References
- Ogden CL, Carroll MD, Flegal KM. Prevalence of obesity in the United States. JAMA. 2014;312(2):189–90. doi: https://doi.org/10.1001/jama.2014.6228
- Freeman LR, Haley-Zitlin V, Rosenberger DS, Granholm AC. Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms. Nutr. Neurosci. 2014;17(6):241–51. doi: https://doi.org/10.1179/1476830513Y.0000000092
- Malnick SD, Knobler H. The medical complications of obesity. QJM. 2006;99(9):565–79. doi: https://doi.org/10.1093/qjmed/hcl085
- Bullo M, Casas-Agustench P, Amigo-Correig P, Aranceta J, Salas-Salvado J. Inflammation, obesity and comorbidities: the role of diet. Public Health Nutr. 2007;10(10A):1164–72. doi: https://doi.org/10.1017/S1368980007000663
- Myles IA. Fast food fever: reviewing the impacts of the Western diet on immunity. Nutr. J. 2014;13:61. doi: https://doi.org/10.1186/1475-2891-13-61
- Haslam DW, James WP. Obesity. Lancet. 2005;366(9492):1197–209. doi: https://doi.org/10.1016/S0140-6736(05)67483-1
- Singh-Manoux A, Dugravot A, Shipley M, Brunner EJ, Elbaz A, Sabia S, et al. Obesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II study. Alzheimers Dement. 2018;14(2):178–86. doi: https://doi.org/10.1016/j.jalz.2017.06.2637
- Odegaard JI, Chawla A. Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science. 2013;339(6116):172–7. doi: https://doi.org/10.1126/science.1230721
- Monteiro R, Azevedo I. Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm. 2010;2010, 1–10. doi: https://doi.org/10.1155/2010/289645
- Cryan JF, O'Riordan KJ, Cowan CSM, Sandhu KV, Bastiaanssen TFS, Boehme M, et al. The microbiota-gut-brain axis. Physiol. Rev. 2019;99(4):1877–2013. doi: https://doi.org/10.1152/physrev.00018.2018
- Cryan JF, de Wit H. The gut microbiome in psychopharmacology and psychiatry. Psychopharmacology (Berl). 2019;236(5):1407–9. doi: https://doi.org/10.1007/s00213-019-05288-y
- Ley RE. Obesity and the human microbiome. Curr. Opin. Gastroenterol. 2010;26(1):5–11. doi: https://doi.org/10.1097/MOG.0b013e328333d751
- Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56(7):1761–72. doi: https://doi.org/10.2337/db06-1491
- Borre YE, Moloney RD, Clarke G, Dinan TG, Cryan JF. The impact of microbiota on brain and behavior: mechanisms & therapeutic potential. Adv. Exp. Med. Biol. 2014;817:373–403. doi: https://doi.org/10.1007/978-1-4939-0897-4_17
- Desbonnet L, Clarke G, Shanahan F, Dinan TG, Cryan JF. Microbiota is essential for social development in the mouse. Mol. Psychiatry. 2014;19(2):146–8. doi: https://doi.org/10.1038/mp.2013.65
- Chander AM, Yadav H, Jain S, Bhadada SK, Dhawan DK. Cross-talk between gluten, intestinal microbiota and intestinal Mucosa in celiac disease: Recent advances and basis of autoimmunity. Front. Microbiol. 2018;9:2597. doi: https://doi.org/10.3389/fmicb.2018.02597
- Vatanen T, Franzosa EA, Schwager R, Tripathi S, Arthur TD, Vehik K, et al. The human gut microbiome in early-onset type 1 diabetes from the TEDDY study. Nature. 2018;562(7728):589–94. doi: https://doi.org/10.1038/s41586-018-0620-2
- Aydin O, Nieuwdorp M, Gerdes V. The gut microbiome as a target for the treatment of type 2 diabetes. Curr. Diab. Rep. 2018;18(8):55. doi: https://doi.org/10.1007/s11892-018-1020-6
- Yang Y, Smith Jr. DL, Keating KD, Allison DB, Nagy TR. Variations in body weight, food intake and body composition after long-term high-fat diet feeding in C57BL/6J mice. Obesity (Silver Spring). 2014;22(10):2147–55. doi: https://doi.org/10.1002/oby.20811
- Dorfman MD, Krull JE, Douglass JD, Fasnacht R, Lara-Lince F, Meek TH, et al. Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice. Nat. Commun. 2017;8:14556. doi: https://doi.org/10.1038/ncomms14556
- Lainez NM, Jonak CR, Nair MG, Ethell IM, Wilson EH, Carson MJ, et al. Diet-induced obesity elicits macrophage infiltration and reduction in spine density in the hypothalami of male but not female mice. Front. Immunol. 2018;9:1992. doi: https://doi.org/10.3389/fimmu.2018.01992
- Hwang LL, Wang CH, Li TL, Chang SD, Lin LC, Chen CP, et al. Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice. Obesity (Silver Spring. 2010;18(3):463–9. doi: https://doi.org/10.1038/oby.2009.273
- Pettersson US, Walden TB, Carlsson PO, Jansson L, Phillipson M. Female mice are protected against high-fat diet induced metabolic syndrome and increase the regulatory T cell population in adipose tissue. PLoS One. 2012;7(9):e46057. doi: https://doi.org/10.1371/journal.pone.0046057
- Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444(7122):1027–31. doi: https://doi.org/10.1038/nature05414
- Cancello R, Clement K. Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. BJOG. 2006;113(10):1141–7. doi: https://doi.org/10.1111/j.1471-0528.2006.01004.x
- Morrison H, Young K, Qureshi M, Rowe RK, Lifshitz J. Quantitative microglia analyses reveal diverse morphologic responses in the rat cortex after diffuse brain injury. Sci. Rep. 2017;7(1):13211. doi: https://doi.org/10.1038/s41598-017-13581-z
- Young K, Morrison H. Quantifying microglia morphology from photomicrographs of immunohistochemistry prepared tissue using ImageJ. J. Vis. Exp. 2018;136:57648.
- Ali S, Liu X, Queen NJ, Patel RS, Wilkins RK, Mo X, et al. Long-term environmental enrichment affects microglial morphology in middle age mice. Aging (Albany NY). 2019;11(8):2388–402. doi: https://doi.org/10.18632/aging.101923
- Dowd SE, Sun Y, Secor PR, Rhoads DD, Wolcott BM, James GA, et al. Survey of bacterial diversity in chronic wounds using pyrosequencing, DGGE, and full ribosome shotgun sequencing. BMC Microbiol. 2008;8:43. doi: https://doi.org/10.1186/1471-2180-8-43
- Swanson KS, Dowd SE, Suchodolski JS, Middelbos IS, Vester BM, Barry KA, et al. Phylogenetic and gene-centric metagenomics of the canine intestinal microbiome reveals similarities with humans and mice. ISME J. 2011;5(4):639–49. doi: https://doi.org/10.1038/ismej.2010.162
- Dowd SE, Callaway TR, Wolcott RD, Sun Y, McKeehan T, Hagevoort RG, et al. Evaluation of the bacterial diversity in the feces of cattle using 16S rDNA bacterial tag-encoded FLX amplicon pyrosequencing (bTEFAP). BMC Microbiol. 2008;8:125. doi: https://doi.org/10.1186/1471-2180-8-125
- Eren AM, Zozaya M, Taylor CM, Dowd SE, Martin DH, Ferris MJ. Exploring the diversity of Gardnerella vaginalis in the genitourinary tract microbiota of monogamous couples through subtle nucleotide variation. PLoS One. 2011;6(10):e26732. doi: https://doi.org/10.1371/journal.pone.0026732
- Morris EK, Caruso T, Buscot F, Fischer M, Hancock C, Maier TS, et al. Choosing and using diversity indices: insights for ecological applications from the German Biodiversity Exploratories. Ecol. Evol. 2014;4(18):3514–24. doi: https://doi.org/10.1002/ece3.1155
- Dubbelaar ML, Kracht L, Eggen BJL, Boddeke E. The kaleidoscope of microglial phenotypes. Front. Immunol. 2018;9:1753. doi: https://doi.org/10.3389/fimmu.2018.01753
- Van der Heyden JA, Zethof TJ, Olivier B. Stress-induced hyperthermia in singly housed mice. Physiol. Behav. 1997;62(3):463–70. doi: https://doi.org/10.1016/S0031-9384(97)00157-1
- Kulesskaya N, Rauvala H, Voikar V. Evaluation of social and physical enrichment in modulation of behavioural phenotype in C57BL/6J female mice. PLoS One. 2011;6(9):e24755. doi: https://doi.org/10.1371/journal.pone.0024755
- Voikar V, Polus A, Vasar E, Rauvala H. Long-term individual housing in C57BL/6J and DBA/2 mice: assessment of behavioral consequences. Genes Brain Behav. 2005;4(4):240–52. doi: https://doi.org/10.1111/j.1601-183X.2004.00106.x
- Robertson KL, Rowland NE. Effect of two types of environmental enrichment for singly housed mice on food intake and weight gain. Lab Anim. (NY). 2005;34(9):29–32. doi: https://doi.org/10.1038/laban1005-29
- Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proc Natl Acad Sci USA. 2005;102(31):11070–5. doi: https://doi.org/10.1073/pnas.0504978102
- Deshpande NG, Saxena J, Pesaresi TG, Carrell CD, Ashby GB, Liao MK, et al. High fat diet alters gut microbiota but not spatial working memory in early middle-aged sprague dawley rats. PLoS One. 2019;14(5):e0217553. doi: https://doi.org/10.1371/journal.pone.0217553
- Wagner BD, Grunwald GK, Zerbe GO, Mikulich-Gilbertson SK, Robertson CE, Zemanick ET, et al. On the use of diversity measures in longitudinal sequencing studies of microbial communities. Front Microbiol. 2018;9:1037. doi: https://doi.org/10.3389/fmicb.2018.01037
- Schaab M, Kratzsch J. The soluble leptin receptor. Best Pract. Res. Clin. Endocrinol. Metab. 2015;29(5):661–70. doi: https://doi.org/10.1016/j.beem.2015.08.002
- Lihn AS, Pedersen SB, Richelsen B. Adiponectin: action, regulation and association to insulin sensitivity. Obes. Rev. 2005;6(1):13–21. doi: https://doi.org/10.1111/j.1467-789X.2005.00159.x
- Sobesky JL, Barrientos RM, De May HS, Thompson BM, Weber MD, Watkins LR, et al. High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1beta, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism. Brain Behav. Immun. 2014;42:22–32. doi: https://doi.org/10.1016/j.bbi.2014.06.017
- Gzielo K, Kielbinski M, Ploszaj J, Janeczko K, Gazdzinski SP, Setkowicz Z. Long-term consumption of high-fat diet in rats: effects on microglial and astrocytic morphology and neuronal nitric oxide synthase expression. Cell. Mol. Neurobiol. 2017;37(5):783–9. doi: https://doi.org/10.1007/s10571-016-0417-5
- Wu Y, Wu T, Wu J, Zhao L, Li Q, Varghese Z, et al. Chronic inflammation exacerbates glucose metabolism disorders in C57BL/6J mice fed with high-fat diet. J. Endocrinol. 2013;219(3):195–204. doi: https://doi.org/10.1530/JOE-13-0160
- Koss WA, Frick KM. Sex differences in hippocampal function. J. Neurosci. Res. 2017;95(1-2):539–62. doi: https://doi.org/10.1002/jnr.23864
- Underwood EL, Thompson LT. High-fat diet impairs spatial memory and hippocampal intrinsic excitability and sex-dependently alters circulating insulin and hippocampal insulin sensitivity. Biol. Sex Differ. 2016;7:9. doi: https://doi.org/10.1186/s13293-016-0060-3
- Wang DD, Bordey A. The astrocyte odyssey. Prog. Neurobiol. 2008;86(4):342–67.
- Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, et al. Obesity is associated with hypothalamic injury in rodents and humans. J. Clin. Invest. 2012;122(1):153–62. doi: https://doi.org/10.1172/JCI59660
- Lee D, Thaler JP, Berkseth KE, Melhorn SJ, Schwartz MW, Schur EA. Longer T(2) relaxation time is a marker of hypothalamic gliosis in mice with diet-induced obesity. Am J. Physiol. Endocrinol. Metab. 2013;304(11):E1245–50. doi: https://doi.org/10.1152/ajpendo.00020.2013
- De Souza CT, Araujo EP, Bordin S, Ashimine R, Zollner RL, Boschero AC, et al. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology. 2005;146(10):4192–9. doi: https://doi.org/10.1210/en.2004-1520
- Morselli E, Fuente-Martin E, Finan B, Kim M, Frank A, Garcia-Caceres C, et al. Hypothalamic PGC-1alpha protects against high-fat diet exposure by regulating ERalpha. Cell Rep. 2014;9(2):633–45. doi: https://doi.org/10.1016/j.celrep.2014.09.025
- Cavaliere G, Trinchese G, Penna E, Cimmino F, Pirozzi C, Lama A, et al. High-fat diet induces neuroinflammation and mitochondrial impairment in mice cerebral cortex and synaptic fraction. Front. Cell. Neurosci. 2019;13:509. doi: https://doi.org/10.3389/fncel.2019.00509