Gene transfer to promote cardiac regeneration

References

• Bergmann O, Bhardwaj RD, Bernard S, et al. Evidence for cardiomyocyte renewal in humans. Science 2009;324:98–102.
   PubMed Web of Science ®Google Scholar
• Senyo SE, Steinhauser ML, Pizzimenti CL, et al. Mammalian heart renewal by pre-existing cardiomyocytes. Nature 2013;493:433–6.
   PubMed Web of Science ®Google Scholar
• Birks EJ. Molecular changes after left ventricular assist device support for heart failure. Circ Res 2013;113:777–91.
   PubMed Web of Science ®Google Scholar
• Roger VL. Epidemiology of heart failure. Circ Res 2013;113:646–59.
   PubMed Web of Science ®Google Scholar
• Sedmera D, Reckova M, DeAlmeida A, et al. Spatiotemporal pattern of commitment to slowed proliferation in the embryonic mouse heart indicates progressive differentiation of the cardiac conduction system. Anat Rec a Discov Mol Cell Evol Biol 2003;274:773–7.
   PubMedGoogle Scholar
• Collesi C, Zentilin L, Sinagra G, Giacca M. Notch1 signaling stimulates proliferation of immature cardiomyocytes. J Cell Biol 2008;183:117–28.
   PubMed Web of Science ®Google Scholar
• Naqvi N, Li M, Calvert JW, et al. A proliferative burst during preadolescence establishes the final cardiomyocyte number. Cell 2014;157:795–807.
   PubMed Web of Science ®Google Scholar
• Alkass K, Panula J, Westman M, et al. No evidence for cardiomyocyte number expansion in preadolescent mice. Cell 2015;163:1026–36.
   PubMed Web of Science ®Google Scholar
• Soonpaa MH, Zebrowski DC, Platt C, et al. Cardiomyocyte cell-cycle activity during preadolescence. Cell 2015;163:781–2.
   PubMed Web of Science ®Google Scholar
• Porrello ER, Mahmoud AI, Simpson E, et al. Transient regenerative potential of the neonatal mouse heart. Science 2011;331:1078–80.
   PubMed Web of Science ®Google Scholar
• Sadek HA, Martin JF, Takeuchi JK, et al. Multi-investigator letter on reproducibility of neonatal heart regeneration following apical resection. Stem Cell Reports 2014;3:1
   PubMed Web of Science ®Google Scholar
• Oberpriller JO, Oberpriller JC. Response of the adult newt ventricle to injury. J Exp Zool 1974;187:249–53.
   PubMedGoogle Scholar
• Poss KD, Wilson LG, Keating MT. Heart regeneration in zebrafish. Science 2002;298:2188–90.
   PubMed Web of Science ®Google Scholar
• Jopling C, Sleep E, Raya M, et al. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature 2010;464:606–9.
   PubMed Web of Science ®Google Scholar
• Kikuchi K, Holdway JE, Werdich AA, et al. Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. Nature 2010;464:601–5.
   PubMed Web of Science ®Google Scholar
• Zhang R, Han P, Yang H, et al. In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Nature 2013;498:497–501.
   PubMed Web of Science ®Google Scholar
• Zacchigna S, Giacca M. Extra- and intracellular factors regulating cardiomyocyte proliferation in postnatal life. Cardiovasc Res 2014;102:312–20.
   PubMed Web of Science ®Google Scholar
• Giacca M, Zacchigna S. VEGF gene therapy: therapeutic angiogenesis in the clinic and beyond. Gene Ther 2012;19:622–9.
   PubMed Web of Science ®Google Scholar
• Rissanen TT, Yla-Herttuala S. Current status of cardiovascular gene therapy. Mol Ther 2007;15:1233–47.
   PubMed Web of Science ®Google Scholar
• Hedman M, Hartikainen J, Yla-Herttuala S. Progress and prospects: hurdles to cardiovascular gene therapy clinical trials. Gene Ther 2011;18:743–9.
   PubMed Web of Science ®Google Scholar
• Giacca M, Zacchigna S. Virus-mediated gene delivery for human gene therapy. J Control Rel 2012;161:377–88.
   PubMed Web of Science ®Google Scholar
• Yla-Herttuala S, Martin JF. Cardiovascular gene therapy. Lancet 2000;355:213–22.
   PubMed Web of Science ®Google Scholar
• Zacchigna S, Zentilin L, Giacca M. Adeno-associated virus vectors as therapeutic and investigational tools in the cardiovascular system. Circ Res 2014;114:1827–46.
   PubMed Web of Science ®Google Scholar
• Fuchs S, Battler A, Kornowski R. Catheter-based stem cell and gene therapy for refractory myocardial ischemia. Nature Clin Prac Cardiovasc Med 2007;4:S89–95.
   PubMedGoogle Scholar
• Bish LT, Sleeper MM, Brainard B, et al. Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 achieves global cardiac gene transfer in canines. Mol Ther 2008;16:1953–9.
   PubMed Web of Science ®Google Scholar
• Yla-Herttuala S. Gene therapy for heart failure: back to the bench. Mol Ther 2015;23:1551–2.
   PubMed Web of Science ®Google Scholar
• Ishikawa K, Aguero J, Naim C, et al. Percutaneous approaches for efficient cardiac gene delivery. J Cardiovasc Transl Res 2013;6:649–59.
   PubMed Web of Science ®Google Scholar
• Lee SJ, Son S, Yhee JY, et al. Structural modification of siRNA for efficient gene silencing. Biotechnol Adv 2013;31:491–503.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Zhang C, Liang W. Development of RNAi technology for targeted therapy–a track of siRNA based agents to RNAi therapeutics. J Control Rel 2014;193:270–81.
   PubMed Web of Science ®Google Scholar
• Cevc G, Richardsen H. Lipid vesicles and membrane fusion. Adv Drug Deliv Rev 1999;38:207–32.
   PubMed Web of Science ®Google Scholar
• Giacca M, Zacchigna S. Harnessing the microRNA pathway for cardiac regeneration. J Mol Cell Cardiol 2015;89:68–74.
   PubMed Web of Science ®Google Scholar
• Christian DA, Cai S, Bowen DM, et al. Polymersome carriers: from self-assembly to siRNA and protein therapeutics. Eur J Pharmaceut Biopharmaceut 2009;71:463–74.
   PubMed Web of Science ®Google Scholar
• Boussif O, Lezoualc'h F, Zanta MA, et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci U S A 1995;92:7297–301.
   PubMed Web of Science ®Google Scholar
• Zintchenko A, Philipp A, Dehshahri A, Wagner E. Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity. Bioconjugate Hem 2008;19:1448–55.
   PubMed Web of Science ®Google Scholar
• Wagner E. Effects of membrane-active agents in gene delivery. J Control Rel 1998;53:155–8.
   PubMed Web of Science ®Google Scholar
• Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 2003;55:329–47.
   PubMed Web of Science ®Google Scholar
• Islam MA, Park TE, Singh B, et al. Major degradable polycations as carriers for DNA and siRNA. J Control Rel 2014;193:74–89.
   PubMed Web of Science ®Google Scholar
• Lu H, Wang J, Song Z, et al. Recent advances in amino acid N-carboxyanhydrides and synthetic polypeptides: chemistry, self-assembly and biological applications. Chem Commun 2014;50:139–55.
   PubMed Web of Science ®Google Scholar
• Ragelle H, Riva R, Vandermeulen G, et al. Chitosan nanoparticles for siRNA delivery: optimizing formulation to increase stability and efficiency. J Control Rel 2014;176:54–63.
   PubMed Web of Science ®Google Scholar
• Roh YH, Lee JB, Kiatwuthinon P, et al. DNAsomes: multifunctional DNA-based nanocarriers. Small 2011;7:74–8.
   PubMed Web of Science ®Google Scholar
• Tian Y, Liu Y, Wang T, et al. A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice. Sci Transl Med 2015;7:279ra238
   Web of Science ®Google Scholar
• Pasumarthi KB, Field LJ. Cardiomyocyte cell cycle regulation. Circ Res 2002;90:1044–54.
   PubMed Web of Science ®Google Scholar
• Mollova M, Bersell K, Walsh S, et al. Cardiomyocyte proliferation contributes to heart growth in young humans. Proc Natl Acad Sci U S A 2013;110:1446–51.
   PubMed Web of Science ®Google Scholar
• Ahuja P, Sdek P, MacLellan WR. Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol Rev 2007;87:521–44.
   PubMed Web of Science ®Google Scholar
• Li F, Wang X, Capasso JM, Gerdes AM. Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J Mol Cell Cardiol 1996;28:1737–46.
   PubMed Web of Science ®Google Scholar
• Soonpaa MH, Kim KK, Pajak L, et al. Cardiomyocyte DNA synthesis and binucleation during murine development. Am J Physiol 1996;271:H2183–9.
   PubMed Web of Science ®Google Scholar
• Clubb FJ, Jr., Bishop SP. Formation of binucleated myocardial cells in the neonatal rat. An index for growth hypertrophy. Lab Invest 1984;50:571–7.
   PubMed Web of Science ®Google Scholar
• Li JM, Poolman RA, Brooks G. Role of G1 phase cyclins and cyclin-dependent kinases during cardiomyocyte hypertrophic growth in rats. Am J Physiol 1998;275:H814–22.
   PubMed Web of Science ®Google Scholar
• Pines J. Cyclins, CDKs and cancer. Semin Cancer Biol 1995;6:63–72.
   PubMed Web of Science ®Google Scholar
• Brooks G, Poolman RA, McGill CJ, Li JM. Expression and activities of cyclins and cyclin-dependent kinases in developing rat ventricular myocytes. J Mol Cell Cardiol 1997;29:2261–71.
   PubMed Web of Science ®Google Scholar
• Kang MJ, Kim JS, Chae SW, et al. Cyclins and cyclin dependent kinases during cardiac development. Mol Cells 1997;7:360–6.
   PubMed Web of Science ®Google Scholar
• Koh KN, Kang MJ, Frith-Terhune A, et al. Persistent and heterogenous expression of the cyclin-dependent kinase inhibitor, p27KIP1, in rat hearts during development. J Mol Cell Cardiol 1998;30:463–74.
   PubMed Web of Science ®Google Scholar
• Poolman RA, Gilchrist R, Brooks G. Cell cycle profiles and expressions of p21CIP1 AND P27KIP1 during myocyte development. Int J Cardiol 1998;67:133–42.
   PubMed Web of Science ®Google Scholar
• Vara D, Bicknell KA, Coxon CH, Brooks G. Inhibition of E2F abrogates the development of cardiac myocyte hypertrophy. J Biol Chem 2003;278:21388–94.
   PubMed Web of Science ®Google Scholar
• Mahmoud AI, Kocabas F, Muralidhar SA, et al. Meis1 regulates postnatal cardiomyocyte cell cycle arrest. Nature 2013;497:249–53.
   PubMed Web of Science ®Google Scholar
• Campa VM, Gutierrez-Lanza R, Cerignoli F, et al. Notch activates cell cycle reentry and progression in quiescent cardiomyocytes. J Cell Biol 2008;183:129–41.
   PubMed Web of Science ®Google Scholar
• Toyoda M, Shirato H, Nakajima K, et al. Jumonji downregulates cardiac cell proliferation by repressing cyclin D1 expression. Dev Cell 2003;5:85–97.
   PubMed Web of Science ®Google Scholar
• Jung J, Kim TG, Lyons GE, et al. Jumonji regulates cardiomyocyte proliferation via interaction with retinoblastoma protein. J Biol Chem 2005;280:30916–23.
   PubMed Web of Science ®Google Scholar
• Kirshenbaum LA, Abdellatif M, Chakraborty S, Schneider MD. Human E2F-1 reactivates cell cycle progression in ventricular myocytes and represses cardiac gene transcription. Dev Biol 1996;179:402–11.
   PubMed Web of Science ®Google Scholar
• Agah R, Kirshenbaum LA, Abdellatif M, et al. Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo. J Clin Invest 1997;100:2722–8.
   PubMed Web of Science ®Google Scholar
• van Amerongen MJ, Diehl F, Novoyatleva T, et al. E2F4 is required for cardiomyocyte proliferation. Cardiovasc Res 2010;86:92–102.
   PubMed Web of Science ®Google Scholar
• Soonpaa MH, Koh GY, Pajak L, et al. Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice. J Clin Invest 1997;99:2644–54.
   PubMed Web of Science ®Google Scholar
• Tamamori-Adachi M, Ito H, Sumrejkanchanakij P, et al. Critical role of cyclin D1 nuclear import in cardiomyocyte proliferation. Circ Res 2003;92:e12–9.
   PubMed Web of Science ®Google Scholar
• Busk PK, Hinrichsen R, Bartkova J, et al. Cyclin D2 induces proliferation of cardiac myocytes and represses hypertrophy. Exp Cell Res 2005;304:149–61.
   PubMed Web of Science ®Google Scholar
• van Amerongen M, Engel F. Induction of cardiomyocyte proliferation. In: Scientific W, ed. Heart Regeneration. Stem cells and Beyond, FB: Engels, 2012:105–34
   Google Scholar
• Bicknell KA, Coxon CH, Brooks G. Can the cardiomyocyte cell cycle be reprogrammed? J Mol Cell Cardiol 2007;42:706–21.
   PubMed Web of Science ®Google Scholar
• Di Stefano V, Giacca M, Capogrossi MC, et al. Knockdown of cyclin-dependent kinase inhibitors induces cardiomyocyte re-entry in the cell cycle. J Biol Chem 2011;286:8644–54.
   PubMed Web of Science ®Google Scholar
• Chaudhry HW, Dashoush NH, Tang H, et al. Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium. J Biol Chem 2004;279:35858–66.
   PubMed Web of Science ®Google Scholar
• Woo YJ, Panlilio CM, Cheng RK, et al. Therapeutic delivery of cyclin A2 induces myocardial regeneration and enhances cardiac function in ischemic heart failure. Circulation 2006;114:I206–13.
   PubMed Web of Science ®Google Scholar
• Liao HS, Kang PM, Nagashima H, et al. Cardiac-specific overexpression of cyclin-dependent kinase 2 increases smaller mononuclear cardiomyocytes. Circ Res 2001;88:443–50.
   PubMed Web of Science ®Google Scholar
• Pasumarthi KB, Nakajima H, Nakajima HO, et al. Targeted expression of cyclin D2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice. Circ Res 2005;96:110–18.
   PubMed Web of Science ®Google Scholar
• Hassink RJ, Pasumarthi KB, Nakajima H, et al. Cardiomyocyte cell cycle activation improves cardiac function after myocardial infarction. Cardiovasc Res 2008;78:18–25.
   PubMed Web of Science ®Google Scholar
• Ebelt H, Hufnagel N, Neuhaus P, et al. Divergent siblings: E2F2 and E2F4 but not E2F1 and E2F3 induce DNA synthesis in cardiomyocytes without activation of apoptosis. Circ Res 2005;96:509–17.
   PubMed Web of Science ®Google Scholar
• Risebro CA, Smart N, Dupays L, et al. Hand1 regulates cardiomyocyte proliferation versus differentiation in the developing heart. Development 2006;133:4595–606.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Li S, Yuan L, et al. Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms. Genes Dev 2010;24:1746–57.
   PubMed Web of Science ®Google Scholar
• Chakraborty S, Yutzey KE. Tbx20 regulation of cardiac cell proliferation and lineage specialization during embryonic and fetal development in vivo. Dev Biol 2012;363:234–46.
   PubMed Web of Science ®Google Scholar
• Chakraborty S, Sengupta A, Yutzey KE. Tbx20 promotes cardiomyocyte proliferation and persistence of fetal characteristics in adult mouse hearts. J Mol Cell Cardiol 2013;62:203–13.
   PubMed Web of Science ®Google Scholar
• Penton AL, Leonard LD, Spinner NB. Notch signaling in human development and disease. Semin Cell Dev Biol 2012;23:450–7.
   PubMed Web of Science ®Google Scholar
• de la Pompa JL, Epstein JA. Coordinating tissue interactions: notch signaling in cardiac development and disease. Dev Cell 2012;22:244–54.
   PubMed Web of Science ®Google Scholar
• De Strooper B, Annaert W, Cupers P, et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of notch intracellular domain. Nature 1999;398:518–22.
   PubMed Web of Science ®Google Scholar
• Croquelois A, Domenighetti AA, Nemir M, et al. Control of the adaptive response of the heart to stress via the notch1 receptor pathway. J Exp Med 2008;205:3173–85.
   PubMed Web of Science ®Google Scholar
• Gude NA, Emmanuel G, Wu W, et al. Activation of notch-mediated protective signaling in the myocardium. Circ Res 2008;102:1025–35.
   PubMed Web of Science ®Google Scholar
• Kratsios P, Catela C, Salimova E, et al. Distinct roles for cell-autonomous notch signaling in cardiomyocytes of the embryonic and adult heart. Circ Res 2010;106:559–72.
   PubMed Web of Science ®Google Scholar
• Felician G, Collesi C, Lusic M, et al. Epigenetic modification at notch responsive promoters blunts efficacy of inducing notch pathway reactivation after myocardial infarction. Circ Res 2014;115:636–49.
   PubMed Web of Science ®Google Scholar
• Xin M, Kim Y, Sutherland LB, et al. Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Sci Signal 2011;4:ra70
   PubMed Web of Science ®Google Scholar
• von Gise A, Lin Z, Schlegelmilch K, et al. YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A 2012;109:2394–9.
   PubMed Web of Science ®Google Scholar
• Del Re DP, Yang Y, Nakano N, et al. Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. J Biol Chem 2013;288:3977–88.
   PubMed Web of Science ®Google Scholar
• Xin M, Kim Y, Sutherland LB, et al. Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A 2013;110:13839–44.
   PubMed Web of Science ®Google Scholar
• Saucedo LJ, Edgar BA. Filling out the hippo pathway. Nat Rev Mol Cell Biol 2007;8:613–21.
   PubMed Web of Science ®Google Scholar
• Pan D. The hippo signaling pathway in development and cancer. Dev Cell 2010;19:491–505.
   PubMed Web of Science ®Google Scholar
• Heallen T, Zhang M, Wang J, et al. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science 2011;332:458–61.
   PubMed Web of Science ®Google Scholar
• Yamamoto S, Yang G, Zablocki D, et al. Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J Clin Invest 2003;111:1463–74.
   PubMed Web of Science ®Google Scholar
• Matsui YY, Nakano NN, Shao DD, et al. Lats2 is a negative regulator of myocyte size in the heart. Circ Res 2008;103:1309–18.
   PubMed Web of Science ®Google Scholar
• Heallen T, Morikawa Y, Leach J, et al. Hippo signaling impedes adult heart regeneration. Development 2013;140:4683–90.
   PubMed Web of Science ®Google Scholar
• Huang Y, Harrison MR, Osorio A, et al. Igf Signaling is required for cardiomyocyte proliferation during zebrafish heart development and regeneration. PLoS One 2013;8:e67266
   PubMed Web of Science ®Google Scholar
• Engels MC, Rajarajan K, Feistritzer R, et al. Insulin-like growth factor promotes cardiac lineage induction in vitro by selective expansion of early mesoderm. Stem Cells 2014;32:1493–502.
   PubMed Web of Science ®Google Scholar
• Simoes FC, Peterkin T, Patient R. Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators. Development 2011;138:3235–45.
   PubMed Web of Science ®Google Scholar
• Lepilina A, Coon AN, Kikuchi K, et al. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Cell 2006;127:607–19.
   PubMed Web of Science ®Google Scholar
• Bersell K, Arab S, Haring B, Kuhn B. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell 2009;138:257–70.
   PubMed Web of Science ®Google Scholar
• D'Uva G, Aharonov A, Lauriola M, et al. ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation. Nat Cell Biol 2015;17:627–38.
   PubMed Web of Science ®Google Scholar
• Kuhn B, del Monte F, Hajjar RJ, et al. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nat Med 2007;13:962–9.
   PubMed Web of Science ®Google Scholar
• Bock-Marquette I, Saxena A, White MD, et al. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 2004;432:466–72.
   PubMed Web of Science ®Google Scholar
• Engel FB, Schebesta M, Duong MT, et al. p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev 2005;19:1175–87.
   PubMed Web of Science ®Google Scholar
• Beigi F, Schmeckpeper J, Pow-Anpongkul P, et al. C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway. Circ Res 2013;113:372–80.
   PubMed Web of Science ®Google Scholar
• Lorts A, Schwanekamp JA, Elrod JW, et al. Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair. Circ Res 2009;104:e1–7.
   PubMed Web of Science ®Google Scholar
• Gude N, Muraski J, Rubio M, et al. Akt promotes increased cardiomyocyte cycling and expansion of the cardiac progenitor cell population. Circ Res 2006;99:381–8.
   PubMed Web of Science ®Google Scholar
• Matsui T, Li L, Wu JC, et al. Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem 2002;277:22896–901.
   PubMed Web of Science ®Google Scholar
• Ozhan G, Weidinger G. Wnt/β-Catenin signaling in heart regeneration. Cell Regen (Lond) 2015;4:3
   PubMedGoogle Scholar
• Hahn JY, Cho HJ, Bae JW, et al. Beta-catenin overexpression reduces myocardial infarct size through differential effects on cardiomyocytes and cardiac fibroblasts. J Biol Chem 2006;281:30979–89.
   PubMed Web of Science ®Google Scholar
• Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Develop Biol 2004;20:781–810.
   PubMed Web of Science ®Google Scholar
• Hayward P, Kalmar T, Arias AM. Wnt/Notch signalling and information processing during development. Development 2008;135:411–24.
   PubMed Web of Science ®Google Scholar
• Rash JE, Shay JW, Biesele JJ. Cilia in cardiac differentiation. J Ultrastruct Res 1969;29:470–84.
   PubMedGoogle Scholar
• Shenje LT, Andersen P, Halushka MK, et al. Mutations in Alstrom protein impair terminal differentiation of cardiomyocytes. Nature Commun 2014;5:3416
   PubMed Web of Science ®Google Scholar
• Porrello ER, Johnson BA, Aurora AB, et al. MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes. Circ Res 2011;109:670–9.
   PubMed Web of Science ®Google Scholar
• Cao X, Wang J, Wang Z, et al. MicroRNA profiling during rat ventricular maturation: A role for miR-29a in regulating cardiomyocyte cell cycle re-entry. FEBS Lett 2013;587:1548–55.
   PubMed Web of Science ®Google Scholar
• Porrello ER, Mahmoud AI, Simpson E, et al. Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family. Proc Natl Acad Sci U S A 2013;110:187–92.
   PubMed Web of Science ®Google Scholar
• Hullinger TG, Montgomery RL, Seto AG, et al. Inhibition of miR-15 protects against cardiac ischemic injury. Circ Res 2012;110:71–81.
   PubMed Web of Science ®Google Scholar
• Roush S, Slack FJ. The let-7 family of microRNAs. Trends Cell Biol 2008;18:505–16.
   PubMed Web of Science ®Google Scholar
• Coppola A, Romito A, Borel C, et al. Cardiomyogenesis is controlled by the miR-99a/let-7c cluster and epigenetic modifications. Stem Cell Res 2014;12:323–37.
   PubMed Web of Science ®Google Scholar
• Aguirre A, Montserrat N, Zacchigna S, et al. In Vivo activation of a conserved microRNA program induces mammalian heart regeneration. Cell Stem Cell 2014;15:589–604.
   PubMed Web of Science ®Google Scholar
• Eulalio A, Mano M, Dal Ferro M, et al. Functional screening identifies miRNAs inducing cardiac regeneration. Nature 2012;492:376–81.
   PubMed Web of Science ®Google Scholar
• Tiscornia G, Izpisua Belmonte JC. MicroRNAs in embryonic stem cell function and fate. Genes Dev 2010;24:2732–41.
   PubMed Web of Science ®Google Scholar
• Barroso-del Jesus A, Lucena-Aguilar G, Menendez P. The miR-302-367 cluster as a potential stemness regulator in ESCs. Cell Cycle 2009;8:394–8.
   PubMed Web of Science ®Google Scholar
• Chen J, Huang ZP, Seok HY, et al. mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. Circ Res 2013;112:1557–66.
   PubMed Web of Science ®Google Scholar
• Judson RL, Babiarz JE, Venere M, Blelloch R. Embryonic stem cell-specific microRNAs promote induced pluripotency. Nat Biotechnol 2009;27:459–61.
   PubMed Web of Science ®Google Scholar
• Li Z, Yang CS, Nakashima K, Rana TM. Small RNA-mediated regulation of iPS cell generation. Embo J 2011;30:823–34.
   PubMed Web of Science ®Google Scholar
• Bicknell KA, Coxon CH, Brooks G. Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes. Biochem J 2004;382:411–16.
   PubMed Web of Science ®Google Scholar
• Williams SD, Zhu H, Zhang L, Bernstein HS. Adenoviral delivery of human CDC5 promotes G2/M progression and cell division in neonatal ventricular cardiomyocytes. Gene Ther 2006;13:837–43.
   PubMed Web of Science ®Google Scholar
• Shiraishi I, Melendez J, Ahn Y, et al. Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ Res 2004;94:884–91.
   PubMed Web of Science ®Google Scholar
• Muraski JA, Rota M, Misao Y, et al. Pim-1 regulates cardiomyocyte survival downstream of Akt. Nat Med 2007;13:1467–75.
   PubMed Web of Science ®Google Scholar
• Novoyatleva T, Diehl F, van Amerongen MJ, et al. TWEAK is a positive regulator of cardiomyocyte proliferation. Cardiovasc Res 2010;85:681–90.
   PubMed Web of Science ®Google Scholar
• Lin Z, von Gise A, Zhou P, et al. Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circ Res 2014;115:354–63.
   PubMed Web of Science ®Google Scholar
• Morissette MR, Cook SA, Foo S, et al. Myostatin regulates cardiomyocyte growth through modulation of Akt signaling. Circ Res 2006;99:15–24.
   PubMed Web of Science ®Google Scholar