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Review Article

Synovial fluid proteomics in the pursuit of arthritis mediators: An evolving field of novel biomarker discovery

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Pages 495-505 | Received 25 Aug 2017, Accepted 20 Nov 2017, Published online: 04 Dec 2017

References

  • Song J, Chang HJ, Tirodkar M, et al. Racial/ethnic differences in activities of daily living disability in older adults with arthritis: a longitudinal study. Arthritis Rheum. 2007;57:1058–1066.
  • Hootman JM, Helmick CG, Brady TJ. A public health approach to addressing arthritis in older adults: the most common cause of disability. Am J Public Health. 2012;102:426–433.
  • Lagacé C, O’Donnell S, McRae L, et al. Life with arthritis in Canada: a personal and public health challenge. Ottawa: Public Health Agency of Canada; 2010:128.
  • Centers for Disease Control and Prevention. Arthritis as a potential barrier to physical activity among adults with diabetes – United States, 2005 and 2007. MMWR Morb Mortal Wkly Rep. 2008;57:486–489.
  • Centers for Disease Control and Prevention. Arthritis as a potential barrier to physical activity among adults with heart disease – United States, 2005 and 2007. MMWR Morb Mortal Wkly Rep. 2009;58:165–169.
  • Sophia Fox AJ, Bedi A, Rodeo SA. The basic science of articular cartilage: structure, composition, and function. Sports Health. 2009;1:461–468.
  • Gibson DS, Rooney ME. The human synovial fluid proteome: a key factor in the pathology of joint disease. Prot Clin Appl. 2007;1:889–899.
  • Hui AY, McCarty WJ, Masuda K, et al. A systems biology approach to synovial joint lubrication in health, injury, and disease. Wires Syst Biol Med. 2012;4:15–37.
  • Goekoop-Ruiterman YP, de Vries-Bouwstra JK, Allaart CF, et al. Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the best study): a randomized, controlled trial. Arthritis Rheum. 2005;52:3381–3390.
  • Ahmed U, Anwar A, Savage RS, et al. Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health. Sci Rep. 2015;5:9259.
  • Nielsen SF, Bojesen SE, Schnohr P, et al. Elevated rheumatoid factor and long term risk of rheumatoid arthritis: a prospective cohort study. BMJ. 2012;345.
  • Liao H, Wu J, Kuhn E, et al. Use of mass spectrometry to identify protein biomarkers of disease severity in the synovial fluid and serum of patients with rheumatoid arthritis. Arthritis Rheum. 2004;50:3792–3803.
  • Rousseau JC, Delmas PD. Biological markers in osteoarthritis. Nat Clin Pract Rheumatol. 2007;3:346–356.
  • Thomas GP, Brown MA. Genetics and genomics of ankylosing spondylitis. Immunol Rev. 2010;233:162–180.
  • Castro C, Gourley M. Diagnostic testing and interpretation of tests for autoimmunity. J Allergy Clin Immunol. 2010;125:S238–SS47.
  • Qaseem A, McLean RM, Starkey M, et al. For the Clinical Guidelines Committee of the American College of P. Diagnosis of acute gout: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2017;66:52–57.
  • Ruiz-Romero C, Blanco FJ. Proteomics role in the search for improved diagnosis, prognosis and treatment of osteoarthritis. Osteoarthritis Cartilage. 2010;18:500–509.
  • Wilkinson M, Jones BS. Serum and synovial fluid proteins in arthritis. Ann Rheum Dis. 1962;21:51–58.
  • Parker CE, Borchers CH. Mass spectrometry based biomarker discovery, verification, and validation – quality assurance and control of protein biomarker assays. Mol Oncol. 2014;8:840–858.
  • Drabovich AP, Martinez-Morillo E, Diamandis EP. Toward an integrated pipeline for protein biomarker development. Biochim Biophys Acta. 2015;1854:677–686.
  • Cretu D, Prassas I, Saraon P, et al. Identification of psoriatic arthritis mediators in synovial fluid by quantitative mass spectrometry. Clin Proteomics. 2014;11:1–12.
  • Balakrishnan L, Bhattacharjee M, Ahmad S, et al. Differential proteomic analysis of synovial fluid from rheumatoid arthritis and osteoarthritis patients. Clin Proteomics. 2014;11:1.
  • Matsuo K, Xiang Y, Nakamura H, et al. Identification of novel citrullinated autoantigens of synovium in rheumatoid arthritis using a proteomic approach. Arthritis Res Ther. 2006;8:R175–R17R.
  • Marvin LF, Roberts MA, Fay LB. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in clinical chemistry. Clin Chim Acta. 2003;337:11–21.
  • Mateos J, Lourido L, Fernandez-Puente P, et al. Differential protein profiling of synovial fluid from rheumatoid arthritis and osteoarthritis patients using lc-maldi tof/tof. J Proteomics. 2012;75:2869–2878.
  • Gharbi M, Deberg M, Henrotin Y. Application for proteomic techniques in studying osteoarthritis: a review. Front Physiol. 2011;2:90.
  • Yates JR, Ruse CI, Nakorchevsky A. Proteomics by mass spectrometry: approaches, advances, and applications. Annu Rev Biomed Eng. 2009;11:49–79.
  • Chen G, Pramanik BN. Application of lc/ms to proteomics studies: current status and future prospects. Drug Discov Today. 2009;14:465–471.
  • Mann M. Functional and quantitative proteomics using silac. Nat Rev Mol Cell Biol. 2006;7:952–958.
  • Shiio Y, Aebersold R. Quantitative proteome analysis using isotope-coded affinity tags and mass spectrometry. Nat Protoc. 2006;1:139–145.
  • Wiese S, Reidegeld KA, Meyer HE, et al. Protein labeling by itraq: a new tool for quantitative mass spectrometry in proteome research. Proteomics. 2007;7:340–350.
  • Megger DA, Bracht T, Meyer HE, et al. Label-free quantification in clinical proteomics. Biochim Biophys Acta. 2013;1834:1581–1590.
  • Arike L, Peil L. Spectral counting label-free proteomics. Methods Mol Biol. 2014;1156:213–222.
  • Chelius D, Bondarenko PV. Quantitative profiling of proteins in complex mixtures using liquid chromatography and mass spectrometry. J Proteome Res. 2002;1:317–323.
  • Higgs RE, Knierman MD, Gelfanova V, et al. Comprehensive label-free method for the relative quantification of proteins from biological samples. J Proteome Res. 2005;4:1442–1450.
  • Wang Q, Rozelle AL, Lepus CM, et al. Identification of a central role for complement in osteoarthritis. Nat Med. 2011;17:1674–1679.
  • Livshits G, Zhai G, Hart DJ, et al. Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: the Chingford study. Arthritis Rheum. 2009;60:2037–2045.
  • Verma P, Dalal K. Serum cartilage oligomeric matrix protein (comp) in knee osteoarthritis: a novel diagnostic and prognostic biomarker. J Orthop Res. 2013;31:999–1006.
  • Maksymowych WP, Marotta A. 14-3-3η: a novel biomarker platform for rheumatoid arthritis. Clin Exp Rheumatol. 2014;32:S-35
  • Nordal HH, Brokstad KA, Solheim M, et al. Calprotectin (s100a8/a9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis. Arthritis Res Ther. 2017;19:3.
  • Hammer HB, Odegard S, Syversen SW, et al. Calprotectin (a major s100 leucocyte protein) predicts 10-year radiographic progression in patients with rheumatoid arthritis. Ann Rheum Dis. 2010;69:150–154.
  • Hammer HB, Ødeg̊ard S, Fagerhol MK, et al. Calprotectin (a major leucocyte protein) is strongly and independently correlated with joint inflammation and damage in rheumatoid arthritis. Ann Rheum Dis. 2007;66:1093–1097.
  • Balakrishnan L, Nirujogi RS, Ahmad S, et al. Proteomic analysis of human osteoarthritis synovial fluid. Clin Proteomics. 2014;11:6.
  • Gobezie R, Kho A, Krastins B, et al. High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis. Arthritis Res Ther. 2007;9:R36.
  • Hillmen P, Young NS, Schubert J, et al. The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med. 2006;355:1233–1243.
  • Brodsky RA, Young NS, Antonioli E, et al. Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria. Blood. 2008;111:1840–1847.
  • Wanner JP, Subbaiah R, Skomorovska-Prokvolit Y, et al. Proteomic profiling and functional characterization of early and late shoulder osteoarthritis. Arthritis Res Ther. 2013;15:R180.
  • Kokebie R, Aggarwal R, Lidder S, et al. The role of synovial fluid markers of catabolism and anabolism in osteoarthritis, rheumatoid arthritis and asymptomatic organ donors. Arthritis Res Ther. 2011;13:R50.
  • Tsuchida AI, Beekhuizen M, Rutgers M, et al. Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model. Arthritis Res Ther. 2012;14:R262.
  • Kaneko S, Satoh T, Chiba J, et al. Interleukin-6 and interleukin-8 levels in serum and synovial fluid of patients with osteoarthritis. Cytokines Cell Mol Ther. 2000;6:71–79.
  • El-Arman MM, El-Fayoumi G, El-Shal E, et al. Aggrecan and cartilage oligomeric matrix protein in serum and synovial fluid of patients with knee osteoarthritis. HSS J. 2010;6:171–176.
  • Biswas S, Sharma S, Saroha A, et al. Identification of novel autoantigen in the synovial fluid of rheumatoid arthritis patients using an immunoproteomics approach. PLoS One. 2013;8:e56246.
  • Young BJ, Mallya RK, Leslie RD, et al. Anti-keratin antibodies in rheumatoid arthritis. Br Med J. 1979;2:97–99.
  • Nielen MM, van Schaardenburg D, Reesink HW, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum. 2004;50:380–386.
  • Young KA, Deane KD, Derber LA, et al. Relatives without rheumatoid arthritis show reactivity to anti-citrullinated protein/peptide antibodies that are associated with arthritis-related traits: studies of the etiology of rheumatoid arthritis. Arthritis Rheum. 2013;65:1995–2004.
  • Kilani RT, Maksymowych WP, Aitken A, et al. Detection of high levels of 2 specific isoforms of 14-3-3 proteins in synovial fluid from patients with joint inflammation. J Rheumatol. 2007;34:1650–1657.
  • Hughes N, Boss S, Longe R, et al. Ab0079 independent validation of 14-3-3eta assay reproducibility, consistent with omeract soluble biomarker criteria. Ann Rheum Dis. 2015;74:917.
  • Segurado OG, Sasso EH. Vectra da for the objective measurement of disease activity in patients with rheumatoid arthritis. Clin Exp Rheumatol. 2014;32:S29–S34.
  • Bhattacharjee M, Sharma R, Goel R, et al. A multilectin affinity approach for comparative glycoprotein profiling of rheumatoid arthritis and spondyloarthropathy. Clin Proteomics. 2013;10:11.
  • Baillet A, Trocmé C, Berthier S, et al. Synovial fluid proteomic fingerprint: S100a8, s100a9 and s100a12 proteins discriminate rheumatoid arthritis from other inflammatory joint diseases. Rheumatology. 2010;49:671–682.
  • Sinz A, Bantscheff M, Mikkat S, et al. Mass spectrometric proteome analyses of synovial fluids and plasmas from patients suffering from rheumatoid arthritis and comparison to reactive arthritis or osteoarthritis. Electrophoresis. 2002;23:3445–3456.
  • Drynda S, Ringel B, Kekow M, et al. Proteome analysis reveals disease-associated marker proteins to differentiate ra patients from other inflammatory joint diseases with the potential to monitor anti-tnfalpha therapy. Pathol Res Pract. 2004;200:165–171.
  • Leach ST, Yang Z, Messina I, et al. Serum and mucosal s100 proteins, calprotectin (s100a8/s100a9) and s100a12, are elevated at diagnosis in children with inflammatory bowel disease. Scand J Gastroenterol. 2007;42:1321–1331.
  • Feldmann M, Brennan FM, Maini RN. Rheumatoid arthritis. Cell. 1996;85:307–310.
  • Yoshihara Y, Nakamura H, Obata K, et al. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis. Ann Rheum Dis. 2000;59:455–461.
  • Tchetverikov I, Ronday HK, Van El B, et al. Mmp profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis. Ann Rheum Dis. 2004;63:881–883.
  • Hemmings FJ, Farhan M, Rowland J, et al. Tolerability and pharmacokinetics of the collagenase-selective inhibitor trocade in patients with rheumatoid arthritis. Rheumatology (Oxford). 2001;40:537–543.
  • Lee DY, Huang CM, Nakatsuji T, et al. Histone h4 is a major component of the antimicrobial action of human sebocytes. J Invest Dermatol. 2009;129:2489–2496.
  • Dohrmann S, LaRock CN, Anderson EL, et al. Group a streptococcal m1 protein provides resistance against the antimicrobial activity of histones. Sci Rep. 2017;7:43039.
  • Vasey FB, Deitz C, Fenske NA, et al. Possible involvement of group a streptococci in the pathogenesis of psoriatic arthritis. J Rheumatol. 1982;9:719–722.
  • Scrivo R, Conigliaro P, Riccieri V, et al. Distribution of interleukin-10 family cytokines in serum and synovial fluid of patients with inflammatory arthritis reveals different contribution to systemic and joint inflammation. Clin Exp Immunol. 2015;179:300–308.
  • Kundu-Raychaudhuri S, Abria C, Raychaudhuri SP. Il-9, a local growth factor for synovial t cells in inflammatory arthritis. Cytokine. 2016;79:45–51.
  • Guggino G, Ciccia F, Di Liberto D, et al. Interleukin (il)-9/il-9r axis drives γδ T cells activation in psoriatic arthritis patients. Clin Exp Immunol. 2016;186:277–283.
  • Gibson DS, Finnegan S, Jordan G, et al. Stratification and monitoring of juvenile idiopathic arthritis patients by synovial proteome analysis. J Proteome Res. 2009;8:5601–5609.
  • Gibson DS, Blelock S, Brockbank S, et al. Proteomic analysis of recurrent joint inflammation in juvenile idiopathic arthritis. J Proteome Res. 2006;5:1988–1995.
  • Rosenkranz ME, Wilson DC, Marinov AD, et al. Synovial fluid proteins differentiate between the subtypes of juvenile idiopathic arthritis. Arthritis Rheum. 2010;62:1813–1823.
  • Gibson DS, Newell K, Evans AN, et al. Vitamin d binding protein isoforms as candidate predictors of disease extension in childhood arthritis. J Proteomics. 2012;75:5479–5492.
  • Blaschke S, Rinke K, Maring M, et al. Haptoglobin-α1, -α2, vitamin d-binding protein and apolipoprotein c-iii as predictors of etanercept drug response in rheumatoid arthritis. Arthritis Res Ther. 2015;17:45.
  • Diamandis EP. Cancer biomarkers: can we turn recent failures into success? J Natl Cancer Inst. 2010;102:1462–1467.

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