Isoniazid: A Review of Characteristics, Properties and Analytical Methods

References

• Adaway, J. E.; Keevil, B. G.; Owen, L. J. Liquid Chromatography Tandem Mass Spectrometry in the Clinical Laboratory. Ann. Clin. Biochem. 2015, 52(1), 18–38.
   PubMed Web of Science ®Google Scholar
• Agrawal, S.; Singh, I.; Kaur, K. J.; Bhade, S. R.; Kaul, C. L.; Panchagnula, R. Assessment of Bioequivalence of Rifampicin, Isoniazid and Pyrazinamide in a Four Drug Fixed Dose Combination with Separate Formulations at the Same Dose Levels. Int. J. Pharm. (Amsterdam, Neth.) 2002, 233, 169–177.
   PubMed Web of Science ®Google Scholar
• Alfonsi, K.; Colberg, J.; Dunn, P. J.; Fevig, T.; Jennings, S.; Johnson, T. A.; Kleine, H. P.; Knight, C.; Nagy, M. A.; Perry, D. A.; Stefaniak, M. Green Chemistry Tools to Influence a Medicinal Chemistry and Research Chemistry Based Organisation. Green Chem. 2008, 10 (1), 31–36.
   Web of Science ®Google Scholar
• Ayyappan, J.; Umapathi, P.; Quine, S. D. Development and Validation of a Stability Indicating High-Performance Liquid Chromatography (HPLC) Method for the Estimation of Isoniazid and Its Related Substances in Fixed Dose Combination of Isoniazid and Ethambutol Hydrochloride Tablets. Afr. J. Pharm. Pharmacol. 2011, 5 (12), 1513–1521.
   Google Scholar
• Bailey, L. C.; Abdou, H. High-Performance Liquid Chromatographic Analysis of Isoniazid and Its Dosage Forms. J. Pharm. Sci. 1977, 66 (4), 564–567.
   PubMed Web of Science ®Google Scholar
• Baldrey, S. F.; Brodie, R. R.; Morris, G. R.; Jenkins, E. H.; Brookes, S. T. Comparison of LC-UV and LC-MS-MS for the Determination of Taxol. Chromatographia 2002, 55, S187–S192.
   Web of Science ®Google Scholar
• Bardou, F.; Raynaud, C.; Ramos, C.; Lanéelle, M. A.; Lanéelle, G. Mechanism of Isoniazid Uptake in Mycobacterium Tuberculosis. Microbiology 1998, 144 (9), 2539–2544.
   PubMed Web of Science ®Google Scholar
• Berchtold, C.; Bosilkovska, M.; Daali, Y.; Walder, B.; Zenobi, R. Real-Time Monitoring of Exhaled Drugs by Mass Spectrometry. Mass Spectrom. Rev. 2014, 33 (5), 394–413.
   PubMed Web of Science ®Google Scholar
• Bernstein, J.; Lott, W. A.; Steinberg, B. A.; Yale, H. L. Chemotherapy of Experimental Tuberculosis. V. Isonicotinic Acid Hydrazide (Nydrazid) and Related Compounds. Am. Rev. Tuberc. 1952, 65 (4), 357–364.
   PubMedGoogle Scholar
• Blanchard, J. S. Molecular Mechanisms of Drug Resistance in Tuberculosis. Annu. Rev. Biochem 1996, 65, 215–239.
   PubMed Web of Science ®Google Scholar
• De Bleye, C.; Chavez, P. F.; Mantanus, J.; Marini, R.; Hubert, P.; Rozet, E.; Ziemons, E. Critical Review of near-Infrared Spectroscopic Methods Validations in Pharmaceutical Applications. J. Pharm. Biomed. Anal. 2012, 69, 125–132.
   PubMed Web of Science ®Google Scholar
• Bonfilio, R.; de Araújo, M. B.; Salgado, H. R. N. Recent Applications of Analytical Techniques for Quantitative Pharmaceutical Analysis: A Review. WSEAS Trans. Biol. Biomed. 2010, 7 (4), 316–338.
   Google Scholar
• Bonfilio, R.; Cazedey, E. C. L.; de Araújo, M. B.; Salgado, H. R. N. Analytical Validation of Quantitative High-Performance Liquid Chromatographic Methods in Pharmaceutical Analysis: A Practical Approach. Crit. Rev. Anal. Chem. 2012, 42 (1), 87–100.
   Web of Science ®Google Scholar
• BRASIL. Brazilian Pharmacopoeia; Brasília, 2010; 2.
   Google Scholar
• BRASIL. Manual de Recomendações Para O Controle Da Tuberculose No Brasil; 2011.
   Google Scholar
• BRASIL. Boletim Epidemiológico 2016 - Perspectivas Brasileiras Para O Fim Da Tuberculose Como Problema de Saúde Pública; 2016; 47.
   Google Scholar
• Bridwell, H.; Dhingra, V.; Peckman, D.; Roark, J.; Lehman, T. Perspectives on Method Validation: Importance of Adequate Method Validation. Qual. Assur. J. 2010, 13, 72–77.
   Google Scholar
• Butterfield, A. G.; Lovering, E. G.; Sears, R. W. High-Performance Liquid Chromatographic Determination of Isoniazid and 1-Isonicotinyl-2-Lactosylhydrazine in Isoniazid Tablet Formulations. J. Pharm. Sci. 1980, 69 (2), 222–224.
   PubMed Web of Science ®Google Scholar
• Byrne, F. P.; Jin, S.; Paggiola, G.; Petchey, T. H. M.; Clark, J. H.; Farmer, T. J.; Hunt, A. J.; McElroy, C. R.; Sherwood, J. Tools and Techniques for Solvent Selection: Green Solvent Selection Guides. Sustain. Chem. Process. 2016, 4 (7), 1–24.
   Google Scholar
• Calleri, E.; De Lorenzi, E.; Furlanetto, S.; Massolini, G.; Caccialanza, G. Validation of a RP-LC Method for the Simultaneous Determination of Isoniazid, Pyrazinamide and Rifampicin in a Pharmaceutical Formulation. J. Pharm. Biomed. Anal. 2002, 29 (6), 1089–1096.
   PubMed Web of Science ®Google Scholar
• Capello, C.; Fischer, U.; Hungerbühler, K. What Is a Green Solvent? A Comprehensive Framework for the Environmental Assessment of Solvents. Green Chem. 2007, 9, 927–934.
   Web of Science ®Google Scholar
• Chellini, P. R.; Lages, E. B.; Franco, P. H. C.; Nogueira, F. H. A.; César, I. C.; Pianetti, G. A. Development and Validation of an HPLC Method for Simultaneous Determination of Rifampicin, Isoniazid, Pyrazinamide, and Ethambutol Hydrochloride in Pharmaceutical Formulations. J. AOAC Int. 2015, 98 (5), 1234–1239.
   PubMed Web of Science ®Google Scholar
• Chen, X.; Song, B.; Jiang, H.; Yu, K.; Zhong, D. A Liquid Chromatography/tandem Mass Spectrometry Method for the Simultaneous Quantification of Isoniazid and Ethambutol in Human Plasma. Rapid Commun. Mass Spectrom. 2005, 19 (18), 2591–2596.
   PubMed Web of Science ®Google Scholar
• Chierentin, L.; Salgado, H. R. N. Review of Properties and Analytical Methods for the Determination of Norfloxacin. Crit. Rev. Anal. Chem. 2016, 46 (1), 23–39.
   Web of Science ®Google Scholar
• Corrêa, J. C. R.; Salgado, H. R. N. Review of Fluconazole Properties and Analytical Methods for Its Determination. Crit. Rev. Anal. Chem. 2011, 41 (3), 270–279.
   Web of Science ®Google Scholar
• Curbete, M. M.; Salgado, H. R. N. A Critical Review of the Properties of Fusidic Acid and Analytical Methods for Its Determination. Crit. Rev. Anal. Chem. 2016, 46 (4), 352–360.
   PubMed Web of Science ®Google Scholar
• Curzons, A. D.; Constable, D. C.; Cunningham, V. L. Solvent Selection Guide: A Guide to the Integration of Environmental, Health and Safety Criteria into the Selection of Solvents. Clean Prod. Process. 1999, 1 (2), 82–90.
   Google Scholar
• Daher, A.; Pitta, L.; Santos, T.; Barreira, D.; Pinto, D. Using a Single Tablet Daily to Treat Latent Tuberculosis Infection in Brazil: Bioequivalence of Two Different Isoniazid Formulations (300 Mg and 100 Mg) Demonstrated by a Sensitive and Rapid High-Performance Liquid Chromatography-Tandem Mass Spectrometry. Mem. Inst. Oswaldo Cruz. 2015a, 110 (4), 543–550.
   PubMed Web of Science ®Google Scholar
• Daher, A.; Pitta, L.; Santos, T.; Barreira, D.; Pinto, D. Using a Single Tablet Daily to Treat Latent Tuberculosis Infection in Brazil: Bioequivalence of Two Different Isoniazid Formulations (300 Mg and 100 Mg) Demonstrated by a Sensitive and Rapid High-Performance Liquid Chromatography-Tandem Mass Spectrometry. Mem. Inst. Oswaldo Cruz 2015b, 110 (4), 543–550.
   PubMed Web of Science ®Google Scholar
• Deretic, V.; Pagán-Ramos, E.; Zhang, Y.; Dhandayuthapani, S.; Via, L. E. The Extreme Sensitivity of Mycobacterium Tuberculosis to the Front-Line Antituberculosis Drug Isoniazid. Nat. Biotechnol. 1996, 14 (11), 1557–1561.
   PubMed Web of Science ®Google Scholar
• Dhal, S. K.; Sharma, R. Development and Validation of RP – HPLC Method for Simultaneous Determination of Pyridoxine Hydrochloride, Isoniazid, Pyrazinamide and Rifampicin in Pharmaceutical Formulation. Chem. Anal. (Warsaw, Pol.) 2009, 1487, 1487–1500.
   Google Scholar
• Dunn, P. J. The Importance of Green Chemistry in Process Research and Development. Chem. Soc. Rev. 2012, 41 (4), 1452–1461.
   PubMed Web of Science ®Google Scholar
• Durand, F.; Jebrak, G.; Pessayre, D.; Fournier, M.; Bernuau, J. Hepatotoxicity of Antitubercular Treatments. Drug Saf. 1996, 15 (6), 394–405.
   PubMed Web of Science ®Google Scholar
• Ellard, G. A.; Gammon, P. T. Pharmacokinetics of Isoniazid Metabolism in Man. J. Pharmacokinet. Biopharm. 1976, 4 (2), 83–113.
   PubMedGoogle Scholar
• Ellard, G. A.; Gammon, P. T.; Wallace, S. M. The Determination of Isoniazid and Its Metabolites Acetylisoniazid, Monoacetylhydrazine, Diacetylhydrazine, Isonicotinic Acid and Isonicotinylglycine in Serum and Urine. Biochem. J. 1972, 126 (3), 449–458.
   PubMed Web of Science ®Google Scholar
• Fang, P.-F.; Cai, H.-L.; Li, H.-D.; Zhu, R.-H.; Tan, Q.-Y.; Gao, W.; Xu, P.; Liu, Y.-P.; Zhang, W.-Y.; Chen, Y.-C.; Zhang, F. Simultaneous Determination of Isoniazid, Rifampicin, Levofloxacin in Mouse Tissues and Plasma by High Performance Liquid Chromatography-Tandem Mass Spectrometry. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2010, 878 (24), 2286–2291.
   PubMed Web of Science ®Google Scholar
• Fernandes, F. H. A.; Salgado, H. R. N. Gallic Acid: Review of the Methods of Determination and Quantification. Crit. Rev. Anal. Chem. 2016, 46 (3), 257–265.
   PubMed Web of Science ®Google Scholar
• Fernandes, G. F.; Souza, P. C.; Marino, L. B.; Chegaev, K.; Gugliemo, S.; Lazzarato, L.; Fruttero, R.; Chung, M. C.; Pavan, F. R.; Santos, J. L. Synthesis and Biological Activity of Furoxan Derivatives against Mycobacterium Tuberculosis. Eur. J. Med. Chem. 2016, 123, 523–531.
   PubMed Web of Science ®Google Scholar
• Fountain, F. F.; Tolley, E.; Chrisman, C. R.; Self, T. H. Isoniazid Hepatotoxicity Associated With Treatment of Latent Tuberculosis Infection. Chest 2005, 128 (1), 116–123.
   PubMed Web of Science ®Google Scholar
• Fox, H. H. The Chemical Approach to the Control of Tuberculosis. Science (80-. ). 1952, 116 (3006), 129–134.
   PubMed Web of Science ®Google Scholar
• Garg, U.; Zhang, Y. V. Mass Spectrometry in Clinical Laboratory: Applications in Biomolecular Analysis. Methods Mol. Biol. 2016, 1378, 1–9.
   PubMedGoogle Scholar
• Ghosh, C. Green Bioanalysis: Some Innovative Ideas towards Green Analytical Techniques. Bioanalysis 2012, 4 (11), 1377–1391.
   PubMed Web of Science ®Google Scholar
• Glass, B. D.; Agatonovic-Kustrin, S.; Chen, Y.-J.; Wisch, M. H. Optimization of a Stability-Indicating HPLC Method for the Simultaneous Determination of Rifampicin, Isoniazid, and Pyrazinamide in a Fixed-Dose Combination Using Artificial Neural Networks. J. Chromatogr. Sci. 2007, 45 (1), 38–44.
   PubMed Web of Science ®Google Scholar
• Global Alliance for TB Drug Development. Handbook of Anti-Tuberculosis Agents. Tuberculosis 2008, 88 (2), 85–170.
   PubMed Web of Science ®Google Scholar
• Hanna-Brown, M. Pharmaceutical Analysis. Anal. Methods 2012, 4 (6), 1484–84.
   Web of Science ®Google Scholar
• Hanser-Jr, E. B.; Dooley, K. L.; Thompson-Jr, H. C. High-Performance Liquid Chromatographic Analysis of the Antituberculosis Drugs Aconiazide and Isoniazid. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 1995, 670, 259–266.
   Web of Science ®Google Scholar
• Hashiguchi, M.; Ohno, K.; Sakuma, A.; Hino, F.; Tanaka, T.; Ohtsuji, M.; Matsumoto, N.; Yanase, K.; Urae, A.; Hosogai, Y.; Sato, N.; Yazaki, A.; Matsuda, K.; Yamazaki, K.; Rikihisa, T. A Simplified Method for Detecting Isoniazid Compliance in Patients Receiving Antituberculosis Chemotherapy. J. Clin. Pharmacol. 2002, 42, 151–156.
   PubMed Web of Science ®Google Scholar
• Hee, K. H.; Seo, J. J.; Lee, L. S. Development and Validation of Liquid Chromatography Tandem Mass Spectrometry Method for Simultaneous Quantification of First Line Tuberculosis Drugs and Metabolites in Human Plasma and Its Application in Clinical Study. J. Pharm. Biomed. Anal. 2015, 102, 253–260.
   PubMed Web of Science ®Google Scholar
• Henderson, R. K.; Jiménez-González, C.; Constable, D. J. C.; Alston, S. R.; Inglis, G. G. A.; Fisher, G.; Sherwood, J.; Binks, S. P.; Curzons, A. D. Expanding GSK's Solvent Selection Guide – Embedding Sustainability into Solvent Selection Starting at Medicinal Chemistry. Green Chem. 2011, 4, 854–862.
   Web of Science ®Google Scholar
• Hutchings, A.; Monie, R. D.; Spragg, B.; Routledge, P. A. High-Performance Liquid Chromatographic Analysis of Isoniazid and Acetylisoniazid in Biological Fluids. J. Pharm. Sci. 1977, 66 (6), 813–816.
   PubMed Web of Science ®Google Scholar
• Hutchings, A.; Monie, R. D.; Spragg, B.; Routledge, P. A. High-Performance Liquid Chromatographic Analysis of Isoniazid and Acetylisoniazid in Biological Fluids. J. Chromatogr. B Biomed. Sci. Appl. 1983, 277, 385–390.
   Web of Science ®Google Scholar
• Jacobs, R. F.; Wilson, C. B. Intracellular Penetration and Antimicrobial Activity of Antibiotics. J. Antimicrob. Chemother. 1983, 12, 13–20.
   PubMed Web of Science ®Google Scholar
• Jagielski, T.; Baku a, Z.; Roeske, K.; Kami ski, M.; Napiorkowska, A.; Augustynowicz-Kope, E.; Zwolska, Z.; Bielecki, J. Detection of Mutations Associated with Isoniazid Resistance in Multidrug-Resistant Mycobacterium Tuberculosis Clinical Isolates. J. Antimicrob. Chemother. 2014, 69 (9), 2369–2375.
   PubMed Web of Science ®Google Scholar
• Jayaram, R.; Shandil, R. K.; Gaonkar, S.; Kaur, P.; Suresh, B. L.; Mahesh, B. N.; Jayashree, R.; Nandi, V.; Bharath, S.; Kantharaj, E.; Balasubramanian, V. Isoniazid Pharmacokinetics-Pharmacodynamics in an Aerosol Infection Model of Tuberculosis. Antimicrob. Agents Chemother. 2004, 48 (8), 2951–2957.
   PubMed Web of Science ®Google Scholar
• Johnston, A.; Holt, D. W. Substandard Drugs: A Potential Crisis for Public Health. Br. J. Clin. Pharmacol. 2014, 78 (2), 218–243.
   PubMed Web of Science ®Google Scholar
• Khuhawar, M. Y.; Rind, F. M. A. Liquid Chromatographic Determination of Isoniazid, Pyrazinamide and Rifampicin from Pharmaceutical Preparations and Blood. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2002, 766, 357–363.
   PubMed Web of Science ®Google Scholar
• Khuhawar, M. Y.; Rind, F. M. A.; Rajper, A. D. High-Performance Liquid Chromatography Determination of Isoniazid, Pyrazinamide, and Indomethacin in Pharmaceutical Prepatarions. Acta Chromatogr. 2005, 15, 269–275.
   Web of Science ®Google Scholar
• Koga, H. High-Performance Liquid Chromatography Measurement of Antimicrobial Concentrations in Polymorphonuclear Leukocytes. Antimicrob. Agents Chemother. 1987, 31 (12), 1904–1908.
   PubMed Web of Science ®Google Scholar
• Kumar, D.; Beena,  ; Khare, G.; Kidwai, S.; Tyagi, A. K.; Singh, R.; Rawat, D. S. Synthesis of Novel 1,2,3-Triazole Derivatives of Isoniazid and Their in Vitro and in Vivo Antimycobacterial Activity Evaluation. Eur. J. Med. Chem. 2014, 81, 301–313.
   PubMed Web of Science ®Google Scholar
• Lee, D. C.; Webb, M. L. Pharmaceutical Analysis; Blackwell Publishing Ltd: Oxford, 2003.
   Google Scholar
• Liu, P.; Fu, Z.; Jiang, J.; Yuan, L.; Lin, Z. Determination of Isoniazid Concentration in Rabbit Vertebrae by Isotope Tracing Technique in Conjunction with HPLC. Biomed. Chromatogr. 2013, 27 (9), 1150–1156.
   PubMed Web of Science ®Google Scholar
• Marrakchi, H.; Lanéelle, G.; Quémard, A. InhA, a Target of the Antituberculous Drug Isoniazid, Is Involved in a Mycobacterial Fatty Acid Elongation System, FAS-II. Microbiology 2000, 146 (2), 289–296.
   PubMed Web of Science ®Google Scholar
• Marshall, S. G.; Crofton, J. W.; Cruickshank, R.; Daniels, M.; Geddes, J. E.; Heaf, F. R. G.; Hill, A. B.; Hurford, J. V.; Mitchison, D. A.; Paton, W. D. M.; Scadding, J. G.; Smith, N.; Hart, P. D. A. The Treatment of Pulmonary Tuberculosis with Isoniazid - an Interim Report to the Medical Research Council by Their Tuberculosis Chemotherapy Trials Committee. Br. Med. J. 1952, 2 (4787), 736–746.
   Google Scholar
• Martins, F.; Santos, S.; Ventura, C.; Elvas-Leitão, R.; Santos, L.; Vitorino, S.; Reis, M.; Miranda, V.; Correia, H. F.; Aires-de-Sousa, J.; Kovalishyn, V.; Latino, D. A. R. S.; Ramos, J.; Viveiros, M. Design, Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity. Eur. J. Med. Chem. 2014, 81, 119–138.
   PubMed Web of Science ®Google Scholar
• Matei, L.; Bleotu, C.; Baciu, I.; Draghici, C.; Ionita, P.; Paun, A.; Chifiriuc, M.; Sbarcea, A.; Zarafu, I. Synthesis and Bioevaluation of Some New Isoniazid Derivatives. Bioorg. Med. Chem. 2013, 21 (17), 5355–5361.
   PubMed Web of Science ®Google Scholar
• McIlleron, H.; Rustomjee, R.; Vahedi, M.; Mthiyane, T.; Denti, P.; Connolly, C.; Rida, W.; Pym, A.; Smith, P. J.; Onyebujohc, P. C. Reduced Antituberculosis Drug Concentrations in HIV-Infected Patients Who Are Men or Have Low Weight: Implications for International Dosing Guidelines. Antimicrob. Agents Chemother. 2012, 56 (6), 3232–3238.
   PubMed Web of Science ®Google Scholar
• Medical Research Council. Changes in Isoniazid Resistance of Tubercle Bacilli After Cessation of Treatment. Thorax 1954, 9, 254–259.
   PubMed Web of Science ®Google Scholar
• Moussa, L. A.; Khassouani, C. E.; Soulaymani, R.; Jana, M.; Cassanas, G.; Alric, R.; Hüe, B. Therapeutic Isoniazid Monitoring Using a Simple High-Performance Liquid Chromatographic Method with Ultraviolet Detection. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2001, 766, 181–187.
   Web of Science ®Google Scholar
• National Center for Biotechnology Information. PubChem Compound Database; CID=3767, 2016.
   Google Scholar
• Ng, K. yun; Zhou, H.; Zhang, Y. L.; Hybertson, B.; Randolph, T.; Christians, U. Quantification of Isoniazid and Acetylisoniazid in Rat Plasma and Alveolar Macrophages by Liquid Chromatography-Tandem Mass Spectrometry with on-Line Extraction. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2007, 847 (2), 188–198.
   PubMed Web of Science ®Google Scholar
• O'Neil, M. J. The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals, 13th ed.; Merck and Co., Inc.: Whitehouse Station, NJ, 2001.
   Google Scholar
• Pasáková, I.; Gladziszová, M.; Charvátová, J.; Stariat, J.; Klimeš, J.; Kovaříková, P. Use of Different Stationary Phases for Separation of Isoniazid, Its Metabolites and Vitamin B6 Forms. J. Sep. Sci. 2011, 34 (12), 1357–1365.
   PubMed Web of Science ®Google Scholar
• Patel, Y. P.; Shah, N.; Bhoir, I. C.; Sundaresan, M. Simultaneous Determination of Five Antibiotics by Ion-Pair High-Performance Liquid Chromatography. J. Chromatogr. A 1998, 828, 287–290.
   Web of Science ®Google Scholar
• Pedroso, T. M.; Salgado, H. R. N. A Critical Review of Analytical Methods for Determination of Ertapenem Sodium. Crit. Rev. Anal. Chem. 2016, 46 (1), 15–21.
   PubMed Web of Science ®Google Scholar
• Płotka, J.; Tobiszewski, M.; Sulej, A. M.; Kupska, M.; Górecki, T.; Namieś nik, J. Green Chromatography. J. Chromatogr. A 2013, 13, 1–20.
   Web of Science ®Google Scholar
• Pouplin, T.; Bang, N. D.; Van Toi, P.; Phuong, P. N.; Dung, N. H.; Duong, T. N.; Caws, M.; Thwaites, G. E.; Tarning, J.; Day, J. N. Naïve-Pooled Pharmacokinetic Analysis of Pyrazinamide, Isoniazid and Rifampicin in Plasma and Cerebrospinal Fluid of Vietnamese Children with Tuberculous Meningitis. BMC Infect. Dis. 2016, 16 (144), 1–13.
   PubMed Web of Science ®Google Scholar
• Preziosi, P. Isoniazid: Metabolic Aspects and Toxicological Correlates. Curr. Drug Metab. 2007, 8 (8), 839–851.
   PubMed Web of Science ®Google Scholar
• Prokesch, R. C.; Hand, W. L. Antibiotic Entry into Human Polymorphonuclear Leukocytes. Antimicrob. Agents Chemother. 1982, 21 (3), 373–380.
   PubMed Web of Science ®Google Scholar
• Rangaka, M..; Wilkinson, R..; Boulle, A.; Glynn, J..; Fielding, K.; van Cutsem, G.; Wilkinson, K..; Goliath, R.; Mathee, S.; Goemaere, E.; Maartens, G. Isoniazid plus Antiretroviral Therapy to Prevent Tuberculosis: A Randomised Double-Blind, Placebo-Controlled Trial. Lancet 2014, 384, 682–690.
   PubMed Web of Science ®Google Scholar
• Roškar, R.; Lušin, T. T. Analytical Methods for Quantification of Drug Metabolites in Biological Samples. In Chromatography: Most Versatile Method of Chemical Analysis; Calderon, L. de A., Ed.; InTech: Rijeka, 2012; pp 79–126.
   Google Scholar
• Sadeg, N.; Pertat, N.; Dutertre, H.; Dumontet, M. Rapid, Specific and Sensitive Method for Isoniazid Determination in Serum. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 1996, 675, 113–117.
   Web of Science ®Google Scholar
• Sahai, J.; Gallicano, K.; Swick, L.; Tailor, S.; Garber, G.; Seguin, I.; Oliveras, L.; Walker, S.; Rachlis, A.; Cameron, D. W. Reduced Plasma Concentrations of Antituberculosis Drugs in Patients with HIV Infection. Ann. Intern. Med. 1997, 127 (4), 289–293.
   PubMed Web of Science ®Google Scholar
• Von Sassen, W.; Castro-Parra, M.; Musch, E.; Eichelbaum, M. Determination of Isoniazid, Acetylisoniazid, Acetylhydrazine and Diacetylhydrazine in Biological Fluids by High-Performance Liquid Chromatography. J. Chromatogr. B Biomed. Sci. Appl. 1985, 338, 113–122.
   Web of Science ®Google Scholar
• Schito, M.; Migliori, G. B.; Fletcher, H. a.; McNerney, R.; Centis, R.; D'Ambrosio, L.; Bates, M.; Kibiki, G.; Kapata, N.; Corrah, T.; Bomanji, J.; Vilaplana, C.; Johnson, D.; Mwaba, P.; Maeurer, M.; Zumla, A. Perspectives on Advances in Tuberculosis Diagnostics, Drugs, and Vaccines. Clin. Infect. Dis. 2015, 61, S102–S118.
   PubMed Web of Science ®Google Scholar
• Scior, T.; Meneses Morales, I.; Garcés Eisele, S. J.; Domeyer, D.; Laufer, S. Antitubercular Isoniazid and Drug Resistance of Mycobacterium Tuberculosis – A Review. Arch. Pharm. Pharm. Med. Chem. 2002, 335 (11–12), 511–525.
   PubMed Web of Science ®Google Scholar
• Seifart, H. I.; Kruger, P. B.; Parkin, D. P.; van Jaarsveld, P. P.; Donald, P. R. Therapeutic Monitoring of Antituberculosis Drugs by Direct in-Line Extraction on a High-Performance Liquid Chromatography System. J. Chromatogr. B Biomed. Sci. Appl. 1993, 619 (2), 285–290.
   Web of Science ®Google Scholar
• Seifart, H. I.; Gent, W. L.; Parkin, D. P.; van Jaarsveld, P. P.; Donald, P. R. High-Performance Liquid Chromatographic Determination of Isoniazid, Acetylisoniazid and Hydrazine in Biological Fluids. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 1995, 674, 269–275.
   Web of Science ®Google Scholar
• Senousy, B. E.; Belal, S. I.; Draganov, P. V. Hepatotoxic Effects of Therapies for Tuberculosis. Nat. Rev. Gastroenterol. Hepatol. 2010, 7 (10), 543–556.
   PubMed Web of Science ®Google Scholar
• Shekar, S.; Yeo, Z. X.; Wong, J. C. L.; Chan, M. K. L.; Ong, D. C. T.; Tongyoo, P.; Wong, S.-Y.; Lee, A. S. G. Detecting Novel Genetic Variants Associated with Isoniazid-Resistant Mycobacterium Tuberculosis. PLoS One 2014, 9 (7), e102383.
   PubMed Web of Science ®Google Scholar
• Siddiqui, M. R.; AlOthman, Z. A.; Rahman, N. Analytical Techniques in Pharmaceutical Analysis: A Review. Arab. J. Chem. 2013. In press.
   Web of Science ®Google Scholar
• Sittig, M. Pharmaceutical Maufacturing Enclyclopedia, 2nd ed.; Sittig, M., Ed.; Noyes Publications: Westwood, 1988; p 1.
   Google Scholar
• Song, S. H.; Jun, S. H.; Park, K. U.; Yoon, Y.; Lee, J. H.; Kim, J. Q.; Song, J. Simultaneous Determination of First-Line Anti-Tuberculosis Drugs and Their Major Metabolic Ratios by Liquid Chromatography/tandem Mass Spectrometry. Rapid Commun. Mass Spectrom. 2007, 21, 1331–1338.
   PubMed Web of Science ®Google Scholar
• Stennis, N.; Burzynski, J.; Herbert, C.; Nilsen, D.; Macaraig, M. Treatment for Tuberculosis Infection With 3 Months of Isoniazid and Rifapentine in New York City Health Department Clinics. Clin. Infect. Dis. 2016, 62 (1), 53–59.
   PubMed Web of Science ®Google Scholar
• Suneetha, A.; Raja, R. K. Comparison of LC-UV and LC–MS Methods for Simultaneous Determination of Teriflunomide, Dimethyl Fumarate and Fampridine in Human Plasma: Application to Rat Pharmacokinetic Study. Biomed. Chromatogr. 2016, 30, 1371–1377.
   PubMed Web of Science ®Google Scholar
• Svensson, J.-O.; Muchtar, A.; Ericsson, O. Ion-Pair High-Performance Liquid Chromatographic Determination of Isoniazid and Acetylisoniazid in Plasma and Urine. J. Chromatogr. B Biomed. Sci. Appl. 1985, 341, 193–197.
   Web of Science ®Google Scholar
• Sycheva, T. P.; Pavlova, T. N.; Shchukina, M. N. Synthesis of Isoniazid from 4-Cyanopyridine. Pharm. Chem. J. 1972, 6 (11), 696–698.
   Google Scholar
• Timmins, G. S.; Deretic, V. Mechanisms of Action of Isoniazid. Mol. Microbiol. 2006, 62 (5), 1220–1227.
   PubMed Web of Science ®Google Scholar
• Timmins, G. S.; Master, S.; Rusnak, F.; Deretic, V. Requirements for Nitric Oxide Generation from Isoniazid Activation In Vitro and Inhibition of Mycobacterial Respiration In Vivo. J. Bacteriol. 2004, 186 (16), 5427–5431.
   PubMed Web of Science ®Google Scholar
• Tiwari, G.; Tiwari, R. Bioanalytical Method Validation: An Updated Review. Pharm Methods 2010, 1 (1), 25–38.
   PubMedGoogle Scholar
• Tzanavaras, P. D.; Themelis, D. G. Review of Recent Applications of Flow Injection Spectrophotometry to Pharmaceutical Analysis. Anal. Chim. Acta 2007, 588 (1), 1–9.
   PubMed Web of Science ®Google Scholar
• U.S. Pharmacopeial Convention. US Pharmacopeia National Formulary; 2016; p 2.
   Google Scholar
• Vilchèze, C.; Jacobs, W. R. The Mechanism of Isoniazid Killing: Clarity Through the Scope of Genetics. Annu. Rev. Microbiol. 2007, 61, 35–50.
   PubMed Web of Science ®Google Scholar
• Villarino, M.; Scott, N.; Weis, S.; Weiner, M.; Conde, M.; Jones, B.; Nachman, S.; Oliveira, R.; Moro, R.; Shang, N.; Goldberg, S. V.; Sterling, T. R. Treatment for Preventing Tuberculosis in Children and Adolescents: A Randomized Clinical Trial of a 3-Month, 12-Dose Regimen of a Combination of Rifapentine and Isoniazid. JAMA Pediatr. 2015, 169 (3), 247–255.
   PubMed Web of Science ®Google Scholar
• Vogt, F. G.; Kord, A. S. Development of Quality-By-Design Analytical Methods. J. Pharm. Sci. 2011, 100 (3), 797–812.
   PubMed Web of Science ®Google Scholar
• Walubo, A.; Chan, K.; Wong, L. Short Communication Simultaneous Assay for Isoniazid and Hydrazine Metabolite in Plasma and Cerebrospinal Fluid in the Rabbit. J. Chromatogr. B Biomed. Sci. Appl. 1991, 567, 261–266.
   Web of Science ®Google Scholar
• Wang, H.; Cai, C.; Chu, C.; Liu, J.; Kong, Y.; Zhu, M.; Zhang, T. A Simple and Rapid HPLC/UV Method for Simultaneous Quantification of Four Constituents in Anti-Tuberculosis 4-FDC Tablets by Pre-Column Derivatization Huan. Asian J. Pharm. Sci. 2012, 7 (4), 303–309.
   Google Scholar
• Weber, W. W.; Hein, D. W. Clinical Pharmacokinetics of Isoniazid. Clin. Pharmacokinet. 1979, 4 (6), 401–422.
   PubMed Web of Science ®Google Scholar
• Wen, B.; Zhu, M. Applications of Mass Spectrometry in Drug Metabolism: 50 Years of Progress. Drug Metab. Rev. 2015, 47 (1), 71–87.
   PubMed Web of Science ®Google Scholar
• Wengenack, N. L.; Rusnak, F. Evidence for Isoniazid-Dependent Free Radical Generation Catalyzed by Mycobacterium Tuberculosis KatG and the Isoniazid-Resistant Mutant KatG(S315T). Biochemistry 2001, 40 (30), 8990–8996.
   PubMed Web of Science ®Google Scholar
• World Health Organization. Quality Assurance of Pharmaceuticals: A Compendium of Guidelines and Related Materials; 2007.
   Google Scholar
• World Health Organization. The Global Plan to Stop TB 2011–2015: Transforming the Fight toward Elimination of Tuberculosis; 2010.
   Google Scholar
• World Health Organization. Global Tuberculosis Report 2014 (WHO/HTM/TB/2014.08); 2014.
   Google Scholar
• World Health Organization. Global Tuberculosis Report; 2015.
   Google Scholar
• Xu, J.; Jin, H.; Zhu, H.; Zheng, M.; Wang, B.; Liu, C.; Chen, M.; Zhou, L.; Zhao, W.; Fu, L.; Lu, Y. Oral Bioavailability of Rifampicin, Isoniazid, Ethambutol, and Pyrazinamide in a 4-Drug Fixed-Dose Combination Compared With the Separate Formulations in Healthy Chinese Male Volunteers. Clin. Ther. 2013, 35 (2), 161–168.
   PubMed Web of Science ®Google Scholar
• Zhang, Y. The Magic Bullets and Tuberculosis Drug Targets. Annu. Rev. Pharmacol. Toxicol. 2005, 45, 529–564.
   PubMed Web of Science ®Google Scholar
• Zhou, Z.; Chen, L.; Liu, P.; Shen, M.; Zou, F. Simultaneous Determination of Isoniazid, Pyrazinamide, Rifampicin and Acetylisoniazid in Human Plasma by High-Performance Liquid Chromatography. Anal. Sci. 2010, 26 (11), 1133–1138.
   PubMed Web of Science ®Google Scholar
• Zumla, A.; Chakaya, J.; Centis, R.; D'Ambrosio, L.; Mwaba, P.; Bates, M.; Kapata, N.; Nyirenda, T.; Chanda, D.; Mfinanga, S.; Hoelscher, M.; Maeurer, M.; Migliori, G. B. Tuberculosis Treatment and Management—an Update on Treatment Regimens, Trials, New Drugs, and Adjunct Therapies. Lancet Respir. Med. 2015, 3 (3), 220–234.
   PubMed Web of Science ®Google Scholar