Recent Update on the Pharmacological Significance of Isatis tinctoria L. (Brassicaceae) Extracts

References

• Royal Botanic Gardens, Kew: Medicinal Plant Names Services (n.d.). https://mpns.science.kew.org/mpns-portal/searchName? (accessed November 10, 2020).
   Google Scholar
• E. Poli Marchese, Piante e fiori dell’Etna (Palermo, Italy: Sellerio, 1991).
   Google Scholar
• D. Aichele, Che fiore è? Biblioteca (Milano, Italy: Universale Rizzoli, 1987).
   Google Scholar
• F. Branca, “Isatis tinctoria L.: An Ancient Dye Plant of Interest as a Multifunctional Crop,” Chronicles of Horticulture 55 (2015): 20–4.
   Google Scholar
• S.H. Buhner, Herbal Antivirals: Natural Remedies for Emerging, Resistant and Epidemic Viral Infections (North Adams, MA: Storey Publishing, 2013).
   Google Scholar
• C. Oberthür, R. Jäggi, and M. Hamburger, “HPLC Based Activity Profiling for 5-Lipoxygenase Inhibitory Activity in Isatis Tinctoria Leaf Extracts,” Fitoterapia 76, no. 3/4 (2005): 324–32..
   PubMed Web of Science ®Google Scholar
• L.M. Perry, Medicinal Plants of East and Southeast Asia: Attributed Properties and Uses (Cambridge, UK: MIT Press, 1980).
   Google Scholar
• Y.-P. Zhu, Chinese Materia Medica: Chemistry, Phamacology and Applications (Amsterdam, The Netherlands: Harwood Academic Publishers, 1998).
   Google Scholar
• M.-C. Recio, M. Cerdá-Nicolás, O. Potterat, M. Hamburger, and J.-L. Ríos, “Anti-Inflammatory and Antiallergic Activity in Vivo of Lipophilic Isatis Tinctoria Extracts and Tryptanthrin,” Planta Medica 72no. 6 (2006): 539–46..
   PubMed Web of Science ®Google Scholar
• M. Hamburger, “Isatis Tinctoria – from the Rediscovery of an Ancient Medicinal Plant towards a Novel anti-Inflammatory Phytopharmaceutical,” Phytochemistry Reviews 1, no. 3 (2002): 333–44..
   Google Scholar
• “Redeploying Plant Defences Editorial,” Nature Plants 6 (2020): 177.
   PubMed Web of Science ®Google Scholar
• J. Speranza, N. Miceli, M. F. Taviano, S. Ragusa, I. Kwiecień, A. Szopa, and H. Ekiert, “Isatis Tinctoria L. (Woad): a Review of Its Botany, Ethnobotanical Uses, Phytochemistry, Biological Activities, and Biotechnological Studies,” Plants 9, no. 3 (2020): 298..
   Google Scholar
• N. Courtin, A. F. Fotso, P. Fautrad, F. Mas, M.-C. Alessi, and B. Riteau, “Antiviral Activity of Formyl Peptide Receptor 2 Antagonists against Influenza Viruses,” Antiviral Research 143 (2017): 252–61..
   PubMed Web of Science ®Google Scholar
• W. Tao, B. L. Hurst, A. K. Shakya, M. J. Uddin, R. S. J. Ingrole, M. Hernandez-Sanabria, R. P. Arya, L. Bimler, S. Paust, E. B. Tarbet, et al. “Consensus M2e Peptide Conjugated to Gold Nanoparticles Confers Protection against H1N1, H3N2 and H5N1 Influenza a Viruses,” Antiviral Research 141 (2017): 62–72..
   PubMed Web of Science ®Google Scholar
• V. V. Zarubaev, A. V. Garshinina, T. S. Tretiak, V. A. Fedorova, A. A. Shtro, A. S. Sokolova, O. I. Yarovaya, and N. F. Salakhutdinov, “Broad Range of Inhibiting Action of Novel Camphor-Based Compound with anti-Hemagglutinin Activity against Influenza Viruses in Vitro and in Vivo,”Antiviral Research 120 (2015): 126–33..
   PubMed Web of Science ®Google Scholar
• V. Correia, L. A. Santos, M. Gíria, M. M. Almeida-Santos, and H. Rebelo-de-Andrade, “Influenza A(H1N1)pdm09 Resistance and Cross-Decreased Susceptibility to Oseltamivir and Zanamivir Antiviral Drugs,” Journal of Medical Virology 87, no. 1 (2015): 45–55..
   PubMed Web of Science ®Google Scholar
• F. G. Hayden, and M. D. de Jong, “Emerging Influenza Antiviral Resistance Threats,” The Journal of Infectious Diseases 203, no. 1 (2011): 6–10..
   PubMed Web of Science ®Google Scholar
• T. Wang, X. Wang, Y. Zhuo, C. Si, L. Yang, L. Meng, and B. Zhu, “Antiviral Activity of a Polysaccharide from Radix Isatidis (Isatis Indigotica Fortune) against Hepatitis B Virus (HBV) in Vitro via Activation of JAK/STAT Signal Pathway,” Journal of Ethnopharmacology 257 (2020): 112782..
   PubMed Web of Science ®Google Scholar
• L. Ke, T. Wen, J. P. Bradshaw, J. Zhou, and P. Rao, “Antiviral Decoction of Isatidis Radix (板藍根 Bǎn Lán Gēn) Inhibited Influenza Virus Adsorption on MDCK Cells by Cytoprotective Activity,” Journal of Traditional and Complementary Medicine 2, no. 1 (2012): 47–51..
   PubMedGoogle Scholar
• H. Xu, L. He, J. Chen, X. Hou, F. Fan, H. Wu, H. Zhu, and Y. Guo, “Different Types of Effective Fractions from Radix Isatidis Revealed a Multiple-target Synergy Effect Against Respiratory Syncytial Virus Through RIG-I and MDA5 Signaling Pathways, a Pilot Study to Testify the Theory of Superposition of Traditional Chinese Medicine Efficacy,” J Ethnopharmacol 239 (2019): 111901..
   PubMed Web of Science ®Google Scholar
• N.-K. Mak, C.-Y. Leung, X.-Y. Wei, X.-L. Shen, R. N.-S. Wong, K.-N. Leung, and M.-C. Fung, “Inhibition of RANTES Expression by Indirubin in Influenza Virus-infected Human Bronchial Epithelial Cells ,” Biochemical Pharmacology 67, no. 1 (2004): 167–74..
   PubMed Web of Science ®Google Scholar
• Z. Shi-Jing, L. Ming-Hua, L. Han-Bing, J. Li, L. Ying, and S. Qin, “In Vitro anti-Viral Effects and Dose-Effect Relationship of Epigoitrin and Fructopyrano-(1→4)-Glucopyranose Based on Deletion/Increment Strategy,” Chinese Journal of New Drugs 22 (2013): 1083–7.
   Google Scholar
• Z. Yang, Y. Wang, Z. Zheng, S. Zhao, J. Zhao, Q. Lin, C. Li, Q. Zhu, and N. Zhong, “Antiviral Activity of Isatis Indigotica Root-Derived Clemastanin B against Human and Avian Influenza a and B Viruses in Vitro,”International Journal of Molecular Medicine 31, no. 4 (2013): 867–73..
   PubMed Web of Science ®Google Scholar
• J. Li, B. Zhou, C. Li, Q. Chen, Y. Wang, Z. Li, T. Chen, C. Yang, Z. Jiang, N. Zhong, et al. “Lariciresinol-4-O-β-D-Glucopyranoside from the Root of Isatis Indigotica Inhibits Influenza a Virus-Induced Pro-Inflammatory Response,” Journal of Ethnopharmacology 174 (2015) : 379–86..
   PubMed Web of Science ®Google Scholar
• Z. Li, L. Li, H. Zhou, L. Zeng, T. Chen, Q. Chen, B. Zhou, Y. Wang, Q. Chen, P. Hu, et al. “Radix Isatidis Polysaccharides Inhibit Influenza a Virus and Influenza a Virus-Induced Inflammation via Suppression of Host TLR3 Signaling in Vitro,” Molecules 22, no. 1 (2017): 116..
   Web of Science ®Google Scholar
• Q. Guo, C. Xu, M. Chen, S. Lin, Y. Li, C. Zhu, J. Jiang, Y. Yang, and J. Shi, “Sulfur-Enriched Alkaloids from the Root of Isatis Indigotica,” Acta Pharmaceutica Sinica B 8, no. 6 (2018): 933–43..
   PubMed Web of Science ®Google Scholar
• L. Nie, Y. Wu, Z. Dai, and S. Ma, “Antiviral Activity of Isatidis Radix Derived Glucosinolate Isomers and Their Breakdown Products Against Influenza A in Vitro/Ovo and Mechanism of Action,” Journal of Ethnopharmacology 251 (2020): 112550..
   PubMed Web of Science ®Google Scholar
• M. Chen, S. Lin, L. Li, C. Zhu, X. Wang, Y. Wang, B. Jiang, S. Wang, Y. Li, J. Jiang, et al. “Enantiomers of an Indole Alkaloid Containing Unusual Dihydrothiopyran and 1,2,4-Thiadiazole Rings from the Root of Isatis indigotica,” Organic Letters 14, no. 22 (2012): 5668–71..
   PubMed Web of Science ®Google Scholar
• X.-L. Wang, M.-H. Chen, F. Wang, P.-B. Bu, S. Lin, C.-G. Zhu, Y.-H. Li, J.-D. Jiang, and J.-G. Shi, “Chemical Constituents from Root of Isatis Indigotica,” Zhongguo Zhong Yao za Zhi = Zhongguo Zhongyao Zazhi [China Journal of Chinese Materia Medica] 38, no. 8 (2013): 1172–82. http://europepmc.org/abstract/MED/23944031.
   PubMedGoogle Scholar
• Y.-F. Liu, M.-H. Chen, Q.-L. Guo, S. Lin, C.-B. Xu, Y.-P. Jiang, Y.-H. Li, J.-D. Jiang, and J.-G. Shi, “Antiviral Glycosidic Bisindole Alkaloids from the Roots of Isatis Indigotica,”Journal of Asian Natural Products Research 17, no. 7 (2015): 689–704..
   PubMed Web of Science ®Google Scholar
• Y. Liu, M. Chen, Q. Guo, Y. Li, J. Jiang, and J. Shi, “Aromatic Compounds from an Aqueous Extract of “ "ban lan gen" and Their Antiviral Activities,” Acta Pharmaceutica Sinica B 7, no. 2 (2017): 179–84..
   PubMed Web of Science ®Google Scholar
• M.-H. Chen, S. Lin, Y.-N. Wang, C.-G. Zhu, Y.-H. Li, J.-D. Jiang, and J.-G. Shi, “Antiviral Stereoisomers of 3,5-Bis(2-Hydroxybut-3-en-1-yl)-1,2,4-Thiadiazole from the Roots of Isatis Indigotica,” Chinese Chemical Letters 27, no. 5 (2016): 643–8..
   Web of Science ®Google Scholar
• L.-J. Meng, Q.-L. Guo, C.-B. Xu, C.-G. Zhu, Y.-F. Liu, M.-H. Chen, S. Lin, Y.-H. Li, J.-D. Jiang, and J.-G. Shi, “Diglycosidic Indole Alkaloid Derivatives from an Aqueous Extract of Isatis Indigotica Roots,” Journal of Asian Natural Products Research 19, no. 6 (2017): 529–40..
   PubMed Web of Science ®Google Scholar
• X. Liang, Y. Huang, X. Pan, Y. Hao, X. Chen, H. Jiang, J. Li, B. Zhou, and Z. Yang, “Erucic Acid from Isatis indigotica Fort. Suppresses Influenza a Virus Replication and Inflammation In Vitro and In Vivo Through Modulation of NF-κB and p38 MAPK Pathway,” Journal of Pharmaceutical Analysis 10, no. 2 (2020): 130–46..
   PubMed Web of Science ®Google Scholar
• C. Jie, Z. Luo, H. Chen, M. Wang, C. Yan, Z.-F. Mao, G.-K. Xiao, H. Kurihara, Y.-F. Li, and R.-R. He, “Indirubin, a Bisindole Alkaloid from Isatis indigotica, Reduces H1N1 Susceptibility in Stressed Mice by Regulating MAVS Signaling,” Oncotarget 8, no. 62 (2017): 105615–10629..
   PubMedGoogle Scholar
• Y.-F. Liu, M.-H. Chen, S. Lin, Y.-H. Li, D. Zhang, J.-D. Jiang, and J.-G. Shi, “Indole Alkaloid Glucosides from the Roots of Isatis indigotica,” Journal of Asian Natural Products Research 18, no. 1 (2016): 1–12..
   PubMed Web of Science ®Google Scholar
• L. Meng, Q. Guo, Y. Liu, M. Chen, Y. Li, J. Jiang, and J. Shi, “Indole Alkaloid Sulfonic Acids from an Aqueous Extract of Isatis indigotica Roots and Their Antiviral Activity,” Acta Pharmaceutica Sinica B 7, no. 3 (2017): 334–41..
   PubMed Web of Science ®Google Scholar
• L. Meng, Q. Guo, M. Chen, J. Jiang, Y. Li, and J. Shi, “Isatindolignanoside A, a Glucosidic Indole-Lignan Conjugate from an Aqueous Extract of the Isatis indigotica Roots,” Chinese Chemical Letters 29, no. 8 (2018): 1257–60..
   Web of Science ®Google Scholar
• D.-W. Li, Q.-L. Guo, X.-H. Meng, C.-G. Zhu, C.-B. Xu, and J.-G. Shi, “Two Pairs of Unusual Scalemic Enantiomers from Isatis indigotica Leaves,” Chinese Chemical Letters 27, no. 12 (2016): 1745–50..
   Web of Science ®Google Scholar
• C. Xu, Y. Xin, M. Chen, M. Ba, Q. Guo, C. Zhu, Y. Guo, and J. Shi, “Discovery, Synthesis, and Optimization of an N-Alkoxy Indolylacetamide against HIV-1 Carrying NNRTI-Resistant Mutations from the Isatis indigotica Root,” European Journal of Medicinal Chemistry 189 (2020): 112071..
   PubMed Web of Science ®Google Scholar
• L.-J. Meng, Q.-L. Guo, C.-G. Zhu, C.-B. Xu, and J.-G. Shi, “Isatindigodiphindoside, an Alkaloid Glycoside with a New Diphenylpropylindole Skeleton from the Root of Isatis indigotica,” Chinese Chemical Letters 29, no. 1 (2018): 119–22..
   Web of Science ®Google Scholar
• V. Wai, C. Wong, and E. Lerner, “Nitric Oxide Inhibition Strategies,” Future Science OA 1, no. 1 (2015): FS035..
   Web of Science ®Google Scholar
• R. G. Knowles, M. Palacios, R. M. Palmer, and S. Moncada, “Formation of Nitric Oxide from L-arginine in the Central Nervous System: A Transduction Mechanism for Stimulation of the Soluble Guanylate Cyclase ,”Proceedings of the National Academy of Sciences of the United States of America 86, no. 13 (1989): 5159–62..
   PubMed Web of Science ®Google Scholar
• D. Bruch-Gerharz, T. Ruzicka, and V. Kolb-Bachofen, “Nitric Oxide in Human Skin: Current Status and Future Prospects,” The Journal of Investigative Dermatology 110, no. 1 (1998): 1–7..
   PubMed Web of Science ®Google Scholar
• A. A. Qureshi, L. H. Lerner, and E. A. Lerner, “From Bedside to the Bench and Back,” Archives of Dermatology 132, no. 8 (1996): 889–93..
   PubMedGoogle Scholar
• J. Olesen, and M. Ashina, “Emerging Migraine Treatments and Drug Targets,” Trends in Pharmacological Sciences 32, no. 6 (2011): 352–9..
   PubMed Web of Science ®Google Scholar
• N. Li, H. Worthmann, M. Deb, S. Chen, and K. Weissenborn, “Nitric Oxide (NO) and Asymmetric Dimethylarginine (ADMA): Their Pathophysiological Role and Involvement in Intracerebral Hemorrhage,” Neurological Research 33, no. 5 (2011): 541–8..
   PubMed Web of Science ®Google Scholar
• E. Bonfoco, D. Krainc, M. Ankarcrona, P. Nicotera, and S. A. Lipton, “Apoptosis and Necrosis: two Distinct Events Induced, Respectively, by Mild and Intense Insults with N-methyl-D-Aspartate or Nitric Oxide/Superoxide in Cortical Cell Cultures,” Proceedings of the National Academy of Sciences of the United States of America 92no. 16 (1995): 7162–6..
   PubMed Web of Science ®Google Scholar
• L. C. Jadeski, K. O. Hum, C. Chakraborty, and P. K. Lala, “Nitric Oxide Promotes Murine Mammary Tumour Growth and Metastasis by Stimulating Tumour Cell Migration, Invasiveness and Angiogenesis,” International Journal of Cancer 86, no. 1 (2000): 30–9..
   PubMed Web of Science ®Google Scholar
• D. Zhang, Y. Shi, R. Xu, K. Du, F. Guo, K. Chen, Y. Li, and R. Wang, “Alkaloid Enantiomers from the Roots of Isatis indigotica,” Molecules 24, no. 17 (2019): 3140..
   Web of Science ®Google Scholar
• D. Zhang, J. Li, D. Ruan, Z. Chen, W. Zhu, Y. Shi, K. Chen, Y. Li, and R. Wang, “Lignans from Isatis indigotica Roots and Their Inhibitory Effects on Nitric Oxide Production,” Fitoterapia 137, (2019) : 104189undefined..
   PubMed Web of Science ®Google Scholar
• D. Zhang, Y. Sun, D. Ruan, J. Li, K. Chen, Y. Li, and R. Wang, “Three New Indole Alkaloid Glycosides with Unusual Structural Features from the Roots of Isatis indigotica,” Phytochemistry Letters 39 (2020): 168–72..
   Web of Science ®Google Scholar
• D. Zhang, Y. Sun, Z. Chen, Q. Jia, W. Zhu, K. Chen, Y. Li, and R. Wang, “Bisindole Alkaloids with Nitric Oxide Inhibitory Activities from an Alcohol Extract of the Isatis indigotica Roots,” Fitoterapia 146 (2020): 104654..
   PubMed Web of Science ®Google Scholar
• R. J. Casson, G. Chidlow, A. Ebneter, J. P. Wood, J. Crowston, and I. Goldberg, “Translational Neuroprotection Research in Glaucoma: A Review of Definitions and Principles,” Clinical & Experimental Ophthalmology 40, no. 4 (2012): 350–7..
   PubMed Web of Science ®Google Scholar
• S. E. Seidl, and J. A. Potashkin, “The Promise of Neuroprotective Agents in Parkinson?s Disease,” Frontiers in Neurology 2 (2011): 68..
   PubMedGoogle Scholar
• S. B. Dunnett, and A. Björklund, “Prospects for New Restorative and Neuroprotective Treatments in Parkinson's disease,” Nature 399, no. 6738 (1999): A32–A39..
   PubMed Web of Science ®Google Scholar
• J. K. Andersen, “Oxidative Stress in Neurodegeneration: cause or Consequence?,” Nature Medicine 10, no. S7 (2004): S18–S25..
   PubMed Web of Science ®Google Scholar
• D. Zádori, P. Klivényi, L. Szalárdy, F. Fülöp, J. Toldi, and L. Vécsei, “Mitochondrial Disturbances, Excitotoxicity, Neuroinflammation and Kynurenines: Novel Therapeutic Strategies for Neurodegenerative Disorders,” Journal of the Neurological Sciences 322, no. 1/2 (2012): 187–91..
   PubMed Web of Science ®Google Scholar
• S.-F. Liu, Y.-Y. Zhang, L. Zhou, B. Lin, X.-X. Huang, X.-B. Wang, and S.-J. Song, “Alkaloids with Neuroprotective Effects from the Leaves of Isatis indigotica Collected in the Anhui Province, China,” Phytochemistry 149 (2018): 132–9..
   PubMed Web of Science ®Google Scholar
• Y.-F. Xi, S.-F. Liu, W. Hong, X.-Y. Song, L.-L. Lou, L. Zhou, G.-D. Yao, B. Lin, X.-B. Wang, X.-X. Huang, et al. “Discovery of Cycloneolignan Enantiomers from Isatis indigotica Fortune with Neuroprotective Effects Against MPP+-Induced SH-SY5Y Cell Injury,” Bioorganic Chemistry 88 (2019): 102926..
   PubMed Web of Science ®Google Scholar
• Y.-F. Xi, L.-L. Lou, F.-Y. Han, S.-F. Liu, G.-D. Yao, B. Lin, X.-X. Huang, X.-B. Wang, and S.-J. Song, “Four Pairs of Alkaloid Enantiomers from Isatis indigotica Fortune Ex Land with Neuroprotective Effects against H2O2-induced SH-SY5Y cell injury,” Bioorganic Chemistry 96 (2020): 103650..
   PubMed Web of Science ®Google Scholar
• Y.-F. Xi, L. Zhou, M. Bai, J. Wang, B. Lin, X.-B. Wang, X.-X. Huang, and S.-J. Song, “ N-Acylanthranilic Acid Derivatives with Anti-Aβ1-42 Aggregation Activity from the Leaves of Isatis indigotica Fortune ,” Fitoterapia 128 (2018) : 169–74..
   PubMed Web of Science ®Google Scholar
• H. Mori, K. Ishii, T. Tomiyama, Y. Furiya, N. Sahara, S. Asano, N. Endo, T. Shirasawa, and K. Takio, “Racemization: Its Biological Significance on Neuropathogenesis of Alzheimer's Disease,” The Tohoku Journal of Experimental Medicine 174, no. 3 (1994): 251–62..
   PubMed Web of Science ®Google Scholar
• Y. Wu, Z.-X. Zhang, H. Hu, D. Li, G. Qiu, X. Hu, and X. He, “Novel Indole C-Glycosides from Isatis indigotica and Their Potential Cytotoxic Activity,” Fitoterapia 82, no. 2 (2011): 288–92..
   PubMed Web of Science ®Google Scholar
• E. Kim, H. J. Ko, S. J. Jeon, S. Lee, H. E. Lee, H. N. Kim, E.-R. Woo, and J. H. Ryu, “The Memory-Enhancing Effect of Erucic Acid on Scopolamine-Induced Cognitive Impairment in Mice,” Pharmacology, Biochemistry, and Behavior 142 (2016): 85–96..
   PubMed Web of Science ®Google Scholar
• G. Zhao, T. Li, X. Qu, N. Zhang, M. Lu, and J. Wang, “Optimization of Ultrasound-Assisted Extraction of Indigo and Indirubin from Isatis indigotica Fort and Their Antioxidant Capacities,” Food Science and Biotechnology 26, no. 5 (2017): 1313–23..
   PubMed Web of Science ®Google Scholar
• M. F. Taviano, A. Filocamo, S. Ragusa, F. Cacciola, P. Dugo, L. Mondello, G. Paterniti Mastrazzo, R. F. de Rose, M. Celano, G. E. Lombardo, et al. “Phenolic Profile, Antioxidant and Cytotoxic Properties of Polar Extracts from Leaves and Flowers of Isatis Tinctoria L. (Brassicaceae) Growing in Sicily,” Plant Biosystems – An International Journal Dealing with All Aspects of Plant Biology 152, no. 4 (2018): 795–803..activity an organic process that takes place in the body More (Definitions, Synonyms, Translation)
   Web of Science ®Google Scholar