Cu(II)-Promoted the Chemical Synthesis of New Azines-Based Naphthalene Scaffold as In Vitro Potent Mushroom Tyrosinase Inhibitors and Evaluation of Their Antiproliferative Activity

References

• J. Safari, and S. Gandomi-Ravandi, “Structure, Synthesis and Application of Azines: A Historical Perspective,” RSC Advances 4, no. 86 (2014): 46224–49. https://doi.org/10.1039/c4ra04870a
   Web of Science ®Google Scholar
• S.S. Chourasiya, D. Kathuria, A.A. Wani, and P.V. Bharatam, “Azines: Synthesis, Structure, Electronic Structure and Their Applications,” Organic & Biomolecular Chemistry 17, no. 37 (2019): 8486–521. https://doi.org/10.1039/c9ob01272a
   PubMed Web of Science ®Google Scholar
• W. Han, G. Zhang, G. Li, and H. Huang, “Rh-Catalyzed Sequential Oxidative C − H and N − N Bond Activation: Conversion of Azines into Isoquinolines with Air at Room Temperature,” Organic Letters 16, no. 13 (2014): 3532–5. https://doi.org/10.1021/ol501483k
   PubMed Web of Science ®Google Scholar
• D.S. Deshmukh, P.A. Yadav, and B.M. Bhanage, “Cp*Co(III)-Catalyzed Annulation of Azines by C–H/N–N Bond Activation for the Synthesis of Isoquinolines,” Organic & Biomolecular Chemistry 17, no. 14 (2019): 3489–96. https://doi.org/10.1039/c9ob00174c
   PubMed Web of Science ®Google Scholar
• H.-M. Vu, J.-Y. Yong, F.-W. Chen, X.-Q. Li, and G.-Q. Shi, “Rhodium-Catalyzed C(sp2)-H Amidation of Azine with Sulfonamides,” The Journal of Organic Chemistry 85, no. 7 (2020): 4963–72. https://dx.doi.org/10.1021/acs.joc.0c00138
   PubMed Web of Science ®Google Scholar
• C. Obradors, and B. List, “Azine Activation via Silylium Catalysis,” Journal of the American Chemical Society 143, no. 18 (2021): 6817–22. −https://doi.org/10.1021/jacs.1c03257
   PubMed Web of Science ®Google Scholar
• Y.-G. Lim, and B.T. Koo, “Rhodium-Catalyzed Alkylation of Aromatic Azines with Alkenes via C–H Bond Activation,” Tetrahedron Letters 46, no. 3 (2005): 385–8. https://doi.org/10.1016/j.tetlet.2004.11.117
   Web of Science ®Google Scholar
• G.Yu Ishmuratov, G.R. Mingaleeva, M.P. Yakovleva, R.R. Muslukhov, O.O. Shakhanova, E.M. Vyrypaev, and A.G. Tolstikov, “Synthesis of Macrolides Containing an Azine or Hydrazide Fragment via Successive Tishchenko Disproportionation and [1 + 1]-Condensation,” Russian Journal of Organic Chemistry 47, no. 9 (2011): 1410–5. https://doi.org/10.1134/S1070428011090259
   Web of Science ®Google Scholar
• V.Ch Kravtsov, V. Lozovan, N. Siminel, E.B. Coropceanu, O.V. Kulikova, N.V. Costriucova, and M.S. Fonari, “From 1D to 2D Cd(II) and Zn(II) Coordination Networks by Replacing Monocarboxylate with Dicarboxylates in Partnership with Azine Ligands: Synthesis, Crystal Structures, Inclusion, and Emission Properties,” Molecules 25, no. 23 (2020): 5616. https://doi.org/10.3390/molecules25235616
   PubMed Web of Science ®Google Scholar
• S. Kagatikar, and D. Sunil, “Aggregation-Induced Emission of Azines: An Up-to-Date Review,” Journal of Molecular Liquids 292 (2019): 111371. https://doi.org/10.1016/j.molliq.2019.111371
   Web of Science ®Google Scholar
• Sultan Kulaksızoğlu, and Ramazan Gup, “A New Bis(Azine) Tetradentate Ligand and Its Transition Metal Complexes: Synthesis, Characterization, and Extraction Properties,” Chemical Papers 66, no. 3 (2012): 194–201. https://doi.org/10.2478/s11696-011-0126-y
   Web of Science ®Google Scholar
• Ahmed Orabi, Enass El-Sheikh, Mohammed Hassanin, Mohammed El Kady, Mohammed Abdel-Khalek, and Amera Mowafy, “Extraction of Rare Earth Elements from Abu–Tartour Wet Process Phosphoric Acid Using Synthesized Salicylaldehyde Azine,” Minerals Engineering 122 (2018): 113–21. https://doi.org/10.1016/j.mineng.2018.03.037
   Web of Science ®Google Scholar
• S. Kulaksizoğlua, C. Gökçea, and R. Gup, “Asymmetric Bis(Bidentate) Azine Ligand and Transition Metal Complexes: Synthesis, Characterization, DNA-Binding and Cleavage Studies and Extraction Properties for Selected Metals and Dichromate Anions,” Journal of the Chilean Chemical Society 57, no. 3 (2012): 1213–8. http://dx.doi.org/10.4067/S0717-97072012000300004
   Web of Science ®Google Scholar
• Saied M. Soliman, and Assem Barakat, “Self-Assembly of Azine-Based Hydrolysis of Pyridine and Isatin Oxamohydrazides with AgNO3; Synthesis and Structural Studies of a Novel Four Coordinated Ag(I)-Azine 2D Coordination Polymer,” Inorganica Chimica Acta 490 (2019): 227–34. https://doi.org/10.1016/j.ica.2019.03.023
   Web of Science ®Google Scholar
• D. Donnecke, K. Halbauer, and W. Imhof, “The Reaction of Ortho-Halogenated Aromatic Aldazine Ligands with Fe2(CO)9: Symmetrical Cleavage of the Azine and Carbon–Halogen Activation,” Journal of Organometallic Chemistry 689, no. 16 (2004): 2707–19. https://doi.org/10.1016/j.jorganchem.2004.04.049
   Web of Science ®Google Scholar
• A. Singh, M. Chandra, A.N. Sahay, D.S. Pandey, K.K. Pandey, S.M. Mobin, M.C. Puerta, and P. Valerga, “Arene Ruthenium Complexes Incorporating Immine/Azine Hybrid-Chelating N–N0 Donor Ligands: Synthetic, Spectral, Structural Aspects and DFT Studies,” Journal of Organometallic Chemistry 689, no. 10 (2004): 1821–34. https://doi.org/10.1016/j.jorganchem.2004.02.037
   Web of Science ®Google Scholar
• M. Revanasiddappa, T. Suresh, S. Khasim, S.C. Raghavendra, C. Basavaraja, and S.D. Angadi, “Transition Metal Complexes of 1, 4(2'-Hydroxyphenyl-1-yl) di-Imino Azine: Synthesis, Characterization and Antimicrobial Studies,” Journal of Chemistry 5 (2008): 328961. https://doi.org/10.1155/2008/328961
   Web of Science ®Google Scholar
• N.M. Irmi, B. Purwono, and C. Anwar, “Synthesis of Symmetrical Acetophenone Azine Derivatives as Colorimetric and Fluorescent Cyanide Chemosensors,” Indonesian Journal of Chemistry 21, no. 6 (2021): 1337–47. https://doi.org/10.22146/ijc.64428
   Web of Science ®Google Scholar
• A. Caballero, R. Martınez, V. Lloveras, I. Ratera, J. Vidal-Gancedo, K. Wurst, A. Tarraga, P. Molina, and J. Veciana, “Highly Selective Chromogenic and Redox or Fluorescent Sensors of Hg2+ in Aqueous Environment Based on 1,4-Disubstituted Azines,” Journal of the American Chemical Society 127, no. 45 (2005): 15666–7. https://doi.org/10.1021/ja0545766
   PubMed Web of Science ®Google Scholar
• R. Martınez, A. Espinosa, A. Tarraga, and P. Molina, “New Hg2+ and Cu2+ Selective Chromoand Fluoroionophore Based on a Bichromophoric Azine,” Organic Letters 7, no. 26 (2005): 5869–72. https://doi.org/10.1021/ol052508i
   PubMed Web of Science ®Google Scholar
• S. Manigandan, A. Muthusamy, R. Nandhakumar, and C.I. David, “Recognition of Fe3+ by a New Azine-Based Fluorescent “Turn-off” Chemosensor and Its Binding Mode Analysis Using DFT,” Journal of Molecular Structure 1208 (2020): 127834. https://doi.org/10.1016/j.molstruc.2020.127834
   Web of Science ®Google Scholar
• L. Peng, Z. Zhou, R. Wei, K. Li, P. Song, and A. Tong, “A Fluorescent Probe for Thiols Based on Aggregation-Induced Emission and Its Application in Live-Cell Imaging,” Dyes and Pigments 108 (2014): 24–31. http://dx.doi.org/10.1016/j.dyepig.2014.04.020
   Web of Science ®Google Scholar
• R. Kaushik, A. Ghosh, A. Singh, and D.A. Jose, “Colorimetric Sensor for the Detection of H2S and Its Application in Molecular Half-Subtractor,” Analytica Chimica Acta 1040 (2018): 177–86. https://doi.org/10.1016/j.aca.2018.08.028
   PubMed Web of Science ®Google Scholar
• N. Hidayah, B. Purwono, and H.D. Pranowo, “Symmetrical Azine Colorimetric and Fluorometric Turn-Off Chemosensor for Formaldehyde Detection,” Sains Malaysiana 48, no. 10 (2019): 2161–7. http://dx.doi.org/10.17576/jsm-2019-4810-11
   Web of Science ®Google Scholar
• Y.D. Farahani, and V. Safarifard, “Highly Selective Detection of Fe3+, Cd2+ and CH2Cl2 Based on a Fluorescent Zn-MOF with Azine-Decorated Pores,” Journal of Solid State Chemistry 275 (2019): 131–40. https://doi.org/10.1016/j.jssc.2019.04.018
   Web of Science ®Google Scholar
• Q. Wei, L. Shi, H. Cao, L. Wang, H. Yang, and Y. Wang, “Synthesis and Mesomorphic Properties of Two Series of New Azine‐Type Liquid Crystals,” Liquid Crystals 35, no. 5 (2008): 581–5. http://dx.doi.org/10.1080/02678290802028773
   Web of Science ®Google Scholar
• S. Upadyaya, P. Bhagavath, and D. Sunil, “Azines as Liquid Crystalline Materials: An up-to-Date Review,” Journal of Molecular Liquids 269 (2018): 354–70. https://doi.org/10.1016/j.molliq.2018.08.035
   Web of Science ®Google Scholar
• M. Lewis, C.L. Barnes, and R. Glaser, “4-Chloroacetophenone [1-(4-Methoxyphenyl)Ethylidene]Hydrazone,” Acta Crystallographica Section C Crystal Structure Communications 56, no. 3 (2000): 393–6. http://doi.org/10.1107/S0108270199011737
   PubMedGoogle Scholar
• R.P. Ortiz, H. Yan, A. Facchetti, and T.J. Marks, “Azine- and Azole-Functionalized Oligó and Polythiophene Semiconductors for Organic Thin-Film Transistors,” Materials 3, no. 3 (2010): 1533–58. https://doi.org/10.3390/ma3031533
   Web of Science ®Google Scholar
• H. Mailer, and S. Laskos, “Azine Liquid Crystal Compounds for Use in Light-Control Devices,” United States Patent 4265784.
   Google Scholar
• J. Ardaraviciene, B. Barvainiene, T. Malinauskas, V. Jankauskas, K. Arlauskas, and V. Getautis, “Symmetrical Azine-Based Polymers Possessing 1-Phenyl-1,2,3,4-Tetrahydroquinoline Moieties as Materials for Optoelectronics,” Reactive and Functional Polymers 71, no. 10 (2011): 1016–22. https://doi.org/10.1016/j.reactfunctpolym.2011.07.005
   Web of Science ®Google Scholar
• Christine McLoughlin, Jason A.C. Clyburne, and Noham Weinberg, “Azines: Conjugation Stoppers or Conjugation Switches,” Journal of Materials Chemistry 17, no. 40 (2007): 4304–8. https://doi.org/10.1039/b706964b
   Web of Science ®Google Scholar
• Pengxin Guan, Jikuan Qiu, Yuling Zhao, Huiyong Wang, Zhiyong Li, Yunlei Shi, and Jianji Wang, “A Novel Crystalline Azine-Linked Three-Dimensional Covalent Organic Framework for CO2 Capture and Conversion,” Chemical Communications 55, no. 83 (2019): 12459–62. https://doi.org/10.1039/c9cc05710b
   PubMed Web of Science ®Google Scholar
• V.S. Vyas, F. Haase, L. Stegbauer, G. Savasci, F. Podjaski, C. Ochsenfeld, and B.V. Lotsch, “A Tunable Azine Covalent Organic Framework Platform for Visible Light-Induced Hydrogen Generation,” Nature Communications 6 (2015): 8508. https://doi.org/10.1038/ncomms9508
   PubMed Web of Science ®Google Scholar
• S. Dalapati, S. Jin, J. Gao, Y. Xu, A. Nagai, and D. Jiang, “An Azine-Linked Covalent Organic Framework,” Journal of the American Chemical Society 135, no. 46 (2013): 17310–3. −3. https://doi.org/10.1021/ja4103293
   PubMed Web of Science ®Google Scholar
• F. Haase, T. Banerjee, G. Savasci, C. Ochsenfeld, and B.V. Lotsch, “Structure–Property–Activity Relationships in a Pyridine Containing Azine-Linked Covalent Organic Framework for Photocatalytic Hydrogen Evolution,” Faraday Discussions 201 (2017): 247–64. https://doi.org/10.1039/c7fd00051k
   PubMed Web of Science ®Google Scholar
• S. Zhao, F. Chen, X. Zhu, W. Liu, C. Wu, J. Zhang, S. Ren, Z. Yan, W. Cao, Q. Zhang, et al., “An Azine-Based Polymer Derived Hierarchically Porous N–Doped Carbon for Hydrophilic Dyes Removal,” Journal of Hazardous Materials 413 (2021): 125299. https://doi.org/10.1016/j.jhazmat.2021.125299
   PubMed Web of Science ®Google Scholar
• T. Kotnik, G. Žerjav, A. Pintar, E. Žagar, and S. Kovačič, “Azine- and Imine-Linked Conjugated polyHIPEs through Schiff-Base Condensation Reaction,” Polymer Chemistry 13, no. 4 (2022): 474–8. https://doi.org/10.1039/d1py01467f
   Web of Science ®Google Scholar
• Kamal I. Aly, Mohamed Gamal Mohamed, Osama Younis, Mahmoud H. Mahross, Mohamed Abdel-Hakim, and Marwa M. Sayed, “Salicylaldehyde Azine-Functionalized Polybenzoxazine: Synthesis, Characterization, and Its Nanocomposites as Coatings for Inhibiting the Mild Steel Corrosion,” Progress in Organic Coatings 138 (2020): 105385.
   Web of Science ®Google Scholar
• A.R. Kennedy, K.G. Brown, D. Graham, J.B. Kirkhouse, M. Kittner, C. Major, C.J. McHugh, P. Murdoch, and W.E. Smith, “Chromophore Containing Bipyridyl Ligands. Part 1: Supramolecular Solid-State Structure of Ag(I) complexes,” New Journal of Chemistry 29, no. 6 (2005): 826–32. https://doi.org/10.1039/B500698H
   Web of Science ®Google Scholar
• S. Karimian, F. Kazemi, M. Attarroshan, M. Gholampour, S. Hemmati, A. Sakhteman, Y. Behzadipour, M. Kabiri, A. Iraji, and M. Khoshneviszadeh, “Design, Synthesis, and Biological Evaluation of Symmetrical Azine Derivatives as Novel Tyrosinase Inhibitors,” BMC Chemistry 15, no. 1 (2021): 54. https://doi.org/10.1186/s13065-021-00780-z
   PubMed Web of Science ®Google Scholar
• M. Ganga, and K.R. Sankaran, “Synthesis, Spectral Characterization, DFT, Molecular Docking and Biological Evaluation of Some Newly Synthesized Asymmetrical Azines of 3,5-Dimethoxy-4–Hydroxybenzaldehyde,” Chemical Data Collections 28 (2020): 100475. https://doi.org/10.1016/j.cdc.2020.100475
   Google Scholar
• E. Abdel-Galil, M.M. Girges, and G.E. Said, “Synthesis and Biological Studies of Some New Thiazoles, Hydrazones and Azine Derivatives Based on 3,5-Diphenylcyclohex-2-en-1-One,” ChemistrySelect 5, no. 10 (2020): 3075–9. https://doi.org/10.1002/slct.201904770
   Web of Science ®Google Scholar
• Nurul Hidayah, Bambang Purwono, and Harno Dwi Pranowo, “One Step Synthesis of Symmetrical Amino Azine Derivatives Using Hydrazine Hydrate as a Reagent,” Key Engineering Materials 840 (2020): 257–64. https://doi.org/10.4028/www.scientific.net/KEM.840.257
   Google Scholar
• R. Ujjinamatada, and Y.S. Agasimundin, “Reaction of 2-Acetylbenzofuranhydrazone with Aromatic Aldehydes: Formation of Aldzaines and Regeneration of 2-Acetylbenzofuran,” Indian Journal of Chemistry Section B 46 (2007): 540–3. http://nopr.niscair.res.in/handle/123456789/477.
   Web of Science ®Google Scholar
• V. Arun, and K.R. Sankaran, “Efficient and Eco–Friendly Synthesis of Fluorenone Azines by Using Sulphated Titania Acid Catalyst,” International Letters of Chemistry,” International Letters of Chemistry, Physics and Astronomy 58 (2015): 137–43. https://doi.org/10.18052/www.scipress.com/ILCPA.58.137
   Google Scholar
• J. Safari, S. Gandomi-Ravandi, and M. Monemi, “Novel and Selective Synthesis of Unsymmetrical Azine Derivatives via a Mild Reaction,” Monatshefte Für Chemie - Chemical Monthly 144, no. 9 (2013): 1375–80. https://doi.org/10.1007/s00706-013-0945-3
   Google Scholar
• J. Safari, and S. Gandomi-Ravandi, “Highly Efficient Practical Procedure for the Synthesis of Azine Derivatives under Solvent-Free Conditions,” Synthetic Communications 41, no. 5 (2011): 645–51. http://doi.org/10.1080/00397911003629523
   Web of Science ®Google Scholar
• K. Ravi, B. Krishnakumar, and M. Swaminathan, “An Efficient Protocol for the Green and Solvent-Free Synthesis of Azine Derivatives at Room Temperature Using BiCl3-Loaded Montmorillonite K10 as a New Recyclable Heterogeneous Catalyst,” ISRN Organic Chemistry 2012 (2012): 595868. https://doi.org/10.5402/2012/595868
   PubMedGoogle Scholar
• M.A. Valle-Amores, M. Blanco, S. Agnoli, A. Fraile, and J. Alemán, “Oxidized Multiwalled Nanotubes as Efficient Carbocatalyst for the General Synthesis of Azines,” Journal of Catalysis 406 (2022): 174–83. https://doi.org/10.1016/j.jcat.2022.01.009
   Web of Science ®Google Scholar
• R.E. Khidre, H.A. Mohamed, B.M. Kariuki, and G.A. El-Hiti, “Facile, Mild and Efficient Synthesis of Azines Using Phosphonic Dihydrazide,” Phosphorus, Sulfur, and Silicon and the Related Elements 195, no. 1 (2020): 29–36. https://doi.org/10.1080/10426507.2019.1633531
   Web of Science ®Google Scholar
• J. Lasri, and A.I. Ismail, “Metal-Free and FeCl3-Catalyzed Synthesis of Azines and 3,5-Diphenyl-1H-Pyrazole from Hydrazones and/or Ketones Monitored by High Resolution ESI+-MS,” Indian Journal of Chemistry Section B 57 (2018): 362–73. http://nopr.niscair.res.in/handle/123456789/43824.
   Web of Science ®Google Scholar
• S. Saranya, R. Ramesh, and D. Semeril, “Non-Pincer-Type Arene Ru(II) Catalysts for the Direct Synthesis of Azines from Alcohols and Hydrazine under Aerobic Conditions,” Organometallics 39, no. 17 (2020): 3194–201. https://doi.org/10.1021/acs.organomet.0c00367
   Web of Science ®Google Scholar
• J.O. Bauer, G. Leitus, Y. Ben-David, and D. Milstein, “Direct Synthesis of Symmetrical Azines from Alcohols and Hydrazine Catalyzed by a Ruthenium Pincer Complex: Effect of Hydrogen Bonding,” ACS Catalysis 6, no. 12 (2016): 8415–9. https://doi.org/10.1021/acscatal.6b02946
   PubMed Web of Science ®Google Scholar
• M. Chakraborty, D. Sengupta, T. Saha, and S. Goswami, “Ligand Redox-Controlled Tandem Synthesis of Azines from Aromatic Alcohols and Hydrazine in Air: One-Pot Synthesis of Phthalazine,” The Journal of Organic Chemistry 83, no. 15 (2018): 7771–8. https://doi.org/10.1021/acs.joc.8b00661
   PubMed Web of Science ®Google Scholar
• B.A. Shiekh, D. Kaur, and S.K. Godara, “Unprecedented Synthesis of Symmetrical Azines from Alcohols and Hydrazine Hydrate Using Nickel Based NNN-Pincer Catalyst: An Experimental and Computational Study,” Catalysis Communications 124 (2019): 19–23. https://doi.org/10.1016/j.catcom.2019.02.024
   Web of Science ®Google Scholar
• W.M. Dagnaw, Y. Lu, R. Zhao, and Z.-X. Wang, “DFT Study of PNP-Mn-Catalyzed Acceptorless Dehydrogenative Coupling of Primary Alcohols with Hydrazine to Give Alkene or Azine,” Organometallics 38, no. 19 (2019): 3590–601. https://doi.org/10.1021/acs.organomet.9b00429
   Web of Science ®Google Scholar
• J. Kishore, S. Thiyagarajan, and C. Gunanathan, “Ruthenium(II)-Catalysed Direct Synthesis of Ketazines Using Secondary Alcohols,” Chemical Communications 55, no. 31 (2019): 4542–5. https://doi.org/10.1039/C9CC01383K
   PubMed Web of Science ®Google Scholar
• C. Liang, J. Xia, D. Lei, X. Li, Q. Yao, and J. Gao, “Synthesis, In Vitro and In Vivo Antitumor Activity of Symmetrical bis-Schiff Base Derivatives of Isatin,” European Journal of Medicinal Chemistry 74 (2014): 742–50. http://dx.doi.org/10.1016/j.ejmech.2013.04.040
   PubMed Web of Science ®Google Scholar
• N. Phiromphu, S. Suramitr, R. Chotima, B. Boonseng, A. Songsasen, and A. Piyasaengthong, “Azine-Hydrazone Tautomerism of Thiazolylazo Pyridine Compound: Synthesis, Structural Determination, and Biological Activities,” Journal of Molecular Structure 1230 (2021): 129658. https://doi.org/10.1016/j.molstruc.2020.129658
   Web of Science ®Google Scholar
• T.-S. Chang, “An Updated Review of Tyrosinase Inhibitors,” International Journal of Molecular Sciences 10, no. 6 (2009): 2440–75. https://doi.org/10.3390/ijms10062440
   PubMed Web of Science ®Google Scholar
• S. Zolghadri, A. Bahrami, M. Tareq, H. Khan, J. Munoz-Munoz, F. Garcia-Molina, F. Garcia-Canovas, and A.A. Saboury, “A Comprehensive Review on Tyrosinase Inhibitors,” Journal of Enzyme Inhibition and Medicinal Chemistry 34, no. 1 (2019): 279–309. https://doi.org/10.1080/14756366.2018.1545767
   PubMed Web of Science ®Google Scholar
• S. Makar, T. Saha, and S.K. Singh, “Naphthalene, a Versatile Platform in Medicinal Chemistry: Sky-High Perspective,” European Journal of Medicinal Chemistry 161 (2019): 252–76. https://doi.org/10.1016/j.ejmech.2018.10.018
   PubMed Web of Science ®Google Scholar
• G. Wang, W. Liu, M. Fan, M. He, Y. Li, and Z. Peng, “Design, Synthesis and Biological Evaluation of Novel Thiazole-Naphthalene Derivatives as Potential Anticancer Agents and Tubulin Polymerisation Inhibitors,” Journal of Enzyme Inhibition and Medicinal Chemistry 36, no. 1 (2021): 1694–702. https://doi.org/10.1080/14756366.2021.1958213
   PubMed Web of Science ®Google Scholar
• G. Wang, W. Liu, J. Tang, X. Ma, Z. Gong, Y. Huang, Y. Li, and Z. Peng, “Design, Synthesis, and Anticancer Evaluation of Benzophenone Derivatives Bearing Naphthalene Moiety as Novel Tubulin Polymerization Inhibitors,” Bioorganic Chemistry 104 (2020): 104265. https://doi.org/10.1016/j.bioorg.2020.104265
   PubMed Web of Science ®Google Scholar
• A. Bhattacharyya, S.C. Makhal, S. Ghosh, and N. Guchhait, “Employing a Hydrazine Linked Asymmetric Double Naphthalene Hybrid for Efficient Naked Eye Detection of F-: Crystal Structure with Real Application for F,” Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 198 (2018): 107–14. https://doi.org/10.1016/j.saa.2018.03.001
   PubMed Web of Science ®Google Scholar
• E. Juwiyatri, S.N. Fauza, and N. Afriana, “Synthesis, In Vitro Antioxidant Activity, and Toxicity Evaluation of Hydrazone Derivatives Naphthalene-1-Ylmethylene Hydrazine,” Journal of Physics: Conference Series 2049, no. 1 (2021): 012050. https://doi.org/10.1088/1742-6596/2049/1/012050
   Google Scholar
• S. Brogi, T.C. Ramalho, K. Kuca, J.L. Medina-Franco, and M. Valko, “Editorial: In Silico Methods for Drug Design and Discovery,” Frontiers in Chemistry 8 (2020): 612. https://doi.org/10.3389/fchem.2020.00612
   PubMed Web of Science ®Google Scholar
• G. Xiong, Z. Wu, J. Yi, L. Fu, Z. Yang, C. Hsieh, M. Yin, X. Zeng, C. Wu, A. Lu, et al., “ADMETlab 2.0: An Integrated Online Platform for Accurate and Comprehensive Predictions of ADMET Properties,” Nucleic Acids Research 49, NO. W1 (2021): W5–W14. https://doi.org/10.1093/nar/gkab255
   PubMed Web of Science ®Google Scholar
• R.R. Miller, M. Madeira, H.B. Wood, W.M. Geissler, C.E. Raab, and I.J. Martin, “Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization,” Journal of Medicinal Chemistry 63, no. 21 (2020): 12156–70. https://doi.org/10.1021/acs.jmedchem.9b01813
   PubMed Web of Science ®Google Scholar
• R. Rafique, S.M. Saad, A.K.M. Khan, S. Perveen, and M. Taha, “Facile CuCl2.2H2O Catalyzed One-Pot Conversion of Dimedone into Highly Functionalized Indazole Based N-Arylhydrazinecarbothioamides,” Journal of Saudi Chemical Society 24, no. 1 (2020): 92–7. https://doi.org/10.1016/j.jscs.2019.09.006
   Web of Science ®Google Scholar
• A.H. Halawa, A.A. Eskandrani, W.E. Elgammal, S.M. Hassan, A.H. Hassan, H.Y. Ebrahim, A.B.M. Mehany, A.M. El-Agrody, and R.M. Okasha, “Rational Design and Synthesis of Diverse Pyrimidine Molecules Bearing Sulfonamide Moiety as Novel ERK Inhibitors,” International Journal of Molecular Sciences 20, no. 22 (2019): 5592. https://doi.org/10.3390/ijms20225592
   PubMed Web of Science ®Google Scholar
• A.H. Halawa, W.E. Elgammal, S.M. Hassan, A.H. Hassan, H.S. Nassar, H.Y. Ebrahim, A.B.M. Mehany, and A.M. El-Agrody, “Synthesis, Anticancer Evaluation and Molecular Docking Studies of New Heterocycles Linked to Sulfonamide Moiety as Novel Human Topoisomerase Types I and II Poisons,” Bioorganic Chemistry 98 (2020): 103725. https://doi.org/10.1016/j.bioorg.2020.103725
   PubMed Web of Science ®Google Scholar
• K.-C. Hsu, Y.-F. Chen, S.-R. Lin, and J.-M. Yang, “iGEMDOCK: A Graphical Environment of Enhancing GEMDOCK Using Pharmacological Interactions and Post-Screening Analysis,” BMC Bioinformatics 12, NO. S1 (2011): S33. https://doi.org/10.1186/1471-2105-12-S1-S33
   PubMedGoogle Scholar
• E.M. Eliwa, M. Frese, A.H. Halawa, M.M. Soltan, L.V. Ponomareva, J.S. Thorson, K.A. Shaaban, M. Shaaban, A.M. El-Agrody, and N. Sewald, “Metal-Free Domino amination-Knoevenagel Condensation Approach to Access New Coumarins as Potent Nanomolar Inhibitors of VEGFR-2 and EGFR,” Green Chemistry Letters and Reviews 14, no. 4 (2021): 578–97. https://doi.org/10.1080/17518253.2021.1981462
   PubMed Web of Science ®Google Scholar
• C. Zou, W. Huang, G. Zhao, X. Wan, X. Hu, Y. Jin, J. Li, and J. Liu, “Determination of the Bridging Ligand in the Active Site of Tyrosinase,” Molecules 22, no. 11 (2017): 1836. https://doi.org/10.3390/molecules22111836
   PubMed Web of Science ®Google Scholar
• V. Vichai, and K. Kirtikara, “Sulforhodamine B Colorimetric Assay for Cytotoxicity Screening,” Nature Protocols 1, no. 3 (2006): 1112–6. https://doi.org/10.1038/nprot.2006.179
   PubMed Web of Science ®Google Scholar
• A. Jasz, A. Rak, I. Ladjanszki, and G. Cserey, “Optimized GPU Implementation of Merck Molecular Force Field and Universal Force Field,” Journal of Molecular Structure 1188 (2019): 227–33. https://doi.org/10.1016/j.molstruc.2019.04.007
   Web of Science ®Google Scholar