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Review Article

Body site-dependent variations of microbiota in pancreatic cancer pathophysiology

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Pages 260-273 | Received 07 Jan 2019, Accepted 02 May 2019, Published online: 06 Jun 2019

References

  • Ilic M, Ilic I. Epidemiology of pancreatic cancer. World J Gastroenterol. 2016;22:9694–9705.
  • Zhang X, Shi S, Zhang B, et al. Circulating biomarkers for early diagnosis of pancreatic cancer: facts and hopes. Am J Cancer Res. 2018;8:332–353.
  • Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.
  • Rahib L, Smith BD, Aizenberg R, et al. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 2014;74:2913–2921.
  • De La Cruz MS, Young AP, Ruffin MT. Diagnosis and management of pancreatic cancer. Am Fam Physician. 2014;89:626–632.
  • Moutinho-Ribeiro P, Iglesias-Garcia J, Gaspar R, et al. Early pancreatic cancer – the role of endoscopic ultrasound with or without tissue acquisition in diagnosis and staging. Dig Liver Dis. 2018;51(1):4–9.
  • Zhang L, Sanagapalli S, Stoita A. Challenges in diagnosis of pancreatic cancer. World J Gastroenterol. 2018;24:2047–2060.
  • Kamisawa T, Wood LD, Itoi T, et al. Pancreatic cancer. Lancet. 2016;388:73–85.
  • McGuigan A, Kelly P, Turkington RC, et al. Pancreatic cancer: a review of clinical diagnosis, epidemiology, treatment and outcomes. WJG. 2018;24:4846–4861.
  • Hruban RH, Canto MI, Goggins M, et al. Update on familial pancreatic cancer. Adv Surg. 2010;44:293–311.
  • Klein AP, Brune KA, Petersen GM, et al. Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds. Cancer Res. 2004;64:2634–2638.
  • Bansal P, Sonnenberg A. Pancreatitis is a risk factor for pancreatic cancer. Gastroenterology. 1995;109:247–251.
  • Raimondi S, Lowenfels AB, Morselli-Labate AM, et al. Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection. Best Pract Res Clin Gastroenterol. 2010;24:349–358.
  • Bracci PM. Obesity and pancreatic cancer: overview of epidemiologic evidence and biologic mechanisms. Mol Carcinog. 2012;51:53–63.
  • Li D, Morris JS, Liu J, et al. Body mass index and risk, age of onset, and survival in patients with pancreatic cancer. JAMA. 2009;301:2553–2562.
  • Bosetti C, Rosato V, Li D, et al. Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium. Ann Oncol. 2014;25:2065–2072.
  • Everhart J, Wright D. Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis. JAMA. 1995;273:1605–1609.
  • Iodice S, Gandini S, Maisonneuve P, et al. Tobacco and the risk of pancreatic cancer: a review and meta-analysis. Langenbecks Arch Surg. 2008;393:535–545.
  • Schulte A, Pandeya N, Tran B, et al. Cigarette smoking and pancreatic cancer risk: more to the story than just pack-years. Eur J Cancer. 2014;50:997–1003.
  • Larsson SC, Wolk A. Red and processed meat consumption and risk of pancreatic cancer: meta-analysis of prospective studies. Br J Cancer. 2012;106:603–607.
  • Nothlings U, Wilkens LR, Murphy SP, et al. Meat and fat intake as risk factors for pancreatic cancer: the multiethnic cohort study. J Natl Cancer Inst. 2005;97:1458–1465.
  • Gupta S, Wang F, Holly EA, et al. Risk of pancreatic cancer by alcohol dose, duration, and pattern of consumption, including binge drinking: a population-based study. Cancer Causes Control. 2010;21:1047–1059.
  • Wang YT, Gou YW, Jin WW, et al. Association between alcohol intake and the risk of pancreatic cancer: a dose-response meta-analysis of cohort studies. BMC Cancer. 2016;16:212.
  • Poruk KE, Firpo MA, Mulvihill SJ. Screening for pancreatic cancer. Adv Surg. 2014;48:115–136.
  • Loosen SH, Neumann UP, Trautwein C, et al. Current and future biomarkers for pancreatic adenocarcinoma. Tumour Biol. 2017;39:1010428317692231.
  • Kunovsky L, Tesarikova P, Kala Z, et al. The use of biomarkers in early diagnostics of pancreatic cancer. Can J Gastroenterol Hepatol. 2018;2018:5389820.
  • Neoptolemos JP, Kleeff J, Michl P, et al. Therapeutic developments in pancreatic cancer: current and future perspectives. Nat Rev Gastroenterol Hepatol. 2018;15:333–348.
  • Piątek M, Kuśnierz K, Bieńkowski M, et al. Primarily resectable pancreatic adenocarcinoma – to operate or to refer the patient to an oncologist? Crit Rev Oncol Hematol. 2019;135:95–102.
  • Martinez-Bosch N, Vinaixa J, Navarro P. Immune evasion in pancreatic cancer: from mechanisms to therapy. Cancers (Basel). 2018;10:E6.
  • Amrutkar M, Gladhaug IP. Pancreatic cancer chemoresistance to gemcitabine. Cancers (Basel). 2017;9:E157.
  • Hezel AF, Kimmelman AC, Stanger BZ, et al. Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev. 2006;20:1218–1249.
  • Kho ZY, Lal SK. The human gut microbiome – a potential controller of wellness and disease. Front Microbiol. 2018;9:1835.
  • Gerritsen J, Smidt H, Rijkers GT, et al. Intestinal microbiota in human health and disease: the impact of probiotics. Genes Nutr. 2011;6:209–240.
  • Shreiner AB, Kao JY, Young VB. The gut microbiome in health and in disease. Curr Opin Gastroenterol. 2015;31:69–75.
  • Boursi B, Mamtani R, Haynes K, et al. Recurrent antibiotic exposure may promote cancer formation – another step in understanding the role of the human microbiota? Eur J Cancer. 2015;51:2655–2664.
  • Bhatt AP, Redinbo MR, Bultman SJ. The role of the microbiome in cancer development and therapy. CA Cancer J Clin. 2017;67:326–344.
  • Panebianco C, Andriulli A, Pazienza V. Pharmacomicrobiomics: exploiting the drug-microbiota interactions in anticancer therapies. Microbiome. 2018;6:92.
  • Rajpoot M, Sharma AK, Sharma A, et al. Understanding the microbiome: emerging biomarkers for exploiting the microbiota for personalized medicine against cancer. Semin Cancer Biol. 2018;52:1–8.
  • Wong SH, Kwong TNY, Wu CY, et al. Clinical applications of gut microbiota in cancer biology. Semin Cancer Biol. 2018;55:28–36.
  • Chen J, Domingue JC, Sears CL. Microbiota dysbiosis in select human cancers: evidence of association and causality. Semin Immunol. 2017;32:25–34.
  • Panebianco C, Potenza A, Andriulli A, et al. Exploring the microbiota to better understand gastrointestinal cancers physiology. Clin Chem Lab Med. 2018;56:1400–1412.
  • Koppel N, Maini Rekdal V, Balskus EP. Chemical transformation of xenobiotics by the human gut microbiota. Science. 2017;356(6344):1–29. DOI:10.1126/science.aag2770
  • Lehouritis P, Cummins J, Stanton M, et al. Local bacteria affect the efficacy of chemotherapeutic drugs. Sci Rep. 2015;5:14554.
  • Rowland I, Gibson G, Heinken A, et al. Gut microbiota functions: metabolism of nutrients and other food components. Eur J Nutr. 2018;57:1–24. DOI:10.1007/s00394-017-1445-8
  • Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation. Cell. 2014;157:121–141.
  • Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science. 2012;336:1268–1273.
  • Leal-Lopes C, Velloso FJ, Campopiano JC, et al. Roles of commensal microbiota in pancreas homeostasis and pancreatic pathologies. J Diabetes Res. 2015;2015:284680.
  • Chen D, Wu J, Jin D, et al. Fecal microbiota transplantation in cancer management: current status and perspectives. Int J Cancer. 2018. DOI:10.1002/ijc.32003
  • Pevsner-Fischer M, Tuganbaev T, Meijer M, et al. Role of the microbiome in non-gastrointestinal cancers. World J Clin Oncol. 2016;7:200–213.
  • Raderer M, Wrba F, Kornek G, et al. Association between Helicobacter pylori infection and pancreatic cancer. Oncology. 1998;55:16–19.
  • Kusters JG, van Vliet AH, Kuipers EJ. Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev. 2006;19:449–490.
  • Hooi JKY, Lai WY, Ng WK, et al. Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology. 2017;153:420–429.
  • Zamani M, Ebrahimtabar F, Zamani V, et al. Systematic review with meta-analysis: the worldwide prevalence of Helicobacter pylori infection. Aliment Pharmacol Ther. 2018;47:868–876.
  • Yoshiyama H, Nakazawa T. Unique mechanism of Helicobacter pylori for colonizing the gastric mucus. Microbes Infect. 2000;2:55–60.
  • Nardone G, Compare D. The human gastric microbiota: is it time to rethink the pathogenesis of stomach diseases? United European Gastroenterol J. 2015;3:255–260.
  • Yang I, Nell S, Suerbaum S. Survival in hostile territory: the microbiota of the stomach. FEMS Microbiol Rev. 2013;37:736–761.
  • Andersson AF, Lindberg M, Jakobsson H, et al. Comparative analysis of human gut microbiota by barcoded pyrosequencing. PLoS One. 2008;3:e2836.
  • Bik EM, Eckburg PB, Gill SR, et al. Molecular analysis of the bacterial microbiota in the human stomach. Proc Natl Acad Sci USA. 2006;103:732–737.
  • Noto JM, Peek RM Jr. The gastric microbiome, its interaction with Helicobacter pylori, and its potential role in the progression to stomach cancer. PLoS Pathog. 2017;13:e1006573.
  • Parsonnet J, Friedman GD, Vandersteen DP, et al. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med. 1991;325:1127–1131.
  • Stolte M. Helicobacter pylori gastritis and gastric MALT-lymphoma. Lancet. 1992;339:745–746.
  • Ding SZ, Goldberg JB, Hatakeyama M. Helicobacter pylori infection, oncogenic pathways and epigenetic mechanisms in gastric carcinogenesis. Future Oncol. 2010;6:851–862.
  • Lu H, Yamaoka Y, Graham DY. Helicobacter pylori virulence factors: facts and fantasies. Curr Opin Gastroenterol. 2005;21:653–659.
  • Stolzenberg-Solomon RZ, Blaser MJ, Limburg PJ, et al. Helicobacter pylori seropositivity as a risk factor for pancreatic cancer. J Natl Cancer Inst. 2001;93:937–941.
  • Lindkvist B, Johansen D, Borgstrom A, et al. A prospective study of Helicobacter pylori in relation to the risk for pancreatic cancer. BMC Cancer. 2008;8:321.
  • Risch HA, Yu H, Lu L, et al. ABO blood group, Helicobacter pylori seropositivity, and risk of pancreatic cancer: a case-control study. J Natl Cancer Inst. 2010;102:502–505.
  • Risch HA, Lu L, Kidd MS, et al. Helicobacter pylori seropositivities and risk of pancreatic carcinoma. Cancer Epidemiol Biomarkers Prev. 2014;23:172–178.
  • Ai F, Hua X, Liu Y, et al. Preliminary study of pancreatic cancer associated with Helicobacter pylori infection. Cell Biochem Biophys. 2015;71:397–400.
  • Chen XZ, Schottker B, Castro FA, et al. Association of Helicobacter pylori infection and chronic atrophic gastritis with risk of colonic, pancreatic and gastric cancer: a ten-year follow-up of the ESTHER cohort study. Oncotarget. 2016;7:17182–17193.
  • de Martel C, Llosa AE, Friedman GD, et al. Helicobacter pylori infection and development of pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2008;17:1188–1194.
  • Gawin A, Wex T, Ławniczak M, et al. Helicobacter pylori infection in pancreatic cancer. Pol Merkur Lekarski. 2012;32:103–107.
  • Huang J, Zagai U, Hallmans G, et al. Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: a nested case-control study. Int J Cancer. 2017;140:1727–1735.
  • Schulte A, Pandeya N, Fawcett J, et al. Association between Helicobacter pylori and pancreatic cancer risk: a meta-analysis. Cancer Causes Control. 2015;26:1027–1035.
  • Yu G, Murphy G, Michel A, et al. Seropositivity to Helicobacter pylori and risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2013;22:2416–2419.
  • Guo Y, Liu W, Wu J. Helicobacter pylori infection and pancreatic cancer risk: a meta-analysis. J Cancer Res Ther. 2016;12:C229–C232.
  • Trikudanathan G, Philip A, Dasanu CA, et al. Association between Helicobacter pylori infection and pancreatic cancer. A cumulative meta-analysis. JOP. 2011;12:26–31.
  • Xiao M, Wang Y, Gao Y. Association between Helicobacter pylori infection and pancreatic cancer development: a meta-analysis. PLoS One. 2013;8:e75559.
  • Liu H, Chen YT, Wang R, et al. Helicobacter pylori infection, atrophic gastritis, and pancreatic cancer risk: a meta-analysis of prospective epidemiologic studies. Medicine (Baltimore). 2017;96:e7811.
  • Wang Y, Zhang FC, Wang YJ. Helicobacter pylori and pancreatic cancer risk: a meta- analysis based on 2,049 cases and 2,861 controls. Asian Pac J Cancer Prev. 2014;15:4449–4454.
  • Chen XZ, Wang R, Chen HN, et al. Cytotoxin-associated gene A-negative strains of Helicobacter pylori as a potential risk factor of pancreatic cancer: a meta-analysis based on nested case-control studies. Pancreas. 2015;44:1340–1344.
  • Bulajic M, Panic N, Lohr JM. Helicobacter pylori and pancreatic diseases. WJGP. 2014;5:380–383.
  • Nilsson HO, Stenram U, Ihse I, et al. Helicobacter species ribosomal DNA in the pancreas, stomach and duodenum of pancreatic cancer patients. WJG. 2006;12:3038–3043.
  • Takayama S, Takahashi H, Matsuo Y, et al. Effects of Helicobacter pylori infection on human pancreatic cancer cell line. Hepatogastroenterology. 2007;54:2387–2391.
  • Avila M, Ojcius DM, Yilmaz O. The oral microbiota: living with a permanent guest. DNA Cell Biol. 2009;28:405–411.
  • Jia G, Zhi A, Lai PFH, et al. The oral microbiota – a mechanistic role for systemic diseases. Br Dent J. 2018;224:447–455.
  • Dewhirst FE, Chen T, Izard J, et al. The human oral microbiome. J Bacteriol. 2010;192:5002–5017.
  • Sultan AS, Kong EF, Rizk AM, et al. The oral microbiome: a lesson in coexistence. PLoS Pathog. 2018;14:e1006719.
  • Hujoel PP, Drangsholt M, Spiekerman C, et al. An exploration of the periodontitis–cancer association. Ann Epidemiol. 2003;13:312–316.
  • Michaud DS, Joshipura K, Giovannucci E, et al. A prospective study of periodontal disease and pancreatic cancer in US male health professionals. J Natl Cancer Inst. 2007;99:171–175.
  • Stolzenberg-Solomon RZ, Dodd KW, Blaser MJ, et al. Tooth loss, pancreatic cancer, and Helicobacter pylori. Am J Clin Nutr. 2003;78:176–181.
  • Lin IH, Wu J, Coehn SM, et al. Pilot study of oral microbiome and risk of pancreatic cancer. In: 104th Annual Meeting of the American Association for Cancer Research; 2013; Washington, DC, Philadelphia.
  • Farrell JJ, Zhang L, Zhou H, et al. Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer. Gut. 2012;61:582–588.
  • Michaud DS, Izard J, Wilhelm-Benartzi CS, et al. Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study. Gut. 2013;62:1764–1770.
  • Torres PJ, Fletcher EM, Gibbons SM, et al. Characterization of the salivary microbiome in patients with pancreatic cancer. PeerJ. 2015;3:e1373.
  • Fan X, Alekseyenko AV, Wu J, et al. Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study. Gut. 2018;67:120–127.
  • Olson SH, Satagopan J, Xu Y, et al. The oral microbiota in patients with pancreatic cancer, patients with IPMNs, and controls: a pilot study. Cancer Causes Control. 2017;28:959–969.
  • Vaz J, Andersson R. Intervention on toll-like receptors in pancreatic cancer. World J Gastroenterol. 2014;20:5808–5817.
  • Zambirinis CP, Levie E, Nguy S, et al. TLR9 ligation in pancreatic stellate cells promotes tumorigenesis. J Exp Med. 2015;212:2077–2094.
  • Chung LM, Liang JA, Lin CL, et al. Cancer risk in patients with candidiasis: a nationwide population-based cohort study. Oncotarget. 2017;8:63562–63573.
  • Huang J, Roosaar A, Axell T, et al. A prospective cohort study on poor oral hygiene and pancreatic cancer risk. Int J Cancer. 2016;138:340–347.
  • Krogh P. The role of yeasts in oral cancer by means of endogenous nitrosation. Acta Odontol Scand. 1990;48:85–88.
  • Ramirez-Garcia A, Rementeria A, Aguirre-Urizar JM, et al. Candida albicans and cancer: can this yeast induce cancer development or progression? Crit Rev Microbiol. 2016;42:181–193.
  • Gustafson KS, Vercellotti GM, Bendel CM, et al. Molecular mimicry in Candida albicans. Role of an integrin analogue in adhesion of the yeast to human endothelium. J Clin Invest. 1991;87:1896–1902.
  • Schwabe RF, Jobin C. The microbiome and cancer. Nat Rev Cancer. 2013;13:800–812.
  • Tanca A, Manghina V, Fraumene C, et al. Metaproteogenomics reveals taxonomic and functional changes between cecal and fecal microbiota in mouse. Front Microbiol. 2017;8:391.
  • Tropini C, Earle KA, Huang KC, et al. The gut microbiome: connecting spatial organization to function. Cell Host Microbe. 2017;21:433–442.
  • Thomas V, Clark J, Dore J. Fecal microbiota analysis: an overview of sample collection methods and sequencing strategies. Future Microbiol. 2015;10:1485–1504.
  • Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464:59–65.
  • Half E, Keren N, Dorfman T, et al. Specific changes in fecal microbiota may differentiate pancreatic cancer patients from healthy individuals. Ann Oncol. 2015;26:iv48.
  • Ren Z, Jiang J, Xie H, et al. Gut microbial profile analysis by MiSeq sequencing of pancreatic carcinoma patients in China. Oncotarget. 2017;8:95176–95191.
  • Mei QX, Huang CL, Luo SZ, et al. Characterization of the duodenal bacterial microbiota in patients with pancreatic head cancer vs. healthy controls. Pancreatology. 2018;18:438–445.
  • Rogers MB, Aveson V, Firek B, et al. Disturbances of the perioperative microbiome across multiple body sites in patients undergoing pancreaticoduodenectomy. Pancreas. 2017;46:260–267.
  • Panebianco C, Adamberg K, Adamberg S, et al. Engineered resistant-starch (ERS) diet shapes colon microbiota profile in parallel with the retardation of tumor growth in in vitro and in vivo pancreatic cancer models. Nutrients. 2017;9:E331.
  • Pushalkar S, Hundeyin M, Daley D, et al. The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression. Cancer Discov. 2018;8:403–416.
  • Sethi V, Kurtom S, Tarique M, et al. Gut microbiota promotes tumor growth in mice by modulating immune response. Gastroenterology. 2018;155:33–37e36.
  • Thomas RM, Gharaibeh RZ, Gauthier J, et al. Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models. Carcinogenesis. 2018;39(8):1068–1078.
  • Pagliari D, Saviano A, Newton EE, et al. Gut microbiota–immune system crosstalk and pancreatic disorders. Mediators Inflamm. 2018;2018:7946431.
  • Scheithauer BK, Wos-Oxley ML, Ferslev B, et al. Characterization of the complex bacterial communities colonizing biliary stents reveals a host-dependent diversity. ISME J. 2009;3:797–807.
  • Schneider J, Schenk P, Obermeier A, et al. Microbial colonization of pancreatic duct stents. A prospective analysis. Pancreas. 2015;44:786–790.
  • Swidsinski A, Schlien P, Pernthaler A, et al. Bacterial biofilm within diseased pancreatic and biliary tracts. Gut. 2005;54:388–395.
  • Li S, Fuhler GM, Bn N, et al. Pancreatic cyst fluid harbors a unique microbiome. Microbiome. 2017;5:147.
  • Castellarin M, Warren RL, Freeman JD, et al. Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res. 2012;22:299–306.
  • Kostic AD, Gevers D, Pedamallu CS, et al. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 2012;22:292–298.
  • Mitsuhashi K, Nosho K, Sukawa Y, et al. Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis. Oncotarget. 2015;6:7209–7220.
  • Del Castillo E, Meier R, Chung M, et al. The microbiomes of pancreatic and duodenum tissue overlap and are highly subject specific but differ between pancreatic cancer and non-cancer subjects. Cancer Epidemiol Biomarkers Prev. 2019;28:370–383.
  • Geller LT, Barzily-Rokni M, Danino T, et al. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017;357:1156–1160.
  • Nistal E, Caminero A, Herran AR, et al. Differences of small intestinal bacteria populations in adults and children with/without celiac disease: effect of age, gluten diet, and disease. Inflamm Bowel Dis. 2012;18:649–656.
  • Hayashi C, Gudino CV, Gibson FC 3rd, et al. Review: pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways. Mol Oral Microbiol. 2010;25:305–316.
  • LaMonte MJ, Genco RJ, Hovey KM, et al. History of periodontitis diagnosis and edentulism as predictors of cardiovascular disease, stroke, and mortality in postmenopausal women. J Am Heart Assoc. 2017;6(4):1–11. DOI:10.1161/JAHA.116.004518
  • Zambirinis CP, Pushalkar S, Saxena D, et al. Pancreatic cancer, inflammation, and microbiome. Cancer J. 2014;20:195–202.
  • Karley D, Gupta D, Tiwari A. Biomarker for cancer: a great promise for future. World J Oncol. 2011;2:151–157.
  • Rintala A, Pietila S, Munukka E, et al. Gut microbiota analysis results are highly dependent on the 16S rRNA gene target region, whereas the impact of DNA extraction is minor. J Biomol Techn. 2017;28:19–30.
  • Conlon MA, Bird AR. The impact of diet and lifestyle on gut microbiota and human health. Nutrients. 2014;7:17–44.
  • Mueller S, Saunier K, Hanisch C, et al. Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Appl Environ Microbiol. 2006;72:1027–1033.
  • Goodrich JK, Di Rienzi SC, Poole AC, et al. Conducting a microbiome study. Cell. 2014;158:250–262.
  • Sinha R, Chen J, Amir A, et al. Collecting fecal samples for microbiome analyses in epidemiology studies. Cancer Epidemiol Biomarkers Prev. 2016;25:407–416.
  • Chang JH, Jiang Y, Pillarisetty VG. Role of immune cells in pancreatic cancer from bench to clinical application: an updated review. Medicine (Baltimore). 2016;95:e5541.
  • Goodman B, Gardner H. The microbiome and cancer. J Pathol. 2018;244:667–676.
  • Zhao H, Chu M, Huang Z, et al. Variations in oral microbiota associated with oral cancer. Sci Rep. 2017;7:11773.

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