Omics-based novel strategies in the diagnosis of endometriosis

References

• Sivajohan B, Elgendi M, Menon C, et al. Clinical use of artificial intelligence in endometriosis: a scoping review. NPJ Digit Med. 2022;5(1):109. doi: 10.1038/s41746-022-00638-1.
   PubMed Web of Science ®Google Scholar
• Vladimirovna SV. Epidemiology, theories of the development, conservative and operative treatment of the endometriosis. Peerian J. 2023;15:84–93.
   Google Scholar
• Nnoaham KE, Hummelshoj L, Webster P, et al. Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil Steril. 2011;96(2):366–373. e8. doi: 10.1016/j.fertnstert.2011.05.090.
   PubMed Web of Science ®Google Scholar
• Sivajohan B, Lin T, Bedaiwy MA. Cost estimates associated with diagnosis and treatment of endometriosis. In: Endometriosis and adenomyosis: global perspectives across the lifespan. Cham: Springer; 2022. p. 361–395.
   Google Scholar
• Hoogstad-van Evert J, Paap R, Nap A, et al. The promises of natural killer cell therapy in endometriosis. Int J Mol Sci. 2022;23(10):5539. doi: 10.3390/ijms23105539.
   PubMed Web of Science ®Google Scholar
• Jamali N, Zal F, Mostafavi-Pour Z, et al. Ameliorative effects of quercetin and metformin and their combination against experimental endometriosis in rats. Reprod Sci. 2021;28(3):683–692. doi: 10.1007/s43032-020-00377-2.
   PubMed Web of Science ®Google Scholar
• Rea T, Giampaolino P, Simeone S, et al. Living with endometriosis: a phenomenological study. Int J Qual Stud Health Well-Being. 2020;15(1):1822621. doi: 10.1080/17482631.2020.1822621.
   PubMed Web of Science ®Google Scholar
• Tripoli TM, Sato H, Sartori MG, et al. Evaluation of quality of life and sexual satisfaction in women suffering from chronic pelvic pain with or without endometriosis. J Sex Med. 2011;8(2):497–503. doi: 10.1111/j.1743-6109.2010.01976.x.
   PubMed Web of Science ®Google Scholar
• Cousins FL, McKinnon BD, Mortlock S, et al. New concepts on the etiology of endometriosis. J Obstet Gynaecol Res. 2023;49(4):1090–1105. doi: 10.1111/jog.15549.
   PubMed Web of Science ®Google Scholar
• Lamceva J, Uljanovs R, Strumfa I. The main theories on the pathogenesis of endometriosis. Int J Mol Sci. 2023;24(5):4254. doi: 10.3390/ijms24054254.
   PubMed Web of Science ®Google Scholar
• Samare-Najaf M, Samareh A, Namavar Jahromi B, et al. Female infertility caused by organophosphates: an insight into the latest biochemical and histomorphological findings. Toxin Reviews. 2023;42(1):419–446. doi: 10.1080/15569543.2022.2120897.
   Web of Science ®Google Scholar
• Cuccu I, D'Oria O, Sgamba L, et al. Role of genomic and molecular biology in the modulation of the treatment of endometrial cancer: narrative review and perspectives. Healthcare. 2023;11(4):571. editors MDPI. doi: 10.3390/healthcare11040571.
   Web of Science ®Google Scholar
• Psilopatis I, Vrettou K, Fleckenstein FN, et al. The impact of histone modifications in endometriosis highlights new therapeutic opportunities. Cells. 2023;12(9):1227. doi: 10.3390/cells12091227.
   PubMed Web of Science ®Google Scholar
• Vazgiourakis VM, Zervou MI, Papageorgiou L, et al. Association of endometriosis with cardiovascular disease: genetic aspects. Int J Mol Med. 2023;51(3):1–16. doi: 10.3892/ijmm.2023.5232.
   PubMed Web of Science ®Google Scholar
• Brosens I, Benagiano G. Is neonatal uterine bleeding involved in the pathogenesis of endometriosis as a source of stem cells? Fertil Steril. 2013;100(3):622–623. doi: 10.1016/j.fertnstert.2013.04.046.
   PubMed Web of Science ®Google Scholar
• Kobayashi H, Iwai K, Niiro E, et al. Fetal programming theory: implication for the understanding of endometriosis. Hum Immunol. 2014;75(3):208–217. doi: 10.1016/j.humimm.2013.12.012.
   PubMed Web of Science ®Google Scholar
• Signorile PG, Viceconte R, Baldi A. New insights in pathogenesis of endometriosis. Front Med. 2022;9:879015. PubMed PMID: 35572957; PubMed Central PMCID: PMCPMC9095948. eng. doi: 10.3389/fmed.2022.879015.
   Web of Science ®Google Scholar
• Wykes CB, Clark TJ, Khan KS. Accuracy of laparoscopy in the diagnosis of endometriosis: a systematic quantitative review. BJOG. 2004;111(11):1204–1212. doi: 10.1111/j.1471-0528.2004.00433.x.
   PubMed Web of Science ®Google Scholar
• Nisenblat V, Bossuyt PM, Farquhar C, et al. Imaging modalities for the non-invasive diagnosis of endometriosis. Cochrane Database Syst Rev. 2016;2016(2):CD009591. doi: 10.1002/14651858.CD009591.pub2.
   Google Scholar
• Abbott J, Hawe J, Hunter D, et al. Laparoscopic excision of endometriosis: a randomized, placebo-controlled trial. Fertil Steril. 2004;82(4):878–884. doi: 10.1016/j.fertnstert.2004.03.046.
   PubMed Web of Science ®Google Scholar
• Chapron C, Querleu D, Bruhat M-A, et al. Surgical complications of diagnostic and operative gynaecological laparoscopy: a series of 29,966 cases. Hum Reprod. 1998;13(4):867–872. doi: 10.1093/humrep/13.4.867.
   PubMed Web of Science ®Google Scholar
• Pascoal E, Wessels J, Aas-Eng M, et al. Strengths and limitations of diagnostic tools for endometriosis and relevance in diagnostic test accuracy research. Ultrasound Obstet Gyne. 2022;60(3):309–327. doi: 10.1002/uog.24892.
   PubMed Web of Science ®Google Scholar
• Albee RB, Jr, Sinervo K, Fisher DT. Laparoscopic excision of lesions suggestive of endometriosis or otherwise atypical in appearance: relationship between visual findings and final histologic diagnosis. J Minim Invasive Gynecol. 2008;15(1):32–37. doi: 10.1016/j.jmig.2007.08.619.
   PubMed Web of Science ®Google Scholar
• Mahini SM, Mortazavi G, Samare-Najaf M, et al. Non-invasive diagnosis of endometriosis: immunologic and genetic markers. Clin Chim Acta. 2022;538:70–86.
   PubMed Web of Science ®Google Scholar
• Alexandersson E, Jacobson D, Vivier MA, et al. Field-omics—understanding large-scale molecular data from field crops. Front Plant Sci. 2014;5:286. doi: 10.3389/fpls.2014.00286.
   PubMed Web of Science ®Google Scholar
• Leclercq M, Vittrant B, Martin-Magniette ML, et al. Large-scale automatic feature selection for biomarker discovery in high-dimensional OMICs data. Front Genet. 2019;10:452. doi: 10.3389/fgene.2019.00452.
   PubMed Web of Science ®Google Scholar
• Goulielmos GN, Matalliotakis M, Matalliotaki C, et al. Endometriosis research in the -omics era. Gene. 2020;741:144545. doi: 10.1016/j.gene.2020.144545.
   PubMed Web of Science ®Google Scholar
• Lesk AM. Introduction to genomics. Oxford: Oxford University Press; 2017.
   Google Scholar
• Wang Q, Lu Q, Zhao H. A review of study designs and statistical methods for genomic epidemiology studies using next generation sequencing. Front Genet. 2015;6:149. doi: 10.3389/fgene.2015.00149.
   PubMed Web of Science ®Google Scholar
• Nakagawa H. Prostate cancer genomics by high-throughput technologies: genome-wide association study and sequencing analysis. Endocr Relat Cancer. 2013;20(4):R171–R181. doi: 10.1530/ERC-13-0113.
   PubMed Web of Science ®Google Scholar
• Saha R, Pettersson HJ, Svedberg P, et al. Heritability of endometriosis. Fertil Steril. 2015;104(4):947–952. doi: 10.1016/j.fertnstert.2015.06.035.
   PubMed Web of Science ®Google Scholar
• Nouri K, Ott J, Krupitz B, et al. Family incidence of endometriosis in first-, second-, and third-degree relatives: case-control study. Reprod Biol Endocrinol. 2010;8(1):85. doi: 10.1186/1477-7827-8-85.
   PubMedGoogle Scholar
• Gajbhiye R, McKinnon B, Mortlock S, et al. Genetic variation at chromosome 2q13 and its potential influence on endometriosis susceptibility through effects on the IL-1 family. Reprod Sci. 2018;25(9):1307–1317. doi: 10.1177/1933719118768688.
   PubMed Web of Science ®Google Scholar
• Samare-Najaf M, Zal F, Jamali N, et al. Do quercetin and vitamin E properties preclude doxorubicin-induced stress and inflammation in reproductive tissues? CCTR. 2022;18(4):292–302. doi: 10.2174/1573394718666220726105843.
   Google Scholar
• Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420(6917):860–867. doi: 10.1038/nature01322.
   PubMed Web of Science ®Google Scholar
• Fenneman AC, Weidner M, Chen LA, et al. Antibiotics in the pathogenesis of diabetes and inflammatory diseases of the gastrointestinal tract. Nat Rev Gastroenterol Hepatol. 2023;20(2):81–100. doi: 10.1038/s41575-022-00685-9.
   PubMed Web of Science ®Google Scholar
• Badie A, Saliminejad K, Salahshourifar I, et al. Interleukin 1 alpha (IL1A) polymorphisms and risk of endometriosis in iranian population: a case-control study. Gynecol Endocrinol. 2020;36(2):135–138. doi: 10.1080/09513590.2019.1631790.
   PubMed Web of Science ®Google Scholar
• Wang X, Hu M, Chen J, et al. Effects of gene polymorphism and serum levels of IL-2 and IL-6 on endometriosis. Eur Rev Med Pharmacol Sci. 2020;24(9):4635–4641.
   PubMed Web of Science ®Google Scholar
• Marchionni E, Porpora MG, Megiorni F, et al. TLR4 T399I polymorphism and endometriosis in a cohort of italian women. Diagnostics. 2020;10(5):255. doi: 10.3390/diagnostics10050255.
   Web of Science ®Google Scholar
• Babah OA, Ojewunmi OO, Osuntoki AA, et al. Genetic polymorphisms of vascular endothelial growth factor (VEGF) associated with endometriosis in Nigerian women. Hum Genomics. 2021;15(1):64. doi: 10.1186/s40246-021-00364-x.
   PubMed Web of Science ®Google Scholar
• Milewski Ł, Ścieżyńska A, Ponińska J, et al. Endometriosis is associated with functional polymorphism in the promoter of heme oxygenase 1 (HMOX1) gene. Cells. 2021;10(3):695. doi: 10.3390/cells10030695.
   PubMed Web of Science ®Google Scholar
• Chen G, Zhang M, Liang Z, et al. Association of polymorphisms in MALAT1 with the risk of endometriosis in Southern Chinese women. Biol Reprod. 2020;102(4):943–949. doi: 10.1093/biolre/ioz218.
   PubMed Web of Science ®Google Scholar
• Cardoso JV, Medeiros R, Dias F, et al. DROSHA rs10719 and DICER1 rs3742330 polymorphisms in endometriosis and different diseases: case-control and review studies. Exp Mol Pathol. 2021;119:104616. doi: 10.1016/j.yexmp.2021.104616.
   PubMed Web of Science ®Google Scholar
• Golovchenko I, Aizikovich B, Golovchenko O, et al. Sex hormone candidate gene polymorphisms are associated with endometriosis. Int J Mol Sci. 2022;23(22):13691. doi: 10.3390/ijms232213691.
   PubMed Web of Science ®Google Scholar
• Szaflik T, Smolarz B, Romanowicz H, et al. Polymorphisms in the 3′ UTR region of ESR2 and CYP19A1 genes in women with endometriosis. Eur J Obstet Gynecol Reprod Biol. 2020;250:241–245. doi: 10.1016/j.ejogrb.2020.05.023.
   PubMed Web of Science ®Google Scholar
• Tanase A, Nemescu D, Popescu R, et al. FSH receptor and FSH beta chain polymorphism involvement in infertility and endometriosis disease. Acta Endocrinol. 2020;16(2):142–147. doi: 10.4183/aeb.2020.142.
   Google Scholar
• Masuda T, Low S-K, Akiyama M, et al. GWAS of five gynecologic diseases and cross-trait analysis in japanese. Eur J Hum Genet. 2020;28(1):95–107. doi: 10.1038/s41431-019-0495-1.
   PubMed Web of Science ®Google Scholar
• Mortlock S, Corona RI, Kho PF, et al. A multi-level investigation of the genetic relationship between endometriosis and ovarian cancer histotypes. Cell Rep Med. 2022;3(3):100542. doi: 10.1016/j.xcrm.2022.100542.
   PubMedGoogle Scholar
• Gallagher C, Mäkinen N, Harris H, et al. Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis. Nat Commun. 2019;10(1):4857. doi: 10.1038/s41467-019-12536-4.
   PubMedGoogle Scholar
• Adewuyi EO, Mehta D, Nyholt D. Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways. Hum Reprod. 2022;37(2):366–383. doi: 10.1093/humrep/deab254.
   PubMed Web of Science ®Google Scholar
• Yang F, Mortlock S, MacGregor S, et al. Genetic relationship between endometriosis and melanoma. Front Reprod Health. 2021;3:711123. doi: 10.3389/frph.2021.711123.
   PubMedGoogle Scholar
• Koller D, Pathak GA, Wendt FR, et al. Epidemiologic and genetic associations of endometriosis with depression, anxiety, and eating disorders. JAMA Netw Open. 2023;6(1):e2251214-e2251214. doi: 10.1001/jamanetworkopen.2022.51214.
   Web of Science ®Google Scholar
• Celik O, Celik N, Zan E, et al. Genome-wide expression analysis of endometrium before and after endometrioma surgery. Eur J Obstet Gynecol Reprod Biol. 2020;253:141–147. doi: 10.1016/j.ejogrb.2020.08.036.
   PubMed Web of Science ®Google Scholar
• Marla S, Mortlock S, Houshdaran S, et al. Genetic risk factors for endometriosis near estrogen receptor 1 and coexpression of genes in this region in endometrium. Mol Hum Reprod. 2021;27(1):gaaa082. doi: 10.1093/molehr/gaaa082.
   PubMed Web of Science ®Google Scholar
• Huang Y, Luo J, Zhang Y, et al. Identification of MKNK1 and TOP3A as ovarian endometriosis risk-associated genes using integrative genomic analyses and functional experiments. Comput Struct Biotechnol J. 2023;21:1510–1522. doi: 10.1016/j.csbj.2023.02.001.
   PubMed Web of Science ®Google Scholar
• Gaia-Oltean AI, Pop LA, Cojocneanu RM, et al. The shifting landscape of genetic alterations separating endometriosis and ovarian endometrioid carcinoma. Am J Cancer Res. 2021;11(4):1754.
   PubMed Web of Science ®Google Scholar
• Suda K, Nakaoka H, Yoshihara K, et al. Clonal expansion and diversification of cancer-associated mutations in endometriosis and normal endometrium. Cell Rep. 2018;24(7):1777–1789. doi: 10.1016/j.celrep.2018.07.037.
   PubMed Web of Science ®Google Scholar
• Yachida N, Yoshihara K, Suda K, et al. Biological significance of KRAS mutant allele expression in ovarian endometriosis. Cancer Sci. 2021;112(5):2020–2032. doi: 10.1111/cas.14871.
   PubMed Web of Science ®Google Scholar
• Wilson MR, Reske JJ, Holladay J, et al. ARID1A mutations promote p300-dependent endometrial invasion through super-enhancer hyperacetylation. Cell Rep. 2020;33(6):108366. doi: 10.1016/j.celrep.2020.108366.
   PubMed Web of Science ®Google Scholar
• Zhang H-B, Li Y, Wu J-L, et al. Genetic variation of glutathione S-transferase M1 is associated with patients with ovarian endometriosis and endometriosis-related primary infertility. Public Health Genomics. 2021;24(5-6):261–266. doi: 10.1159/000517266.
   PubMed Web of Science ®Google Scholar
• Yachida N, Yoshihara K, Suda K, et al. ARID1A protein expression is retained in ovarian endometriosis with ARID1A loss-of-function mutations: implication for the two-hit hypothesis. Sci Rep. 2020;10(1):14260. doi: 10.1038/s41598-020-71273-7.
   PubMed Web of Science ®Google Scholar
• Peng L-S, Li Z-M, Chen G, et al. Frequent DYSF rare variants/mutations in 152 Han Chinese samples with ovarian endometriosis. Arch Gynecol Obstet. 2021;304(3):671–677. doi: 10.1007/s00404-021-06094-8.
   PubMed Web of Science ®Google Scholar
• Harbottle A, Maggrah A, Usher R, et al. A novel 8.7-kb mitochondrial genome deletion accurately detects endometriosis in the plasma of symptomatic women. Biomark Med. 2020;14(2):97–107. doi: 10.2217/bmm-2019-0451.
   PubMed Web of Science ®Google Scholar
• Deryabin PI, Borodkina AV. Epigenetic clocks provide clues to the mystery of uterine ageing. Hum Reprod Update. 2023;29(3):259–271. doi: 10.1093/humupd/dmac042.
   PubMed Web of Science ®Google Scholar
• Lei L, Xu X, Gong C, et al. Integrated analysis of genome-wide gene expression and DNA methylation profiles reveals candidate genes in ovary endometriosis. Front Endocrinol. 2023;14:1093683. doi: 10.3389/fendo.2023.1093683.
   PubMed Web of Science ®Google Scholar
• Xue W, Yao X, Ting G, et al. BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis. Environ Pollut. 2021;268(Pt B):115748. doi: 10.1016/j.envpol.2020.115748.
   PubMedGoogle Scholar
• Houshdaran S, Oke AB, Fung JC, et al. Steroid hormones regulate genome-wide epigenetic programming and gene transcription in human endometrial cells with marked aberrancies in endometriosis. PLoS Genet. 2020;16(6):e1008601. doi: 10.1371/journal.pgen.1008601.
   PubMed Web of Science ®Google Scholar
• Gerkowicz SA, Curtis SW, Knight AK, et al. Endometriosis, endocrine disrupters, and epigenetics: an investigation into the complex interplay in women with polybrominated biphenyl exposure and endometriosis. J Assist Reprod Genet. 2020;37(2):427–436. doi: 10.1007/s10815-020-01695-9.
   PubMed Web of Science ®Google Scholar
• Leap K, Yotova I, Horvath S, et al. Epigenetic age provides insight into tissue origin in endometriosis. Sci Rep. 2022;12(1):21281. doi: 10.1038/s41598-022-25416-7.
   PubMed Web of Science ®Google Scholar
• Zhao W, Lei L, Chen R, et al. The association between deoxyribonucleic acid hypermethylation in intron VII and human leukocyte antigen-C∗07 expression in patients with endometriosis. Int J Clin Pract. 2023;2023:2291156–2291159. doi: 10.1155/2023/2291156.
   PubMed Web of Science ®Google Scholar
• Adamczyk M, Rawłuszko-Wieczorek AA, Wirstlein P, et al. Assessment of TET1 gene expression, DNA methylation and H3K27me3 level of its promoter region in eutopic endometrium of women with endometriosis and infertility. Biomed Pharmacother. 2022;150:112989. doi: 10.1016/j.biopha.2022.112989.
   PubMed Web of Science ®Google Scholar
• Esfandiari F, Favaedi R, Heidari-Khoei H, et al. Insight into epigenetics of human endometriosis organoids: DNA methylation analysis of HOX genes and their cofactors. Fertil Steril. 2021;115(1):125–137. doi: 10.1016/j.fertnstert.2020.08.1398.
   PubMed Web of Science ®Google Scholar
• Joshi NR, Kohan-Ghadr H-R, Roqueiro DS, et al. Genetic and epigenetic changes in the eutopic endometrium of women with endometriosis: association with decreased endometrial αvβ3 integrin expression. Mol Hum Reprod. 2021;27(6):gaab018. doi: 10.1093/molehr/gaab018.
   PubMed Web of Science ®Google Scholar
• Saare M, Modhukur V, Suhorutshenko M, et al. The influence of menstrual cycle and endometriosis on endometrial methylome. Clin Epigenetics. 2016;8(1):2. doi: 10.1186/s13148-015-0168-z.
   PubMedGoogle Scholar
• Toniyan KA, Gorbacheva EY, Boyarintsev VV, et al. Endometriosis of the cervix: a rare clinical case with the possibility of comparing the eutopic and ectopic endometrium at the cellular level. Int J Mol Sci. 2023;24(3):2184. doi: 10.3390/ijms24032184.
   PubMed Web of Science ®Google Scholar
• Colón-Díaz M, Báez-Vega P, García M, et al. HDAC1 and HDAC2 are differentially expressed in endometriosis. Reprod Sci. 2012;19(5):483–492. doi: 10.1177/1933719111432870.
   PubMed Web of Science ®Google Scholar
• Kawano Y, Nasu K, Li H, et al. Application of the histone deacetylase inhibitors for the treatment of endometriosis: histone modifications as pathogenesis and novel therapeutic target. Hum Reprod. 2011;26(9):2486–2498. doi: 10.1093/humrep/der203.
   PubMed Web of Science ®Google Scholar
• Samartzis EP, Noske A, Samartzis N, et al. The expression of histone deacetylase 1, but not other class I histone deacetylases, is significantly increased in endometriosis. Reprod Sci. 2013;20(12):1416–1422. doi: 10.1177/1933719113488450.
   PubMed Web of Science ®Google Scholar
• Blumenberg M. Introductory chapter: transcriptome analysis. Transcriptome Analysis. 2019;370:1–5.
   Google Scholar
• Liang K-H. Transcriptomics. In: Liang K-H, editor. Bioinformatics for biomedical science and clinical applications. Cambridge: Woodhead Publishing; 2013. p. 49–82.
   Google Scholar
• Tarca AL, Romero R, Draghici S. Analysis of microarray experiments of gene expression profiling. Am J Obstet Gynecol. 2006;195(2):373–388. doi: 10.1016/j.ajog.2006.07.001.
   PubMed Web of Science ®Google Scholar
• Bhat MA, Sharma JB, Roy KK, et al. Genomic evidence of Y chromosome microchimerism in the endometrium during endometriosis and in cases of infertility. Reprod Biol Endocrinol. 2019;17(1):1–10. doi: 10.1186/s12958-019-0465-z.
   PubMedGoogle Scholar
• Geng R, Huang X, Li L, et al. Gene expression analysis in endometriosis: immunopathology insights, transcription factors and therapeutic targets. Front Immunol. 2022;13:1037504. doi: 10.3389/fimmu.2022.1037504.
   PubMed Web of Science ®Google Scholar
• Qi H, Zhang H, Zhao X, et al. Integrated analysis of mRNA and protein expression profiling in tubal endometriosis. Reproduction. 2020;159(5):601–614. doi: 10.1530/REP-19-0587.
   PubMed Web of Science ®Google Scholar
• Zhong Q, Yang F, Chen X, et al. Patterns of immune infiltration in endometriosis and their relationship to r-AFS stages. Front Genet. 2021;12:631715. doi: 10.3389/fgene.2021.631715.
   PubMed Web of Science ®Google Scholar
• Iwasaki S, Kaneda K. Genes relating to biological processes of endometriosis: expression changes common to a mouse model and patients. Drug Res. 2022;72(9):523–533. doi: 10.1055/a-1894-6817.
   Google Scholar
• Gu C-L, Zhang Z, Fan W-S, et al. Identification of microRNAs as potential biomarkers in ovarian endometriosis. Reprod Sci. 2020;27(9):1715–1723. doi: 10.1007/s43032-020-00148-z.
   PubMed Web of Science ®Google Scholar
• Takebayashi K, Nasu K, Okamoto M, et al. Hsa-miR-100-5p, an overexpressed miRNA in human ovarian endometriotic stromal cells, promotes invasion through attenuation of SMARCD1 expression. Reprod Biol Endocrinol. 2020;18(1):1–10. doi: 10.1186/s12958-020-00590-3.
   PubMed Web of Science ®Google Scholar
• Bendifallah S, Suisse S, Puchar A, et al. Salivary MicroRNA signature for diagnosis of endometriosis. J Clin Med. 2022;11(3):612. doi: 10.3390/jcm11030612.
   PubMed Web of Science ®Google Scholar
• Jamali N, Mostafavi-Pour Z, Zal F, et al. Antioxidant ameliorative effect of caffeic acid on the ectopic endometrial cells separated from patients with endometriosis. Taiwan J Obstet Gynecol. 2021; Mar60(2):216–220. PubMed PMID: 33678318; eng. doi: 10.1016/j.tjog.2020.12.003.
   PubMed Web of Science ®Google Scholar
• Samare-Najaf M, Zal F, Safari S. Primary and secondary markers of doxorubicin-induced female infertility and the alleviative properties of quercetin and vitamin E in a rat model. Reprod Toxicol. 2020;96:316–326. doi: 10.1016/j.reprotox.2020.07.015.
   PubMed Web of Science ®Google Scholar
• Shen L, Hong X, Zhou W, et al. Expression profiles of tRNA-derived fragments and their potential roles in ovarian endometriosis. Epigenomics. 2020; Feb12(3):183–197. PubMed PMID: 31845823; eng. doi: 10.2217/epi-2019-0277.
   PubMed Web of Science ®Google Scholar
• He Y, Li J, Qu Y, et al. Identification and analysis of potential Immune-Related biomarkers in endometriosis. J Immunol Res. 2023;2023:2975581–2975521. doi: 10.1155/2023/2975581.
   PubMed Web of Science ®Google Scholar
• Luddi A, Marrocco C, Governini L, et al. Expression of matrix metalloproteinases and their inhibitors in endometrium: high levels in endometriotic lesions. Int J Mol Sci. 2020;21(8):2840. doi: 10.3390/ijms21082840.
   PubMed Web of Science ®Google Scholar
• Wu R-F, Chen Z-X, Zhou W-D, et al. High expression of ZEB1 in endometriosis and its role in 17β-estradiol-induced epithelial-mesenchymal transition. Int J Clin Exp Path. 2018;11(10):4744.
   PubMed Web of Science ®Google Scholar
• Yilmaz BD, Sison CA, Yildiz S, et al. Genome-wide estrogen receptor-α binding and action in human endometrial stromal cells. F S Sci. 2020;1(1):59–66. doi: 10.1016/j.xfss.2020.06.002.
   PubMedGoogle Scholar
• Sahraei SS, Davoodi Asl F, Kalhor N, et al. A comparative study of gene expression in menstrual blood-derived stromal cells between endometriosis and healthy women. Biomed Res Int. 2022;2022:7053521–7053511. doi: 10.1155/2022/7053521.
   PubMed Web of Science ®Google Scholar
• Esfandiari F, Chitsazian F, Jahromi MG, et al. HOX cluster and their cofactors showed an altered expression pattern in eutopic and ectopic endometriosis tissues. Reprod Biol Endocrinol. 2021;19(1):1–10. doi: 10.1186/s12958-021-00816-y.
   PubMed Web of Science ®Google Scholar
• Lu Z, Gao Y. Screening differentially expressed genes between endometriosis and ovarian cancer to find new biomarkers for endometriosis. Ann Med. 2021;53(1):1377–1389. doi: 10.1080/07853890.2021.1966087.
   PubMed Web of Science ®Google Scholar
• Yu L, Shen H, Ren X, et al. Multi-omics analysis reveals the interaction between the complement system and the coagulation Cascade in the development of endometriosis. Sci Rep. 2021;11(1):11926. doi: 10.1038/s41598-021-90112-x.
   PubMed Web of Science ®Google Scholar
• Ponandai-Srinivasan S, Saare M, Boggavarapu NR, et al. Syndecan-1 modulates the invasive potential of endometrioma via TGF-β signalling in a subgroup of women with endometriosis. Hum Reprod. 2020;35(10):2280–2293. doi: 10.1093/humrep/deaa164.
   PubMed Web of Science ®Google Scholar
• Wei J, Huang B, Nong Y, et al. Identification of a novel cuproptosis-related gene signature in eutopic endometrium of women with endometriosis. Reprod. Sci. 2023;30(6):1841–1853. doi: 10.1007/s43032-022-01130-7.
   PubMed Web of Science ®Google Scholar
• Sun S, Guo J, Qu X, et al. The extracellular vesicular pseudogene LGMNP1 induces M2-like macrophage polarization by upregulating LGMN and serves as a novel promising predictive biomarker for ovarian endometriosis recurrence. Hum Reprod. 2022;37(3):447–465. doi: 10.1093/humrep/deab266.
   PubMed Web of Science ®Google Scholar
• Kumari P, Sharma I, Saha SC, et al. Diagnostic potential of differentially regulated microRNAs among endometriosis, endometrioid ovarian cancer, and endometrial cancer. J Cancer Res Ther. 2021;17(4):1003–1011. doi: 10.4103/jcrt.JCRT_969_19.
   PubMed Web of Science ®Google Scholar
• Chen P, Yao M, Fang T, et al. Identification of NFASC and CHL1 as two novel hub genes in endometriosis using integrated bioinformatic analysis and experimental verification. Pharmgenomics Pers Med. 2022;15:377–392. doi: 10.2147/PGPM.S354957.
   PubMed Web of Science ®Google Scholar
• Jiang L, Zhang M, Wang S, et al. LINC01018 and SMIM25 sponged miR-182-5p in endometriosis revealed by the ceRNA network construction. Int J Immunopathol Pharmacol. 2020;34:2058738420976309. doi: 10.1177/2058738420976309.
   Web of Science ®Google Scholar
• Wu J, Fang X, Xia X. Identification of key genes and pathways associated with endometriosis by weighted gene co-expression network analysis. Int J Med Sci. 2021;18(15):3425–3436. doi: 10.7150/ijms.63541.
   PubMed Web of Science ®Google Scholar
• Xie C, Yin Z, Liu Y. Analysis of characteristic genes and ceRNA regulation mechanism of endometriosis based on full transcriptional sequencing. Front Genet. 2022;13:902329. doi: 10.3389/fgene.2022.902329.
   PubMed Web of Science ®Google Scholar
• Wu J, Fang X, Huang H, et al. Construction and topological analysis of an endometriosis-related exosomal circRNA-miRNA-mRNA regulatory network. Aging. 2021;13(9):12607–12630. doi: 10.18632/aging.202937.
   PubMedGoogle Scholar
• Wu J, Huang H, Huang W, et al. Analysis of exosomal lncRNA, miRNA and mRNA expression profiles and ceRNA network construction in endometriosis. Epigenomics. 2020;12(14):1193–1213. doi: 10.2217/epi-2020-0084.
   PubMed Web of Science ®Google Scholar
• Abo C, Biquard L, Girardet L, et al. Unbiased in silico analysis of gene expression pinpoints circulating miRNAs targeting KIAA1324, a new gene drastically downregulated in ovarian endometriosis. Biomedicines. 2022;10(9):2065. doi: 10.3390/biomedicines10092065.
   PubMed Web of Science ®Google Scholar
• Zafari N, Tarafdari AM, Izadi P, et al. A panel of plasma miRNAs 199b-3p, 224-5p and let-7d-3p as non-invasive diagnostic biomarkers for endometriosis. Reprod Sci. 2021;28(4):991–999. doi: 10.1007/s43032-020-00415-z.
   PubMed Web of Science ®Google Scholar
• Zhang L, Li H, Yuan M, et al. Serum exosomal microRNAs as potential circulating biomarkers for endometriosis. Dis Markers. 2020;2020:1–10. doi: 10.1155/2020/2456340.
   Web of Science ®Google Scholar
• Mihara Y, Maekawa R, Sato S, et al. An integrated genomic approach identifies HOXC8 as an upstream regulator in ovarian endometrioma. J Clin Endocrinol Metab. 2020;105(12):e4474–e4489. doi: 10.1210/clinem/dgaa618.
   Web of Science ®Google Scholar
• Miller JE, Lingegowda H, Sisnett DJ, et al. T helper 17 axis and endometrial macrophage disruption in menstrual effluent provides potential insights into the pathogenesis of endometriosis. F S Sci. 2022;3(3):279–287. doi: 10.1016/j.xfss.2022.04.007.
   PubMedGoogle Scholar
• Feng X, Qi L, Xu X, et al. Analysis of differences in the transcriptomic profiles of eutopic and ectopic endometriums in women with ovarian endometriosis. PeerJ. 2021;9:e11045. doi: 10.7717/peerj.11045.
   PubMed Web of Science ®Google Scholar
• Ma J, Zhang L, Zhan H, et al. Single-cell transcriptomic analysis of endometriosis provides insights into fibroblast fates and immune cell heterogeneity. Cell Biosci. 2021;11(1):125. doi: 10.1186/s13578-021-00637-x.
   PubMed Web of Science ®Google Scholar
• Da Luz CM, Da Broi MG, Koopman L, et al. Transcriptomic analysis of cumulus cells shows altered pathways in patients with minimal and mild endometriosis. Sci Rep. 2022;12(1):5775. doi: 10.1038/s41598-022-09386-4.
   PubMed Web of Science ®Google Scholar
• Li B, Duan H, Wang S, et al. Ferroptosis resistance mechanisms in endometriosis for diagnostic model establishment. Reprod Biomed Online. 2021;43(1):127–138. doi: 10.1016/j.rbmo.2021.04.002.
   PubMed Web of Science ®Google Scholar
• Poli-Neto OB, Carlos D, Junior AF, et al. Eutopic endometrium from women with endometriosis and chlamydial endometritis share immunological cell types and DNA repair imbalance: a transcriptome meta-analytical perspective. J Reprod Immunol. 2021;145:103307. doi: 10.1016/j.jri.2021.103307.
   PubMed Web of Science ®Google Scholar
• Poli-Neto OB, Meola J, Rosa-e-Silva JC, et al. Transcriptome meta-analysis reveals differences of immune profile between eutopic endometrium from stage I-II and III-IV endometriosis independently of hormonal milieu. Sci Rep. 2020;10(1):313. doi: 10.1038/s41598-019-57207-y.
   PubMed Web of Science ®Google Scholar
• Wang C, Chen Z, Zhao X, et al. Transcriptome-based analysis reveals therapeutic effects of resveratrol on endometriosis in aRat model. Drug Des Devel Ther. 2021;15:4141–4155. doi: 10.2147/DDDT.S323790.
   PubMed Web of Science ®Google Scholar
• Xiang R, Chen P, Zeng Z, et al. Transcriptomic analysis shows surgical treatment is likely to influence the endometrial receptivity of patients with endometriosis. Front Endocrinol. 2022;13:932339. doi: 10.3389/fendo.2022.932339.
   PubMed Web of Science ®Google Scholar
• Yoo J-Y, Kim TH, Shin J-H, et al. Loss of MIG-6 results in endometrial progesterone resistance via ERBB2. Nat Commun. 2022;13(1):1101. doi: 10.1038/s41467-022-28608-x.
   PubMed Web of Science ®Google Scholar
• Devesa-Peiro A, Sebastian-Leon P, Pellicer A, et al. Guidelines for biomarker discovery in endometrium: correcting for menstrual cycle bias reveals new genes associated with uterine disorders. Mol Hum Reprod. 2021;27(4):gaab011. doi: 10.1093/molehr/gaab011.
   PubMed Web of Science ®Google Scholar
• Zhao W, Kang S, Zhao J, et al. Aberrant methylation of the IL-12B promotor region contributes to the risk of developing ovarian endometriosis. Mol Reprod Dev. 2019;86(6):632–638. doi: 10.1002/mrd.23139.
   PubMed Web of Science ®Google Scholar
• Zhang H, Kong W, Xie Y, et al. Telomere-related genes as potential biomarkers to predict endometriosis and immune response: Development of a machine learning-based risk model. Front Med. 2023;10:1132676. doi: 10.3389/fmed.2023.1132676.
   Web of Science ®Google Scholar
• Liu Y, Liang S, Yang F, et al. Biological characteristics of endometriotic mesenchymal stem cells isolated from ectopic lesions of patients with endometriosis. Stem Cell Res Ther. 2020;11(1):346. doi: 10.1186/s13287-020-01856-8.
   PubMed Web of Science ®Google Scholar
• Bi J, Wang D, Cui L, et al. RNA sequencing-based long non-coding RNA analysis and immunoassay in ovarian endometriosis. Am J Reprod Immunol. 2021;85(3):e13359. doi: 10.1111/aji.13359.
   PubMed Web of Science ®Google Scholar
• Shih AJ, Adelson RP, Vashistha H, et al. Single-cell analysis of menstrual endometrial tissues defines phenotypes associated with endometriosis. BMC Med. 2022;20(1):315. doi: 10.1186/s12916-022-02500-3.
   PubMed Web of Science ®Google Scholar
• Zhou W, Lian Y, Jiang J, et al. Differential expression of microRNA in exosomes derived from endometrial stromal cells of women with endometriosis-associated infertility. Reprod Biomed Online. 2020;41(2):170–181. doi: 10.1016/j.rbmo.2020.04.010.
   PubMed Web of Science ®Google Scholar
• Adamyan L, Aznaurova Y, Stepanian A, et al. Gene expression signature of endometrial samples from women with and without endometriosis. J Minim Invasive Gynecol. 2021;28(10):1774–1785. doi: 10.1016/j.jmig.2021.03.011.
   PubMed Web of Science ®Google Scholar
• Chen C-C, Chou Y-C, Hsu C-Y, et al. Transcriptome profiling of eutopic and ectopic endometrial stromal cells in women with endometriosis based on high-throughput sequencing. Biomedicines. 2022;10(10):2432. doi: 10.3390/biomedicines10102432.
   PubMed Web of Science ®Google Scholar
• Mortlock S, Kendarsari RI, Fung JN, et al. Tissue specific regulation of transcription in endometrium and association with disease. Hum Reprod. 2020;35(2):377–393. doi: 10.1093/humrep/dez279.
   PubMed Web of Science ®Google Scholar
• Shi L, Wei X, Wu B, et al. Molecular signatures correlated with poor IVF outcomes: insights from the mRNA and lncRNA expression of endometriotic granulosa cells. Front Endocrinol. 2022;13:825934. doi: 10.3389/fendo.2022.825934.
   PubMed Web of Science ®Google Scholar
• Li X, Guo L, Zhang W, et al. Identification of potential molecular mechanism related to infertile endometriosis. Front Vet Sci. 2022;9:845709. doi: 10.3389/fvets.2022.845709.
   PubMed Web of Science ®Google Scholar
• Bendifallah S, Dabi Y, Suisse S, et al. A bioinformatics approach to MicroRNA-Sequencing analysis based on human saliva samples of patients with endometriosis. Int J Mol Sci. 2022;23(14):8045. doi: 10.3390/ijms23148045.
   PubMed Web of Science ®Google Scholar
• George AF, Jang KS, Nyegaard M, et al. Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling. Hum Reprod. 2020;35(3):617–640. doi: 10.1093/humrep/deaa015.
   PubMed Web of Science ®Google Scholar
• Shan S, Yang Y, Jiang J, et al. Extracellular vesicle-derived long non-coding RNA as circulating biomarkers for endometriosis. Reprod Biomed Online. 2022;44(5):923–933. doi: 10.1016/j.rbmo.2021.11.019.
   PubMed Web of Science ®Google Scholar
• Zou G, Wang J, Xu X, et al. Cell subtypes and immune dysfunction in peritoneal fluid of endometriosis revealed by single-cell RNA-sequencing. Cell Biosci. 2021;11(1):98. doi: 10.1186/s13578-021-00613-5.
   PubMed Web of Science ®Google Scholar
• Wu R, Li J, Li J, et al. Circular RNA expression profiling and bioinformatic analysis of cumulus cells in endometriosis infertility patients. Epigenomics. 2020;12(23):2093–2108. doi: 10.2217/epi-2020-0291.
   PubMed Web of Science ®Google Scholar
• Mirza Z, Abdel-Dayem UA. Uncovering potential roles of differentially expressed genes, upstream regulators, and canonical pathways in endometriosis using an in silico genomics approach. Diagnostics. 2020;10(6):416. doi: 10.3390/diagnostics10060416.
   Web of Science ®Google Scholar
• Jiang H, Zhang X, Wu Y, et al. Bioinformatics identification and validation of biomarkers and infiltrating immune cells in endometriosis. Front Immunol. 2022;13:944683. doi: 10.3389/fimmu.2022.944683.
   PubMed Web of Science ®Google Scholar
• Wang T, Jiang R, Yao Y, et al. Identification of endometriosis-associated genes and pathways based on bioinformatic analysis. Medicine. 2021;100(27):e26530. doi: 10.1097/MD.0000000000026530.
   PubMed Web of Science ®Google Scholar
• Shruthi, Basavaradhya Sahukar, Vinodhkumar, Palani, Selvamani. Proteomics: a new perspective for cancer. Adv Biomed Res. 2016;5(1):67. doi: 10.4103/2277-9175.180636.
   PubMedGoogle Scholar
• Yu K, Xiao K, Sun Q-Q, et al. Comparative proteomic analysis of seminal plasma exosomes in buffalo with high and low sperm motility. BMC Genomics. 2023;24(1):8. doi: 10.1186/s12864-022-09106-2.
   PubMed Web of Science ®Google Scholar
• Pušić M, Klančič T, Knific T, et al. Antibody arrays identified cycle-dependent plasma biomarker candidates of peritoneal endometriosis. J Pers Med. 2022;12(6):852. doi: 10.3390/jpm12060852.
   PubMed Web of Science ®Google Scholar
• Janša V, Klančič T, Pušić M, et al. Proteomic analysis of peritoneal fluid identified COMP and TGFBI as new candidate biomarkers for endometriosis. Sci Rep. 2021;11(1):20870. doi: 10.1038/s41598-021-00299-2.
   PubMed Web of Science ®Google Scholar
• Fu X, Yao M, Ye C, et al. Osteopontin regulates endometrial stromal cell migration in endometriosis through the PI3K pathway: osteopontin regulates endometrial cell migration in endometriosis. Reprod Sci. 2021;28(2):435–446. doi: 10.1007/s43032-020-00301-8.
   PubMed Web of Science ®Google Scholar
• Laudański P, Rogalska G, Warzecha D, et al. Autoantibody screening of plasma and peritoneal fluid of patients with endometriosis. Hum Reprod. 2023;38(4):629–643. doi: 10.1093/humrep/dead011.
   PubMed Web of Science ®Google Scholar
• Neuditschko B, Leibetseder M, Brunmair J, et al. Epithelial cell line derived from endometriotic lesion mimics macrophage nervous mechanism of pain generation on proteome and metabolome levels. Biomolecules. 2021;11(8):1230. doi: 10.3390/biom11081230.
   PubMed Web of Science ®Google Scholar
• Yao Z, Zhang Y, Yan J, et al. Deciphering biomarkers of endometriosis by proteomic analysis of eutopic endometrium in infertile patients. J Gynecol Obstet Hum Reprod. 2021;50(5):102043. doi: 10.1016/j.jogoh.2020.102043.
   PubMed Web of Science ®Google Scholar
• Manousopoulou A, Hamdan M, Fotopoulos M, et al. Integrated eutopic endometrium and non-depleted serum quantitative proteomic analysis identifies candidate serological markers of endometriosis. PROTEOMICS Clin Appl. 2019;13(3):1800153.
   Web of Science ®Google Scholar
• Sasamoto N, Ngo L, Vitonis AF, et al. Circulating proteomic profiles associated with endometriosis in adolescents and young adults. Hum Reprod. 2022;37(9):2042–2053. doi: 10.1093/humrep/deac146.
   PubMed Web of Science ®Google Scholar
• Nazri HM, Imran M, Fischer R, et al. Characterization of exosomes in peritoneal fluid of endometriosis patients. Fertil Steril. 2020;113(2):364–373. e2. doi: 10.1016/j.fertnstert.2019.09.032.
   PubMed Web of Science ®Google Scholar
• Méar L, Com E, Fathallah K, et al. The eutopic endometrium proteome in endometriosis reveals candidate markers and molecular mechanisms of physiopathology. Diagnostics. 2022;12(2):419. doi: 10.3390/diagnostics12020419.
   Web of Science ®Google Scholar
• Sahar T, Nigam A, Anjum S, et al. Differential expression of lumican, mimecan, annexin A5 and serotransferrin in ectopic and matched eutopic endometrium in ovarian endometriosis: a case-control study. Gynecol Endocrinol. 2021;37(1):56–60. doi: 10.1080/09513590.2020.1824218.
   PubMed Web of Science ®Google Scholar
• Penariol LB, Thomé CH, Tozetti PA, et al. What do the transcriptome and proteome of menstrual blood-derived mesenchymal stem cells tell us about endometriosis? Int J Mol Sci. 2022;23(19):11515. doi: 10.3390/ijms231911515.
   PubMed Web of Science ®Google Scholar
• Prašnikar E, Knez J, Kovačič B, et al. Molecular signature of eutopic endometrium in endometriosis based on the multi-omics integrative synthesis. J Assist Reprod Genet. 2020;37(7):1593–1611. doi: 10.1007/s10815-020-01833-3.
   PubMed Web of Science ®Google Scholar
• Sasamoto N, Ngo L, Vitonis AF, et al. Plasma proteomic profiles of pain subtypes in adolescents and young adults with endometriosis. Hum Reprod. 2023;38(8):1509–1519. doi: 10.1093/humrep/dead099.
   PubMed Web of Science ®Google Scholar
• Heidari F, Mohajeri N, Zarghami N. Targeted design of green carbon dot-CA-125 aptamer conjugate for the fluorescence imaging of ovarian cancer cell. Cell Biochem Biophys. 2022;80(1):75–88. doi: 10.1007/s12013-021-01034-4.
   PubMed Web of Science ®Google Scholar
• Karadağ İ, Karakaya S, Ateş Ö, et al. CA-125/CEA ratio as a prognostic factor in type II endometrial cancer: a single institute experience. Available from: https://www.wcrj.net/wp-content/uploads/sites/5/2022/12/e2453.pdf
   Google Scholar
• Ma Y-y, Wang H, Zhao W-D, et al. Prognostic value of combined lactate dehydrogenase, C-reactive protein, cancer antigen 153 and cancer antigen 125 in metastatic breast cancer. Cancer Control. 2022;29:10732748211053150. doi: 10.1177/10732748211053150.
   Web of Science ®Google Scholar
• Wang Y, Lo T-T, Wang L, et al. Long-term efficacy and toxicity of intensity-modulated radiotherapy in bulky cervical cancer. Int J Environ Res Public Health. 2023;20(2):1161. doi: 10.3390/ijerph20021161.
   PubMed Web of Science ®Google Scholar
• Amiri MP, Khoshkam M, Salek RM, et al. Metabolomics in early detection and prognosis of acute coronary syndrome. Clin Chim Acta. 2019;495:43–53. doi: 10.1016/j.cca.2019.03.1632.
   PubMed Web of Science ®Google Scholar
• Kopylov AT, Stepanov AA, Butkova TV, et al. Consolidation of metabolomic, proteomic, and GWAS data in connective model of schizophrenia. Sci Rep. 2023;13(1):2139. doi: 10.1038/s41598-023-29117-7.
   PubMed Web of Science ®Google Scholar
• Muthubharathi BC, Gowripriya T, Balamurugan K. Metabolomics: small molecules that matter more. Mol Omics. 2021;17(2):210–229. doi: 10.1039/d0mo00176g.
   PubMed Web of Science ®Google Scholar
• Ragusa A, Svelato A. D'Avino S. Metabolomics in normal and pathologic pregnancies. New technologies and perinatal medicine. Boca Raton (FL): CRC Press; 2019. p. 133–138.
   Google Scholar
• Frank BS, Khailova L, Dekermanjian J, et al. Interstage single ventricle heart disease infants show dysregulation in multiple metabolic pathways: targeted metabolomics analysis. JACC Adv. 2023;2(1):100169.
   PubMedGoogle Scholar
• Murgia F, Angioni S, D'Alterio MN, et al. Metabolic profile of patients with severe endometriosis: a prospective experimental study. Reprod Sci. 2021;28(3):728–735. doi: 10.1007/s43032-020-00370-9.
   PubMed Web of Science ®Google Scholar
• Kusum K, Raj R, Rai S, et al. Elevated circulatory proline to glutamine ratio (PQR) in endometriosis and its potential as a diagnostic biomarker. ACS Omega. 2022;7(17):14856–14866. doi: 10.1021/acsomega.2c00332.
   PubMed Web of Science ®Google Scholar
• Loy SL, Zhou J, Cui L, et al. Discovery and validation of peritoneal endometriosis biomarkers in peritoneal fluid and serum. Reprod Biomed Online. 2021;43(4):727–737. doi: 10.1016/j.rbmo.2021.07.002.
   PubMed Web of Science ®Google Scholar
• Angioni S, Congiu F, Vitale SG, et al. Gas chromatography–mass spectrometry (GC–MS) metabolites analysis in endometriosis patients: a prospective observational translational study. J Clin Med. 2023;12(3):922. doi: 10.3390/jcm12030922.
   PubMed Web of Science ®Google Scholar
• Maignien C, Santulli P, Kateb F, et al. Endometriosis phenotypes are associated with specific serum metabolic profiles determined by proton-nuclear magnetic resonance. Reprod Biomed Online. 2020;41(4):640–652. doi: 10.1016/j.rbmo.2020.06.019.
   PubMed Web of Science ®Google Scholar
• Brinca AT, Anjos O, Alves MMC, et al. Volatilomics as an emerging strategy to determine potential biomarkers of female infertility: a pilot study. Biomedicines. 2022;10(11):2852. doi: 10.3390/biomedicines10112852.
   PubMed Web of Science ®Google Scholar
• Pocate-Cheriet K, Santulli P, Kateb F, et al. The follicular fluid metabolome differs according to the endometriosis phenotype. Reprod Biomed Online. 2020;41(6):1023–1037. doi: 10.1016/j.rbmo.2020.09.002.
   PubMed Web of Science ®Google Scholar
• Li Q, Yuan M, Jiao X, et al. Metabolite profiles in the peritoneal cavity of endometriosis patients and mouse models. Reprod Biomed Online. 2021;43(5):810–819. doi: 10.1016/j.rbmo.2021.06.029.
   PubMed Web of Science ®Google Scholar
• Turathum B, Gao E-M, Grataitong K, et al. Dysregulated sphingolipid metabolism and autophagy in granulosa cells of women with endometriosis. Front Endocrinol. 2022;13:906570. doi: 10.3389/fendo.2022.906570.
   PubMed Web of Science ®Google Scholar
• Ni Z, Sun S, Bi Y, et al. Correlation of fecal metabolomics and gut microbiota in mice with endometriosis. Am J Reprod Immunol. 2020;84(6):e13307. doi: 10.1111/aji.13307.
   PubMed Web of Science ®Google Scholar
• Tempest N, Hill C, Whelan A, et al. Symptomatology and serum nuclear magnetic resonance metabolomics; do they predict endometriosis in fertile women undergoing laparoscopic sterilisation? A prospective cross-sectional study. Reprod Sci. 2021;28(12):3480–3490. doi: 10.1007/s43032-021-00725-w.
   PubMed Web of Science ®Google Scholar
• Patangia DV, Anthony Ryan C, Dempsey E, et al. Impact of antibiotics on the human microbiome and consequences for host health. MicrobiologyOpen. 2022;11(1):e1260. doi: 10.1002/mbo3.1260.
   PubMed Web of Science ®Google Scholar
• Rajpoot M, Sharma AK, Sharma A, et al. Understanding the microbiome: emerging biomarkers for exploiting the microbiota for personalized medicine against cancer. Semin Cancer Biol. 2018;52(Pt 1):1–8. doi: 10.1016/j.semcancer.2018.02.003.
   PubMedGoogle Scholar
• Chadchan SB, Naik SK, Popli P, et al. Gut microbiota and microbiota-derived metabolites promotes endometriosis. Cell Death Discov. 2023;9(1):28. doi: 10.1038/s41420-023-01309-0.
   PubMed Web of Science ®Google Scholar
• Ata B, Yildiz S, Turkgeldi E, et al. The endobiota study: comparison of vaginal, cervical and gut microbiota between women with stage 3/4 endometriosis and healthy controls. Sci Rep. 2019;9(1):2204. doi: 10.1038/s41598-019-39700-6.
   PubMed Web of Science ®Google Scholar
• Shan J, Ni Z, Cheng W, et al. Gut microbiota imbalance and its correlations with hormone and inflammatory factors in patients with stage 3/4 endometriosis. Arch Gynecol Obstet. 2021;304(5):1363–1373. doi: 10.1007/s00404-021-06057-z.
   PubMed Web of Science ®Google Scholar
• Huang L, Liu B, Liu Z, et al. Gut microbiota exceeds cervical microbiota for early diagnosis of endometriosis. Front Cell Infect Microbiol. 2021;11:788836. doi: 10.3389/fcimb.2021.788836.
   PubMed Web of Science ®Google Scholar
• Svensson A, Brunkwall L, Roth B, et al. Associations between endometriosis and gut microbiota. Reprod Sci. 2021;28(8):2367–2377. doi: 10.1007/s43032-021-00506-5.
   PubMed Web of Science ®Google Scholar
• Oishi S, Mekaru K, Tanaka SE, et al. Microbiome analysis in women with endometriosis: does a microbiome exist in peritoneal fluid and ovarian cystic fluid? Reprod Med Biol. 2022;21(1):e12441. doi: 10.1002/rmb2.12441.
   PubMed Web of Science ®Google Scholar
• Lu F, Wei J, Zhong Y, et al. Antibiotic therapy and vaginal microbiota transplantation reduce endometriosis disease progression in female mice via NF-κB signaling pathway. Front Med. 2022;9:831115. doi: 10.3389/fmed.2022.831115.
   Web of Science ®Google Scholar
• Hernandes C, Silveira P, Rodrigues Sereia AF, et al. Microbiome profile of deep endometriosis patients: comparison of vaginal fluid, endometrium and lesion. Diagnostics. 2020;10(3):163. doi: 10.3390/diagnostics10030163.
   Web of Science ®Google Scholar
• Chao X, Liu Y, Fan Q, et al. The role of the vaginal microbiome in distinguishing female chronic pelvic pain caused by endometriosis/adenomyosis. Ann Transl Med. 2021;9(9):771–771. doi: 10.21037/atm-20-4586.
   PubMed Web of Science ®Google Scholar
• Wei W, Zhang X, Tang H, et al. Microbiota composition and distribution along the female reproductive tract of women with endometriosis. Ann Clin Microbiol Antimicrob. 2020;19(1):15. doi: 10.1186/s12941-020-00356-0.
   PubMed Web of Science ®Google Scholar
• Chen S, Gu Z, Zhang W, et al. Microbiome of the lower genital tract in Chinese women with endometriosis by 16s-rRNA sequencing technique: a pilot study. Ann Transl Med. 2020;8(21):1440–1440. doi: 10.21037/atm-20-1309.
   PubMed Web of Science ®Google Scholar
• Perrotta AR, Borrelli GM, Martins CO, et al. The vaginal microbiome as a tool to predict rASRM stage of disease in endometriosis: a pilot study. Reprod Sci. 2020;27(4):1064–1073. doi: 10.1007/s43032-019-00113-5.
   PubMed Web of Science ®Google Scholar
• Chang CY-Y, Chiang A-J, Lai M-T, et al. A more diverse cervical microbiome associates with better clinical outcomes in patients with endometriosis: a pilot study. Biomedicines. 2022;10(1):174. doi: 10.3390/biomedicines10010174.
   PubMed Web of Science ®Google Scholar
• Wessels JM, Domínguez MA, Leyland NA, et al. Endometrial microbiota is more diverse in people with endometriosis than symptomatic controls. Sci Rep. 2021;11(1):18877. doi: 10.1038/s41598-021-98380-3.
   PubMed Web of Science ®Google Scholar
• Holčapek M, Liebisch G, Ekroos K. Lipidomic analysis. Washington (DC): ACS Publications; 2018.
   Google Scholar
• Krishnamoorthy L, Mahal LK. Glycomic analysis: an array of technologies. ACS Chem Biol. 2009;4(9):715–732. doi: 10.1021/cb900103n.
   PubMed Web of Science ®Google Scholar
• Chrobak A, Sieradzka U, Sozański R, et al. Ectopic and eutopic stromal endometriotic cells have a damaged ceramide signaling pathway to apoptosis. Fertil Steril. 2009;92(6):1834–1843. doi: 10.1016/j.fertnstert.2008.09.035.
   PubMed Web of Science ®Google Scholar
• Garcia Garcia JM, Vannuzzi V, Donati C, et al. Endometriosis: cellular and molecular mechanisms leading to fibrosis. Reprod Sci. 2023;30(5):1453–1461. doi: 10.1007/s43032-022-01083-x.
   PubMed Web of Science ®Google Scholar
• Lin C, Chen Z, Wang C, et al. Research progress on biomarkers for endometriosis based on lipidomics. Zhejiang da Xue Xue Bao Yi Xue Ban = J Zhejiang Univ Med Sci. 2020;49(6):779–784.
   PubMedGoogle Scholar
• Guleken Z, Bulut H, Depciuch J, et al. Diagnosis of endometriosis using endometrioma volume and vibrational spectroscopy with multivariate methods as a noninvasive method. Spectrochim Acta A Mol Biomol Spectrosc. 2022;264:120246. doi: 10.1016/j.saa.2021.120246.
   PubMed Web of Science ®Google Scholar
• Li J, Gao Y, Guan L, et al. Discovery of phosphatidic acid, phosphatidylcholine, and phosphatidylserine as biomarkers for early diagnosis of endometriosis. Front Physiol. 2018;9:14. doi: 10.3389/fphys.2018.00014.
   PubMed Web of Science ®Google Scholar
• Chen Z, Wang C, Lin C, et al. Lipidomic alterations and PPARα activation induced by resveratrol lead to reduction in lesion size in endometriosis models. Oxid Med Cell Longevity. 2021;2021:1–21.
   Web of Science ®Google Scholar
• Molina NM, Jurado-Fasoli L, Sola-Leyva A, et al. Endometrial whole metabolome profile at the receptive phase: influence of Mediterranean diet and infertility. Front Endocrinol. 2023;14:1120988. PubMed PMID: 37152925; PubMed Central PMCID: PMCPMC10155813. eng. doi: 10.3389/fendo.2023.1120988.
   PubMed Web of Science ®Google Scholar
• Berkes E, Mužinić A, Rigo J, Jr, et al. The analysis of the human plasma N-glycome in endometriosis patients. Eur J Obstet Gynecol Reprod Biol. 2013;171(1):107–115. doi: 10.1016/j.ejogrb.2013.08.008.
   PubMed Web of Science ®Google Scholar
• Llarena NC, Richards EG, Priyadarshini A, et al. Characterizing the endometrial fluid cytokine profile in women with endometriosis. J Assist Reprod Genet. 2020;37(12):2999–3006. doi: 10.1007/s10815-020-01989-y.
   PubMed Web of Science ®Google Scholar
• Jørgensen H, Fedorcsak P, Isaacson K, et al. Endometrial cytokines in patients with and without endometriosis evaluated for infertility. Fertil Steril. 2022;117(3):629–640. doi: 10.1016/j.fertnstert.2021.11.024.
   PubMed Web of Science ®Google Scholar
• Vallvé-Juanico J, George AF, Sen S, et al. Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood. BMC Med. 2022;20(1):158. doi: 10.1186/s12916-022-02359-4.
   PubMed Web of Science ®Google Scholar
• Li L, Sun B, Sun Y. Identification of functional TF-miRNA-hub gene regulatory network associated with ovarian endometriosis. Front Genet. 2022;13:998417. doi: 10.3389/fgene.2022.998417.
   PubMed Web of Science ®Google Scholar
• Bao C, Wang H, Fang H. Genomic evidence supports the recognition of endometriosis as an inflammatory systemic disease and reveals disease-specific therapeutic potentials of targeting neutrophil degranulation. Front Immunol. 2022;13:758440. doi: 10.3389/fimmu.2022.758440.
   PubMed Web of Science ®Google Scholar
• Szukiewicz D. Epigenetic regulation and T-cell responses in endometriosis–something other than autoimmunity. Front Immunol. 2022;13:943839. doi: 10.3389/fimmu.2022.943839.
   PubMed Web of Science ®Google Scholar
• Ponomarenko I, Reshetnikov E, Polonikov A, et al. Candidate genes for age at menarche are associated with endometriosis. Reprod Biomed Online. 2020;41(5):943–956. doi: 10.1016/j.rbmo.2020.04.016.
   PubMed Web of Science ®Google Scholar
• Li B, Wang S, Duan H, et al. Discovery of gene module acting on ubiquitin-mediated proteolysis pathway by co-expression network analysis for endometriosis. Reprod Biomed Online. 2021;42(2):429–441. doi: 10.1016/j.rbmo.2020.10.005.
   PubMed Web of Science ®Google Scholar
• Chi R-P, Wang T, Huang C-L, et al. WNK1 regulates uterine homeostasis and its ability to support pregnancy. JCI Insight. 2020;5(22):e141832. doi: 10.1172/jci.insight.141832.
   PubMed Web of Science ®Google Scholar
• Peng X, Xia Y, Xie J, et al. Mechanism of thunberg fritillaria in treating endometriosis based on network pharmacology and the effect of peiminine on the MEK/ERK pathway. Am J Transl Res. 2022;14(9):6196.
   PubMed Web of Science ®Google Scholar
• Zhu J, Xue X, He Z, et al. Using network pharmacology and molecular docking to explore the underlying anti-inflammatory mechanism of Wuyao-Danshen to treat endometriosis. Ann Transl Med. 2022;10(4):198. doi: 10.21037/atm-22-419.
   PubMed Web of Science ®Google Scholar
• Zheng W, Wang J, Wu J, et al. Exploration of the modulatory property mechanism of ELeng capsule in the treatment of endometriosis using transcriptomics combined with systems network pharmacology. Front Pharmacol. 2021;12:674874. doi: 10.3389/fphar.2021.674874.
   PubMed Web of Science ®Google Scholar
• Lin Z, Fan W, Yu X, et al. Research into the mechanism of intervention of SanQi in endometriosis based on network pharmacology and molecular docking technology. Medicine. 2022;101(37):e30021. doi: 10.1097/MD.0000000000030021.
   PubMed Web of Science ®Google Scholar
• Guo R, Yi Z, Wang Y, et al. Network pharmacology and experimental validation to explore the potential mechanism of Sanjie Zhentong capsule in endometriosis treatment. Front Endocrinol. 2023;14:1110995. doi: 10.3389/fendo.2023.1110995.
   PubMed Web of Science ®Google Scholar
• Liu Y-N, Hu X-J, Liu B, et al. Network pharmacology-based prediction of bioactive compounds and potential targets of Wenjing decoction for treatment of endometriosis. Evid Based Complement Alternat Med. 2021;2021:1–12. doi: 10.1155/2021/4521843.
   Web of Science ®Google Scholar
• Zheng W, Wu J, Gu J, et al. Modular characteristics and mechanism of action of herbs for endometriosis treatment in Chinese medicine: a data mining and network pharmacology–based identification. Front Pharmacol. 2020;11:147. doi: 10.3389/fphar.2020.00147.
   PubMed Web of Science ®Google Scholar