References
- Araújo EP, Torsoni MA, Velloso LA. Hypothalamic inflammation and obesity. Vitam Horm 2010;82:129–43. doi:10.1016/S0083-6729(10)82007-2 doi: 10.1016/S0083-6729(10)82007-2
- Thaler JP, Yi C-X, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, et al. Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest 2012;122(1):153–62. doi:10.1172/JCI59660 doi: 10.1172/JCI59660
- Thaler JP, Schwartz MW. Inflammation and obesity pathogenesis: The hypothalamus heats up. Endocrinol 2010;151(9):4109–15. doi: 10.1210/en.2010-0336
- Buckman LB, Thompson MM, Moreno HN, Ellacott KLJ. Regional astrogliosis in the mouse hypothalamus in response to obesity. J Comp Neurol 2013;521:1322–33. doi:10.1002/cne.23233 doi: 10.1002/cne.23233
- Cai D. Neuroinflammation and neurodegenaration in overnutrition-induced dieases. Trends Endocrinol Metab 2013;24(1):40–7. doi:10.1016/j.tem.2012.11.003 doi: 10.1016/j.tem.2012.11.003
- Garcia-Cáceres C, Yi C-X, Tschöp MH. Hypothalamic astrocytes in obesity. Endocrinol Metab Clin N Am 2013;42:57–66. doi:10.1016/j.ecl.2012.11.003 doi: 10.1016/j.ecl.2012.11.003
- Maric T, Woodside B, Luheshi GN. The effects of dietary saturated fat on basal hypothalamic neuroinflammation in rats. Brain Behav Immun 2014;36:35–45. doi: 10.1016/j.bbi.2013.09.011
- Becksei C, Riediger T, Hernádfaly N, Arsenijevic D, Lutz TA, Langhans W. Inhibitory effects of lipopolysaccharide on hypothalamic nuclei implicated in the control of food intake. Brain Behav Immun 2008;22:56–64. doi:10.1016/j.bbi.2007.06.002 doi: 10.1016/j.bbi.2007.06.002
- Chowen JA, Argente J, Horvath TL. Uncovering novel roles of nonneuronal cells in body weight homeostasis and obesity. Endocrinol 2013;154(9):3001–7. doi:10.1210/en.2013-1303 doi: 10.1210/en.2013-1303
- Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. Acta Neuropathol 2010;119:7–35. doi:10.1007/s00401-009-0619-8 doi: 10.1007/s00401-009-0619-8
- Pekny M, Pekna A. Astrocyte intermediate filaments in CNS pathologies and regeneration. J Pathol 2004;204:428–37. doi:10.1002/path.1645 doi: 10.1002/path.1645
- Sofroniew MV. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci 2009;32:638–47. doi:10.1016/j.tins.2009.08.002 doi: 10.1016/j.tins.2009.08.002
- Cregg JC, DePaul MA, Filous AR, Lang GBT, Tran A, Silver J. Functional regeneration beyond glial scar. Exp Neurol 2014;253:197–207. doi:10.1016/j.expneurol.2013.12.024 doi: 10.1016/j.expneurol.2013.12.024
- Thaler JP, Guyenet SJ, Dorfman MD, Wisse BE, Schwartz MW. Hypothalamic inflammation: marker or mechanism of obesity pathogenesis. Diabetes 2013;62:2629–34. doi: 10.2337/db12-1605
- Joaquim AO, Coelho CP, Dias-Motta PD, Felício LF, Bondan EF, Teodorov E, et al. Maternal food deprivation in rats of the F0 generation increases retroperitoneal fat, the number and size of adipocytes and induces periventricular astrogliosis in female F1 and male F2 generations. Reprod Fertil Dev 2017;29(7):1340–8. doi:10.1071/RD15309 doi: 10.1071/RD15309
- Ogassawara TB, Joaquim A, Coelho CP, Bernardi MM, Teodorov E, Martins MFM, et al. Food deprivation in F0 generation and hypercaloric diet in F1 generation reduce F2 generation astrogliosis in several brain areas after immune challenge. Int J Dev Neurosci 2018;64:29–37. doi:10.1016/j.ijdevneu.2017.06.003 doi: 10.1016/j.ijdevneu.2017.06.003
- Li M, Sloboda DM, Vickers MH. Maternal obesity and developmental programming of metabolic disorders in offspring: 40 evidence from animal models. Exp Diabetes Res 2011;592408. doi:10.1155/2011/592408.
- Vickers MH. Developmental programming and transgenerational transmission of obesity. ANN Nutr Metab 2014;64(suppl 1):26–34. doi: 10.1159/000360506
- Ross MG, Desai M. Developmental programming of offspring obesity, adipogenesis, and appetite. Clin Obstet Gynecol 2013;56:529–36. doi:10.1097/GRF.0B013E318299C39D doi: 10.1097/GRF.0b013e318299c39d
- Taylor PD, Poston L. Developmental programming of obesity in mammals. Exp Physiol 2007;92:287–98. doi:10.1113/EXPPHYSIOL.2005.032854 doi: 10.1113/expphysiol.2005.032854
- Joaquim AO, Coelho CP, Motta PD, Bondan EF, Teodorov E, Martins MFM, et al. Transgenerational effects of a hypercaloric diet. Reprod Fertil Dev 2015;29(2):325–35. doi:10.1071/RD15165 doi: 10.1071/RD15165
- DeSantis DT, Schmaltz LW. The mother-litter relationship in developmental rat studies: cannibalism vs caring. Dev Psychobiol 1984;17:255–62. doi:10.1002/dev.420170306 doi: 10.1002/dev.420170306
- Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 7th ed. New York: Academic Press; 2013. 472 p.
- Wajchenberg BL. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocrine Rev 2000;21(6):697–738. doi:10.1210/edrv.21.6.0415 doi: 10.1210/edrv.21.6.0415
- Chandra A, Neeland IJ, Berry JD, Ayers CR, Rohatgi A, Das SR, et al. The relationship of body mass and fat distribution with incident hypertension observations from the Dallas Heart Study. J Am Coll Cardiol 2014;64(10):997–1002. doi:10.1016/j.jacc.2014.05.057 doi: 10.1016/j.jacc.2014.05.057
- Hung C-S, Lee J-K, Yang C-Y, Hsieh H-R, Ma W-Y, Lin M-S, et al. Measurement of visceral fat: should we include retroperitoneal fat? PLoS One 2014;9(11):e112355. doi:10.1371/journal.pone.0112355 doi: 10.1371/journal.pone.0112355
- Alvehus M, Burén J, Sjöström M, Goedecke J, Olsson T. The human visceral fat depot has a unique inflammatory profile. Obesity 2010;18(5):879–83. doi:10.1038/oby.2010.22 doi: 10.1038/oby.2010.22
- Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity linked insulin resistance. Science 1993;259(5091):87–91. doi: 10.1126/science.7678183
- Wen X, Pekkala S, Wang R, Wiklund P, Feng G, Cheng S M, et al. Does systemic low-grade inflammation associate with fat accumulation and distribution? A 7-year follow-up study with peripubertal girls. J Clin Endocrinol Metab 2014;99:1411–9. doi:10.1210/JC.2013-3267 doi: 10.1210/jc.2013-3267
- Marcovecchio ML, Chiarelli F. Obesity and growth during childhood and puberty. World Rev Nutr Diet 2013;106:135–41. doi:10.1159/000342545 doi: 10.1159/000342545
- Lemus MB, Bayliss JA, Lockie SH, Santos VV, Reichenbach A, Stark R, et al. A stereological analysis of NPY, POMC, Orexin, GFAP astrocyte, and Iba1 microglia cell number and volume in diet-induced obese male mice. Endocrinol 2015;156(5):1701–13. doi:10.1210/en.2014-1961 doi: 10.1210/en.2014-1961
- Yang Z, Wang KW. Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker. Trends Neurosc 2015;38(6):364–74. doi:10.1016/j.tins.2015.04.003 doi: 10.1016/j.tins.2015.04.003
- Middeldorp J, Hol EM. GFAP in health and disease. Prog Neurobiol 2011;93:421–3. doi:10.1016/j.pneurobio.2011.01.005 doi: 10.1016/j.pneurobio.2011.01.005
- Hsuchou H, He Y, Katin AJ, Tu H, Markadakis EN, Rogers RC, et al. Obesity induces functional astrocytic leptin receptors in the hypothalamus. Brain 2009;132:889–902. doi: 10.1093/brain/awp029
- Pan W, Hsuchou H, Xu C, Wu X, Bouret SG, Kastin AJ. Astrocytes modulate distribution and neuronal signaling of leptin in the hypothalamus of obese Avy mice. J Mol Neurosci 2011;43(3):478–84. doi:10.1007/s12031-010-9470-6 doi: 10.1007/s12031-010-9470-6
- Horvath TL, Sarman B, García-Cáceres C, Enriori PJ, Sotonyi P, Shanabrough M, et al. Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. Proc Natl Acad Sci USA 2010;107(33):14875–80. doi:10.1073/pnas.1004282107 doi: 10.1073/pnas.1004282107
- Gupta S, Knight AG, Gupta S, Keller JN, Bruce-Keller AJ. Saturated long chain fatty acids activate inflammatory signaling in astrocytes. J Neurochem 2012;120:1060–171. doi:10.1111/j.1471-4159.2012.07660.x.
- Miller AA, Spencer SJ. Obesity and neuroinflammation: a pathway to cognitive impairment. Brain Behav Immun 2014;42:10–21. doi:10.1016/j.bbi.2014.04.001 doi: 10.1016/j.bbi.2014.04.001
- Jais A, Brüning JC. Hypothalamic inflammation in obesity and metabolic disease. J Clin Invest 2017;127:24–32. doi: 10.1172/JCI88878