Publication Cover
Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 24, 2021 - Issue 2
1,191
Views
61
CrossRef citations to date
0
Altmetric
Articles

Sesamin and sesamol attenuate H2O2-induced oxidative stress on human neuronal cells via the SIRT1-SIRT3-FOXO3a signaling pathway

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon

References

  • Association As. 2017 Alzheimer’s disease facts and figures. Alzheimers Dement. 2017;13(4):325–73. doi: 10.1016/j.jalz.2017.02.001
  • Prince M, Wimo A, Guerchet M, Ali GC, Wu YT, Prina M. Prina M. World Alzheimer report 2015. The global impact of dementia. London: Alzheimer's Disease International (ADI); 2015. p. 1–87.
  • Prince M, Herrera AC, Knapp M, Guerchet M, Karagiannidou M, World Alzheimer Report 2016. Improving healthcare for people living with dementia. London: Alzheimer’s Disease International (ADI); 2016; p. 1–140.
  • Emerit J, Edeas M, Bricaire F. Neurodegenerative diseases and oxidative stress. Biomed Pharmacother. 2004;58(1):39–46. doi: 10.1016/j.biopha.2003.11.004
  • Liu X, Kim CN, Yang J, Jemmerson R, Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell. 1996;86(1):147–57. doi: 10.1016/S0092-8674(00)80085-9
  • Portt L, Norman G, Clapp C, Greenwood M, Greenwood MT. Anti-apoptosis and cell survival: a review. Biochim Biophys Acta. 2011;1813(1):238–59. doi: 10.1016/j.bbamcr.2010.10.010
  • Feige JN, Auwerx J. Transcriptional targets of sirtuins in the coordination of mammalian physiology. Curr Opin Cell Biol. 2008;20(3):303–309. doi: 10.1016/j.ceb.2008.03.012
  • Prachayasittikul V, Prachayasittikul S, Ruchirawat S, Prachayasittikul V. Coriander (Coriandrum sativum): a promising functional food toward the well-being. Food Res Int. 2018;105:305–23. doi: 10.1016/j.foodres.2017.11.019
  • Mahendra Kumar C, Singh SA. Bioactive lignans from sesame (Sesamum indicum L.): evaluation of their antioxidant and antibacterial effects for food applications. J Food Sci Technol. 2015;52(5):2934–41. doi: 10.1007/s13197-014-1334-6
  • Hans S, Sharma S, Hameed S, Fatima Z. Sesamol exhibits potent antimycobacterial activity: underlying mechanisms and impact on virulence traits. J Glob Antimicrob Resist. 2017;10:228–37. doi: 10.1016/j.jgar.2017.06.007
  • Dou H, Yang S, Hu Y, Xu D, Liu L, Li X. Sesamin induces ER stress-mediated apoptosis and activates autophagy in cervical cancer cells. Life Sci. 2018;200:87–93. doi: 10.1016/j.lfs.2018.03.003
  • Liu Z, Ren B, Wang Y, Zou C, Qiao Q, Diao Z, et al. Sesamol induces human hepatocellular carcinoma cells apoptosis by impairing mitochondrial function and suppressing autophagy. Sci Rep. 2017;7:45728. doi: 10.1038/srep45728
  • Bhardwaj R, Sanyal SN, Vaiphei K, Kakkar V, Deol PK, Kaur IP, et al. Sesamol induces apoptosis by altering expression of Bcl-2 and Bax proteins and modifies skin tumor development in Balb/c mice. Anticancer Agents Med Chem. 2017;17(5):726–33. doi: 10.2174/1871520616666160819103249
  • Liu N, Wu C, Sun L, Zheng J, Guo P. Sesamin enhances cholesterol efflux in RAW264.7 macrophages. Molecules. 2014;19(6):7516–27. doi: 10.3390/molecules19067516
  • Wu XL, Liou CJ, Li ZY, Lai XY, Fang LW, Huang WC. Sesamol suppresses the inflammatory response by inhibiting NF-kappaB/MAPK activation and upregulating AMP kinase signaling in RAW 264.7 macrophages. Inflamm Res. 2015;64(8):577–88. doi: 10.1007/s00011-015-0836-7
  • Gandhi S, Abramov AY. Mechanism of oxidative stress in neurodegeneration. Oxid Med Cell Longev. 2012;2012:1–11. doi: 10.1155/2012/428010
  • Kiran K, Asad M. Wound healing activity of Sesamum indicum L. seed and oil in rats. Indian J Exp Biol. 2008;46(11):777–82.
  • Asgary S, Rafieian Kopaei M, Najafi S, Heidarian E, Sahebkar A. Antihyperlipidemic effects of Sesamum indicum L. in rabbits fed a high-fat diet. Sci World J. 2013;2013:1–5. doi: 10.1155/2013/365892
  • Suwimol S, Wiroj J, Kewalin W, Natchapon J, Pathamaporn H, Auranun S. Effects of sesame seeds consumption on serum cholesterol and oxidative status in hypercholesterolemia. SAP. 2012;2(6):193–96.
  • Khani B, Bidgoli SR, Moattar F, Hassani H. Effect of sesame on sperm quality of infertile men. J Res Med Sci. 2013;18(3):184–87.
  • Korac RR, Khambholja KM. Potential of herbs in skin protection from ultraviolet radiation. Pharmacogn Rev. 2011;5(10):164–73. doi: 10.4103/0973-7847.91114
  • Goluch Koniuszy ZS. Nutrition of women with hair loss problem during the period of menopause. Prz Menopauzalny. 2016;15(1):56–61.
  • Takemoto D, Yasutake Y, Tomimori N, Ono Y, Shibata H, Hayashi J. Sesame lignans and vitamin E supplementation improve subjective statuses and anti-oxidative capacity in healthy humans with feelings of daily fatigue. Glob J Health Sci. 2015;7(6):1–10. doi: 10.5539/gjhs.v7n6p1
  • Picone P, Nuzzo D, Caruana L, Scafidi V, Di Carlo M. Mitochondrial dysfunction: different routes to Alzheimer’s disease therapy. Oxid Med Cell Longev. 2014;2014:1–11. doi: 10.1155/2014/780179
  • Canto C, Gerhart Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, et al. Ampk regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. 2009;458(7241):1056–60. doi: 10.1038/nature07813
  • Haigis MC, Yankner BA. The aging stress response. Mol Cell. 2010;40(2):333–44. doi: 10.1016/j.molcel.2010.10.002
  • Ng F, Wijaya L, Tang BL. Sirt1 in the brain—connections with aging-associated disorders and lifespan. Front Cell Neurosci. 2015;9:64.
  • Gay NH, Phopin K, Suwanjang W, Ruankham W, Wongchitrat P, Prachayasittikul S, et al. Attenuation of oxidative stress-induced neuronal cell death by Hydnophytum formicarum Jack. Asian Pac J Trop Med. 2018;11(7):415–22. doi: 10.4103/1995-7645.237185
  • Gay NH, Phopin K, Suwanjang W, Songtawee N, Ruankham W, Wongchitrat P, et al. Neuroprotective effects of phenolic and carboxylic acids on oxidative stress-induced toxicity in human neuroblastoma SH-SY5Y cells. Neurochem Res. 2018;48(3):619–36.
  • Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, et al. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature. 2002;419(6904):316–21. doi: 10.1038/nature01036
  • Kim AD, Kang KA, Piao MJ, Kim KC, Zheng J, Yao CW, et al. Cytoprotective effect of eckol against oxidative stress-induced mitochondrial dysfunction: involvement of the FoxO3a/AMPK pathway. J Cell Biochem. 2014;115(8):1403–11. doi: 10.1002/jcb.24790
  • de la Lastra CA, Villegas I. Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications. Biochem Soc Trans. 2007;35(5):1156–60. doi: 10.1042/BST0351156
  • Martín AR, Villegas I, Sánchez Hidalgo M, de la Lastra CA. The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model. Br J Pharmacol. 2006;147(8):873–85. doi: 10.1038/sj.bjp.0706469
  • Suja KP, Jayalekshmy A, Arumughan C. Free radical scavenging behavior of antioxidant compounds of sesame (Sesamum indicum L.) in DPPH• system. J Agric Food Chem. 2004;52(4):912–15. doi: 10.1021/jf0303621
  • Bopitiya D, Madhujith T. Antioxidant activity and total phenolic content of sesame (Sesamum indicum L.) seed oil. Trop Agric Res. 2015;24(3):296–302. doi: 10.4038/tar.v24i3.8015
  • Yeo J, Park J, Lee J. Evaluation of antioxidant capacity of sesamol and free radical scavengers at different heating temperatures. Eur J Lipid Sci Technol. 2011;113(7):910–15. doi: 10.1002/ejlt.201000553
  • Geetha T, Rohit B, Pal KI. Sesamol: an efficient antioxidant with potential therapeutic benefits. Med Chem. 2009;5(4):367–71. doi: 10.2174/157340609788681476
  • Yeo JD, Jeong MK, Park CU, Lee J. Comparing antioxidant effectiveness of natural and synthetic free radical scavengers in thermally-oxidized lard using DPPH method. J Food Sci. 2010;75(3):C258–62. doi: 10.1111/j.1750-3841.2010.01534.x
  • Hou RC, Huang HM, Tzen JT, Jeng KC. Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells. J Neurosci Res. 2003;74(1):123–33. doi: 10.1002/jnr.10749
  • Saleem MTS, Chetty MC, Kavimani S. Putative antioxidant property of sesame oil in an oxidative stress model of myocardial injury. J Cardiovasc Dis Res. 2013;4(3):177–81. doi: 10.1016/j.jcdr.2013.07.001
  • Kincaid B, Bossy Wetzel E. Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. Front Aging Neurosci. 2013;5:48. doi: 10.3389/fnagi.2013.00048
  • Jacobs KM, Pennington JD, Bisht KS, Aykin Burns N, Kim HS, Mishra M, et al. Sirt3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci. 2008;4(5):291–99. doi: 10.7150/ijbs.4.291
  • Tao R, Coleman MC, Pennington JD, Ozden O, Park SH, Jiang H, et al. Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol Cell. 2010;40(6):893–904. doi: 10.1016/j.molcel.2010.12.013
  • Bournival J, Plouffe M, Renaud J, Provencher C, Martinoli MG. Quercetin and sesamin protect dopaminergic cells from MPP+-induced neuroinflammation in a microglial (N9)-neuronal (PC12) coculture system. Oxid Med Cell Longev. 2012;2012:1–11. doi: 10.1155/2012/921941
  • Lahaie Collins V, Bournival J, Plouffe M, Carange J, Martinoli MG. Sesamin modulates tyrosine hydroxylase, superoxide dismutase, catalase, inducible NO synthase and interleukin-6 expression in dopaminergic cells under MPP(+)-induced oxidative stress. Oxid Med Cell Longev. 2008;1(1):54–62. doi: 10.4161/oxim.1.1.6958
  • Zhang M, Lee HJ, Park KH, Park HJ, Choi HS, Lim SC, et al. Modulatory effects of sesamin on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Neuropharmacology. 2012;62(7):2219–26. doi: 10.1016/j.neuropharm.2012.01.012
  • Bournival J, Francoeur MA, Renaud J, Martinoli MG. Quercetin and sesamin protect neuronal PC12 cells from high-glucose-induced oxidation, nitrosative stress, and apoptosis. Rejuvenation Res. 2012;15(3):322–33. doi: 10.1089/rej.2011.1242
  • Baluchnejadmojarad T, Mansouri M, Ghalami J, Mokhtari Z, Roghani M. Sesamin imparts neuroprotection against intrastriatal 6-hydroxydopamine toxicity by inhibition of astroglial activation, apoptosis, and oxidative stress. Biomed Pharmacother. 2017;88:754–61. doi: 10.1016/j.biopha.2017.01.123
  • Sachdeva AK, Misra S, Pal Kaur I, Chopra K. Neuroprotective potential of sesamol and its loaded solid lipid nanoparticles in ICV-STZ-induced cognitive deficits: behavioral and biochemical evidence. Eur J Pharmacol. 2015;747:132–40. doi: 10.1016/j.ejphar.2014.11.014

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.