Establishing optimal cutoff values for high-sensitivity cardiac troponin algorithms in risk stratification of acute myocardial infarction

References

• Blomkalns AL, Gibler WB. Chest pain unit concept: rationale and diagnostic strategies. Cardiol Clin. 2005;23(4):411–421. doi: 10.1016/j.ccl.2005.08.011.
   PubMed Web of Science ®Google Scholar
• Niska R, Bhuiya F, Xu J. National hospital ambulatory medical care survey: 2007 emergency department summary. Natl Health Stat Report. 2010;6(26):1–31.
   Google Scholar
• Haasenritter J, Stanze D, Widera G, et al. Does the patient with chest pain have a coronary heart disease? Diagnostic value of single symptoms and signs–a meta-analysis. Croat Med J. 2012;53(5):432–441. doi: 10.3325/cmj.2012.53.432.
   PubMed Web of Science ®Google Scholar
• Apple FS, Collinson PO. Analytical characteristics of high-sensitivity cardiac troponin assays. Clin Chem. 2012;58(1):54–61. doi: 10.1373/clinchem.2011.165795.
   PubMed Web of Science ®Google Scholar
• Kavsak PA, MacRae AR, Yerna MJ, et al. Analytic and clinical utility of a next-generation, highly sensitive cardiac troponin I assay for early detection of myocardial injury. Clin Chem. 2009;55(3):573–577. doi: 10.1373/clinchem.2008.116020.
   PubMed Web of Science ®Google Scholar
• Wu AHB, Christenson RH, Greene DN, et al. Clinical laboratory practice recommendations for the use of cardiac troponin in acute coronary syndrome: expert opinion from the academy of the American Association for Clinical Chemistry and the task force on clinical applications of cardiac bio-markers of the international federation of clinical chemistry and laboratory medicine. Clin Chem. 2018;64(4):645–655. doi: 10.1373/clinchem.2017.277186.
   PubMed Web of Science ®Google Scholar
• Eggers KM, Lind L, Venge P, et al. Will the universal definition of myocardial infarction criteria result in an overdiagnosis of myocardial infarction? Am J Cardiol. 2009;103(5):588–591. doi: 10.1016/j.amjcard.2008.11.007.
   PubMed Web of Science ®Google Scholar
• Lippi G, Montagnana M, Guidi GC. The clinical dilemma of positive results of high-sensitive troponin assays. Am J Cardiol. 2009;103(9):1332. doi: 10.1016/j.amjcard.2009.02.037.
   PubMed Web of Science ®Google Scholar
• Reichlin T, Hochholzer W, Bassetti S, et al. Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med. 2009;361(9):858–867. doi: 10.1056/NEJMoa0900428.
   PubMed Web of Science ®Google Scholar
• Christ M, Popp S, Pohlmann H, et al. Implementation of high sensitivity cardiac troponin T measurement in the emergency department. Am J Med. 2010;123(12):1134–1142. doi: 10.1016/j.amjmed.2010.07.015.
   PubMed Web of Science ®Google Scholar
• Latini R, Masson S, Anand IS, et al. Prognostic value of very low plasma concentrations of troponin T in patients with stable chronic heart failure. Circulation. 2007;116(11):1242–1249. doi: 10.1161/CIRCULATIONAHA.106.655076.
   PubMed Web of Science ®Google Scholar
• Vickers AJ, Lilja H. Cutpoints in clinical chemistry: time for fundamental reassessment. Clin Chem. 2009;55(1):15–17. doi: 10.1373/clinchem.2008.114694.
   PubMed Web of Science ®Google Scholar
• Alpert JS, Thygesen K, Antman E, et al. Myocardial infarction redefined–a consensus document of the joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 2000;36(3):959–969. doi: 10.1016/s0735-1097(00)00804-4.
   PubMed Web of Science ®Google Scholar
• Apple FS, Jaffe AS, Collinson P, et al. IFCC educational materials on selected analytical and clinical applications of high sensitivity cardiac troponin assays. Clin Biochem. 2015;48(4–5):201–203. doi: 10.1016/j.clinbiochem.2014.08.021.
   PubMed Web of Science ®Google Scholar
• Morrow DA, Cannon CP, Jesse RL, et al. National Academy of Clinical Biochemistry laboratory medicine practice guidelines: clinical characteristics and utilization of biochemical markers in acute coronary syndromes. Clin Chem. 2007;53(4):552–574. doi: 10.1373/clinchem.2006.084194.
   PubMed Web of Science ®Google Scholar
• Bertrand ME, Simoons ML, Fox KA, et al. Management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 2002;23(23):1809–1840. doi: 10.1053/euhj.2002.3385.
   PubMed Web of Science ®Google Scholar
• Braunwald E, Antman EM, Beasley JW, et al. ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction. A report of the American college of cardiology/American heart association task force on practice guidelines (committee on the management of patients with unstable angina). J Am Coll Cardiol. 2000;36(3):970–1062. doi: 10.1016/s0735-1097(00)00889-5.
   PubMed Web of Science ®Google Scholar
• Aldous SJ, Florkowski CM, Crozier IG, et al. Comparison of high sensitivity and contemporary troponin assays for the early detection of acute myocardial infarction in the emergency department. Ann Clin Biochem. 2011;48(Pt 3):241–248. doi: 10.1258/acb.2010.010219.
   PubMedGoogle Scholar
• Aldous SJ, Richards AM, Cullen L, et al. Early dynamic change in high-sensitivity cardiac troponin T in the investigation of acute myocardial infarction. Clin Chem. 2011;57(8):1154–1160. doi: 10.1373/clinchem.2010.161166.
   PubMed Web of Science ®Google Scholar
• Hammerer-Lercher A, Ploner T, Neururer S, et al. High-sensitivity cardiac troponin T compared with standard troponin T testing on emergency department admission: how much does it add in everyday clinical practice? J Am Heart Assoc. 2013;2(3):e000204. doi: 10.1161/JAHA.113.000204.
   PubMed Web of Science ®Google Scholar
• Melki D, Lind S, Agewall S, et al. Diagnostic value of high sensitive troponin T in chest pain patients with no persistent ST-elevations. Scand Cardiovasc J. 2011;45(4):198–204. doi: 10.3109/14017431.2011.565792.
   PubMed Web of Science ®Google Scholar
• Santaló M, Martin A, Velilla J, et al. Using high-sensitivity troponin T: the importance of the proper gold standard. Am J Med. 2013;126(8):709–717. doi: 10.1016/j.amjmed.2013.03.003.
   PubMed Web of Science ®Google Scholar
• Giannitsis E, Becker M, Kurz K, et al. High-sensitivity cardiac troponin T for early prediction of evolving non-ST-segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admission. Clin Chem. 2010;56(4):642–650. doi: 10.1373/clinchem.2009.134460.
   PubMed Web of Science ®Google Scholar
• Aldous SJ, Richards M, Cullen L, et al. Diagnostic and prognostic utility of early measurement with high-sensitivity troponin T assay in patients presenting with chest pain. CMAJ. 2012;184(5):E260–8. doi: 10.1503/cmaj.110773.
   PubMed Web of Science ®Google Scholar
• Keller T, Zeller T, Ojeda F, et al. Serial changes in highly sensitive troponin I assay and early diagnosis of myocardial infarction. JAMA. 2011;306(24):2684–2693. doi: 10.1001/jama.2011.1896.
   PubMed Web of Science ®Google Scholar
• Zhelev Z, Hyde C, Youngman E, et al. Diagnostic accuracy of single baseline measurement of elecsys troponin T high-sensitive assay for diagnosis of acute myocardial infarction in emergency department: systematic review and meta-analysis. BMJ. 2015;350:h15. doi: 10.1136/bmj.h15.
   PubMed Web of Science ®Google Scholar
• Pickering JW, Than MP, Cullen L, et al. Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin T measurement below the limit of detection: a collaborative meta-analysis. Ann Intern Med. 2017;166(10):715–724. doi: 10.7326/M16-2562.
   PubMed Web of Science ®Google Scholar
• Chapman AR, Sandeman D, Ferry AV, et al. Risk stratification using high-sensitivity cardiac troponin T in patients with suspected acute coronary syndrome. J Am Coll Cardiol. 2020;75(8):985–987. doi: 10.1016/j.jacc.2019.12.036.
   PubMed Web of Science ®Google Scholar
• Carlton EW, Ingram J, Taylor H, et al. Limit of detection of troponin discharge strategy versus usual care: randomised controlled trial. Heart. 2020;106(20):1586–1594. doi: 10.1136/heartjnl-2020-316692.
   PubMed Web of Science ®Google Scholar
• Chew DP, Lambrakis K, Blyth A, et al. A randomized trial of a 1-hour troponin T protocol in suspected acute coronary syndromes: the rapid assessment of possible acute coronary syndrome in the emergency department with high-sensitivity troponin T study (RAPID-TnT). Circulation. 2019;140(19):1543–1556. doi: 10.1161/CIRCULATIONAHA.119.042891.
   PubMed Web of Science ®Google Scholar
• Shah AS, Anand A, Sandoval Y, et al. High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study. Lancet. 2015;386(10012):2481–2488. doi: 10.1016/S0140-6736(15)00391-8.
   PubMed Web of Science ®Google Scholar
• Chapman AR, Lee KK, McAllister DA, et al. Association of high-sensitivity cardiac troponin I concentration with cardiac outcomes in patients with suspected acute coronary syndrome. JAMA. 2017;318(19):1913–1924. doi: 10.1001/jama.2017.17488.
   PubMed Web of Science ®Google Scholar
• Anand A, Lee KK, Chapman AR, et al. High-sensitivity cardiac troponin on presentation to rule out myocardial infarction: a stepped-wedge cluster randomized controlled trial. Circulation. 2021;143(23):2214–2224. doi: 10.1161/CIRCULATIONAHA.120.052380.
   PubMed Web of Science ®Google Scholar
• Neumann JT, Sörensen NA, Schwemer T, et al. Diagnosis of myocardial infarction using a high-sensitivity troponin I 1-hour algorithm. JAMA Cardiol. 2016;1(4):397–404. doi: 10.1001/jamacardio.2016.0695.
   PubMed Web of Science ®Google Scholar
• Chapman AR, Stewart S, Mills NL. Novel high-sensitivity cardiac troponin I assay in patients with suspected acute coronary syndrome. Heart. 2019;105(10):740–741. doi: 10.1136/heartjnl-2018-314306.
   PubMed Web of Science ®Google Scholar
• Sandoval Y, Nowak R, deFilippi CR, et al. Myocardial infarction risk stratification with a single measurement of high-sensitivity troponin I. J Am Coll Cardiol. 2019;74(3):271–282. doi: 10.1016/j.jacc.2019.05.058.
   PubMed Web of Science ®Google Scholar
• Sandoval Y, Smith SW, Love SA, et al. Single high-sensitivity cardiac troponin I to rule out acute myocardial infarction. Am J Med. 2017;130(9):1076–1083.e1. doi: 10.1016/j.amjmed.2017.02.032.
   PubMed Web of Science ®Google Scholar
• Greenslade J, Cho E, Van Hise C, et al. Evaluating rapid rule-out of acute myocardial infarction using a high-sensitivity cardiac troponin I assay at presentation. Clin Chem. 2018;64(5):820–829. doi: 10.1373/clinchem.2017.283887.
   PubMed Web of Science ®Google Scholar
• Harris EK. Effects of intra- and interindividual variation on the appropriate use of normal ranges. Clin Chem. 1974;20(12):1535–1542. doi: 10.1093/clinchem/20.12.1535.
   PubMed Web of Science ®Google Scholar
• Vasile VC, Saenger AK, Kroning JM, et al. Biological and analytical variability of a novel high-sensitivity cardiac troponin T assay. Clin Chem. 2010;56(7):1086–1090. doi: 10.1373/clinchem.2009.140616.
   PubMed Web of Science ®Google Scholar
• Aakre KM, Røraas T, Petersen PH, et al. Weekly and 90-minute biological variations in cardiac troponin T and cardiac troponin I in hemodialysis patients and healthy controls. Clin Chem. 2014;60(6):838–847. doi: 10.1373/clinchem.2013.216978.
   PubMed Web of Science ®Google Scholar
• Nordenskjöld AM, Ahlström H, Eggers KM, et al. Short- and long-term individual variation in cardiac troponin in patients with stable coronary artery disease. Clin Chem. 2013;59(2):401–409. doi: 10.1373/clinchem.2012.191700.
   PubMed Web of Science ®Google Scholar
• Wu AH, Lu QA, Todd J, et al. Short- and long-term biological variation in cardiac troponin I measured with a high-sensitivity assay: implications for clinical practice. Clin Chem. 2009;55(1):52–58. doi: 10.1373/clinchem.2008.107391.
   PubMed Web of Science ®Google Scholar
• van der Linden N, Hilderink JM, Cornelis T, et al. Twenty-four-hour biological variation profiles of cardiac troponin I in individuals with or without chronic kidney disease. Clin Chem. 2017;63(10):1655–1656. doi: 10.1373/clinchem.2017.275107.
   PubMed Web of Science ®Google Scholar
• Simpson AJ, Potter JM, Koerbin G, et al. Use of observed within-person variation of cardiac troponin in emergency department patients for determination of biological variation and percentage and absolute reference change values. Clin Chem. 2014;60(6):848–854. doi: 10.1373/clinchem.2013.219410.
   PubMed Web of Science ®Google Scholar
• Goldberg J, Iriarte B, Prostko J, et al. Short and long-term biological variability of troponin I determined using the ARCHITECT STAT high sensitive troponin I assay. Clin Chem. 2011;57: A97.
   Google Scholar
• Apple F, Murakami M, Wians F, et al. Short-term biological variation of cardiac troponin I measured with three high-sensitivity assays. Clin Chem. 2011;57:C05.
   Google Scholar
• Lan NSR, Nguyen LT, Vasikaran SD, et al. Short- and long-term biological variation of cardiac troponin I in healthy individuals, and patients with end-stage renal failure requiring haemodialysis or cardiomyopathy. Clin Chem Lab Med. 2020;58(11):1941–1949. doi: 10.1515/cclm-2020-0046.
   PubMed Web of Science ®Google Scholar
• Zaninotto M, Padoan A, Mion MM, et al. Short-term biological variation and diurnal rhythm of cardiac troponin I (access hs-TnI) in healthy subjects. Clin Chim Acta. 2020;504:163–167. doi: 10.1016/j.cca.2020.02.004.
   PubMed Web of Science ®Google Scholar
• Reichlin T, Irfan A, Twerenbold R, et al. Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction. Circulation. 2011;124(2):136–145. doi: 10.1161/CIRCULATIONAHA.111.023937.
   PubMed Web of Science ®Google Scholar
• Liu L, Consagra W, Cai X, et al. Sex-specific absolute Delta thresholds for high-sensitivity cardiac troponin T. Clin Chem. 2022;68(3):441–449. doi: 10.1093/clinchem/hvab230.
   PubMed Web of Science ®Google Scholar
• Shah ASV, Sandoval Y, Noaman A, et al. Patient selection for high sensitivity cardiac troponin testing and diagnosis of myocardial infarction: prospective cohort study. BMJ. 2017;359:j4788. doi: 10.1136/bmj.j4788.
   PubMed Web of Science ®Google Scholar
• Lee KK, Noaman A, Vaswani A, et al. Prevalence, determinants, and clinical associations of high-sensitivity cardiac troponin in patients attending emergency departments. Am J Med. 2019;132(1):110.e8–110.e21. doi: 10.1016/j.amjmed.2018.10.002.
   PubMed Web of Science ®Google Scholar
• Newby LK, Jesse RL, Babb JD, et al. ACCF 2012 expert consensus document on practical clinical considerations in the interpretation of troponin elevations: a report of the American college of cardiology foundation task force on clinical expert consensus documents. J Am Coll Cardiol. 2012;60(23):2427–2463. doi: 10.1016/j.jacc.2012.08.969.
   PubMed Web of Science ®Google Scholar
• Shah AS, McAllister DA, Mills R, et al. Sensitive troponin assay and the classification of myocardial infarction. Am J Med. 2015;128(5):493–501.e3. doi: 10.1016/j.amjmed.2014.10.056.
   PubMed Web of Science ®Google Scholar
• Chapman AR, Shah ASV, Lee KK, et al. Long-term outcomes in patients with type 2 myocardial infarction and myocardial injury. Circulation. 2018;137(12):1236–1245. doi: 10.1161/CIRCULATIONAHA.117.031806.
   PubMed Web of Science ®Google Scholar
• Akobeng AK. Understanding diagnostic tests 3: receiver operating characteristic curves. Acta Paediatr. 2007;96(5):644–647. doi: 10.1111/j.1651-2227.2006.00178.x.
   PubMed Web of Science ®Google Scholar
• Perkins NJ, Schisterman EF. The inconsistency of “optimal” cutpoints obtained using two criteria based on the receiver operating characteristic curve. Am J Epidemiol. 2006;163(7):670–675. doi: 10.1093/aje/kwj063.
   PubMed Web of Science ®Google Scholar
• Habibzadeh F, Habibzadeh P, Yadollahie M. On determining the most appropriate test cut-off value: the case of tests with continuous results. Biochem Med. 2016;26(3):297–307. doi: 10.11613/BM.2016.034.
   PubMed Web of Science ®Google Scholar
• Ray P, Le Manach Y, Riou B, et al. Statistical evaluation of a biomarker. Anesthesiology. 2010;112(4):1023–1040. doi: 10.1097/ALN.0b013e3181d47604.
   PubMed Web of Science ®Google Scholar
• Hastie T, Tibshirani R, Friedman JH. Chapter 9: additive models, trees, and related methods. In: Hastie T, Tibshirani R, Friedman JH, eds. The elements of statistical learning. Data mining, inference, and prediction. 2nd ed. New York (NY): Springer; 2009: pp. 305–317.
   Google Scholar
• Hayes T, Usami S, Jacobucci R, et al. Using classification and regression trees (CART) and random forests to analyze attrition: results from two simulations. Psychol Aging. 2015;30(4):911–929. doi: 10.1037/pag0000046.
   PubMed Web of Science ®Google Scholar
• Dalton BR, Krishnan A, Stewart JJ, et al. Limitations of classification and regression tree analysis in vancomycin exposure-response relationship studies: insights from data simulation. Clin Microbiol Infect. 2021;27(11):1701–1703. doi: 10.1016/j.cmi.2021.07.028.
   PubMed Web of Science ®Google Scholar
• Boehmke B, Greenwell B. Chapter 9: decision trees and chapter 10: bagging. In: Boehmke B, Greenwell B, eds. Hands-on machine learning with R. New York (NY): Chapman and Hall/CRC; 2019: pp. 175–200.
   Google Scholar
• Roffi M, Patrono C, Collet JP, et al. 2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: task force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2016;37(3):267–315. doi: 10.1093/eurheartj/ehv320.
   PubMed Web of Science ®Google Scholar
• Hamm CW, Bassand JP, Agewall S, et al. ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: the task force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2011;32(23):2999–3054. doi: 10.1093/eurheartj/ehr236.
   PubMed Web of Science ®Google Scholar
• Thygesen K, Mair J, Giannitsis E, et al. How to use high-sensitivity cardiac troponins in acute cardiac care. Eur Heart J. 2012;33(18):2252–2257. doi: 10.1093/eurheartj/ehs154.
   PubMed Web of Science ®Google Scholar
• Thygesen K, Alpert JS, White HD. Universal definition of myocardial infarction. Eur Heart J. 2007;28(20):2525–2538. doi: 10.1093/eurheartj/ehm355.
   PubMed Web of Science ®Google Scholar
• Wu AH, Jaffe AS, Apple FS, et al. National Academy of Clinical Biochemistry laboratory medicine practice guidelines: use of cardiac troponin and B-type natriuretic peptide or N-terminal proB-type natriuretic peptide for etiologies other than acute coronary syndromes and heart failure. Clin Chem. 2007;53(12):2086–2096. doi: 10.1373/clinchem.2007.095679.
   PubMed Web of Science ®Google Scholar
• Pickering JW, Greenslade JH, Cullen L, et al. Validation of presentation and 3 h high-sensitivity troponin to rule-in and rule-out acute myocardial infarction. Heart. 2016;102(16):1270–1278. doi: 10.1136/heartjnl-2015-308505.
   PubMed Web of Science ®Google Scholar
• Chapman AR, Anand A, Boeddinghaus J, et al. Comparison of the efficacy and safety of early rule-out pathways for acute myocardial infarction. Circulation. 2017;135(17):1586–1596. doi: 10.1161/CIRCULATIONAHA.116.025021.
   PubMed Web of Science ®Google Scholar
• Mueller M, Biener M, Vafaie M, et al. Absolute and relative kinetic changes of high-sensitivity cardiac troponin T in acute coronary syndrome and in patients with increased troponin in the absence of acute coronary syndrome. Clin Chem. 2012;58(1):209–218. doi: 10.1373/clinchem.2011.171827.
   PubMed Web of Science ®Google Scholar
• Kavsak PA, MacRae AR. Letter by Kavsak and MacRae regarding article, utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction. Circulation. 2012;125(6):e358. doi: 10.1161/CIRCULATIONAHA.111.057885.
   PubMed Web of Science ®Google Scholar
• Kavsak PA, Ko DT, Wang X, et al. Increasing cardiac troponin changes measured by a research high-sensitivity troponin I assay: absolute vs percentage changes and long-term outcomes in a chest pain cohort. Clin Chem. 2010;56(12):1902–1904. doi: 10.1373/clinchem.2010.153486.
   PubMed Web of Science ®Google Scholar
• Irfan A, Reichlin T, Twerenbold R, et al. Early diagnosis of myocardial infarction using absolute and relative changes in cardiac troponin concentrations. Am J Med. 2013;126(9):781.e2–788.e2. doi: 10.1016/j.amjmed.2013.02.031.
   Web of Science ®Google Scholar
• Simpson P, Tirimacco R, Cowley P, et al. A comparison of cardiac troponin T delta change methods and the importance of the clinical context in the assessment of acute coronary syndrome. Ann Clin Biochem. 2019;56(6):701–707. doi: 10.1177/0004563219876671.
   PubMed Web of Science ®Google Scholar
• Haaf P, Drexler B, Reichlin T, et al. High-sensitivity cardiac troponin in the distinction of acute myocardial infarction from acute cardiac noncoronary artery disease. Circulation. 2012;126(1):31–40. doi: 10.1161/CIRCULATIONAHA.112.100867.
   PubMed Web of Science ®Google Scholar
• Kim JW, Kim H, Yun Y-M, et al. Absolute change in high-sensitivity cardiac troponin I at three hours after presentation is useful for diagnosing acute myocardial infarction in the emergency department. Ann Lab Med. 2020;40(6):474–480. doi: 10.3343/alm.2020.40.6.474.
   PubMed Web of Science ®Google Scholar
• Ravanavena A, Ravindra C, Igweonu-Nwakile EO, et al. Absolute versus relative changes in cardiac troponins in the diagnosis of myocardial infarction: a systematic review and meta-analysis. Cureus. 2022;14(7):e27414. doi: 10.7759/cureus.27414.
   PubMed Web of Science ®Google Scholar
• Stoyanov KM, Hund H, Biener M, et al. RAPID-CPU: a prospective study on implementation of the ESC 0/1-hour algorithm and safety of discharge after rule-out of myocardial infarction. Eur Heart J Acute Cardiovasc Care. 2020;9(1):39–51. doi: 10.1177/2048872619861911.
   PubMed Web of Science ®Google Scholar
• Haller PM, Boeddinghaus J, Neumann JT, et al. Performance of the ESC 0/1-h and 0/3-h algorithm for the rapid identification of myocardial infarction without ST-elevation in patients with diabetes. Diabetes Care. 2020;43(2):460–467. doi: 10.2337/dc19-1327.
   PubMed Web of Science ®Google Scholar
• Badertscher P, Boeddinghaus J, Twerenbold R, et al. Direct comparison of the 0/1h and 0/3h algorithms for early rule-out of acute myocardial infarction. Circulation. 2018;137(23):2536–2538. doi: 10.1161/CIRCULATIONAHA.118.034260.
   PubMed Web of Science ®Google Scholar
• Reichlin T, Schindler C, Drexler B, et al. One-hour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T. Arch Intern Med. 2012;172(16):1211–1218. doi: 10.1001/archinternmed.2012.3698.
   PubMedGoogle Scholar
• Reichlin T, Twerenbold R, Wildi K, et al. Prospective validation of a 1-hour algorithm to rule-out and rule-in acute myocardial infarction using a high-sensitivity cardiac troponin T assay. CMAJ. 2015;187(8):E243–E252. doi: 10.1503/cmaj.141349.
   PubMed Web of Science ®Google Scholar
• Mueller C, Giannitsis E, Christ M, et al. Multicenter evaluation of a 0-hour/1-hour algorithm in the diagnosis of myocardial infarction with high-sensitivity cardiac troponin T. Ann Emerg Med. 2016;68(1):76.e4–87.e4. doi: 10.1016/j.annemergmed.2015.11.013.
   Web of Science ®Google Scholar
• Twerenbold R, Neumann JT, Sörensen NA, et al. Prospective validation of the 0/1-h algorithm for early diagnosis of myocardial infarction. J Am Coll Cardiol. 2018;72(6):620–632. doi: 10.1016/j.jacc.2018.05.040.
   PubMed Web of Science ®Google Scholar
• Lambrakis K, Papendick C, French JK, et al. Late outcomes of the RAPID-TnT randomized controlled trial: 0/1-hour high-sensitivity troponin T protocol in suspected ACS. Circulation. 2021;144(2):113–125. doi: 10.1161/CIRCULATIONAHA.121.055009.
   PubMed Web of Science ®Google Scholar
• Reichlin T, Cullen L, Parsonage WA, et al. Two-hour algorithm for triage toward rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T. Am J Med. 2015;128(4):369–379.e4. doi: 10.1016/j.amjmed.2014.10.032.
   PubMed Web of Science ®Google Scholar
• Rubini Gimenez M, Twerenbold R, Jaeger C, et al. One-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I. Am J Med. 2015;128(8):861.e4–870.e4. doi: 10.1016/j.amjmed.2015.01.046.
   Web of Science ®Google Scholar
• Boeddinghaus J, Twerenbold R, Nestelberger T, et al. Clinical validation of a novel high-sensitivity cardiac troponin I assay for early diagnosis of acute myocardial infarction. Clin Chem. 2018;64(9):1347–1360. doi: 10.1373/clinchem.2018.286906.
   PubMed Web of Science ®Google Scholar
• Jaeger C, Wildi K, Twerenbold R, et al. One-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I. Am Heart J. 2016;171(1):92–102. doi: 10.1016/j.ahj.2015.07.022.
   PubMed Web of Science ®Google Scholar
• Boeddinghaus J, Nestelberger T, Twerenbold R, et al. High-sensitivity cardiac troponin I assay for early diagnosis of acute myocardial infarction. Clin Chem. 2019;65(7):893–904. doi: 10.1373/clinchem.2018.300061.
   PubMed Web of Science ®Google Scholar
• Boeddinghaus J, Twerenbold R, Nestelberger T, et al. Clinical use of a new high-sensitivity cardiac troponin I assay in patients with suspected myocardial infarction. Clin Chem. 2019;65(11):1426–1436. doi: 10.1373/clinchem.2019.304725.
   PubMed Web of Science ®Google Scholar
• Boeddinghaus J, Nestelberger T, Koechlin L, et al. Early diagnosis of myocardial infarction with point-of-care high-sensitivity cardiac troponin I. J Am Coll Cardiol. 2020;75(10):1111–1124. doi: 10.1016/j.jacc.2019.12.065.
   PubMed Web of Science ®Google Scholar
• Neumann JT, Sörensen NA, Rübsamen N, et al. Evaluation of a new ultra-sensitivity troponin I assay in patients with suspected myocardial infarction. Int J Cardiol. 2019;283:35–40. doi: 10.1016/j.ijcard.2018.12.001.
   PubMed Web of Science ®Google Scholar
• Sörensen NA, Neumann JT, Ojeda F, et al. Diagnostic evaluation of a high-sensitivity troponin I point-of-care assay. Clin Chem. 2019;65(12):1592–1601. doi: 10.1373/clinchem.2019.307405.
   PubMed Web of Science ®Google Scholar
• Collet JP, Thiele H, Barbato E, et al. 2020 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 2021;42(14):1289–1367. doi: 10.1093/eurheartj/ehaa575.
   PubMed Web of Science ®Google Scholar
• Neumann JT, Twerenbold R, Ojeda F, et al. Application of High-Sensitivity troponin in suspected myocardial infarction. N Engl J Med. 2019;380(26):2529–2540. doi: 10.1056/NEJMoa1803377.
   PubMed Web of Science ®Google Scholar
• Khan E, Lambrakis K, Blyth A, et al. Classification performance of clinical risk scoring in suspected acute coronary syndrome beyond a rule-out troponin profile. Eur Heart J Acute Cardiovasc Care. 2021;10(9):1038–1047. doi: 10.1093/ehjacc/zuab040.
   PubMed Web of Science ®Google Scholar
• Ljung L, Lindahl B, Eggers KM, et al. A rule-out strategy based on high-sensitivity troponin and HEART score reduces hospital admissions. Ann Emerg Med. 2019;73(5):491–499. doi: 10.1016/j.annemergmed.2018.11.039.
   PubMed Web of Science ®Google Scholar
• Sanchis J, Valero E, García Blas S, et al. Undetectable high-sensitivity troponin in combination with clinical assessment for risk stratification of patients with chest pain and normal troponin at hospital arrival. Eur Heart J Acute Cardiovasc Care. 2020;9(6):567–575. doi: 10.1177/2048872620907539.
   PubMed Web of Science ®Google Scholar
• Pickering JW, Greenslade JH, Cullen L, et al. Assessment of the european society of cardiology 0-hour/1-hour algorithm to rule-out and rule-in acute myocardial infarction. Circulation. 2016;134(20):1532–1541. doi: 10.1161/CIRCULATIONAHA.116.022677.
   PubMed Web of Science ®Google Scholar
• Jaffe AS, White H. Ruling-in myocardial injury and ruling-out myocardial infarction with the european society of cardiology 1-hour algorithm. Circulation. 2016;134(20):1542–1545. doi: 10.1161/CIRCULATIONAHA.116.024687.
   PubMed Web of Science ®Google Scholar
• Vigen R, Kutscher P, Fernandez F, et al. Evaluation of a novel rule-out myocardial infarction protocol incorporating high-sensitivity troponin T in a US hospital. Circulation. 2018;138(18):2061–2063. doi: 10.1161/CIRCULATIONAHA.118.033861.
   PubMed Web of Science ®Google Scholar
• Kavsak PA, Clark L, Caruso N, et al. Caution when using high-sensitivity cardiac troponin I assay to rule out acute ischemia: when the Delta to rule in is within analytical variation. Can J Cardiol. 2020;36(7):1161.e11–1161.e12. doi: 10.1016/j.cjca.2020.03.011.
   PubMed Web of Science ®Google Scholar
• Kavsak PA, Don-Wauchope AC, Hill SA, et al. Acceptable analytical variation may exceed high-sensitivity cardiac troponin I cutoffs in early rule-out and rule-in acute myocardial infarction algorithms. Clin Chem. 2016;62(6):887–889. doi: 10.1373/clinchem.2016.255448.
   PubMed Web of Science ®Google Scholar
• Kavsak PA, Clark L, Jaffe AS. Effect of repeat measurements of high-sensitivity cardiac troponin on the same sample using the European Society of Cardiology 0-hour/1-hour or 2-hour algorithms for early rule-out and rule-in for myocardial infarction. Clin Chem. 2017;63(6):1163–1165. doi: 10.1373/clinchem.2017.272914.
   PubMed Web of Science ®Google Scholar
• Saenger AK, Beyrau R, Braun S, et al. Multicenter analytical evaluation of a high-sensitivity troponin T assay. Clin Chim Acta. 2011;412(9–10):748–754. doi: 10.1016/j.cca.2010.12.034.
   PubMed Web of Science ®Google Scholar
• Donato LJ, Wockenfus AM, Katzman BM, et al. Analytical and clinical considerations in implementing the Roche Elecsys troponin T Gen 5 STAT assay. Am J Clin Pathol. 2021;156(6):1121–1129. doi: 10.1093/ajcp/aqab082.
   PubMed Web of Science ®Google Scholar
• Kavsak PA, Hulett M, Worster A. Imprecision and delta criteria for a new ESC 0/2-hour algorithm. Clin Chem. 2022;68(5):721–722. doi: 10.1093/clinchem/hvac026.
   PubMed Web of Science ®Google Scholar
• Fraser CG. Reference change values. Clin Chem Lab Med. 2011;50(5):807–812.
   PubMed Web of Science ®Google Scholar
• Clerico A, Padoan A, Zaninotto M, et al. Clinical relevance of biological variation of cardiac troponins. Clin Chem Lab Med. 2021;59(4):641–652. doi: 10.1515/cclm-2020-1433.
   PubMed Web of Science ®Google Scholar
• Giannitsis E, Kurz K, Hallermayer K, et al. Analytical validation of a high-sensitivity cardiac troponin T assay. Clin Chem. 2010;56(2):254–261. doi: 10.1373/clinchem.2009.132654.
   PubMed Web of Science ®Google Scholar
• Lopez-Ayala P, Nestelberger T, Boeddinghaus J, et al. Novel criteria for the observe-zone of the ESC 0/1h-hs-cTnT algorithm. Circulation. 2021;144(10):773–787. doi: 10.1161/CIRCULATIONAHA.120.052982.
   PubMed Web of Science ®Google Scholar
• Collinson PO, Heung YM, Gaze D, et al. Influence of population selection on the 99th percentile reference value for cardiac troponin assays. Clin Chem. 2012;58(1):219–225. doi: 10.1373/clinchem.2011.171082.
   PubMed Web of Science ®Google Scholar
• Gore MO, Seliger SL, Defilippi CR, et al. Age- and sex-dependent upper reference limits for the high-sensitivity cardiac troponin T assay. J Am Coll Cardiol. 2014;63(14):1441–1448. doi: 10.1016/j.jacc.2013.12.032.
   PubMed Web of Science ®Google Scholar
• Apple FS, Wu AHB, Sandoval Y, et al. Sex-specific 99th percentile upper reference limits for high sensitivity cardiac troponin assays derived using a universal sample bank. Clin Chem. 2020;66(3):434–444. doi: 10.1093/clinchem/hvz029.
   PubMed Web of Science ®Google Scholar
• Normann J, Mueller M, Biener M, et al. Effect of older age on diagnostic and prognostic performance of high-sensitivity troponin T in patients presenting to an emergency department. Am Heart J. 2012;164(5):698–705.e4. doi: 10.1016/j.ahj.2012.08.003.
   PubMed Web of Science ®Google Scholar
• Parikh RH, Seliger SL, deFilippi CR. Use and interpretation of high sensitivity cardiac troponins in patients with chronic kidney disease with and without acute myocardial infarction. Clin Biochem. 2015;48(4–5):247–253. doi: 10.1016/j.clinbiochem.2015.01.004.
   PubMed Web of Science ®Google Scholar
• Boeddinghaus J, Nestelberger T, Twerenbold R, et al. Impact of age on the performance of the ESC 0/1h-algorithms for early diagnosis of myocardial infarction. Eur Heart J. 2018;39(42):3780–3794. doi: 10.1093/eurheartj/ehy514.
   PubMed Web of Science ®Google Scholar
• Miller-Hodges E, Anand A, Shah ASV, et al. High-sensitivity cardiac troponin and the risk stratification of patients with renal impairment presenting with suspected acute coronary syndrome. Circulation. 2018;137(5):425–435. doi: 10.1161/CIRCULATIONAHA.117.030320.
   PubMed Web of Science ®Google Scholar
• Olivieri F, Galeazzi R, Giavarina D, et al. Aged-related increase of high sensitive troponin T and its implication in acute myocardial infarction diagnosis of elderly patients. Mech Ageing Dev. 2012;133(5):300–305. doi: 10.1016/j.mad.2012.03.005.
   PubMed Web of Science ®Google Scholar
• Reiter M, Twerenbold R, Reichlin T, et al. Early diagnosis of acute myocardial infarction in the elderly using more sensitive cardiac troponin assays. Eur Heart J. 2011;32(11):1379–1389. doi: 10.1093/eurheartj/ehr033.
   PubMed Web of Science ®Google Scholar
• Rubini Giménez M, Twerenbold R, Boeddinghaus J, et al. Clinical effect of sex-specific cutoff values of high-sensitivity cardiac troponin T in suspected myocardial infarction. JAMA Cardiol. 2016;1(8):912–920. doi: 10.1001/jamacardio.2016.2882.
   PubMed Web of Science ®Google Scholar
• Mueller-Hennessen M, Lindahl B, Giannitsis E, et al. Diagnostic and prognostic implications using age- and gender-specific cut-offs for high-sensitivity cardiac troponin T – sub-analysis from the TRAPID-AMI study. Int J Cardiol. 2016;209:26–33. doi: 10.1016/j.ijcard.2016.01.213.
   PubMed Web of Science ®Google Scholar
• Eggers KM, Jernberg T, Lindahl B. Prognostic importance of sex-specific cardiac troponin T 99(th) percentiles in suspected acute coronary syndrome. Am J Med. 2016;129(8):880.e1–e12. doi: 10.1016/j.amjmed.2016.02.047.
   PubMed Web of Science ®Google Scholar
• Moehring B, Mueller M, Rubini Gimenez M, et al. Impact of gender-specific reference values of high-sensitivity troponin T on the prevalence and long-term outcome of acute myocardial infarction. Eur Heart J. 2013;34(Suppl 1):P4042. doi: 10.1093/eurheartj/eht309.P4042.
   Google Scholar
• Cullen L, Greenslade JH, Carlton EW, et al. Sex-specific versus overall cut points for a high sensitivity troponin I assay in predicting 1-year outcomes in emergency patients presenting with chest pain. Heart. 2016;102(2):120–126. doi: 10.1136/heartjnl-2015-308506.
   PubMed Web of Science ®Google Scholar
• Mueller T, Egger M, Peer E, et al. Evaluation of sex-specific cut-off values of high-sensitivity cardiac troponin I and T assays in an emergency department setting – Results from the linz troponin (LITROP) study. Clin Chim Acta. 2018;487:66–74. doi: 10.1016/j.cca.2018.09.026.
   PubMed Web of Science ®Google Scholar
• Bohula May EA, Bonaca MP, Jarolim P, et al. Prognostic performance of a high-sensitivity cardiac troponin I assay in patients with non-ST-elevation acute coronary syndrome. Clin Chem. 2014;60(1):158–164. doi: 10.1373/clinchem.2013.206441.
   PubMed Web of Science ®Google Scholar
• McRae A, Graham M, Abedin T, et al. Sex-specific, high-sensitivity cardiac troponin T cut-off concentrations for ruling out acute myocardial infarction with a single measurement. CJEM. 2019;21(1):26–33. doi: 10.1017/cem.2018.435.
   PubMedGoogle Scholar
• de Lemos JA, Drazner MH, Omland T, et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. JAMA. 2010;304(22):2503–2512. doi: 10.1001/jama.2010.1768.
   PubMed Web of Science ®Google Scholar
• McKie PM, Heublein DM, Scott CG, et al. Defining high-sensitivity cardiac troponin concentrations in the community. Clin Chem. 2013;59(7):1099–1107. doi: 10.1373/clinchem.2012.198614.
   PubMed Web of Science ®Google Scholar
• Apple FS, Simpson PA, Murakami MM. Defining the serum 99th percentile in a normal reference population measured by a high-sensitivity cardiac troponin I assay. Clin Biochem. 2010;43(12):1034–1036. doi: 10.1016/j.clinbiochem.2010.05.014.
   PubMed Web of Science ®Google Scholar
• Chenevier-Gobeaux C, Meune C, Freund Y, et al. Influence of age and renal function on high-sensitivity cardiac troponin T diagnostic accuracy for the diagnosis of acute myocardial infarction. Am J Cardiol. 2013;111(12):1701–1707. doi: 10.1016/j.amjcard.2013.02.024.
   PubMed Web of Science ®Google Scholar
• Twerenbold R, Wildi K, Jaeger C, et al. Optimal cutoff levels of more sensitive cardiac troponin assays for the early diagnosis of myocardial infarction in patients with renal dysfunction. Circulation. 2015;131(23):2041–2050. doi: 10.1161/CIRCULATIONAHA.114.014245.
   PubMed Web of Science ®Google Scholar
• Kraus D, von Jeinsen B, Tzikas S, et al. Cardiac troponins for the diagnosis of acute myocardial infarction in chronic kidney disease. J Am Heart Assoc. 2018;7(19):e008032. doi: 10.1161/JAHA.117.008032.
   PubMed Web of Science ®Google Scholar
• Than MP, Pickering JW, Sandoval Y, et al. Machine learning to predict the likelihood of acute myocardial infarction. Circulation. 2019;140(11):899–909. doi: 10.1161/CIRCULATIONAHA.119.041980.
   PubMed Web of Science ®Google Scholar
• Liu L, Cai X, Love T, et al. Using logistic regression models to investigate the effects of high-sensitivity cardiac troponin T confounders on ruling in acute myocardial infarction. Clin Chem Lab Med. 2023;61(7):1335–1342. doi: 10.1515/cclm-2022-1004.
   PubMed Web of Science ®Google Scholar
• Lippi G, Cervellin G. Identification of troponin determinants for improving its diagnostic performance in the emergency department. J Emerg Med. 2012;43(6):e487–e488. doi: 10.1016/j.jemermed.2012.05.016.
   PubMed Web of Science ®Google Scholar
• Ashburn NP, Snavely AC, O'Neill JC, et al. Performance of the european society of cardiology 0/1-hour algorithm with high-sensitivity cardiac troponin T among patients with known coronary artery disease. JAMA Cardiol. 2023;8(4):347–356. doi: 10.1001/jamacardio.2023.0031.
   PubMed Web of Science ®Google Scholar
• Liu Y, Wang Y, Huang C, et al. Estimating personalized diagnostic rules depending on individualized characteristics. Stat Med. 2017;36(7):1099–1117. doi: 10.1002/sim.7182.
   PubMed Web of Science ®Google Scholar
• Lippi G, Cervellin G. Letter by lippi and cervellin regarding article, optimal cutoff levels of more sensitive cardiac troponin assays for the early diagnosis of myocardial infarction in patients with renal dysfunction. Circulation. 2016;133(5):e374. doi: 10.1161/CIRCULATIONAHA.115.018157.
   PubMedGoogle Scholar
• Frankenstein L, Wu AH, Hallermayer K, et al. Biological variation and reference change value of high-sensitivity troponin T in healthy individuals during short and intermediate follow-up periods. Clin Chem. 2011;57(7):1068–1071. doi: 10.1373/clinchem.2010.158964.
   PubMed Web of Science ®Google Scholar
• Boeddinghaus J, Reichlin T, Cullen L, et al. Two-hour algorithm for triage toward rule-out and rule-in of acute myocardial infarction by use of high-sensitivity cardiac troponin I. Clin Chem. 2016;62(3):494–504. doi: 10.1373/clinchem.2015.249508.
   PubMed Web of Science ®Google Scholar
• Nestelberger T, Boeddinghaus J, Greenslade J, et al. Two-hour algorithm for rapid triage of suspected acute myocardial infarction using a high-sensitivity cardiac troponin I assay. Clin Chem. 2019;65(11):1437–1447. doi: 10.1373/clinchem.2019.305193.
   PubMed Web of Science ®Google Scholar