References
- Zhu ST, Noviello CM, Teng JF, Walsh RM, Kim JJ, Hibbs RE. Structure of a human synaptic GABA(A) receptor. Nature. 2018;559(7712):67–72. doi: https://doi.org/10.1038/s41586-018-0255-3
- Miller PS, Aricescu AR. Crystal structure of a human GABAA receptor. Nature. 2014;512(7514):270–75. doi: https://doi.org/10.1038/nature13293
- Cossart R, Bernard C, Ben-Ari Y. Multiple facets of GABAergic neurons and synapses: multiple fates of GABA signalling in epilepsies. Trends Neurosci. 2005;28(2):108–15. doi: https://doi.org/10.1016/j.tins.2004.11.011
- Braestrup C, Schmiechen R, Neef G, Nielsen M, Petersen EN. Interaction of convulsive ligands with benzodiazepine receptors. Science. 1982;216(4551):1241–43. doi: https://doi.org/10.1126/science.6281892
- Mohler H, Okada T. Benzodiazepine receptor: demonstration in the central nervous system. Science. 1977;198(4319):849–51. doi: https://doi.org/10.1126/science.918669
- Borja NL, Daniel KL. Ramelteon for the treatment of insomnia. Clin Ther. 2006;28(10):1540–55. doi: https://doi.org/10.1016/j.clinthera.2006.10.016
- Atack JR. Anxioselective compounds acting at the GABA(A) receptor benzodiazepine binding site. Curr Drug Targets CNS Neurol Disord. 2003;2(4):213–32. doi: https://doi.org/10.2174/1568007033482841
- Lie JD, Tu KN, Shen DD, Wong BM. Pharmacological treatment of insomnia. PT. 2015;40(11):759–71.
- Roth T, Drake C. Evolution of insomnia: current status and future direction. Sleep Med. 2004;5(Suppl. 1):S23–30. doi: https://doi.org/10.1016/S1389-9457(04)90004-4
- Gupta P, Sharma U, Schulz TC, Sherrer ES, McLean AB, Robins AJ, West LM. Bioactive diterpenoid containing a reversible “spring-loaded” (E,Z)-dieneone Michael acceptor. Org Lett. 2011;13(15):3920–23. doi: https://doi.org/10.1021/ol201443k
- Li YX, Wijesekara I, Li Y, Kim SK. Phlorotannins as bioactive agents from brown algae. Process Biochem. 2011;46(12):2219–24. doi: https://doi.org/10.1016/j.procbio.2011.09.015
- Cho S, Yang H, Jeon YJ, Lee CJ, Jin YH, Baek NI, et al. Phlorotannins of the edible brown seaweed Ecklonia cava Kjellman induce sleep via positive allosteric modulation of gamma-aminobutyric acid type A-benzodiazepine receptor: A novel neurological activity of seaweed polyphenols. Food Chem. 2012;132(3):1133–42. doi: https://doi.org/10.1016/j.foodchem.2011.08.040
- Cho S, Yoon M, Pae AN, Jin YH, Cho NC, Takata Y, et al. Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABA(A) receptor. Psychopharmacology. 2014;231(14):2825–37. doi: https://doi.org/10.1007/s00213-014-3445-1
- Um MY, Kim JY, Han JK, Kim J, Yang H, Yoon M, et al. Phlorotannin supplement decreases wake after sleep onset in adults with self-reported sleep disturbance: A randomized, controlled, double-blind clinical and polysomnographic study. Phytother Res. 2018;32(4):698–704. doi: https://doi.org/10.1002/ptr.6019
- Yoon M, Kim JS, Jo J, Han D, Cho S. Sleep-Promoting effect of Ecklonia cava: ethanol extract Promotes Non-rapid Eye movement sleep in C57BL/6N mice. Fish Aquat Sci. 2014;17(1):19–25.
- Woo J, Kwon SK, Nam J, Choi S, Takahashi H, Krueger D, et al. The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development. J Cell Biol. 2013;201(6):929–44. doi: https://doi.org/10.1083/jcb.201209132
- Soderhielm PC, Balle T, Bak-Nyhus S, Zhang M, Hansen KM, Ahring PK, Jensen AA. Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors. Biochem Pharmacol. 2018;158:339–58.
- Yang H, Woo J, Pae AN, Um MY, Cho NC, Park KD, et al. Alpha-Pinene, a Major Constituent of Pine Tree Oils, enhances Non-rapid Eye movement sleep in mice through GABAA-benzodiazepine receptors. Mol Pharmacol. 2016;90(5):530–39. doi: https://doi.org/10.1124/mol.116.105080
- Arbilla S, Depoortere H, George P, Langer SZ. Pharmacological profile of the imidazopyridine zolpidem at benzodiazepine receptors and electrocorticogram in rats. Naunyn Schmiedebergs Arch Pharmacol. 1985;330(3):248–51. doi: https://doi.org/10.1007/BF00572441
- Has AT C, Absalom N, van Nieuwenhuijzen PS, Clarkson AN, Ahring PK, Chebib M. Zolpidem is a potent stoichiometry-selective modulator of alpha1beta3 GABAA receptors: evidence of a novel benzodiazepine site in the alpha1-alpha1 interface. Sci Rep. 2016;6:28674. doi: https://doi.org/10.1038/srep28674
- Berezhnoy D, Gravielle MC, Downing S, Kostakis E, Basile AS, Skolnick P, et al. Pharmacological properties of DOV 315,090, an ocinaplon metabolite. BMC Pharmacol. 2008;8(11). doi:10.1186/1471-2210-8-11.
- Fitzgerald AC, Wright BT, Heldt SA. The behavioral pharmacology of zolpidem: evidence for the functional significance of alpha1-containing GABA(A) receptors. Psychopharmacology (Berl). 2014;231(9):1865–96. doi: https://doi.org/10.1007/s00213-014-3457-x
- Spurny R, Ramerstorfer J, Price K, Brams M, Ernst M, Nury H, et al. Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines. Proc Natl Acad Sci USA. 2012;109(44):E3028–34. doi: https://doi.org/10.1073/pnas.1208208109
- McKernan RM, Wafford K, Quirk K, Hadingham KL, Harley EA, Ragan CI, Whiting PJ. The pharmacology of the benzodiazepine site of the GABA-A receptor is dependent on the type of gamma-subunit present. J Recept Signal Transduct Res. 1995;15(1–4):173–83. doi: https://doi.org/10.3109/10799899509045215
- Drexler B, Zinser S, Hentschke H, Antkowiak B. Diazepam decreases action potential firing of neocortical neurons via two distinct mechanisms. Anesth Analg. 2010;111(6):1394–99. doi: https://doi.org/10.1213/ANE.0b013e3181f9c035
- Pandit S, Jo JY, Lee SU, Lee YJ, Lee SY, Ryu PD, et al. Enhanced astroglial GABA uptake attenuates tonic GABAA inhibition of the presympathetic hypothalamic paraventricular nucleus neurons in heart failure. J Neurophysiol. 2015;114(2):914–26. doi: https://doi.org/10.1152/jn.00080.2015
- Pritchett DB, Seeburg PH. Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology. J Neurochem. 1990;54(5):1802–804. doi: https://doi.org/10.1111/j.1471-4159.1990.tb01237.x
- Smith AJ, Alder L, Silk J, Adkins C, Fletcher AE, Scales T, et al. Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux. Mol Pharmacol. 2001;59(5):1108–18. doi: https://doi.org/10.1124/mol.59.5.1108
- Smith TA. Type A gamma-aminobutyric acid (GABAA) receptor subunits and benzodiazepine binding: significance to clinical syndromes and their treatment. Br J Biomed Sci. 2001;58(2):111–21.
- Manandhar B, Paudel P, Seong SH, Jung HA, Choi JS. Characterizing eckol as a therapeutic Aid: A systematic review. Mar Drugs. 2019;17(6):361. doi:10.3390/md17060361.