Biochemical markers of time since death in cerebrospinal fluid: A first step towards “Forensomics”

References

• Madea B. Estimation of the time since death. 3rd ed. Boca Raton (FL): CRC Press; 2015.
   Google Scholar
• Donaldson AE, Lamont IL. Estimation of post-mortem interval using biochemical markers. Aust J Forensic Sci. 2014;46:8–26.
   Web of Science ®Google Scholar
• Swain R, Kumar A, Sahoo J, et al. Estimation of post-mortem interval: a comparison between cerebrospinal fluid and vitreous humour chemistry. J Forensic Leg Med. 2015;36:144–148.
   PubMed Web of Science ®Google Scholar
• Zhou C, Byard RW. Factors and processes causing accelerated decomposition in human cadavers—an overview. J Forensic Leg Med. 2011;18:6–9.
   PubMed Web of Science ®Google Scholar
• Coe JI. Postmortem chemistry update. Emphasis on forensic application. Am J Forensic Med Pathol. 1993;14:91–117.
   PubMed Web of Science ®Google Scholar
• Madea B. Methods for determining time of death. Forensic Sci Med Pathol. 2016;12:451–485.
   PubMed Web of Science ®Google Scholar
• Madea B. Is there recent progress in the estimation of the postmortem interval by means of thanatochemistry? Forensic Sci Int. 2005;151:139–149.
   PubMed Web of Science ®Google Scholar
• Henry JB, Smith FA. Estimation of the postmortem interval by chemical means. Am J Forensic Med Pathol. 1980;1:341–347.
   PubMed Web of Science ®Google Scholar
• Wyler D, Marty W, Bär W. Correlation between the post-mortem cell content of cerebrospinal fluid and time of death. Int J Legal Med. 1994;106:194–199.
   PubMed Web of Science ®Google Scholar
• Palmiere C, Mangin P. Postmortem chemistry update part I. Int J Legal Med. 2012;126:187–198.
   PubMed Web of Science ®Google Scholar
• Palmiere C, Mangin P. Postmortem chemistry update part II. Int J Legal Med. 2012;126:199–215.
   PubMedGoogle Scholar
• Arroyo A, Rosel P, Marron T. Cerebrospinal fluid: postmortem biochemical study. J Clin Forensic Med. 2005;12:153–156.
   PubMedGoogle Scholar
• Yadav J, Deshpande A, Arora A, et al. Estimation of time since death from CSF electrolyte concentration in Bhopal region of central India. Leg Med Tokyo Jpn. 2007;9:309–313.
   PubMedGoogle Scholar
• Mason JK, Klyne W, Lennox B. Potassium levels in the cerebrospinal fluid after death. J Clin Pathol. 1951;4:231–233.
   PubMed Web of Science ®Google Scholar
• Murray E. Potassium levels in cerebrospinal fluid and their relation to duration of death. J Forensic Sci. 1958;3:480–485.
   Google Scholar
• Naumann HN. Cerebrospinal fluid electrolytes after death. Proc Soc Exp Biol Med. 1958;98:16–18.
   PubMed Web of Science ®Google Scholar
• Naumann HN. Postmortem chemistry of the vitreous body in man. Arch Ophthalmol. 1959;62:356–363.
   PubMedGoogle Scholar
• Fraschini F, Muller E, Zanoboni A. Post-mortem increase of potassium in human cerebrospinal fluid. Nature. 1963;198:1208.
   PubMed Web of Science ®Google Scholar
• Schleyer F. Methods of forensic science. Vol. 2, New York (NY): Wiley; 1963.
   Google Scholar
• Paulson GW, Stickney D. Cerebrospinal fluid after death. Confin Neurol. 1971;33:149–162.
   PubMedGoogle Scholar
• Kärkelä JT. Critical evaluation of postmortem changes in human autopsy cisternal fluid. Enzymes, electrolytes, acid-base balance, glucose and glycolysis, free amino acids and ammonia. Correlation to total brain ischemia. J Forensic Sci. 1993;38:603–616.
   PubMed Web of Science ®Google Scholar
• Eliakis E, Eliakis A, Coutselinis A. Fluctuations des électrolytes du liquide céphalo-rachidien après la mort et leur signification pour la détermination du moment du décès. Ann Méd lég. 1966;46(2):108–111.
   Google Scholar
• Eliakis E, Eliakis A, Coutselinis A. Détermination de l’heure de la mort par le dosage du phosphore inorganique du liquide cérébro-spinal. Ann Méd lég. 1965;45(4):366–371.
   Google Scholar
• Naumann HN. Studies on postmortem chemistry. Am J Clin Pathol. 1950;20:314–324.
   PubMed Web of Science ®Google Scholar
• Nixon DA. Cerebrospinal fluid inositol and its rise in post-mortem specimens. J Physiol (Lond). 1955;129:272–280.
   Google Scholar
• Pucher G, Burd L. A preliminary study of the chemistry of postmortem blood and spinal fluid. Bull Buffalo Gen Hosp. 1925;3:11–13.
   Google Scholar
• Kärkelä J, Scheinin M. Tryptophan and biogenic amine metabolites in post-mortem human cisternal fluid: effects of post-mortem interval and agonal time. J Neurol Sci. 1992;107:239–245.
   PubMed Web of Science ®Google Scholar
• Girela E, Villanueva E, Irigoyen P, et al. Free amino acid concentrations in vitreous humor and cerebrospinal fluid in relation to the cause of death and postmortem interval. J Forensic Sci. 2008;53:730–733.
   PubMed Web of Science ®Google Scholar
• Jenkins WJ. The significance of blood and cerebrospinal fluid urea levels estimated after death. J Clin Pathol. 1953;6:110–113.
   PubMed Web of Science ®Google Scholar
• Fekete JF, Brunsdon D. The use of routine laboratory tests in postmortem examinations. Can Soc Forensic Sci J. 1974;7:238–254.
   Google Scholar
• Endo T, Hara S, Kuriiwa F, et al. Postmortem changes in the levels of monoamine metabolites in human cerebrospinal fluid. Forensic Sci Int. 1990;44:61–68.
   PubMed Web of Science ®Google Scholar
• Balbi T, Fusco M, Vasapollo D, et al. The presence of trace amines in postmortem cerebrospinal fluid in humans. J Forensic Sci. 2005;50:630–632.
   PubMed Web of Science ®Google Scholar
• Musshoff F, Menting T, Madea B. Postmortem serotonin (5-HT) concentrations in the cerebrospinal fluid of medicolegal cases. Forensic Sci Int. 2004;142:211–219.
   PubMed Web of Science ®Google Scholar
• Dogan KH, Unaldi M, Demirci S. Evaluation of postmortem cerebrospinal fluid S100B protein and serotonin levels: comparison of suicidal versus nonsuicidal deaths in Konya, Turkey. J Forensic Sci. 2016;61:1285–1291.
   PubMed Web of Science ®Google Scholar
• Quan L, Ishikawa T, Hara J, et al. Postmortem serotonin levels in cerebrospinal and pericardial fluids with regard to the cause of death in medicolegal autopsy. Leg Med Tokyo Jpn. 2011;13:75–78.
   PubMed Web of Science ®Google Scholar
• Takata T, Kitao T, Miyaishi S. Relationship between post-mortem interval and creatine concentration in vitreous humour and cerebrospinal fluid. Aust J Forensic Sci. 2014;46:160–165.
   Web of Science ®Google Scholar
• Harkness RA, Lund RJ. Cerebrospinal fluid concentrations of hypoxanthine, xanthine, uridine and inosine: high concentrations of the ATP metabolite, hypoxanthine, after hypoxia. J Clin Pathol. 1983;36:1–8.
   PubMed Web of Science ®Google Scholar
• Manzke H, Krämer M, Dörner K. Post-mortem oxypurine concentrations in the CSF. Adv Exp Med Biol. 1986;195 Pt A:587–591.
   PubMedGoogle Scholar
• Madea B, Käferstein H, Hermann N, et al. Hypoxanthine in vitreous humor and cerebrospinal fluid–a marker of postmortem interval and prolonged (vital) hypoxia? Remarks also on hypoxanthine in SIDS. Forensic Sci Int. 1994;65:19–31.
   PubMed Web of Science ®Google Scholar
• Praetorius E, Poulsen H, Dupont H. Uric acid, xanthine and hypoxanthine in the cerebrospinal fluid. Scand J Clin Lab Invest. 1957;9:133–137.
   PubMed Web of Science ®Google Scholar
• Carpenter KH, Bonham JR, Worthy E, et al. Vitreous humour and cerebrospinal fluid hypoxanthine concentration as a marker of pre-mortem hypoxia in SIDS. J Clin Pathol. 1993;46:650–653.
   PubMed Web of Science ®Google Scholar
• Morris JA, Harrison LM, Telford DR. Postmortem cerebrospinal fluid pleocytosis: a marker of inflammation or postmortem artifact? Int J Pediatr. 2012;2012:964074.
   PubMedGoogle Scholar
• Mangin P, Lugnier AA, Chaumont AJ, et al. Forensic significance of postmortem estimation of the blood cerebrospinal fluid barrier permeability. Forensic Sci Int. 1983;22:143–149.
   PubMed Web of Science ®Google Scholar
• Morihara T, Kudo T, Ikura Y, et al. Increased tau protein level in postmortem cerebrospinal fluid. Psychiatry Clin Neurosci. 1998;52:107–110.
   PubMed Web of Science ®Google Scholar
• Osuna E, Perez-Carceles MD, Luna A, et al. Efficacy of cerebro-spinal fluid biochemistry in the diagnosis of brain insult. Forensic Sci Int. 1992;52:193–198.
   PubMed Web of Science ®Google Scholar
• Finehout EJ, Franck Z, Relkin N, et al. Proteomic analysis of cerebrospinal fluid changes related to postmortem interval. Clin Chem. 2006;52:1906–1913.
   PubMed Web of Science ®Google Scholar
• Maeda H, Michiue T, Zhu B-L, et al. Analysis of cardiac troponins and creatine kinase MB in cerebrospinal fluid in medicolegal autopsy cases. Leg Med Tokyo Jpn. 2009;11:S266–S268.
   PubMedGoogle Scholar
• Wang Q, Michiue T, Ishikawa T, et al. Combined analyses of creatine kinase MB, cardiac troponin I and myoglobin in pericardial and cerebrospinal fluids to investigate myocardial and skeletal muscle injury in medicolegal autopsy cases. Leg Med Tokyo Jpn. 2011;13:226–232.
   PubMed Web of Science ®Google Scholar
• Chen J-H, Inamori-Kawamoto O, Michiue T, et al. Cardiac biomarkers in blood, and pericardial and cerebrospinal fluids of forensic autopsy cases: a reassessment with special regard to postmortem interval. Leg Med Tokyo Jpn. 2015;17:343–350.
   PubMed Web of Science ®Google Scholar
• Dito WR. Transaminase activity in postmortem cerebrospinal fluid. Am J Clin Pathol. 1964;42:360–363.
   PubMed Web of Science ®Google Scholar
• Fan K. 2', 3'-cyclic nucleotide 3'-phosphohydrolase activity in postmortem human spinal fluids. Neurosci Lett. 1980;19:229–233.
   PubMed Web of Science ®Google Scholar
• Parmar AK, Menon SK. Estimation of postmortem interval through albumin in CSF by simple dye binding method. Sci Justice. 2015;55:388–393.
   PubMed Web of Science ®Google Scholar
• Li D-R, Michiue T, Zhu B-L, et al. Evaluation of postmortem S100B levels in the cerebrospinal fluid with regard to the cause of death in medicolegal autopsy. Leg Med (Tokyo). 2009;11 Suppl:1:S273–S275.
   PubMedGoogle Scholar
• Wester P, Bateman DE, Dodd PR, et al. Agonal status affects the metabolic activity of nerve endings isolated from postmortem human brain. Neurochem Pathol. 1985;3:169–180.
   PubMedGoogle Scholar
• Sommer JB, Gaul C, Heckmann J, et al. Does lumbar cerebrospinal fluid reflect ventricular cerebrospinal fluid? A prospective study in patients with external ventricular drainage. Eur Neurol. 2002;47:224–232.
   PubMed Web of Science ®Google Scholar
• Weisner B, Bernhardt W. Protein fractions of lumbar, cisternal, and ventricular cerebrospinal fluid. Separate areas of reference. J Neurol Sci. 1978;37:205–214.
   PubMed Web of Science ®Google Scholar
• Reiber H. Dynamics of brain-derived proteins in cerebrospinal fluid. Clin Chim Acta. 2001;310:173–186.
   PubMed Web of Science ®Google Scholar
• Young SN, Garelis E, Lal S, et al. Tryptophan and 5-hydroxyindoleacetic acid in human cerebrospinal fluid. J Neurochem. 1974;22:777–779.
   PubMed Web of Science ®Google Scholar
• Nordin C, Siwers B, Bertilsson L. Site of lumbar puncture influences levels of monoamine metabolites. Arch Gen Psychiatry. 1982;39:1445.
   PubMed Web of Science ®Google Scholar
• Garland J, Philcox W, Kesha K, et al. Differences in sampling site on postmortem cerebrospinal fluid biochemistry: a preliminary study. Am J Forensic Med Pathol. 2018;39:304–308.
   PubMed Web of Science ®Google Scholar
• Schoonenboom NSM, Mulder C, Vanderstichele H, et al. Effects of processing and storage conditions on amyloid beta (1-42) and tau concentrations in cerebrospinal fluid: implications for use in clinical practice. Clin Chem. 2004;51:189–195.
   PubMed Web of Science ®Google Scholar
• Mattsson N, Andreasson U, Persson S, et al. CSF biomarker variability in the Alzheimer’s Association quality control program. Alzheimers Dement. 2013;9:251–261.
   PubMed Web of Science ®Google Scholar
• Teunissen CE, Verwey NA, Kester MI, et al. Standardization of assay procedures for analysis of the CSF biomarkers amyloid β((1-42)), tau, and phosphorylated tau in Alzheimer’s disease: report of an international workshop. Int J Alzheimers Dis. 2010;2010:635053.
   PubMedGoogle Scholar
• Wu A. Tietz clinical guide to laboratory tests. 4th ed. St. Louis (MO): Saunders; 2006.
   Google Scholar
• Sjögren M, Vanderstichele H, Agren H, et al. Tau and Abeta42 in cerebrospinal fluid from healthy adults 21-93 years of age: establishment of reference values. Clin Chem. 2001;47:1776–1781.
   PubMed Web of Science ®Google Scholar
• Henssge C. Death time estimation in case work. I. The rectal temperature time of death nomogram. Forensic Sci Int. 1988;38:209–236.
   PubMed Web of Science ®Google Scholar
• Henssge C, Madea B, Gallenkemper E. Death time estimation in case work. II. Integration of different methods. Forensic Sci Int. 1988;39:77–87.
   PubMed Web of Science ®Google Scholar
• Henssge C. Rectal temperature time of death nomogram: dependence of corrective factors on the body weight under stronger thermic insulation conditions. Forensic Sci Int. 1992;54:51–66.
   PubMed Web of Science ®Google Scholar
• Henssge C, Althaus L, Bolt J, et al. Experiences with a compound method for estimating the time since death. I. Rectal temperature nomogram for time since death. Int J Legal Med. 2000;113:303–319.
   PubMed Web of Science ®Google Scholar
• Henssge C, Althaus L, Bolt J, et al. Experiences with a compound method for estimating the time since death. II. Integration of non-temperature-based methods. Int J Legal Med. 2000;113:320–331.
   PubMed Web of Science ®Google Scholar
• Baccino E, Martin LDS, Schuliar Y, et al. Outer ear temperature and time of death. Forensic Sci Int. 1996;83:133–146.
   PubMed Web of Science ®Google Scholar
• Cattaneo C, Di Giancamillo A, Campari O, et al. Infrared tympanic thermography as a substitute for a probe in the evaluation of ear temperature for post-mortem interval determination: a pilot study. J Forensic Leg Med. 2009;16:215–217.
   PubMed Web of Science ®Google Scholar
• Camps F. Establishment of the time of death—a critical assessment. J Forensic Sci. 1959;4:73–82.
   Google Scholar
• Madea B. Estimation of the time since death. In: Siegel JA, Saukko PJ, editors. Encyclopedia of forensic sciences. Waltham (MA): Academic Press; 2013. p. 229–238.
   Google Scholar
• Boja ES, Kinsinger CR, Rodriguez H, et al. Integration of omics sciences to advance biology and medicine. Clin Proteomics. 2014;11:45.
   Web of Science ®Google Scholar