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Research Articles

Silibinin ameliorates the cardiovascular oxidative and inflammatory effects of type-2-diabetic rats exposed to air particulate matter

ORCID Icon, , , & ORCID Icon
Pages 6570-6596 | Received 04 Jan 2022, Accepted 03 Sep 2022, Published online: 27 Sep 2022

References

  • M. K. Brahma, M. E. Pepin, and A. R. Wende, “My Sweetheart is Broken: role of Glucose in Diabetic Cardiomyopathy,” Diabetes & Metabolism Journal 41, no. 1 (2017): 1–9.
  • X. Luo, J. Wu, S. Jing, and L. J. Yan, “Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity,” Aging and Disease 7, no. 1 (2016): 90–110.
  • H. Zheng, J. Wu, Z. Jin, and L. J. Yan, “Protein Modifications as Manifestations of Hyperglycemic Glucotoxicity in Diabetes and Its Complications,” Biochemistry Insights 9 (2016): 1–9.
  • J. Wu, Z. Jin, and L. J. Yan, “Redox Imbalance and Mitochondrial Abnormalities in the Diabetic Lung,” Redox Biology 11 (2017): 51–9.
  • J. Wu, Z. Jin, H. Zheng, and L. J. Yan, “Sources and Implications of NADH/NAD + Redox Imbalance in Diabetes and Its Complications,” Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 9 (2016): 145–153.
  • World Health Organization. Global Status Report on Non-Communicable Diseases (Geneva: World Health Organization, 2014).
  • P. V. Dludla, E. Joubert, C. Muller, J. Louw, and R. Johnson, “Hyperglycemia-Induced Oxidative Stress and Heart Disease-Cardioprotective Effects of Rooibos Flavonoids and Phenylpyruvic Acid-2-O-β-D-Glucoside,” Nutrition & Metabolism 14 (2017): 45.
  • J. Yan, J. Jiang, L. He, and L. Chen, “Mitochondrial Superoxide/Hydrogen Peroxide: An Emerging Therapeutic Target for Metabolic Diseases,” Free Radical Biology & Medicine 152 (2020): 33–42.
  • G. Casaclang-Verzosa, “Diastolic Function Assessment in Atrial Fibrillation Conundrum,” International Journal of Heart Failure 2, no. 2 (2020): 115–117.
  • GBD 2015 Risk Factors Collaborators. “Global, Regional, and National Comparative Risk Assessment of 79 Behavioral, Environmental and Occupational, and Metabolic Risks or Clusters of Risks, 1990–2015: A Systematic Analysis for the Global Burden of Disease Study 2015,” Lancet 388 (2016): 1659–1624.
  • Philip J. Landrigan, Richard Fuller, Nereus J. R. Acosta, Olusoji Adeyi, Robert Arnold, Niladri Nil Basu, Abdoulaye Bibi Baldé, Roberto Bertollini, Stephan Bose-O'Reilly, Jo Ivey Boufford, et al., “The Lancet Commission on Pollution and Health,” Lancet (London, England) 391, no. 10119 (2018): 462–512.
  • R. D. Brook, S. Rajagopalan, C. A. Pope, III, J. R. Brook, A. Bhatnagar, A. V. Diez-Roux, F. Holguin, Y. Hong, R. V. Luepker, M. A. Mittleman, et al., “Particulate Matter Air Pollution and Cardiovascular Disease: An Update to the Scientific Statement from the American Heart Association,” Circulation 121, no. 21 (2010): 2331–2378.
  • David E. Newby, Pier M. Mannucci, Grethe S. Tell, Andrea A. Baccarelli, Robert D. Brook, Ken Donaldson, Francesco Forastiere, Massimo Franchini, Oscar H. Franco, Ian Graham, ESC Heart Failure Association, et al., “Expert Position Paper on Air Pollution and Cardiovascular Disease,” European Heart Journal 36, no. 2 (2015): 83–93b.
  • V. Sharma, B. Aneja, V. K. Yata, D. Malakar, and A. K. Mohanty, “Systemic Nanotoxicity and Its Assessment in Animal Models,” Nanopharmaceuticals: Principles and Applications 3(2020): 201–243.
  • A. P. Adjani, S. Joel, R. G. Diane, M. V. Judith, V. Roel, and G. Ulrike, “Quantile Regression to Examine the Association of Air Pollution with Subclinical Atherosclerosis in an Adolescent Population,” Environment International 164 (2022): 107285.
  • J. G. Nathanael, B. Yuan, and U. Wille, “Oxidative Damage of Aliphatic Amino Acid Residues by the Environmental Pollutant NO3·: Impact of Water on the Reactivity,” Environmental Science & Technology 56, no. 12 (2022): 7687–95.
  • B. Sivakumar, and G. A. Kurian, “Diesel Particulate Matter Exposure Deteriorates Cardiovascular Health and Increases the Sensitivity of Rat Heart towards Ischemia Reperfusion Injury via Suppressing Mitochondrial Bioenergetics Function,” Chemico-Biological Interactions 351 (2022): 109769.
  • Z. Song, Y. Guo, M. Zhou, and X. Zhang, “The PI3K/pAkt Signaling Pathway Participates in Calcitriol Ameliorating Podocyte Injury in DN Rats,” Metabolism 63, no. 10 (2014): 1324–1333.
  • Ophélie Germande, Thomas Ducret, Jean-Francois Quignard, Juliette Deweirdt, Véronique Freund-Michel, Marie-Hélène Errera, Guillaume Cardouat, Pierre Vacher, Bernard Muller, Patrick Berger, et al., “NiONP-Induced Oxidative Stress and Mitochondrial Impairment in an in Vitro Pulmonary Vascular Cell Model Mimicking Endothelial Dysfunction,” Antioxidants 11, no. 5 (2022): 847.
  • P. Pirot, A. K. Cardozo, and D. L. Eizirik, “Mediators and Mechanisms of Pancreatic Beta-Cell Death in Type 1 Diabetes,” Arquivos Brasileiros de Endocrinologia e Metabologia 52, no. 2 (2008): 156–165.
  • C. S. Weldy, H. Wilkerson, T. V. Larson, J. A. Stewart, and T. J. Kavanagh, “Diesel Particulate Exposed Macrophages Alter Endothelial Cell Expression of eNOS, iNOS, MCP1, and Glutathione Synthesis Genes,” Toxicology in Vitro : An International Journal Published in Association with BIBRA 25, no. 8 (2011): 2064–2073.
  • N. Alizadeh, M. Eskandani, K. Tondro, M. Rashidi, and H. Nazemiyeh, “Inhibitory Effects of Flavonolignans from Silybum Marianum (L.) Gaertn (Milk Thistle) on Function of Aldehyde Oxidase and Xanthine Oxidase in Rats,” Letters in Drug Design & Discovery 15, no. 3 (2018): 256–262.
  • E. Köksal, I. Gülcin, S. Beyza, O. Sarikaya, and E. Bursal, “In Vitro Antioxidant Activity of Silymarin,” Journal of Enzyme Inhibition and Medicinal Chemistry 24, no. 2 (2009): 395–405.
  • Federico Salamone, Fabio Galvano, Antonella Marino Gammazza, Antonella Marino, Claudia Paternostro, Daniele Tibullo, Fabio Bucchieri, Andrea Mangiameli, Maurizio Parola, Elisabetta Bugianesi, et al., “Silibinin Improves Hepatic and Myocardial Injury in Mice with Nonalcoholic Steatohepatitis,” Digestive and Liver Disease : official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 44, no. 4 (2012): 334–342.
  • L. Radkoand, and W. Cybulski, “Application of Silymarin in Human and Animal Medicine,” Journal of Pre-Clinical and Clinical Research 1 (2007): 22–26.
  • A. O. Lawal, and O. O. Elekofehinti, “Real Time-Quantitative Polymerase Chain Reaction Analysis of the anti-Inflammatory Effect of Aqueous Rooibos (Aspalathus Linearis) Extract on Diesel Exhaust Particles-Induced Hepatic Inflammation,” Ife Journal of Science 21, no. 1 (2019): 175–186.
  • A. O. Lawal, M. Zhang, M. Dittmar, A. Lulla, and J. A. Araujo, “Heme oxygenase1 Protects Endothelial Cells from the Toxicity of Air Pollutant Chemicals,” Toxicology and Applied Pharmacology 284, no. 3 (2015): 281–291.
  • R. D. Wilson, and M. S. Islam, “Fructose-Fed Streptozotocin-Injected Rat: An Alternative Model for Type 2 Diabetes,” Pharmacological Reports 64, no. 1 (2012): 129–139.
  • D. Jain, R. Somani, and R. Gilhotra, “Silibinin Ameliorates Hyperglycemia, Hyperlipidemia and Prevents Oxidative Stress in Streptozotocin-Induced Diabetes in Sprague Dawley Rats,” Int. J. Pharmaceutical Research and Allied Sciences 5, no. 3 (2016): 136–144.
  • S. Yokota, H. Takashima, R. Ohta, Y. Saito, T. Miyahara, Y. Yoshida, T. Negura, M. Senuma, K. Usumi, N. Hirabayashi, et al., “Nasal Instillation of Nanoparticle-Rich Diesel Exhaust Particles Slightly Affects Emotional Behavior and Learning Capability in Rats,” The Journal of Toxicological Sciences 36, no. 3 (2011): 267–276.
  • Marjorie Giacometi, Lucas Trevisan Gressler, Letícia dos Santos Petry, Antônio FranciscoIgor Magalhães de Matos, Janaína Brand Dillmann, Talissa Silva dos Santos, Eduarda Maria Santi, Alexia Brauner de Mello, Aline Ourique, Silvia Gonzalez Monteiro, et al., “Antioxidant and Nematocidal Effects of Several Oyster Mushroom Species of Genus Pleurotus (Agaricomycetes),” International Journal of Medicinal Mushrooms 24, no. 6 (2022): 35–45.
  • R. R. Emmons, C. M. Cirnigliaro, S. C. Kirshblum, and W. A. Bauman, “The Relationship between the Postprandial Lipemic Response and Lipid Composition in Persons with Spinal Cord Injury,” The Journal of Spinal Cord Medicine 37, no. 6 (2014): 765–773.
  • Ziteng Lian, Sai Yang, Shicheng Dai, Xiaohong Tong, Peilong Liao, Lin Cheng, Weijie Qi, Yijun Wang, Huan Wang, Lianzhou Jiang, et al., “Relationship between Flexibility and Interfacial Functional Properties of Soy Protein Isolate: Succinylation Modification,” Journal of the Science of Food and Agriculture (2022). doi: 10.1002/jsfa.12012
  • Kathrin Wolf, Anita Popp, Alexandra Schneider, Susanne Breitner, Regina Hampel, Wolfgang Rathmann, Christian Herder, Michael Roden, Wolfgang Koenig, Christa Meisinger, for the KORA-Study Group, et al., “Association between Long-Term Exposure to Air Pollution and Biomarkers Related to Insulin Resistance, Subclinical Inflammation, and Adipokines,” Diabetes 65, no. 11 (2016): 3314–3326.
  • A. O. Lawal, L. M. Davids, and J. L. Marnewick, “Diesel Exhaust Particles and Endothelial Cells Dysfunction: An Update,” Toxicology in Vitro: An International Journal Published in Association with BIBRA 32 (2016): 92–104.
  • J. Øvrevik, M. Refsnes, M. Låg, J. A. Holme, and P. E. Schwarze, “Activation of Proinflammatory Responses in Cells of the Airway Mucosa by Particulate Matter: oxidant- and Non-Oxidant-Mediated Triggering Mechanisms,” Biomolecules 5, no. 3 (2015): 1399–440.
  • A. I. Totlandsdal, J. I. Herseth, A. K. Bølling, A. Kubátová, A. Braun, R. E. Cochran, M. Refsnes, J. Ovrevik, and M. Låg, “Differential Effects of the Particle Core and Organic Extract of Diesel Exhaust Particles,” Toxicology Letters 208, no. 3 (2012): 262–268.
  • F. Yin, A. Lawal, J. Ricks, J. R. Fox, T. Larson, M. Navab, A. M. Fogelman, M. E. Rosenfeld, and J. A. Araujo, “Diesel Exhaust Induces Systemic Lipid Peroxidation and Development of Dysfunctional Pro-Oxidant and Pro-Inflammatory High-Density Lipoprotein,” Arteriosclerosis, Thrombosis, and Vascular Biology 33, no. 6 (2013): 1153–1161.
  • A. O. Lawal, “Diesel Exhaust Particles and the Induction of Macrophage Activation and Dysfunction,” Inflammation 41, no. 1 (2018): 356–363.
  • M. R. Miller, S. G. McLean, R. Duffin, A. O. Lawal, J. A. Araujo, C. A. Shaw, N. L. Mills, K. Donaldson, D. E. Newby, and P. W. F. Hadoke, “Diesel Exhaust Particulate Increases the Size and Complexity of Lesions in Atherosclerotic Mice,” Particle and Fibre Toxicology 10 (2013): 61.
  • Angélica Montiel-Dávalos, María de Jesús Ibarra-Sánchez, José Luis Ventura-Gallegos, Ernesto Alfaro-Moreno, and Rebeca López-Marure, “Oxidative Stress and Apoptosis Are Induced in Human Endothelial Cells Exposed to Urban Particulate Matter,” Toxicology in Vitro 24, no. 1 (2010): 135–141.
  • S. Tobwala, X. Zhang, Y. Zheng, H. Wang, W. A. Banks, and N. Ercal, “Disruption of the Integrity and Function of Brain Microvascular Endothelial Cells in Culture by Exposure to Diesel Engine Particles,” Toxicology Letters 220, no. 1 (2013): 1–7.
  • C. Y. Tseng, J. S. Wang, Y. J. Chang, J. F. Chang, and M. W. Chao, “Exposure to High-Dose Diesel Exhaust Particles Induces Intracellular Oxidative Stress and Causes Endothelial Apoptosis in Cultured in Vitro Capillary Tube Cells,” Cardiovascular Toxicology 15, no. 4 (2015): 345–354.
  • H. Frikke-Schmidt, M. Roursgaard, J. Lykkesfeldt, S. Loft, J. K. Nøjgaard, and P. Møller, “Effect of Vitamin C and Iron Chelation on Diesel Exhaust Particle and Carbon Black Induced Oxidative Damage and Cell Adhesion Molecule Expression in Human Endothelial Cells,” Toxicology Letters 203, no. 3 (2011): 181–189.
  • A. O. Lawal, L. M. Davids, L. Jeanine, and J. L. Marnewick, “Rooibos (Aspalathus Linearis) and Honeybush (Cyclopia Species) Modulate the Oxidative Stress Associated Injury of Diesel Exhaust Particles in Human Umbilical Vein Endothelial Cells,” Phytomedicine 59 (2019): 152898.
  • Langying Ou, Akiko Honda, Natsuko Miyasaka, Sakiko Akaji, Issei Omori, Raga Ishikawa, Yinpeng Li, Kayo Ueda, and Hirohisa Takano, “Application of Three-Dimensional Raman Imaging to Determination of the Relationship between Cellular Localization of Diesel Exhaust Particles and the Toxicity,” Toxicology Mechanisms and Methods 32, no. 5 (2022): 333–340.
  • J. Madrigano, I. Kloog, R. Goldberg, B. A. Coull, M. A. Mittleman, and J. Schwartz, “Long-Term Exposure to PM2.5 and Incidence of Acute Myocardial Infarction,” Environmental Health Perspectives 121, no. 2 (2013): 192–196.
  • O. M. Palomino, N. M. Gouveia, S. Ramos, M. A. Martin, and L. Goya, “Protective Effect of Silybum Marianum and Silibinin on Endothelial Cells Submitted to High Glucose Concentration,” Planta Medica 83, no. 1-02 (2017): 97–103.
  • Y. Han, H. W. Jung, and Y. K. Park, “Effects of Icariin on Insulin Resistance via the Activation of AMPK Pathway in C2C12 Mouse Muscle Cells,” European Journal of Pharmacology 758 (2015): 60–63.
  • Kyoung Min Kim, Kuy-Sook Lee, Gha Young Lee, Hyunjin Jin, Eunice Sung Durrance, Ho Seon Park, Sung Hee Choi, Kyong Soo Park, Young-Bum Kim, Hak Chul Jang, et al., “Anti-Diabetic Efficacy of KICG1338, a Novel Glycogen Synthase Kinase-3β Inhibitor, and Its Molecular Characterization in Animal Models of Type 2 Diabetes and Insulin Resistance,” Molecular and Cellular Endocrinology 409 (2015): 1–10.
  • H. Koepsell, “Glucose Transporters in Brain in Health and Disease,” Pflügers Archiv - European Journal of Physiology 472, no. 9 (2020): 1299–1343.
  • G. Zhou, R. Myers, Y. Li, Y. Chen, X. Shen, J. Fenyk-Melody, M. Wu, J. Ventre, T. Doebber, N. Fujii, et al., “Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action,” The Journal of Clinical Investigation 108, no. 8 (2001): 1167–1174. 2013):
  • S. C. Lin, and D. G. Hardie, “AMPK: sensing Glucose as Well as Cellular Energy Status,” Cell Metabolism 27, no. 2 (2018): 299–313.
  • Joo-Man Park, Tae-Hyun Kim, Jin-Sik Bae, Mi-Young Kim, Kyung-Sup Kim, and Yong-Ho Ahn, “Role of Resveratrol in FOXO1-Mediated Gluconeogenic Gene Expression in the Liver,” Biochemical and Biophysical Research Communications 403, no. 3-4 (2010): 329–334.
  • Jiayin Yao, Min Zhi, Xiang Gao, Pinjin Hu, Chujun Li, and Xiaobo Yang, “Effect and the Probable Mechanisms of Silibinin in Regulating Insulin Resistance in the Liver of Rats with Non-Alcoholic Fatty Liver,” Brazilian Journal of Medical and Biological Research = Revista Brasileira de Pesquisas Medicas e Biologicas 46, no. 3 (2013): 270–277.
  • A. O. Lawal, D. M. Oluyede, M. O. Adebimpe, L. T. Olumegbon, O. O. Awolaja, O. O. Elekofehinti, and O. O. Crown, “The Cardiovascular Protective Effects of Rooibos (Aspalathus Linearis) Extract on Diesel Exhaust Particles Induced Inflammation and Oxidative Stress Involve NF-kB and Nrf2-Dependent Pathways Modulation,” Heliyon 5, no. 3 (2019): e01426.
  • Marília F. Manchope, Cássia Calixto-Campos, Letícia Coelho-Silva, Ana C. Zarpelon, Felipe A. Pinho-Ribeiro, Sandra R. Georgetti, Marcela M. Baracat, Rúbia Casagrande, and Waldiceu A. Verri, Jr, “Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2, and the NO − cGMP − PKG –KATP Channel Signaling Pathway,” PLoS ONE 11, no. 4 (2016): e0153015.

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