Point-of-care testing (POCT) and evidence-based laboratory medicine (EBLM) – does it leverage any advantage in clinical decision making?

References

• Price CP. Evidence-based laboratory medicine: supporting decision-making. Clin Chem. 2000;46(8 Pt 1):1041–50.
   PubMed Web of Science ®Google Scholar
• Hawkins RC. Laboratory turnaround time. Clin Biochem Rev. 2007;28:179–194.
   PubMedGoogle Scholar
• ISO 22870. 2016. Available from: https://www.iso.org/standard/71119.html
   Google Scholar
• Lundberg GD. Acting on significant laboratory results. JAMA. 1981;245:1762–1763.
   PubMed Web of Science ®Google Scholar
• Plebani M, Favaloro EJ, Lippi G. Patient safety and quality in laboratory and hemostasis testing: a renewed loop? Semin Thromb Hemost. 2012;38:553–558.
   PubMed Web of Science ®Google Scholar
• Lundberg GD. Adding outcome as the 10th step in the brain-to-brain laboratory test loop. Am J Clin Pathol. 2014;141:767–769.
   PubMed Web of Science ®Google Scholar
• Tsai WW, Nash DB, Seamonds B, et al. Point-of-care versus central laboratory testing: an economic analysis in an academic medical center. Clin Therapeut. 1994;16:898–910. discussion 854.
   PubMed Web of Science ®Google Scholar
• Wu AH, Apple FS, Gibler WB, et al. National Academy of Clinical Biochemistry Standards of Laboratory Practice: recommendations for the use of cardiac markers in coronary artery diseases. Clin Chem. 1999;45:1104–1121.
   PubMed Web of Science ®Google Scholar
• Price CP. Point-of-care testing. Impact on medical outcomes. Clin Lab Med. 2001;21:285–303.
   PubMed Web of Science ®Google Scholar
• O'Kane M. Point of care testing – current and emerging perspectives. Point of Care 2014;31:1–5.
   Google Scholar
• Price CP. Point of care testing. BMJ. 2001;322:1285–1288.
   PubMed Web of Science ®Google Scholar
• Cochrane Library. Systematic Reviews August; 2017. Available from: http://www.cochrane.org/search/site/systematic%20reviews
   Google Scholar
• Price CP, Christenson RH. Critical appraisal in the practice of laboratory medicine. Ann Clin Biochem. 2016;53:222–232.
   PubMed Web of Science ®Google Scholar
• Bossuyt PM, Reitsma JB, Bruns DE, et al. STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies. Clin Chem. 2015;61:1446–1452.
   PubMed Web of Science ®Google Scholar
• Heneghan CJ, Garcia-Alamino JM, Spencer EA, et al. Self-monitoring and self-management of oral anticoagulation. Cochrane Database Syst Rev. 2016;7:CD003839.
   PubMedGoogle Scholar
• Sharma P, Scotland G, Cruickshank M, et al. The clinical effectiveness and cost-effectiveness of point-of-care tests (CoaguChek system, INRatio2 PT/INR monitor and ProTime Microcoagulation system) for the self-monitoring of the coagulation status of people receiving long-term vitamin K antagonist therapy, compared with standard UK practice: systematic review and economic evaluation. Health Technol Assess. 2015;19:1–172.
   Web of Science ®Google Scholar
• Aabenhus R, Jensen JU, Jorgensen KJ, et al. Biomarkers as point-of-care tests to guide prescription of antibiotics in patients with acute respiratory infections in primary care. Cochrane Database Syst Rev. 2014;(11):CD010130.
   PubMed Web of Science ®Google Scholar
• McTaggart MP, Newall RG, Hirst JA, et al. Diagnostic accuracy of point-of-care tests for detecting albuminuria: a systematic review and meta-analysis. Ann Intern Med. 2014;160:550–557.
   PubMed Web of Science ®Google Scholar
• Shivkumar S, Peeling R, Jafari Y, et al. Accuracy of rapid and point-of-care screening tests for hepatitis C: a systematic review and meta-analysis. Ann Intern Med. 2012;157:558–566.
   PubMed Web of Science ®Google Scholar
• Al-Ansary L, Farmer A, Hirst J, et al. Point-of-care testing for Hb A1c in the management of diabetes: a systematic review and metaanalysis. Clin Chem. 2011;57:568–576.
   PubMed Web of Science ®Google Scholar
• Gialamas A, St John A, Laurence CO, et al. Point-of-care testing for patients with diabetes, hyperlipidaemia or coagulation disorders in the general practice setting: a systematic review. Fam Pract. 2010;27:17–24.
   PubMed Web of Science ®Google Scholar
• Search MF. [cited 2017 Aug 15]. Available from: http://plus.mcmaster.ca/MacPLUSFS/Default.aspx?Page=1
   Google Scholar
• Christenson RH, Snyder SR, Shaw CS, et al. Laboratory medicine best practices: systematic evidence review and evaluation methods for quality improvement. Clin Chem. 2011;57:816–825.
   PubMed Web of Science ®Google Scholar
• Blattner K, Nixon G, Dovey S, et al. Changes in clinical practice and patient disposition following the introduction of point-of-care testing in a rural hospital. Health Policy (Amsterdam, Netherlands). 2010;96:7–12.
   PubMed Web of Science ®Google Scholar
• Tideman PA, Tirimacco R, Senior DP, et al. Impact of a regionalised clinical cardiac support network on mortality among rural patients with myocardial infarction. Med J Aust. 2014;200:157–160.
   PubMed Web of Science ®Google Scholar
• QAAMS. [cited 2017 Aug 15]. Available from: https://www.qaams.org.au/
   Google Scholar
• Shephard MD, Mazzachi BC, Shephard AK, et al. The impact of point of care testing on diabetes services along Victoria’s Mallee Track: results of a community-based diabetes risk assessment and management program. Rural Remote Health. 2005;5:371.
   PubMedGoogle Scholar
• Shephard MD. Cultural and clinical effectiveness of the 'QAAMS' point-of-care testing model for diabetes management in Australian aboriginal medical services. Clin Biochem Rev. 2006;27:161–170.
   PubMedGoogle Scholar
• Shephard MDMB, Shephard AK, Burgoyne T, et al. Point-of-care testing in Aboriginal hands – a model for chronic disease prevention and management in Indigenous Australia. Point Care. 2006;5:168–176.
   Google Scholar
• Ho C, Cimon K, Weeks L, et al. CADTH Optimal Use Reports. Point-of-Care Troponin Testing in Patients With Symptoms Suggestive of Acute Coronary Syndrome: A Health Technology Assessment. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health Copyright (c) CADTH 2016; 2016.
   Google Scholar
• Hardy V, Thompson M, Alto W, et al. Exploring the barriers and facilitators to use of point of care tests in family medicine clinics in the United States. BMC Fam Pract. 2016;17:149.
   PubMed Web of Science ®Google Scholar
• Huddy JR, Ni MZ, Barlow J, et al. Point-of-care C reactive protein for the diagnosis of lower respiratory tract infection in NHS primary care: a qualitative study of barriers and facilitators to adoption. BMJ Open. 2016;6:e009959.
   PubMed Web of Science ®Google Scholar
• Davids M, Dheda K, Pant Pai N, et al. A survey on use of rapid tests and tuberculosis diagnostic practices by primary health care providers in south africa: implications for the development of new point-of-care tests. PLoS One. 2015;10:e0141453.
   PubMed Web of Science ®Google Scholar
• St John A, Tirimacco R, Badrick T, et al. Internet support for point-of-care testing in primary care. Aust Fam Physician. 2015;44:10–11.
   PubMed Web of Science ®Google Scholar
• Hobbs FD, Delaney BC, Fitzmaurice DA, et al. A review of near patient testing in primary care. Health Technol Assess (Winchester, England) 1997;1:i–iv, 1–229.
   Google Scholar
• Laurence C, Gialamas A, Yelland L, et al. A pragmatic cluster randomised controlled trial to evaluate the safety, clinical effectiveness, cost effectiveness and satisfaction with point of care testing in a general practice setting – rationale, design and baseline characteristics. Trials. 2008;9:50.
   PubMed Web of Science ®Google Scholar
• Scott IA. Non-inferiority trials: determining whether alternative treatments are good enough. Med J Aust. 2009;190:326–330.
   PubMed Web of Science ®Google Scholar
• Laurence CO, Moss JR, Briggs NE, et al. The cost-effectiveness of point of care testing in a general practice setting: results from a randomised controlled trial. BMC Health Serv Res. 2010;10:165.
   PubMed Web of Science ®Google Scholar
• Health Quality Ontario. Point-of-Care International Normalized Ratio (INR) monitoring devices for patients on long-term oral anticoagulation therapy: an evidence-based analysis. Ont Health Technol Assess Ser. 2009;9:1–114.
   Google Scholar
• Kristoffersen AH, Thue G, Ajzner E, et al. Interpretation and management of INR results: a case history based survey in 13 countries. Thromb Res. 2012;130:309–315.
   PubMed Web of Science ®Google Scholar
• Mallen CD, Nicholl BI. The effects of implementing a point-of-care electronic template to prompt routine anxiety and depression screening in patients consulting for osteoarthritis (the primary care osteoarthritis trial): a cluster randomised trial in primary care. PLoS Med. 2017;14:e1002273.
   PubMed Web of Science ®Google Scholar
• Wells S, Rafter N, Kenealy T, et al. The impact of a point-of-care testing device on CVD risk assessment completion in New Zealand primary-care practice: A cluster randomised controlled trial and qualitative investigation. PLoS One. 2017;12:e0174504.
   PubMed Web of Science ®Google Scholar
• McDonell MG, Graves MC, West II, et al. Utility of point-of-care urine drug tests in the treatment of primary care patients with drug use disorders. J Addict Med. 2016;10:196–201.
   PubMed Web of Science ®Google Scholar
• Verbakel JY, Lemiengre MB, De Burghgraeve T, et al. Should all acutely ill children in primary care be tested with point-of-care CRP: a cluster randomised trial. BMC Med. 2016;14:131.
   PubMed Web of Science ®Google Scholar
• Heneghan C, Ward A, Perera R, et al. Self-monitoring of oral anticoagulation: systematic review and meta-analysis of individual patient data. Lancet (London, England). 2012;379:322–334.
   PubMed Web of Science ®Google Scholar
• Kengne AP, June-Rose McHiza Z, Amoah AG, et al. Cardiovascular diseases and diabetes as economic and developmental challenges in Africa. Prog Cardiovasc Dis. 2013;56:302–313.
   PubMed Web of Science ®Google Scholar
• Reynolds TM, Pillay TS. Donald Rumsfeld and point-of-care testing (POCT): the problem of unknown unknowns-venous blood and glucose oxidase-based test strips. J Clin Pathol. 2016;69:839–840.
   PubMed Web of Science ®Google Scholar
• Nathan DM, Genuth S, Lachin J, et al. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977–986.
   PubMed Web of Science ®Google Scholar
• Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet (London, England). 1998;352:837–853.
   PubMed Web of Science ®Google Scholar
• Yoo EH, Lee SY. Glucose biosensors: an overview of use in clinical practice. Sensors (Basel, Switzerland). 2010;10:4558–4576.
   PubMed Web of Science ®Google Scholar
• Tirimacco R, Koumantakis G, Erasmus R, et al. Glucose meters – fit for clinical purpose. Clin Chem Lab Med. 2013;51:943–952.
   PubMed Web of Science ®Google Scholar
• Janssen K, Delanghe J. Importance of the pre-analytical phase in blood glucose analysis. Acta Clin Belg. 2010;65:311–318.
   PubMed Web of Science ®Google Scholar
• Jacobsz M, Dednam M. Pre-analytical, analytical and postanalytical considerations in glucose point-of-care testing. S Afr Med J. 2007;97:805.
   PubMed Web of Science ®Google Scholar
• Farmer AJ, Perera R, Ward A, et al. Meta-analysis of individual patient data in randomised trials of self monitoring of blood glucose in people with non-insulin treated type 2 diabetes. BMJ (Clin Res Ed). 2012;344:e486.
   PubMedGoogle Scholar
• Clar C, Barnard K, Cummins E, et al. Self-monitoring of blood glucose in type 2 diabetes: systematic review. Health Technol Assess. 2010;14:1–140.
   Web of Science ®Google Scholar
• Malanda UL, Welschen LM, Riphagen II, et al. Self-monitoring of blood glucose in patients with type 2 diabetes mellitus who are not using insulin. Cochrane Database Syst Rev. 2012;1:CD005060.
   PubMedGoogle Scholar
• Plummer MP, Bellomo R, Cousins CE, et al. Dysglycaemia in the critically ill and the interaction of chronic and acute glycaemia with mortality. Intensive Care Med 2014;40:973–980.
   PubMed Web of Science ®Google Scholar
• Honiden S, Inzucchi SE. Metabolic management during critical illness: glycemic control in the ICU. Semin Respir Crit Care Med. 2015;36:859–869.
   PubMed Web of Science ®Google Scholar
• Mesotten D, Van den Berghe G. Clinical benefits of tight glycaemic control: focus on the intensive care unit. Best Pract Res Clin Anaesthesiol. 2009;23:421–429.
   PubMedGoogle Scholar
• van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001;345:1359–1367.
   PubMed Web of Science ®Google Scholar
• Van den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006;354:449–461.
   PubMed Web of Science ®Google Scholar
• Brunkhorst FM, Engel C, Bloos F, et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med. 2008;358:125–139.
   PubMed Web of Science ®Google Scholar
• Preiser JC, Devos P, Ruiz-Santana S, et al. A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study. Intensive Care Med. 2009;35:1738–1748.
   PubMed Web of Science ®Google Scholar
• Finfer S, Chittock DR, Su SY, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360:1283–1297.
   PubMed Web of Science ®Google Scholar
• Finfer S, Liu B, Chittock DR, et al. Hypoglycemia and risk of death in critically ill patients. N Engl J Med. 2012;367:1108–1118.
   PubMed Web of Science ®Google Scholar
• Paddle JJ, Eve RL, Sharpe KA. Changing practice with changing research: results of two UK national surveys of intensive insulin therapy in intensive care patients. Anaesthesia. 2011;66:92–96.
   PubMed Web of Science ®Google Scholar
• Kaukonen KM, Bailey M, Pilcher D, et al. Glycaemic control in Australia and New Zealand before and after the NICE-SUGAR trial: a translational study. Crit Care. 2013;17:R215.
   PubMed Web of Science ®Google Scholar
• Strasma PJ, Finfer S, Flower O, et al. Use of an intravascular fluorescent continuous glucose sensor in ICU patients. J Diabetes Sci Technol. 2015;9:762–770.
   PubMedGoogle Scholar
• Rahbar S. An abnormal hemoglobin in red cells of diabetics. Clin Chim Acta. 1968;22:296–298.
   PubMed Web of Science ®Google Scholar
• Diagnosis and classification of diabetes mellitus. Diab Care. 2010;33(Suppl 1):S62–S69.
   PubMed Web of Science ®Google Scholar
• External Experts. Use of Glycated Haemoglobin (HbA1c) in the Diagnosis of Diabetes Mellitus: Abbreviated Report of a WHO Consultation. Geneva: World Health Organisation A, 2011.
   Google Scholar
• Florkowski C, Crooke M. Standardisation of reporting haemoglobin A1c: adoption of the New Zealand Society for the Study of Diabetes (NZSSD) position statement. N Z Med J. 2010;123:43–49.
   PubMedGoogle Scholar
• Schnell O, Crocker JB, Weng J. Impact of HbA1c testing at point of care on diabetes management. J Diabetes Sci Technol. 2017;11:611–617.
   PubMedGoogle Scholar
• Lenters-Westra E, Slingerland RJ. Three of 7 hemoglobin A1c point-of-care instruments do not meet generally accepted analytical performance criteria. Clin Chem. 2014;60:1062–1072.
   PubMed Web of Science ®Google Scholar
• Paknikar S, Sarmah R, Sivaganeshan L, et al. Long-term performance of point-of-care hemoglobin A1c assays. J Diabetes Sci Technol. 2016;10:1308–1315.
   PubMedGoogle Scholar
• Miller CD, Barnes CS, Phillips LS, et al. Rapid A1c availability improves clinical decision-making in an urban primary care clinic. Diabetes Care. 2003;26:1158–1163.
   PubMed Web of Science ®Google Scholar
• American Diabetes Association. Classification and diagnosis of diabetes. Diabetes Care. 2017;40(Suppl 1):S11–S24.
   Google Scholar
• Motta LA, Shephard MDS, Brink J, et al. Point-of-care testing improves diabetes management in a primary care clinic in South Africa. Prim Care Diabetes. 2017;11:248–253.
   PubMed Web of Science ®Google Scholar
• Grieve R, Beech R, Vincent J, et al. Near patient testing in diabetes clinics: appraising the costs and outcomes. Health Technol Assess (Winchester, England). 1999;3:1–74.
   PubMedGoogle Scholar
• Khunti K, Stone MA, Burden AC, et al. Randomised controlled trial of near-patient testing for glycated haemoglobin in people with type 2 diabetes mellitus. Br J Gen Pract. 2006;56:511–517.
   PubMed Web of Science ®Google Scholar
• Bubner TK, Laurence CO, Gialamas A, et al. Effectiveness of point-of-care testing for therapeutic control of chronic conditions: results from the PoCT in General Practice Trial. Med J Aust. 2009;190:624–626.
   PubMed Web of Science ®Google Scholar
• Klepser ME, Adams AJ, Srnis P, et al. U.S. community pharmacies as CLIA-waived facilities: prevalence, dispersion, and impact on patient access to testing. Res Soc Admin Pharm. 2016;12:614–621.
   PubMed Web of Science ®Google Scholar
• Weber NC, Klepser ME, Akers JM, et al. Use of CLIA-waived point-of-care tests for infectious diseases in community pharmacies in the United States. Expert Rev Mol Diagnost. 2016;16:253–264.
   PubMed Web of Science ®Google Scholar
• Haggerty L, Tran D. Cholesterol point-of-care testing for community pharmacies: a review of the current literature. J Pharm Pract. 2017;30:451–458.
   PubMedGoogle Scholar
• Gubbins PO, Klepser ME, Dering-Anderson AM, et al. Point-of-care testing for infectious diseases: opportunities, barriers, and considerations in community pharmacy. J Am Pharm Assoc. 2014;54:163–171.
   Google Scholar
• Bacci JL, Klepser D, Tilley H, et al. Community pharmacy-based point-of-care testing: a case study of pharmacist-physician collaborative working relationships. Res Soc Admin Pharm. 2017.DOI: 10.1016/j.sapharm.2016.12.005
   Google Scholar
• St John A. The evidence to support point-of-care testing. Clin Biochem Rev. 2010;31:111–119.
   PubMedGoogle Scholar
• Challen L, Agbahiwe S, Cantieri T, et al. Impact of point-of-care implementation in pharmacist-run anticoagulation clinics within a community-owned health system: a two-year retrospective analysis. Hospital Pharm. 2015;50:783–788.
   PubMedGoogle Scholar
• Morrissey H, Ball P, Jackson D, et al. Use of chronic disease management algorithms in Australian community pharmacies. Res Soc Admin Pharm. 2015;11:176–196.
   PubMed Web of Science ®Google Scholar
• Hohmeier KC, McDonough SLK, Wang J. Co-creation of market expansion in point-of-care testing in the United States: Industry leadership perspectives on the community pharmacy segment. Res Soc Admin Pharm. 2017;13:746–753.
   PubMed Web of Science ®Google Scholar
• IATDMCT. [cited 2017 Aug 15]. Available from: https://www.iatdmct.org/about-us.html
   Google Scholar
• Sanavio B, Krol S. On the slow diffusion of point-of-care systems in therapeutic drug monitoring. Front Bioeng Biotechnol. 2015;3:20.
   PubMed Web of Science ®Google Scholar
• Afonso J, Lopes S, Goncalves R, et al. Proactive therapeutic drug monitoring of infliximab: a comparative study of a new point-of-care quantitative test with two established ELISA assays. Aliment Pharmacol Ther. 2016;44:684–692.
   PubMed Web of Science ®Google Scholar
• Schiller MJ, Shumway M, Batki SL. Utility of routine drug screening in a psychiatric emergency setting. Psychiatr Serv (Washington, DC). 2000;51:474–478.
   PubMed Web of Science ®Google Scholar
• Tenenbein M. Do you really need that emergency drug screen? Clin Toxicol (Phila). 2009;47:286–291.
   PubMed Web of Science ®Google Scholar
• Calo PG, Pisano G, Loi G, et al. Intraoperative parathyroid hormone assay during focused parathyroidectomy: the importance of 20 minutes measurement. BMC Surg. 2013;13:36.
   PubMed Web of Science ®Google Scholar
• Affleck A, Parks P, Drummond A, et al. Emergency department overcrowding and access block. CJEM. 2013;15:359–384.
   PubMedGoogle Scholar
• Bukhari H, Albazli K, Almaslmani S, et al. Analysis of waiting time in emergency department of Al-Noor Specialist Hospital, Makkah, Saudi Arabia. Open J Emerg Med. 2014;2:7.
   Google Scholar
• Crawford K, Morphet J, Jones T, et al. Initiatives to reduce overcrowding and access block in Australian emergency departments: a literature review. Collegian. 2014;21:359–366.
   PubMed Web of Science ®Google Scholar
• Kendall J, Reeves B, Clancy M. Point of care testing: randomised controlled trial of clinical outcome. BMJ (Clin Res Ed). 1998;316:1052–1057.
   PubMed Web of Science ®Google Scholar
• Lewandrowski KFJ, Tochka L, Lee-Lewandrowski E. Implementation of a point-of-care satellite laboratory (kiosk) in the emergency department of an academic medical center: an 8-year experience at the Massachusetts General Hospital. Point of Care. 2011;10:93–97.
   Google Scholar
• Soremekun OA, Datner EM, Banh S, et al. Utility of point-of-care testing in ED triage. Am J Emerg Med. 2013;31:291–296.
   PubMed Web of Science ®Google Scholar
• Singer AJ, Williams J, Taylor M, et al. Comprehensive bedside point of care testing in critical ED patients: a before and after study. Am J Emerg Med. 2015;33:776–780.
   PubMed Web of Science ®Google Scholar
• Asha SE, Chan AC, Walter E, et al. Impact from point-of-care devices on emergency department patient processing times compared with central laboratory testing of blood samples: a randomised controlled trial and cost-effectiveness analysis. Emerg Med J. 2014;31:714–719.
   PubMed Web of Science ®Google Scholar
• Kankaanpaa M, Raitakari M, Muukkonen L, et al. Use of point-of-care testing and early assessment model reduces length of stay for ambulatory patients in an emergency department. Scand J Trauma Resusc Emerg Med. 2016;24:125.
   PubMed Web of Science ®Google Scholar
• Ryan RJ, Lindsell CJ, Hollander JE, et al. A multicenter randomized controlled trial comparing central laboratory and point-of-care cardiac marker testing strategies: the Disposition Impacted by Serial Point of Care Markers in Acute Coronary Syndromes (DISPO-ACS) trial. Ann Emerg Med. 2009;53:321–328.
   PubMed Web of Science ®Google Scholar
• Johnson MMLK. Analysis of emergency department test ordering patterns in an urban academic medical center: can. the point-of-care option in a satellite laboratory provide sufficient menu to permit full service testing? Point of Care. 2007;6:134–138.
   Google Scholar
• Fitzgerald P, Goodacre SW, Cross E, et al. Cost-effectiveness of point-of-care biomarker assessment for suspected myocardial infarction: the randomized assessment of treatment using panel Assay of cardiac markers (RATPAC) trial. Acad Emerg Med. 2011;18:488–495.
   PubMed Web of Science ®Google Scholar
• Lee EJ, Shin SD, Song KJ, et al. A point-of-care chemistry test for reduction of turnaround and clinical decision time. Am J Emerg Med. 2011;29:489–495.
   PubMed Web of Science ®Google Scholar
• Mockel M, Searle J, Muller R, et al. Chief complaints in medical emergencies: do they relate to underlying disease and outcome? Emergency Medicine Study (CHARITEM). Eur J Emerg Med. 2013;20:103–108.
   PubMed Web of Science ®Google Scholar
• Weiss AJ, Wier LM, Stocks C, Blanchard J. Overview of Emergency Department Visits in the United States, 2011: Statistical Brief #174. Healthcare Cost and Utilization Project (HCUP) Statistical Briefs. Rockville (MD): Agency for Healthcare Research and Quality (US); 2006.
   Google Scholar
• Barrett ML, Smith MW, Elixhauser A, et al. Utilization of Intensive Care Services, 2011: Statistical Brief #185. Healthcare Cost and Utilization Project (HCUP) Statistical Briefs. Rockville (MD): Agency for Healthcare Research and Quality (US); 2006.
   Google Scholar
• GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet (London, England). 2015;385:117–171.
   PubMed Web of Science ®Google Scholar
• Thygesen K, Alpert JS, Jaffe AS, et al. Third universal definition of myocardial infarction. Global Heart. 2012;7:275–295.
   PubMedGoogle Scholar
• Christenson RH, Azzazy HM. Cardiac point of care testing: a focused review of current National Academy of Clinical Biochemistry guidelines and measurement platforms. Clin Biochem. 2009;42:150–157.
   PubMed Web of Science ®Google Scholar
• Apple FS, Collinson PO. Analytical characteristics of high-sensitivity cardiac troponin assays. Clin Chem. 2012;58:54–61.
   PubMed Web of Science ®Google Scholar
• Roffi M, Patrono C, Collet JP, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the. Eur Heart J. 2016;37:267–315.
   PubMed Web of Science ®Google Scholar
• Tan JWC, Lam CSP, Kasim SS, et al. Asia-Pacific consensus statement on the optimal use of high-sensitivity troponin assays in acute coronary syndromes diagnosis: focus on hs-TnI. Heart Asia. 2017;9:81–87.
   PubMedGoogle Scholar
• Apple FS, Sandoval Y, Jaffe AS, et al. Cardiac troponin assays: guide to understanding analytical characteristics and their impact on clinical care. Clin Chem. 2017;63:73–81.
   PubMed Web of Science ®Google Scholar
• Kozinski M, Krintus M, Kubica J, et al. High-sensitivity cardiac troponin assays: From improved analytical performance to enhanced risk stratification. Crit Rev Clin Lab Sci. 2017;54:143–172.
   PubMed Web of Science ®Google Scholar
• Cullen LA, Mills NL. Point: the use of sex-specific cutpoints for high-sensitivity cardiac troponin assays. Clin Chem. 2017;63:261–263.
   PubMed Web of Science ®Google Scholar
• Amundson BE, Apple FS. Cardiac troponin assays: a review of quantitative point-of-care devices and their efficacy in the diagnosis of myocardial infarction. Clin Chem Lab Med. 2015;53:665–676.
   PubMed Web of Science ®Google Scholar
• Slagman A, von Recum J, Mockel M, et al. Diagnostic performance of a high-sensitive troponin T assay and a troponin T point of care assay in the clinical routine of an Emergency Department: a clinical cohort study. Int J Cardiol. 2017;230:454–460.
   PubMed Web of Science ®Google Scholar
• Venge P, van Lippen L, Blaschke S, et al. Equal clinical performance of a novel point-of-care cardiac troponin I (cTnI) assay with a commonly used high-sensitivity cTnI assay. Clin Chim Acta. 2017;469:119–125.
   PubMed Web of Science ®Google Scholar
• Pecoraro V, Germagnoli L, Banfi G. Point-of-care testing: where is the evidence? A systematic survey. Clin Chem Lab Med. 2014;52:313–324.
   PubMed Web of Science ®Google Scholar
• Nichols JH, Christenson RH, Clarke W, et al. Executive summary. The national academy of clinical biochemistry laboratory medicine practice guideline: evidence-based practice for point-of-care testing. Clin Chim Acta. 2007;379:14–28. discussion 9-30.
   PubMed Web of Science ®Google Scholar
• Goodacre SW, Bradburn M, Cross E, et al. The randomised assessment of treatment using panel assay of cardiac markers (RATPAC) trial: a randomised controlled trial of point-of-care cardiac markers in the emergency department. Heart (Br Cardiac Soc). 2011;97:190–196.
   PubMed Web of Science ®Google Scholar
• Tang WH. B-type natriuretic peptide: a critical review. Congest Heart Fail. 2007;13:48–52.
   PubMedGoogle Scholar
• Ponikowski P, Voors AA, Anker SD, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37:2129–2200.
   PubMed Web of Science ®Google Scholar
• Lee-Lewandrowski E, Nichols J, Van Cott E, et al. Implementation of a rapid whole blood D-dimer test in the emergency department of an urban academic medical center: impact on ED length of stay and ancillary test utilization. Am J Clin Pathol. 2009;132:326–331.
   PubMed Web of Science ®Google Scholar
• Moe GW, Ezekowitz JA, O'Meara E, et al. The 2014 Canadian cardiovascular society heart failure management guidelines focus update: anemia, biomarkers, and recent therapeutic trial implications. Can J Cardiol. 2015;31:3–16.
   PubMed Web of Science ®Google Scholar
• Hill SA, Booth RA, Santaguida PL, et al. Use of BNP and NT-proBNP for the diagnosis of heart failure in the emergency department: a systematic review of the evidence. Heart Fail Rev. 2014;19:421–438.
   PubMed Web of Science ®Google Scholar
• Clerico A, Passino C, Franzini M, et al. Cardiac biomarker testing in the clinical laboratory: where do we stand? General overview of the methodology with special emphasis on natriuretic peptides. Clin Chim Acta. 2015;443:17–24.
   PubMed Web of Science ®Google Scholar
• Clerico A, Franzini M, Masotti S, et al. State of the art of immunoassay methods for B-type natriuretic peptides: an update. Crit Rev Clin Lab Sci. 2015;52:56–69.
   PubMed Web of Science ®Google Scholar
• Franzini M, Masotti S, Prontera C, et al. Systematic differences between BNP immunoassays: comparison of methods using standard protocols and quality control materials. Clin Chim Acta. 2013;424:287–291.
   PubMed Web of Science ®Google Scholar
• Maisel AS, Daniels LB. Breathing not properly 10 years later: what we have learned and what we still need to learn. J Am Coll Cardiol. 2012;60:277–282.
   PubMed Web of Science ®Google Scholar
• Mueller C, Laule-Kilian K, Schindler C, et al. Cost-effectiveness of B-type natriuretic peptide testing in patients with acute dyspnea. Arch Intern Med. 2006;166:1081–1087.
   PubMedGoogle Scholar
• Konstantinides SV, Torbicki A, Agnelli G, et al. 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism. Eur Heart J. 2014;35:3033–3069. 69a-69k.
   PubMed Web of Science ®Google Scholar
• Marquardt U, Apau D. Point-of-care D-dimer testing in emergency departments. Emerg Nurse. 2015;23:29–35.
   PubMedGoogle Scholar
• Gruson D, Thys F, Ketelslegers JM, et al. Multimarker panel in patients admitted to emergency department: a comparison with reference methods. Clin Biochem. 2009;42:185–188.
   PubMed Web of Science ®Google Scholar
• Singer AJ, Thode HC, Jr., Green GB, et al. The incremental benefit of a shortness-of-breath biomarker panel in emergency department patients with dyspnea. Acad Emerg Med. 2009;16:488–494.
   PubMed Web of Science ®Google Scholar
• Sutton JP, Friedman B. Trends in Septicemia Hospitalizations and Readmissions in Selected HCUP States, 2005 and 2010: Statistical Brief #161. Healthcare Cost and Utilization Project (HCUP) Statistical Briefs. Rockville (MD): Agency for Healthcare Research and Quality (US); 2006.
   Google Scholar
• Rhodes A, Evans LE, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med. 2017;43:304–377.
   PubMed Web of Science ®Google Scholar
• Ismail F, Mackay WG, Kerry A, et al. The accuracy and timeliness of a point of care lactate measurement in patients with Sepsis. Scand J Trauma Resusc Emerg Med. 2015;23:68.
   PubMed Web of Science ®Google Scholar
• Singer AJ, Taylor M, LeBlanc D, et al. ED bedside point-of-care lactate in patients with suspected sepsis is associated with reduced time to iv fluids and mortality. Am J Emerg Med. 2014;32:1120–1124.
   PubMed Web of Science ®Google Scholar
• Goyal M, Pines JM, Drumheller BC, et al. Point-of-care testing at triage decreases time to lactate level in septic patients. J Emerg Med. 2010;38:578–581.
   PubMed Web of Science ®Google Scholar
• Purcarea A, Bourgarit A, Sovaila A, et al. Brief report: Serial capillary lactate measurement predict the evolution of early sepsis. J Med Life. 2016;9:74–78.
   PubMedGoogle Scholar
• Sabat J, Gould S, Gillego E, et al. The use of finger-stick blood to assess lactate in critically ill surgical patients. Ann Med Surg (2012). 2016;10:41–48.
   PubMed Web of Science ®Google Scholar
• Contenti J, Corraze H, Lemoel F, et al. Effectiveness of arterial, venous, and capillary blood lactate as a sepsis triage tool in ED patients. Am J Emerg Med. 2015;33:167–172.
   PubMed Web of Science ®Google Scholar
• Choudhary R, Sitaraman S, Choudhary A. Lactate clearance as the predictor of outcome in pediatric septic shock. J Emerg Trauma Shock. 2017;10:55–59.
   PubMedGoogle Scholar
• Shirley TL. POC lactate: a marker for diagnosis, prognosis, and guiding therapy in the critically ill. Point Care. 2007;6:192–200.
   Google Scholar
• Rossi AF, Khan D. Point of care testing: improving pediatric outcomes. Clin Biochem. 2004;37:456–461.
   PubMed Web of Science ®Google Scholar
• Zeserson E, Goodgame B, Hess JD, et al. Correlation of venous blood gas and pulse oximetry with arterial blood gas in the undifferentiated critically Ill patient. J Intens Care Med. 2016 [Jun 9].DOI: 10.1177/0885066616652597
   PubMedGoogle Scholar
• Dimeski G, Morgan TJ, Presneill JJ, et al. Disagreement between ion selective electrode direct and indirect sodium measurements: estimation of the problem in a tertiary referral hospital. J Crit Care. 2012;27:326.e9–316.
   PubMed Web of Science ®Google Scholar
• King RI, Mackay RJ, Florkowski CM, et al. Electrolytes in sick neonates – which sodium is the right answer? Arch Dis Child Fetal Neonatal Ed. 2013;98:F74–F76.
   PubMed Web of Science ®Google Scholar
• Joosen AM, Boonen K, Hulsman N, et al. Hypernatraemia in disguise. Clin Chem Lab Med. 2014;52:e231–e234.
   PubMed Web of Science ®Google Scholar
• Langelaan ML, Kamp L, Zandijk E, et al. Prevalence of pseudonatremia in a clinical laboratory – role of the water content. Clin Chem Lab Med. 2017;55:546–553.
   PubMed Web of Science ®Google Scholar
• Jose RJ, Preller J. Near-patient testing of potassium levels using arterial blood gas analysers: can we trust these results? Emerg Med J. 2008;25:510–513.
   PubMed Web of Science ®Google Scholar
• Mirzazadeh M, Morovat A, James T, et al. Point-of-care testing of electrolytes and calcium using blood gas analysers: it is time we trusted the results. Emerg Med J. 2016;33:181–186.
   PubMed Web of Science ®Google Scholar
• Wier LM, Yu H, Owens PL, Washington R. Overview of Children in the Emergency Department, 2010: Statistical Brief #157. Healthcare Cost and Utilization Project (HCUP) Statistical Briefs. Rockville (MD): Agency for Healthcare Research and Quality (US); 2006.
   Google Scholar
• Van den Bruel A, Thompson MJ, Haj-Hassan T, et al. Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review. BMJ (Clin Res Ed). 2011;342:d3082.
   PubMed Web of Science ®Google Scholar
• Ivaska L, Niemela J, Leino P, et al. Accuracy and feasibility of point-of-care white blood cell count and C-reactive protein measurements at the pediatric emergency department. PLoS One. 2015;10:e0129920.
   PubMed Web of Science ®Google Scholar
• Nijman RG, Moll HA, Vergouwe Y, et al. C-Reactive protein bedside testing in febrile children lowers length of stay at the emergency department. Pediatr Emerg Care. 2015;31:633–639.
   PubMedGoogle Scholar
• Hernandez-Bou S, Trenchs V, Vanegas MI, et al. Evaluation of the bedside Quikread go(R) CRP test in the management of febrile infants at the emergency department. Eur J Clin Microbiol Infect Dis. 2017;36:1205–1211.
   PubMed Web of Science ®Google Scholar
• Doan Q, Enarson P, Kissoon N, et al. Rapid viral diagnosis for acute febrile respiratory illness in children in the Emergency Department. Cochrane Database Syst Rev. 2014;(9):CD006452.
   Google Scholar
• Hsiao AL, Santucci KA, Dziura J, et al. A randomized trial to assess the efficacy of point-of-care testing in decreasing length of stay in a pediatric emergency department. Pediatr Emerg Care. 2007;23:457–462.
   PubMed Web of Science ®Google Scholar
• Whitney RE, Santucci K, Hsiao A, et al. Cost-effectiveness of point-of-care testing for dehydration in the pediatric ED. Am J Emerg Med. 2016;34:1573–1575.
   PubMed Web of Science ®Google Scholar
• Milner DHK. Is the point-of-care testing program meeting the pediatric emergency department’s needs? Point of Care. 2014;13:31–34.
   Google Scholar
• Niska R, Bhuiya F, Xu J. National Hospital Ambulatory Medical Care Survey: 2007 emergency department summary. Natl Health Stat Rep. 2010;(26):1–31.
   PubMedGoogle Scholar
• Gronowski AM, Cervinski M, Stenman UH, et al. False-negative results in point-of-care qualitative human chorionic gonadotropin (hCG) devices due to excess hCGbeta core fragment. Clin Chem. 2009;55:1389–1394.
   PubMed Web of Science ®Google Scholar
• Greene DN, Schmidt RL, Kamer SM, et al. Limitations in qualitative point of care hCG tests for detecting early pregnancy. Clin Chim Acta. 2013;415:317–321.
   PubMed Web of Science ®Google Scholar
• Nerenz RD, Song H, Gronowski AM. Screening method to evaluate point-of-care human chorionic gonadotropin (hCG) devices for susceptibility to the hook effect by hCG β core fragment: evaluation of 11 devices. Clin Chem. 2014;60:667–674.
   PubMed Web of Science ®Google Scholar
• Gronowski AM, Nerenz RD. Assessing the risk of false negative point-of-care urinary human chorionic gonadotropin device results due to beta core fragment. Clin Biochem. 2015;48:97–98.
   PubMed Web of Science ®Google Scholar
• Nerenz RD, Gronowski AM. Qualitative point-of-care human chorionic gonadotropin testing: can we defuse this ticking time bomb? Clin Chem. 2015;61:483–486.
   PubMed Web of Science ®Google Scholar
• Mausner Geffen E, Slywotzky C, Bennett G. Pitfalls and tips in the diagnosis of ectopic pregnancy. Abdom Radiol (Ny). 2017;42:1524–1542.
   PubMed Web of Science ®Google Scholar
• Plerhoples W, Zwemer FL, Jr, Bazarian J. Point of care pregnancy testing provides staff satisfaction but does not change ED length of stay. Am J Emerg Med. 2004;22:460–464.
   PubMed Web of Science ®Google Scholar
• Lee-Lewandrowski E, Lewandrowski K. Perspectives on cost and outcomes for point-of-care testing. Clin Lab Med. 2009;29:479–489.
   PubMed Web of Science ®Google Scholar
• Scott HF, Donoghue AJ, Gaieski DF, et al. The utility of early lactate testing in undifferentiated pediatric systemic inflammatory response syndrome. Acad Emerg Med. 2012;19:1276–1280.
   PubMed Web of Science ®Google Scholar