on prostacyclin production by cultured human endothelial cells. J Clin Invest 1980;65(5):1003–12.
  • Banni S, Carta G, Angioni E, Murru E, Scanu P, Melis MP, et al. Distribution of conjugated linoleic acid and metabolites in different lipid fractions in the rat liver. J Lipid Res 2001;42(7):1056–61.
  • Banni S. Conjugated linoleic acid metabolism. Curr Opin Lipidol 2002;13(3):261–6.
  • Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipid from animal tissues. J Biol Chem 1957;226:497–509.
  • Banni S, Carta G, Contini MS, Angioni E, Deiana M, Dessi MA, et al. Characterization of Conjugated Diene Fatty Acids in Milk, Dairy Products, and Lamb Tissues. J Nutr Biochem 1996;7(3):150–5.
  • Melis MP, Angioni E, Carta G, Murru E, Scanu P, Spada S, et al. Characterization of conjugated linoleic acid and its metabolites by RP-HPLC with diode array detector. Eur J Lipid Sci Technol 2001;103(9):617–21.
  • Angioni E, Lercker G, Frega NG, Carta G, Melis MP, Murru E, et al. UV spectral properties of lipids as a tool for their identification. Eur J Lipid Sci Technol 2002;104(1):59–64.
  • Calder PC. Fatty acids and inflammation: the cutting edge between food and pharma. Eur J Pharmacol 2011;668(Suppl. 1):S50–8.
  • Iannone A, Petroni A, Murru E, Cordeddu L, Carta G, Melis MP, et al. Impairment of 8-iso-PGF(2ALPHA) isoprostane metabolism by dietary conjugated linoleic acid (CLA). Prostaglandins Leukot Essent Fatty Acids 2009;80(5–6):279–87.
  • de Waart DR, Koomen GC, Wanders RJ. Studies on the urinary excretion of thromboxane B2 in Zellweger patients and control subjects: evidence for a major role for peroxisomes in the beta-oxidative chain-shortening of thromboxane B2. Biochim Biophys Acta 1994;1226(1):44–8.
  • Diczfalusy U, Alexson SE. Identification of metabolites from peroxisomal beta-oxidation of prostaglandins. J Lipid Res 1990;31(2):307–14.
  • Ferdinandusse S, Meissner T, Wanders RJ, Mayatepek E. Identification of the peroxisomal beta-oxidation enzymes involved in the degradation of leukotrienes. Biochem Biophys Res Commun 2002;293(1):269–73.
  • Gama MA, Raposo NR, Mury FB, Lopes FC, Dias-Neto E, Talib LL, et al. Conjugated linoleic acid-enriched butter improved memory and up-regulated phospholipase A2 encoding-genes in rat brain tissue. J Neural Transm (Vienna) 2015;122(10):1371–80.
  • Wang J, Li G, Wang Z, Zhang X, Yao L, Wang F, et al. High glucose-induced expression of inflammatory cytokines and reactive oxygen species in cultured astrocytes. Neuroscience 2012;202:58–68.
  • Park KM, Bowers WJ. Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction. Cell Signal 2010;22(7):977–83.
  • Di Prisco S, Summa M, Chellakudam V, Rossi PI, Pittaluga A. RANTES-mediated control of excitatory amino acid release in mouse spinal cord. J Neurochem 2012;121(3):428–37.
  • Musante V, Longordo F, Neri E, Pedrazzi M, Kalfas F, Severi P, et al. RANTES modulates the release of glutamate in human neocortex. J Neurosci 2008;28(47):12231–40.
  • Aktan F. iNOS-mediated nitric oxide production and its regulation. Life Sci 2004;75(6):639–53.
  • Amitai Y. Physiologic role for “inducible” nitric oxide synthase: a new form of astrocytic-neuronal interface. Glia 2010;58(15):1775–81.
  • Ryan KK, Woods SC, Seeley RJ. Central nervous system mechanisms linking the consumption of palatable high-fat diets to the defense of greater adiposity. Cell Metab 2012;15(2):137–49.
  • Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 2008;135(1):61–73.
  • Soares JKB, de Melo APR, Medeiros MC, Queiroga RCRE, Bomfim MAD, Santiago ECA, et al. Anxiety behavior is reduced, and physical growth is improved in the progeny of rat dams that consumed lipids from goat milk: An elevated plus maze analysis. Neurosci Lett 2013;552:25–9.
  • Soares JK, Rocha-de-Melo AP, Medeiros MC, Queiroga RC, Bomfim MA, de Souza AF, et al. Conjugated linoleic acid in the maternal diet differentially enhances growth and cortical spreading depression in the rat progeny. Biochim Biophys Acta 2012;1820(10):1490–5.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.