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Research Articles

Synthesis of New 6-Oxo-1,6-Dihydropyrimidin-5-Carboxamides and Evaluation of Their anti-Bacterial and anti-Oxidant Activities

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Pages 619-629 | Received 11 Aug 2021, Accepted 04 Dec 2021, Published online: 22 Dec 2021

References

  • F. Xie, H. Zhao, L. Zhao, L. Lou, and Y. Hu, “Synthesis and Biological Evaluation of Novel 2,4,5-Substituted Pyrimidine Derivatives for Anticancer Activity,” Bioorganic & Medicinal Chemistry Letters 19, no. 1 (2009): 275–8.
  • H. W. Lee, B. Y. Kim, J. B. Ahn, S. K. Kang, J. H. Lee, J. S. Shin, S. K. Ahn, S. J. Lee, and S. S. Yoon, “Molecular Design, Synthesis, and Hypoglycemic and Hypolipidemic Activities of Novel Pyrimidine Derivatives Having Thiazolidinedione,” European Journal of Medicinal Chemistry 40, no. 9 (2005): 862–74.
  • J. Balzarini, and C. McGuigan, “Bicyclic Pyrimidine Nucleoside Analogues (BCNAs) as Highly Selective and Potent Inhibitors of Varicella-Zoster Virus Replication,” The Journal of Antimicrobial Chemotherapy 50, no. 1 (2002): 5–9.
  • A. A. Abu-Hashem, M. M. Youssef, and H. A. R. Hussein, “Synthesis, Antioxidant, Antituomer Activities of Some New Thiazolopyrimidines, Pyrrolothiazolopyrimidines and Triazolopyrrolothiazolopyrimidines Derivatives,” Journal of the Chinese Chemical Society 58, no. 1 (2011): 41–8.
  • A. K. Gupta, Sanjay, H. P. Kayath, A. Singh, G. Sharma, and K. C. Mishra, “Anticonvulsant Activity of Pyrimidine Thiols,” Indian Journal of Pharmacology 26, no. 1994 (1994): 227–8.
  • N. Agarwal, P. Srivastava, S. K. Raghuwanshi, D. N. Upadhyay, S. Sinha, P. K. Shukla, and V. Ji Ram, “Chloropyrimidines as a New Class of Antimicrobial Agents,” Bioorganic & Medicinal Chemistry 10, no. 4 (2002): 869–74.
  • A. Krishna, V. Vijayakumar, and S. Sarveswari, “Synthesis of New 3‐(2‐Amino‐6‐Arylpyrimidin‐4‐yl)‐4‐Hydroxy Quinolin‐2(1H)‐Ones and Their in Vitro Antimicrobial and “DPPH,” ChemistrySelect 5, no. 26 (2020): 1972–7967.
  • M. Sankarganesh, J. Dhaveethu Raja, K. Sakthikumar, R. Vijay Solomon, J. Rajesh, S. Athimoolam, and V. Vijayakumar, “New Bio-Sensitive and Biologically Active Single Crystal of Pyrimidine Scaffold Ligand and Its Gold and Platinum Complexes: DFT, Antimicrobial, Antioxidant, DNA Interaction, Molecular Docking with DNA/BSA and Anticancer Studies,” Bioorganic Chemistry 81, (2018): 144–56.
  • G. L. Balaji, K. Rajesh, S. K. Ali, and V. Vijayakumar, “Ultrasound Prompted Synthesis of Novel 2-Chloroquinolin-4-Pyrimidine Carboxylate Derivatives as Potential Antibacterial Agents,” Research on Chemical Intermediates 39, no. 4 (2013): 1807–15.
  • P. Veerepalli, V. Vijayakumar, and S. Sarveswari, “Siderophore Inhibitors: synthesis and Antimycobacterial Evaluation of Certain Chromeno 4,3-d]Benzimidazo[1,2-a]Pyrimidines,” Journal of Pharmacy Research 5, (2012): 1027–33.
  • B. Kumar, B. Kaur, J. Kaur, A. Parmar, R. D. Anand, and H. Kumar, “Thermal/Microwave Assisted Synthesis of Substituted Tetrahydropyrimidines as Potent Calcium Channel Blockers,” Indian Journal of Chemistry Section B: Organic Chemistry Including Medicinal Chemistry. 41, (2002): 1526–30.
  • M. B. Elisabeth, H. Ralf, S. Astrid, E. Adrien, M. Eric, C. Vincent, H. Pierre, C. Jean, S. Roland, T. B. Mark, et al. “Acyl Derivatives of p-Aminosulfonamides and Dapsone as New Inhibitors of the Arginine Methyltransferase hPRMT1,” Bioorganic and Medicinal Chemistry 19, (2011) : 3717–31.
  • L. D. Wei, Y. X. Jing, X. X. Li, and M. L. Zheng, “Synthesis, Structure and Insecticidal Activities of Some Novel Amides Containing N-Pyridylpyrazole Moeities,”Molecules (Basel, Switzerland) 17, no. 9 (2012): 10414–28.
  • E. S. Berezina, V. O. Kozminykh, N. M. Igidov, S. S. Shirinkina, E. N. Kozminykh, R. R. Makhmudov, and E. V. Bukanova, “Acylpyruvic Acids Amides and Hydrazides: VIII. Synthesis of Pivaloylpyruvamides and Their Reactions with Benzylamine and Arylamines,” Russian Journal of Organic Chemistry 12, (2001) : 539–46.
  • D. Martin, Z. Jan, K. Diana, K. Jiri, and S. Michaela, “Substituted N-Phenylpyrazine-2-Carboxamides: Synthesis and Antimycobacterial Evaluation,” Molecule 14, (2009): 4180–9.
  • I. V. Ukrainets, N. L. Bereznyakova, V. A. Parshikov, and O. V. Gorokhova, “4-Hydroxy-2-Quinolones 150*. Efficient Synthesis, Structure, and Biological Activities of 4-Methyl-2-Oxo-1,2-Dihydroquinoline-3-Carboxylic Acid Alkyl Amides,” Chemistry of Heterocyclic Compounds 44, no. 12 (2008): 1493–9.
  • F. J. Weiberth, Y. Yu, W. Subotkowski, and C. Pemberton, “Demonstration on Pilot-Plant Scale of the Utility of 1, 5, 7-Triazabicyclo [4.4.0]Dec-5-Ene (TBD) as a Catalyst in the Efficient Amidation of an Unactivated Methyl Ester,” Organic Process Research & Development 16, no. 12 (2012): 1967–9.
  • K. A. Eliazyan, F. V. Avetisyan, T. L. Jivanshiryan, V. A. Pivazyan, E. A. Ghazaryan, L. V. Shahbazyan, S. V. Harutyunyan, and A. P. Yengoyan, “Synthesis and Fungicidal Activity of Novel 1, 3 ‐ Disubstituted 1H − Diazirine Derivatives,” Journal of Heterocyclic Chemistry 48, no. 1 (2011): 118–23.
  • B. Tabassum, K. Nithin, and D. Rupesh, “Free Radical Scavenging Properties of Pyrimidine Derivatives,” Organic and Medicinal Chemistry Letters 2, (2012): 1.
  • K. A. Hughes, T. P. Selby, and G. P. Lahm, “Novel Anthranilamide Insecticides,” US Patent US 2,006,001,4808 (2006).
  • Y. N. Xue, G. H. Liu, and S. Xue, “Synthesis and Herbicidal Activity of New 1-Alkyl-3-Aryloxypyrazole-4-Carboxamide Derivatives,” Chinese Journal of Chemistry 23, (2006): 1200–3.
  • B. Sreenivas, M. Akhila, and B. Mohammed, “Synthesis and Biological Evaluation of Pyrimidine Analogs as Potential Antimicrobial Agents,” International Journal of Pharmacy and Pharmaceutical Sciences 4, (2004): 306.
  • S. W. McCombie, J. R. Tagat, S. F. Vice, S.-I. Lin, R. Steensma, A. Palani, B. R. Neustadt, B. M. Baroudy, J. M. Strizki, M. Endres, et al. “Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. III: Synthesis, Antiviral and Pharmacokinetic Profiles of Symmetrical Heteroaryl Carboxamides,” Bioorganic & Medicinal Chemistry Letters 13, no. 3 (2003): 567–71.,
  • O. Alam, S. A. Khan, N. Siddiqui, W. Ahsan, S. P. Verma, and S. J. Gilani, “Antihypertensive Activity of Newer 1,4-Dihydro-5-pyrimidine Carboxamides: Synthesis and Pharmacological Evaluation ,” European Journal of Medicinal Chemistry 45, no. 11 (2010): 5113–9.
  • V. Virsodia, R. R. S. Pissurlenkar, D. Manvar, C. Dholakia, P. Adlakha, A. Shah, and E. C. Coutinho, “Synthesis, Screening for Antitubercular Activity and 3D-QSAR Studies of Substituted N-Phenyl-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxamides ,” European Journal of Medicinal Chemistry 43, no. 10 (2008): 2103–15.
  • H. Hisamichi, R. Naito, A. Toyoshima, N. Kawano, A. Ichikawa, A. Orita, M. Orita, N. Hamada, M. Takeuchi, M. Ohta, et al. “Synthetic Studies on Novel Syk Inhibitors. Part 1: Synthesis and Structure – Activity Relationships of Pyrimidine-5-Carboxamide Derivatives,” Bioorganic & Medicinal Chemistry 13, no. 16 (2005): 4936–51.,
  • E. Caroff, E. Meyer, A. Treiber, K. Hilpert, and A. R. Markus, “Optimization of 2-Phenyl-pyrimidine-4-carboxamides Towards Potent, Orally Bioavailable and Selective P2Y(12) Antagonists for Inhibition of Platelet Aggregation ,” Bioorganic & Medicinal Chemistry Letters 24, no. 17 (2014): 4323–31.
  • L. Wang, J. A. Hubert, S. J. Lee, J. Pan, S. Qian, M. L. Reitman, A. M. Strack, D. T. Weingarth, D. J. MacNeil, A. E. Weber, et al. “Discovery of Pyrimidine Carboxamides as Potent and Selective CCK1 Receptor Agonists,” Bioorganic & Medicinal Chemistry Letters 21, no. 10 (2011): 2911–5.,
  • CLSI, Performance Standards for Antimicrobial Disk Susceptibility Tests, Approved Standard, 7th ed., CLSI document M07-A9. Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA (2012).
  • J. H. Moon, and J. Terao, “Antioxidant Activity of Caffeic Acid and Dihydrocaffeic Acid in Lard and Human Low-Density Lipoprotein,” Journal of Agricultural and Food Chemistry 46, no. 12 (1998): 5062–5.

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