65
Views
9
CrossRef citations to date
0
Altmetric
Original Articles

7H-BENZO[C]FLUORENE: A POTENT SYSTEMIC LUNG CARCINOGEN

, , , , &
Pages 1-20 | Received 01 Aug 2003, Accepted 01 Sep 2003, Published online: 16 Aug 2010

REFERENCES

  • International Agency for Research on Cancer . 1984 . IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 34: Polycyclic Aromatic Compounds. Part 3. Industrial Exposures in Aluminum Production, Coal Gasification, Coke Production, and Iron and Steel Founding , Lyon, , France : IARC .
  • International Agency for Research on Cancer . 1985 . IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 35: Polycyclic Aromatic Compounds. Part 4. Bitumens, Coal-Tars and Derived Products, Shale-Oils and Soots , Lyon, , France : IARC .
  • U.S. Department of Health and Human Services . 1998 . Survey of Compounds which Have Been Tested for Carcinogenic Activity U.S. Public Health Service Publication No. 149 (original)
  • Robinson , M. , Laurie , R. D. , Bull , R. J. and Stober , J. A. 1987 . Carcinogenic Effects in A/J Mice of Particulate of a Coal Tar Paint Used in Potable Water Systems . Cancer Letters , 34 : 49 – 54 .
  • Weyand , E. H. , Chen , Y.-C. , Wu , Y. , Koganti , A. , Dunsford , H. A. and Rodriguez , L. V. 1995 . Differences in the Tumorigenic Activity of a Pure Hydrocarbon and a Complex Mixture Following Ingestion: Benzo[a]pyrene vs. Manufactured Gas Plant Residue . Chemical Research in Toxicology , 8 : 949 – 954 .
  • Rodriguez , L. V. , Dunsford , H. A. , Steinberg , M. , Chaloupka , K. K. , Zhu , L. , Safe , S. , Womack , E. and Goldstein , L. S. 1997 . Carcinogenicity of Benzo[a]pyrene and Manufactured Gas Plant Residues in Infant Mice . Carcinogenesis , 18 : 127 – 135 .
  • Culp , S. J. , Gaylor , D. W. , Sheldon , W. G. , Goldstein , L. S. and Beland , F. A. 1998 . A Comparison of the Tumors Induced by Coal Tar and Benzo[a]pyrene in a 2-Year Bioassay . Carcinogenesis , 19 : 117 – 124 .
  • Goldstein , L. S. , Safe , S. and Weyand , E. H. 1994 . Carcinogenicity of Coal Tars: A Multidisciplinary Approach . Polycyclic Aromatic Compounds , 7 : 161 – 174 .
  • Gaylor , D. W. , Culp , S. J. , Goldstein , L. S. and Beland , F. A. 2000 . Cancer Risk Estimation for Mixtures of Coal Tars and benzo(a)pyrene . Risk Analysis , 20 : 81 – 85 .
  • Koganti , A. , Singh , R. , Rozett , K. , Modi , N. , Goldstein , L. , Roy , T. , Zhang , F-J. , Harvey , R. and Weyand , E. H. 2000 . 7H-Benzo[c]fluorene: A Major DNA Adducting Component of Coal Tar . Carcinogenesis , 21 : 1601 – 1609 .
  • Levin , W. , Wood , A. W. , Chang , R. L. , Ittah , Y. , Croisy-Delcey , M. , Yagi , H. , Conney , A. H. and Jerina , D. M. 1980 . Exceptionally High Tumor-Initiating Activity of Benzo[c]-phenanthrene Bay-Region Diol-Epoxides on Mouse Skin . Cancer Research , 40 : 3910 – 3914 .
  • Einolf , H. J. , Amin , S. , Yagi , H. , Jerina , D. M. and Baird , W. M. 1996 . Benzo[c]Phenanthrene Is Activated to DNA-Binding Diol Epoxides in the Human Mammary Carcinoma Cell Line MCF-7 but Only Limited Activation Occurs in Mouse Skin . Carcinogenesis , 17 : 2237 – 2244 .
  • LaVoie , E. J. , Cai , Z. W. , Meschter , C. L. and Weyand , E. H. 1994 . Tumorigenic Activity of Fluoranthene, 2-Methylfluoranthene, and 3-Methylfluoranthene in Newborn CD-1 Mice . Carcinogenesis , 15 : 2131 – 2135 .
  • LaVoie , E. J. , Tulley-Freiler , L. , Bedenko , V. , Girach , Z. and Hoffmann , D. 1981 . “ Comparative Studies on the Tumor Initiating Activity and Metabolism of Methylfluorenes and Methylbenzofluorenes ” . In Chemical Analysis and Biological Fate: Polynuclear Aromatic Hydrocarbons , Edited by: Cooke , M. and Dennis , A. J. 417 – 427 . Columbus, Ohio : Battelle Press .
  • Bachmann , W. E. , Cook , J. W. , Dansi , A. , de Worms , C. G. M. , Haslewood , G. A. D. , Hewett , C. L. and Robinson , A. M. 1937 . “ The Production of Cancer by Pure Hydrocarbons: IV ” . In Proceedings Royal Society London 343 – 368 .
  • LaVoie , E. J. , Tulley , L. , Bedenko , V. and Hoffmann , D. 1981 . Mutagenicity of Methylated Fluorenes and Benzofluorenes . Mutation Research , 91 : 167 – 176 .
  • Weyand , E. H. , Wu , Y. , Patel , S. and Goldstein , L. 1994 . Biochemical Effects of Manufactured Gas Plant Residue Following Ingestion by B6C3F1 Mice . Journal of Toxicology and Environmental Health , 42 : 89 – 107 .
  • Weyand , E. H. and Wu , Y. 1995 . Covalent Binding of Polycyclic Aromatic Hydrocarbon Components of Manufactured Gas Plant Residue to Mouse Lung and Forestomach DNA . Chemical Research Toxicology , 8 : 955 – 962 .
  • Singh , R. , Kuber , N. , Espino , O. , Landmesser , E. , Harvey , R. G. and Weyand , E. H. 2001 . Evaluation of Skin and Lung DNA Adducts Following the Topical Administration of Benzo[c]fluorene, Benzo[a]pyrene, or Coal Tar . The Toxicologists , 60 : 1818
  • Koganti , A. , Singh , R. , Bing-Li , M. and Weyand , E. H. 2001 . Comparative Analysis of PAH: DNA Adducts Formed in Lung of Mice Fed Neat Coal Tar and Soils Contaminated with Coal Tar . Environmental Science and Technology , 35 : 2704 – 2709 .
  • Goth-Goldstein , R. , Russell , M. , Parimoo , B. and Weyand , E. H. 2002 . 7H-Benzo[c]fluorene DNA Adduct Formation in Different Human Cells in Culture . American Association of Cancer Research , 93 : 1719
  • Li , D. , Wang , M.-Y. , Firozi , P. F. , Chang , P. , Zhang , W. , Baer-Dubowska , W. , Bhagavatula , M. , Vulimiri , S. V. , Goth-Goldstein , R. , Weyand , E. H. and DiGiovanni , J. 2002 . Characterization of a Major Aromatic DNA Adduct Detected in Human Breast tissue . Environmental Molecular Mutagenesis , 39 : 193 – 200 .
  • Harvey , R. G. , Pataki , J , Cortez , C. , Di Raddo , P. and Yang , C. 1991 . A New General Synthesis of Polycyclic Aromatic Compounds Based on Enamine Chemistry . Journal of Organic Chemistry , 56 : 1210 – 1217 .
  • Harvey , R. H. , ed. 1997 . Polycyclic Aromatic Hydrocarbons , New York : Wiley-VCH .
  • Weyand , E. H. , Wu , Y. , Patel , S. , Taylor , B. B. and Mauro , D. M. 1991 . Urinary Excretion and DNA Binding of Coal Tar Components in B6C3F1 Mice Following Ingestion . Chemical Research in Toxicology , 4 : 466 – 473 .
  • Maronpot , R. R. , ed. 1999 . Pathology of the Mouse , Vienna, IL : Cache River .
  • Culp , S. J. , Warbritton , A. R. , Smith , B. A. , Li , E. E. and Beland , F. A. 2001 . DNA Adduct Measurements, Cell Proligeration and Tumor Mutation Induction in Relation to Tumor Formation in B6C3F1 Mice Fed Coal Tar or Benzo[a]pyrene . Carcinogenesis , 21 : 1433 – 1440 .
  • Stoner , G. D. , Greisiger , E. A. , Schut , H. A. , Pereira , M. A. , Loeb , T. R. , Klaunig , J. E. and Branstetter , D. G. 1984 . A Comparison of the Lung Adenoma Response in Strain A/J Mice after Intraperitoneal and Oral Administration of Carcinogens . Toxicological and Applied Pharmacology , 72 : 313 – 323 .
  • Parimoo , B. , Goldstein , L. S. , Wang , J. Q. , Harvey , R. G. and Weyand , E. H. 2002 . Studies on the Mechanism of Activation of Benzo[c]fluorene . The Toxicologists , 61 : 1485
  • Singh , R. and Weyand , E. H. 1994 . Studies on the Binding of Various Polycyclic Aromatic Hydrocarbons to Mouse Hemoglobin and Serum Proteins . Polycyclic Aromatic Compounds , 6 : 135 – 142 .
  • Weyand , E. H. , Cai , Z.-W. , Wu , Y. , Rice , J. E. , He , Z.-M. and LaVoie , E. J. 1993 . Detection of the Major DNA Adducts of Benzo[b]fluoranthene in Mouse Skin: Role of Phenolic Dihydrodiols . Chemical Research in Toxicology , 6 : 568 – 577 .
  • Gaylor , D. W. 1992 . Relationship between the Shape of Dose-Response Curves and Background Tumor Rates . Regulatory Toxicology and Pharmacology , 16 : 2 – 9 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.