References
- Kesse-Guyot E, Andreeva VA, Jeandel C, Ferry M, Hercberg S, Galan P. A healthy dietary pattern at midlife is associated with subsequent cognitive performance. J Nutr. 2012;142(5):909–15. doi: https://doi.org/10.3945/jn.111.156257
- Bell L, Lamport DJ, Butler LT, Williams CM. A review of the cognitive effects observed in humans following acute supplementation with flavonoids, and their associated mechanisms of action. Nutrients. 2015;7(12):10290–306. doi: https://doi.org/10.3390/nu7125538
- Lamport DJ, Dye L, Wightman JD, Lawton CL. The effects of flavonoid and other polyphenol consumption on cognitive performance: a systematic research review of human experimental and epidemiological studies. Nutr Aging. 2012;1(1):5–25. doi: https://doi.org/10.3233/NUA-2012-0002
- Garrido J, Borges F. Wine and grape polyphenols—A chemical perspective. Food Res Int. 2013;54(2):1844–58. doi: https://doi.org/10.1016/j.foodres.2013.08.002
- Nassiri-Asl M, Hosseinzadeh H. Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds. Phytotherapy Res. 2009;23(9):1197–204. doi: https://doi.org/10.1002/ptr.2761
- Dal-Pan A, Dudonne S, Bourassa P, Bourdoulous M, Tremblay C, Desjardins Y, et al. Cognitive-enhancing effects of a polyphenols-rich extract from fruits without changes in neuropathology in an animal model of Alzheimer’s disease. J Alzheimer’s Dis. 2017;55(1):115–35. doi: https://doi.org/10.3233/JAD-160281
- Sarkaki A, Farbood Y, Badavi M. The effect of grape seed extract (GSE) on spatial memory in aged male rats. Pak J Med Sci. 2007;23(4):561.
- Shukitt-Hale B, Carey A, Simon L, Mark DA, Joseph JA. Effects of Concord grape juice on cognitive and motor deficits in aging. Nutrition. 2006;22(3):295–302. doi: https://doi.org/10.1016/j.nut.2005.07.016
- Rendeiro C, Rhodes JS, Spencer JP. The mechanisms of action of flavonoids in the brain: direct versus indirect effects. Neurochem Int. 2015;89:126–39. doi: https://doi.org/10.1016/j.neuint.2015.08.002
- Trevizol L, Bassôa L, Fraga I, Munhoz I, Pochmann D, Dani C, et al. Grape juice consumption and/or exercise training-induced neuroplasticity and memory improvement in healthy elderly women.
- Lamport DJ, Lawton CL, Merat N, Jamson H, Myrissa K, Hofman D, et al. Concord grape juice, cognitive function, and driving performance: a 12-wk, placebo-controlled, randomized crossover trial in mothers of preteen children. Am J Clin Nutr. 2016;103(3):775–83. doi: https://doi.org/10.3945/ajcn.115.114553
- Krikorian R, Boespflug EL, Fleck DE, Stein AL, Wightman JD, Shidler MD, et al. Concord grape juice supplementation and neurocognitive function in human aging. J Agric Food Chem. 2012;60(23):5736–42. doi: https://doi.org/10.1021/jf300277g
- Krikorian R, Nash TA, Shidler MD, Shukitt-Hale B, Joseph JA. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr. 2010;103(5):730–4. doi: https://doi.org/10.1017/S0007114509992364
- Haskell-Ramsay C, Stuart R, Okello E, Watson A. Cognitive and mood improvements following acute supplementation with purple grape juice in healthy young adults. Eur J Nutr. 2017;56(8):2621–31. doi: https://doi.org/10.1007/s00394-017-1454-7
- Shi J, Yu J, Pohorly JE, Kakuda Y. Polyphenolics in grape seeds—biochemistry and functionality. J Med Food. 2003;6(4):291–9. doi: https://doi.org/10.1089/109662003772519831
- Tabachnick BG, Fidell LS. Using multivariate statistics. 6th ed Boston (MA): Pearson; 2013.
- Alharbi MH, Lamport DJ, Dodd GF, Saunders C, Harkness L, Butler LT, et al. Flavonoid-rich orange juice is associated with acute improvements in cognitive function in healthy middle-aged males. Eur J Nutr. 2016;55(6):2021–9. doi: https://doi.org/10.1007/s00394-015-1016-9
- Kennedy DO, Wightman EL, Reay JL, Lietz G, Okello EJ, Wilde A, et al. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Am J Clin Nutr. 2010;91(6):1590–7. doi: https://doi.org/10.3945/ajcn.2009.28641
- Wightman EL, Haskell CF, Forster JS, Veasey RC, Kennedy DO. Epigallocatechin gallate, cerebral blood flow parameters, cognitive performance and mood in healthy humans: a double-blind, placebo-controlled, crossover investigation. Human Psychopharmacol. 2012;27(2):177–86. doi: https://doi.org/10.1002/hup.1263
- Hendrickson S J, Mattes R D. No acute effects of grape juice on appetite, implicit memory and mood. Food Nutr Res. 2008;52(1):1891. doi: https://doi.org/10.3402/fnr.v52i0.1891
- Lee J, Torosyan N, Silverman DH. Examining the impact of grape consumption on brain metabolism and cognitive function in patients with mild decline in cognition: a double-blinded placebo controlled pilot study. Exp Gerontol. 2017;87:121–8. doi: https://doi.org/10.1016/j.exger.2016.10.004
- Calapai G, Bonina F, Bonina A, Rizza L, Mannucci C, Arcoraci V, et al. A Randomized, double-blinded, clinical trial on effects of a Vitis vinifera extract on cognitive function in healthy older adults. Front Pharmacol. 2017;8(776.
- Welch RW, Antoine J-M, Berta J-L, Bub A, de Vries J, Guarner F, et al. Guidelines for the design, conduct and reporting of human intervention studies to evaluate the health benefits of foods. Br J Nutr. 2011;106(S2):S3–S15. doi: https://doi.org/10.1017/S0007114511003606
- Sorkin BC, Kuszak AJ, Williamson JS, Hopp DC, Betz JM. The challenge of reproducibility and accuracy in nutrition research: resources and pitfalls. Adv Nutr. 2016;7(2):383–9. doi: https://doi.org/10.3945/an.115.010595
- Zhao D, Simon JE, Wu Q. A critical review on grape polyphenols for neuroprotection: strategies to enhance bioefficacy. Crit Rev Food Sci Nutr. 2019: 1–29. doi: https://doi.org/10.1080/10408398.2018.1546668
- Rodriguez-Mateos A, Rendeiro C, Bergillos-Meca T, Tabatabaee S, George TW, Heiss C, et al. Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. Am J Clin Nutr. 2013;98(5):1179–91. doi: https://doi.org/10.3945/ajcn.113.066639
- Chen TY, Ferruzzi MG, Wu QL, Simon JE, Talcott ST, Wang J, et al. Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat. Mol Nutr Food Res. 2017;61(10):1700111. doi: https://doi.org/10.1002/mnfr.201700111
- Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ. Structure and function of the blood–brain barrier. Neurobiol Dis. 2010;37(1):13–25. doi: https://doi.org/10.1016/j.nbd.2009.07.030
- Margalef M, Pons Z, Iglesias-Carres L, Quiñones M, Bravo FI, Arola-Arnal A, et al. Rat health status affects bioavailability, target tissue levels, and bioactivity of grape seed flavanols. Mol Nutr Food Res. 2017;61(2):1600342. doi: https://doi.org/10.1002/mnfr.201600342