The potential impact of salivary peptides in periodontitis

References

• Mariotti A, Hefti AF. Defining periodontal health. BMC Oral Health. 2015;15(Suppl 1):S6.
   PubMedGoogle Scholar
• Highfield J. Diagnosis and classification of periodontal disease. Aust Dent J. 2009;54(Suppl 1):11–26.
   Google Scholar
• Marchesan JT, Byrd KM, Moss K, et al. Flossing is associated with improved oral health in older adults. J Dent Res. 2020;99(9):1047–1053.
   PubMed Web of Science ®Google Scholar
• Syrjäläinen S, Gursoy UK, Gursoy M, et al. Salivary cytokine biomarker concentrations in relation to obesity and periodontitis. J Clin Med. 2019;8(12):2152.
   Web of Science ®Google Scholar
• Ming J, Zhuoneng L, Guangxun Z. Protective role of flavonoid baicalin from Scutellaria baicalensis in periodontal disease pathogenesis: a literature review. Complement Ther Med. 2018;38:11–18.
   PubMed Web of Science ®Google Scholar
• Sanz M, Marco Del Castillo A, Jepsen S, et al. Periodontitis and cardiovascular diseases: consensus report. J Clin Periodontol. 2020;47(3):268–288.
   PubMed Web of Science ®Google Scholar
• Dahlen G, Basic A, Bylund J. Importance of virulence factors for the persistence of oral bacteria in the inflamed gingival crevice and in the pathogenesis of periodontal disease. J Clin Med. 2019;8(9):1339.jcm. 8091339.
   PubMed Web of Science ®Google Scholar
• Barros SP, Williams R, Offenbacher S, et al. Gingival crevicular fluid as a source of biomarkers for periodontitis. Periodontol. 2016;70(1):53–64.
   Google Scholar
• Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Periodontol. 2018;89(Suppl 1):S159–S172.
   PubMed Web of Science ®Google Scholar
• Pitiphat W, Merchant AT, Rimm EB, et al. Alcohol consumption increases periodontitis risk. J Dent Res. 2003;82(7):509–513.
   PubMed Web of Science ®Google Scholar
• Radzi AM, Tan SS, Mohamed R, et al. Hepatitis screening and treatment campaign in malaysia-validation of low-cost point of care screening tests and nucleic acid tests for hepatitis B and C. Euroasian J Hepatogastroenterol. 2018;8(2):101–107.
   PubMedGoogle Scholar
• Frencken JE, Sharma P, Stenhouse L, et al. Global epidemiology of dental caries and severe periodontitis – a comprehensive review. J Clin Periodontol. 2017;44(Suppl 18):S94–S105.
   PubMedGoogle Scholar
• Martinez-Herrera M, Silvestre-Rangil J, Silvestre FJ. Association between obesity and periodontal disease: a systematic review of epidemiological studies and controlled clinical trials. Med Oral Patol Oral Cir Bucal. 2017;22(6):e708–e715.
   PubMed Web of Science ®Google Scholar
• Merchant AT, Pitiphat W, Rimm EB, et al. Increased physical activity decreases periodontitis risk in men. Eur J Epidemiol. 2003;18(9):891–898.
   PubMed Web of Science ®Google Scholar
• El-Sharkawy HM, Anees MM, Van Dyke TE. Propolis improves periodontal status and glycemic control in patients with type 2 diabetes mellitus and chronic periodontitis: a randomized clinical trial. J Periodontol. 2016;87(12):1418–1426.
   PubMed Web of Science ®Google Scholar
• Estemalik J, Demko C, Bissada NF, et al. Simultaneous detection of oral pathogens in subgingival plaque and prostatic fluid of men with periodontal and prostatic diseases. J Periodontol. 2017;88(9):823–829.
   PubMed Web of Science ®Google Scholar
• Sun J, Huang T, Chen C, et al. Comparison of fecal microbial composition and antibiotic resistance genes from swine, farm workers and the surrounding villagers. Sci Rep. 2017;7(1):4965.
   PubMedGoogle Scholar
• Velsko IM, Fellows Yates JA, Aron F, et al. Microbial differences between dental plaque and historic dental calculus are related to oral biofilm maturation stage. Microbiome. 2019;7(1):102.
   PubMedGoogle Scholar
• Hashim D, Sartori S, La Vecchia C, et al. Hormone factors play a favorable role in female head and neck cancer risk. Cancer Med. 2017;6(8):1998–2007.
   PubMed Web of Science ®Google Scholar
• Saraiya K, Nadig P, Shah M, et al. Dental calculus – an evergrowing heap of periodontal pathogens. J Integr Health Sci. 2019;7(2):73–74.
   Google Scholar
• Caton JG, Armitage G, Berglundh T, et al. A new classification scheme for periodontal and peri-implant diseases and conditions – introduction and key changes from the 1999 classification. J Clin Periodontol. 2018;45(Suppl 20):S1–S8.
   PubMed Web of Science ®Google Scholar
• Armitage GC. Development of a classification system for periodontal diseases and conditions. Northwest Dent. 2000;79(6):31–35.
   PubMedGoogle Scholar
• Erriu M, Genta G, Pili FM, et al. Probing depth in periodontal pockets: in vitro evaluation of contributions to variability due to probe type and operator skill. Proc Inst Mech Eng H. 2015;229(10):743–749.
   PubMed Web of Science ®Google Scholar
• Al Shayeb KN, Turner W, Gillam DG. Periodontal probing: a review. Prim Dent J. 2014;3(3):25–29.
   PubMedGoogle Scholar
• Armitage GC. Manual periodontal probing in supportive periodontal treatment. Periodontol 2000. 1996;12:33–39.
   PubMed Web of Science ®Google Scholar
• Elashiry M, Meghil MM, Arce RM, et al. From manual periodontal probing to digital 3D imaging to endoscopic capillaroscopy: recent advances in periodontal disease diagnosis. J Periodontal Res. 2019;54(1):1–9.
   PubMed Web of Science ®Google Scholar
• Kornman KS, Papapanou PN. Clinical application of the new classification of periodontal diseases: ground rules, clarifications and “gray zones”. J Periodontol. 2020;91(3):352–360.
   PubMed Web of Science ®Google Scholar
• Persson GR, Pettersson T, Ohlsson O, et al. High-sensitivity serum C-reactive protein levels in subjects with or without myocardial infarction or periodontitis. J Clin Periodontol. 2005;32(3):219–224.
   PubMed Web of Science ®Google Scholar
• Escobar GF, Abdalla DR, Beghini M, et al. Levels of pro and anti-inflammatory citokynes and C-reactive protein in patients with chronic periodontitis submitted to nonsurgical periodontal treatment. Asian Pac J Cancer Prev. 2018;19(7):1927–1933.
   PubMedGoogle Scholar
• Redman RS, Kerr GS, Payne JB, et al. Salivary and serum procalcitonin and C-reactive protein as biomarkers of periodontitis in United States veterans with osteoarthritis or rheumatoid arthritis. Biotech Histochem. 2016;91(2):77–85.
   PubMed Web of Science ®Google Scholar
• Podzimek S, Mysak J, Janatova T, et al. C-reactive protein in peripheral blood of patients with chronic and aggressive periodontitis, gingivitis, and gingival recessions. Mediators Inflamm. 2015;2015:564858.
   PubMed Web of Science ®Google Scholar
• Korte DL, Kinney J. Personalized medicine: an update of salivary biomarkers for periodontal diseases. Periodontol 2000. 2016;70(1):26–37.
   PubMed Web of Science ®Google Scholar
• Lahdentausta LSJ, Paju S, Mäntylä P, et al. Saliva and serum biomarkers in periodontitis and coronary artery disease. J Clin Periodontol. 2018;45(9):1045–1055.
   PubMed Web of Science ®Google Scholar
• Nguyen TT, Ngo LQ, Promsudthi A, et al. Salivary oxidative stress biomarkers in chronic periodontitis and acute coronary syndrome. Clin Oral Invest. 2017;21(7):2345–2353.
   PubMed Web of Science ®Google Scholar
• Drabovich AP, Martínez-Morillo E, Diamandis EP. Toward an integrated pipeline for protein biomarker development. Biochim Biophys Acta. 2015;1854(6):677–686.
   PubMed Web of Science ®Google Scholar
• Borrebaeck CA. Precision diagnostics: moving towards protein biomarker signatures of clinical utility in cancer. Nat Rev Cancer. 2017;17(3):199–204.
   PubMed Web of Science ®Google Scholar
• Chung M, York BR, Michaud DS. Oral health and cancer. Curr Oral Health Rep. 2019;6(2):130–137.
   PubMedGoogle Scholar
• Baeza M, Garrido M, Hernández-Ríos P, et al. Diagnostic accuracy for apical and chronic periodontitis biomarkers in gingival crevicular fluid: an exploratory study. J Clin Periodontol. 2016;43(1):34–45.
   PubMed Web of Science ®Google Scholar
• Jaedicke KM, Preshaw PM, Taylor JJ. Salivary cytokines as biomarkers of periodontal diseases. Periodontol 2000. 2016;70(1):164–183.
   PubMed Web of Science ®Google Scholar
• Ghallab NA. Diagnostic potential and future directions of biomarkers in gingival crevicular fluid and saliva of periodontal diseases: review of the current evidence. Arch Oral Biol. 2018;87:115–124.
   PubMed Web of Science ®Google Scholar
• Lahdentausta L, Sorsa T, Pesonen E, et al. The use of serum MMP-9 and TIMP-1 in acute coronary syndrome. J Cardiovasc Transl Res. 2018;11(6):526–527.
   PubMed Web of Science ®Google Scholar
• Wong DT. Salivary diagnostics. Am Sci. 2008;96(1):37–43.
   PubMed Web of Science ®Google Scholar
• Khurshid Z, Asiri FYI, Al Wadaani H. Human saliva: non-invasive fluid for detecting novel coronavirus (2019-nCoV). Int J Environ Res Public Health. 2020;17(7):2225.
   Google Scholar
• Tsai CT, Robinson PV, Cortez FJ, et al. Antibody detection by agglutination-PCR (ADAP) enables early diagnosis of HIV infection by oral fluid analysis. Proc Natl Acad Sci USA. 2018;115(6):1250–1255.
   PubMed Web of Science ®Google Scholar
• Bosqui LR, Gonçalves ALR, Gonçalves-Pires MRF, et al. Immune complex detection in saliva samples: an innovative proposal for the diagnosis of human strongyloidiasis. Parasitology. 2018;145(8):1090–1094.
   PubMed Web of Science ®Google Scholar
• Javaid MA, Ahmed AS, Durand R, et al. Saliva as a diagnostic tool for oral and systemic diseases. J Oral Biol Craniofac Res. 2016;6(1):66–75.
   PubMedGoogle Scholar
• Mfuh KO, Tassi Yunga S, Esemu LF, et al. Detection of Plasmodium falciparum DNA in saliva samples stored at room temperature: potential for a non-invasive saliva-based diagnostic test for malaria. Malar J. 2017;16(1):434.
   PubMedGoogle Scholar
• Milanowski M, Pomastowski P, Ligor T, et al. Saliva – volatile biomarkers and profiles. Crit Rev Anal Chem. 2017;47(3):251–266.
   PubMed Web of Science ®Google Scholar
• Liukkonen J, Gürsoy UK, Könönen E, et al. Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype. Innate Immun. 2018;24(7):439–447.
   PubMed Web of Science ®Google Scholar
• Hasan F, Ikram R, Simjee SU, et al. The effects of aspirin gel and mouthwash on levels of salivary biomarkers PGE2, TNF-α and nitric oxide in patients with periodontal diseases. Pak J Pharm Sci. 2019;32(5):2019–2023.
   PubMed Web of Science ®Google Scholar
• Rangbulla V, Nirola A, Gupta M, et al. Salivary IgA, Interleukin-1β and MMP-8 as salivary biomarkers in chronic periodontitis patients. Chin J Dent Res. 2017;20(1):43–51.
   PubMed Web of Science ®Google Scholar
• Shazam H, Shaikh F, Hussain Z, et al. Evaluation of osteocalcin levels in saliva of periodontitis patients and their correlation with the disease severity: a cross-sectional study. Eur J Dent. 2020;14(03):352–359.
   PubMedGoogle Scholar
• Ochanji AA, Matu NK, Mulli TK. Association of salivary RANKL and osteoprotegerin levels with periodontal health. Clin Exp Dent Res. 2017;3(2):45–50.
   PubMed Web of Science ®Google Scholar
• Jourdain ML, Velard F, Pierrard L, et al. Cationic antimicrobial peptides and periodontal physiopathology: a systematic review. J Periodontal Res. 2019;54(6):589–600.
   PubMed Web of Science ®Google Scholar
• Mallapragada S, Wadhwa A, Agrawal P. Antimicrobial peptides: the miraculous biological molecules. J Indian Soc Periodontol. 2017;21(6):434–438.
   PubMedGoogle Scholar
• Abraham S, Premnath A, Arunima PR, et al. Critical appraisal of bidirectional relationship between periodontitis and hyperlipidemia. J Int Soc Prev Community Dent. 2019;9(2):112–118.
   PubMed Web of Science ®Google Scholar
• Bechinger B, Gorr SU. Antimicrobial peptides: mechanisms of action and resistance. J Dent Res. 2017;96(3):254–260.
   PubMed Web of Science ®Google Scholar
• Tada H, Shimizu T, Matsushita K, et al. Porphyromonas gingivalis-induced IL-33 down-regulates hCAP-18/LL-37 production in human gingival epithelial cells. Biomed Res. 2017;38(3):167–173.
   PubMed Web of Science ®Google Scholar
• Turkoglu O, Emingil G, Eren G, et al. Gingival crevicular fluid and serum hCAP18/LL-37 levels in generalized aggressive periodontitis. Clin Oral Invest. 2017;21(3):763–769.
   PubMed Web of Science ®Google Scholar
• Li S, Zhang Y, Sun Y, et al. Exposure to fermentation supernatant of Staphylococcus aureus accelerated dedifferentiation of chondrocytes and production of antimicrobial peptides. J Orthop Res. 2018;36(1):443–451.
   PubMed Web of Science ®Google Scholar
• Khurshid Z, Zafar MS, Naseem M, et al. Human oral defensins antimicrobial peptides: a future promising antimicrobial drug. Curr Pharm Des. 2018;24(10):1130–1137.
   PubMed Web of Science ®Google Scholar
• Jourdain ML, Pierrard L, Kanagaratnam L, et al. Antimicrobial peptide gene expression in periodontitis patients: a pilot study. J Clin Periodontol. 2018;45(5):524–537.
   PubMed Web of Science ®Google Scholar
• Aidoukovitch A, Dahl S, Fält F, et al. Antimicrobial peptide LL-37 and its pro-form, hCAP18, in desquamated epithelial cells of human whole saliva. Eur J Oral Sci. 2020;128(1):1–6.
   PubMed Web of Science ®Google Scholar
• Heidari E, Andiappan M, Banerjee A, et al. The oral health of individuals with dental phobia: a multivariate analysis of the Adult Dental Health Survey, 2009. Br Dent J. 2017;222(8):595–604.
   PubMed Web of Science ®Google Scholar
• Amerikova M, Pencheva El-Tibi I, Maslarska V, et al. Antimicrobial activity, mechanism of action, and methods for stabilisation of defensins as new therapeutic agents. Biotechnol Biotechnol Equip. 2019;33(1):671–682.
   Web of Science ®Google Scholar
• Sulijaya B, Tadjoedin FM, Kuswandani SO, et al. Existence of human beta defensin-1 peptide on periodontal disease: an updated review based on case-control and cross-sectional studies. Asian J of App Sci. 2017;10(2):50–56.
   Google Scholar
• Yilmaz D, Topcu AO, Akcay EU, et al. Salivary human beta-defensins and cathelicidin levels in relation to periodontitis and type 2 diabetes mellitus. Acta Odontol Scand. 2020;78(5):327–331.
   PubMed Web of Science ®Google Scholar
• Khurshid Z, Zafar MS, Khan RS, et al. Role of salivary biomarkers in oral cancer detection. Adv Clin Chem. 2018;86:23–70.
   PubMed Web of Science ®Google Scholar
• Goeke JE, Kist S, Schubert S, et al. Sensitivity of caries pathogens to antimicrobial peptides related to caries risk. Clin Oral Invest. 2018;22(7):2519–2525.
   PubMed Web of Science ®Google Scholar
• Bastos P, Trindade F, Ferreira R, et al. Unveiling antimicrobial peptide-generating human proteases using PROTEASIX. J Proteomics. 2018;171:53–62.
   PubMed Web of Science ®Google Scholar
• Bastos P, Trindade F, da Costa J, et al. Human antimicrobial peptides in bodily fluids: current knowledge and therapeutic perspectives in the postantibiotic era. Med Res Rev. 2018;38(1):101–146.
   PubMed Web of Science ®Google Scholar
• Thomas B, Prasad BR, Kumari NS, et al. A comparative evaluation of the micronutrient profile in the serum of diabetes mellitus Type II patients and healthy individuals with periodontitis. J Indian Soc Periodontol. 2019;23(1):12–20.
   PubMedGoogle Scholar
• Le CF, Fang CM, Sekaran SD. Intracellular targeting mechanisms by antimicrobial peptides. Antimicrob Agents Chemother. 2017;61(4):e0234016.
   Web of Science ®Google Scholar
• Kanmaz B, Lappin DF, Nile CJ, et al. Effects of smoking on non-surgical periodontal therapy in patients with periodontitis Stage III or IV, and Grade C. J Periodontol. 2020;91(4):442–453.
   PubMed Web of Science ®Google Scholar
• Boyapati R, Chinthalapani S, Ramisetti A, et al. Association of pentraxin and high-sensitive C-reactive protein as inflammatory biomarkers in patients with chronic periodontitis and peripheral arterial disease. J Indian Soc Periodontol. 2018;22(2):112–115.
   PubMedGoogle Scholar
• Nakajima M, Hosojima M, Tabeta K, et al. β2-microglobulin and neutrophil gelatinase-associated lipocalin, potential novel urine biomarkers in periodontitis: a cross-sectional study in Japanese. Int J Dent. 2019;2019:1394678.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Chen B, Zhu D, et al. Biomarker levels in gingival crevicular fluid of subjects with different periodontal conditions: a cross-sectional study. Arch Oral Biol. 2016;72:92–98.
   PubMed Web of Science ®Google Scholar
• Alfakry H, Malle E, Koyani CN, et al. Neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease. Innate Immun. 2016;22(1):85–99.
   PubMed Web of Science ®Google Scholar
• Patel RM, Varma S, Suragimath G, et al. Estimation and comparison of salivary calcium, phosphorous, alkaline phosphatase and ph levels in periodontal health and disease: a cross-sectional biochemical study. J Clin Diagn Res. 2016;10(7):58–61.
   Web of Science ®Google Scholar
• Kadhim S, Al-Windy S, Al-Kuraishy H, et al. Endothelin-1 is a surrogate biomarker link severe periodontitis and endothelial dysfunction in hypertensive patients: the potential nexus. J Int Oral Health. 2019;11(6):369–375.
   Google Scholar
• Patel A. Management of peri-implant diseases. Dent Today. 2016;35(10):136–139.
   PubMedGoogle Scholar
• Taylor JJ. Protein biomarkers of periodontitis in saliva. ISRN Inflamm. 2014;2014:593151.
   PubMedGoogle Scholar
• Buduneli N. Hyperglycemia and periodontitis: possible mechanisms of interaction. Oral Dis. 2019;25(4):925–927.
   PubMed Web of Science ®Google Scholar
• Davis IJ, Jones AW, Creese AJ, et al. Longitudinal quantification of the gingival crevicular fluid proteome during progression from gingivitis to periodontitis in a canine model. J Clin Periodontol. 2016;43(7):584–594.
   PubMed Web of Science ®Google Scholar
• Bostanci N, Selevsek N, Wolski W, et al. Targeted proteomics guided by label-free quantitative proteome analysis in saliva reveal transition signatures from health to periodontal disease. Mol Cell Proteomics. 2018;17(7):1392–1409.
   PubMed Web of Science ®Google Scholar
• Shin MS, Kim YG, Shin YJ, et al. Deep sequencing salivary proteins for periodontitis using proteomics. Clin Oral Invest. 2019;23(9):3571–3580.
   PubMed Web of Science ®Google Scholar
• Guzman YA, Sakellari D, Papadimitriou K, et al. High-throughput proteomic analysis of candidate biomarker changes in gingival crevicular fluid after treatment of chronic periodontitis. J Periodont Res. 2018;53(5):853–860.
   PubMed Web of Science ®Google Scholar
• Tsuchida S, Satoh M, Takiwaki M, et al. Ubiquitination in periodontal disease: a review. Int J Mol Sci. 2017;18(7):1476.ijms.
   Web of Science ®Google Scholar
• Zeidán-Chuliá F, Gürsoy M, Neves de Oliveira BH, et al. A systems biology approach to reveal putative host-derived biomarkers of periodontitis by network topology characterization of MMP-REDOX/NO and apoptosis integrated pathways. Front Cell Infect Microbiol. 2015;5:102.
   PubMed Web of Science ®Google Scholar
• Wu Y, Shu R, Luo LJ, et al. Initial comparison of proteomic profiles of whole unstimulated saliva obtained from generalized aggressive periodontitis patients and healthy control subjects. J Periodontal Res. 2009;44(5):636–644.
   PubMed Web of Science ®Google Scholar
• Khudhur AS. Identification and characterization of novel salivary biomarkers for oral inflammatory disease [PhD thesis]. Newcastle (UK): Newcastle University; 2017. Available from: https://core.ac.uk/download/pdf/188733563.pdf
   Google Scholar
• Zhang X, Meng H, Xu L, et al. Vitamin D-binding protein levels in plasma and gingival crevicular fluid of patients with generalized aggressive periodontitis. Int J Endocrinol. 2014;2014:1–6.
   Web of Science ®Google Scholar
• Salazar MG, Jehmlich N, Murr A, et al. Identification of periodontitis associated changes in the proteome of whole human saliva by mass spectrometric analysis. J Clin Periodontol. 2013;40(9):825–832.
   PubMed Web of Science ®Google Scholar
• Katsani KR, Sakellari D. Saliva proteomics updates in biomedicine. J Biol Res. 2019;26:17.
   Web of Science ®Google Scholar
• Shah S. Salivaomics: the current scenario. J Oral Maxillofac Pathol. 2018;22(3):375–381.
   PubMedGoogle Scholar
• Aro K, Kaczor-Urbanowicz K, Carreras-Presas CM. Salivaomics in oral cancer. Curr Opin Otolaryngol Head Neck Surg. 2019;27(2):91–97.
   PubMed Web of Science ®Google Scholar
• Khurshid Z, Warsi I, Moin SF, et al. Biochemical analysis of oral fluids for disease detection. Adv Clin Chem. 2021;100:205–253.
   PubMed Web of Science ®Google Scholar
• Wang E, Cho WCS, Wong SCC, et al. Disease biomarkers for precision medicine: challenges and future opportunities. Genom Proteom Bioinf. 2017;15(2):57–58.
   PubMed Web of Science ®Google Scholar
• Bellagambi FG, Lomonaco T, Salvo P, et al. Saliva sampling: methods and devices. An overview. Trends Analyt Chem. 2020;124(6):115781.
   Google Scholar
• Khurshid Z, Mali M, Naseem M, et al. Human gingival crevicular fluids (GCF) proteomics: an overview. Dent J. 2017;5(1):12.
   Google Scholar
• Bonebreak CM, Demirci U, Kuo WP. The potential of salivary point of care diagnostics. J Appl Oral Sci. 2011;19(4):1.
   PubMedGoogle Scholar
• Vincent JL, Bogossian E, Menozzi M. The future of biomarkers. Crit Care Clin. 2020;36(1):177–187.
   PubMed Web of Science ®Google Scholar
• Giannobile WV, Beikler T, Kinney JS, et al. Saliva as a diagnostic tool for periodontal disease: current state and future directions. Periodontol 2000. 2009;50:52–64.
   PubMed Web of Science ®Google Scholar
• Malon RSP, Sadir S, Balakrishnan M, et al. Saliva-based biosensors: noninvasive monitoring tool for clinical diagnostics. Biomed Res Int. 2014;2014:962903.
   PubMed Web of Science ®Google Scholar
• Punyadeera C, Slowey PD. Saliva as an emerging biofluid for clinical diagnosis and applications of MEMS/NEMS in salivary diagnostics. In: Subramani K, Ahmed W, editors. Nanobiomaterials in clinical dentistry. 2nd ed. Amsterdam: Elsevier Netherlands; 2019. p. 543–565.
   Google Scholar
• Luong JHT, Vashist SK. Chemistry of biotin-streptavidin and the growing concern of an emerging biotin interference in clinical immunoassays. ACS Omega. 2020;5(1):10–18.
   PubMed Web of Science ®Google Scholar
• Wei X, Zhao HQ, Ma C, et al. The association between chronic periodontitis and oral Helicobacter pylori: a meta-analysis. PLoS One. 2019;14(12):e0225247.
   PubMed Web of Science ®Google Scholar
• Taylor JJ, Jaedicke KM, van de Merwe RC, et al. A prototype antibody-based biosensor for measurement of salivary MMP-8 in periodontitis using surface acoustic wave technology. Sci Rep. 2019;9(1):11034.
   PubMedGoogle Scholar
• Yee EH, Lathwal S, Shah PP, et al. Detection of biomarkers of periodontal disease in human saliva using stabilized, vertical flow immunoassays. ACS Sens. 2017;2(11):1589–1593.
   PubMed Web of Science ®Google Scholar
• Piau A, Wild K, Mattek N, et al. Current state of digital biomarker technologies for real-life, home-based monitoring of cognitive function for mild cognitive impairment to mild Alzheimer disease and implications for clinical care: systematic review. J Med Internet Res. 2019;21(8):e12785.
   PubMed Web of Science ®Google Scholar
• Coravos A, Khozin S, Mandl KD. Developing and adopting safe and effective digital biomarkers to improve patient outcomes. NPJ Digit Med. 2019;2(1):14.
   PubMedGoogle Scholar
• Hernandez-Rios P, Hernandez M, Garrido M, et al. Oral fluid matrix metalloproteinase (MMP)-8 as a diagnostic tool in chronic periodontitis. Metalloproteinases in Med. 2016;3:11–18.
   Google Scholar