Evaluation of modulatory effects of saffron (Crocus sativus L.) aqueous extract on oxidative stress in ischemic stroke patients: a randomized clinical trial

References

• Zitnanova I, Siarnik P, Kollar B, Chomova M, Pazderova P, Andrezalova L, et al. Oxidative stress markers and their dynamic changes in patients after acute ischemic stroke. Oxid Med Cell Longev. 2016;2016, 9761697.
   PubMed Web of Science ®Google Scholar
• Pirzad Jahromi G, Shabanzadeh Pirsaraei A, Sadr SS, Kaka G, Jafari M, Seidi S, et al. Multipotent bone marrow stromal cell therapy promotes endogenous cell proliferation following ischemic stroke. Clin Exp Pharmacol Physiol. 2015;42(11):1158–67.
   PubMed Web of Science ®Google Scholar
• Valavi M, Zarban A, Firuzabadi MD, Sharifzadeh G, Zarezade M. Oxidative stress and antioxidant markers in serum and red blood cell of patients with ischemic and hemorrhagic stroke: a case-control study. Mod Care J. 2016;13(3):e10340.
   Google Scholar
• Icme F, Erel O, Avci A, Satar S, Gulen M, Acehan S. The relation between oxidative stress parameters, ischemic stroke, and hemorrhagic stroke. Turk J Med Sci. 2015;45(4):947–53.
   PubMed Web of Science ®Google Scholar
• Chehaibi K, Trabelsi I, Mahdouani K, Slimane MN. Correlation of oxidative stress parameters and inflammatory markers in ischemic stroke patients. J Stroke Cerebrovasc Dis. 2016;25(11):2585–93.
   PubMed Web of Science ®Google Scholar
• Milanlioglu A, Aslan M, Ozkol H, Çilingir V, Aydın MN, Karadas S. Serum antioxidant enzymes activities and oxidative stress levels in patients with acute ischemic stroke: influence on neurological status and outcome. Wien Klin Wochenschr. 2016;128(5-6):169–74.
   PubMed Web of Science ®Google Scholar
• Niizuma K, Yoshioka H, Chen H, Kim GS, Jung JE, Katsu M, et al. Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia. Biochim Biophys Acta. 2010;1802(1):92–9.
   PubMed Web of Science ®Google Scholar
• Shirley R, Ord E, Work L. Oxidative stress and the use of antioxidants in stroke. Antioxidants. 2014;3(3):472–501.
   Google Scholar
• Rodrigo R, Fernandez-Gajardo R, Gutierrez R, Manuel Matamala J, Carrasco R, Miranda-Merchak A, et al. Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities. CNS Neurol Disord Drug Targets. 2013;12(5):698–714.
   PubMed Web of Science ®Google Scholar
• Farkhondeh T, Samarghandian S. The effect of saffron (Crocus sativus L.) and its ingredients on the management of diabetes mellitus and dislipidemia. Afr J Pharm Pharmacol. 2014;8(20):541–9.
   Google Scholar
• Hasanpour M, Ashrafi M, Erjaee H, Nazifi S. The effect of saffron aqueous extract on oxidative stress parameters and important biochemical enzymes in the testis of streptozotocin-induced diabetic rats. Physiol Pharmacol. 2018;22(1):28–37.
   Web of Science ®Google Scholar
• Javadi B, Sahebkar A, Emami SA. A survey on saffron in major islamic traditional medicine books. Iran J Basic Med Sci. 2013;16(1):1–11.
   PubMed Web of Science ®Google Scholar
• Khazdair MR, Boskabady MH, Hosseini M, Rezaee R, Tsatsakis AM. The effects of Crocus sativus (saffron) and its constituents on nervous system: a review. Avicenna J Phytomed. 2015;5(5):376–91.
   PubMed Web of Science ®Google Scholar
• Mousavi SZ, Bathaie SZ. Historical uses of saffron: identifying potential new avenues for modern research. Avicenna J Phytomed. 2011;1(2):57–66.
   Google Scholar
• Basiri-Moghadam M, Hamzei A, Moslem A-R, Pasban-Noghabi S, Ghorbani N, Ghenaati J. Comparison of the anxiolytic effects of saffron (Crocus sativus. L) and diazepam before herniorrhaphy surgery: a double blind randomized clinical trial. Zahedan J Res Med Sci. 2016;18(3):e6248.
   Google Scholar
• Lahmass I, Ouahhoud S, Elyoubi M, Benabbas R, Sabouni A, Asehraou A, et al. Evaluation of antioxidant activities of saffron stigma and spath as by-product of Crocus sativus L. MOJ Biol Med. 2018;3(4):29.
   Google Scholar
• Vakili A, Einali MR, Bandegi AR. Protective effect of crocin against cerebral ischemia in a dose-dependent manner in a rat model of ischemic stroke. J Stroke Cerebrovasc Dis. 2014;23(1):106–13.
   PubMed Web of Science ®Google Scholar
• Samarghandian S, Azimi-Nezhad M, Samini F, Farkhondeh T. The role of saffron in attenuating age-related oxidative damage in rat hippocampus. Recent Pat Food Nutr Agric. 2017;8(3):183–9.
   PubMedGoogle Scholar
• Hosseinzadeh H, Sadeghnia HR. Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus. J Pharm Pharm Sci. 2005;8(3):394–9.
   PubMed Web of Science ®Google Scholar
• Hosseinzadeh H, Modaghegh MH, Saffari Z. Crocus sativus L.(saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle. Evid Based Complement Alternat Med. 2009;6(3):343–50.
   PubMed Web of Science ®Google Scholar
• Mollazadeh H, Emami SA, Hosseinzadeh H. Razi’s Al-Hawi and saffron (Crocus sativus): a review. Iran J Basic Med Sci. 2015;18(12):1153–66.
   PubMed Web of Science ®Google Scholar
• Asadollahi M, Nikdokht P, Hatef B, Sadr SS, Sahraei H, Assarzadegan F, et al. Protective properties of the aqueous extract of saffron (Crocus sativus L.) in ischemic stroke, randomized clinical trial. J Ethnopharmacol. 2019;238, 111833.
   PubMed Web of Science ®Google Scholar
• Jafari M, Salehi M, Ahmadi S, Asgari A, Abasnezhad M, Hajigholamali M. The role of oxidative stress in diazinon-induced tissues toxicity in Wistar and Norway rats. Toxicol Mech Methods. 2012;22:638–47.
   PubMed Web of Science ®Google Scholar
• Yoshino F, Yoshida A, Umigai N, Kubo K, Masaichi C-i. Crocetin reduces the oxidative stress induced reactive oxygen species in the stroke-prone spontaneously hypertensive rats (SHRSPs) brain. J Clin Biochem Nutr. 2011;49(3):182–7.
   PubMed Web of Science ®Google Scholar
• Vani JR, Mohammadi MT, Foroshani MS, Jafari M. Polyhydroxylated fullerene nanoparticles attenuate brain infarction and oxidative stress in rat model of ischemic stroke. EXCLI J. 2016;15:378–90.
   PubMed Web of Science ®Google Scholar
• Jahanbakhsh Z, Rasoulian B, Jafari M, Shekarforoush S, Esmailidehaj M, taghi Mohammadi M, et al. Protective effect of crocin against reperfusion-induced cardiac arrhythmias in anaesthetized rats. EXCLI J. 2012;11:20–9.
   PubMed Web of Science ®Google Scholar
• Cojocaru IM, Cojocaru M, Sapira V, Ionescu A. Evaluation of oxidative stress in patients with acute ischemic stroke. Romanian J Inter Med. 2013;51(2):97–106.
   PubMedGoogle Scholar
• Cherubini A, Polidori MC, Bregnocchi M, Pezzuto S, Cecchetti R, Ingegni T, et al. Antioxidant profile and early outcome in stroke patients. Stroke. 2000;31(10):2295–300.
   PubMed Web of Science ®Google Scholar
• Al-khalifa AW, Maatook MA, Jewad AM. Lipid profile and oxidative stress status in cerebrovascular accident patients. Int J Adv Res. 2003;6:443–7.
   Google Scholar
• Zimmermann C, Winnefeld K, Streck S, Roskos M, Haberl R. Antioxidant status in acute stroke patients and patients at stroke risk. Eur Neurol. 2004;51(3):157–61.
   PubMed Web of Science ®Google Scholar
• Ochiai T, Shimeno H, Mishima K-i, Iwasaki K, Fujiwara M, Tanaka H, et al. Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Biochim Biophys Acta. 2007;1770(4):578–84.
   PubMed Web of Science ®Google Scholar
• Saleem S, Ahmad M, Ahmad AS, Yousuf S, Ansari MA, Khan MB, et al. Effect of saffron (Crocus sativus) on neurobehavioral and neurochemical changes in cerebral ischemia in rats. J Medicinal Food. 2006;9(2):246–53.
   PubMed Web of Science ®Google Scholar
• Jafari M, Salehi M, Asgari A, Ahmadi S, Abbasnezhad M, Hajihoosani R, et al. Effects of paraoxon on serum biochemical parameters and oxidative stress induction in various tissues of Wistar and Norway rats. Environ Toxicol Pharmacol. 2012;34(3):876–87.
   PubMed Web of Science ®Google Scholar
• Khazaie S, Jafari M, Heydari J, Asgari A, Tahmasebi K, Salehi M, et al. Modulatory effects of vitamin C on biochemical and oxidative changes induced by acute exposure to diazinon in rat various tissues: prophylactic and therapeutic roles. J Anim Physiol Anim Nutr (Berl). 2019;103(5):1619–28.
   PubMed Web of Science ®Google Scholar
• Ozkul A, Akyol A, Yenisey C, Arpaci E, Kiylioglu N, Tataroglu C. Oxidative stress in acute ischemic stroke. J Clin Neurosci. 2007;14(11):1062–6.
   PubMed Web of Science ®Google Scholar
• Mohammad R, Daryoush M, Ali R, Yousef D, Mehrdad N. Attenuation of oxidative stress of hepatic tissue by ethanolic extract of saffron (dried stigmas of Crocus sativus L.) in streptozotocin (STZ)-induced diabetic rats. Afr J Pharm Pharmacol. 2011;5(19):2166–73.
   Google Scholar
• Mousavi SR, Jafari M, Rezaei S, Agha-alinejad H, Sobhani V. Evaluation of the effects of different intensities of forced running wheel exercise on oxidative stress biomarkers in muscle, liver and serum of untrained rats. Lab Anim (NY). 2020;49(4):119–25.
   PubMed Web of Science ®Google Scholar
• Gariballa S, Hutchin T, Sinclair A. Antioxidant capacity after acute ischaemic stroke. Q J Med. 2002;95(10):685–90.
   Google Scholar
• Hariri AT, Moallem SA, Mahmoudi M, Hosseinzadeh H. The effect of crocin and safranal, constituents of saffron, against subacute effect of diazinon on hematological and genotoxicity indices in rats. Phytomedicine. 2011;18(6):499–504.
   PubMed Web of Science ®Google Scholar
• Zare-Mirzaie A, Kazeminezhad B, Ghouchani MA. The correlation between serum Vitamin D level and total antioxidant capacity in diabetic and non-diabetic subjects in Iran. Iran J Pathol. 2018;13(2):212–9.
   PubMedGoogle Scholar
• Rostampour F, Ghasemi H, Habibollah M-b, Ranjbar A, Heidary Shayesteh T, Tayebinia H. Total antioxidant capacity, lipid peroxidation, thiol group and catalase activity in patients with kidney stone. Avicenna J Med Biochem. 2017;5(2):60–4.
   Google Scholar
• Ullegaddi R, Powers H, Gariballa S. Antioxidant supplementation enhances antioxidant capacity and mitigates oxidative damage following acute ischaemic stroke. Eur J Clin Nutr. 2005;59(12):1367–73.
   PubMed Web of Science ®Google Scholar
• Razavi M, Hosseinzadeh H, Abnous K, Motamedshariaty VS, Imenshahidi M. Crocin restores hypotensive effect of subchronic administration of diazinon in rats. Iran J Basic Med Sci. 2013;16(1):64.
   PubMed Web of Science ®Google Scholar
• Poma A, Fontecchio G, Carlucci G, Chichiricco G. Anti-inflammatory properties of drugs from saffron crocus. Antiinflamm Antiallergy Agents Med Chem. 2012;11(1):37–51.
   PubMedGoogle Scholar
• Soeda S, Ochiai T, Paopong L, Tanaka H, Shoyama Y, Shimeno H. Crocin suppresses tumor necrosis factor-α-induced cell death of neuronally differentiated PC-12 cells. Life sci. 2001;69(24):2887–98.
   PubMed Web of Science ®Google Scholar