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Research Article

Physiological Roles of the Leptin Endocrine System: Differences between Mice and Humans

Pages 575-655 | Published online: 29 Sep 2008

References

  • Friedman JM. Leptin, leptin receptors, and the control of body weight. Nutr Rev 1998; 56: S38–S46.
  • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998; 395: 763–770.
  • Tartaglia LA. The leptin receptor. J Biol Chem 1997; 272: 6093–6096.
  • Flier JS. What’s in a name? In search of leptin’s physiologic role. J Clin Endocrinol Metab 1998; 83: 1407–1413.
  • Coleman DL. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 1978; 14: 141–148.
  • Campfield LA, Smith FJ. Overview: neurobiology of OB protein (leptin). Proc Nutr Soc 1998; 57: 429–440.
  • Campfield LA, Smith FJ Burn P. OB protein: a hormonal controller of central neural networks mediating behavioral, metabolic and neuroendocrine responses. Endocrinol Metab 1997; 4: 81–102.
  • Stephens TW, Caro JF. To be lean or not to be lean. Is leptin the answer. Exp Clin Endocrinol Diabetes 1998; 106: 1–15.
  • Considine RV, Caro JF. Leptin and the regulation of body weight. Int J Biochem Cell Biol 1997; 11: 1255–1272.
  • Trayhurn P, Duncan JS, Hoggard N, et al. Regulation of leptin production: a dominant role for the sympathetic nervous system. Proc Nutr Soc 1998; 57: 413–419.
  • Trayhurn P, Hoggard N, Mercer JG, et al. Leptin: fundamental aspects. Int J Obesity 1999; 23: suppl 1, 22–28.
  • Jéquier E, Tappy L. Regulation of body weight in humans. Physiol Rev 1999; 79: 451–480.
  • Caro JF, Sinha MK, Kolaczynski JW, et al. Leptin: the tale of an obesity gene. Diabetes 1996; 45: 1455–1462.
  • Tritos NA, Mantzoros CS. Leptin: its role in obesity and beyond. Diabetologia 1997; 40: 1371–1379.
  • Frübeck G, Jebb SA Prentice AM. Leptin: physiology and pathophysiology. Clin Physiol 1998; 18: 399–419.
  • Mantzoros CS, Moschos SJ. Leptin: in search of role(s) in human physiology and patho-physiology. Clin Endocrinol 1998; 49: 551–567.
  • Bjørbœk C, Uotani S, da Silva B, et al. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997; 272: 32686–32695.
  • Uotani S, Bjørbæk C, Tornøe J, et al. Functional properties of leptin receptor isoforms. Internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes 1999; 48: 279–286.
  • Mantzoros CS. Leptin and the hypothalamus; neuroendocrine regulation of food intake. Mol Psychiatry 1999; 4: 8–12.
  • Mantzoros CS. The role of leptin in human obesity and disease: a review of current evidence. Ann Intern Med 1999; 130: 671–680.
  • Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387: 903–908.
  • Farooqi S, Rau H, Whitehead J, O’Rahilly S. ob gene mutations and obesity. Proc Nutr Soc 1998; 57: 471–475.
  • O’Rahilly S. Life without leptin. Nature 1998; 330–331.
  • Strobel A, Issad T, Camoin L, et al. A leptin missense mutation associated with hypogo-nadism and morbid obesity. Nat Genet 1998; 18: 213–215.
  • Rau H, Reaves BJ, O’Rahilly S, et al. Truncated human leptin (D133) associated with extreme obesity undergoes proteasomal degradation after defective intracellular transport. Endocrinology 1999; 140: 1718–1723.
  • Clément K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998; 392:398-401.
  • Clément K. Leptin and the genetics of obesity. Acta Paediatr 1999; Suppl 428: 51–57.
  • Bronson FH. Mammalian reproduction: an ecological perspective. Biol Reprod 1985; 32: 1–26.
  • Hamilton GD, Bronson FH. Food restriction and reproductive development: male and female mice and male rats. Am J Physiol 1986; 250: R370–R376.
  • Stehling O, Döring H, Ertl J, et al. Leptin reduces juvenile fat stores by altering the circadian cycle of energy expenditure. Am J Physiol 1996; 271: R1770–R1774.
  • Döhring H, Schwarzer K, Nuesslein-Hildesheim B, et al. Leptin selectively increases energy expenditure of food-restricted lean mice. Int J Obesity 1998; 22: 83–88.
  • Hwa JJ, Fawzi AB, Graziano MP, et al. Leptin increases energy expenditure and selectively promotes fat metabolism in ob/ob mice. Am J Physiol 1997; 272: R1204–R1209.
  • Halaas JL, Boozer C, Blair-West J, et al. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA 1997; 94: 8878–8883.
  • Ewart-Toland A, Mounzih K, Qui J, et al. Effect of the genetic background on the reproduction of leptin-deficient obese mice. Endocrinology 1999; 140: 732–738.
  • Hamilton GD, Bronson FH. Food restriction and reproductive development in wild house mice. Biol Reprod 1985; 32: 773–778.
  • D’Adamo M, Buongiorno A, Maroccia E, et al. Increased OB gene expression leads to elevated plasma leptin concentrations in patients with chronic primary hyperinsulinemia. Diabetes 1998; 47: 1625–1629.
  • Kolaczynski JW, Nyce MR, Considine RV, et al. Acute and chronic effect of insulin on leptin production in humans. Diabetes 1996; 45: 699–701.
  • Pratley RE, Nicolson M, Bogardus C, et al. Plasma leptin responses to fasting in Pima Indians. Am J Physiol 1997; 273: E644–E649.
  • Schoeller DA, Cella LK, Sinha MK, et al. Entrainment of the diurnal rhythm of plasma leptin to meal timing. J Clin Invest 1997; 100: 1882–1887.
  • Van Aggel-Leijssen DPC, van Baak MA, Tenenbaum R, et al. Regulation of average 24h human plasma leptin level; the influence of exercise and physiological changes in energy balance. Int J Obesity 1999; 23: 151–158.
  • Licinio J, Mantzoros C, Negrão AB, et al. Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat Med 1997; 3: 575–579.
  • Licinio J, Negrão AB, Mantzoros C, et al. Sex differences in circulating human leptin pulse amplitude: clinical implications. J Clin Endocrinol Metab 1998; 83: 4140–4147.
  • Licinio J, Negrão AB, Mantzoros C, et al. Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women. Proc Natl Acad Sci USA 1998; 95: 2541–2546.
  • Popovic V, Micic D, Danjanovic S, et al. Serum leptin and insulin concentrations in patients with insulinoma before and after surgery. Eur J Endocrinol 1998; 138: 86–88.
  • Coppack SW, Pinkney JH Mohamed-Ali V. Leptin production in human adipose tissue. Proc Nutr Soc 1998; 57: 461–470.
  • Esler M, Vaz M, Collier G, et al. Leptin in human plasma is derived in part from the brain, and cleared by the kidneys. Lancet 1998; 351: 879.
  • Garibotto G, Russo R, Franceschini R, et al. Inter-organ leptin exchange in humans. Biochem Biophys Res Commun 1998; 247: 504–509.
  • Laharrague P, Larrouy D, Fontanilles A-M, et al. High expression of leptin by human bone marrow adipocytes in primary culture. FASEB J 1998; 12: 747–752.
  • Bado A, Levasseur S, Attoub S, et al. The stomach is a source of leptin. Nature 1998; 394: 790–793.
  • Señaris R, Garcia-Caballero T, Casabiell X, et al. Synthesis of leptin in human placenta. Endocrinology 1997; 138: 4501–4504.
  • Hassink, SG, de Lancey E, Sheslow DV, et al. Placental leptin: an important new growth factor in intrauterine and neonatal development? Pediatrics 1997; 100: e1. (http:// www.pediatrics.org/cgi/contents/full/100/1/e1).
  • Masuzaki H, Ogawa Y, Sagawa N, et al. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 1997; 3: 1029–1033.
  • Lepercq J, Cauzac M, Lahlou N, et al. Overexpression of placental leptin in diabetic pregnancy. A critical role for insulin. Diabetes 1998; 47: 847–850.
  • Yura S, Sagawa N, Mise H, et al. A positive umbilical venous-arterial difference of leptin level and its rapid decline after birth. Am J Obstet Gynecol 1998; 178: 926–930.
  • Cioffi JA, Van Blerkom J, Antczak M, et al. The expression of leptin and its receptors in pre-ovulatory human follicles. Mol Hum Reprod 1997; 3: 467–472.
  • Smith-Kirwin SM, O’Connor DM, Johnston J, et al. Leptin expression in human mammary epithelial cells and breast milk. J Clin Endocrinol Metab 1998; 83: 1810–1813
  • Casabiell X, Piñeiro V, Tomé MA, et al. Presence of leptin in colostrum and/or breast milk from lactating mothers: a potential role in the regulation of neonatal food intake. J Clin Endocrinol Metab 1997; 82: 4270–4273.
  • Houseknecht KL, McGuire MK, Portocarrero CP, et al. Leptin is present in human milk and is related to maternal plasma leptin concentration and adiposity. Biochem Biophys Res Commun 1997; 240: 742–747.
  • Henriksen JH, Holst JJ, Møller S, et al. Increased circulating leptin in alcoholic cirrhosis: relation to release and disposal. Hepatology 1999; 29: 1818–1824.
  • Potter JJ, Womack L, Mezey E, et al. Transdifferentiation of rat hepatic stellate cells results in leptin expression. Biochem Biophys Res Commun 1998; 244: 178–182.
  • McCullough AJ, Bugianesi E, Marchesini G, et al. Gender-dependent alterations in serum leptin in alcoholic cirrhosis. Gastroenterology 1998; 115: 947–953.
  • Kaplan LM. Leptin, obesity and liver disease. Gastroenterology 1998; 115: 997–1001.
  • Dulor J-P, Cambon B, Vigneron P, et al. Expression of specific white adipose tissue genes in denervation-induced skeletal muscle fatty degeneration. FEBS Lett 1998; 439: 89–92.
  • Li H-Y, Wang L-L Yeh R-S. Leptin immunoreactivity in the central nervous system in normal and diabetic rats. Neuroreport 1999; 10: 437–442.
  • Klein S, Coppack SW, Mohamed-Ali V, et al. Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes 1996; 45: 984–987.
  • Cumin F, Baum H-P Levens N. Leptin is cleared from the circulation primarily by the kidney. Int J Obesity 1996; 20: 1120–1126.
  • Zeng J, Patterson BW, Klein S, et al. Whole body leptin kinetics and renal metabolism in vivo. Am J Physiol 1997; 273: E1102–E1106.
  • Vila R, Adan C, Rafecas I, et al. Plasma leptin turnover rates in lean and obese Zucker rats. Endocrinology 1998; 139: 4466–4469.
  • Hill RA, Margetic S, Pegg GG, et al. Leptin: its pharmacokinetics and tissue distribution. Int J Obesity 1998; 22: 765–770.
  • Ahima RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996; 382: 250–252.
  • Harris RBS, Zhou J, Weigle DS, et al. Recombinant leptin exchanges between parabiosed mice but does not reach equilibrium. Am J Physiol 1997; 272: R1800–R1808.
  • Van Heek M, Compton DS, France CF, et al. Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest 1997; 99: 385–390.
  • Mantzoros CS, Frederich RC, Qu D, et al. Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypo-thalamic neuropeptide Y and circulating corticosterone concentrations. Diabetes 1998; 47: 230–238.
  • Jensen MD, Møller N, Nair KS, et al. Regional leptin kinetics in humans. Am J Clin Nutr 1999; 69: 18–21.
  • Cumin F, Baum H-P Levens N. Mechanism of leptin removal from the circulation by the kidney. J Endocrinol 1997; 155: 577–585.
  • Meyer C, Robson D, Rackovsky N, et al. Role of the kidney in human leptin metabolism. Am J Physiol 1997; 273: E903–E907.
  • Kennedy A, Gettys TW, Watson P, et al. The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure. J Clin Endocrinol Metab 1997; 82: 1293–1300.
  • Hickey MS, Israel RG, Gardiner SN, et al. Gender differences in serum leptin levels in humans. Biochem Mol Med 1996; 59: 1–6.
  • Hickey MS, Houmard JA, Considine RV, et al. Gender-dependent effects of exercise training on serum leptin levels in humans. Am J Physiol 1997; 272: E562–E566.
  • Hickey MS, Gardiner SN, Thomson DP, et al. Gender differences in plasma leptin concentration are not influenced by menopause or hormone replacement therapy. Med Sci Res 1998; 26: 271–273.
  • Saad MG, Damani S, Gingerich RL, et al. Sexual dimorphism in plasma leptin concentration. J Clin Endocrinol Metab 1997; 82: 579–584.
  • Lönnqvist F, Wennlund A Arner P. Relationship between circulating leptin and peripheral fat distribution in obese subjects. Int J Obesity 1997; 21: 255–260.
  • Lönnqvist F, Nordfors L, Jansson M, et al. Leptin secretion from adipose tissue in women. Relationship to plasma levels and gene expression. J Clin Invest 1997; 99: 2398–2404.
  • Bennett FI, McFarlane-Anderson N, Wilks R, et al. Leptin concentration in women is influenced by regional distribution of adipose tissue. Am J Clin Nutr 1997; 66: 1340–1344.
  • Jensen MD, Hensrud D, O’Brien PC, et al. Collection and interpretaion of plasma leptin concentration data in humans. Obesity Res 1999; 7: 241–245.
  • Van Harmelen V, Reynisdottir S, Eriksson P, et al. Leptin secretion from subcutaneous and visceral adipose tissue in women. Diabetes 1998; 47: 913–917.
  • Montague CT, Prins JB, Sanders L, et al. Depot- and sex-specific differences in human leptin mRNA expression. Implications for the control of regional fat distribution. Diabetes 1997; 46: 342–347.
  • Hardie L, Trayhurn P, Abramovich D, et al. Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clin Endocrinol 1997; 47: 101–106.
  • Messinis IE, Milingos S, Zikopoulos K, et al. Leptin concentrations in the follicular phase of spontaneous cycles and cycles superovulated with follicle stimulating hormone. Hum Reprod 1998; 13: 1152–1156.
  • Messinis IE, Milingos SD, Alexandris E, et al. Leptin concentrations in normal women following bilateral ovariectomy. Hum Reprod 1999; 14: 913–918.
  • Riad-Gabriel MG, Jinagouda SD, Sharma A, et al. Changes in plasma leptin during the menstrual cycle. Eur J Endocrinol 1998; 139: 528–531.
  • Quinton ND, Laird SM, Okon MA, et al. Serum leptin levels during the menstrual cycle of healthy fertile women. Br J Biomed Sci 1999; 56: 16–19.
  • Paolisso G, Rizzo MR, Mone CM, et al. Plasma sex hormones are significantly associated with plasma leptin concentration in healthy subjects. Clin Endocrinol 1998; 48: 291–297.
  • Luukkaa V, Pesonen U, Huhtaniemi I, et al. Inverse correlation between serum testosterone and leptin in men. J Clin Endocrinol Metab 1998; 83: 3243–3246.
  • Nyström F, Ekman B, Österlund M, et al. Serum leptin concentrations in a normal population and in GH deficiency: negative correlation with testosterone in men and effects of GH treatment. Clin Endocrinol 1997; 47: 191–198.
  • Jockenhövel F, Blum WF, Vogel E, et al. Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men. J Clin Endocrinol Metab 1997; 82: 2510–2513.
  • Behre HM, Simoni M Nieschlag E. Strong association between serum levels of leptin and testosterone in men. Clin Endocrinol 1997; 47: 237–240.
  • Palmert MR, Radovick S Boepple PA. The impact of reversible gonadal sex steroid suppression on serum leptin concentrations in children with central precocious puberty. J Clin Endocrinol Metab 1998; 83: 1091–1096.
  • Baumgartner RN, Waters DL, Morley JE, et al. Age-related changes in sex hormones affect the sex difference in serum leptin independently of changes in body fat. Metabolism 1999; 48: 378–384.
  • Rosenbaum M, Nicolson M, Hirsch J, et al. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 1996; 81: 3424–3427.
  • Lahlou N, Landais P, De Boissieu D, et al. Circulating leptin in normal children and during the dynamic phase of juvenile obesity. Relation to body fatness, energy metabolism, caloric intake, and sexual dimorphism. Diabetes 1997; 46: 989–993.
  • Pombo M, Herrera-Justiniano E, Considine RV, et al. Nocturnal rise of leptin in normal prepubertal and pubertal children and in patients with perinatal stalk-transection syndrome. J Clin Endocrinol Metab 1997; 82: 2751–2754.
  • Kiess W, Siebler T, Englaro P, et al. Leptin as a metabolic regulator during fetal and neonatal life and in childhood and adolescence. J Pediat Endocrinol Metab 1998; 11: 483–496.
  • Hassink SG, Sheslow DV, de Lancey E, et al. Serum leptin in children with obesity: relationship to gender and development. Pediatrics 1996; 98: 201–203.
  • Hytinantti T, Koistinen HA, Koivisto VA, et al. Changes in leptin concentration during the early postnatal period: adjustment to extrauterine life? Pediatr Res 1999; 45: 197–201.
  • Helland IB, Reseland JE, Saugstad OD, et al. Leptin levels in pregnant women and newborn infants: gender differences and reduction during the neonatal period. Pediatrics 1998; 101: e12. (http://www.pediatrics.org/cgi/content/full/101/3/e12)
  • Harigaya A, Onigata K, Nako Y, et al. Role of serum leptin in the regulation of weight gain in early infancy. Biol Neonate 1999; 75: 234–238.
  • Chung WK, Belfi K, Chua M, et al. Heterozygosity for Lepob or Leprdb affects body composition and leptin homeostasis in adult mice. Am J Physiol 1998; 274: R985–R990.
  • Ioffe E, Moon B, Connolly E, et al. Abnormal regulation of the leptin gene in the pathogenesis of obesity. Proc Natl Acad Sci USA 1998; 95: 11852–11857.
  • Matkovic V, Ilich JZ, Badenhop NE, et al. Gain in body fat is inversely related to the nocturnal rise in serum leptin level in young females. J Clin Endocrinol Metab 1997; 82: 1368–1372.
  • Kousta E, Chrisoulidou A, Lawrence NJ, et al. The circadian rhythm of leptin is preserved in growth hormone deficient hypopituitary adults. Clin Endocrinol 1998; 48: 685–690.
  • Saad MF, Riad-Gabriel MG, Khan A, et al. Diurnal and ultradian rhythmicity of plasma leptin: effects of gender and adiposity. J Clin Endocrinol Metab 1998; 83: 453–459.
  • Sinha MK, Ohannesian JP, Heiman ML, et al. Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. J Clin Invest 1996; 97: 1344–1347.
  • Langendonk JG, Pijl H, Toornvliet AC, et al. Circadian rhythm of plasma leptin levels in upper and lower body obese women: influence of body fat distribution and weight loss. J Clin Endocrinol Metab 1998; 83: 1706–1712.
  • Herpertz S, Wagner R, Albers N, et al. Circadian plasma leptin levels in patients with anorexia nervosa: relation to insulin and cortisol. Horm Res 1998; 50: 197–204.
  • Taylor AE, Hubbard J Anderson EJ. Impact of binge eating on metabolic and leptin dynamics in normal young women. J Clin Endocrinol Metab 1999; 84: 428–434.
  • Dallongeville J, Hecquet B, Lebel P, et al. Short term response of circulating leptin to feeding and fasting in man: influence of circadian cycle. Int J Obesity 1998; 22: 728–733.
  • Balligand JL, Brichard SM, Brichard V, et al. Hypoleptinemia in patients with anorexia nervosa: loss of circadian rhythm and unresponsiveness to short-term refeeding. Eur J Endocrinol 1998; 138: 415–420.
  • Simon C, Gronfier C, Schlienger JL, et al. Circadian and ultradian variations of leptin in normal man under continuous enteral nutrition: relationship to sleep and body temperature. J Clin Endocrinol Metab 1998; 83: 1893–1899.
  • Støving RK, Vinten J, Handberg A, et al. Diurnal variation of the serum leptin concentration in patients with anorexia nervosa. Clin Endocrinol 1998; 48: 761–768.
  • Havel PJ, Townsend R, Chaump L, et al. High-fat meals reduce 24-h circulating leptin concentrations in women. Diabetes 1999; 48: 334–341.
  • Laughlin GA, Dominguez CE Yen SSC. Nutritional and endocrine-metabolic aberrations in women with functional hypothalamic amenorrhea. J Clin Endocrinol Metab 1998; 83: 25–32.
  • Laughlin GA, Yen SSC. Hypoleptinemia in women athletes: absence of a diurnal rhythm with amenorrhea. J Clin Endocrinol Metab 1997; 82: 318–321.
  • Sakane N, Yoshida T, Mizutani T, et al. Serum leptin levels in a patient with pheochro-mocytoma. J Clin Endocrinol Metab 1998; 83: 1400.
  • Duclos M, Corcuff J-B, Ruffie A, et al. Rapid leptin decrease in immediate post-exercise recovery. Clin Endocrinol 1999; 50: 337–342.
  • Boden G, Chen X, Kolaczynski JW, et al. Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects. J Clin Invest 1997; 100: 1107–1113.
  • Van Cauter E. Diurnal and ultradian rhythms in human endocrine function: a minireview. Horm Res 1990; 34: 45–53.
  • Scheen AJ, Van Cauter E. The roles of time of day and sleep quality in modulating glucose regulation: clinical implications. Horm Res 1998; 49: 191–201.
  • Elimam A, Knutsson U, Brönnegård M, et al. Variations in glucocorticoid levels within the physiological range affect plasma leptin levels. Eur J Endocrinol 1998; 139: 615–620.
  • Cella LK, Van Cauter E Schoeller DA. Diurnal rhythmicity of human cholesterol synthe sis: normal pattern and adaptation to simulated “jet lag”. Am J Physiol 1995; 269: E489–E498.
  • Cella LK, Van Cauter E Schoeller DA. Effect of meal timing on diurnal rhythm of human cholesterol synthesis. Am J Physiol 1995; 269: E878–E883.
  • Murphy PJ, Campbell SS. Nighttime drop in body temperature: a physiological trigger for sleep onset? Sleep 1997; 20: 505–511.
  • Furlan R, Guzzetti S, Crivellaro W, et al. Continuous 24-hour assessment of the neural regulation of systemic arterial pressure and RR variabilities in ambulant subjects. Circulation 1990; 81: 537–547.
  • Degaute J-P, van de Borne P, Linkowski P, et al. Quantitative analysis of the 24-hour blood pressure and heart rate patterns in young men. Hypertension 1991; 18: 199–210.
  • Stene M, Panagiotis N, Tuck ML, et al. Plasma norepinephrine levels are influenced by sodium intake, glucocorticoid administration, and circadian changes in normal man. J Clin Endocrinol Metab 1980; 51: 1340–1345.
  • Linsell CR, Lightman SL, Mullen PE, et al. Circadian rhythms of epinephrine and norepi-nephrine in man. J Clin Endocrinol Metab 1985; 60: 1210–1215.
  • Prinz PN, Halter J, Benedetti C, et al. Circadian variation of plasma catecholamines in young and old men: relation to rapid eye movement and slow wave sleep. J Clin Endocrinol Metab 1979; 49: 300–304.
  • Schöfl C, Becker C, Prank K, et al. Twenty-four-hour rhythms of plasma catecholamines and their relation to cardiovascular parameters in healthy young men. Eur J Endocrinol 1997; 137: 675–683.
  • Böttner A, Eisenhofer G, Torpy DJ, et al. Lack of leptin suppression in response to hypersecretion of catecholamines in pheochromocytoma patients. Metabolism 1999; 48: 543–545.
  • Donahoo WT, Jensen DR, Yost TJ, et al. Isoproterenol and somatostatin decrease plasma leptin in humans: a novel mechanism regulating leptin secretion. J Clin Endocrinol Metab 1997; 82: 4139–4143.
  • Pinkney JH, Coppack SW Mohamed-Ali V. Effect of isoprenaline on plasma leptin and lipolysis in humans. Clin Endocrinol 1998; 48: 407–411.
  • Ricci MR, Fried SK. Isoproterenol decreases leptin expression in adipose tissue of obese humans. Obesity Res 1999; 7: 233–240.
  • Ricci MR, Fried SK Mittleman KD. Acute cold exposure decreases plasma leptin in women. FASEB J 1999; 13: A750.
  • Evans BA, Agar L Summers RJ. The role of the sympathetic nervous system in the regulation of leptin synthesis in C57BL/6 mice. FEBS Lett 1999; 444: 149–154.
  • Gettys TW, Harkness PJ Watson PM. The b3-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes. Endocrinology 1996; 137: 4054–4057.
  • Trayhurn P, Duncan JS Rayner DV. Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: mediation by the sympathetic system. Biochem J 1995; 311: 729–733.
  • Rayner DV, Simón E, Duncan JS, et al. Hyperleptinemia in mice induced by administration of the tyrosine hydroxylase inhibitor a-methyl-p-tyrosine. FEBS Lett 1998; 429: 395–398.
  • Saladin R, De Vos P, Guerre-Millo M, et al. Transient increase in obese gene expression after food intake or insulin administration. Nature 1995; 377: 527–529.
  • Ahima RS, Prabakaran D Flier JS. Postnatal surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function. J Clin Invest 1998; 101: 1020–1027.
  • Simon C. Ultradian pulsatility of plasma glucose and insulin secretion rate: circadian and sleep modulation. Horm Res 1998; 49: 185–190.
  • Sonnenberg GE, Hoffmann RG, Johnson CP, et al. Low- and high-frequency insulin secretion pulses in pancreas transplant recipients: role of extrinsic innervation. J Clin Invest 1992; 90: 545–553.
  • Kern W, Born J, Fehm HL, et al. Sustained oscillatory insulin secretion after pancreas transplantation. Horm Metab Res 1990; 22: 644–646.
  • Collins S, Kuhn CM, Petro AE, et al. Role of leptin in fat regulation. Nature 1996; 380: 677.
  • Commins SP, Watson PM, Padgett MA, et al. Induction of uncoupling protein expression in brown and white adipose tissue by leptin. Endocrinology 1999; 140: 292–300.
  • Cusin I, Zakrewska KE, Boss O, et al. Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins. Diabetes 1998; 47: 1014–1019.
  • Satoh N, Ogawa Y, Katsuura G, et al. Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system. Neurosci Lett 1998; 249: 107–110.
  • Scarpace PJ, Matheny M. Leptin induction of UCP1 gene expression is dependent on sympathetic innervation. Am J Physiol 1998; 275: E259–E264.
  • Kamohara S, Burcelin R, Halaas JL, et al. Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 1997; 389: 374–377.
  • Minokoshi Y, Haque MS Shimazu T. Microinjection of leptin in the ventromedial hypo-thalamus increases glucose uptake in peripheral tissues in rats. Diabetes 1999; 48: 287–291.
  • Sarmiento U, Benson B, Kaufman S, et al. Morphologic and molecular changes induced by recombinant human leptin in the white and brown adipose tissues of C57BL/6 mice. Lab Invest 1997; 77: 243–256.
  • Siegrist-Kaiser CA, Pauli V, Juge-Aubry CE, et al. Direct effects of leptin on brown and white adipose tissues. J Clin Invest 1997; 100: 2858–2864.
  • Haynes WG, Morgan DA, Walsh SA, et al. Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 1997; 107: 270–278.
  • Haynes WG, Sivitz WI, Morgan DA, et al. Sympathetic and cardiorenal actions of leptin. Hypertension 1997; 30: 619–623.
  • Haynes WG. Cardiovascular consequences of obesity: role of leptin. Clin Exp Pharmacol Physiol 1998; 25: 65–69.
  • Haynes WG, Morgan DA, Djalali A, et al. Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension 1999; 33(Part II): 542–547.
  • Tang-Christensen M, Havel PJ, Jacobs RR, et al. Central administration of leptin inhibits food intake and activates the sympathetic nervous system in rhesus macaques. J Clin Endocrinol Metab 1999; 84: 711–717.
  • Bartness TJ, Bamshad M. Innervation of mammalian white adipose tissue: implications for the regulation of total body fat. Am J Physiol 1998; 275: R1399–R1411.
  • Bamshad M, Aoki VT, Adkison MG, et al. Central nervous system origins of the sympathetic nervous system outflow to white adipose tissue. Am J Physiol 1998; 275: R291–R299.
  • Giordano A, Morroni M, Carle F, et al. Sensory nerves affect the recruitment and differentiation of rat periovarian brown adipocytes during cold acclimation. J Cell Sci 1998; 111: 2587–2594.
  • Cousin B, Casteilla L, Lafontan M, et al. Local sympathetic denervation of white adipose tissue in rats induces preadipocyte proliferation without noticeable changes in metabolism. Endocrinology 1993; 133: 2255–2262.
  • Youngstrom TG, Bartness TJ. White adipose tissue sympathetic nervous system denerva-tion increases fat pad mass and fat cell number. Am J Physiol 1998; 275: R1488–R1493.
  • Migliorini RH, Garofalo MAR Kettelhut IC. Increased sympathetic activity in rat white adipose tissue during prolonged fasting. Am J Physiol 1997; 272: R656–R661.
  • Garofalo MAR, Kettelhut IC, Roselino JES, et al. Effect of acute cold exposure on norepinephrine turnover rates in rat white adipose tissue. J Autonom Nerv Syst 1996; 60: 206–208.
  • Weigle DS, Duell PB, Connor WE, et al. Effect of fasting, refeeding, and dietary fat restriction on plasma leptin levels. J Clin Endocrinol Metab 1997; 82: 561–565.
  • Boden G, Chen X, Mozzoli M, et al. Effect of fasting on serum leptin in normal human subjects. J Clin Endocrinol Metab 1996; 81: 3419–3423.
  • Kolaczynski JW, Considine RV, Ohannesian J, et al. Responses of leptin to short-term fasting and refeeding in humans. Diabetes 1996; 45: 1511–1515.
  • Grinspoon SK, Askari H, Landt ML, et al. Effects of fasting and glucose infusion on basal and overnight leptin concentrations in normal-weight women. Am J Clin Nutr 1997; 66: 1352–1356.
  • Christensen NJ, Galbo H. Sympathetic nervous system activity during exercise. Annu Rev Physiol 1983; 45: 139–153.
  • Banks WA, Kastin AJ, Huang W, et al. Leptin enters the brain by a saturable system independent of insulin. Peptides 1996; 17: 305–311.
  • Caro JF, Kolaczynski JW, Nyce MR, et al. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996; 348: 159–161.
  • Dötsch J, Adelmann M, Englaro P, et al. Relation of leptin and neuropeptide Y in human blood and cerebrospinal fluid. J Neurol Sci 1997; 151: 185–188.
  • Koistinen HA, Karonen S-L, Iivanainen M, et al. Circulating leptin has saturable transport into intrathecal space in humans. Eur J Clin Invest 1998; 28: 894–897.
  • Mantzoros CS, Flier JS, Lesem MD, et al. Cerebrospinal fluid leptin in anorexia nervosa correlation with nutritional status and potential role in resistance to weight gain. J Clin Endocrinol Metab 1997; 82: 1845–1851.
  • Schwartz MW, Peskind E, Raskind M, et al. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med 1996; 2: 589–593.
  • Bjørbæk C, Elmquist JK, Michl P, et al. Expression of leptin receptor isoforms in rat brain microvessels. Endocrinology 1998; 139: 3485–3491.
  • Wang YH, Taché Y, Sheibel AB, et al. Two types of leptin-responsive gastric vagal afferent terminals: an in vitro single-unit study in rats. Am J Physiol 1997; 273: R833–R837.
  • Niijima A. Afferent signals from leptin sensors in the white adipose tissue of the epididy-mis, and their reflex effect in the rat. J Autonom Nerv Sys 1998; 73: 19–25.
  • Niijima A. Reflex effects from leptin sensors in the white adipose tissue of the epididymis to the efferent activity of the sympathetic and vagus nerve in the rat. Neurosci Lett 1999; 262: 125–128.
  • Tataranni PA. From physiology to neuroendocrinology: a reappraisal of risk factors of body weight gain in humans. Diabetes Metab 1998; 23: 108–115.
  • Coleman DL. Obesity genes: beneficial effects in heterozygous mice. Science 1979; 203: 663–665.
  • Zhang Y, Olbort M, Schwarzer K, et al. The leptin receptor mediates apparent autocrine regulation of leptin gene expression. Biochem Biophys Res Commun 1997; 240: 492–495.
  • Elmquist JK, Maratos-Flier E, Saper CB, et al. Unraveling the central nervous system pathways underlying responses to leptin. Nat Neurosci 1998; 1: 445–450.
  • Bray GA, York DA. The MONA LISA hypothesis in the time of leptin. Rec Progr Horm Res 1998; 53: 95–118.
  • Flier JS, Maratos-Flier E. Obesity and the hypothalamus: novel peptides for new pathways. Cell 1998; 92: 437–440.
  • Poitout V, Rouault C, Guerre-Millo M, et al. Does leptin regulate insulin secretion? Diabetes Metab 1998; 24: 313–318.
  • Kieffer TJ, Heller RS, Leech CA, et al. Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic b-cells. Diabetes 1997; 46: 1087–1093.
  • Mizuno A, Murakami T, Otani S, et al. Leptin affects pancreatic endocrine functions through the sympathetic nervous system. Endocrinology 1998; 139: 3863–3870.
  • Kieffer TJ, Heller RS Habener JF. Leptin receptors expressed on pancreatic b-cells. Biochem Biophys Res Commun 1996; 224: 522–527.
  • Seufert J, Kieffer TJ, Leech CA, et al. Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. J Clin Endocrinol Metab 1999; 84: 670–676.
  • Lupi R, Marchetti P, Maffei M, et al. Effects of acute or prolonged exposure to human leptin on isolated human islet function. Biochem Biophys Res Commun 1999; 256: 637–641.
  • Fehmann HC, Berghöfer P, Brandhorst D, et al. Leptin inhibition of insulin secretion from isolated human islets. Acta Diabetol 1997; 34: 249–252.
  • Cohen B, Novick D Rubinstein M. Modulation of insulin activities by leptin. Science 1996; 274: 1185–1188
  • Wang Y, Kuropatwinski KK, White DW, et al. Leptin receptor action in hepatic cells. J Biol Chem 1997; 272: 16216–16223.
  • Nemecz M, Preininger K, Englisch R, et al. Acute effect of leptin on hepatic glycogenolysis and gluconeogenesis in perfused rat liver. Hepatology 1999; 29: 166–172.
  • Widdowson PS, Upton R, Pickavance L, et al. Acute hyperleptinemia does not modify insulin sensitivity in vivo in the rat. Horm Metab Res 1998; 30: 259–262.
  • Rossetti L, Massillon D, Barzilai N, et al. Short term effects of leptin on hepatic gluconeo-genesis and in vivo insulin action. J Biol Chem 1997; 272: 27758–27763.
  • Sivitz WI, Walsh SA, Morgan DA, et al. Effects of leptin on insulin sensitivity in normal rats. Endocrinology 1997; 138: 3395–3401.
  • Pralong FP, Roduit R, Waeber G, et al. Leptin inhibits directly glucocorticoid secretion of normal human and rat adrenal gland. Endocrinology 1998; 139: 4264–4268.
  • Harris RBS, Zhou J, Redmann Jr SM, et al. A leptin dose-response study in obese (ob/ob) and lean (+/?) mice. Endocrinology 1998; 139: 8–19.
  • Flynn MC, Scott TR, Pritchard TC, et al. Mode of action of OB protein (leptin) on feeding. Am J Physiol 1998; 275: R174–R179.
  • Larsson H, Elmståhl S, Berglund G, et al. Evidence for leptin regulation of food intake in humans. J Clin Endocrinol Metab 1998; 83: 4382–4385.
  • Melnyk A, Harper M-E Himms-Hagen J. Raising at thermoneutrality prevents obesity and hyperphagia in BAT-ablated transgenic mice. Am J Physiol 1997; 272: R1088–R1093.
  • Melnyk A, Himms-Hagen J. Temperature-dependent feeding: lack of role for leptin and defect in brown adipose tissue-ablated obese mice. Am J Physiol 1998; 274: R1131–R1135.
  • Coleman DL. Thermogenesis in diabetes-obesity syndromes in mutant mice. Diabetologia 1982; 22: 205–211.
  • Strohmayer AJ, Smith GP. The meal pattern of genetically obese (ob/ob) mice. Appetite 1987; 8: 111–123.
  • Freedman MR, Castonguay TW Stern JS. Effect of adrenalectomy and corticosterone replacement on meal patterns of Zucker rats. Am J Physiol 1985; 249: R584–R594.
  • Alingh Prins A, de Jong-Nagelsmit A, Keijser J, et al. Daily rhythms of feeding in the genetically obese and lean Zucker rats. Physiol Behav 1986; 38: 423–426.
  • Kahler A, Geary N, Eckel LA, et al. Chronic administration of OB protein decreases food intake by selectively reducing meal size in male rats. Am J Physiol 1998; 275: R180–R185.
  • Eckel LA, Langhans W, Kahler A, et al. Chronic administration of OB protein decreases food intake by selectively reducing meal size in female rats. Am J Physiol 1998; 275: R186–R193.
  • Hulsey MG, Lu H, Wang T, et al. Intracerebroventricular (i.c.v.) administration of mouse leptin in rats: behavioral specificity and effects on meal patterns. Physiol Behav 1998; 65: 445–455.
  • Himms-Hagen J. Role of brown adipose tissue thermogenesis in control of thermoregula-tory feeding in rats: a new hypothesis that links thermostatic and glucostatic hypotheses for control of food intake. Proc Soc Exp Biol Med 1995; 208: 159–169.
  • Brunner L, Nick HP, Cumin F, et al. Leptin is a physiologically important regulator of food intake. Int J Obesity 1997; 21: 1152–1160.
  • Swick AG, Kemnitz JW, Houser WD, et al. Norepinephrine stimulates activity of brown adipose tissue in rhesus monkeys. Int J Obesity 1986; 10: 241–244.
  • Fisher MH, Amend AM, Bach TJ, et al. A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys. J Clin Invest 1998; 101: 2387–2393.
  • Kolaczynski JW, Ohannesian J, Considine RV, et al. Response of leptin to short-term and prolonged overfeeding in humans. J Clin Endocrinol Metab 1996; 81: 4162–4165.
  • Havel PJ, Kasim-Karakas S, Mueller W, et al. Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss. J Clin Endocrinol Metab 1996; 81: 4406–4413.
  • Miller KK, Parulekar MS, Schoenfeld E, et al. Decreased leptin levels in normal weight women with hypothalamic amenorrhea: the effects of body composition and nutritional intake. J Endocrinol Metab 1998; 83: 2309–2312.
  • Couzinet B, Young J, Brailly S, et al. Functional hypothalamic amenorrhoea: a partial and reversible gonadotropin deficiency of nutritional origin. Clin Endocrinol 1999; 50: 229–235.
  • Cha MC, Jones PJH. Dietary fat type and energy restriction interactively influence plasma leptin concentration in rats. J Lipid Res 1998; 39: 1655–1660.
  • Smith FJ, Rivera I, Tenenbaum R, et al. Weight loss reverses decreased sensitivity to exogenous OB protein (leptin) in diet-induced obese mice. Obesity Res 1998; 22(Suppl 3)</b>: S41.
  • Lu H, Duanmu Z, Houck C, et al. Obesity due to high fat diet decreases the sympathetic nervous and cardiovascular responses to intracerebroventricular leptin in rats. Brain Res Bull 1998; 47: 331–335.
  • Judd SJ. Disturbances of the reproductive axis induced by negative energy balance. Reprod Fertil Dev 1998; 10: 65–72.
  • Cunningham MJ, Clifton DK Steiner RA. Leptin’s action on the reproductive axis: perspectives and mechanisms. Biol Reprod 1999; 60: 216–222.
  • Clarke IJ, Henry BA. Leptin and reproduction. Rev Reprod 1999; 4: 48–55.
  • Karlsson C, Lindell K, Svensson E, et al. Expression of functional leptin receptors in the human ovary. J Clin Endocrinol Metab 1997; 82: 4144–4148.
  • Agarwal SK, Vogel K, Weitsman SR, et al. Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulosa and theca cells of the human ovary. J Clin Endocrinol Metab 1999; 84: 1072–1076.
  • Barkan D, Jia H, Dantes A, et al. Leptin modulates the glucocorticoid-induced ovarian steroidogenesis. Endocrinology 1999; 140: 1731–1738.
  • Antczak M, Van Blerkom J. Oocyte influences on early development: the regulatory proteins leptin and STAT3 are polarized in mouse and human oocytes and differentially distributed within the cells of the preimplantation stage embryo. Mol Hum Reprod 1997; 3: 1067–1086.
  • Strowitzki T, Kellerer M, Capp E, et al. Increase in serum leptin concentrations in women undergoing controlled ovarian hyperstimulation for assisted reproduction. Gynecol Endocrinol 1998; 12: 167–169.
  • Bi S, Gavrilova O, Gong D-W, et al. Identification of a placental enhancer for the human leptin gene. J Biol Chem 1997; 272: 30583–30588.
  • Ebihara K, Ogawa Y, Isse N, et al. Identification of the human leptin 5¢ flanking sequences involved in the trophoblast-specific transcription. Biochem Biophys Res Commun 1997; 241: 658–663.
  • Hoggard N, Hunter L, Duncan JS, et al. Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta. Proc Natl Acad Sci USA 1997; 94: 11073–11078.
  • Kawai M, Yamaguchi M, Murakami T, et al. The placenta is not the main source of leptin production in the pregnant rat: gestational profile of leptin in plasma and adipose tissues. Biochem Biophys Res Commun 1997; 240: 798–802.
  • Ertl T, Funke S, Sárkány I, et al. Postnatal changes of leptin levels in full-term and preterm neonates: their relation to intrauterine growth, gender and testosterone. Biol Neonate 1999; 75: 167–176.
  • Varvarigou A, Mantzoros CS Beratis NG. Cord blood leptin concentrations in relation to intrauterine growth. Clin Endocrinol 1999; 50: 177–183.
  • Ong KKL, Ahmed ML, Sherriff A, et al. Cord blood leptin is associated with size at birth and predicts infancy weight gain in humans. J Clin Endocrinol Metab 1999; 84: 1145–1148.
  • Tarquini B, Tarquini R, Perfetto F, et al. Genetic and environmental influences on human cord blood leptin concentration. Pediatrics 1999; 103: 998–1006.
  • Harigaya A, Nagashima K, Nako Y, et al. Relationship between concentration of serum leptin and fetal growth. J Clin Endocrinol Metab 1997; 82: 3281–3284.
  • Marchini G, Fried G, Östlund E, et al. Plasma leptin in infants: relations to birth weight and weight loss. Pediatrics 1998; 101: 429–432.
  • Schübring C, Siebler T, Englaro P, et al. Rapid decline of serum leptin levels in healthy neonates after birth. Eur J Pediatr 1998; 157: 263–264.
  • Schübring C, Englaro P, Siebler T, et al. Longitudinal analysis of maternal serum leptin during pregnancy, at birth and up to six weeks after birth: relation to body mass index, skinfolds, sex steroids and umbilical cord blood leptin levels. Horm Res 1998; 50: 276–283.
  • Matsuda J, Yokota I, Iida M, et al. Dynamic changes in serum leptin concentrations during the fetal and neonatal periods. Pediatr Res 1999; 45: 71–75.
  • Himms-Hagen J. Does thermoregulatory feeding occur in newborn infants? A novel view of the role of brown adipose tissue thermogenesis in control of food intake. Obesity Res 1995; 3: 361–369.
  • Jaquet D, Leger J, Levy-Marchal C, et al. Ontogeny of leptin in human fetuses and newborns: effect of intrauterine growth retardation on serum leptin concentrations. J Clin Endocrinol Metab 1998; 83: 1243–1246.
  • Mantzoros CS, Varvarigou A, Kaklamani VG, et al. Effect of birth weight and maternal smoking on cord blood leptin concentrations of full-term and preterm newborns. J Clin Endocrinol Metab 1997; 82: 2856–2861.
  • Gomez L, Carrascosa A, Yeste D, et al. Leptin values in placental cord blood of human newborns with normal intrauterine growth after 30-42 weeks of gestation. Horm Res 1999; 51: 10–14.
  • Matsuda J, Yokota I, Iida M, et al. Serum leptin concentration in cord blood: relationship to birth weight and gender. J Clin Endocrinol Metab 1997; 82: 1642–1644.
  • Clapp III JF, Kiess W. Cord blood leptin reflects fetal fat mass. J Soc Gynecol Invest 1998; 5: 300–303.
  • Shekhawat PS, Garland JS, Shivpuri C, et al. Neonatal cord blood leptin: its relationship to birth weight, body mass index, maternal diabetes, and steroids. Pediatr Res 1998; 43: 338–343.
  • Rayner DV, Dalgliesh GD, Duncan JS, et al. Postnatal development of the ob gene system: elevated leptin levels in suckling fa/fa rats. Am J Physiol 1997; 273: E446–R450.
  • Devaskar SU, Ollesch C, Rajakumar RA, et al. Developmental changes in ob gene expression and circulating leptin peptide concentrations. Biochem Biophys Res Commun 1997; 238: 44–47.
  • Dessolin S, Schalling M, Champigny O, et al. Leptin gene is expressed in rat brown adipose tissue at birth. FASEB J 1997; 11: 382–387.
  • Dubuc PU. Transient postweaning expression of excessive fat deposition and diabetes mellitus in ob/ob mice. Growth Dev Aging 1996; 60: 145–151.
  • Kowalski TJ, Ster AM Smith GP. Ontogeny of hyperphagia in the Zucker (fa/fa) rat. Am J Physiol 1998; 275: R1106–R1109.
  • Butte NF, Hopkinson JM Nicolson MA. Leptin in human reproduction: serum leptin levels in pregnant and lactating women. J Clin Endocrinol Metab 1997; 82: 585–589.
  • Highman TJ, Friedman JE, Huston LP, et al. Longitudinal changes in maternal serum leptin concentrations, body composition, and resting metabolic rate in pregnancy. Am J Obstet Gynecol 1998; 178: 1010–1015.
  • Sattar N, Greer IA, Pirwani I, et al. Leptin levels in pregnancy: marker for fat accumulation and mobilization? Acta Obstet Gynecol Scand 1998; 77: 278–283.
  • Lewandowski K, Horn R, O’Callaghan CJ, et al. Free leptin, bound leptin, and soluble leptin receptor in normal and diabetic pregnancies. J Clin Endocrinol Metab 1999; 84: 300–306.
  • Tomé MA, Lage M, Camiña J P, et al. Sex-based differences in serum leptin concentrations from umbilical cord blood at delivery. Eur J Endocrinol 1997; 137: 655–658.
  • Terada Y, Yamakawa K, Sugaya A, et al. Serum leptin levels do not rise during pregnancy in age-matched rats. Biochem Biophys Res Commun 1998; 253: 841–844.
  • Chehab FF. The reproductive side of leptin. Nat Med 1997; 3: 952–953.
  • Hoggard N, Hunter L, Trayhurn P, et al. Leptin and reproduction. Proc Nutr Soc 1998; 57: 421–427.
  • Edmonds DK. Leptin and the onset of puberty. Curr Opin Obstet Gynecol 1998; 10: 361–363.
  • Kiess W, Blum WF Aubert ML. Leptin, puberty and reproductive function: lessons from animal studies and human observations. Eur J Endocrinol 1998; 138: 26–29.
  • Berger A, Brand M O’Rahilly S. Uncoupling proteins: the unraveling of obesity? Br Med J 1998; 317: 1607–1608.
  • Ahmed ML, Ong KKL, Morell DJ, et al. Longitudinal study of leptin concentrations during puberty: sex differences and relationship to changes in body composition. J Clin Endocrinol Metab 1999; 84: 899–905.
  • Rogol AD. Editorial: leptin and puberty. J Clin Endocrinol Metab 1998; 83: 1089–1090.
  • Mantzoros CS, Flier JS Rogol AD. A longitudinal assessment of hormone and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. J Endocrinol Metab 1997; 82: 1066–1070.
  • Silverman KJ, Lund DP, Zetter BR, et al. Angiogenic activity of adipose tissue. Biochem Biophys Res Commun 1988; 153: 347–352.
  • Zhang QX, Magovern CJ, Mack CA, et al. Vascular endothelial growth factor is the major angiogenic factor in omentum: mechanism of the omentum-mediated angiogenesis. J Surg Res 1997; 67: 147–154.
  • Sierra-Honigmann M, Nath AK, Murakami C, et al. Biological action of leptin as an angiogenic factor. Science 1998; 281: 1683–1686.
  • Bouloumié A, Drexler HCA, Lafontan M, et al. Leptin, the product of Ob gene, promotes angiogenesis. Circ Res 1998; 83: 1059–1066.
  • Crandall DL, Hausman GJ Kral JG. A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives. Microcirculation 1997; 4: 211–232.
  • Chandra RK. Cell-mediated immunity in genetically obese (C57BL/6J ob/ob) mice. Am J Clin Nutr 1980; 33: 13–16.
  • Fernandes G, Handwerger BS, Yunis EJ, et al. Immune response in the mutant diabetic C57BL/Ks-db+ mouse. J Clin Invest 1978; 61: 243–250.
  • Stallone DD. The influence of obesity and its treatment on the immune system. Nutr Rev 1994; 52: 37–50.
  • Lee F-YJ, Li Y, Yang EK, et al. Phenotypic abnormalities in macrophages from leptin-deficient, obese mice. Am J Physiol 1999; 276: C386–C394.
  • Lord GM, Matarese G, Howard JK, et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998; 394: 897–901.
  • Bennett BD, Solar GP, Yuan JQ, et al. A role for leptin and its cognate receptor in hematopoiesis. Curr Biol 1996; 6: 1170–1180.
  • Flier JS. Lowered leptin slims immune response. Nat Med 1998; 4: 1124–1125.
  • Besedovsky HO, del Rey A. Immune-neuro-endocrine interactions: facts and hypotheses. Endocr Rev 1996; 17: 64–102.
  • Cioffi JA, Shafer AW, Zupanic TJ, et al. Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nat Med 1996; 3: 585–589.
  • Lacaud G, Carlsson L Keller G. Identification of a fetal hematopoietic precursor with B cell, T cell and macrophage potential. Immunity 1998; 9: 827–838.
  • Snodgrass HR. Retraction. Blood 1997; 90: 2862.
  • Mikhail AA, Beck EX, Shafer A, et al. Leptin stimulates fetal and adult erythroid and myeloid development. Blood 1997; 89: 1507-1512. (Retraction in Blood 90: 2862).
  • Umemoto Y, Tsuji K, Yang F-C, et al. Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic progenitor cells. Blood 1997; 90: 3438–3443.
  • Santos-Alvarez J, Goberna R Sánchez-Margalet V. Human leptin stimulates proliferation and activation of human circulating monocytes. Cell Immunol 1999; 194: 6–11.
  • Gainsford T, Willson TA, Metcalf D, et al. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci USA 1996; 93: 14564–14568.
  • Loffreda S, Yang SQ, Lin HZ, et al. Leptin regulates proinflammatory immune responses. FASEB J 1998; 12: 57–65.
  • Thomas T, Gori F, Khosla S, et al. Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology 1999; 140: 1630–1638.
  • Choban PS, Heckler R, Burge JC, et al. Increased incidence of nosocomial infections in obese surgical patients. Am Surg 1995; 61: 1001–1005.
  • Everson CA. Functional consequences of sustained sleep deprivation in the rat. Behav Brain Res 1995; 69: 43–54.
  • Everson CA, Reed HL. Pituitary and peripheral thyroid hormone responses to thyrotropin-releasing hormone during sustained sleep deprivation in freely moving rats. Endocrinology 1995; 136: 1426–1434.
  • Rechtschaffen A, Bergmann P. Sleep deprivation in the rat by the disk-over-water method. Behav Brain Res 1995; 69: 55–63.
  • Shaw PJ, Bergmann BM Rechtschaffen A. Operant control of ambient temperature during sleep deprivation. Am J Physiol 1997; 272: R682–R690.
  • Shaw PJ, Bergmann BM Rechtschaffen A. Effects of paradoxical sleep deprivation on thermoregulation in the rat. Sleep 1998; 21: 7–17.
  • Shephard RJ, Shek PN. Interactions between sleep, other body rhythms, immune responses, and exercise. Can J Appl Physiol 1997; 22: 95–116.
  • Benca RM, Quintans J. Sleep and host defenses: a review. Sleep 1997; 20: 1027–1037.
  • Dinges DF, Douglas SD, Zaugg L, et al. Leukocytosis and natural killer cell function parallel neurobehavioral fatigue induced by 64 h of sleep deprivation. J Clin Invest 1994; 93: 1930–1939.
  • Irwin M, Mascovich A, Gillin JC, et al. Partial sleep deprivation reduces natural killer cell activity in humans. Psychosom Med 1994; 56: 493–498.
  • Estey F, Thall P, Kantarjian H, et al. Association between increased body mass index and a diagnosis of acute promyelocytic leukemia in patients with acute myeloid leukemia. Leukemia 1997; 11: 1661–1664.
  • Konopleva M, Mikhail A, Estrov Z, et al. Expression and function of leptin receptors isoforms in myeloid leukemia and myelodysplastic syndromes: proliferative and anti-apoptotic activities. Blood 1999; 93: 1668–1676.
  • Masuzaki H, Ogawa Y, Hosoda K, et al. Glucorticoid regulation of leptin synthesis and secretion in humans: elevated plasma leptin levels in Cushing’s syndrome. J Clin Endocrinol Metab 1997; 82: 2542–2547.
  • Russell CD, Petersen RN, Rao SP, et al. Leptin expression in adipose tissue from obese humans: depot-specific regulation by insulin and dexamethasone. Am J Physiol 1998; 275: E507–E515.
  • Dagogo-Jack S, Selke G, Melson AK, et al. Robust leptin secretory responses to dexam-ethasone in obese subjects. J Endocrinol Metab 1997; 82: 3230–3233.
  • Newcomer JW, Selke G, Melson AK, et al. Dose-dependent cortisol-induced increases in plasma leptin concentration in healthy humans. Arch Gen Psychiatry 1998; 55: 995–1000.
  • Larsson H, Ahrén B. Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women. J Endocrinol Metab 1996; 81: 4428–4432.
  • Kolaczynski JW, Goldstein BJ Considine RV. Dexamethasone, OB gene, and leptin in humans: effect of exogenous hyperinsulinemia. J Clin Endocrinol Metab 1997; 82: 3895–3897.
  • Miell JP, Englaro P Blum WF. Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects. Horm Metab Res 1996; 28: 704–707.
  • Halleux CM, Servais I, Reul BA, et al. Multihormonal control of ob gene expression and leptin secretion from cultured human visceral adipose tissue: increased responsiveness to glucocorticoids in obesity. J Clin Endocrinol Metab 1998; 83: 902–910.
  • Cizza G, Lotsikas AJ, Licinio J, et al. Plasma leptin levels do not change in patients with Cushing’s disease shortly after correction of hypercortisolism. J Clin Endocrinol Metab 1997; 82: 2747–2750.
  • Iida M, Murakami T, Yamada M, et al. Hyperleptinemia in chronic renal failure. Horm Metab Res 1996; 28: 724–727.
  • Nishizawa Y, Shoji T, Tanaka S, et al. Plasma leptin level and its relationship with body composition in hemodialysis patients. Am J Kidney Dis 1998; 31: 655–661.
  • Merabet E, Dagogo-Jack S, Coyne DW, et al. Increased plasma leptin concentration in end-stage renal disease. J Clin Endocrinol Metab 1997; 82: 847–850.
  • Sharma K, Considine RV, Michael B, et al. Plasma leptin is cleared by the kidney and is elevated in hemodialysis patients. Kidney Int 1997; 51: 1980–1985.
  • Sharma K, Considine RV. The OB protein (leptin) and the kidney. Kidney Int 1998; 53: 1483–1487.
  • Shoji T, Nishizawa Y, Emoto M, et al. Renal function and insulin resistance as determinants of plasma leptin levels in patients with NIDDM. Diabetologia 1997; 40: 676–679.
  • Johansen KL, Mulligan K, Tal V, et al. Leptin, body composition, and indices of malnutrition in patients on dialysis. J Am Soc Nephrol 1998; 9: 1080–1084.
  • Dagogo-Jack S, Ovalle F, Landt M, et al. Hyperleptinemia in patients with end-stage renal disease undergoing continuous ambulatory peritoneal dialysis. Perit Dial Int 1998; 18: 34–40.
  • Daschner M, Tönshoff B, Blum WF, et al. Inappropriate elevation of the serum leptin levels in children with chronic renal failure. J Am Soc Nephrol 1998; 9: 1074–1079.
  • Kokot F, Adamczak M Wiecek A. Plasma leptin concentration in kidney transplant patients during the early post-transplant period. Nephrol Dial Transplant 1998; 13: 2276–2280.
  • Kokot F, Wiecek A, Adamczak M, et al. Pathophysiological role of leptin in patients with chronic renal failure, in kidney transplant patients, in patients with essential hypertension, and in pregnant women with preeclampsia. Artif Organs 1999; 23: 70–74.
  • Kokot F, Adamczak M, Wiecek A, et al. Plasma immunoreactive leptin and neuropeptide Y levels in kidney transplant patients. Am J Nephrol 1999; 19: 28–33.
  • Stenvinkel P. Leptin — a new hormone of definite interest for the nephrologist. Nephrol Dial Transplant 1998; 13: 1099–1101.
  • Wiesholzer M, Harm F, Hauser A-C, et al. Inappropriately high plasma leptin levels in obese haemodialysis patients can be reduced by high flux haemodialysis and haemodiafiltration. Clin Sci 1998; 94: 431–435.
  • Coyne DW, Dagogo-Jack S, Klein S, et al. High-flux dialysis lowers plasma leptin concentration in chronic dialysis patients. Am J Kidney Dis 1998; 32: 1031–1035.
  • Landt M, Brennan DC, Parvin CA, et al. Hyperleptinemia of end-stage renal disease is corrected by renal transplantation. Nephrol Dial Transplant 1998; 13: 2271–2275.
  • Landt M, Parvin CA, Dagogo-Jack S, et al. Leptin elimination in hyperleptinaemic peritoneal dialysis patients. Nephrol Dial Transplant 1999; 14: 732–737.
  • Kim DJ, Oh DJ, Kim B, et al. The effect of continuous ambulatory peritoneal dialysis on change in serum leptin. Perit Dial Int 1999; 19(Suppl 2)</b>: S172–S175.
  • Nakazono H, Nagake Y, Ichikawa H, et al. Serum leptin concentrations in patients on hemodialysis. Nephron 1998; 80: 35–40.
  • Mark AL, Correia M, Morgan DA, et al. Obesity-induced hypertension. New concepts from the emerging biology of obesity. Hypertension 1999; 33(Part II): 537–541.
  • Dunbar JC, Hu Y Lu H. Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats. Diabetes 1997; 46: 2040–2043.
  • Casto RM, VanNess JM Overton JM. Effects of central leptin administration on blood pressure in normotensive rats. Neurosci Lett 1998; 246: 29–32.
  • Shek EW, Brands MW Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension 1998; 31: 409–414.
  • Serradeil-Le Gal C, Raufaste D, Brossard G, et al. Characterization and localization of leptin receptors in the rat kidney. FEBS Lett 1997; 404: 185–191.
  • Jackson EK, Li P. Human leptin has natriuretic activity in the rat. Am J Physiol 1997; 272: F333–F338.
  • Villarreal D, Reams G, Freeman RH, et al. Renal effects of leptin in normotensive, hypertensive, and obese rats. Am J Physiol 1998; 275: R2056–R2060.
  • Hirose H, Saito I, Tsujioka M, et al. The obese gene product, leptin: possible role in obesity-related hypertension in adolescents. J Hypertens 1998; 16: 2007–2012.
  • Hirose H, Saito I, Kawai T, et al. Serum leptin level — possible association with haematopoiesis in adolescents independent of body mass index and serum insulin. Clin Sci 1998; 94: 633–636.
  • Schorr U, Blaschke K, Turan S, et al. Relationships between angiotensinogen, leptin and blood pressure levels in young normotensive men. J Hypertens 1998; 16: 1475–1480.
  • Kim-Motoyama H, Yamaguchi T, Katakura T, et al. Serum leptin levels are associated with hyperinsulinemia independent of body mass index but not with visceral obesity. Biochem Biophys Res Commun 1997; 239: 340–344.
  • Leyva F, Godsland IF, Ghatei M, et al. Hyperleptinemia as a component of a metabolic syndrome of cardiovascular risk. Arterioscler Thromb Vasc Biol 1998; 18: 928–933.
  • De Courten M, Zimmet P, Hodge A, et al. Hyperleptinaemia: the missing link in the metabolic syndrome? Diabetic Med 1997; 14: 200–208.
  • Suter PM, Locher R, Häsler E, et al. Is there a role for the ob gene product leptin in essential hypertension? Am J Hypertens 1998; 11: 1305–1311.
  • Söderberg S, Ahrén B, Stegmayr B, et al. Leptin is a risk marker for first-ever hemorrhagic stroke in a population-based cohort. Stroke 1999; 30: 328–337.
  • Mohamed-Ali V, Pinkney JH, Panahloo A, et al. Relationships between plasma leptin and insulin concentrations, but not insulin resistance, in non-insulin-dependent (type 2) diabetes mellitus. Diabetic Med 1997; 14: 76–380.
  • Agata J, Masuda A, Takada M, et al. High plasma immunoreactive leptin level in essential hypertension. Am J Hypertens 1997; 10: 1171–1174.
  • Narkiewicz K, Somers VK, Mos L, et al. An independent relationship between plasma leptin and heart rate in untreated patients with essential hypertension. J Hypertens 1999; 17: 245–249.
  • Aronne LJ, Mackintosh R, Rosenbaum M, et al. Cardiac autonomic nervous system activity in obese and never-obese young men. Obesity Res 1997; 5: 354–359.
  • Snitker S, Pratley RE, Nicolson M, et al. Relationship between muscle sympathetic nerve activity and plasma leptin concentration. Obesity Res 1997; 5: 338–340.
  • Vaz M, Jennings G, Turner A, et al. Regional sympathetic nervous activity and oxygen consumption of obese normotensive human subjects. Circulation 1997; 96: 3423–3429.
  • Grassi G, Colombo M, Seravalle G, et al. Dissociation between muscle and skin sympathetic nerve activity in essential hypertension, obesity, and congestive heart failure. Hypertension 1998; 31: 64–67.
  • Mise H, Sagawa N, Matsumoto T, et al. Augmented placental production of leptin in preeclampsia: possible involvement of placental hypoxia. J Clin Endocrinol Metab 1998; 83: 3225–3229.
  • McCarthy JF, Misra DN Roberts JM. Maternal plasma leptin is increased in preeclampsia and positively correlates with fetal cord concentration. Am J Obstet Gynecol 1999; 180: 731–736.
  • Schobel HP, Fischer T, Heuszer K, et al. Preeclampsia — a state of sympathetic overactivity. N Engl J Med 1996; 335: 1480–1485.
  • Sarraf P, Frederich RC, Turner EM, et al. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med 1997; 185: 171–175.
  • Berkowitz DE, Brown D, Lee YM, et al. Endotoxin-induced alteration in the expression of leptin and b3-adrenergic receptor in adipose tissue. Am J Physiol 1998; 274: E992–E997.
  • Faggioni R, Fuller J, Moser A, et al. LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice. Am J Physiol 1997; 273: R181–R186.
  • Roberts HC, Hardie LJ, Chappell LH, et al. Parasite-induced anorexia: leptin, insulin and corticosterone responses to infection with the nematode, Nippostrongylus brasiliensis. Parasitology 1999; 118: 117–123.
  • Barbier M, Cherbut C, Aubé AC, et al. Elevated plasma leptin concentrations in early stages of experimental intestinal inflammation in rats. Gut 1998; 43: 783–790.
  • Grunfeld C, Zhao C, Fuller J, et al. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. A role for leptin in the anorexia of infection. J Clin Invest 1996; 97: 2152–2157.
  • Moshyedi AK, Josephs MD, Abdalla EK, et al. Increased leptin expression in mice with bacterial peritonitis is partially regulated by tumor necrosis factor alpha. Infect Immun 1998; 66: 1800–1802.
  • Finck BN, Johnson RW. Intracerebroventricular injection of lipopolysaccharide increases plasma leptin levels. Neuroreport 1999; 10: 153–156.
  • Bornstein SR, Licinio J, Tauchnitz R, et al. Plasma leptin levels are increased in survivors of acute sepsis: associated loss of diurnal rhythm in cortisol and leptin secretion. J Clin Endocrinol Metab 1998; 83: 280–283.
  • Torpy DJ, Bornstein SR Chrousos GP. Leptin and interleukin-6 in sepsis. Horm Metab Res 1996; 30: 726–729.
  • Bornstein SR, Preas HL, Chrousos GP, et al. Circulating leptin levels during acute experimental endotoxemia and antiinflammatory therapy in humans. J Infect Dis 1998; 178: 887–890.
  • Carlson GL, Saeed M, Little RA, et al. Serum leptin concentrations and their relation to metabolic abnormalities in human sepsis. Am J Physiol 1999; 276: E658–E662.
  • Roberts GA, Holt RIG, Ghatel MA, et al. Serum leptin and insulin in paediatric end-stage liver disease and following successful orthotopic liver transplantation. Clin Endocrinol 1998; 48: 401–406.
  • Shimizu H, Kakizaki S, Tsuchiya T, et al. An increase of circulating leptin in patients with liver cirrhosis. Int J Obesity 1998; 22: 1234–1238.
  • Brennan BMD, Rahim A, Blum WF, et al. Hyperleptinaemia in young adults following cranial irradiation in childhood: growth hormone deficiency or leptin insensitivity? Clin Endocrinol 1999; 50: 163–169.
  • Coutant R, Lahlou N, Bouvattier C, et al. Circulating leptin level and growth hormone response to stimulation tests in obese and normal children. Eur J Endocrinol 1998; 139: 591–597.
  • Fisker S, Vahl N, Hansen TB, et al. Serum leptin is increased in growth hormone-deficient adults: relationship to body composition and effects of placebo-controlled growth hormone therapy for 1 year. Metabolism 1997; 46: 812–817.
  • Kristensen K, Pedersen SB, Fisker S, et al. Serum leptin levels and leptin expression in growth hormone (GH)-deficient and healthy adults: influence of GH treatment, gender and fasting. Metabolism 1998; 47: 1514–1519.
  • Matsuoka H, Fors H, Bosaeus I, et al. Changes in body composition and leptin levels during growth hormone (GH) treatment in short children with various GH secretory capacities. Eur J Endocrinol 1999; 140: 35–42.
  • Nørrelund H, Gravholt CH, Englaro P, et al. Increased levels but preserved diurnal variation of serum leptin in GH-deficient patients: lack of impact of different modes of GH administration. Eur J Endocrinol 1998; 138: 644–652.
  • Janssen YJH, Frölich M, Deurenberg P, et al. Serum leptin levels during recombinant human GH therapy in adults with GH deficiency. Eur J Endocrinol 1997; 137: 650–654.
  • Kriström B, Carlsson B, Rosberg S, et al. Short-term changes in serum leptin levels provide a strong metabolic marker for the growth response to growth hormone treatment in children. J Clin Endocrinol Metab 1998; 83: 2735–2741.
  • Scacchi M, Pincelli AI Cavagnini F. Growth hormone in obesity. Int J Obesity 1999; 23: 260–271.
  • Casanueva FF, Dieguez C. Interaction between body composition, leptin and growth hormone status. Baillière’s Clin Endocrinol Metab 1998; 12: 297–314.
  • Bergendahl M, Evans WS, Pastor C, et al. Short-term fasting suppresses leptin and (conversely) activates disorderly growth hormone secretion in midluteal phase women — a clinical research center study. J Clin Endocrinol Metab 1999; 84: 883–894.
  • Tannenbaum GS, Gurd W Lapointe M. Leptin is a potent stimulator of spontaneous pulsatile growth hormone (GH) secretion and the GH response to GH-releasing hormone. Endocrinology 1998; 139: 3871–3875.
  • Vuagnat BAM, Pierroz DD, Lalaoui M, et al. Evidence for a leptin-neuropeptide Y axis for the regulation of growth hormone secretion in the rat. Neuroendocrinology 1998; 67: 291–300.
  • Pardini VC, Victória IMN, Rocha SMV, et al. Leptin levels, b-cell function, and insulin sensitivity in families with congenital and acquired generalized lipoatropic diabetes. J Clin Endocrinol Metab 1998; 83: 503–508.
  • Jaquet D, Khallou E, Lévy-Marchal C, et al. Extremely low values of serum leptin in children with congenital generalized lipoatrophy. Eur J Endocrinol 1999; 140: 107–109.
  • Seip M, Trygstad O. Generalized lipodystrophy, congenital and acquired (lipoatrophy). Acta Paediatr 1996; Suppl 413: 2–28.
  • Robbins DC, Danforth E Jr, Horton ES, et al. The effect of diet on thermogenesis in acquired lipodystrophy. Metabolism 1979; 28: 908–916.
  • Moitra J, Mason MM, Olive M, et al. Life without white fat: a transgenic mouse. Genes Dev 1998; 12: 3168–3181.
  • Leon LR, Gavrilova O, Marcus-Samuels B, et al. Mice lacking white adipose tissue enter torpor during fasting via a leptin-independent mechanism. In press, 1999.
  • Shimomura I, Hammer RE, Richardson JA, et al. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev 1998; 12: 3182–3194.
  • Bursztein S, Elwyn DH, Askanazi J, et al. Energy metabolism, indirect calorimetry, and nutrition. P. 266. Williams & Wilkins, Baltimore, 1989.
  • Jeevanandam M, Begay CK Petersen SR. Plasma leptin levels in trauma patients: effect of adjuvant recombinant human growth hormone in intravenously fed multiple trauma patients. J Parent Ent Nutr 1998; 22: 340–346.
  • Ballinger A, Kelly P, Hallyburton E, et al. Plasma leptin in chronic inflammatory bowel disease and HIV: implications for the pathogenesis of anorexia and weight loss. Clin Sci 1998; 94: 479–483.
  • Grunfeld C, Pang M, Shigenaga JK, et al. Serum leptin levels in the acquired immunodeficiency syndrome. J Clin Endocrinol Metab 1996; 81: 4342–4346.
  • Grinspoon SK, Corcoran C, Miller K, et al. Determinants of increased energy expenditure in HIV-infected women. Am J Clin Nutr 1998; 68: 720–725.
  • Yarasheski KE, Zachwieja JJ, Horgan MM, et al. Serum leptin concentrations in human immunodeficiency virus-infected men with low adiposity. Metabolism 1997; 46: 303–305.
  • Simons JPFHA, Schols AMWJ, Campfield LA, et al. Plasma concentration of total leptin and human lung-cancer-associated cachexia. Clin Sci 1997; 93: 273–277.
  • Wallace AM, Sattar N McMillan DC. Effect of weight loss and the inflammatory response on leptin concentrations in gastrointestinal cancer patients. Clin Cancer Res 1998; 4: 2977–2979.
  • Cederholm T, Arner P Palmblad J. Low circulating leptin levels in protein-energy malnourished chronically ill elderly patients. J Int Med 1997; 242: 377–382.
  • Toth MJ, Gottlieb SS, Fisher ML, et al. Plasma leptin concentrations and energy expenditure in heart failure patients. Metabolism 1997; 46: 450–453.
  • Leyva F, Anker SD, Egerer K, et al. Hyperleptinaemia in chronic heart failure. Relationships with insulin. Eur Heart J 1998; 19: 1547–1551.
  • Cleland JGF, Clark AL. Leptin and cardiac cachexia: marker or mediator? Eur Heart J 1998; 19: 1421–1422.
  • LeGall-Salmon E, Stevens WD Levy JR. Total parenteral nutrition increases serum leptin concentration in hospitalized, undernourished patients. J Parent Ent Nutr 1999; 23: 38–42.
  • Ballauff A, Ziegler A, Emons G, et al. Serum leptin and gonadotropin levels in patients with anorexia nervosa during weight gain. Mol Psychiatry 1999; 4: 71–75.
  • Eckert ED, Pomeroy C, Raymond N, et al. Leptin in anorexia nervosa. J Clin Endocrinol Metab 83: 791–795.
  • Audi L, Mantzoros C, Vidal-Puig A, et al. Leptin in relation to resumption of menses in women with anorexia nervosa. Mol Psychiatry 1998; 3: 544–547.
  • Hebebrand J, Blum WF, Barth N, et al. Leptin levels in patients with anorexia nervosa are reduced in the acute state and elevated upon short-term restoration. Mol Psychiatry 1997; 2: 330–334.
  • Köpp W, Blum WF, von Prittwitz S, et al. Low leptin levels predict amenorrhea in underweight and eating disordered females. Mol Psychiatry 1997; 2: 335–360.
  • Nakai Y, Hamagaki S, Kato S, et al. Leptin in women with eating disorders. Metabolism 1999; 48: 217–220.
  • Warren MP, Voussoughian F, Geer EB, et al. Functional hypothalamic amenorrhea: hypoleptinemia and disordered eating. J Clin Endocrinol Metab 1999; 84: 873–877.
  • Korbonits M. Leptin and the thyroid — a puzzle with missing pieces. Clin Endocrinol 1998; 49: 569–572.
  • Orban Z, Bornstein SR Chrousos GP. The interaction between leptin and the hypothalamic-pituitary-thyroid axis. Horm Metab Res 1998; 30: 231–235.
  • Pinkney JH, Goodrick SJ, Katz J, et al. Leptin and the pituitary-thyroid axis: a comparative study in lean, obese, hypothyroid and hyperthyroid subjects. Clin Endocrinol 1998; 49: 583–588.
  • Leonhardt U, Ritzel U, Schäfer G, et al. Serum leptin levels in hypo- and hyperthyroidism. J Endocrinol 1998; 157: 75–79.
  • Ozata M, Ozisik G, Bingol N, et al. The effect of thyroid status on plasma leptin levels in women. J Endocrinol Invest 1998; 21: 337–341.
  • Yoshida T, Momotani N, Hayashi M, et al. Serum leptin concentrations in patients with thyroid disorders. Clin Endocrinol 1998; 48: 299–302.
  • Diekman MJM, Romijn JA, Endert E, et al. Thyroid hormones modulate serum leptin levels: observations in thyrotoxic and hypothyroid women. Thyroid 1998; 8: 1081–1086.
  • Kautzky-Willer A, Ludwig C, Nowotny P, et al. Elevation of plasma leptin concentrations in obese hyperinsulinaemic hypothyroidism before and after treatment. Eur J Clin Invest 1999; 29: 395–403.
  • Corbetta S, Englaro P, Giambona S, et al. Lack of effects of circulating thyroid hormone levels on serum leptin concentrations. Eur J Endocrinol 1997; 137: 659–663.
  • Sesmilo G, Casamitjana R, Halperin I, et al. Role of thyroid hormones on serum leptin levels. Eur J Endocrinol 1998; 139: 428–430.
  • Liu J, Askari H Dagogo-Jack S. Reproducibility of fasting plasma leptin concentration in lean and obese humans. Endocr Res 1999; 25: 1–10.
  • Ravussin E, Pratley RE, Maffei M, et al. Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med 1997; 3: 238–240.
  • Byrnes SE, Baur LA, Bermingham M, et al. Leptin and total cholesterol are predictors of weight gain in pre-pubertal children. Int J Obesity 1999; 23: 146–150.
  • Folsom AR, Jensen MD, Jacobs DR Jr, et al. Serum leptin and weight gain over 8 years in African American and Caucasian young adults. Obesity Res 1999; 7: 1–8.
  • Harris RBS. Loss of body fat in lean parabiotic partners of ob/ob mice. Am J Physiol 1997; 272: R1809–R1815.
  • Harris RBS. Parabiosis between db/db and ob/ob or db/+ mice. Endocrinology 1999; 140: 138–145.
  • Weigle DS, Hutson AM, Kramer JM, et al. Leptin does not fully account for the satiety activity of adipose tissue-conditioned medium. Am J Physiol 1998; 275: R976–R985.
  • Himms-Hagen J. Brown adipose tissue (BAT): role in energy expenditure and intake. In: Ailhaud G, Guy-Grand B, eds. Progress in obesity research: 8. London: John Libbey, pp. 27–31, 1999.
  • Ozata M, Ozdemir IC Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metabol 1999; 84: 3686–95.
  • Farooqi IS, Jebb SA, Langmack G, et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999; 341: 879–84.
  • Heymsfield SB, Greenberg AS, Fujioka K, et al. Recombinant leptin for weight loss in obese and lean adults. A randomized, controlled, dose-escalation trial. JAMA 1999; 282: 1568–75.

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