The role of nutrition on Parkinson’s disease: a systematic review

References

• Hirtz D, Thurman DJ, Gwinn-Hardy K, Mohamed M, Chaudhuri AR, Zalutsky R. How common are the “common” neurologic disorders? Neurology. 2007;68(5):326–337.
   PubMed Web of Science ®Google Scholar
• Dickson DW. Neuropathology of Parkinson disease. Parkinsonism Relat Disord. 2018;46(Suppl 1):S30–S33.
   PubMed Web of Science ®Google Scholar
• Willis AW, Sterling C, Racette BA. Conjugal Parkinsonism and Parkinson disease: a case series with environmental risk factor analysis. Parkinsonism Relat Disord. 2010;16(3):163–166.
   PubMed Web of Science ®Google Scholar
• Klingelhoefer L, Reichmann H. The Gut and nonmotor symptoms in Parkinson's disease. Int Rev Neurobiol. 2017;134:787–809.
   PubMed Web of Science ®Google Scholar
• Kalia LV, Lang AE. Parkinson's disease. Lancet. 2015;386(9996):896–912.
   PubMed Web of Science ®Google Scholar
• Erro R, Stamelou M. The motor syndrome of Parkinson's disease. Int Rev Neurobiol. 2017;132:25–32.
   PubMed Web of Science ®Google Scholar
• Ascherio A, Schwarzschild MA. The epidemiology of Parkinson's disease: risk factors and prevention. Lancet Neurol. 2016;15(12):1257–1272.
   PubMed Web of Science ®Google Scholar
• Postuma RB, Gagnon JF, Montplaisir J. Rapid eye movement sleep behavior disorder as a biomarker for neurodegeneration: the past 10 years. Sleep Med. 2013;14(8):763–767.
   PubMed Web of Science ®Google Scholar
• Berg D, Postuma RB, Adler CH, Bloem BR, Chan P, Dubois B, et al. MDS research criteria for prodromal Parkinson's disease. Mov Disord. 2015;30(12):1600–1611.
   PubMed Web of Science ®Google Scholar
• Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, et al. MDS clinical diagnostic criteria for Parkinson's disease. Mov Disord. 2015;30(12):1591–1601.
   PubMed Web of Science ®Google Scholar
• Billingsley KJ, Bandres-Ciga S, Saez-Atienzar S, Singleton AB. Genetic risk factors in Parkinson's disease. Cell Tissue Res. 2018;373(1):9–20.
   PubMed Web of Science ®Google Scholar
• Lill CM. Genetics of Parkinson's disease. Mol Cell Probes. 2016;30(6):386–396.
   PubMed Web of Science ®Google Scholar
• Miller DB, O'Callaghan JP. Biomarkers of Parkinson's disease: present and future. Metabolism. 2015;64(3 Suppl 1):S40–46.
   PubMed Web of Science ®Google Scholar
• Gasser T. Genomic and proteomic biomarkers for Parkinson disease. Neurology. 2009;72(7 Suppl):S27–31.
   PubMedGoogle Scholar
• Tanner CM, Ottman R, Goldman SM, Ellenberg J, Chan P, Mayeux R, Langston JW. Parkinson disease in twins: an etiologic study. JAMA. 1999;281(4):341–346.
   PubMed Web of Science ®Google Scholar
• van Heesbeen HJ, Smidt MP. Entanglement of genetics and Epigenetics in Parkinson's disease. Front Neurosci. 2019;13:277.
   PubMed Web of Science ®Google Scholar
• Barichella M, Savardi C, Mauri A, Marczewska A, Vairo A, Baldo C, et al. Diet with LPP for renal patients increases daily energy expenditure and improves motor function in parkinsonian patients with motor fluctuations. Nutr Neurosci. 2007;10(3–4):129–135.
   PubMed Web of Science ®Google Scholar
• Ransohoff RM. How neuroinflammation contributes to neurodegeneration. Science. 2016;353(6301):777–783.
   PubMed Web of Science ®Google Scholar
• Desplats P, Spencer B, Coffee E, Patel P, Michael S, Patrick C, et al. Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases. J Biol Chem. 2011;286(11):9031–9037.
   PubMed Web of Science ®Google Scholar
• van Heesbeen HJ, Mesman S, Veenvliet JV, Smidt MP. Epigenetic mechanisms in the development and maintenance of dopaminergic neurons. Development. 2013;140(6):1159–1169.
   PubMed Web of Science ®Google Scholar
• Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, et al. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell. 2008;135(5):907–918.
   PubMed Web of Science ®Google Scholar
• Jing H, Lin H. Sirtuins in epigenetic regulation. Chem Rev. 2015;115(6):2350–2375.
   PubMed Web of Science ®Google Scholar
• Matsumoto L, Takuma H, Tamaoka A, Kurisaki H, Date H, Tsuji S, Iwata A. Cpg demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease. PLoS One. 2010;5(11):e15522.
   PubMed Web of Science ®Google Scholar
• Fu KA, Paul KC, Lu AT, Horvath S, Keener AM, Bordelon Y, et al. DNA methylation-based surrogates of plasma proteins are associated with Parkinson's disease risk. J Neurol Sci. 2021;431:120046.
   PubMed Web of Science ®Google Scholar
• Mahmoud AM, Ali MM. Methyl donor micronutrients that modify DNA methylation and Cancer outcome. Nutrients. 2019;11:3.
   Web of Science ®Google Scholar
• Ma K, Xiong N, Shen Y, Han C, Liu L, Zhang G, et al. Weight loss and malnutrition in patients with Parkinson's disease: Current knowledge and Future prospects. Front Aging Neurosci. 2018;10:1.
   PubMed Web of Science ®Google Scholar
• Ongun N. Does nutritional status affect Parkinson's disease features and quality of life? PLoS One. 2018;13(10):e0205100.
   PubMed Web of Science ®Google Scholar
• Tian Y, Xu W, Zhang H, Tam KY, Zhang H, Yang L, et al. The scalp time-varying networks of N170: reference, latency, and information flow. Front Neurosci. 2018;12:250.
   PubMed Web of Science ®Google Scholar
• Barichella M, Cereda E, Cassani E, Pinelli G, Iorio L, Ferri V, et al. Dietary habits and neurological features of Parkinson's disease patients: implications for practice. Clin Nutr. 2017;36(4):1054–1061.
   PubMed Web of Science ®Google Scholar
• Minato T, Maeda T, Fujisawa Y, Tsuji H, Nomoto K, Ohno K, Hirayama M. Progression of Parkinson's disease is associated with gut dysbiosis: Two-year follow-up study. PLoS One. 2017;12(11):e0187307.
   PubMed Web of Science ®Google Scholar
• Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009;6(7):e1000100.
   PubMed Web of Science ®Google Scholar
• Chen H, Zhang SM, Hernan MA, Willett WC, Ascherio A. Diet and Parkinson's disease: a potential role of dairy products in men. Ann Neurol. 2002;52(6):793–801.
   PubMed Web of Science ®Google Scholar
• Chen H, Zhang SM, Hernan MA, Willett WC, Ascherio A. Dietary intakes of fat and risk of Parkinson's disease. Am J Epidemiol. 2003;157(11):1007–1014.
   PubMed Web of Science ®Google Scholar
• de Lau LM, Bornebroek M, Witteman JC, Hofman A, Koudstaal PJ, Breteler MM. Dietary fatty acids and the risk of Parkinson disease: the rotterdam study. Neurology. 2005;64(12):2040–2045.
   PubMed Web of Science ®Google Scholar
• Park M, Ross GW, Petrovitch H, White LR, Masaki KH, Nelson JS, et al. Consumption of milk and calcium in midlife and the future risk of Parkinson disease. Neurology. 2005;64(6):1047–1051.
   PubMed Web of Science ®Google Scholar
• Marczewska A, De Notaris R, Sieri S, Barichella M, Fusconi E, Pezzoli G. Protein intake in parkinsonian patients using the EPIC food frequency questionnaire. Mov Disord. 2006;21(8):1229–1231.
   PubMed Web of Science ®Google Scholar
• Chen H, O'Reilly E, McCullough ML, Rodriguez C, Schwarzschild MA, Calle EE, et al. Consumption of dairy products and risk of Parkinson's disease. Am J Epidemiol. 2007;165(9):998–1006.
   PubMed Web of Science ®Google Scholar
• Gao X, Chen H, Fung TT, Logroscino G, Schwarzschild MA, Hu FB, Ascherio A. Prospective study of dietary pattern and risk of Parkinson disease. Am J Clin Nutr. 2007;86(5):1486–1494.
   PubMed Web of Science ®Google Scholar
• Saaksjarvi K, Knekt P, Rissanen H, Laaksonen MA, Reunanen A, Mannisto S. Prospective study of coffee consumption and risk of Parkinson's disease. Eur J Clin Nutr. 2008;62(7):908–915.
   PubMed Web of Science ®Google Scholar
• Powers KM, Smith-Weller T, Franklin GM, Longstreth WT, Jr., Swanson PD, Checkoway H. Dietary fats, cholesterol and iron as risk factors for Parkinson's disease. Parkinsonism Relat Disord. 2009;15(1):47–52.
   PubMed Web of Science ®Google Scholar
• Fukushima W, Miyake Y, Tanaka K, Sasaki S, Kiyohara C, Tsuboi Y, et al. Alcohol drinking and risk of Parkinson's disease: a case-control study in Japan. BMC Neurol. 2010;10:111.
   PubMed Web of Science ®Google Scholar
• Jaafar AF, Gray WK, Porter B, Turnbull EJ, Walker RW. A cross-sectional study of the nutritional status of community-dwelling people with idiopathic Parkinson's disease. BMC Neurol. 2010;10:124.
   PubMed Web of Science ®Google Scholar
• Murakami K, Miyake Y, Sasaki S, Tanaka K, Fukushima W, Kiyohara C, et al. Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease: a case-control study in Japan. Br J Nutr. 2010b;104(5):757–764.
   PubMed Web of Science ®Google Scholar
• Wang G, Wan Y, Cheng Q, Xiao Q, Wang Y, Zhang J, et al. Malnutrition and associated factors in Chinese patients with Parkinson's disease: results from a pilot investigation. Parkinsonism Relat Disord. 2010;16(2):119–123.
   PubMed Web of Science ®Google Scholar
• Alcalay RN, Gu Y, Mejia-Santana H, Cote L, Marder KS, Scarmeas N. The association between Mediterranean diet adherence and Parkinson's disease. Mov Disord. 2012;27(6):771–774.
   PubMed Web of Science ®Google Scholar
• Gao X, Cassidy A, Schwarzschild MA, Rimm EB, Ascherio A. Habitual intake of dietary flavonoids and risk of Parkinson disease. Neurology. 2012;78(15):1138–1145.
   PubMed Web of Science ®Google Scholar
• Okubo H, Miyake Y, Sasaki S, Murakami K, Tanaka K, Fukushima W, et al. Dietary patterns and risk of Parkinson's disease: a case-control study in Japan. Eur J Neurol. 2012;19(5):681–688.
   PubMed Web of Science ®Google Scholar
• Kyrozis A, Ghika A, Stathopoulos P, Vassilopoulos D, Trichopoulos D, Trichopoulou A. Dietary and lifestyle variables in relation to incidence of Parkinson's disease in Greece. Eur J Epidemiol. 2013;28(1):67–77.
   PubMed Web of Science ®Google Scholar
• Liu R, Guo X, Park Y, Wang J, Huang X, Hollenbeck A, et al. Alcohol consumption, types of alcohol, and Parkinson's disease. PLoS One. 2013;8(6):e66452.
   PubMed Web of Science ®Google Scholar
• Saaksjarvi K, Knekt P, Lundqvist A, Mannisto S, Heliovaara M, Rissanen H, Jarvinen R. A cohort study on diet and the risk of Parkinson's disease: the role of food groups and diet quality. Br J Nutr. 2013;109(2):329–337.
   PubMed Web of Science ®Google Scholar
• Sheard JM, Ash S, Mellick GD, Silburn PA, Kerr GK. Malnutrition in a sample of community-dwelling people with Parkinson's disease. PLoS One. 2013;8(1):e53290.
   PubMed Web of Science ®Google Scholar
• Dong J, Beard JD, Umbach DM, Park Y, Huang X, Blair A, et al. Dietary fat intake and risk for Parkinson's disease. Mov Disord. 2014;29(13):1623–1630.
   PubMed Web of Science ®Google Scholar
• Hughes KC, Gao X, Kim IY, Rimm EB, Wang M, Weisskopf MG, et al. Intake of antioxidant vitamins and risk of Parkinson's disease. Mov Disord. 2016;31(12):1909–1914.
   PubMed Web of Science ®Google Scholar
• Tan LC, Methawasin K, Tan EK, Tan JH, Au WL, Yuan JM, Koh WP. Dietary cholesterol, fats and risk of Parkinson's disease in the Singapore Chinese health study. J Neurol Neurosurg Psychiatry. 2016;87(1):86–92.
   PubMed Web of Science ®Google Scholar
• Cassani E, Barichella M, Ferri V, Pinelli G, Iorio L, Bolliri C, et al. Dietary habits in Parkinson's disease: adherence to Mediterranean diet. Parkinsonism Relat Disord. 2017;42:40–46.
   PubMed Web of Science ®Google Scholar
• Hill-Burns EM, Debelius JW, Morton JT, Wissemann WT, Lewis MR, Wallen ZD, et al. Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome. Mov Disord. 2017;32(5):739–749.
   PubMed Web of Science ®Google Scholar
• Hughes KC, Gao X, Kim IY, Wang M, Weisskopf MG, Schwarzschild MA, Ascherio A. Intake of dairy foods and risk of Parkinson disease. Neurology. 2017;89(1):46–52.
   PubMed Web of Science ®Google Scholar
• Mischley LK. Nutrition and nonmotor symptoms of Parkinson's disease. Int Rev Neurobiol. 2017;134:1143–1161.
   PubMed Web of Science ®Google Scholar
• Postuma RB, Anang J, Pelletier A, Joseph L, Moscovich M, Grimes D, et al. Caffeine as symptomatic treatment for Parkinson disease (cafe-PD): A randomized trial. Neurology. 2017;89(17):1795–1803.
   PubMed Web of Science ®Google Scholar
• Yang F, Wolk A, Hakansson N, Pedersen NL, Wirdefeldt K. Dietary antioxidants and risk of Parkinson's disease in two population-based cohorts. Mov Disord. 2017a;32(11):1631–1636.
   PubMed Web of Science ®Google Scholar
• Agarwal P, Wang Y, Buchman AS, Holland TM, Bennett DA, Morris MC. MIND Diet associated with reduced incidence and delayed progression of ParkinsonismA in Old Age. J Nutr Health Aging. 2018;22(10):1211–1215.
   PubMed Web of Science ®Google Scholar
• Phillips MCL, Murtagh DKJ, Gilbertson LJ, Asztely FJS, Lynch CDP. Low-fat versus ketogenic diet in Parkinson's disease: A pilot randomized controlled trial. Mov Disord. 2018;33(8):1306–1314.
   PubMed Web of Science ®Google Scholar
• Budrewicz S, Zmarzly A, Raczka D, Szczepanska A, Koziorowska-Gawron E, Slotwinski K, Koszewicz M. Clinical and nutritional correlations in Parkinson's disease: Preliminary report. Adv Clin Exp Med. 2019;28(2):193–198.
   PubMed Web of Science ®Google Scholar
• Maraki MI, Yannakoulia M, Stamelou M, Stefanis L, Xiromerisiou G, Kosmidis MH, et al. Mediterranean diet adherence is related to reduced probability of prodromal Parkinson's disease. Mov Disord. 2019;34(1):48–57.
   PubMed Web of Science ®Google Scholar
• Paul BS, Singh T, Paul G, Jain D, Singh G, Kaushal S, Chhina RS. Prevalence of malnutrition in Parkinson's disease and correlation with Gastrointestinal symptoms. Ann Indian Acad Neurol. 2019;22(4):447–452.
   PubMed Web of Science ®Google Scholar
• Schirinzi T, Martella G, Imbriani P, Di Lazzaro G, Franco D, Colona VL, et al. Dietary vitamin E as a protective factor for Parkinson's disease: clinical and experimental evidence. Front Neurol. 2019;10:148.
   PubMed Web of Science ®Google Scholar
• Baert F, Matthys C, Mellaerts R, Lemaitre D, Vlaemynck G, Foulon V. Dietary intake of Parkinson's disease patients. Front Nutr. 2020;7:105.
   PubMed Web of Science ®Google Scholar
• Barichella M, Cereda E, Iorio L, Pinelli G, Ferri V, Cassani E, et al. Clinical correlates of serum 25-hydroxyvitamin D in Parkinson's disease. Nutr Neurosci. 2020;26(10):148.
   Web of Science ®Google Scholar
• Gruber MT, Witte OW, Grosskreutz J, Prell T. Association between malnutrition, clinical parameters and health-related quality of life in elderly hospitalized patients with Parkinson's disease: A cross-sectional study. PLoS One. 2020;15(5):e0232764.
   PubMed Web of Science ®Google Scholar
• Hegelmaier T, Lebbing M, Duscha A, Tomaske L, Tonges L, Holm JB, et al. Interventional influence of the intestinal microbiome through Dietary intervention and bowel cleansing might improve motor symptoms in Parkinson's disease. Cells. 2020;9(2):376.
   PubMed Web of Science ®Google Scholar
• Jones JD, Rahmani E, Garcia E, Jacobs JP. Gastrointestinal symptoms are predictive of trajectories of cognitive functioning in de novo Parkinson's disease. Parkinsonism Relat Disord. 2020;72:7–12.
   PubMed Web of Science ®Google Scholar
• Lin TK, Chang YY, Chen NC, Liou CW, Lan MY, Chen YF, Tsai CL. Nutritional status associated with molecular biomarkers, physiological indices, and clinical severity in Parkinson's disease patients. Int J Environ Res Public Health. 2020;17(16).
   Web of Science ®Google Scholar
• Molsberry S, Bjornevik K, Hughes KC, Healy B, Schwarzschild M, Ascherio A. Diet pattern and prodromal features of Parkinson disease. Neurology. 2020;95(15):e2095–e2108.
   PubMed Web of Science ®Google Scholar
• Paknahad Z, Sheklabadi E, Moravejolahkami AR, Chitsaz A, Hassanzadeh A. The effects of Mediterranean diet on severity of disease and serum total antioxidant capacity (TAC) in patients with Parkinson's disease: a single center, randomized controlled trial. Nutr Neurosci. 2020b;(2):313–320.
   Web of Science ®Google Scholar
• Peters S, Gallo V, Vineis P, Middleton LT, Forsgren L, Sacerdote C, et al. Alcohol consumption and risk of Parkinson's disease: data from a large prospective European cohort. Mov Disord. 2020;35(7):1258–1263.
   PubMed Web of Science ®Google Scholar
• Yang T, Zhan Z, Zhang L, Zhu J, Liu Y, Zhang L, et al. Prevalence and risk factors for malnutrition in patients With Parkinson's disease. Front Neurol. 2020;11:533731.
   PubMed Web of Science ®Google Scholar
• Ying AF, Khan S, Wu Y, Jin A, Wong ASY, Tan EK, et al. Dietary antioxidants and risk of Parkinson's disease in the Singapore Chinese health study. Mov Disord. 2020;35(10):1765–1773.
   PubMed Web of Science ®Google Scholar
• Hantikainen E, Trolle Lagerros Y, Ye W, Serafini M, Adami HO, Bellocco R, Bonn S. Dietary antioxidants and the risk of Parkinson disease: The Swedish National March cohort. Neurology. 2021b;96(6):e895–e903.
   PubMed Web of Science ®Google Scholar
• Metcalfe-Roach A, Yu AC, Golz E, Cirstea M, Sundvick K, Kliger D, et al. MIND and Mediterranean diets associated with later onset of Parkinson's disease. Mov Disord. 2021a;36(4):977–984.
   PubMedGoogle Scholar
• Yin W, Lof M, Pedersen NL, Sandin S, Fang F. Mediterranean dietary pattern at middle Age and risk of Parkinson's disease: a Swedish cohort study. Mov Disord. 2021;36(1):255–260.
   PubMed Web of Science ®Google Scholar
• Corridoni D, Pastorelli L, Mattioli B, Locovei S, Ishikawa D, Arseneau KO, et al. Probiotic bacteria regulate intestinal epithelial permeability in experimental ileitis by a TNF-dependent mechanism. PLoS One. 2012;7(7):e42067.
   PubMed Web of Science ®Google Scholar
• Devos D, Cabantchik ZI, Moreau C, Danel V, Mahoney-Sanchez L, Bouchaoui H, et al. Conservative iron chelation for neurodegenerative diseases such as Parkinson's disease and amyotrophic lateral sclerosis. J Neural Transm (Vienna). 2020;127(2):189–203.
   PubMed Web of Science ®Google Scholar
• Huovinen E, Harkanen T, Martelin T, Koskinen S, Aromaa A. Predicting coronary heart disease mortality–assessing uncertainties in population forecasts and death probabilities by using Bayesian inference. Int J Epidemiol. 2006;35(5):1246–1252.
   PubMed Web of Science ®Google Scholar
• Twelves D, Perkins KS, Counsell C. Systematic review of incidence studies of Parkinson's disease. Mov Disord. 2003;18(1):19–31.
   PubMed Web of Science ®Google Scholar
• Kivimaki M, Luukkonen R, Batty GD, Ferrie JE, Pentti J, Nyberg ST, et al. Body mass index and risk of dementia: analysis of individual-level data from 1.3 million individuals. Alzheimers Dement. 2018;14(5):601–609.
   PubMed Web of Science ®Google Scholar
• Faxen-Irving G, Fereshtehnejad SM, Falahati F, Cedergren L, Goranzon H, Wallman K, et al. Body mass index in different dementia disorders: results from the Swedish dementia quality registry (SveDem). Dement Geriatr Cogn Dis Extra. 2014;4(1):65–75.
   PubMedGoogle Scholar
• Jeong SM, Han K, Kim D, Rhee SY, Jang W, Shin DW. Body mass index, diabetes, and the risk of Parkinson's disease. Mov Disord. 2020;35(2):236–244.
   PubMed Web of Science ®Google Scholar
• Lee JJ, Oh JS, Ham JH, Lee DH, Lee I, Sohn YH, et al. Association of body mass index and the depletion of nigrostriatal dopamine in Parkinson's disease. Neurobiol Aging. 2016;38:197–204.
   PubMed Web of Science ®Google Scholar
• Chen H, Zhang SM, Schwarzschild MA, Hernan MA, Willett WC, Ascherio A. Obesity and the risk of Parkinson's disease. Am J Epidemiol. 2004b;159(6):547–555.
   PubMed Web of Science ®Google Scholar
• Noyce AJ, Kia DA, Hemani G, Nicolas A, Price TR, De Pablo-Fernandez E, et al. Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study. PLoS Med. 2017;14(6):e1002314.
   PubMed Web of Science ®Google Scholar
• Mischley LK, Lau RC, Bennett RD. Role of diet and nutritional supplements in Parkinson's disease progression. Oxid Med Cell Longev. 2017;2017:6405278.
   PubMed Web of Science ®Google Scholar
• Paknahad Z, Sheklabadi E, Derakhshan Y, Bagherniya M, Chitsaz A. The effect of the Mediterranean diet on cognitive function in patients with Parkinson's disease: A randomized clinical controlled trial. Complement Ther Med. 2020a;50:102366.
   PubMed Web of Science ®Google Scholar
• Nani A, Murtaza B, Sayed Khan A, Khan NA, Hichami A. Antioxidant and anti-inflammatory potential of polyphenols contained in Mediterranean diet in obesity: molecular mechanisms. Molecules. 2021;26(4):985.
   PubMed Web of Science ®Google Scholar
• Giugliano D, Ceriello A, Esposito K. The effects of diet on inflammation: emphasis on the metabolic syndrome. J Am Coll Cardiol. 2006;48(4):677–685.
   PubMed Web of Science ®Google Scholar
• Hwang O. Role of oxidative stress in Parkinson's disease. Exp Neurobiol. 2013;22(1):11–17.
   PubMedGoogle Scholar
• Manoharan S, Guillemin GJ, Abiramasundari RS, Essa MM, Akbar M, Akbar MD. The role of reactive oxygen species in the pathogenesis of Alzheimer's disease, Parkinson's disease, and huntington's disease: A mini review. Oxid Med Cell Longev. 2016;2016:8590578.
   PubMed Web of Science ®Google Scholar
• Gu Y, Luchsinger JA, Stern Y, Scarmeas N. Mediterranean diet, inflammatory and metabolic biomarkers, and risk of Alzheimer's disease. J Alzheimers Dis. 2010;22(2):483–492.
   PubMed Web of Science ®Google Scholar
• Fontana L, Ghezzi L, Cross AH, Piccio L. Effects of dietary restriction on neuroinflammation in neurodegenerative diseases. J Exp Med. 2021;218(2):e20190086.
   Web of Science ®Google Scholar
• Bailey MA, Holscher HD. Microbiome-Mediated effects of the Mediterranean diet on inflammation. Adv Nutr. 2018;9(3):193–206.
   PubMed Web of Science ®Google Scholar
• Mitjavila MT, Fandos M, Salas-Salvado J, Covas MI, Borrego S, Estruch R, et al. The Mediterranean diet improves the systemic lipid and DNA oxidative damage in metabolic syndrome individuals. A randomized, controlled, trial. Clin Nutr. 2013;32(2):172–178.
   PubMed Web of Science ®Google Scholar
• Ravussin E, Redman LM, Rochon J, Das SK, Fontana L, Kraus WE, et al. A 2-year randomized controlled trial of human caloric restriction: feasibility and effects on predictors of health span and longevity. J Gerontol A Biol Sci Med Sci. 2015;70(9):1097–1104.
   PubMed Web of Science ®Google Scholar
• Bianchi VE, Herrera PF, Laura R. Effect of nutrition on neurodegenerative diseases. A systematic review. Nutr Neurosci. 2019;(10):810–834.
   PubMed Web of Science ®Google Scholar
• Bianchi VE. Caloric restriction in heart failure: a systematic review. Clin Nutr ESPEN. 2020;38:50–60.
   PubMed Web of Science ®Google Scholar
• Madeo F, Carmona-Gutierrez D, Hofer SJ, Kroemer G. Caloric restriction mimetics against Age-associated disease: targets, mechanisms, and therapeutic potential. Cell Metab. 2019;29(3):592–610.
   PubMed Web of Science ®Google Scholar
• Spadaro O, Youm Y, Shchukina I, Ryu S, Sidorov S, Ravussin A, et al. Caloric restriction in humans reveals immunometabolic regulators of health span. Science. 2022;375(6581):671–677.
   PubMed Web of Science ®Google Scholar
• Speakman JR, Mitchell SE. Caloric restriction. Mol Aspects Med. 2011;32(3):159–221.
   PubMed Web of Science ®Google Scholar
• Wheless JW. History of the ketogenic diet. Epilepsia. 2008;49(Suppl 8):3–5.
   PubMedGoogle Scholar
• Koh S, Dupuis N, Auvin S. Ketogenic diet and neuroinflammation. Epilepsy Res. 2020;167:106454.
   PubMed Web of Science ®Google Scholar
• Bostock EC, Kirkby KC, Taylor BV. The current status of the ketogenic Diet in psychiatry. Front Psychiatry. 2017;8:43.
   PubMed Web of Science ®Google Scholar
• Jensen NJ, Wodschow HZ, Nilsson M, Rungby J. Effects of ketone bodies on brain metabolism and function in neurodegenerative diseases. Int J Mol Sci. 2020;21:22.
   Web of Science ®Google Scholar
• Koyuncu H, Fidan V, Toktas H, Binay O, Celik H. Effect of ketogenic diet versus regular diet on voice quality of patients with Parkinson's disease. Acta Neurol Belg. 2020;(6):1729–1732.
   PubMed Web of Science ®Google Scholar
• Wlodarek D. Role of ketogenic diets in neurodegenerative diseases (Alzheimer's disease and Parkinson's disease). Nutrients. 2019;11(1):169.
   PubMed Web of Science ®Google Scholar
• Neveu V, Perez-Jimenez J, Vos F, Crespy V, du Chaffaut L, Mennen L, et al. (2010). Phenol-Explorer: an online comprehensive database on polyphenol contents in foods. Database (Oxford). 2010:bap024.
   Google Scholar
• Kujawska M, Jodynis-Liebert J. Polyphenols in Parkinson's disease: A systematic review of In vivo studies. Nutrients. 2018;10(5):642.
   Web of Science ®Google Scholar
• Shahpiri Z, Bahramsoltani R, Hosein Farzaei M, Farzaei F, Rahimi R. Phytochemicals as future drugs for Parkinson's disease: a comprehensive review. Rev Neurosci. 2016;27(6):651–668.
   PubMed Web of Science ®Google Scholar
• Lou H, Jing X, Wei X, Shi H, Ren D, Zhang X. Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway. Neuropharmacology. 2014;79:380–388.
   PubMed Web of Science ®Google Scholar
• Kim HD, Jeong KH, Jung UJ, Kim SR. Naringin treatment induces neuroprotective effects in a mouse model of Parkinson's disease in vivo, but not enough to restore the lesioned dopaminergic system. J Nutr Biochem. 2016;28:140–146.
   PubMed Web of Science ®Google Scholar
• Antunes MS, Goes AT, Boeira SP, Prigol M, Jesse CR. Protective effect of hesperidin in a model of Parkinson's disease induced by 6-hydroxydopamine in aged mice. Nutrition. 2014;30(11–12):1415–1422.
   PubMed Web of Science ®Google Scholar
• Jung UJ, Kim SR. Beneficial effects of flavonoids against Parkinson's disease. J Med Food. 2018;21(5):421–432.
   PubMed Web of Science ®Google Scholar
• Motawi TK, Sadik NAH, Hamed MA, Ali SA, Khalil WKB, Ahmed YR. Potential therapeutic effects of antagonizing adenosine A2A receptor, curcumin and niacin in rotenone-induced Parkinson's disease mice model. Mol Cell Biochem. 2020;465(1–2):89–102.
   PubMed Web of Science ®Google Scholar
• Dutta D, Mohanakumar KP. Tea and Parkinson's disease: constituents of tea synergize with antiparkinsonian drugs to provide better therapeutic benefits. Neurochem Int. 2015;89:181–190.
   PubMed Web of Science ®Google Scholar
• Chan DK, Mellick GD, Hung WT, Woo J. Genetic and environmental risk factors and their interactions for Parkinson's disease in a Chinese population. J Clin Neurosci. 2003;10(3):313–315.
   PubMed Web of Science ®Google Scholar
• Tan EK, Tan C, Fook-Chong SM, Lum SY, Chai A, Chung H, et al. Dose-dependent protective effect of coffee, tea, and smoking in Parkinson's disease: a study in ethnic Chinese. J Neurol Sci. 2003;216(1):163–167.
   PubMed Web of Science ®Google Scholar
• Tan LC, Koh WP, Yuan JM, Wang R, Au WL, Tan JH, et al. Differential effects of black versus green tea on risk of Parkinson's disease in the Singapore Chinese Health study. Am J Epidemiol. 2008;167(5):553–560.
   PubMed Web of Science ®Google Scholar
• Kandinov B, Giladi N, Korczyn AD. Smoking and tea consumption delay onset of Parkinson's disease. Parkinsonism Relat Disord. 2009;15(1):41–46.
   PubMed Web of Science ®Google Scholar
• Li FJ, Ji HF, Shen L. A meta-analysis of tea drinking and risk of Parkinson's disease. ScientificWorldJournal. 2012;2012:923464.
   PubMedGoogle Scholar
• Ascherio A, Zhang SM, Hernan MA, Kawachi I, Colditz GA, Speizer FE, Willett WC. Prospective study of caffeine consumption and risk of Parkinson's disease in men and women. Ann Neurol. 2001;50(1):56–63.
   PubMed Web of Science ®Google Scholar
• Gao X, Chen H, Choi HK, Curhan G, Schwarzschild MA, Ascherio A. Diet, urate, and Parkinson's disease risk in men. Am J Epidemiol. 2008;167(7):831–838.
   PubMed Web of Science ®Google Scholar
• Li R, Singh M. Sex differences in cognitive impairment and Alzheimer's disease. Front Neuroendocrinol. 2014;35(3):385–403.
   PubMed Web of Science ®Google Scholar
• Jurado-Coronel JC, Cabezas R, Avila Rodriguez MF, Echeverria V, Garcia-Segura LM, Barreto GE. Sex differences in Parkinson's disease: features on clinical symptoms, treatment outcome, sexual hormones and genetics. Front Neuroendocrinol. 2018;50:18–30.
   PubMed Web of Science ®Google Scholar
• Elumalai P, Lakshmi S. Role of quercetin benefits in neurodegeneration. Adv Neurobiol. 2016;12:229–245.
   PubMedGoogle Scholar
• Caruana M, Cauchi R, Vassallo N. Putative role of Red wine polyphenols against brain pathology in Alzheimer's and Parkinson's disease. Front Nutr. 2016;3:31.
   PubMed Web of Science ®Google Scholar
• Arbo BD, Andre-Miral C, Nasre-Nasser RG, Schimith LE, Santos MG, Costa-Silva D, et al. Resveratrol derivatives as potential treatments for Alzheimer's and Parkinson's disease. Front Aging Neurosci. 2020;12:103.
   PubMed Web of Science ®Google Scholar
• Zhang F, Shi JS, Zhou H, Wilson B, Hong JS, Gao HM. Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions. Mol Pharmacol. 2010;78(3):466–477.
   PubMed Web of Science ®Google Scholar
• Sawda C, Moussa C, Turner RS. Resveratrol for Alzheimer's disease. Ann N Y Acad Sci. 2017;1403(1):142–149.
   PubMed Web of Science ®Google Scholar
• Hernan MA, Chen H, Schwarzschild MA, Ascherio A. Alcohol consumption and the incidence of Parkinson's disease. Ann Neurol. 2003;54(2):170–175.
   PubMed Web of Science ®Google Scholar
• Palacios N, Gao X, O'Reilly E, Schwarzschild M, McCullough ML, Mayo T, et al. Alcohol and risk of Parkinson's disease in a large, prospective cohort of men and women. Mov Disord. 2012;27(8):980–987.
   PubMed Web of Science ®Google Scholar
• Jardim FR, de Rossi FT, Nascimento MX, da Silva Barros RG, Borges PA, Prescilio IC, de Oliveira MR. Resveratrol and brain mitochondria: a review. Mol Neurobiol. 2018;55(3):2085–2101.
   PubMed Web of Science ®Google Scholar
• Rossi M, Caruso F, Kwok L, Lee G, Caruso A, Gionfra F, et al. Protection by extra virgin olive oil against oxidative stress in vitro and in vivo. chemical and biological studies on the health benefits due to a major component of the Mediterranean diet. PLoS One. 2017;12(12):e0189341.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Morato J, Xicota L, Fito M, Farre M, Dierssen M, de la Torre R. Potential role of olive oil phenolic compounds in the prevention of neurodegenerative diseases. Molecules. 2015;20(3):4655–4680.
   PubMed Web of Science ®Google Scholar
• Angeloni C, Malaguti M, Barbalace MC, Hrelia S. Bioactivity of olive Oil phenols in neuroprotection. Int J Mol Sci. 2017;18(11):2230.
   PubMed Web of Science ®Google Scholar
• Khalatbary AR. Olive oil phenols and neuroprotection. Nutr Neurosci. 2013;16(6):243–249.
   PubMed Web of Science ®Google Scholar
• Garcia-Moreno JC, Porta de la Riva M, Martinez-Lara E, Siles E, Canuelo A. Tyrosol, a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson's disease. Neurobiol Aging. 2019;82:60–68.
   PubMed Web of Science ®Google Scholar
• Pathania A, Kumar R, Sandhir R. Hydroxytyrosol as anti-parkinsonian molecule: assessment using in-silico and MPTP-induced Parkinson's disease model. Biomed Pharmacother. 2021;139:111525.
   PubMed Web of Science ®Google Scholar
• Gallardo-Fernandez M, Hornedo-Ortega R, Alonso-Bellido IM, Rodriguez-Gomez JA, Troncoso AM, Garcia-Parrilla MC, et al. Hydroxytyrosol decreases LPS- and alpha-synuclein-induced microglial activation In vitro. Antioxidants (Basel). 2019;9(1):36.
   PubMedGoogle Scholar
• Christine CW, Auinger P, Joslin A, Yelpaala Y, Green R, Parkinson Study Group DI. Vitamin B12 and homocysteine levels predict different outcomes in early Parkinson's disease. Mov Disord. 2018;33(5):762–770.
   PubMed Web of Science ®Google Scholar
• McCarter SJ, Teigen LM, McCarter AR, Benarroch EE, St Louis EK, Savica R. Low vitamin B12 and Parkinson disease: potential link to reduced cholinergic transmission and severity of disease. Mayo Clin Proc. 2019;94(5):757–762.
   PubMed Web of Science ®Google Scholar
• Li S, Zhang Q, Gao Y, Nie K, Liang Y, Zhang Y, Wang L. Serum folate, vitamin B12 levels, and systemic immune-inflammation index correlate with motor performance in Parkinson's disease: a cross-sectional study. Front Neurol. 2021;12:665075.
   PubMed Web of Science ®Google Scholar
• de Lau LM, Koudstaal PJ, Witteman JC, Hofman A, Breteler MM. Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease. Neurology. 2006;67(2):315–318.
   PubMed Web of Science ®Google Scholar
• Chen H, Zhang SM, Schwarzschild MA, Hernan MA, Logroscino G, Willett WC, Ascherio A. Folate intake and risk of Parkinson's disease. Am J Epidemiol. 2004a;160(4):368–375.
   PubMed Web of Science ®Google Scholar
• Ide K, Yamada H, Umegaki K, Mizuno K, Kawakami N, Hagiwara Y, et al. Lymphocyte vitamin C levels as potential biomarker for progression of Parkinson's disease. Nutrition. 2015;31(2):406–408.
   PubMed Web of Science ®Google Scholar
• Hantikainen E, Lagerros YT, Ye W, Serafini M, Adami HO, Bellocco R, Bonn S. Dietary antioxidants and the risk of Parkinson disease: The swedish national march cohort. Neurology. 2021a;96(6):e895–e903.
   Web of Science ®Google Scholar
• Sleeman I, Aspray T, Lawson R, Coleman S, Duncan G, Khoo TK, et al. The role of vitamin D in disease progression in early Parkinson's disease. J Parkinsons Dis. 2017;7(4):669–675.
   PubMedGoogle Scholar
• Zhou Z, Zhou R, Zhang Z, Li K. The association between vitamin D status, vitamin D supplementation, sunlight exposure, and Parkinson's disease: A systematic review and meta-analysis. Med Sci Monit. 2019;25:666–674.
   PubMed Web of Science ®Google Scholar
• Taghizadeh M, Tamtaji OR, Dadgostar E, Daneshvar Kakhaki R, Bahmani F, Abolhassani J, et al. The effects of omega-3 fatty acids and vitamin E co-supplementation on clinical and metabolic status in patients with Parkinson's disease: A randomized, double-blind, placebo-controlled trial. Neurochem Int. 2017;108:183–189.
   PubMed Web of Science ®Google Scholar
• Zhang SM, Hernan MA, Chen H, Spiegelman D, Willett WC, Ascherio A. Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk. Neurology. 2002;59(8):1161–1169.
   PubMed Web of Science ®Google Scholar
• Tamtaji OR, Heidari-Soureshjani R, Mirhosseini N, Kouchaki E, Bahmani F, Aghadavod E, et al. Probiotic and selenium co-supplementation, and the effects on clinical, metabolic and genetic status in Alzheimer's disease: A randomized, double-blind, controlled trial. Clin Nutr. 2019a;38(6):2569–2575.
   PubMed Web of Science ®Google Scholar
• Lopez-Gambero AJ, Martinez F, Salazar K, Cifuentes M, Nualart F. Brain glucose-sensing mechanism and energy homeostasis. Mol Neurobiol. 2019;56(2):769–796.
   PubMed Web of Science ®Google Scholar
• Wang A, Lin Y, Wu Y, Zhang D. Macronutrients intake and risk of Parkinson's disease: A meta-analysis. Geriatr Gerontol Int. 2015;15(5):606–616.
   PubMed Web of Science ®Google Scholar
• Pagano G, Polychronis S, Wilson H, Giordano B, Ferrara N, Niccolini F, Politis M. Diabetes mellitus and Parkinson disease. Neurology. 2018;90(19):e1654–e1662.
   PubMed Web of Science ®Google Scholar
• Liu YS, Wu QJ, Lv JL, Jiang YT, Sun H, Xia Y, et al. Dietary carbohydrate and diverse Health outcomes: umbrella review of 30 systematic reviews and meta-analyses of 281 observational studies. Front Nutr. 2021;8:670411.
   PubMed Web of Science ®Google Scholar
• Ashraghi MR, Pagano G, Polychronis S, Niccolini F, Politis M. Parkinson's disease, diabetes and cognitive impairment. Recent Pat Endocr Metab Immune Drug Discov. 2016;10(1):11–21.
   PubMed Web of Science ®Google Scholar
• Marques A, Dutheil F, Durand E, Rieu I, Mulliez A, Fantini ML, et al. Glucose dysregulation in Parkinson's disease: Too much glucose or not enough insulin? Parkinsonism Relat Disord. 2018;55:122–127.
   PubMed Web of Science ®Google Scholar
• Akhtar A, Sah SP. Insulin signaling pathway and related molecules: role in neurodegeneration and Alzheimer's disease. Neurochem Int. 2020;135:104707.
   PubMed Web of Science ®Google Scholar
• Athauda D, Foltynie T. Insulin resistance and Parkinson's disease: A new target for disease modification? Prog Neurobiol. 2016;145–146:98–120.
   PubMed Web of Science ®Google Scholar
• Kim DS, Choi HI, Wang Y, Luo Y, Hoffer BJ, Greig NH. A New treatment strategy for Parkinson's disease through the gut-brain axis: The glucagon-like peptide-1 receptor pathway. Cell Transplant. 2017;26(9):1560–1571.
   PubMed Web of Science ®Google Scholar
• Fiory F, Perruolo G, Cimmino I, Cabaro S, Pignalosa FC, Miele C, et al. The relevance of insulin action in the dopaminergic system. Front Neurosci. 2019;13:868.
   PubMed Web of Science ®Google Scholar
• Sanchez-Gomez A, Alcarraz-Vizan G, Fernandez M, Fernandez-Santiago R, Ezquerra M, Camara A, et al. Peripheral insulin and amylin levels in Parkinson's disease. Parkinsonism Relat Disord. 2020;79:91–96.
   PubMed Web of Science ®Google Scholar
• Yang L, Wang H, Liu L, Xie A. The role of insulin/IGF-1/PI3 K/Akt/GSK3beta signaling in Parkinson's disease dementia. Front Neurosci. 2018;12:73.
   PubMed Web of Science ®Google Scholar
• Granado M, Amor S, Martin-Carro B, Guerra-Menendez L, Tejera-Munoz A, Gonzalez-Hedstrom D, et al. Caloric restriction attenuates aging-induced cardiac insulin resistance in male Wistar rats through activation of PI3 K/Akt pathway. Nutr Metab Cardiovasc Dis. 2019;29(1):97–105.
   PubMed Web of Science ®Google Scholar
• Gupta D, Krueger CB, Lastra G. Over-nutrition, obesity and insulin resistance in the development of beta-cell dysfunction. Curr Diabetes Rev. 2012;8(2):76–83.
   PubMedGoogle Scholar
• Hu G, Jousilahti P, Bidel S, Antikainen R, Tuomilehto J. Type 2 diabetes and the risk of Parkinson's disease. Diabetes Care. 2007;30(4):842–847.
   PubMed Web of Science ®Google Scholar
• Bohnen NI, Kotagal V, Muller ML, Koeppe RA, Scott PJ, Albin RL, et al. Diabetes mellitus is independently associated with more severe cognitive impairment in Parkinson disease. Parkinsonism Relat Disord. 2014;20(12):1394–1398.
   PubMed Web of Science ®Google Scholar
• Yang YW, Hsieh TF, Li CI, Liu CS, Lin WY, Chiang JH, et al. Increased risk of Parkinson disease with diabetes mellitus in a population-based study. Medicine (Baltimore). 2017b;96(3):e5921.
   PubMed Web of Science ®Google Scholar
• Xu Q, Park Y, Huang X, Hollenbeck A, Blair A, Schatzkin A, Chen H. Diabetes and risk of Parkinson's disease. Diabetes Care. 2011;34(4):910–915.
   PubMed Web of Science ®Google Scholar
• De Pablo-Fernandez E, Goldacre R, Pakpoor J, Noyce AJ, Warner TT. Association between diabetes and subsequent Parkinson disease: A record-linkage cohort study. Neurology. 2018;91(2):e139–e142.
   PubMed Web of Science ®Google Scholar
• Sun Y, Chang YH, Chen HF, Su YH, Su HF, Li CY. Risk of Parkinson disease onset in patients with diabetes: a 9-year population-based cohort study with age and sex stratifications. Diabetes Care. 2012;35(5):1047–1049.
   PubMed Web of Science ®Google Scholar
• Yue X, Li H, Yan H, Zhang P, Chang L, Li T. Risk of Parkinson disease in diabetes mellitus: An updated meta-analysis of population-based cohort studies. Medicine (Baltimore). 2016;95(18):e3549.
   PubMed Web of Science ®Google Scholar
• Driver JA, Smith A, Buring JE, Gaziano JM, Kurth T, Logroscino G. Prospective cohort study of type 2 diabetes and the risk of Parkinson's disease. Diabetes Care. 2008;31(10):2003–2005.
   PubMed Web of Science ®Google Scholar
• Brauer R, Wei L, Ma T, Athauda D, Girges C, Vijiaratnam N, et al. Diabetes medications and risk of Parkinson's disease: a cohort study of patients with diabetes. Brain. 2020;143(10):3067–3076.
   PubMedGoogle Scholar
• Ou R, Wei Q, Hou Y, Zhang L, Liu K, Lin J, et al. Effect of diabetes control status on the progression of Parkinson's disease: A prospective study. Ann Clin Transl Neurol. 2021;8(4):887–897.
   PubMed Web of Science ®Google Scholar
• Cheong JLY, de Pablo-Fernandez E, Foltynie T, Noyce AJ. The association between type 2 diabetes mellitus and Parkinson's disease. J Parkinsons Dis. 2020;10(3):775–789.
   PubMedGoogle Scholar
• Murakami K, Miyake Y, Sasaki S, Tanaka K, Fukushima W, Kiyohara C, et al. Dietary glycemic index is inversely associated with the risk of Parkinson's disease: a case-control study in Japan. Nutrition. 2010a;26(5):515–521.
   PubMed Web of Science ®Google Scholar
• Qu Y, Chen X, Xu MM, Sun Q. Relationship between high dietary fat intake and Parkinson's disease risk: a meta-analysis. Neural Regen Res. 2019;14(12):2156–2163.
   PubMed Web of Science ®Google Scholar
• Tana C, Ticinesi A, Prati B, Nouvenne A, Meschi T. Uric acid and cognitive function in older individuals. Nutrients. 2018;10(8):975.
   PubMed Web of Science ®Google Scholar
• Huang X, Ng SY, Chia NS, Acharyya S, Setiawan F, Lu ZH, et al. Serum uric acid level and its association with motor subtypes and non-motor symptoms in early Parkinson's disease: PALS study. Parkinsonism Relat Disord. 2018;55:50–54.
   PubMed Web of Science ®Google Scholar
• van Wamelen DJ, Taddei RN, Calvano A, Titova N, Leta V, Shtuchniy I, et al. Serum uric acid levels and Non-motor symptoms in Parkinson's disease. J Parkinsons Dis. 2020;10(3):1003–1010.
   PubMedGoogle Scholar
• Koros C, Simitsi AM, Papadimitriou D, Bougea A, Prentakis A, Papagiannakis N, et al. Serum uric acid level as a biomarker in idiopathic and genetic (p.A53 T alpha-synuclein carriers) Parkinson's disease: data from the PPMI study. J Parkinsons Dis. 2020;10(2):481–487.
   PubMedGoogle Scholar
• Belaidi AA, Bush AI. Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics. J Neurochem. 2016;139(Suppl 1):179–197.
   PubMedGoogle Scholar
• Powers KM, Smith-Weller T, Franklin GM, Longstreth WT, Jr., Swanson PD, Checkoway H. Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes. Neurology. 2003;60(11):1761–1766.
   PubMed Web of Science ®Google Scholar
• Mezzaroba L, Alfieri DF, Colado Simao AN, Vissoci Reiche EM. The role of zinc, copper, manganese and iron in neurodegenerative diseases. Neurotoxicology. 2019;74:230–241.
   PubMed Web of Science ®Google Scholar
• Rozani V, Giladi N, Gurevich T, El-Ad B, Tsamir J, Hemo B, Peretz C. Anemia in men and increased Parkinson's disease risk: A population-based large scale cohort study. Parkinsonism Relat Disord. 2019;64:90–96.
   PubMed Web of Science ®Google Scholar
• Du K, Liu MY, Zhong X, Wei MJ. Decreased circulating zinc levels in Parkinson's disease: a meta-analysis study. Sci Rep. 2017;7(1):3902.
   PubMedGoogle Scholar
• Wojtunik-Kulesza K, Oniszczuk A, Waksmundzka-Hajnos M. An attempt to elucidate the role of iron and zinc ions in development of Alzheimer's and Parkinson's diseases. Biomed Pharmacother. 2019;111:1277–1289.
   PubMed Web of Science ®Google Scholar
• Benedetti MD, Bower JH, Maraganore DM, McDonnell SK, Peterson BJ, Ahlskog JE, et al. Smoking, alcohol, and coffee consumption preceding Parkinson's disease: a case-control study. Neurology. 2000;55(9):1350–1358.
   PubMed Web of Science ®Google Scholar
• Checkoway H, Powers K, Smith-Weller T, Franklin GM, Longstreth WT, Jr., Swanson PD. Parkinson's disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake. Am J Epidemiol. 2002;155(8):732–738.
   PubMed Web of Science ®Google Scholar
• Ragonese P, Salemi G, Morgante L, Aridon P, Epifanio A, Buffa D, et al. A case-control study on cigarette, alcohol, and coffee consumption preceding Parkinson's disease. Neuroepidemiology. 2003;22(5):297–304.
   PubMed Web of Science ®Google Scholar
• Paganini-Hill A. Risk factors for Parkinson's disease: the leisure world cohort study. Neuroepidemiology. 2001;20(2):118–124.
   PubMed Web of Science ®Google Scholar
• Eriksson AK, Lofving S, Callaghan RC, Allebeck P. Alcohol use disorders and risk of Parkinson's disease: findings from a Swedish national cohort study 1972–2008. BMC Neurol. 2013;13:190.
   PubMed Web of Science ®Google Scholar
• Zhang D, Jiang H, Xie J. Alcohol intake and risk of Parkinson's disease: a meta-analysis of observational studies. Mov Disord. 2014;29(6):819–822.
   PubMed Web of Science ®Google Scholar
• Jimenez-Jimenez FJ, Alonso-Navarro H, Garcia-Martin E, Agundez JAG. Alcohol consumption and risk for Parkinson's disease: a systematic review and meta-analysis. J Neurol. 2019;266(8):1821–1834.
   PubMed Web of Science ®Google Scholar
• Bettiol SS, Rose TC, Hughes CJ, Smith LA. Alcohol consumption and Parkinson's disease risk: a review of Recent findings. J Parkinsons Dis. 2015;5(3):425–442.
   PubMedGoogle Scholar
• Ren X, Chen JF. Caffeine and Parkinson's disease: multiple benefits and emerging mechanisms. Front Neurosci. 2020;14:602697.
   PubMed Web of Science ®Google Scholar
• Chen JF. The adenosine A(2A) receptor as an attractive target for Parkinson's disease treatment. Drug News Perspect. 2003;16(9):597–604.
   PubMedGoogle Scholar
• Cho BH, Choi SM, Kim JT, Kim BC. Association of coffee consumption and non-motor symptoms in drug-naive, early-stage Parkinson's disease. Parkinsonism Relat Disord. 2018;50:42–47.
   PubMed Web of Science ®Google Scholar
• Wills AM, Eberly S, Tennis M, Lang AE, Messing S, Togasaki D, et al. Caffeine consumption and risk of dyskinesia in CALM-PD. Mov Disord. 2013;28(3):380–383.
   PubMed Web of Science ®Google Scholar
• Hong CT, Chan L, Bai CH. The effect of caffeine on the risk and progression of Parkinson's disease: A meta-analysis. Nutrients. 2020;12(6):1860.
   Web of Science ®Google Scholar
• Tamtaji OR, Taghizadeh M, Daneshvar Kakhaki R, Kouchaki E, Bahmani F, Borzabadi S, et al. Clinical and metabolic response to probiotic administration in people with Parkinson's disease: A randomized, double-blind, placebo-controlled trial. Clin Nutr. 2019b;38(3):1031–1035.
   PubMed Web of Science ®Google Scholar
• Gerhardt S, Mohajeri MH. Changes of colonic bacterial composition in Parkinson's disease and other neurodegenerative diseases. Nutrients. 2018;10(6):708.
   PubMed Web of Science ®Google Scholar
• Patel RM, Myers LS, Kurundkar AR, Maheshwari A, Nusrat A, Lin PW. Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function. Am J Pathol. 2012;180(2):626–635.
   PubMed Web of Science ®Google Scholar
• Reid G, Younes JA, Van der Mei HC, Gloor GB, Knight R, Busscher HJ. Microbiota restoration: natural and supplemented recovery of human microbial communities. Nat Rev Microbiol. 2011;9(1):27–38.
   PubMed Web of Science ®Google Scholar
• Zaharoni H, Rimon E, Vardi H, Friger M, Bolotin A, Shahar DR. Probiotics improve bowel movements in hospitalized elderly patients–the PROAGE study. J Nutr Health Aging. 2011;15(3):215–220.
   PubMed Web of Science ®Google Scholar
• Cassani E, Privitera G, Pezzoli G, Pusani C, Madio C, Iorio L, Barichella M. Use of probiotics for the treatment of constipation in Parkinson's disease patients. Minerva Gastroenterol Dietol. 2011;57(2):117–121.
   PubMedGoogle Scholar
• Clairembault T, Leclair-Visonneau L, Neunlist M, Derkinderen P. Enteric glial cells: new players in Parkinson's disease? Mov Disord. 2015;30(4):494–498.
   PubMed Web of Science ®Google Scholar
• Klingelhoefer L, Reichmann H. Pathogenesis of Parkinson disease–the gut-brain axis and environmental factors. Nat Rev Neurol. 2015;11(11):625–636.
   PubMed Web of Science ®Google Scholar
• Borre YE, Moloney RD, Clarke G, Dinan TG, Cryan JF. The impact of microbiota on brain and behavior: mechanisms & therapeutic potential. Adv Exp Med Biol. 2014;817:373–403.
   PubMed Web of Science ®Google Scholar
• Hawkes CH, Del Tredici K, Braak H. Parkinson's disease: the dual hit theory revisited. Ann N Y Acad Sci. 2009;1170:615–622.
   PubMed Web of Science ®Google Scholar
• Keshavarzian A, Green SJ, Engen PA, Voigt RM, Naqib A, Forsyth CB, et al. Colonic bacterial composition in Parkinson's disease. Mov Disord. 2015;30(10):1351–1360.
   PubMed Web of Science ®Google Scholar
• Martinez-Martin P. The importance of non-motor disturbances to quality of life in Parkinson's disease. J Neurol Sci. 2011;310(1–2):12–16.
   PubMed Web of Science ®Google Scholar
• Gold A, Turkalp ZT, Munoz DG. Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease. Mov Disord. 2013;28(2):237–240.
   PubMed Web of Science ®Google Scholar
• Shanahan F, van Sinderen D, O'Toole PW, Stanton C. Feeding the microbiota: transducer of nutrient signals for the host. Gut. 2017;66(9):1709–1717.
   PubMed Web of Science ®Google Scholar
• Metcalfe-Roach A, Yu AC, Golz E, Cirstea M, Sundvick K, Kliger D, et al. MIND and Mediterranean diets associated with later onset of Parkinson's disease. Mov Disord. 2021b;36(4):977–984.
   PubMed Web of Science ®Google Scholar
• Garcia-Mantrana I, Selma-Royo M, Alcantara C, Collado MC. Shifts on gut microbiota associated to Mediterranean diet adherence and specific dietary intakes on general adult population. Front Microbiol. 2018;9:890.
   PubMed Web of Science ®Google Scholar
• Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, et al. Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease. Cell. 2016;167(6):1469–1480 e1412.
   PubMed Web of Science ®Google Scholar
• Aleksandrova K, Romero-Mosquera B, Hernandez V. Diet, Gut microbiome and epigenetics: emerging links with inflammatory bowel diseases and prospects for management and prevention. Nutrients. 2017;9(9):962.
   PubMed Web of Science ®Google Scholar
• Sun MF, Shen YQ. Dysbiosis of gut microbiota and microbial metabolites in Parkinson's disease. Ageing Res Rev. 2018;45:53–61.
   PubMed Web of Science ®Google Scholar
• Boulos C, Yaghi N, El Hayeck R, Heraoui GN, Fakhoury-Sayegh N. Nutritional risk factors, microbiota and Parkinson's disease: what is the current evidence? Nutrients. 2019;11:8.
   Web of Science ®Google Scholar
• Del Chierico F, Vernocchi P, Dallapiccola B, Putignani L. Mediterranean diet and health: food effects on gut microbiota and disease control. Int J Mol Sci. 2014;15(7):11678–11699.
   PubMed Web of Science ®Google Scholar
• Mitsou EK, Kakali A, Antonopoulou S, Mountzouris KC, Yannakoulia M, Panagiotakos DB, Kyriacou A. Adherence to the Mediterranean diet is associated with the gut microbiota pattern and gastrointestinal characteristics in an adult population. Br J Nutr. 2017;117(12):1645–1655.
   PubMed Web of Science ®Google Scholar
• Daniel M, Tollefsbol TO. Epigenetic linkage of aging, cancer and nutrition. J Exp Biol. 2015;218(Pt 1):59–70.
   PubMed Web of Science ®Google Scholar
• Alam R, Abdolmaleky HM, Zhou JR. Microbiome, inflammation, epigenetic alterations, and mental diseases. Am J Med Genet B Neuropsychiatr Genet. 2017;174(6):651–660.
   PubMed Web of Science ®Google Scholar
• Ding S, Jiang J, Zhang G, Bu Y, Zhang G, Zhao X. Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat diet-fed rats. PLoS One. 2017;12(8):e0183541.
   PubMed Web of Science ®Google Scholar
• Li X, Feng Y, Wang XX, Truong D, Wu YC. The critical role of SIRT1 in Parkinson's disease: mechanism and therapeutic considerations. Aging Dis. 2020;11(6):1608–1622.
   PubMed Web of Science ®Google Scholar
• Suttrup I, Warnecke T. Dysphagia in Parkinson's disease. Dysphagia. 2016;31(1):24–32.
   PubMed Web of Science ®Google Scholar
• McCrimmon RJ, Ryan CM, Frier BM. Diabetes and cognitive dysfunction. Lancet. 2012;379(9833):2291–2299.
   PubMed Web of Science ®Google Scholar
• Liu Z, Zaid M, Hisamatsu T, Tanaka S, Fujiyoshi A, Miyagawa N, et al. Elevated fasting blood glucose levels Are associated With lower cognitive function, With a threshold in Non-diabetic individuals: A population-based study. J Epidemiol. 2020;30(3):121–127.
   PubMed Web of Science ®Google Scholar
• Lang AE, Espay AJ. Disease modification in Parkinson's disease: current approaches, challenges, and future considerations. Mov Disord. 2018;33(5):660–677.
   PubMed Web of Science ®Google Scholar
• Prins BP, Abbasi A, Wong A, Vaez A, Nolte I, Franceschini N, et al. Investigating the causal relationship of C-reactive protein with 32 complex somatic and psychiatric outcomes: A large-scale cross-consortium Mendelian randomization study. PLoS Med. 2016;13(6):e1001976.
   PubMed Web of Science ®Google Scholar
• Potashkin J, Huang X, Becker C, Chen H, Foltynie T, Marras C. Understanding the links between cardiovascular disease and Parkinson's disease. Mov Disord. 2020;35(1):55–74.
   PubMed Web of Science ®Google Scholar
• Kizza J, Lewington S, Mappin-Kasirer B, Turnbull I, Guo Y, Bian Z, et al. Cardiovascular risk factors and Parkinson's disease in 500,000 Chinese adults. Ann Clin Transl Neurol. 2019;6(4):624–632.
   PubMed Web of Science ®Google Scholar
• Nicoletti A, Luca A, Baschi R, Cicero CE, Mostile G, Davi M, et al. Vascular risk factors, white matter lesions and cognitive impairment in Parkinson's disease: the PACOS longitudinal study. J Neurol. 2021;268(2):549–558.
   PubMed Web of Science ®Google Scholar
• Schwartz RS, Halliday GM, Soh D, Cordato DJ, Kril JJ. Impact of small vessel disease on severity of motor and cognitive impairment in Parkinson's disease. J Clin Neurosci. 2018;58:70–74.
   PubMed Web of Science ®Google Scholar
• Chung SJ, Jeon S, Yoo HS, Kim G, Oh JS, Kim JS, et al. Detrimental effect of type 2 diabetes mellitus in a large case series of Parkinson's disease. Parkinsonism Relat Disord. 2019;64:54–59.
   PubMed Web of Science ®Google Scholar
• Lu L, Fu DL, Li HQ, Liu AJ, Li JH, Zheng GQ. Diabetes and risk of Parkinson's disease: an updated meta-analysis of case-control studies. PLoS One. 2014;9(1):e85781.
   PubMed Web of Science ®Google Scholar
• De Pablo-Fernandez E, Sierra-Hidalgo F, Benito-Leon J, Bermejo-Pareja F. Association between Parkinson's disease and diabetes: data from NEDICES study. Acta Neurol Scand. 2017;136(6):732–736.
   PubMed Web of Science ®Google Scholar
• Morris JK, Vidoni ED, Perea RD, Rada R, Johnson DK, Lyons K, et al. Insulin resistance and gray matter volume in neurodegenerative disease. Neuroscience. 2014;270:139–147.
   PubMed Web of Science ®Google Scholar
• Mahlknecht P, Sprenger F, Seppi K, Poewe W. Plasma fasting cholesterol profiles and age at onset in Parkinson's disease. Mov Disord. 2015;30(14):1974–1975.
   PubMed Web of Science ®Google Scholar
• Sterling NW, Lichtenstein M, Lee EY, Lewis MM, Evans A, Eslinger PJ, et al. Higher plasma LDL-cholesterol is associated with preserved executive and fine motor functions in Parkinson's disease. Aging Dis. 2016;7(3):237–245.
   PubMed Web of Science ®Google Scholar
• Goritz C, Mauch DH, Pfrieger FW. Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuron. Mol Cell Neurosci. 2005;29(2):190–201.
   PubMed Web of Science ®Google Scholar
• Zhang P, Tian B. Metabolic syndrome: an important risk factor for Parkinson's disease. Oxid Med Cell Longev. 2014;2014:729194.
   PubMed Web of Science ®Google Scholar
• Melendez-Flores JD, Castillo-Torres SA, Cerda-Contreras C, Chavez-Luevanos B, Estrada-Bellmann I. Clinical features of metabolic syndrome in patients with Parkinson's disease. Rev Neurol. 2021;72(1):9–15.
   PubMed Web of Science ®Google Scholar
• Roh JH, Lee S, Yoon JH. Metabolic syndrome and Parkinson's disease incidence: a nationwide study using propensity score matching. Metab Syndr Relat Disord. 2021;19(1):1–7.
   PubMed Web of Science ®Google Scholar
• Ditano-Vazquez P, Torres-Pena JD, Galeano-Valle F, Perez-Caballero AI, Demelo-Rodriguez P, Lopez-Miranda J, et al. The fluid aspect of the Mediterranean diet in the prevention and management of cardiovascular disease and diabetes: The role of polyphenol content in moderate consumption of wine and olive oil. Nutrients. 2019;11(11):2833.
   PubMed Web of Science ®Google Scholar
• Sulmont-Rosse C, Gaillet M, Raclot C, Duclos M, Servelle M, Chambaron S. Impact of olfactory priming on food intake in an Alzheimer's disease unit. J Alzheimers Dis. 2018;66(4):1497–1506.
   PubMed Web of Science ®Google Scholar
• Miwa H, Kondo T. Alteration of eating behaviors in patients with Parkinson's disease: possibly overlooked? Neurocase. 2008;14(6):480–484.
   PubMed Web of Science ®Google Scholar
• Morgante F, Fasano A, Ginevrino M, Petrucci S, Ricciardi L, Bove F, et al. Impulsive-compulsive behaviors in parkin-associated Parkinson disease. Neurology. 2016;87(14):1436–1441.
   PubMed Web of Science ®Google Scholar
• Muller J, Myers J. Association between physical fitness, cardiovascular risk factors, and Parkinson's disease. Eur J Prev Cardiol. 2018;25(13):1409–1415.
   PubMed Web of Science ®Google Scholar
• Shamoto-Nagai M, Hisaka S, Naoi M, Maruyama W. Modification of alpha-synuclein by lipid peroxidation products derived from polyunsaturated fatty acids promotes toxic oligomerization: its relevance to Parkinson disease. J Clin Biochem Nutr. 2018;62(3):207–212.
   PubMed Web of Science ®Google Scholar
• Keshavarzian A, Engen P, Bonvegna S, Cilia R. The gut microbiome in Parkinson's disease: A culprit or a bystander? Prog Brain Res. 2020;252:357–450.
   PubMed Web of Science ®Google Scholar