Publication Cover
Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 26, 2023 - Issue 4
265
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Dietary experience with glucose and fructose fosters heightened avidity for glucose-containing sugars independent of TRPM5 taste transduction in mice

, , &

References

  • Lapis TJ, Penner MH, Lim J. Evidence that humans can taste glucose polymers. Chem Senses. 2014;39:737–47.
  • Lapis TJ, Penner MH, Lim J. Humans can taste glucose oligomers independent of the ht1r2/ht1r3 sweet taste receptor. Chem Senses. 2016;41:755–62.
  • Low JYQ, Lacy KE, McBride RL, Keast RSJ. Evidence supporting oral sensitivity to complex carbohydrates independent of sweet taste sensitivity in humans. PLoS One. 2017;12:e0188784.
  • Nissenbaum JW, Sclafani A. Qualitative differences in polysaccharide and sugar tastes in the rat: a two-carbohydrate taste model. Neurosci Biobehav Rev. 1987;11:187–96.
  • Pullicin AJ, Penner MH, Lim J. Human taste detection of glucose oligomers with low degree of polymerization. PLoS One. 2017;12:e0183008.
  • Sclafani A, Mann S. Carbohydrate taste preferences in rats: glucose, sucrose, maltose, fructose and polycose compared. Physiol Behav. 1987;40:563–8.
  • Smith KR, Spector AC. Detection of maltodextrin and its discrimination from sucrose are independent of the t1r2 + t1r3 heterodimer. Am J Physiol Regul Integr Comp Physiol. 2017;313:R450–62.
  • Treesukosol Y, Spector AC. Orosensory detection of sucrose, maltose, and glucose is severely impaired in mice lacking t1r2 or t1r3, but polycose sensitivity remains relatively normal. Am J Physiol Regul Integr Comp Physiol. 2012;303:R218–35.
  • Zukerman S, Glendinning JI, Margolskee RF, Sclafani A. T1r3 taste receptor is critical for sucrose but not polycose taste. Am J Physiol Regul Integr Comp Physiol. 2009;296:R866–76.
  • Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS. A novel family of mammalian taste receptors. Cell. 2000;100:693–702.
  • Bachmanov AA, Li X, Reed DR, Ohmen JD, Li S, Chen Z, et al. Positional cloning of the mouse saccharin preference (sac) locus. Chem Senses. 2001;26:925–33.
  • Dotson CD, Spector AC. Behavioral discrimination between sucrose and other natural sweeteners in mice: implications for the neural coding of t1r ligands. J Neurosci. 2007;27:11242–53.
  • Hoon MA, Adler E, Lindemeier J, Battey JF, Ryba NJ, Zuker CS. Putative mammalian taste receptors: a class of taste-specific gpcrs with distinct topographic selectivity. Cell. 1999;96:541–51.
  • Kitagawa M, Kusakabe Y, Miura H, Ninomiya Y, Hino A. Molecular genetic identification of a candidate receptor gene for sweet taste. Biochem Biophys Res Commun. 2001;283:236–42.
  • Max M, Shanker YG, Huang L, Rong M, Liu Z, Campagne F, et al. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus sac. Nat Genet. 2001;28:58–63.
  • Montmayeur JP, Liberles SD, Matsunami H, Buck LB. A candidate taste receptor gene near a sweet taste locus. Nat Neurosci. 2001;4:492–8.
  • Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, Zuker CS. Mammalian sweet taste receptors. Cell. 2001;106:381–90.
  • Zhao GQ, Zhang Y, Hoon MA, Chandrashekar J, Erlenbach I, Ryba NJ, Zuker CS. The receptors for mammalian sweet and umami taste. Cell. 2003;115:255–66.
  • Breslin PAS, Izumi A, Tharp A, Ohkuri T, Yokoo Y, Flammer LJ, et al. Evidence that human oral glucose detection involves a sweet taste pathway and a glucose transporter pathway. PLoS One. 2021;16:e0256989.
  • Damak S, Rong M, Yasumatsu K, Kokrashvili Z, Varadarajan V, Zou S, et al. Detection of sweet and umami taste in the absence of taste receptor t1r3. Science. 2003;301:850–3.
  • Eylam S, Kennedy LM. Identification and characterization of human fructose or glucose taste variants with hypogeusia for one monosaccharide but not for the other. Ann N Y Acad Sci. 1998;855:170–4.
  • Ohkuri T, Yasumatsu K, Horio N, Jyotaki M, Margolskee RF, Ninomiya Y. Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity. Am J Physiol Regul Integr Comp Physiol. 2009;296:R960–71.
  • Schier LA, Inui-Yamamoto C, Blonde GD, Spector AC. T1r2+t1r3-independent chemosensory inputs contributing to behavioral discrimination of sugars in mice. Am J Physiol Regul Integr Comp Physiol. 2019;316:R448–62.
  • Schier LA, Spector AC. Behavioral evidence for more than one taste signaling pathway for sugars in rats. J Neurosci. 2016;36:113–24.
  • Spector AC, Grill HJ. Differences in the taste quality of maltose and sucrose in rats: issues involving the generalization of conditioned taste aversions. Chem Senses. 1988;13:95–113.
  • Spector AC, Markison S, St John SJ, Garcea M. Sucrose vs. maltose taste discrimination by rats depends on the input of the seventh cranial nerve. Am J Physiol. 1997;272:R1210–8.
  • Toyono T, Seta Y, Kataoka S, Oda M, Toyoshima K. Differential expression of the glucose transporters in mouse gustatory papillae. Cell Tissue Res. 2011;345:243–52.
  • Yasumatsu K, Ohkuri T, Yoshida R, Iwata S, Margolskee RF, Ninomiya Y. Sodium-glucose cotransporter 1 as a sugar taste sensor in mouse tongue. Acta Physiol. 2020;230:e13529.
  • Sclafani A, Zukerman S, Ackroff K. Residual glucose taste in t1r3 knockout but not trpm5 knockout mice. Physiol Behav. 2020;222:112945.
  • Spector AC, Schier LA. Behavioral evidence that select carbohydrate stimuli activate t1r-independent receptor mechanisms. Appetite. 2018;122:26–31.
  • Liman ER. Trpm5 and taste transduction. Handb Exp Pharmacol. 2007;179:287–98.
  • de Araujo IE. Circuit organization of sugar reinforcement. Physiol Behav. 2016;164:473–7.
  • Glendinning JI, Frim YG, Hochman A, Lubitz GS, Basile AJ, Sclafani A. Glucose elicits cephalic-phase insulin release in mice by activating katp channels in taste cells. Am J Physiol Regul Integr Comp Physiol. 2017;312:R597–610.
  • Glendinning JI, Stano S, Holter M, Azenkot T, Goldman O, Margolskee RF, et al. Sugar-induced cephalic-phase insulin release is mediated by a t1r2+t1r3-independent taste transduction pathway in mice. Am J Physiol Regul Integr Comp Physiol. 2015;309:R552–60.
  • Glendinning JI, Maleh J, Ortiz G, Touzani K, Sclafani A. Olfaction contributes to the learned avidity for glucose relative to fructose in mice. Am J Physiol Regul Integr Comp Physiol. 2020;318:R901–16.
  • Sukumaran SK, Yee KK, Iwata S, Kotha R, Quezada-Calvillo R, Nichols BL, et al. Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides. Proc Natl Acad Sci USA. 2016;113:6035–40.
  • Yee KK, Sukumaran SK, Kotha R, Gilbertson TA, Margolskee RF. Glucose transporters and atp-gated k+ (katp) metabolic sensors are present in type 1 taste receptor 3 (t1r3)-expressing taste cells. Proc Natl Acad Sci USA. 2011;108:5431–6.
  • Breslin PAS, Beauchamp GK, Pugh EN. Monogeusia for fructose, glucose, sucrose, and maltose. Percept Psychophys. 1996;58:327–41.
  • Treesukosol Y, Blonde GD, Spector AC. T1r2 and t1r3 subunits are individually unnecessary for normal affective licking responses to polycose: implications for saccharide taste receptors in mice. Am J Physiol Regul Integr Comp Physiol. 2009;296:R855–65.
  • Sako N, Shimura T, Komure M, Mochizuki R, Matsuo R, Yamamoto T. Differences in taste responses to polycose and common sugars in the rat as revealed by behavioral and electrophysiological studies. Physiol Behav. 1994;56:741–5.
  • Treesukosol Y, Smith KR, Spector AC. Behavioral evidence for a glucose polymer taste receptor that is independent of the t1r2+3 heterodimer in a mouse model. J Neurosci. 2011;31:13527–34.
  • Sclafani A, Zukerman S, Glendinning JI, Margolskee RF. Fat and carbohydrate preferences in mice: the contribution of alpha-gustducin and trpm5 taste-signaling proteins. Am J Physiol Regul Integr Comp Physiol. 2007;293:R1504–13.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.