Morin and isoquercitrin protect against ischemic neuronal injury by modulating signaling pathways and stimulating mitochondrial biogenesis

References

• Fujii H, Takahashi T, Mukai T, Tanaka S, Hosomi N, Maruyama H, et al. Modifications of tau protein after cerebral ischemia and reperfusion in rats are similar to those occurring in Alzheimer's disease - hyperphosphorylation and cleavage of 4- and 3-repeat tau. J Cereb Blood Flow Metab. 2017;37:2441–57.
   PubMed Web of Science ®Google Scholar
• Pluta R, Ułamek-Kozioł M, Januszewski S, Czuczwar SJ. Common proteomic and genomic contribution to ischemic brain damage and Alzheimer’s disease. In: Wisniewski T, editor. Alzheimer’s disease. Brisbane, AU: Codon Publications Copyright: The Authors.; 2019.
   Google Scholar
• Pluta R, Furmaga-Jabłońska W, Maciejewski R, Ułamek-Kozioł M, Jabłoński M. Brain ischemia activates β- and γ-secretase cleavage of amyloid precursor protein: significance in sporadic Alzheimer's disease. Mol Neurobiol. 2013;47:425–34.
   PubMed Web of Science ®Google Scholar
• Nalivaeva NN, Turner AJ. Role of ageing and oxidative stress in regulation of amyloid-degrading enzymes and development of neurodegeneration. Curr Aging Sci. 2017;10:32–40.
   PubMedGoogle Scholar
• Szczechowiak K, Diniz BS, Leszek J. Diet and Alzheimer's dementia - Nutritional approach to modulate inflammation. Pharmacol Biochem Behav. 2019;184:172743.
   PubMed Web of Science ®Google Scholar
• Spencer JP. Flavonoids: modulators of brain function? Br J Nutr. 2008;99(E Suppl 1):Es60–77.
   PubMedGoogle Scholar
• Carmona V, Martín-Aragón S, Goldberg J, Schubert D, Bermejo-Bescós P. Several targets involved in Alzheimer’s disease amyloidogenesis are affected by morin and isoquercitrin. Nutr Neurosci. 2020;23:575–90.
   PubMed Web of Science ®Google Scholar
• Maher P, Salgado KF, Zivin JA, Lapchak PA. A novel approach to screening for new neuroprotective compounds for the treatment of stroke. Brain Res. 2007;1173:117–25.
   PubMed Web of Science ®Google Scholar
• Altunoglu E, Guntas G, Erdenen F, Akkaya E, Topac I, Irmak H, et al. Ischemia-modified albumin and advanced oxidation protein products as potential biomarkers of protein oxidation in Alzheimer's disease. Geriatr Gerontol Int. 2015;15:872–80.
   PubMed Web of Science ®Google Scholar
• Mehta SL, Manhas N, Raghubir R. Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res Rev. 2007;54:34–66.
   PubMed Web of Science ®Google Scholar
• Gohil VM, Sheth SA, Nilsson R, Wojtovich AP, Lee JH, Perocchi F, et al. Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. Nat Biotechnol. 2010;28:249–55.
   PubMed Web of Science ®Google Scholar
• de Oliveira MR, Nabavi SM, Braidy N, Setzer WN, Ahmed T, Nabavi SF. Quercetin and the mitochondria: A mechanistic view. Biotechnol Adv. 2016;34:532–49.
   PubMed Web of Science ®Google Scholar
• Skemiene K, Liobikas J, Borutaite V. Anthocyanins as substrates for mitochondrial complex I - protective effect against heart ischemic injury. Febs j. 2015;282:963–71.
   PubMed Web of Science ®Google Scholar
• Lagoa R, Graziani I, Lopez-Sanchez C, Garcia-Martinez V, Gutierrez-Merino C. Complex I and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria. Biochim Biophys Acta. 2011;1807:1562–72.
   PubMed Web of Science ®Google Scholar
• Sandoval-Acuña C, Ferreira J, Speisky H. Polyphenols and mitochondria: an update on their increasingly emerging ROS-scavenging independent actions. Arch Biochem Biophys. 2014;559:75–90.
   PubMed Web of Science ®Google Scholar
• Castellano-González G, Pichaud N, Ballard JW, Bessede A, Marcal H, Guillemin GJ. Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase in human cultured neurons and astrocytes. Oncotarget. 2016;7:7426–40.
   PubMedGoogle Scholar
• Procházková D, Boušová I, Wilhelmová N. Antioxidant and prooxidant properties of flavonoids. Fitoterapia. 2011;82:513–23.
   PubMed Web of Science ®Google Scholar
• Knorre DA, Severin FF. Uncouplers of oxidation and phosphorylation as antiaging compounds. Biochemistry (Mosc). 2016;81:1438–44.
   PubMed Web of Science ®Google Scholar
• Koronowski KB, Dave KR, Saul I, Camarena V, Thompson JW, Neumann JT, et al. Resveratrol preconditioning induces a novel extended window of ischemic tolerance in the mouse brain. Stroke. 2015;46:2293–8.
   PubMed Web of Science ®Google Scholar
• Fraga CG, Galleano M, Verstraeten SV, Oteiza PI. Basic biochemical mechanisms behind the health benefits of polyphenols. Mol Aspects Med. 2010;31:435–45.
   PubMed Web of Science ®Google Scholar
• Zhang L, Wu J, Duan X, Tian X, Shen H, Sun Q, Chen G. NADPH oxidase: A potential target for treatment of stroke. Oxid Med Cell Longev. 2016;2016:5026984.
   PubMed Web of Science ®Google Scholar
• Liu C, Wu J, Xu K, Cai F, Gu J, Ma L, Chen J. Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway. J Neurochem. 2010;112:1500–12.
   PubMed Web of Science ®Google Scholar
• Zhang XM, Zhang L, Wang G, Niu W, He Z, Ding L, Jia J. Suppression of mitochondrial fission in experimental cerebral ischemia: The potential neuroprotective target of p38 MAPK inhibition. Neurochem Int. 2015;90:1–8.
   PubMed Web of Science ®Google Scholar
• Benakis C, Bonny C, Hirt L. JNK inhibition and inflammation after cerebral ischemia. Brain Behav Immun. 2010;24:800–11.
   PubMed Web of Science ®Google Scholar
• Zhao L, Liu X, Liang J, Han S, Wang Y, Yin Y, et al. Phosphorylation of p38 MAPK mediates hypoxic preconditioning-induced neuroprotection against cerebral ischemic injury via mitochondria translocation of Bcl-xL in mice. Brain Res. 2013;1503:78–88.
   PubMed Web of Science ®Google Scholar
• Wang M, Li YJ, Ding Y, Zhang HN, Sun T, Zhang K, et al. Silibinin prevents autophagic cell death upon oxidative stress in cortical neurons and cerebral ischemia-reperfusion injury. Mol Neurobiol. 2016;53:932–43.
   PubMed Web of Science ®Google Scholar
• Pilchova I, Klacanova K, Chomova M, Tatarkova Z, Dobrota D, Racay P. Possible contribution of proteins of Bcl-2 family in neuronal death following transient global brain ischemia. Cell Mol Neurobiol. 2015;35:23–31.
   PubMed Web of Science ®Google Scholar
• Weiner GM, Ducruet AF. Mammalian target of rapamycin (mTOR) activity promotes neuronal survival in stroke with or without ischemic postconditioning. Neurosurgery. 2015;76:N19–20.
   PubMed Web of Science ®Google Scholar
• Chuang DM, Wang Z, Chiu CT. GSK-3 as a target for lithium-induced neuroprotection against excitotoxicity in neuronal cultures and animal models of ischemic stroke. Front Mol Neurosci. 2011;4:15.
   PubMed Web of Science ®Google Scholar
• Lapchak PA, Schubert DR, Maher PA. Delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic stroke. J Neurochem. 2011;116:122–31.
   PubMed Web of Science ®Google Scholar