Acidosis and Tissue Hypoxia in the Critically III: How to Measure it and What Does it Mean

References

• Torres J, Darley-Usmar V Wilson MT. Inhibition of cytochrome c oxidase in turnover by nitric oxide: mechanism and implications for control of respiration. Biochem J 1995; 312: 169–73.
   PubMed Web of Science ®Google Scholar
• Adrogue HJ and Madias NE. Medical progress: management of life threatening acid base disorders. N Engl J Med 1998; 338: 107–11.
   PubMed Web of Science ®Google Scholar
• Fiddian-Green 1993 Fiddian-Green RG, Haglund U, Gutierrez G, et al. Goals for the resuscitation of shock. Crit Care Med 1993; 21: S25–S31.
   Google Scholar
• Hayes MA, Timmins AC, Yau EH, et al. Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med 1994; 330: 1717–22.
   PubMed Web of Science ®Google Scholar
• Myers PR, Zhong Q, Jones JJ, et al. Release of EDRF and NO in ex vivo perfused aorta: inhibition by in vivo E. coli endotoxemia. Am J Physiol 1995; 268: H955–H961.
   PubMed Web of Science ®Google Scholar
• Parker JL, Keller RS, DeFily DV, et al. Coronary vascular smooth muscle function in endotoxemia in dogs. Am J Physiol 1991; 260: H832–H842.
   Google Scholar
• Schumaker PT, Kazaglis J, Connolly HV, et al. Systemic and gut oxygen extraction during endotoxemia: role of nitric oxide synthesis. Am Rev Resp Crit Care Med 1995; 151: 107–15.
   Google Scholar
• Umans JG, Wylam ME, Samsel RW, et al. Effects of endotoxin in vivo on endothelial and smooth muscle cell function in rabbit and rat aorta. Am Rev Resp Dis 1993; 148: 1638–45.
   Google Scholar
• Boczkowski J, Vicaut E, Aubier M. In vivo effects of E. coli sepsis in unanesthetized rats. J Appl Physiol 1992; 72: 2219–24.
   Google Scholar
• Lam C, Tymal K, Martin C, et al. Microvascular perfusion is impaired in a rat model of normotensive sepsis. J Clin Invest 1994; 94: 2077–83.
   PubMed Web of Science ®Google Scholar
• Gilmour DG, Aitkenhead AR, Hothershall AP, et al. The effect of hypovolaemia on colon blood flow in the dog. Br J Surg 1980; 67: 82–4.
   Google Scholar
• Takala J and Ruokonen E. Blood flow and oxygen transport in septic shock. Clin Intensive Care 1992; 3(Suppl): 24–7.
   Google Scholar
• Gottlieb ME, Sarfeh IJ, Stratton H, et al. Hepatic perfusion and splanchnic oxygen consumption in patients post injury. J Trauma 1983; 23: 836–43.
   PubMed Web of Science ®Google Scholar
• Lillehei RC. The intestinal factor in irreversible hemorrhagic shock. Surgery 1957; 42: 1043–53.
   PubMed Web of Science ®Google Scholar
• Rush PF, Sori AJ, Murphy TF, et al. Endotoxemia and bacteremia during hemorrhagic shock. Ann Surg 1988; 207: 549–54.
   PubMed Web of Science ®Google Scholar
• Ziegler TR, Smith RJ, O’Dwyer ST, et al. Increased intestinal permeability associated with an infection in burn patients. Arch Surg 1988; 123: 1313–9.
   PubMed Web of Science ®Google Scholar
• Roumen RMH, Hendriks T Goris RJA. Intestinal permeability after severe trauma and haemorrhagic shock is increased without relation to septic complications. Intensive Care Med 1992; 18(Suppl 2)</b>: S75.
   Google Scholar
• Poggetti RS, Moore FA, Moore EE, et al. Simultaneous liver and lung injury following gut ischemia is mediated by xanthine oxidase. J Trauma 1992; 32: 723–8.
   PubMedGoogle Scholar
• Galley HF, Davies MJ Webster NR. Xanthine oxidase activity and free radical generation in patients with sepsis syndrome. Crit Care Med 1996; 24: 1649–53.
   PubMed Web of Science ®Google Scholar
• Gelman SI. Disturbances in hepatic blood flow during anesthesia and surgery. Arch Surg 1976; 111: 851–83.
   Google Scholar
• Dahn MS, Lange P, Lobdell K, et al. Splanchnic and total body oxygen consumption differences in septic and injured patients. Surgery 1987; 101: 69–80.
   PubMed Web of Science ®Google Scholar
• Grum CM, Fiddian-Green RG, Pittenger GL, et al. Adequacy of tissue oxygenation in intact dog intestine. J Appl Physiol 1984; 56: 1065–9.
   PubMed Web of Science ®Google Scholar
• Nelson DP, King CE, Dodd SL, et al. Systemic and intestinal limits of O2 extraction in the dog. J Appl Physiol 1987; 63: 387–94.
   PubMed Web of Science ®Google Scholar
• Riddington D, Venkatesh B, Clutton-Brock T, et al. Measuring carbon dioxide tension in saline and alternative solutions: quantification of bias and precision in two blood gas analyzers. Crit Care Med 1994; 22: 96–100.
   Google Scholar
• Takala J, Parviainan I, Siloaho M, et al. Saline PCO2 is an important source of error in the assessment of gastric intramucosal pH. Crit Care Med 1994; 22: 1877–9.
   Google Scholar
• Rhodes A, Boyd O, Bland JM, et al. Routine blood-gas analysis and gastric tonometry: a reappraisal. Lancet 1997; 350: 413–4.
   Google Scholar
• Gutierrez G and Brown SD. Gastrointestinal tonometry: a monitor of regional dysoxia. New Horizons 1996; 4: 413–9.
   PubMedGoogle Scholar
• Cunningham JA, Cousar CD, Jaffin JH, et al. Extraluminal and intraluminal PCO2 levels in the ischaemic intestines of rats. Curr Surg 1897; 44: 229–32.
   Google Scholar
• Fiddian-Green RG, McGough E, Pittenger G, et al. Predictive value of intramural pH and other risk factors for massive bleeding from stress ulceration. Gastroenterol 1983; 85: 613–20.
   PubMed Web of Science ®Google Scholar
• Friedman G, Berlot G, Kahn RJ, et al. Combined measurements of blood lactate concentrations and gastrc intramucosal pH in patients with severe sepsis. Crit Care Med 1995; 23: 1184–93.
   PubMed Web of Science ®Google Scholar
• Boyd O, Mackay CJ, Lamb G, et al. Comparison of clinical information gained from routine blood-gas analysis and from gsatric tonometry for intramural pH. Lancet 1993; 341: 142–4.
   PubMed Web of Science ®Google Scholar
• Schlichting E and Lyberg T. Routine blood-gas analysis and gastric tonometry for intramural pH. Lancet 1993; 341: 692.
   Google Scholar
• Mythen MG, Salmon JB Webb AR. Routine blood-gas analysis and gastric tonometry for intramural pH. Lancet 1993; 341: 692–3.
   Google Scholar
• Trinder TJ, Levery GG, Fee JPH, et al. Low gastric intramucosal pH: incidence and significance in intensive care patients. Anaesth Intens Care 1995; 23: 315–21.
   Google Scholar
• Joynt GM, Lipman J, Gomersall CD, et al. Gastric intramucosal pH and blood lactate in severe sepsis. Anaesthesia 1997; 52: 726–32.
   Google Scholar
• Maynard N, Bihari D, Beale R, et al. Assessment of splanchnic oxygenation by gastric tonometry in patients with acute circulatory failure. JAMA 1993; 270: 1203–10.
   PubMed Web of Science ®Google Scholar
• Deleted in proof.
   Google Scholar
• Meier-Hellmann A and Specht M, Hannemann L, et al. Splanchnic blood flow is greater in septic shock treated with norepinephrine than in severe sepsis. Intensive Care Med 1996; 22: 1354–9.
   Google Scholar
• Fink MP, Kaups KL, Wang H, et al. Maintenance of superior mesenteric arterial perfusion prevents increased intestinal permeability in endotoxic pigs. Surgery 1991; 110: 154–61.
   PubMed Web of Science ®Google Scholar
• Antonsson JB, Engstom L, Rasmussen I, et al. Changes in gut intramucosal pH and gut oxygen extraction ratio in a porcine model of peritonitis and hemorrhage. Crit Care Med 1995; 23: 1872–81.
   Google Scholar
• Rosser DM, Stidwill RP, Jacobson D, et al. Oxygen tension in the bladder epithelium rises in both high and low cardiac output endotoxemic sepsis. J Appl Physiol 1995; 79: 1878–82.
   PubMedGoogle Scholar
• Bellomo R, Kellum JA, Pinsky MR. Transvisceral lactate fluxes during early endotoxemia. Chest 1996; 110: 198–204
   Google Scholar
• Van der Meer TJ, Wang H Fink MP. Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock. Crit Care Med 1995; 23: 1217–26.
   Google Scholar
• Hurtado FJ, Gutierrez AM, Silva N, et al. Role of tissue hypoxia as the mechanism of lactic acidosis during E coli endotoxemia. J Appl Physiol 1992; 72: 1895–1901.
   Google Scholar
• Gutierrez G, Clark C, Brown SD, et al. Effect of dobutamine on oxygen consumption and gastric mucosal pH in septic patients. Am J Resp Crit Care Med 1994; 150: 324–9.
   PubMed Web of Science ®Google Scholar
• Trinder TJ, Lavery GG, Fee JPH, et al. Correction of splanchnic oxygen defecit in the intensive care unit: dopeximine nad colloid versusu placebo. Anaesth Intens Care 1995; 23: 178–82.
   Google Scholar
• Silverman HJ and Tuma P. Gastric tonometry in patients with sepsis, effect of dobutamine infusions and packed red cell transfusions. Chest 1992; 102: 184–8.
   PubMed Web of Science ®Google Scholar
• Braga M, Gianotti L, Cestari A, et al. Gut function, immune and inflammatory responses in patients fed perioperatively with supplemented formulas. Arch Surg 1996; 131: 1257–65.
   Google Scholar
• Gore DC, Jahoor F, Hibbert JM, et al. Lactic acidosis during sepsis is related to increased pyruvate production, not deficits in tissue oxygen availability. Ann Surg 1996; 224: 97–102.
   PubMed Web of Science ®Google Scholar
• Kellum JA, Kramer KJ, Lee K, et al. Release of lactate by the lung in acute lung injury. Chest 1997; 111: 1301–5.
   Google Scholar
• Douzinas EE, Tsidemiadou PD, Pitaridis MT, et al. The regional production of cytokines and lactate in sepsis-related multiple organ failure. Am J Resp Crit Care Med 1997; 155: 53–9.
   PubMed Web of Science ®Google Scholar
• Curtis SE and Cain SM. Regional and systemic oxygen delivery/uptake relations and lactate flux in hyperdynamic endotoxin treated dogs. Am Rev Respir Dis 1992; 145: 348–54.
   Google Scholar
• Gutierrez G, Lund N Palizas F. Rabbit skeletal muscle PO2 during hypodynamic sepsis. Chest 1991; 99: 224–9.
   PubMed Web of Science ®Google Scholar
• Astiz M, Rackow EC, Weil MH, et al. Early impairment of oxidative metabolism and energy production in severe sepsis. Circ Shock 1988; 26: 311–20.
   Google Scholar
• Reinhardt K, Bloos F, Konig F, et al. Oxygen tranbsport variables and mucsle tissue oxygenation in critically ill patients with and without sepsis. Adv Exp Med Biol 1990; 277: 861–4.
   Google Scholar
• Boekstegers P, Weidenhofer S, Kapsner T, et al. Skeletal muscle partial pressure of oxygen in patients with sepsis. Crit Care Med 1994: 22: 640–50.
   Google Scholar
• Naumann CP, Ruetsch YA, Fleckenstein W, et al. PO2 profiles in human muscle tissue as indicator of therapeutic effect in septic shock patients. Adv Exp Med Biol 1992; 317: 869–77.
   Google Scholar
• Wilson DF, Gomi S, Pastuszko A, et al. Oxygenation of the cortext of the brain of cats during occlusion of the middle cerebral artery and reperfusion. Adv Exp Med Biol 1992; 3317: 689–94.
   Google Scholar
• Elwell CE, Cope M, Edwards AD, et al. Measurements of cerebral blood flow in adult humans using near infra-red spectroscopy — methodology and possible errors. Adv Exp Med Biol 1992; 317: 235–45.
   PubMedGoogle Scholar
• Liu KJ, Bacic G, Hoopes PJ, et al. Assessment of cerebral PO2 by EPR oximetry in rodents: effects of anesthesia, ischemia, and breathing gas. Brain Res 1995; 685: 91–8.
   PubMedGoogle Scholar
• Adrogue HJ and Madias NE. Medical progress: management of life-threatening acid-base disorders: first of two parts. N Engl J Med 1998; 338: 26–34.
   PubMed Web of Science ®Google Scholar
• Adrogue HJ and Madias NE. Medical progress: management of life-threatening acid-base disorders: second of two parts. N Engl J Med 1998; 338: 107–11.
   PubMed Web of Science ®Google Scholar
• Fink MP. Does tissue acidosis in sepsis indicate tissue hypoperfusion? Intensive Care Med1996; 22: 1114–46.
   Google Scholar
• Kilpatrick-Smith L, Dean J, Erecinska M, et al. Cellular effects of endotoxin in vitro. II Reversibility of endotoxic damage. Circ Shock 1983; 11: 101–11.
   Google Scholar