Synthesis of New Biological Functionalized Tetra Pyrimidodipyrimidines and Tetra Barbituric Moiety Conation Ether Groups

References

• G. B. Kauffman, “Adolf Von Baeyer and the Naming of Barbituric Acid,” Journal of Chemical Education 57, no. 3 (1980): 222–23.
   Web of Science ®Google Scholar
• K. T. Mahmudov, M. N. Kopylovich, A. M. Maharramov, M. M. Kurbanova, A. V. Gurbanov, and A. J. Pombeiro, “Barbituric Acids as a Useful Tool for the Construction of Coordination and Supramolecular Compounds,” Coordination Chemistry Reviews 265 (2014): 1–37.
   Web of Science ®Google Scholar
• K. T. Mahmudov, M. F. C. G. da Silva, M. N. Kopylovich, A. R. Fernandes, A. Silva, A. Mizar, and A. J. Pombeiro, “Di-and Tri-Organotin (IV) Complexes of Arylhydrazones of Methylene Active Compounds and Their Antiproliferative Activity,” Journal of Organometallic Chemistry 760 (2014): 67–73.
   Web of Science ®Google Scholar
• R. P. Rodrigues, S. F. Andrade, S. P. Mantoani, V. L. Eifler-Lima, V. B. Silva, and D. F. Kawano, “Using Free Computational Resources to Illustrate the Drug Design Process in an Undergraduate Medicinal Chemistry Course,” Journal of Chemical Education 92, no. 5 (2015): 827–35.
   Web of Science ®Google Scholar
• M. A. Bigdeli, E. Sheikhhosseini, A. Habibi, and S. Balalaie, “An Experimental Study of Special Leaving Group Behavior in the Reaction of Arylidenebarbituric Acids with Carbon Nucleophiles,” Heterocycles 83, no. 1 (2011): 107–16.
   Web of Science ®Google Scholar
• M. Faryabi and E. Sheikhhosseini, “Efficient Synthesis of Novel Benzylidene Barbituric and Thiobarbituric Acid Derivatives Containing Ethyleneglycol Spacers,” Journal of the Iranian Chemical Society 12, no. 3 (2015): 427–32.
   Web of Science ®Google Scholar
• E. Sheikhhosseini, “Design and Effective Synthesis of Novel Furo[2,3-d] Pyrimidine Derivatives Containing Ethylene Ether Spacers,” Journal of Saudi Chemical Society 22, no. 3 (2018): 337–42.
   Web of Science ®Google Scholar
• W. Doran, “Barbituric Acid Hypnotics,” Medicinal Chemistry 4 (1959): 164–67.
   Google Scholar
• J. Bojarski, J. L. Mokrosz, H. J. Bartoń, and M. H. Paluchowska, “Recent Progress in Barbituric Acid Chemistry,” Advances in Heterocyclic Chemistry 38 (1985): 229–97.
   Web of Science ®Google Scholar
• A. Barakat, M. S. Islam, A. M. Al-Majid, H. A. Ghabbour, S. Yousuf, M. Ashraf, N. N. Shaikh, M. I. Choudhary, R. Khalil, and Z. Ul-Haq, “Synthesis of Pyrimidine-2,4,6-Trione Derivatives: Anti-oxidant, Anti-cancer, α-glucosidase, β-Glucuronidase Inhibition and Their Molecular Docking Studies,” Bioorganic Chemistry 68 (2016): 72–79.
   PubMed Web of Science ®Google Scholar
• W. Chen, J. Feng, and H. Tu, “Synthesis and Antitumor Activities of Novel 2-Substituted Pyrimidinone-5-Carboxylic Acid Benzylamides,” Frontiers of Chemistry in China 2, no. 2 (2007): 127–30.
   Google Scholar
• A. Barakat, H. J. Al-Najjar, A. M. Al-Majid, S. M. Soliman, Y. N. Mabkhot, H. A. Ghabbour, and H.-K. Fun, “Synthesis and Molecular Characterization of 5,5′-((2,4-Dichlorophenyl)Methylene) Bis(1,3-Dimethylpyrimidine-2,4,6(1H,3H,5H)-Trione),” Journal of Molecular Structure 1084 (2015): 207–15.
   Web of Science ®Google Scholar
• C. Uhlmann and W. Fröscher, “Low Risk of Development of Substance Dependence for Barbiturates and Clobazam Prescribed as Antiepileptic Drugs: results from a Questionnaire Study,” CNS Neuroscience & Therapeutics 15, no. 1 (2009): 24–31.
   PubMed Web of Science ®Google Scholar
• F. Grams, H. Brandstetter, S. D'Alò, D. Geppert, H. W. Krell, H. Leinert, V. Livi, E. Menta, A. Oliva, G. Zimmermann, et al. “ Pyrimidine-2,4,6-Triones: A New Effective and Selective Class of Matrix Metalloproteinase Inhibitors,” Biological Chemistry 382, no. 8 (2001): 1277–85.
   PubMed Web of Science ®Google Scholar
• E. Milanesi, P. Costantini, A. Gambalunga, R. Colonna, V. Petronilli, A. Cabrelle, G. Semenzato, A. M. Cesura, E. Pinard, and P. Bernardi, “The Mitochondrial Effects of Small Organic Ligands of BCL-2: Sensitization of BCL-2-Overexpressing Cells to Apoptosis by a Pyrimidine-2,4,6-Trione Derivative,” The Journal of Biological Chemistry 281, no. 15 (2006): 10066–72.
   PubMed Web of Science ®Google Scholar
• Q. Tang, G. Zhang, X. Du, W. Zhu, R. Li, H. Lin, P. Li, M. Cheng, P. Gong, and Y. Zhao, “Discovery of Novel 6,7-Disubstituted-4-Phenoxyquinoline Derivatives Bearing 5-(Aminomethylene)Pyrimidine-2,4,6-Trione Moiety as c-Met Kinase Inhibitors,” Bioorganic & Medicinal Chemistry 22, no. 4 (2014): 1236–49.
   PubMed Web of Science ®Google Scholar
• A. Barakat, S. M. Soliman, A. M. Al-Majid, G. Lotfy, H. A. Ghabbour, H.-K. Fun, S. Yousuf, M. I. Choudhary, and A. Wadood, “Synthesis and Structure Investigation of Novel Pyrimidine-2, 4, 6-Trione Derivatives of Highly Potential Biological Activity as Anti-Diabetic Agent,” Journal of Molecular Structure 1098 (2015): 365–76.
   Web of Science ®Google Scholar
• A. Barakat, M. Ali, A. M. Al-Majid, S. Yousuf, M. I. Choudhary, R. Khalil, and Z. Ul-Haq, “Synthesis of Thiobarbituric Acid Derivatives: In Vitro α-Glucosidase Inhibition and Molecular Docking Studies,” Bioorganic Chemistry 75 (2017): 99–105.
   PubMed Web of Science ®Google Scholar
• M. Mohsenimehr, M. Mamaghani, F. Shirini, M. Sheykhan, and F. A. Moghaddam, “One-Pot Synthesis of Novel Pyrido [2,3-d] Pyrimidines Using HAp-Encapsulated-γ-Fe2O3 Supported Sulfonic Acid Nanocatalyst under Solvent-Free Conditions,” Chinese Chemical Letters 25, no. 10 (2014): 1387–91.
   Web of Science ®Google Scholar
• L. Yang, D. Shi, S. Chen, H. Chai, D. Huang, Q. Zhang, and J. Li, “Microwave-Assisted Synthesis of 2,3-Dihydropyrido[2,3-d]Pyrimidin-4 (1 H)-Ones Catalyzed by DBU in Aqueous Medium,” Green Chemistry 14, no. 4 (2012): 945–51.
   Web of Science ®Google Scholar
• M. Dabiri, H. Arvin-Nezhad, H. R. Khavasi, and A. Bazgir, “A Novel and Efficient Synthesis of Pyrimido[4,5-d]Pyrimidine-2,4,7-Trione and Pyrido[2,3-d:6,5-d] Dipyrimidine-2,4,6,8-Tetrone Derivatives,” Tetrahedron 63, no. 8 (2007): 1770–74.
   Web of Science ®Google Scholar
• A. Bazgir, M. M. Khanaposhtani, R. Ghahremanzadeh, and A. A. Soorki, “A Clean, Three-Component and One-Pot Cyclo-Condensation to Pyrimidine-Fused Heterocycles,” Comptes Rendus Chimie 12, no. 12 (2009): 1287–95.
   Web of Science ®Google Scholar
• H. Saeidiroshan and L. Moradi, “Immobilization of Cu (II) on MWCNTs@ L-His as a New High Efficient Reusable Catalyst for the Synthesis of Pyrido[2,3-d:5,6-d′] Dipyrimidine Derivatives,” Journal of Organometallic Chemistry 893 (2019): 1–10.
   Web of Science ®Google Scholar
• Lucía Cordeu, Elena Cubedo, Eva Bandrés, Amaia Rebollo, Xabi Sáenz, Hector Chozas, Ma Victoria Domínguez, Mikel Echeverría, Beatriz Mendivil, Carmen Sanmartin, et al. “Biological Profile of New Apoptotic Agents Based on 2,4-Pyrido[2,3-d]Pyrimidine Derivatives,” Bioorganic & Medicinal Chemistry 15, no. 4 (2007): 1659–69.
   PubMed Web of Science ®Google Scholar
• A. Kohzadian and A. Zare, “Effective and Rapid Synthesis of Pyrido[2, 3-d:6,5-d′] Dipyrimidines Catalyzed by a Mesoporous Recoverable Silica-Based Nanomaterial,” Silicon 12, no. 6 (2020): 1407–15.
   Web of Science ®Google Scholar
• C. Verma, M. A. Quraishi, K. Kluza, M. Makowska-Janusik, L. O. Olasunkanmi, and E. E. Ebenso, “Corrosion Inhibition of Mild Steel in 1M HCl by D-Glucose Derivatives of Dihydropyrido [2,3-d:6,5-d′] Dipyrimidine-2,4,6,8(1H,3H,5H,7H)-Tetraone,” Scientific Reports 7, no. 1 (2017): 44432.
   PubMedGoogle Scholar
• M. N. Nasr and M. M. Gineinah, “Pyrido[2,3‐d] Pyrimidines and Pyrimido[5′,4′:5,6]Pyrido[2,3‐d] Pyrimidines as New Antiviral Agents: synthesis and Biological Activity,” Archiv der Pharmazie 335, no. 6 (2002): 289–95.
   PubMed Web of Science ®Google Scholar
• T. Nagamatsu, H. Yamato, M. Ono, S. Takarada, and F. Yoneda, “Autorecycling Oxidation of Alcohols Catalysed by Pyridodipyrimidines as an NAD (P)+ Model,” Journal of the Chemical Society, Perkin Transactions 1 16, no. 16 (1992): 2101–09.
   Google Scholar
• H. Naeimi, A. Didar, Z. Rashid, and Z. Zahraie, “Sonochemical Synthesis of Pyrido[2,3-d:6,5-d′]-Dipyrimidines Catalyzed by [HNMP] + [HSO4]- and Their Antimicrobial Activity Studies,” The Journal of Antibiotics 70, no. 7 (2017): 845–52.
   PubMedGoogle Scholar
• P. M. Petersen, W. Wu, E. E. Fenlon, S. Kim, and S. C. Zimmerman, “Synthesis of Heterocycles Containing Two Cytosine or Two Guanine Base-Pairing Sites. Novel Tectons for Self-Assembly,” Bioorganic & Medicinal Chemistry 4, no. 7 (1996): 1107–12.
   PubMed Web of Science ®Google Scholar
• M. I. Choudhary and W. J. Thomsen, Bioassay Techniques for Drug Development (Taylor & Francis, 2001).
   Google Scholar
• C. G. Silva, R. S. Herdeiro, C. J. Mathias, A. D. Panek, C. S. Silveira, V. P. Rodrigues, M. N. Rennó, D. Q. Falcão, D. M. Cerqueira, A. B. M. Minto, et al. “Evaluation of Antioxidant Activity of Brazilian Plants,” Pharmacological Research 52, no. 3 (2005): 229–33.
   PubMed Web of Science ®Google Scholar
• C. Alasalvar, M. Karamać, R. Amarowicz, and F. Shahidi, “Antioxidant and Antiradical Activities in Extracts of Hazelnut Kernel (Corylus avellana L.) and Hazelnut Green Leafy Cover,” Journal of Agricultural and Food Chemistry 54, no. 13 (2006): 4826–32.
   PubMed Web of Science ®Google Scholar
• P. Molyneux, “The Use of the Stable Free Radical Diphenylpicrylhydrazyl (DPPH) for Estimating Antioxidant Activity,” Songklanakarin Journal of Science and Technology 26, no. 2 (2004): 211–19.
   Google Scholar
• M. Korycka-Dahl and T. Richardson, “Photogeneration of Superoxide Anion in Serum of Bovine Milk and in Model Systems Containing Riboflavin and Amino Acids,” Journal of Dairy Science 61, no. 4 (1978): 400–07.
   Web of Science ®Google Scholar
• Hakan Ozer, Münevver Sökmen, Medine Güllüce, Ahmet Adigüzel, Fikrettin Sahin, Atalay Sökmen, Hamdullah Kiliç, and Ozlem Baris, “Chemical Composition and Antimicrobial and Antioxidant Activities of the Essential Oil and Methanol Extract of Hippomarathrum microcarpum (Bieb.) from Turkey,” Journal of Agricultural and Food Chemistry 55, no. 3 (2007): 937–42.
   PubMed Web of Science ®Google Scholar
• A. A. P. Almeida, A. Farah, D. A. Silva, E. A. Nunan, and M. B. A. Glória, “Antibacterial Activity of Coffee Extracts and Selected Coffee Chemical Compounds against Enterobacteria,” Journal of Agricultural and Food Chemistry 54, no. 23 (2006): 8738–43.
   PubMed Web of Science ®Google Scholar
• H. Liu, D. Gu, G. Liu, X. Zhao, and C. Chen, “The Synthesis of Pentaerythrityl Tetraimdazole,” Procedia Engineering 18 (2011): 324–28.
   Google Scholar
• M. Arumugam, A. Mitra, P. Jaisankar, S. Dasgupta, T. Sen, R. Gachhui, U. K. Mukhopadhyay, and J. Mukherjee, “Isolation of an Unusual Metabolite 2-Allyloxyphenol from a Marine Actinobacterium, Its Biological Activities and Applications,” Applied Microbiology and Biotechnology 86, no. 1 (2010): 109–17.
   PubMed Web of Science ®Google Scholar
• F. Liu, V. E. C. Ooi, and S. T. Chang, “Free Radical Scavenging Activities of Mushroom Polysaccharide Extracts,” Life Sciences 60, no. 10 (1997): 763–71.
   PubMed Web of Science ®Google Scholar
• Y. Mizushima and M. Kobayashi, “Interaction of Anti-Inflammatory Drugs with Serum Proteins, Especially with Some Biologically Active Proteins,” The Journal of Pharmacy and Pharmacology 20, no. 3 (1968): 169–73.
   PubMed Web of Science ®Google Scholar
• S. Sakat, A. R. Juvekar, and M. N. Gambhire, “In Vitro Antioxidant and anti-Inflammatory Activity of Methanol Extract of Oxalis corniculata Linn,” Journal of Pharmacy and Pharmaceutical Sciences 2, no. 1 (2010): 146–55.
   Google Scholar
• L. B. Reller, M. Weinstein, J. H. Jorgensen, and M. J. Ferraro, “Antimicrobial Susceptibility Testing: A Review of General Principles and Contemporary Practices,” Clinical Infectious Diseases 49, no. 11 (2009): 1749–55.
   PubMed Web of Science ®Google Scholar