References
- McFarland HF, Martin R. Multiple sclerosis: a complicated picture of autoimmunity. Nat Immunol. 2007;8:913–19. doi: https://doi.org/10.1038/ni1507
- Leray E, Moreau T, Fromont A, Edan G. Epidemiology of multiple sclerosis. Rev Neurol (Paris). 2016;172:3–13. doi: https://doi.org/10.1016/j.neurol.2015.10.006
- Lassmann H, Van Horssen J, Mahad D. Progressive multiple sclerosis: pathology and pathogenesis. Nature Reviews Neurology. 2012;8:647–56. doi: https://doi.org/10.1038/nrneurol.2012.168
- Turner AP, Alschuler KN. Anxiety is more important than depression in MS–No. Mult Scler J. 2018;24:442–44. doi: https://doi.org/10.1177/1352458517748477
- Patten SB, Marrie RA, Carta MG. Depression in multiple sclerosis. Int Rev Psychiatry. 2017;29:463–72. doi: https://doi.org/10.1080/09540261.2017.1322555
- Théaudin M, Romero K, Feinstein A. In multiple sclerosis anxiety, not depression, is related to gender. Mult Scler J. 2016;22:239–44. doi: https://doi.org/10.1177/1352458515588582
- Fisk JD, Morehouse SA, Brown MG, Skedgel C, Murray TJ. Hospital-based psychiatric service utilization and morbidity in multiple sclerosis. Can J Neurol Sci. 1998;25:230–35. doi: https://doi.org/10.1017/S0317167100034065
- Pandya R, Metz L, Patten SB. Predictive value of the CES-D in detecting depression among candidates for disease-modifying multiple sclerosis treatment. Psychosomatics. 2005;46:131–34. doi: https://doi.org/10.1176/appi.psy.46.2.131
- Solaro C, Trabucco E, Signori A, Martinelli V, Radaelli M, Centonze D, et al. Depressive symptoms correlate with disability and disease course in multiple sclerosis patients: an Italian multi-center study using the Beck depression inventory. PloS one. 2016;11:e0160261. doi: https://doi.org/10.1371/journal.pone.0160261
- Hurley LL, Tizabi Y. Neuroinflammation, neurodegeneration, and depression. Neurotox Res. 2013;23:131–44. doi: https://doi.org/10.1007/s12640-012-9348-1
- Calabrese F, Rossetti AC, Racagni G, Gass P, Riva MA, Molteni R. Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity. Front Cell Neurosci. 2014;8:430. doi: https://doi.org/10.3389/fncel.2014.00430
- Martino M, Rocchi G, Escelsior A, Contini P, Colicchio S, de Berardis D, et al. NGF serum levels variations in major depressed patients receiving duloxetine. Psychoneuroendocrinology. 2013;38:1824–828. doi: https://doi.org/10.1016/j.psyneuen.2013.02.009
- Wang Y, Liu H, Du X-D, Zhang Y, Yin G, Zhang B-S, et al. Association of low serum BDNF with depression in patients with Parkinson's disease. Parkinsonism Relat Disord. 2017;41:73–78. doi: https://doi.org/10.1016/j.parkreldis.2017.05.012
- Mondal AC, Fatima M. Direct and indirect evidences of BDNF and NGF as key modulators in depression: role of antidepressants treatment. Int J Neurosci. 2019;129:283–96. doi: https://doi.org/10.1080/00207454.2018.1527328
- Tanis KQ, Newton SS, Duman RS. Targeting neurotrophic/growth factor expression and signaling for antidepressant drug development. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders). 2007;6:151–60.
- Yaffe K, Lindquist K, Penninx B, Simonsick E, Pahor M, Kritchevsky S, et al. Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology. 2003;61:76–80. doi: https://doi.org/10.1212/01.WNL.0000073620.42047.D7
- Cantarel BL, Waubant E, Chehoud C, Kuczynski J, DeSantis TZ, Warrington J, et al. Gut microbiota in multiple sclerosis: possible influence of immunomodulators. J Invest Med. 2015;63:729–34. doi: https://doi.org/10.1097/JIM.0000000000000192
- Berer K, Gerdes LA, Cekanaviciute E, Jia X, Xiao L, Xia Z, et al. Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A. 2017;114:10719–24. doi: https://doi.org/10.1073/pnas.1711233114
- Fleming J, Fabry Z. The hygiene hypothesis and multiple sclerosis. Annals Neurol: Off J Am Neurol Assoc Child Neurol Soc. 2007;61:85–89. doi: https://doi.org/10.1002/ana.21092
- Rook GA. Hygiene hypothesis and autoimmune diseases. Clin Rev Allergy Immunol. 2012;42:5–15. doi: https://doi.org/10.1007/s12016-011-8285-8
- García-Ródenas CL, Bergonzelli GE, Nutten S, Schumann A, Cherbut C, Turini M, et al. Nutritional approach to restore impaired intestinal barrier function and growth after neonatal stress in rats. J Pediatr Gastroenterol Nutr. 2006;43:16–24. doi: https://doi.org/10.1097/01.mpg.0000226376.95623.9f
- O'Mahony SM, Marchesi JR, Scully P, Codling C, Ceolho A-M, Quigley EM, et al. Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses. Biol Psychiatry. 2009;65:263–67. doi: https://doi.org/10.1016/j.biopsych.2008.06.026
- Gareau MG, Wine E, Rodrigues DM, Cho JH, Whary MT, Philpott DJ, et al. Bacterial infection causes stress-induced memory dysfunction in mice. Gut. 2011;60:307–17. doi: https://doi.org/10.1136/gut.2009.202515
- Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet–induced obesity and diabetes in mice. Diabetes. 2008;57:1470–81. doi: https://doi.org/10.2337/db07-1403
- Sanders ME. Probiotics: definition, sources, selection, and uses. Clin Infect Dis. 2008;46:S58–61. doi: https://doi.org/10.1086/523341
- Kennedy RJ, Kirk SJ, Gardiner KR. Probiotics (Br J Surg 2001; 88: 161-2). Br J Surg. 2001;88:1018–19. doi: https://doi.org/10.1046/j.1365-2168.2001.01850-12.x
- Michail S, Sylvester F, Fuchs G, Issenman R. Clinical efficacy of probiotics: review of the evidence with focus on children. J Pediatr Gastroenterol Nutr. 2006;43:550–57. doi: https://doi.org/10.1097/00005176-200610000-00036
- Aureli P, Capurso L, Castellazzi AM, Clerici M, Giovannini M, Morelli L, et al. Probiotics and health: an evidence-based review. Pharmacol Res. 2011;63:366–76. doi: https://doi.org/10.1016/j.phrs.2011.02.006
- Chen J, Chia N, Kalari KR, Yao JZ, Novotna M, Soldan MMP, et al. Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. Sci Rep. 2016;6:28484. doi: https://doi.org/10.1038/srep28484
- Kechagia M, Basoulis D, Konstantopoulou S, Dimitriadi D, Gyftopoulou K, Skarmoutsou N, et al. Health benefits of probiotics: a review. ISRN Nutr. 2013;9:2013.
- Ashraf R, Shah NP. Immune system stimulation by probiotic microorganisms. Crit Rev Food Sci Nutr. 2014;54:938–56. doi: https://doi.org/10.1080/10408398.2011.619671
- Mazloom Z, Yousefinejad A, Dabbaghmanesh MH. Effect of probiotics on lipid profile, glycemic control, insulin action, oxidative stress, and inflammatory markers in patients with type 2 diabetes: a clinical trial. Iran J Med Sci. 2013;38:387–394.
- Saxelin M, Tynkkynen S, Mattila-Sandholm T, de Vos WM. Probiotic and other functional microbes: from markets to mechanisms. Curr Opin Biotechnol. 2005;16:204–11. doi: https://doi.org/10.1016/j.copbio.2005.02.003
- Umbrello G, Esposito S. Microbiota and neurologic diseases: potential effects of probiotics. J Transl Med. 2016;14:298. doi: https://doi.org/10.1186/s12967-016-1058-7
- Du Toit A. The gut microbiome and mental health. London: Nature Publishing Group; 2019.
- Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, Kappos L, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald criteria”. Anna Neurol: Off J Am Neurol Assoc Child Neurol Soc. 2005;58:840–46. doi: https://doi.org/10.1002/ana.20703
- Goldberg DP, Hillier VF. A scaled version of the general health questionnaire. Psychol Med. 1979;9:139–45. doi: https://doi.org/10.1017/S0033291700021644
- Ghassemzadeh H, Mojtabai R, Karamghadiri N, Ebrahimkhani N. Psychometric properties of a Persian-language version of the Beck depression Inventory–second edition: BDI-II-PERSIAN. Depress Anxiety. 2005;21:185–92. doi: https://doi.org/10.1002/da.20070
- Wang YP, Gorenstein C. Psychometric properties of the Beck depression Inventory-II: a comprehensive review. Braz J Psychiatry. 2013;35:416–31. doi: https://doi.org/10.1590/1516-4446-2012-1048
- Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale: application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol. 1989;46:1121–23. doi: https://doi.org/10.1001/archneur.1989.00520460115022
- Melzack R. The McGill pain questionnaire: major properties and scoring methods. Pain. 1975;1:277–99. doi: https://doi.org/10.1016/0304-3959(75)90044-5
- Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMC Med. 2010;8:18. doi: https://doi.org/10.1186/1741-7015-8-18
- Boeschoten RE, Braamse AM, Beekman AT, Cuijpers P, van Oppen P, Dekker J, Uitdehaag BM. Prevalence of depression and anxiety in multiple sclerosis: a systematic review and meta-analysis. J Neurol Sci. 2017;372:331–41. doi: https://doi.org/10.1016/j.jns.2016.11.067
- Jiang H, Ling Z, Zhang Y, Mao H, Ma Z, Yin Y, et al. Altered fecal microbiota composition in patients with major depressive disorder. Brain Behav Immun. 2015;48:186–94. doi: https://doi.org/10.1016/j.bbi.2015.03.016
- Huang W, Gan W, Huang A, Fu Y, Shang Y, Chen Y, et al. Efficacy of electroacupuncture combined with probiotics for depression and chronic diarrhea in patients and effect on serum inflammatory cytokines, NE and BDNF. Exp Ther Med. 2019;18:3470–74.
- Moludi J, Alizadeh M, Mohammadzad MHS, Davari M. The effect of probiotics supplementation on depressive symptoms and quality of life in patients after Myocardial Infarction: results of a Preliminary double blind clinical trial. Psychosom Med. 2019.
- Akkasheh G, Kashani-Poor Z, Tajabadi-Ebrahimi M, Jafari P, Akbari H, Taghizadeh M, et al. Clinical and metabolic response to probiotic administration in patients with major depressive disorder: a randomized, double-blind, placebo-controlled trial. Nutrition. 2016;32:315–20. doi: https://doi.org/10.1016/j.nut.2015.09.003
- Frota ERC, Rodrigues DH, Donadi EA, Brum DG, Maciel DRK, Teixeira AL. Increased plasma levels of brain derived neurotrophic factor (BDNF) after multiple sclerosis relapse. Neurosci Lett. 2009;460:130–32. doi: https://doi.org/10.1016/j.neulet.2009.05.057
- Wens I, Keytsman C, Deckx N, Cools N, Dalgas U, Eijnde BO. Brain derived neurotrophic factor in multiple sclerosis: effect of 24 weeks endurance and resistance training. Eur J Neurol. 2016;23:1028–35. doi: https://doi.org/10.1111/ene.12976
- Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroentero. 2015;28:203.
- Evrensel A, Ceylan ME. The gut-brain axis: the missing link in depression. Clin Psychopharmacol Neurosci. 2015;13:239. doi: https://doi.org/10.9758/cpn.2015.13.3.239
- Foster JA, Neufeld K-AM. Gut–brain axis: how the microbiome influences anxiety and depression. Trends Neurosci. 2013;36:305–12. doi: https://doi.org/10.1016/j.tins.2013.01.005
- Kerschensteiner M, Gallmeier E, Behrens L, Leal VV, Misgeld T, Klinkert WE, et al. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med. 1999;189:865–70. doi: https://doi.org/10.1084/jem.189.5.865
- Khan MS, Wu GWY, Reus VI, Hough CM, Lindqvist D, Westrin A, et al. Low serum brain-derived neurotrophic factor is associated with suicidal ideation in major depressive disorder. Psychiatry Res. 2019;273:108–13. doi: https://doi.org/10.1016/j.psychres.2019.01.013
- Haghighat N, Rajabi S, Mohammadshahi M. Effect of synbiotic and probiotic supplementation on serum brain-derived neurotrophic factor level, depression and anxiety symptoms in hemodialysis patients: a randomized, double-blinded, clinical trial. Nutr Neurosci. 2019;9:1–10.
- Ranuh R, Athiyyah AF, Darma A, Risky VP, Riawan W, Surono IS, Sudarmo SM. Effect of the probiotic Lactobacillus plantarum IS-10506 on BDNF and 5HT stimulation: role of intestinal microbiota on the gut-brain axis. Iran J Microbiol. 2019;11:145–50.
- Hwang YH, Park S, Paik JW, Chae SW, Kim DH, Jeong DG, et al. Efficacy and safety of Lactobacillus plantarum C29-fermented soybean (DW2009) in individuals with mild cognitive impairment: A 12-week, multi-Center, randomized, double-blind, placebo-controlled clinical trial. Nutrients. 2019;11:305–312. doi: https://doi.org/10.3390/nu11020305
- Islas-Hernandez A, Aguilar-Talamantes HS, Bertado-Cortes B, Mejia-delCastillo GJ, Carrera-Pineda R, Cuevas-Garcia CF, Garcia-delaTorre P. BDNF and Tau as biomarkers of severity in multiple sclerosis. Biomark Med. 2018;12:717–26. doi: https://doi.org/10.2217/bmm-2017-0374
- Stadelmann C, Kerschensteiner M, Misgeld T, BruÈck W, Hohlfeld R, Lassmann H. BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells? Brain. 2002;125:75–85. doi: https://doi.org/10.1093/brain/awf015
- Nibuya M, Morinobu S, Duman RS. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci. 1995;15:7539–47. doi: https://doi.org/10.1523/JNEUROSCI.15-11-07539.1995
- Wiener CD, de Mello Ferreira S, Moreira FP, Bittencourt G, de Oliveira JF, Molina ML, et al. Serum levels of nerve growth factor (NGF) in patients with major depression disorder and suicide risk. J Affect Disord. 2015;184:245–48. doi: https://doi.org/10.1016/j.jad.2015.05.067
- Diniz BS, Teixeira AL, Machado-Vieira R, Talib LL, Gattaz WF, Forlenza OV. Reduced serum nerve growth factor in patients with late-life depression. Am J Geriatr Psychiatry. 2013;21:493–96. doi: https://doi.org/10.1016/j.jagp.2013.01.014
- Nockher WA, Renz H. Neurotrophins in clinical diagnostics: pathophysiology and laboratory investigation. Clin Chim Acta. 2005;352:49–74. doi: https://doi.org/10.1016/j.cccn.2004.10.002
- Ng QX, Peters C, Ho CYX, Lim DY, Yeo W-S. A meta-analysis of the use of probiotics to alleviate depressive symptoms. J Affect Disord. 2018;228:13–19. doi: https://doi.org/10.1016/j.jad.2017.11.063
- Savignac H, Kiely B, Dinan T, Cryan J. B ifidobacteria exert strain-specific effects on stress-related behavior and physiology in BALB/c mice. Neurogastroent Motil. 2014;26:1615–27. doi: https://doi.org/10.1111/nmo.12427
- Dallanora S, de Souza YM, Deon RG, Tracey CA, Freitas-Vilela AA, Roesch LFW, Mendes RH. Do probiotics effectively ameliorate glycemic control during gestational diabetes? A systematic review. Arch Gynecol Obstet. 2018;298:477–85. doi: https://doi.org/10.1007/s00404-018-4809-2
- Ait-Belgnaoui A, Colom A, Braniste V, Ramalho L, Marrot A, Cartier C, et al. Probiotic gut effect prevents the chronic psychological stress-induced brain activity abnormality in mice. Neurogastroent Moti. 2014;26:510–20. doi: https://doi.org/10.1111/nmo.12295
- Desbonnet L, Garrett L, Clarke G, Bienenstock J, Dinan TG. The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat. J Psychiatr Res. 2008;43:164–74. doi: https://doi.org/10.1016/j.jpsychires.2008.03.009
- Liang S, Wu X, Hu X, Wang T, Jin F. Recognizing depression from the microbiota–gut–brain axis. Int J Mol Sci. 2018;19:1592. doi: https://doi.org/10.3390/ijms19061592
- Schmidt C. Mental health: thinking from the gut. Nature. 2015;518:S12–15. doi: https://doi.org/10.1038/518S13a
- Steenbergen L, Sellaro R, van Hemert S, Bosch JA, Colzato LS. A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. Brain Behav Immun. 2015;48:258–64. doi: https://doi.org/10.1016/j.bbi.2015.04.003
- Aghamohammadi D, Ayromlou H, Dolatkhah N, Jahanjoo F, Shakouri SK. The effects of probiotic Saccharomyces boulardii on the mental health, quality of life, fatigue, pain, and indices of inflammation and oxidative stress in patients with multiple sclerosis: study protocol for a double-blind randomized controlled clinical trial. Trials. 2019;20:379. doi: https://doi.org/10.1186/s13063-019-3454-9
- Singh P, Chopra K, Kuhad A, Kaur I. Role of Lactobacillus acidophilus loaded floating beads in chronic fatigue syndrome: behavioral and biochemical evidences. Neurogastroent Motil. 2012;24:366–e170. doi: https://doi.org/10.1111/j.1365-2982.2011.01861.x
- Benson C, Kerr BJ. Pain and cognition in multiple sclerosis. Behavioral Neurobiology of chronic pain. New York City: Springer; 2014. p. 201–15.
- Shadnoush M, Hosseini RS, Mehrabi Y, Delpisheh A, Alipoor E, Faghfoori Z, et al. Probiotic yogurt affects pro-and anti-inflammatory factors in patients with inflammatory bowel disease. Iranian J Pharmaceutical Res. 2013;12:929.
- Hemarajata P, Versalovic J. Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation. Therap Adv Gastroenterol. 2013;6:39–51. doi: https://doi.org/10.1177/1756283X12459294
- Wingenfeld K, Wolf OT. HPA axis alterations in mental disorders: impact on memory and its relevance for therapeutic interventions. CNS Neurosci Ther. 2011;17:714–22. doi: https://doi.org/10.1111/j.1755-5949.2010.00207.x
- Vinolo MA, Rodrigues HG, Nachbar RT, Curi R. Regulation of inflammation by short chain fatty acids. Nutrients. 2011;3:858–76. doi: https://doi.org/10.3390/nu3100858