References
- Konar A, Singh P, Thakur MK. Age-associated cognitive decline: insights into molecular switches and recovery avenues. Aging Dis. 2016;7:121–9.
- Yousef H, Morgenthaler A, Schlesinger C, Bugaj L, Conboy IM, Schaffer DV. Age-associated increase in BMP signaling inhibits hippocampal neurogenesis. Stem Cells. 2015;33(5):1577–88.
- Galvan V, Jin K. Neurogenesis in the aging brain. Clin Interv Aging. 2007;2(4):605–10.
- Hattiangady B, Rao MS, Shetty GA, Shetty AK. Brain-derived neurotrophic factor, phosphorylated cyclic AMP response element binding protein and neuropeptide Y decline as early as middle age in the dentate gyrus and CA1 and CA3 subfields of the hippocampus. Exp Neurol. 2005;195:353–71.
- Rafieva LM, Gasanov EV. Neurotrophin propeptides: biological functions and molecular mechanisms. Curr Protein Pept Sci. 2016;17:298–305.
- Cao X, Fang Y. Transducing oxidative stress to death signals in neurons. J Cell Biol. 2015;211(4):741–3.
- Paradies G, Paradies V, Ruggiero FM, Petrosillo G. Mitochondrial bioenergetics decay in aging: beneficial effect of melatonin. Cell Mol Life Sci. 2017;74(21):3897–911.
- Haider S, Saleem S, Perveen T, Tabassum S, Batool Z, Sadir S, et al. Age-related learning and memory deficits in rats: role of altered brain neurotransmitters, acetylcholinesterase activity and changes in antioxidant defense system. Age (Omaha). 2014;36(3):9653.
- Cui X, Gooch H, Petty A, Mc Grath JJ, Eyles D. Vitamin D and the brain: Genomic and non-genomic actions. Mol Cell Endocrinol. 2017;453:131–43.
- Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008;87(4):1080–6.
- van Schoor NM, Comijs HC, Llewellyn DJ, Lips P. Cross-sectional and longitudinal associations between serum 25-hydroxyvitamin D and cognitive functioning. Int Psychogeriatr. 2016;28(5):759–68.
- Di Somma C, Scarano E, Barrea L, Zhukouskaya VV, Savastano S, Mele C, et al. Vitamin D and neurological diseases: an endocrine view. Int J Mol Sci. 2017;18(11):2482.
- Berridge MJ. Vitamin D deficiency accelerates ageing and age-related diseases: a novel hypothesis. J Physiol. 2017;595(22):6825–36.
- Briones TL, Darwish H. Vitamin D mitigates age-related cognitive decline through the modulation of pro-inflammatory state and decrease in amyloid burden. J Neuroinflammation. 2012;9:244. doi: 10.1186/1742-2094-9-244
- Latimer CS, Brewer LD, Searcy JL, Chen KC, Popovic J, Kraner SD, et al. Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats. Proc Natl Acad Sci USA. 2014;111(41):4359–66.
- Hajiluian G, Nameni G, Shahabi P, Mesgari-Abbasi M, Sadigh-Eteghad S, Farhangi MA. Vitamin D administration, cognitive function, BBB permeability and neuroinflammatory factors in high-fat diet-induced obese rats. Int J Obes (Lond). 2017;41(4):639–44.
- Zerwekh JE. Blood biomarkers of vitamin D status. Am J Clin Nutr. 2008;87(4):1087–91.
- Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem. 1951;193:265–75.
- Schulze J, Kaiser O, Paasche G, Lamm H, Pich A, Hoffmann A, et al. Effect of hyperbaric oxygen on BDNF-release and neuroprotection: Investigations with human mesenchymal stem cells and genetically modified NIH3T3 fibroblasts as putative cell therapeutics. PLoS ONE. 2017;12(5):e0178182.
- Ellman CL, Courtney D, Andres V, Featherstone R. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961;7:88–95.
- Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Bio Chem. 1975;95:351–8.
- Goldberg DM, Spooner RJ. Assay of glutathione reductase. In: Bergmeyer HU, editor. Methods of enzymatic analysis. 3rd ed., Vol. 3. Dearfield Beach: Verlag Chemie; 1983, p. 258–65.
- Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967;70(1):158–69.
- Nishikimi M, Roa NA, Yogi K. Colorimetric method assay for superoxide dismutase. Biochem Biophys Res Commun. 1972;46:849–54.
- Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 1995;376:37–43.
- Ziegenhorn AA, Schulte-Herbrüggen O, Danker-Hopfe H, Malbranc M, Hartung HD, Anders D, et al. Serum neurotrophins—a study on the time course and influencing factors in a large old age sample. Neurobiol Aging. 2007;28:1436–45.
- Siuda J, Patalong-Ogiewa M, Żmuda W, Targosz-Gajniak M, Niewiadomska E, Matuszek I, et al. Cognitive impairment and BDNF serum levels. Neurol Neurochir Pol. 2017;51(1):24–32.
- Calabrese F, Guidotti G, Racagni G, Riva MA. Reduced neuroplasticity in aged rats: a role for the neurotrophin brain-derived neurotrophic factor. Neurobiol Aging. 2013;34(12):2768–76.
- Adlard PA, Perreau VM, Cotman CW. The exercise-induced expression of BDNF within the hippocampus varies across life-span. Neurobiol Aging. 2005;26:511–20.
- Bimonte H, Granholm AC, Nelson M, Moore A. Patterns of neurotrophin protein levels in male and female Fischer 344 rats from adulthood to senescence: How young is ‘young’ and how old is ‘old’? Exp Aging Res. 2008;34(1):13–26.
- Scharfman H, Goodman J, Macleod A, Phani S, Antonelli C, Croll S. Increased neurogenesis and the ectopic granule cells after intra-hippocampal BDNF infusion in adult rats. Exp Neurol. 2005;192:348–56.
- Nagatsu T, Sawada M. Inflammatory process in Parkinsons disease: role for cytokines. Curr Pharm Des. 2005;11(8):999–1016.
- Mohamed AR, Soliman GY, Ismail CA, Manaa HF. Neuroprotective role of vitamin D3 in colchicine-induced Alzheimer’s disease in rats. Alex J Med. 2015;51(2):127–36.
- Johansson P, Almqvist E G, Johansson J O, Mattsson N, Andreasson U, Hansson O, et al. Cerebrospinal fluid (CSF) 25-hydroxyvitamin D concentration and CSF acetylcholinesterase activity are reduced in patients with Alzheimer's disease. PLoS ONE. 2013;8:e81989.
- Stio M, Celli A, Treves C. Synergistic anti-proliferative effects of vitamin D derivatives and 9-cis retinoic acid in SH-SY5Y human neuroblastoma cells. J Steroid Biochem Mol Biol. 2001;77(4–5):213–22.
- Calgaroto NS, Thomé GR, da Costa P, Baldissareli J, Hussein FA, Schmatz R, et al. Effect of vitamin D3 on behavioural and biochemical parameters in diabetes type 1-induced rats. Cell Biochem Funct. 2014;32(6):502–10.
- Amenta F, Tayebati SK. Pathways of acetylcholine synthesis, transport and release as targets for treatment of adult-onset cognitive dysfunction. Curr Med Chem. 2008;15(5):488–98.
- Annweiler C. Vitamin D in dementia prevention. Ann N Y Acad Sci. 2016;1367:57–63.
- Sakata K, Overacre AE. Promoter iv-BDNF deficiency disturbs cholinergic gene expression of CHRNA5, CHRM2, and CHRM5: effects of drug and environmental treatments. J Neurochem. 2017;143(1):49–64.
- Taskiris S, Angelogianni P, Schulpis KH, Stavridis JC. Protective effect of L-phenylalanine on rat brain acetylcholinesterase inhibition induced by free radicals. Clin Biochem. 2000;33:103–6.
- Lin AM, Chen KB, Chao PL. Antioxidative effects of vitamin D3 on zinc-induced oxidative stress in CNS. Ann N Y Acad Sci. 2005;1053:319–29.
- Long I, Gao F, Tong L, Cotman CW, Ames BN, Liu I. Mitochondrial decay in the brains of old rats: ameliorating effect of α- lipoic acid and acetyl-L-carnitine. Neurochem Res. 2009;34:755–63.
- Harman D. Free radical theory of aging: an update: increasing the functional life span. Ann N Y Acad Sci. 2006;1067:10–2.
- Enciu AM, Gherghiceanu M, Popescu BO. Triggers and effectors of oxidative stress at blood-brain barrier level: relevance for brain ageing and neurodegeneration. Oxid Med Cell Longev. 2013;297512. doi:10.1155/2013/297512.
- BaSalamah MA, Abdelghany AH, El-Boshy M, Ahmad J, Idris S, Refaat B. Vitamin D alleviates lead induced renal and testicular injuries by immunomodulatory and antioxidant mechanisms in rats. Sci Rep. 2018;8:4853.
- Garcion E, Wion-Barbot N, Montero-Menei C, Berger F, Wion D. New clues about vitamin D in the nervous system. Trends Endocrinol Metab. 2002;13:100–5.
- Ryan ZC, Craig TA, Folmes CD, Wang X, Lanza IR, Schaible NS, et al. 1α,25-Dihydroxyvitamin d3 regulates mitochondrial oxygen consumption and dynamics in human skeletal muscle cells. J Biol Chem. 2016;291:1514–28.
- Caccamo D, Ricca S, Currò M, Ientile R. Health risks of hypovitaminosis D: a review of new molecular insights. Int J Mol Sci. 2018;19(3):892.
- Garbarino VR, Orr ME, Rodriguez KA, Buffenstein R. Mechanisms of oxidative stress resistance in the brain: Lessons learned from hypoxia tolerant extremophilic vertebrates. Arch Biochem Biophys. 2015;576:8–16.
- Zhang Y, Chong E, Herman B. Age-associated increases in the activity of multiple caspases in Fisher 344 rat organs. Exp Gerontol. 2002;37:777–89.
- Kim SE, Ko IG, Kim BK, Shin MS, Cho S, Kim CJ, et al. Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus. Exp Gerontol. 2010;45(5):357–65.
- Squier TC, Bigelow DJ. Protein oxidation and age-dependent alterations in calcium homeostasis. Front Biosci. 2000;5:504–26.
- Toman J, Fiskum G. Influence of aging on membrane permeability transition in brain mitochondria. J Bioenerg Biomembr. 2011;43(1):3–10.
- Niizuma K, Yoshioka H, Chen H, Kim GS, Jung JE, Katsu M, et al. Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia. Biochim Biophys Acta. 2010;1802(1):92–9.
- Mattson MP. Neuronal life-and-death signaling, apoptosis, and neurodegenerative disorders. Antioxid Redox Signal. 2006;8:1997–2006.
- Cui C, Song S, Cui J, Feng Y, Gao J, Jiang P. Vitamin D receptor activation influences NADPH oxidase (NOX(2)) activity and protects against neurological deficits and apoptosis in a rat model of traumatic brain injury. Oxid Med Cell Longev. 2017;2017:9245702.
- Dursun E, Gezen-Ak D, Yilmazer S. A novel perspective for Alzheimer's disease: vitamin D receptor suppression by amyloid-β and preventing the amyloid-β induced alterations by vitamin D in cortical neurons. J Alzheimers Dis. 2011;23(2):207–19.
- Markham A, Cameron I, Bains R, Franklin P, Kiss JP, Schwendimann L, et al. Brain-derived neurotrophic factor-mediated effects on mitochondrial respiratory coupling and neuroprotection share the same molecular signalling pathways. Eur J Neurosci. 2012;35(3):366–74.
- Bui NT, Konig HG, Culmsee C, Bauerbach E, Poppe M, Krieglstein J, Prehn JH. P75 neurotrophin receptor is required for constitutive and NGF-induced survival signalling in PC12 cells and rat hippocampal neurones. J Neurochem. 2002;81:594–605.
- Florez-McClure ML, Linseman DA, Chu CT, Barker PA, Bouchard RJ, Le SS, et al. The p75 neurotrophin receptor can induce autophagy and death of cerebellar Purkinje neurons. J Neurosci. 2004;24(19):4498–509.