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Original Articles

Aloe vera as a Functional Ingredient in Foods

, &
Pages 305-326 | Published online: 17 Mar 2010

REFERENCES

  • Afzal , M. , Ali , M. , Hassan , R. A. H. , Sweedam , N. and Dhami , M. S. I. 1991 . Identification of some prostanoids in Aloe vera extracts . Planta Med. , 57 ( 1 ) : 38 – 40 .
  • Agarwal , O. P. 1985 . Prevention of atheromatous heart disease . Angiology , 36 ( 8 ) : 485 – 492 .
  • Agarwala , O. P. 1997 . Whole leaf aloe gel vs. Standard aloe gel . Drug Cosmet. Ind. , 160 ( 2 ) : 22 – 28 .
  • Ajabnoor , M. A. 1990 . Effect of aloes of blood glucose levels in normal and alloxan diabetic mice . J. Ethnopharmacol. , 28 ( 2 ) : 215 – 220 .
  • Akev , N. and Can , A. 1999 . Separation and some properties of Aloe vera L. leaf pulp lectins . Phytother. Res. , 13 ( 6 ) : 489 – 493 .
  • Akev , N. , Turkay , G. , Can , A. , Gurel , A. , Yildiz , F. , Yardibi , H. , Ekiz , E. E. and Uzun , H. 2007 . Tumor preventive effect of Aloe vera leaf pulp Lectin (Aloctin I) on Ehrlich ascites tumors in mice . Phytother. Res. , 21 : 1070 – 1075 .
  • Akinmoladun , A. C. and Akinloye , O. 2007 . Prevention of the onset of hyperglycaemia by extracts of Aloe barbadensis in rabbits treated with alloxan . African J. Biotechnol. , 6 ( 8 ) : 1028 – 1030 .
  • Anderson , B. C. 1983 . Aloe vera juice: A veterinary medicament? . Comp. Cont. Educ. Pract. , 5 : S364 – S368 .
  • Atherton , P. 1998 . Aloe vera revisited . Brit. J. Phytother. , 4 ( 4 ) : 176 – 183 .
  • Averbeck , B. and Reeh , P. W. 2001 . Interactions of inflammatory mediators stimulating release of calcitonin gene-related peptide substance P and prostaglandin E-2 from isolated rat skin . Neuropharmacology , 40 ( 3 ) : 416 – 423 .
  • Avila , H. , Rivero , J. , Herrera , F. and Fraile , G. 1997 . Cytotoxicity of a low molecular weight fraction from Aloe vera (Aloe barbadensis Miller) gel . Toxicon , 35 ( 9 ) : 1423 – 1430 .
  • Bautista-Pérez , R. , Segura-Cobos , D. and Vázquez-Cruz , B. 2004 . In vitro antibradykinin activity of Aloe barbadensis gel . J. Ethnopharmacol. , 93 ( 1 ) : 89 – 92 .
  • Beppu , H. , Koike , T. , Shimpo , K. , Chihara , T. , Hoshino , M. , Ida , C. and Kuzuya , H. 2003 . Radical-scavenging effects of Aloe arborescens Miller on prevention of pancreatic islet B-cell destruction in rats . J. Ethnopharmacol. , 89 : 37 – 45 .
  • Beppu , H. , Kwai , K. , Shimpo , K. , Chihara , T. , Tamai , I. , Ida , C. , Ueda , M. and Kuzuya , H. 2004 . Studies on the components of Aloe arborescens from Japan – monthly variation and differences due to part and position of the leaf . Biochem. Syst. Ecol. , 32 : 783 – 795 .
  • Beppu , H. , Nagamura , Y. and Fujita , K. 1993 . Hypoglycemic and antidiabetic effects of Aloe arborescens Miller var. natalensis Berger . Phytother. Res. , 7 : S37 – S42 .
  • Beppu , H. , Shimpo , K. , Chihara , T. , Tamai , I. , Nomoto-Yamaji , S. , Ozaki , S. , Ito , S. and Kuzuya , H. 2006a . Inhibitory effects of aloe carboxypeptidase fraction on streptomycin-induced enhancement of vascular permeability in the pancreatic islets . Phytomedicine , 13 ( 1–2 ) : 49 – 60 .
  • Beppu , H. , Shimpo , K. , Chihara , Kaneko , T. , Tamai , I. , Yamaji , S. , Ozaki , S. , Kuzuya , H. and Sonoda , S. 2006b . Antidiabetic effects of dietary administration of Aloe arborescens Miller components on multiple low-dose streptomycin-induced diabetes in mice: investigatioin on hypoglycemic action and systemic absorption dynamics of aloe components . J. Ethnopharmacol. , 103 ( 3 ) : 468 – 477 .
  • Blitz , J. J. , Smith , J. W. and Gerard , J. R. 1963 . Aloe vera gel in peptic ulcer therapy: preliminary report . J. Am. Osteopath. Assoc. , 62 : 731 – 735 .
  • Blumenthal , M. and Milot , B. 2004 . Bioassays for testing activity and bioavailability of botanical products . HerbalGram , 63 : 48 – 51 .
  • Bottenberg , M. M. , Wall , G. C. , Harvey , R. L. and Habib , S. 2007 . Oral Aloe vera-induced hepatitis . Ann. Pharmacother. , 41 ( 10 ) : 1740 – 1943 .
  • Bozzi , A. , Perrin , C. , Austin , S. and Vera , F. A. 2007 . Quality and authenticity of commercial aloe vera gel powders . Food Chem. , 103 ( 1 ) : 22 – 30 .
  • Briggs , C. 1995 . Herbal medicine: Aloe . Can. Pharm. J. , 128 : 48 – 50 .
  • Buenz , E. J. 2008 . Aloin induces apoptosis in Jurkat cells . Toxicol. in vitro , 22 ( 2 ) : 422 – 429 .
  • Bunyapraphatsara , N. , Chansrakaew , W. , Pornchirasilp , S. , Peungvicha , P. and Chokechaijaroenporn , O. 1995 . Antidiabetic effect of fresh and preserved aloe gel . Thai. J. Phytopharmacy , 2 ( 2 ) : 9 – 15 .
  • Bunyapraphatsara , N. , Yongchaiyudha , S. , Rungpitarangsi , V. and Chokechaijaroenporn , O. 1996 . Antidiabetic activity of Aloe vera juice. II Clinical trial in diabetes mellitus patients in combination with glibenclamide . Phytomedicine , 3 ( 3 ) : 245 – 248 .
  • Bush , T. M. , Rayburn , K. S. , Holloway , S. W. , Sánchez-Yamamoto , D. S. , Allen , B. L. Lam , T. 2007 . Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey . Altern. Ther. Health Med. , 13 : 30 – 35 .
  • Canigueral , S. and Vila , R. 1993 . Aloe . Brit. J. Phytother. , 3 : 67 – 75 .
  • Cao , X. L. , Huang , D. F. , Dong , Y. M. , Zhao , H. and Ito , Y. 2007 . Separation of aloins A and B from Aloe vera exudates by high speed countercurrent chromatography . J. Liquid Chromatogr. Rel. Technol. , 30 ( 9–12 ) : 1657 – 1668 .
  • Capasso , F. , Borrelli , F. , Capasso , R. , Di Carlo , G. , Izzo , A. A. , Pinto , L. , Mascolo , N. , Castaldo , S. and Longo , R. 1998 . Aloe in its therapeutic use . Phytother. Res. , 12 : S124 – S127 .
  • Capasso , F. , Izzo , A. A. , Pinto , L. , Bifulco , T. , Vitobello , C. and Mascolo , N. 2000 . Phytotherapy and quality of herbal medicines . Fitoterapia , 71 : S58 – S65 .
  • Cerqueira , L. , McKnight , L. S. , Rodriguez , S. and Turner , C. E. Bifurcated method to process Aloe whole leaf . US Patent 5,923,357 . 1999 .
  • Chalaprawat , M. 1997 . The hypoglycaemic effects of Aloe vera in Thai diabetic patients . J. Clin. Epidemiol. , 50 : 3
  • Chen , S. H. , Lin , K. Y. , Chang , C. C. , Fang , C. L. and Lin , C. P. 2007 . Aloe-emodin-induced apoptosis in human gastric carcinoma cells . Food Chem. Toxicol. , 45 ( 11 ) : 2296 – 2303 .
  • Chithra , P. , Sajithlal , G. B. and Chandrakasan , G. 1998a . Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats . J. Ethnopharmacol. , 59 ( 3 ) : 179 – 186 .
  • Chithra , P. , Sajithlal , G. B. and Chandrakasan , G. 1998b . Influence of Aloe vera on the healing of dermal wounds in diabetic rats . J. Ethnopharmacol. , 59 ( 3 ) : 195 – 201 .
  • Chithra , P. , Sajithlal , G. B. and Chandrakasan , G. 1998c . Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats . Mol. Cell. Biochem. , 181 ( 1–2 ) : 71 – 76 .
  • Choi , S. W. , Son , B. W. , Son , Y. S. , Park , Y. I. , Lee , S. K. and Cheng , M. H. 2001 . The wound-healing effect of a glycoprotein fraction isolated from Aloe vera . Brit. J. Dermatol. , 145 ( 4 ) : 535 – 545 .
  • Chow , J. T. N. , Williamson , D. A. , Yates , K. M. and Goux , W. J. 2005 . Chemical characterization of the immunomodulating polysaccharide of Aloe vera L . Carbohyd. Res. , 340 ( 6 ) : 1131 – 1142 .
  • Coats , B. C. Hypoallergenic stabilized Aloe vera gel . US Patent 4,178,372 . 1979 .
  • Coats , B. C. Method of processing stabilized Aloe vera gel obtained from the whole Aloe vera leaf . US Patent 5,356,811 . 1994 .
  • Cobble , H. H. Stabilized Aloe vera gel . US Patent 3,892,853 . 1975 .
  • Committee Herbal Medicional Products (HMPC) . 2007 . Assessment report on Aloe Barbadensis Miller and Aloe (various species, mainly Aloe Ferox Miller and its hybrids). (Doc. Ref: EMEA/HMPC/76313/2006). Evaluation of Medicines for Human Use , London : European Medicines Agency (EMEA) .
  • Cordella , C. , Moussa , I. , Martel , A.-C. , Sbirrazzuoli , N. and Lizzani-Cuvelier , L. 2002 . Recent developments in food characterization and adulteration detection: Technique-oriented perspectives . J. Agric. Food Chem. , 50 : 1751 – 1764 .
  • Corsi , M. M. , Bertelli , A. A. , Gaja , G. , Fulgenzi , A. and Ferrero , M. E. 1998 . The therapeutic potential of Aloe vera in tumor-bearing rats . Int. J. Tissue Ract. , 20 : 115 – 118 .
  • Danof , I. E. 1987 . Aloe in cosmetics – does it do anything? . Cosmet. Toiletries , 102 : 62 – 63 .
  • Danof , I. E. 1993 . Potential reversal of chronological and photo-aging of the skin by topical application of natural substances . Phytother. Res. , 7 : S53 – S56 .
  • Danof , I. E. and McAnalley , B. H. 1983 . Stabilized Aloe vera - effect on human skin cells . Drug Cosmet. Ind. , 133 : 52, 54, 105 – 106 .
  • Davies , P. , Bailey , P. J. , Goldenberg , M. M. and Fordhutchinson , A. W. 1984 . The role of arachidonic-acid oxygenation products in pain and inflammation . Annu. Rev. Immunol. , 2 : 335 – 357 .
  • Davis , R. H. , Agnew , P. S. and Shapiro , E. 1986 . Antiarthritic activity of anthraquinones found in Aloe for pedriatic medicine . J. Am. Podiat. Med. Assn. , 76 ( 2 ) : 61 – 66 .
  • Davis , R. H. , Donato , J. J. , Hartman , G. M. and Haas , R. C. 1994 . Anti-inflammatory and wound healing activity of a growth substance in Aloe vera . J. Am. Podiat. Med. Assn. , 84 ( 2 ) : 77 – 81 .
  • Davis , R. H. , Kabbani , J. M. and Maro , N. P. 1987 . Aloe vera and wound healing . J. Am. Podiat. Med. Assn. , 77 ( 4 ) : 165 – 169 .
  • Davis , R. H. , Leitner , M. G. , Russo , J. M. and Byrne , M. E. 1989a . Wound healing. Oral and topical activity of Aloe vera . J. Am. Podiat. Med. Assn. , 79 ( 11 ) : 559 – 562 .
  • Davis , R. H. , Leitner , M. G. , Russo , J. M. and Byrne , M. E. 1989b . Anti-inflammatory activity of Aloe vera against a spectrum of irritants . J. Am. Podiat. Med. Assn. , 79 ( 6 ) : 263 – 276 .
  • Davis , R. H. , Rosenthal , K. Y. , Cesario , L. R. and Rouw , G. A. 1989c . Processed Aloe vera administered topically inhibits inflammation . J. Am. Podiat. Med. Assn. , 79 ( 8 ) : 395 – 397 .
  • De Smet , P. A. G. M. 2002 . Drug therapy - Herbal remedies . N. Engl. J. Med. , 347 ( 25 ) : 2046 – 2056 .
  • De Smet , P. A. G. M. 2004 . Health risks of herbal remedies: An update . Clin. Pharmacol. Ther. , 76 ( 1 ) : 1 – 17 .
  • Diehl , B. and Teichmüller , E. E. 1998 . Aloe vera, quality inspection and identification . Agro Food Ind. Hi-Tech , 9 : 14 – 16 .
  • Dominguez-Soto , L. 1992 . Photodermatitis to Aloe vera . Int. J. Dermatol. , 31 ( 5 ) : 372
  • Eberendu , A. R. 2004 . An industry view of the importance of assay development and validation . Inside Lab. Manag. , 4 ( 4 ) : 3
  • Ernst , E. 2000 . Adverse effects of herbal drugs in dermatology . Br. J. Dermatol. , 143 : 923 – 929 .
  • Eshun , K. and He , Q. 2004 . Aloe vera: A valuable ingredient for the food, pharmaceutical and cosmetic industries – A review . CRC Cr. Rev. Food Sci. , 44 : 91 – 96 .
  • Esteban , A. , Zapata , J. M. , Casano , L. , Martín , M. and Sabater , B. 2000 . Peroxidase activity in Aloe barbadensis commercial gel: Probable role in skin protection . Planta Med. , 66 ( 8 ) : 724 – 727 .
  • Esua , M. F. and Rauwald , J. W. 2006 . Novel bioactive maloyl glucans from Aloe vera gel: isolation, structure elucidation and in vitro bioassays . Carbohydr. Res. , 341 : 355 – 364 .
  • European Council . 1988 . Council Directive (EEC) N o 88/388 on the approximation of the laws of the Member States relating to flavourings for use in foodstuffs and to source materials for their production . Official J. Eur. Communities , L188 : 61 – 66 .
  • European Parliament and European Council . 1995 . European Parliament and European Council Directive N o 95/2/EC on food additives other than colours and sweeteners . Official J. Eur. Communities , L61 : 1 – 40 .
  • Federici , E. , Multari , G. , Callo , F. R. and Palazzino , G. 2005 . Herbal drug: from traditional use to regulation . Ann. Ist. Super. Sanita , 41 : 49 – 51 .
  • Femenia , A. , García-Pascual , P. , Simal , S. and Rosselló , C. 2003 . Effects of heat treatment and dehydration on bioactive polysaccharide acemannan and cell wall polymers from Aloe barbadensis Miller . Carbohyd. Polym. , 51 : 397 – 405 .
  • Femenia , A. , Sánchez , E. S. , Simal , S. and Rosselló , C. 1999 . Compositional features of polysaccharides from Aloe vera (Aloe barbadensis Miller) plant tissues . Carbohyd. Polym. , 39 : 109 – 117 .
  • Flaster , T. and Lassiter , J. 2004 . Quality control in herbal preparations: using botanical reference standards for proper identification . HerbalGram , 63 : 32 – 37 .
  • Fogleman , R. W. , Chapdelaine , J. M. , Carpenter , R. H. and McAnalley , B. H. 1992 . Toxicologic evaluation of injectable acemannan in the mouse, rat and dog . Vet. Hum. Toxicol. , 34 ( 3 ) : 201 – 205 .
  • Fox , T. R. 1990 . “ Aloe vera Revered, mysterious healer ” . In Health Food Business 45 – 46 .
  • Franz , G. 1989 . Polysaccharides in pharmacy: current applications and future concepts . Planta Med. , 55 : 493 – 497 .
  • Freytag , E. 1954 . Suggested role of traumatic acid in Aloe wound healing . Pharmazie , 9 : 705
  • Frumkin , A. 1989 . Aloe vera, salicylic acid and aspirin for burns . Plast. Reconstr. Surg. , 83 ( 1 ) : 196
  • Fujita , K. , Teradaira , R. and Nagatsu , H. 1976 . Bradykininase activity of Aloe extract . Biochem. Pharmacol. , 25 : 205 – 206 .
  • Fujita , K. , Ito , S. , Teradaira , R. and Beppu , H. 1979 . Properties of a carboxypeptidase from aloe . Biochem. Pharmacol. , 28 : 1261 – 1262 .
  • Fulton , J. F. Jr. 1990 . The stimulation of postdermabrasion wound healing with stabilized Aloe vera gel-polyethylene oxide dressing . J. Dermatol. Surg. Onc. , 16 ( 5 ) : 460 – 467 .
  • Garifallidi , P. , Hiskia , A. and Calokerinos , A. C. Determination of adulteration in Aloe vera comercial products . 4th Aegean Analytical Chemistry Days . Kusadasi, Turkey.
  • Ghannam , N. , Kingston , M. , Al-Meshaal , I. A. , Tariq , M. , Parman , N. S. and Woodhouse , N. 1986 . The antidiabetic activity of aloes: Preliminary clinical and experimental observations . Horm. Res. , 24 : 288 – 294 .
  • Gjerstad , G. 1971 . Chemical studies of Aloe vera juice. I: Amino acid analysis . Advancing Frontiers Plant Sci. , 28 : 311 – 315 .
  • Gowda , D. C. 1980 . Structural studies of polysaccharides from Aloe saponaria Aloe vanbalenii . Carbohyd. Res. , 83 : 402 – 405 .
  • Gowda , D. C. , Neelisiddaiah , B. and Anjaneyalu , Y. V. 1979 . Structural studies of polysaccharides from Aloe vera . Carbohyd. Res. , 72 : 201 – 205 .
  • Griggs , B. 1996 . “ Aloe, aloe ” . In Country Living 122 – 124 .
  • Grindlay , D. and Reynolds , T. 1986 . The Aloe vera phenomenon: a review of the properties and modern uses of the leaf parenchyma gel . J. Ethnopharmacol. , 16 ( 2–3 ) : 117 – 151 .
  • Gutterman , Y. and Chauser-Volfson , E. 2000 . The distribution of the phenolic metabolites barbaloin, aloeresin and aloenin as a peripheral defense strategy in the succulent leaf parts of Aloe arborescens . Biochem. Syst. Ecol. , 28 ( 9 ) : 825 – 838 .
  • Haddad , P. , Samsami , S. , Ali Oghabian , M. , Amouzgar-Hashemi , F. and Tigmaghz , Z. 2007 . A clinical trial of Aloe vera for prophylaxis of radiation-induced dermatitis . Radiother. Oncol. , 84 : S81 – S81 .
  • Hale , G. 2003 . “ Scope of products containing aloe has broadened ” . In International Aloe Science Council Website http://www.iasc.org/productscope.html
  • He , Q. , Changhong , L. , Kojo , E. and Tian , Z. 2005 . Quality and safety assurance in the processing of aloe vera gel juice . Food Control , 16 : 95 – 104 .
  • Heggers , J. P. , Kucukcelebi , A. , Listengarten , D. , Stabenau , J. , Ko , F. , Broemeling , L. D. , Robson , M. C. and Winters , W. D. 1996 . Beneficial effect of Aloe on wound healing in an excisional wound model . J. Altern. Complem. Med. , 2 ( 2 ) : 271 – 277 .
  • Heggers , J. P. , Kucukcelebi , A. , Stabenau , C. J. , Ko , F. , Broemeling , L. D. , Robson , M. C. and Winters , W. D. 1995 . Wound healing effects of Aloe gel and other topical antibacterial agents on rat skin . Phytother. Res. , 9 : 455 – 457 .
  • Heggers , J. P. , Pelley , R. P. and Robson , M. C. 1993 . Beneficial effects of Aloe in wound healing . Phytother. Res. , 7 : S48 – S52 .
  • Heggie , S. , Bryant , G. P. , Tripcony , L. , Keller , J. , Rose , P. , Glendennig , M. and Heath , J. 2002 . A Phase III study on the efficacy of topical Aloe vera gel on irradiated breast tissue . Cancer Nurs. , 25 ( 6 ) : 442 – 451 .
  • Herlihy , J. T. , Kim , J. D. , Kalu , D. N. , Nelson , J. F. , Ward , W. F. , Ikeno , Y. and Yu , B. P. 1998 . Effects of Aloe vera ingestion in the rat. II. Hormonal and metabolic characteristics . Phytother. Res. , 12 ( 5 ) : 355 – 360 .
  • Hogan , D. J. 1988 . Widespread dermatitis after topical treatment of chronic leg ulcers and statis dermatitis . Can. Med. Assoc. J. , 138 ( 4 ) : 336 – 338 .
  • Hu , Q. H. , Hu , Y. and Xu , J. 2005 . Free radical-scavenging activity of Aloe vera (Aloe barbadensis Miller) extracts by supercritical carbon dioxide extraction . Food Chem. , 91 ( 1 ) : 85 – 90 .
  • Hu , Y. , Xu , J. and Hu , Q. 2003 . Evaluation of antioxidant potential of Aloe vera (Aloe barbadensis Miller) extracts . J. Agric. Food Chem. , 51 ( 26 ) : 7788 – 7791 .
  • Hunter , D. and Frumkin , A. 1991 . Adverse reactions to vitamin E and Aloe vera preparations after dermabrasion and chemical peel . Cutis , 47 ( 3 ) : 193 – 196 .
  • Hutter , J. A. , Salman , M. , Stavinoha , W. B. , Satsangi , N. , Williams , R. F. , Streeper , R. T. and Weintraub , S. T. 1996 . Antiinflammatory C-glucosyl chromone from Aloe barbadensis. . J. Nat. Prod. , 59 ( 5 ) : 541 – 543 .
  • Ikeno , Y. , Cox , R. J. , Uchida , K. and Reddick , R. L. 1998 . Immunohistochemical analysis of lipid peroxidation products and glycated endproducts in aging fischer 344 rat kidneys and modulation by dietary restriction . Free Radical Bio. Med. , 25 : S84
  • Ikeno , Y. , Hubbard , G. B. , Lee , S. , Yu , B. P. and Herlihy , J. T. 2002 . The influence of long-term Aloe vera ingestion on age-related disease in male Fischer 344 rats . Phytother. Res. , 16 ( 8 ) : 712 – 718 .
  • Im , S. A. , Oh , S. T. , Song , S. , Kim , M. R. , Kim , D. S. , Woo , S. S. , Jo , T. H. , Park , Y. I. and Lee , C. K. 2005 . Identification of optimal molecular size of modified Aloe polysaccharides with maximum immunomodulatory activity . Int. J. Immunopharmaco. , 5 ( 2 ) : 271 – 279 .
  • Imanishi , K. and Suzuki , I. 1984 . Augmentation of natural cell-mediated cytotoxic reactivity of mouse lymphoid cells by Aloctin A . Int. J. Immunopharmaco. , 6 : 539 – 543 .
  • Imanishi , K. , Ishiguro , T. , Saito , H. and Suzuki , I. 1981 . Pharmacological studies on a plant lectin, Aloctin A. Part I. Growth inhibition of mouse methylcholanthrene induced fibrosarcoma (Meth A) in ascites form by Aloctin A . Experientia , 37 ( 11 ) : 1186 – 1187 .
  • International Aloe Science Council (IASC) . 2004 . Aloe vera certification criteria , International Aloe Science Council Website . http://www.iasc.org/certcriteria.html
  • Ishii , Y. , Tanizawa , H. and Takino , Y. 1990 . Studies of Aloe III. Mechanism of cathartic effect. (2) . Chem. Pharm. Bull. , 38 ( 1 ) : 197 – 200 .
  • Kar , A. , Panda , S. and Bharti , S. 2002 . Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice . J. Ethnopharmacol. , 81 ( 2 ) : 281 – 285 .
  • Kaufman , T. , Kalderon , N. , Ullman , Y. and Berger , J. 1988 . Aloe vera gel hindered wound healing of experimental second-degree burns: A quantitative controlled study . J. Burn Care Rehabil. , 9 ( 2 ) : 156 – 159 .
  • Kim , H. S. and Lee , B. M. 1997 . Inhibition of benzo[a]pyrene DNA adduct formation by Aloe barbadensis Miller . Carcinogenesis , 18 ( 4 ) : 771 – 776 .
  • Kim , H. S. , Kacew , S. and Lee , B. M. 1999 . In vitro chemopreventive effect of plant polysaccharides (Aloe barbadensis Miller, Lentinis edodes Ganoderma lucidum Coriolus versicolor) . Carcinogenesis , 20 ( 8 ) : 1637 – 1640 .
  • Kim , K. H. , Lee , J. G. , Kim , D. C. , Kim , M. K. , Park , J. H. , Shin , Y. G. , Lee , S. K. , Jo , T. H. and Oh , S. T. 1998 . The development of a new method to detect the adulteration of commercial Aloe gel powders . Arch. Pharm. Res. , 21 ( 5 ) : 514 – 520 .
  • Klein , A. D. and Penneys , N. S. 1988 . Aloe vera . J. Am. Acad. Dermatol. , 18 ( 4 ) : 714 – 720 .
  • Kodym , A. 1991 . The main chemical component contained in fresh leaves and in a dry extract from three years old Aloe arborescens Mill. grown in hothouses . Pharmazie , 46 : 216 – 219 .
  • Kodym , A. , Marcinkowski , A. and Kukula , H. 2003 . Technology of eye drops containing aloe (Aloe arborescens Mill.Liliaceae) and eye drops containing both aloe and neomycin sulphate . Acta Pol. Pharm. , 60 ( 1 ) : 319
  • Koike , T. , Beppu , H. , Kuzuya , H. , Maruta , K. , Shimpo , K. , Suzuki , M. , Titani , K. and Fujita , K. 1995 . A 35 kDa mannose-binding lectin with hemagglutinating and mitogenic activities from ‘Kidachi Aloe’ (Aloe arborescens Miller var. natalensis Berger) . J. Biochem. , 118 ( 6 ) : 1205 – 1210 .
  • Koo , M. W. L. 1994 . Aloe vera: antiulcer and antidiabetic effects . Phytother. Res. , 8 : 461 – 464 .
  • Kupchan , S. M. and Karim , A. 1976 . Tumor inhibitor. 114. Aloe emodin: antileukemic principle isolated from Rhamnus frangula L . Lloydia , 39 ( 4 ) : 223 – 224 .
  • Lachenmeier , K. , Kuepper , U. , Musshoff , F. , Madea , B. , Reusch , H. and Lachenmeier , D. W. 2005 . Quality control of Aloe vera beverages . Electronic J. Environ. Agric. Food Chem. , 4 ( 4 ) : 1 – 12 . http://ejeafche.uvigo.es/4(4)2005/010442005F.htm
  • Langmead , L. , Makins , R. J. and Rampton , D. S. 2004 . Anti-inflammatory effects of Aloe vera gel in human colorectal mucosa in vitro . Aliment. Pharmacol. Ther. , 19 : 521 – 527 .
  • Lawless , J. and Allan , J. 2000 . Aloe vera – Natural wonder cure , London : Harper Collins Publihers, Hammersmith .
  • Lee , A. , Chui , P. T. , Aun , C. S. T. , Gin , T. and La , A. S. C. 2004 . Possible interaction between sevoflurane and Aloe vera . Ann. Pharmacother. , 38 ( 10 ) : 1651 – 1654 .
  • Lee , B. M. and Park , K.-K. 2003 . Beneficial and adverse effects of chemopreventive agents . Mutat. Res. , 523–524 : 265 – 278 .
  • Lee , K. Y. , Weintraub , S. T. and Yu , B. P. 2000 . Isolation and identification of a phenolic antioxidany from Aloe barbadensis . Free Radical Bio. Med. , 28 ( 2 ) : 261 – 265 .
  • Lee , M. J. , Lee , O. H. , Yoon , S. H. , Lee , S. K. , Chung , M. H. , Park , Y. I. , Sung , C. K. , Choi , J. S. and Kim , K. W. 1998 . In vitro angiogenic activity of Aloe vera gel on calf pulmonary artery endothelial (CPAE) cell . Arch. Pharm. Res. , 21 ( 3 ) : 260 – 265 .
  • Leung , A. Y. 1977 . Aloe vera in cosmetics . Drug Cosmet. Ind. , 120 ( 6 ) : 34
  • Leung , M. Y. K. , Liu , C. , Zhu , L. F. , Hui , Y. Z. , Yu , B. and Fung , K. P. 2004 . Chemical and biological characterization of a polysaccharide biological response modifier from Aloe vera L. var. chinensis (Haw.) Berg . Glycobiology , 14 ( 6 ) : 501 – 510 .
  • Li , H. M. , Su , L. H. and Chen , R. Z. 2004 . Simultaneous determination of trace amounts of iron (II), copper (II) and cobalt (II) in aloe by second derivative peak area spectrophotometry . Spectrosc. Spect. Anal. , 24 ( 4 ) : 463 – 465 .
  • Li , J. Y. , Wang , T. X. , Shen , Z. G. and Hu , Z. H. 2003 . Relationship between leaf structure and aloin content in six species of Aloe L . Acta Bot. Sin. , 45 ( 5 ) : 594 – 600 .
  • Lim , B. O. , Seong , N. S. , Choue , R. W. , Kim , J. D. , Lee , H. Y. , Kim , S. Y. , Yu , B. P. , Jeon , T. I. and Park , D. K. 2003 . Efficacy of dietary Aloe vera supplementation on hepatic cholesterol and oxidative status in aged rats . J. Nutr. Sci. Vitaminol. , 49 ( 4 ) : 292 – 296 .
  • Liu , C. H. , Wang , C. H. , Xu , Z. L. and Wang , Y. 2007 . Isolation, chemical characterization and antioxidant activities of two polysaccharides from the gel and the skin of Aloe barbadensis Miller irrigated with sea water . Proc. Biochem. , 42 ( 6 ) : 961 – 970 .
  • Loots , D. T. , van der Westhuizen , F. H. and Botes , L. 2007 . Aloe ferox leaf gel phytochemical content, antioxidant capacity, and possible health benefits . J. Agric. Food Chem. , 55 ( 17 ) : 6891 – 6896 .
  • Luta , G. and McAnalley , B. H. 2005 . Aloe vera: Chemical composition and methods used to determine its presence in comercial products . Glycoscience and Nutrition , 6 ( 4 ) : 1 – 12 .
  • Luyckx , V. A. , Ballantine , R. , Claeys , M. , Cuyckens , F. , van den Heuvel , H. , Cimanga , R. K. , Vlietinck , A. J. , De Broe , M. E. and Katz , I. J. 2002 . Herbal remedy-associated acute renal failure secondary to Cape aloes . Am. J. Kidney Dis. , 39 ( 3 ) : E13
  • Mabusela , W. T. , Stephen , A. M. and Botha , M. C. 1990 . Carbohyd. Polym. from Aloe ferox leaves . Phytochemistry , 29 : 3555 – 3558 .
  • Maenthaisong , R. , Chaiyakunapruk , N. , Niruntraporn , S. and Kongkaew , C. 2007 . The efficacy of Aloe vera used for burn wound healing: A systematic review . Burns , 33 : 713 – 718 .
  • Mandal , G. and Das , A. 1980 . Structure of the glucomannan isolated from Aloe barbadensis Miller . Carbohyd. Res. , 87 : 249 – 256 .
  • Manna , S. and McAnalley , B. H. 1993 . Determination of the position of the O-acetyl group in a beta (1–4) mannan (Acemannan) from Aloe barbadensis Miller . Carbohyd. Res. , 17 ( 241 ) : 317 – 319 .
  • Marshall , G. D. and Druck , J. P. 1993 . In vitro stimulation of NK activity by Acemannan . J. Immunol. , 150 : 241A
  • Marshall , G. D. , Gibbon , A. S. and Parnell , L. S. 1993 . Human cytokines induced by Acemannan . J. Allergy Clin. Immun. , 91 : 241A
  • Marshall , J. M. 1990 . Aloe vera gel: what is the evidence? . Pharm. J. , 244 : 360 – 362 .
  • McAnalley , B. H. Process for preparation of Aloe products, produced thereby and composition thereof . US Patent 4,735,935 . 1988 .
  • McAnalley , B. H. Process for preparation of Aloe products . US Patent No. 4,957,907 . 1990 .
  • McAuliffe , J. C. and Hindsgaul , O. 1997 . Carbohydrate drugs-an ongoing challenge . Chem. Ind. , : 170 – 174 .
  • McCauley , R. L. , Heggers , J. P. and Robson , M. C. 1990 . Frostbite. Methods to minimize tissue loss . Postgrad. Med. , 88 ( 8 ) : 67 – 68 . 73 – 77 .
  • McConaughy , S. D. , Stroud , P. A. , Boudreaux , B. , Hester , R. D. and McCormick , C. L. 2008 . Structural characterization and solution properties of galacturonate polysaccharide derived from Aloe vera capable of in situ gelation . Biomacromolecules , 9 : 472 – 480 .
  • McDaniel , H. R. 1987 . A clinical pilot study using Carrsyn (Aloe vera concentrate) in the treatment of AIDS patients . Am. J. Clin. Pathol. , 88 : 68
  • McDaniel , H. R. , Perkins , S. and McAnalley , B. H. 1987 . A clinical pilot study using Carrsyn in the treatment of aquired immunodeficiency syndrome (AIDS) . Am. J. Clin. Pathol. , 88 : 534
  • McKeown , E. 1987 . Aloe vera . Cosmet. Toiletries , 102 : 64 – 65 .
  • McKeown , E. C. 1983 . Aloe Vera – The quest for the curative missing link . Drug Cosmet. Ind. , : 32 – 33 .
  • Meadows , T. P. 1980 . Aloe as a humectant in new skin preparations . Cosmet. Toiletries , 95 ( 11 ) : 51 – 56 .
  • Merriam , E. A. , Campbell , B. D. , Flood , L. P. , Welsh , C. J. R. , McDaniel , H. R. and Busbee , D. L. 1996 . “ Enhancement of immune function in rodents using a complex plant carbohydrate which stimulates macrophage secretion of immunoreactive cytokines ” . In Advances in Anti-Aging Medicine , Edited by: Klatz , R. M. Vol. 1 , 181 – 203 . Larchmont, New York : Mary Ann Liebert, Inc. .
  • Montaner , J. K. , Gill , J. , Singer , J. , Raboud , J. , Arseneau , R. , McLean , B. D. , Schechter , M. T. and Ruedy , J. 1996 . Double blind placebo-controlled pilot trial of Acemannan in advanced human immunodeficiency virus disease . J. Acq. Immun. Def. Synd. , 12 : 153 – 157 .
  • Moon , E.-J. , Lee , Y. M. , Lee , O.-H. , Lee , M.-J. , Lee , S.-K. , Chung , M.-H. , Park , Y.-I. , Sung , C.-K. , Choi , J.-S. and Kim , K.-W. 1999 . A novel angiogenic factor derived from Aloe vera gel:β -sitosterol, a plant sterol . Angiogenesis , 3 ( 2 ) : 117 – 123 .
  • Morton , J. F. 1961 . Folk uses and commercial exploitation of Aloe leaf pulp . Econ. Bot. , 15 : 311 – 319 .
  • Mossa , J. S. 1985 . A study on the crude antidiabetic drugs used in Arabian folk medicine . Int. J. Crude Drug Res. , 23 : 137 – 145 .
  • Mueller , S. O. and Stopper , H. 1999 . Characterization of the genotoxicity of anthraquinones in mammalian cells . Biochim. Biophys. Acta , 1428 ( 2–3 ) : 406 – 414 .
  • Mueller , S. O. , Stopper , H. and Dekant , W. 1998 . Biotransformation of the anthraquinones emodin and chrysophanol by cytochrome P450 enzymes. Bioactivation to genotoxic metabolites . Drug Metab. Dispos. , 26 ( 6 ) : 540 – 546 .
  • Natow , A. J. 1986 . Aloe vera, fiction or fact . Cutis , 37 ( 2 ) : 106 – 108 .
  • Newton , L. E. 1987 . On the suitability of Kenyan aloes for commercial cultivation . East Africa Nat. Hist. Soc. Bull. , 17 : 5 – 8 .
  • Ni , Y. , Turner , D. , Yates , K. M. and Tizard , I. 2004 . Isolation and characterization of structural components of Aloe vera L. leaf pulp . Int. Immunopharmacol. , 4 ( 14 ) : 1745 – 1755 .
  • Niciforovic , A. , Adzic , M. , Spasic , S. D. and Radojcic , M. B. 2007 . Antitumor effects of a natural anthracycline analog (Aloin) involve altered activity of antioxidant enzymes in HeLaS3 cells . Cancer Biol. Ther. , 6 ( 8 ) : 1200 – 1205 .
  • Northway , R. B. 1975 . Experimental uses of Aloe vera extract in clinical practice . Vet. Med. Sm. Anim. Clin. , 70 ( 1 ) : 89
  • Norton , S. J. , Talesa , V. , Yuan , W. J. and Principato , G. B. 1990 . Glyoxalase I and glyoxalase II from Aloe vera: purification, characterization and comparison with animal glyoxalases . Biochem. Int. , 22 ( 3 ) : 411 – 418 .
  • Okamura , N. , Asai , M. , Hine , N. and Yagi , A. 1996 . High-performance liquid chromatographic determination of phenolic compounds in Aloe species . J. Chromatogr. A , 746 : 225 – 231 .
  • Okyar , A. , Can , A. , Akev , N. , Baktir , G. and Sutlupinar , N. 2001 . Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models . Phytother. Res. , 15 ( 2 ) : 157 – 161 .
  • Ovodova , R. G. , Lapchik , V. F. and Ovodov , Y. S. 1975 . Polysaccharides in Aloe arborescens . Khim. Prir. Soedin. , 11 : 3 – 5 .
  • Paez , A. , Gebre , G. M. , Gonzalez , M. E. and Tschaplinski , T. J. 2000 . Growth, soluble carbohydrates, and aloin concentration of Aloe vera plants exposed to three irradiance levels . Environ. Exp. Bot. , 44 ( 2 ) : 133 – 139 .
  • Park , M. K. , Park , J. H. , Kim , N. Y. , Shin , Y. G. , Choi , Y. S. , Lee , J. G. , Kim , K. H. and Lee , S. K. 1998 . Analysis of 13 phenolic compounds in aloe species by high performance liquid chromatography . Phytochem. Analysis , 9 ( 4 ) : 186 – 191 .
  • Paulsen , B. S. , Fagerheim , E. and Overbye , E. 1978 . Structural studies of the polysaccharides from Aloe plicatilis Miller . Carbohyd. Res. , 60 : 345 – 351 .
  • Payne , J. M. 1970 . Tissue response to Aloe vera gel following periodontal surgery , Thesis submitted to Faculty of Baylor University for the Degree of Master of Science .
  • Pecere , T. , Gazzola , M. V. , Mucignat , C. , Parolin , C. , Vecchia , F. D. , Cavaggioni , A. , Basso , G. , Diaspro , A. , Salvato , B. , Carli , M. and Palu , G. 2000 . Aloe-emodin is a new type of anti-cancer agent with selective activity against neuroectodermal tumors . Cancer Res. , 60 ( 11 ) : 2800 – 2804 .
  • Pelley , R. P. 1992 . Aloe quality control: current of HPLC in the quality control of aloe barbadensis extracts . Aloe Today, (Autumn) , : 19 – 26 .
  • Pelley , R. P. , Wang , Y.-T. and Waller , T. A. 1993 . Current status of quality control of Aloe barbadensis extracts . SOFW Journal , 25 ( 1 ) : 255 – 268 .
  • Pelley , R. P. , Martini , W. J. , Liu , D. Q. , Yang , Z. , Rachui , S. , Li , K. M. , Waller , T. A. and Strickland , F. M. 1998 . Multiparameter analysis of commercial “Aloe vera” materials and comparison of Aloe barbadensis Miller extracts . Subtrop. Plant Sci. , 50 : 1 – 14 .
  • Penneys , N. S. 1982 . Inhibition of arachidonic acid oxidation in vitro by vehicle components . Acta Derm.-Venereol. , 62 : 59 – 61 .
  • Pérez , Y. Y. , Jiménez-Ferrer , E. , Zamilpa , A. , Hernández-Valencia , M. , Alarcón-Aguilar , F. J. , Tortoriello , J. and Román-Ramos , R. 2007 . Effect of polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice . Am. J. Chin. Med. , 36 ( 6 ) : 1037 – 1046 .
  • Pugh , N. , Ross , S. A. , ElSohly , M. A. and Pasco , D. S. 2001 . Characterization of Aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity . J. Agric. Food Chem. , 49 ( 1 ) : 1030 – 1034 .
  • Qiu , Z. , Jones , K. , Wylie , M. , Jia , Q. and Orndorff , S. 2000 . Modified Aloe barbadensis polysaccharide with inmunoregulatory activity . Planta Med. , 66 ( 2 ) : 152 – 156 .
  • Rabe , C. , Musch , A. , Schirmacher , P. , Kruis , W. and Hoffmann , R. 2005 . Acute hepatitis induced by an Aloe vera preparation: A case report . World J. Gastroenterol. , 11 ( 2 ) : 303 – 304 .
  • Rajasekaran , S. , Sivagnanam , K. and Subramanian , S. 2005 . Mineral contents of Aloe vera leaf gel and their role on streptozotocin-induced diabetic rats . Biol. Trace Elem. Res. , 108 ( 1–3 ) : 185 – 196 .
  • Ralamboranto , L. , Rakotovao , L. H. , Le Deaut , J. Y. , Chaussoux , D. , Salomon , J. C. , Fournet , B. , Montreuil , J. , Rakotonirina-Randriambeloma , P. J. , Dulat , C. and Coulanges , P. 1982 . Immunomodulating properties of an extract isolated and partially purified from Aloe vahombe. 3. Study of antitumoral properties and contribution to the chemical nature active principle . Arch. Inst. Pasteur Madagascar , 50 ( 1 ) : 227 – 256 .
  • Rebecca , W. , Kayser , O. , Hagels , H. , Zessin , K.-H. , Madundo , M. and Gamba , N. 2003 . The phytochemical profile and identification of main phenolic compounds from the leaf exudate of Aloe secundiflora by high-performance liquid chromatography-mass spectrometry . Phytochem. Analysis , 14 ( 2 ) : 83 – 86 .
  • Reglamento (CE) N o 258/1997, de 27 de enero (DOCE L 43, de 14 de febrero), sobre nuevos alimentos y nuevos ingredientes alimentarios. Ministerio de Agricultura Pesca y Alimentación. Subdirección General de Planificación Alimentaria
  • Reif , K. , Sievers , H. and Steffen , J.-P. 2004 . The role of chemical reference standards as analytical tools in the quality assessment of botanical materials – An European perspective . HerbalGram , 63 : 38 – 43 .
  • Reynolds , T. 1985 . The compounds of Aloe leaf exudates: a review . Bot. J. Linn. Soc. , 90 : 157 – 77 .
  • Reynolds , T. Aloe vera: what are the active ingredients? . Proceeding of the Active Ingredients Conference . Paris. pp. 85 – 93 .
  • Reynolds , T. and Dweck , A. C. 1999 . Aloe vera leaf: a review update . J. Ethnopharmacol. , 68 ( 1–3 ) : 3 – 37 .
  • Robson , M. C. , Heggers , J. P. and Hagstrom , W. J. 1982 . Myth, magic, withchcraft or fact? Aloe vera revisited . J. Burn Care Rehabil. , 3 : 157 – 163 .
  • Rodriguez , S. 2004 . “ How large is the aloe market? ” . In International Aloe Science Council Website http://www.iasc.org/aloemarket.html
  • Rodríguez-Fragoso , L. , Reyes-Esparza , J. , Burchiel , S. W. , Herrera-Ruiz , D. and Torres , E. 2008 . Risks and benefits of commonly used herbal medicines in Mexico . Toxicol. Appl. Pharmacol. , 227 : 125 – 135 .
  • Román-Ramos , R. , Flores-Saenz , J. L. , Partida-Hernández , G. , Lara-Lemus , A. and Alarcón-Aguilar , F. 1991 . Experimental study of the hypoglycemic effect of some antidiabetic plants . Arch. Invest. Med. , 22 ( 1 ) : 87 – 93 .
  • Rosca-Casian , O. , Parvu , M. , Vlase , L. and Tamas , M. 2007 . Antifungal activity of Aloe vera leaves . Fitoterapia , 78 : 219 – 222 .
  • Ross , S. A. , ElSohly , M. A. and Wilkins , S. P. 1997 . Quantitative analysis of Aloe vera mucilaginous polysaccharide in commercial Aloe vera products . J. AOAC Int. , 80 ( 2 ) : 455 – 457 .
  • Rubel , B. L. 1983 . Possible mechanisms of the healing actions of aloe gel . Cosmet. Toiletries , 98 : 109 – 114 .
  • Sabeh , F. , Wright , T. and Norton , S. J. 1993 . Purification and characterization of a glutathione-peroxidase from the Aloe vera plant . Enzyme Protein , 47 ( 2 ) : 92 – 98 .
  • Sabeh , F. , Wright , T. and Norton , S. J. 1996 . Isozymes of superoxide dismutase from Aloe vera . Enzyme Protein , 49 ( 4 ) : 212 – 221 .
  • Sacc[ugrave] , D. , Bogoni , P. and Procida , G. 2001 . Aloe exudate: Characterization by reversed phase HPLC and headspace GC-MS . J. Agric. Food Chem. , 49 ( 10 ) : 4526 – 4530 .
  • Sahito , S. R. , Kazi , T. G. , Kazi , G. H. , Memon , M. A. , Shaikh , Q. , Jakhrani , M. A. and Shar , G. Q. 2003 . Comparison of sample preparation methods for the determination of essential and toxic elements in important indigenous medicinal plant Aloe barbadensis . J. Chem. Soc. Pakistan , 25 ( 3 ) : 201 – 205 .
  • Saito , H. 1993 . Purification and active substances of Aloe arborescens Miller and their biological and pharmacological activity . Phytother. Res. , 7 : S14 – S19 .
  • Saito , H. , Ishiguro , T. , Imanishi , K. and Suzuki , I. 1982 . Pharmacological studies on a plant lectin Aloctin A. II. Inhibitory effect of Aloctin A on experimental models of inflammation in rats . Jpn. J. Pharmacol. , 32 ( 1 ) : 139 – 142 .
  • Sakai , R. 1989 . Epidemiologic survey on lung cancer with respect to cigarette smoking and plant diet . Jpn. J. Cancer Res. , 80 ( 6 ) : 513 – 520 .
  • Schechter , S. R. 1994 . Aloe vera: the healing plant . Health Foods Business , : 23 – 24 .
  • Schorkhuber , M. , Richter , M. , Dutter , A. , Sontag , G. and Marian , B. 1998 . Effect of anthraquinone−laxatives on the proliferation and urokinase secretion of normal, premalignant and malignant colonic epithelial cells . Eur. J. Cancer , 34 ( 7 ) : 1091 – 1098 .
  • Segal , A. , Taylor , J. A. and Eoff , J. C. 1968 . A re-investigation of polysaccharide material form Aloe vera mucilage . Lloydia , 31 : 423 – 424 .
  • Shahnaz , A. M. A. , Kalhonoz , Z. and Badar , Y. 1993 . Aloe a biologically active and potencial medicinal plant . Hamdard Medicus , 36 ( 1 ) : 108 – 115 .
  • Shapiro , K. and Gong , W. C. 2002 . Natural products used for diabetes . J. Am. Pharm. Assoc. , 42 : 217 – 226 .
  • Shaw , D. , León , C. , Kolev , S. and Murray , V. 1997 . Traditional remedies and food supplements: a 5 –year toxicological study (1991–1995) . Drug Safety , 17 : 342 – 356 .
  • Shelton , R. M. 1991 . Aloe vera. Its chemical and therapeutic properties . Int. J. Dermatol. , 30 ( 10 ) : 679 – 683 .
  • Shoji , A. 1982 . Contact dermatitis to Aloe arborescens . Contact Dermatitis , 8 : 164 – 167 .
  • Silano , M. , De Vicenzi , M. , De Vicenzi , A. and Silano , V. 2004 . The new European legislation on tradicional herbal medicines: man features and perspectivas . Fitoterapia , 75 : 107 – 116 .
  • Simal , S. , Femenía , A. , Llull , P. and Rosselló , C. 2000 . Dehydration of Aloe vera: simulation of drying curves and evaluation of functional properties . J. Food Eng. , 43 : 109 – 114 .
  • Spoerke , D. G. and Elkins , B. R. 1980 . Aloe vera-fact or quackery . Vet. Hum. Toxicol. , 22 ( 6 ) : 418 – 424 .
  • Steemkamp , V. and Stewart , M. J. 2007 . Medical applications and toxicological activities of Aloe products . Pharm. Biol. , 45 ( 5 ) : 411 – 420 .
  • Strickland , F. M. , Muller , H. K. , Stephens , L. C. , Bucana , C. D. , Donawho , C. K. , Sun , Y. and Pelley , R. P. 2000 . Induction of primary cutaneous melanomas in C3H mice by combined treatment with ultraviolet radiation, ethanol and aloe emodin . Photochem. Photobiol. , 72 ( 3 ) : 407 – 414 .
  • Su , H. Y. , Cherng , S. H. , Chen , C. C. and Lee , H. 1995 . Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene . Mutat. Res. , 329 ( 2 ) : 205 – 212 .
  • Sultana , B. and Anwar , F. 2008 . Flavonols (kaempeferol, quercetin, myricetin) contents of selected fruits, vegetables and medicinal plants . Food Chem. , 108 : 879 – 884 .
  • Suvitayavat , W. , Sumrongkit , C. , Thirawarapan , S. S. and Bunyapraphatsara , N. 2004 . Effects of Aloe preparation on the histamine-induced gastric secretion in rats . J. Ethnopharmacol. , 90 ( 2–3 ) : 239 – 247 .
  • Suzuki , I. , Saito , H. , Inoue , S. , Migita , S. and Takahashi , T. 1979 . Purification and characterization of 2 lectins from Aloe-Arborescens Mill . J. Biochem. , 85 ( 1 ) : 163 – 171 .
  • Syed , T. A. , Ahmad , S. A. , Holt , A. H. , Ahmad , S. H. , Ahmad , S. H. and Afzal , M. 1996 . Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-cotrolled, double-blind study . Trop. Med. Int. Health , 1 ( 4 ) : 505 – 509 .
  • t'Hart , L. A. , van den Berg , A. J. , Kuis , L. , van Dijk , H. and Labadie , R. P. 1989 . An anti-complementary polysaccharide with immunological adjuvant activity from the leaf parenchyma gel of Aloe vera . Planta Med. , 55 ( 6 ) : 509 – 512 .
  • Takeyama , E. , Fukushima , M. and Tanimura , A. 2002 . Effect of heat-treatment on the content and polysaccharide composition of dietary fiber . Food Sci. Technol. Res. , 8 ( 2 ) : 125 – 130 .
  • Talmadge , J. , Chavez , J. , Jacobs , L. , Munger , C. , Chinnah , T. , Chow , J. T. , Williamson , D. and Yates , K. 2004 . Fraction of Aloe vera L. inner gel, purification and molecular profiling of activity . Int. J. Immunopharmaco. , 4 ( 14 ) : 1757 – 1773 .
  • Tizard , I. , Carpenter , R. H. , McAnalley , B. H. and Kemp , M. 1989 . The biological activity of mannans andrelated complex carbohydrates . Mol. Biother. , 1 : 290 – 296 .
  • Tsuda , H. , Ito , M. , Hirono , I. , Hawai , K. , Beppu , H. , Fujita , K. and Nagao , M. 1993 . Inhibitory effect of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) on induction of preneoplastic focal lesions in the rat liver . Phytother. Res. , : 43 – 47 . Suppl. 7
  • Umano , K. , Nakahara , K. , Shoji , A. and Shibamoto , T. 1999 . Aroma chemicals isolated and identified from leaves of Aloe arborescens Mill. var. natalensis Berger . J. Agric. Food Chem. , 47 ( 9 ) : 3702 – 3705 .
  • Urch , D. 1999 . Aloe vera – Nature's gift , 7 – 13 . Bristol, , England : Blackdown Publications .
  • Valverde , J. M. , Valero , D. , Martínez-Romero , D. , Guillén , F. , Castillo , S. and Serrano , M. 2004 . Novel edible coating base don Aloe vera gel to maintain table grape quality and safety . J. Agric. Food Chem. , 53 ( 20 ) : 7807 – 7813 .
  • Van Wyk , B. E. , van Oudtshoorn , B. and Gericke , N. 1997 . Medicinal plants of South Africa , Pretoria : Briza Publications .
  • Van Wyk , B. E. , van Rheede van Oudshoorn , M. C. B. and Smith , G. F. 1995 . Geographical variation in the major compounds of Aloe ferox leaf exudate . Planta Med. , 61 ( 3 ) : 250 – 253 .
  • Viljoen , A. M. , Van Wyk , B.-E. and Newton , L. E. 2001 . The occurrence and taxonomic distribution of the anthrones aloin, aloinoside and microdontin in Aloe . Biochem. Syst. Ecol. , 29 ( 1 ) : 53 – 67 .
  • Vogler , B. K. and Ernst , E. 1999 . Aloe vera: a systematic review of its clinical effectiveness . Brit. J. Gen. Pract. , 49 ( 447 ) : 823 – 828 .
  • Wagar , W. A. , Shaukat , S. and Sohalil , T. 2008 . Study of glibenclamide with some traditional herbs used for the treatment of diabetes in Pakistan . J. Chem. Soc. Pakistan , 30 ( 1 ) : 147 – 154 .
  • Waller , G. R. , Mangiafico , S. and Ritchey , C. R. 1978 . A chemical investigation of Aloe barbadensis Miller . Proc. Okla. Acad. Sci. , 58 : 69 – 76 .
  • Wang , D. X. , Yang , G. L. , Wang , L. Y. and Song , X. R. 2000 . Determination of the active components in Clinese herb Aloe vera L. var. chinensis (Haw.) Berger by capillary zone electrophoresis . Se Pu , 18 ( 5 ) : 423 – 425 .
  • Wang , W. , Cuyckens , F. , Van den Heuvel , H. , Apers , S. , Pieters , L. , Steenkamp , V. , Stewart , M. J. , Luyckx , V. A. and Claeys , M. 2003 . Structural characterization of chromone C-glucosides in a toxic herbal remedy . Rapid Commun. Mass Spectrom. , 17 ( 1 ) : 49 – 55 .
  • Wang , Y. T. 1993 . Bases of Aloe certification . Aloe Today , Winter : 27 – 29 .
  • Wang , Y. T. and Strong , K. J. 1993 . Monitoring physical and chemical-properties of freshly harvested field-grown Aloe vera leaves – A preliminary report . Phytother. Res. , 7 : S1 – S4 .
  • Wang , Y. T. and Strong , K. J. 1995 . Two-year study monitoring several physical and chemical properties of field-grown Aloe barbadensis Miller leaves . Subtrop. Plant Sci. , 47 : 34 – 38 .
  • Wang , Y. T. 2007 . Severity of leaf harvest, supplemental nutrients, and sulphur application on long-term leaf production of Aloe barbadensis miller . Hortsci. , 42 ( 7 ) : 1584 – 1588 .
  • Watson , J. B. 1983 . Aloe . Fairchild Trop. Gard. Bull. , 38 : 24 – 28 .
  • Westendorf , J. , Marquardt , H. , Poginskiy , B. , Dominiak , M. , Schmidt , J. and Marquardt , H. 1990 . Genotoxicity of naturally occurring hydroxyanthraquinones . Mutat. Res. , 240 ( 1 ) : 1 – 12 .
  • Winters , W. D. 1991 . Lymphocyte stimulation by newly identified Aloe lectin-mitogens . Adv. New Drug Develop. , 40 : 391 – 397 .
  • Winters , W. D. 1993 . Immunoreactive lectins in leaf gel from Aloe barbadensis Miller . Phytother. Res. , 7 : S23 – S25 .
  • Winters , W. D. and Yang , P. B. 1996 . Polypeptides of the three major medicinal aloes . Phytother. Res. , 10 : 573 – 576 .
  • Winters , W. D. , Benavides , R. and Clouse , W. J. 1981 . Effects of aloe extracts on human normal and tumor cells in vitro . Econ. Bot. , 35 : 89 – 95 .
  • Wolfle , D. , Schumutte , C. , Westendorf , J. and Marquardt , H. 1990 . Hydroxyanthraquinones as tumor promoters: enhancement of malignant transformation of C3H mouse fibroblasts and growth stimulation of primary rat hepatocytes . Cancer Res. , 50 ( 20 ) : 6540 – 6544 .
  • Yagi , A. and Takeo , S. 2003 . Antiinflamatory constituents, aloesin and aloemannan in Aloe species and effects of tanshion VI in Salvia miltiorrhiza on heart . Yakugaku Zasshi , 123 ( 7 ) : 517 – 532 .
  • Yagi , A. , Egusa , T. , Arase , M. , Tanabe , M. and Tsuji , H. 1997 . Isolation and characterization of the glycoprotein with a proliferation promoting activity on human and hamster cell in vitro from Aloe vera gel . Planta Med. , 63 ( 1 ) : 18 – 21 .
  • Yagi , A. , Harada , N. , Yamada , H. , Iwadare , S. and Nishioka , I. 1982 . Antibradykinin active material in Aloe saponaria . J Pharm. Sci. , 71 : 1172 – 1174 .
  • Yagi , A. , Kabash , A. , Mizuno , K. , Moustafa , S. M. , Khalifa , T. I. and Tsuji , H. 2003 . Radical scavenging glycoprotein inhibiting cyclooxygenase 2 and thromboxane A2 synthase from Aloe vera gel . Planta Med. , 69 ( 3 ) : 269 – 271 .
  • Yagi , A. , Kabash , A. , Okamura , N. , Haraguchi , H. , Moustafa , S. M. and Khalifa , T. I. 2002 . Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera . Planta Med. , 68 ( 11 ) : 957 – 960 .
  • Yagi , A. , Machii , K. , Nishimura , H. , Shida , T. and Nishioka , I. 1985 . Effect of Aloe lectin on deoxyribonucleic acid synthesis in baby hamster kidney cells . Experientia , 41 ( 5 ) : 669 – 671 .
  • Yagi , A. , Makino , K. , Nishioka , I. and Kuchino , Y. 1977 . Aloe mannan, polysaccharide, from Aloe arborescens var. natalensis . Planta Med. , 31 ( 1 ) : 17 – 20 .
  • Yagi , A. , Nishimura , H. , Shida , T. and Nishioka , I. 1986 . Structure determination of polysaccharides in Aloe arborescens var. natalensis . Planta Med. , 52 : 213 – 217 .
  • Yamaguchi , I. , Mega , N. and Sanada , H. 1993 . Components of the gel of Aloe vera (L.) burm.f . Biosci. Biotech. Bioch. , 57 ( 8 ) : 1350 – 1352 .
  • Yamamoto , M. , Ishikawa , M. , Masui , T. , Nakazawa , H. and Kabasawa , Y. 1985 . Liquid chromatographic determination of barbaloin (aloin) in foods . J. Assoc. Off. Ana. Chem. , 68 ( 3 ) : 493 – 494 .
  • Yang , Y. , Hou , X. Y. , Wang , S. J. , Jia , Q. L. , Li , Z. and Guo , Z. K. 2004 . Determination of trace zinc, manganese cadmium and lead in aloe by microwave-digestion atomic absorption spectrometry . Spectrosc. Spect. Anal. , 24 ( 12 ) : 1672 – 1675 .
  • Yaron , A. 1991 . Aloe vera: chemical and physical properties and stabilization . Israel J. Bot. , 40 : 270
  • Yaron , A. 1993 . Characterisation of Aloe vera gel composition and autodegradation and stabilization of the natural fresh gel . Phytother. Res. , 7 : S11 – S13 .
  • Yaron , A. , Cohen , E. and Arad , S. M. 1992 . Stabilization of Aloe vera gel by interaction with sulphated polysaccharides from red microalgae and with xantha gum . J. Agric. Food Chem. , 40 ( 8 ) : 1316 – 1320 .
  • Yeh , G. Y. , Eisenberg , D. M. , Kaptchuk , T. J. and Phillips , R. S. 2003 . Systematic review of herbs and dietary supplements for glicemic control in diabetes . Diabetes Care , 26 ( 4 ) : 1277 – 1294 .
  • Yongchaiyudha , S. , Rungpitarangsi , V. , Bunyapraphatsara , N. and Chokechaijaroenporn , O. 1996 . Antidiabetic activity of Aloe vera L. juice. I Clinical trial in new cases of diabetes mellitus . Phytomedicine , 3 ( 3 ) : 214 – 243 .
  • Yoshimoto , R. , Kondoh , N. , Isawa , M. and Hamuro , J. 1987 . Plant lectin, ATF1011, on the tumor cell surface augments tumor-specific immunity through activation of cell T specific for the lectin . Cancer Immunol. Immun.: CII , 25 ( 1 ) : 25 – 30 .
  • Zahn , M. , Trinh , T. , Lee-Jeong , M. , Wang , D. , Abeysinghe , P. , Jia , Q. and Ma , W. 2008 . A reversed-phase high-performance liquid chromatography method for the determination of Aloesin, Aloeresin A and Anthraquinone in Aloe ferox . Phytochem. Anal. , 19 : 122 – 126 .
  • Zawahry , M. E. , Hegazy , M. R. and Helal , M. 1973 . Use of aloe in treating leg ulcers and dermatoses . Int. J. Dermatol. , 12 ( 1 ) : 68 – 73 .
  • Zhang , L. and Tizard , I. R. 1996 . Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel . Inmunopharmacology , 35 ( 2 ) : 119 – 128 .
  • Zhang , X.-F. , Wang , H.-M. , Song , Y.-L. , Nie , L.-H. , Wang , L.-F. , Liu , B. , Shen , P.-P. and Liu , Y. 2006 . Isolation, structure elucidation, antioxidative and immnumodulatory properties of two novel dihydrocoumarins from Aloe vera . Bioorg. Med. Chem. Lett. , 16 : 949 – 953 .
  • Zhou , Y. , Feng , Y. , Wang , H. and Yang , H. 2003 . 90-day subchronic toxicity study of aloe whole-leaf powder . Wei Sheng Yan Jiu , 32 ( 6 ) : 590 – 593 .
  • Zonta , F. , Bogoni , P. , Masotti , P. and Micali , G. 1995 . High-performance liquid chromatographic profiles of aloe constituents and determination of aloin in beverages, with reference to the EEC regulation for flavouring substances . J. Chromatogr. A , 718 ( 1 ) : 99 – 106 .

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