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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 27, 2024 - Issue 7
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Review Article

A systematic review and meta-analysis of the omega-3 fatty acids effects on brain-derived neurotrophic factor (BDNF)

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References

  • Saini RK, Keum Y-S. Omega-3 and omega-6 polyunsaturated fatty acids: dietary sources, metabolism, and significance—A review. Life Sci. 2018;203:255–67.
  • Meng W, Jiang Y, Rothschild D, Lipke M, Hall G, Wang L. Modeling the structure and infrared spectra of omega-3 fatty acid esters. J Chem Phys. 2020;153(3):035101.
  • Singh JE. Dietary sources of omega-3 fatty acids versus omega-3 fatty acid supplementation effects on cognition and inflammation. Curr Nutr Rep. 2020;9:1–14.
  • Shahidi F, Ambigaipalan P. Omega-3 polyunsaturated fatty acids and their health benefits. Annu Rev Food Sci Technol. 2018;9:345–81.
  • Rathod RS, Khaire AA, Kale AA, Joshi SR. Beneficial effects of omega-3 fatty acids and vitamin B12 supplementation on brain docosahexaenoic acid, brain derived neurotrophic factor, and cognitive performance in the second-generation Wistar rats. Biofactors. 2015;41(4):261–72.
  • Sona C, Kumar A, Dogra S, Kumar BA, Umrao D, Yadav PN. Docosahexaenoic acid modulates brain-derived neurotrophic factor via GPR40 in the brain and alleviates diabesity-associated learning and memory deficits in mice. Neurobiol Dis. 2018;118:94–107.
  • Zemdegs J, Rainer Q, Grossmann CP, Rousseau-Ralliard D, Grynberg A, Ribeiro E, et al. Anxiolytic-and antidepressant-like effects of fish oil-enriched diet in brain-derived neurotrophic factor deficient mice. Front Neurosci. 2018;12:974.
  • Notaras M, van den Buuse M. Brain-derived neurotrophic factor (BDNF): novel insights into regulation and genetic variation. Neuroscientist. 2019;25(5):434–54.
  • De Vincenti AP, Ríos AS, Paratcha G, Ledda F. Mechanisms that modulate and diversify BDNF functions: implications for hippocampal synaptic plasticity. Front Cell Neurosci. 2019;13:135.
  • Colucci-D’Amato L, Speranza L, Volpicelli F. Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer. Int J Mol Sci. 2020;21(20):7777.
  • Ng TKS, Ho CSH, Tam WWS, Kua EH, Ho RC-M. Decreased serum brain-derived neurotrophic factor (BDNF) levels in patients with Alzheimer’s disease (AD): a systematic review and meta-analysis. Int J Mol Sci. 2019;20(2):257.
  • Palasz E, Wysocka A, Gasiorowska A, Chalimoniuk M, Niewiadomski W, Niewiadomska G. BDNF as a promising therapeutic agent in Parkinson’s disease. Int J Mol Sci. 2020;21(3):1170.
  • Shen T, You Y, Joseph C, Mirzaei M, Klistorner A, Graham SL, et al. BDNF polymorphism: a review of its diagnostic and clinical relevance in neurodegenerative disorders. Aging Dis. 2018;9(3):523.
  • Calabrese F, Rossetti AC, Racagni G, Gass P, Riva MA, Molteni R. Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity. Front Cell Neurosci. 2014;8:430.
  • Giacobbo BL, Doorduin J, Klein HC, Dierckx RA, Bromberg E, de Vries EF. Brain-derived neurotrophic factor in brain disorders: focus on neuroinflammation. Mol Neurobiol. 2019;56(5):3295–312.
  • Zhang J-c, Yao W, Hashimoto K. Brain-derived neurotrophic factor (BDNF)-TrkB signaling in inflammation-related depression and potential therapeutic targets. Curr Neuropharmacol. 2016;14(7):721–31.
  • Giacobbe J, Benoiton B, Zunszain P, Pariante CM, Borsini A. The anti-inflammatory role of omega-3 polyunsaturated fatty acids metabolites in pre-clinical models of psychiatric, neurodegenerative, and neurological disorders. Front Psychiatry. 2020;11:122.
  • Su K-P, Tseng P-T, Lin P-Y, Okubo R, Chen T-Y, Chen Y-W, et al. Association of use of omega-3 polyunsaturated fatty acids with changes in severity of anxiety symptoms: a systematic review and meta-analysis. JAMA Network Open. 2018;1(5):e182327.
  • Nieto RR, Carrasco A, Corral S, Castillo R, Gaspar PA, Bustamante ML, et al. BDNF as a biomarker of cognition in schizophrenia/psychosis: an updated review. Front Psychiatry. 2021;12:12.
  • Sugasini D, Yalagala PC, Subbaiah PV. Plasma BDNF is a more reliable biomarker than erythrocyte omega-3 index for the omega-3 fatty acid enrichment of brain. Sci Rep. 2020;10(1):1–10.
  • Gravesteijn E, Mensink RP, Plat J. Effects of nutritional interventions on BDNF concentrations in humans: a systematic review. Nutr Neurosci. 2021;25:1–12.
  • Sterne JA, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. Rob 2: a revised tool for assessing risk of bias in randomised trials. Br Med J. 2019;366:366.
  • Agh F, Honarvar NM, Djalali M, Nematipour E, Zarei M, Salim SJ, et al. Brain-derived neurotrophic factor (BDNF) is increased by omega-3 fatty acids in coronary artery disease: a randomized, double-blind, placebo-controlled. J Nutr Sci Diet. 2016;2:2–8.
  • Ansari S, Djalali M, Mohammadzadeh N, Mohammadzadeh Honarvar N, Mazaherioun M, Zarei M, et al. Assessing the effect of omega-3 fatty acids supplementation on serum BDNF (brain derived neurotrophic factor) in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study. Intl Res J Appl Basic Sci. 2016;10(4):380–83.
  • Bot M, Pouwer F, Assies J, Jansen EH, Beekman AT, De Jonge P. Supplementation with eicosapentaenoic omega-3 fatty acid does not influence serum brain-derived neurotrophic factor in diabetes mellitus patients with major depression: a randomized controlled pilot study. Neuropsychobiology. 2011;63(4):219–23.
  • Chang JP-C, Su K-P, Mondelli V, Satyanarayanan SK, Yang H-T, Chiang Y-J, et al. High-dose eicosapentaenoic acid (EPA) improves attention and vigilance in children and adolescents with attention deficit hyperactivity disorder (ADHD) and low endogenous EPA levels. Transl Psychiatry. 2019;9(1):303.
  • Daďová K, Petr M, Tufano JJ, Sontáková L, Krauzová E, Štěpán M, et al. Calanus Oil supplementation does Not further improve short-term memory or brain-derived neurotrophic factor in older women Who underwent exercise training. Clin Interv Aging. 2022;17:1227–1236.
  • Fallah Mohammadi Z, Nazari H. The effects of 4 weeks plyometric training and omega 3 supplementation on serum brain derived neurotrophic factor and C-reactive protein in active men. J Prac Stud Biosci Sport. 2013;1(1):70–82.
  • Karimipour S, Nayebifar S, Fazel Bakhsheshi M. Effect of high intensity interval training and supplementation of omega-3 on serum levels of brain derived neurotrophic factor and resting blood pressure of inactive male students. J Gorgan Univ Med Sci. 2020;22(1):17–26.
  • Matsuoka Y, Nishi D, Tanima Y, Itakura M, Kojima M, Hamazaki K, et al. Serum pro-BDNF/BDNF as a treatment biomarker for response to docosahexaenoic acid in traumatized people vulnerable to developing psychological distress: a randomized controlled trial. Transl Psychiatry. 2015;5(7):e596.
  • Nazari H. The effect of 4 weeks of omega 3 supplementation with plant (flaxseed extract) and animal (fish Oil) origin on serum concentration of brain derived neurotrophic factor (BDNF) following 4 weeks of plyometric training in active Men. J Sport Biosci. 2016;8(2):157–68.
  • Pawełczyk T, Grancow-Grabka M, Trafalska E, Szemraj J, Żurner N, Pawełczyk A. An increase in plasma brain derived neurotrophic factor levels is related to n-3 polyunsaturated fatty acid efficacy in first episode schizophrenia: secondary outcome analysis of the OFFER randomized clinical trial. Psychopharmacology. 2019;236:2811–22.
  • Poorbaferani F, Rouhani MH, Heidari Z, Poorbaferani M, Safavi SM. Flaxseed oil supplementation on severity of depression and brain-derived neurotrophic factor: a randomized, double blind placebo controlled clinical trial. Int J Food Prop. 2020;23(1):1518–26.
  • Witte AV, Kerti L, Hermannstädter HM, Fiebach JB, Schreiber SJ, Schuchardt JP, et al. Long-chain omega-3 fatty acids improve brain function and structure in older adults. Cereb Cortex. 2014;24(11):3059–68.
  • Sugasini D, Yalagala PC, Subbaiah PV. Plasma BDNF is a more reliable biomarker than erythrocyte omega-3 index for the omega-3 fatty acid enrichment of brain. Sci Rep. 2020;10(1):10809.
  • Cardoso HD, dos Santos Junior EF, de Santana DF, Gonçalves-Pimentel C, Angelim MK, Isaac AR, et al. Omega-3 deficiency and neurodegeneration in the substantia nigra: involvement of increased nitric oxide production and reduced BDNF expression. Biochimica et Biophysica Acta (BBA)-General Subjects. 2014;1840(6):1902–12.
  • Dighriri IM, Alsubaie AM, Hakami FM, Hamithi DM, Alshekh MM, Khobrani FA, et al. Effects of omega-3 polyunsaturated fatty acids on brain functions: a systematic review. Cureus. 2022;14(10.
  • Welty FK. Omega-3 fatty acids and cognitive function. Curr Opin Lipidol. 2023;34(1):12–21.
  • Cutuli D, Pagani M, Caporali P, Galbusera A, Laricchiuta D, Foti F, et al. Effects of omega-3 fatty acid supplementation on cognitive functions and neural substrates: a voxel-based morphometry study in aged mice. Front Aging Neurosci. 2016;8:38.
  • Molendijk M, Van Tol M, Penninx B, Van der Wee N, Aleman A, Veltman D, et al. BDNF val66met affects hippocampal volume and emotion-related hippocampal memory activity. Transl Psychiatry. 2012;2(1):e74.
  • Benjamin S, McQuoid DR, Potter GG, Payne ME, MacFall JR, Steffens DC, et al. The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression. Am J Geriatr Psychiatry. 2010;18(4):323–31.
  • Cerasa A, Tongiorgi E, Fera F, Gioia MC, Valentino P, Liguori M, et al. The effects of BDNF Val66Met polymorphism on brain function in controls and patients with multiple sclerosis: an imaging genetic study. Behav Brain Res. 2010;207(2):377–86.
  • Berger M, Seemüller F, Voggt A, Obermeier M, Kirchberg F, Löw A, et al. Omega-3 fatty acids in bipolar patients with a low omega-3 index and reduced heart rate variability: the “BIPO-3” trial. Int J Bipolar Disord. 2022;10(1):1–11.
  • Bahadorpour S, Hajhashemy Z, Mohammadi S, Mokhtari E, Heidari Z, Saneei P. Total fat and omega-3 fatty acids intake in relation to serum brain-derived neurotrophic factor (BDNF) levels and psychological disorders in Iranian adults. Sci Rep. 2023;13(1):5392.
  • Paduchová Z, Katrenčíková B, Vaváková M, Laubertová L, Nagyová Z, Garaiova I, et al. The effect of omega-3 fatty acids on thromboxane, brain-derived neurotrophic factor, homocysteine, and vitamin D in depressive children and adolescents: randomized controlled trial. Nutrients. 2021;13(4):1095.
  • Bhat SA, Ara A. Omega-3 fatty acids and the treatment of depression: a review of scientific evidence. Integ Med Res. 2015;4(3):132–41.
  • Casanova E, Berger W, Brostjan C, Eferl R, Egger G, Heffeter P, et al. Gergely Szakacs, PhD.
  • Rogero MM, MdC L, Santana TM, de MB Pimentel MV, Carlini GC, da Silveira TF, et al. Potential benefits and risks of omega-3 fatty acids supplementation to patients with COVID-19. Free Radical Biol Med. 2020;156:190–9.
  • Lee Y-H, Bae S-C, Song G-G. Omega-3 polyunsaturated fatty acids and the treatment of rheumatoid arthritis: a meta-analysis. Arch Med Res. 2012;43(5):356–62.
  • Giannaccare G, Pellegrini M, Sebastiani S, Bernabei F, Roda M, Taroni L, et al. Efficacy of omega-3 fatty acid supplementation for treatment of dry eye disease: a meta-analysis of randomized clinical trials. Cornea. 2019;38(5):565–73.
  • Reimers A, Ljung H. The emerging role of omega-3 fatty acids as a therapeutic option in neuropsychiatric disorders. Ther Adv Psychopharmacol. 2019;9; doi:10.1177/2045125319858901.
  • Jackson KH, Polreis JM, Tintle NL, Kris-Etherton PM, Harris WS. Association of reported fish intake and supplementation status with the omega-3 index. Prostaglandins, Leukotrienes Essent Fatty Acids. 2019;142:4–10.
  • Harel Z, Gascon G, Riggs S, Vaz R, Brown W, Exil G. Supplementation with omega-3 polyunsaturated fatty acids in the management of recurrent migraines in adolescents. J Adoles Health. 2002;31(2):154–61.
  • Pu H, Guo Y, Zhang W, Huang L, Wang G, Liou AK, et al. Omega-3 polyunsaturated fatty acid supplementation improves neurologic recovery and attenuates white matter injury after experimental traumatic brain injury. J Cereb Blood Flow Metab. 2013;33(9):1474–84.

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