Policosanols as Nutraceuticals: Fact or Fiction

REFERENCES

• Alcocer , L. , Fernandez , L. , Campos , E. and Mas , R. 1999 . A comparative study of policosanol versus acipimox in patients with type II hypercholesterolemia. . Int J Tissue React. , 21 ( 3 ) : 85 – 92 .
   Google Scholar
• Aleman , C. L. , Puig , M. N. , Elias , E. C. , Ortega , C. H. , Guerra , I. R. , Ferreiro , R. M. and Brinis , F. 1995 . Carcinogenicity of policosanol in mice: an 18-month study. . Food Chem Toxicol. , 33 ( 7 ) : 573 – 578 .
   Google Scholar
• Aneiros , E. , Calderon , B. , Mas , R. , Illnait , J. , Castano , G. and Fernandez , C. 1993 . Effect of successive dose increases of policosanol on the lipid profile and tolerability of treatment. . Curr Ther Res Clin Exp. , 54 ( 3 ) : 304 – 312 .
   Google Scholar
• Aneiros , E. , Mas , R. , Calderon , B. , Illnait , J. , Fernandez , L. , Castano , G. and Fernandez , J. C. 1995 . Effect of policosanol in lowering cholesterol levels in patients with type II hypercholesterolemia. . Curr Ther Res Clin Exp. , 56 ( 2 ) : 176 – 181 .
   Google Scholar
• Arruzazabala , M. L. , Carbajal , D. , Mas , R. , Garcia , M. and Fraga , V. 1993 . Effects of Policosanol on platelet aggregation in rats. . Thromb Res. , 69 ( 3 ) : 321 – 327 .
   Google Scholar
• Arruzazabala , M. L. , Molina , V. , Mas , R. , Fernandez , L. , Carbajal , D. , Valdes , S. and Castano , G. 2002 . Antiplatelet effects of policosanol (20 and 40 mg/day) in healthy volunteers and dyslipidaemic patients. . Clin Exp Pharmacol Physiol. , 29 ( 10 ) : 891 – 897 .
   Google Scholar
• Batista , J. , Stusser , R. , Saez , F. and Perez , B. 1996 . Effect of policosanol on hyperlipidemia and coronary heart disease in middle-aged patients. A 14-month pilot study. . Int J Clin Pharmacol Ther. , 34 ( 3 ) : 134 – 137 .
   Google Scholar
• Benitez , M. , Cuauhtemox , R. , Mas , R. , Fernandez , L. and Fernandez , J. 1997 . A comparative study of policosanol versus pravastatin in patients with type II hypercholesterolemia. . Curr Ther Res Clin Exp. , 58 ( 11 ) : 859 – 867 .
   Google Scholar
• Berthold , H. K. , Unverdorben , S. , Degenhardt , R. , Bulitta , M. and Gouni-Berthold , I. 2006 . Effect of policosanol on lipid levels among patients with hypercholesterolemia or combined hyperlipidemia: a randomized controlled trial. . Jama , 295 ( 19 ) : 2262 – 2269 .
   Google Scholar
• Cabrera , L. , Gonzalez , V. , Uribarri , E. , Sierra , R. , Laguna , A. , Magraner , J. , Mederos , D. and Velazquez , C. 2002 . Study of the stability of tablets containing 10 mg of policosanol as active principle. . Boll Chim Farm. , 141 ( 3 ) : 223 – 229 .
   Google Scholar
• Cabrera , L. , Rivero , B. , Magraner , J. , Sierra , R. , Gonzalez , V. , Uribarri , E. , Laguna , A. , Cora , M. , Tejeda , Y. , Rodriguez , E. and Velazquez , C. 2003 . Stability studies of tablets containing 5 mg of policosanol. . Boll Chim Farm. , 142 ( 7 ) : 277 – 284 .
   Google Scholar
• Canetti , M. , Moreira , M. , Illnait , J. , Mas , R. , Fernandez , L. , Fernandez , J. C. and Castano , G. 1995 . One-year study of the effect of policosanol on lipid profile in patients with type II hypercholesterolemia. . Adv Ther. , 12 ( 4 ) : 245 – 254 .
   Google Scholar
• Canetti , M. , Moreira , M. , Mas , R. , Illnait , J. , Fernandez , L. , Fernandez , J. , Diaz , E. and Castano , G. 1995 . A two-year study on the efficacy and tolerability of policosanol in patients with type II hyperlipoproteinaemia. . Int J Clin Pharmacol Res. , 15 ( 4 ) : 159 – 165 .
   Google Scholar
• Carbajal , D. , Arruzazabala , M. L. , Valdes , S. and Mas , R. 1998 . Effect of policosanol on platelet aggregation and serum levels of arachidonic acid metabolites in healthy volunteers. . Prostaglandins Leukot Essent Fatty Acids , 58 ( 1 ) : 61 – 64 .
   Google Scholar
• Castano , G. , Canetti , M. , Moreira , M. , Tula , L. , Mas , R. , Illnait , J. , Fernandez , L. , Fernandez , J. C. and Diaz , E. 1995 . Efficacy and tolerability of policosanol in elderly patients with type II hypercholesterolemia: A 12-month study. . Curr Ther Res Clin Exp. , 56 ( 8 ) : 819 – 828 .
   Google Scholar
• Castano , G. , Fernandez , L. , Mas , R. , Illnait , J. , Fernandez , J. , Mesa , M. , Alvarez , E. and Lezcay , M. 2002 . Comparison of the efficacy, safety and tolerability of original policosanol versus other mixtures of higher aliphatic primary alcohols in patients with type II hypercholesterolemia. . Int J Clin Pharmacol Res. , 22 ( 2 ) : 55 – 66 .
   Google Scholar
• Castano , G. , Fernandez , L. , Mas , R. , Illnait , J. , Mesa , M. and Fernandez , J. C. 2003a . Comparison of the effects of policosanol and atorvastatin on lipid profile and platelet aggregation in patients with dyslipidaemia and type 2 diabetes mellitus. . Clin Drug Investig. , 23 ( 10 ) : 639 – 650 .
   Google Scholar
• Castano , G. , Mas Ferreiro , R. , Fernandez , L. , Gamez , R. , Illnait , J. and Fernandez , C. 2001a . A long-term study of policosanol in the treatment of intermittent claudication. . Angiology , 52 ( 2 ) : 115 – 125 .
   Google Scholar
• Castano , G. , Mas , R. , Arruzazabala , M. L. , Noa , M. , Illnait , J. , Fernandez , J. C. , Molina , V. and Menendez , A. 1999 . Effects of policosanol and pravastatin on lipid profile, platelet aggregation and endothelemia in older hypercholesterolemic patients. . Int J Clin Pharmacol Res. , 19 ( 4 ) : 105 – 116 .
   Google Scholar
• Castano , G. , Mas , R. , Fernandez , J. , Fernandez , L. , Alvarez , E. and Lezcay , M. 2000a . Efficacy and tolerability of policosanol compared with lovastatin in patients with type II hypercholesterolemia and concomitant coronary risk factors. . Curr Ther Res Clin Exp. , 61 ( 3 ) : 137 – 146 .
   Google Scholar
• Castano , G. , Mas , R. , Fernandez , J. C. , Illnait , J. , Fernandez , L. and Alvarez , E. 2001b . Effects of policosanol in older patients with type II hypercholesterolemia and high coronary risk . J Gerontol A Biol Sci Med Sci. , 56 ( 3 ) : M186 – 192 .
   Google Scholar
• Castano , G. , Mas , R. , Fernandez , L. , Fernandez , J. C. , Illnait , J. Lopez , L. E. 2000b . Effects of policosanol on postmenopausal women with type II hypercholesterolemia. . Gynecol Endocrinol. , 14 ( 3 ) : 187 – 195 .
   PubMed Web of Science ®Google Scholar
• Castano , G. , Mas , R. , Fernandez , L. , Illnait , J. , Gamez , R. and Alvarez , E. 2001c . Effects of policosanol 20 versus 40 mg/day in the treatment of patients with type II hypercholesterolemia: a 6-month double-blind study. . Int J Clin Pharmacol Res. , 21 ( 1 ) : 43 – 57 .
   Google Scholar
• Castano , G. , Mas , R. , Fernandez , L. , Illnait , J. , Mendoza , S. , Gamez , R. , Fernandez , J. and Mesa , M. 2005 . A comparison of the effects of D-003 and policosanol (5 and 10 mg/day) in patients with type II hypercholesterolemia: a randomized, double-blinded study. . Drugs Exp Clin Res. , 31 : 31 – 44 .
   PubMedGoogle Scholar
• Castano , G. , Mas , R. , Fernandez , L. , Illnait , J. , Mesa , M. , Alvarez , E. and Lezcay , M. 2003 . Comparison of the efficacy and tolerability of policosanol with atorvastatin in elderly patients with type II hypercholesterolaemia. . Drugs Aging , 20 ( 2 ) : 153 – 163 .
   PubMed Web of Science ®Google Scholar
• Castano , G. , Mas , R. , Nodarse , M. , Illnait , J. and Fernandez , J. C. 1995b . One-year of the efficacy and safety of policosanol (5 mg twice daily) in the treatment of type II hypercholesterolemia. . Curr Ther Res Clin Exp. , 56 ( 3 ) : 296 – 303 .
   Google Scholar
• Castano , G. , Mas , R. , Roca , J. , Fernandez , L. , Illnait , J. , Fernandez , J. C. and Selman , E. 1999 . A double-blind, placebo-controlled study of the effects of policosanol in patients with intermittent claudication. . Angiology , 50 ( 2 ) : 123 – 130 .
   Google Scholar
• Castano , G. , Menendez , R. , Mas , R. , Amor , A. , Fernandez , J. L. , Gonzalez , R. L. , Lezcay , M. and Alvarez , E. 2002 . Effects of policosanol and lovastatin on lipid profile and lipid peroxidation in patients with dyslipidemia associated with type 2 diabetes mellitus . Int J Clin Pharmacol Res. , 22 ( 3–4 ) : 89 – 99 .
   PubMedGoogle Scholar
• Castano , G. , Tula , L. , Canetti , M. , Morera , M. , Mas , R. , Illnait , J. , Fernandez , L. and Fernandez , L. C. 1996 . Effects of policosanol in hypertensive patients with type II hypercholesterolemia. . Curr Ther Res Clin Exp. , 57 ( 9 ) : 691 – 698 .
   Google Scholar
• Cubeddu , L. X. , Cubeddu , R. J. , Heimowitz , T. , Restrepo , B. , Lamas , G. A. and Weinberg , G. B. 2006 . Comparative lipid-lowering effects of policosanol and atorvastatin: a randomized, parallel, double-blind, placebo-controlled trial . Am Heart J. , 152 ( 5 ) : 982 e981 – 985 .
   Google Scholar
• Davis , P. J. and Poznansky , M. J. 1987 . Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by changes in microsomal cholesterol content or phospholipid composition. . Proc Natl Acad Sci U S A , 84 ( 1 ) : 118 – 121 .
   PubMed Web of Science ®Google Scholar
• Dulin , M. F. , Hatcher , L. F. , Sasser , H. C. and Barringer , T. A. 2006 . Policosanol is ineffective in the treatment of hypercholesterolemia: a randomized controlled trial. . Am J Clin Nutr. , 84 ( 6 ) : 1543 – 1548 .
   PubMed Web of Science ®Google Scholar
• Elkind , M. S. 2006 . Inflammation, atherosclerosis, and stroke. . Neurologist , 12 ( 3 ) : 140 – 148 .
   PubMed Web of Science ®Google Scholar
• Francini-Pesenti , F. , Beltramolli , D. , Dall'acqua , S. and Brocadello , F. 2008 . Effect of sugarcane policosanol on lipid profile in primary hypercholesterolemia. . Phytother Res. , 22 ( 3 ) : 318 – 322 .
   Google Scholar
• Gouni-Berthold , I. and Berthold , H. K. 2002 . Policosanol: clinical pharmacology and therapeutic significance of a new lipid-lowering agent. . Am Heart J. , 143 ( 2 ) : 356 – 365 .
   PubMed Web of Science ®Google Scholar
• Greyling , A. , De Witt , C. , Oosthuizen , W. and Jerling , J. C. 2006 . Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects. . Br J Nutr. , 95 ( 5 ) : 968 – 975 .
   PubMed Web of Science ®Google Scholar
• Guyton , A. C. and Hall , J. E. 1996 . “ Chapter 36: Hemostasis and blood coagulation ” . In Textbook of Medical Physiology, , 9th ed. , 463 – 473 . Philadelphia : W. B. Saunders .
   Google Scholar
• Hargrove , J. L. , Greenspan , P. and Hartle , D. K. 2004 . Nutritional significance and metabolism of very long chain fatty alcohols and acids from dietary waxes. . Exp Biol Med (Maywood) , 229 ( 3 ) : 215 – 226 .
   Web of Science ®Google Scholar
• Jones , P. J. , Pencharz , P. B. and Clandinin , M. T. 1985a . Absorption of 13C-labeled stearic, oleic, and linoleic acids in humans: application to breath tests. . J Lab Clin Med. , 105 ( 6 ) : 647 – 652 .
   PubMed Web of Science ®Google Scholar
• Jones , P. J. , Pencharz , P. B. and Clandinin , M. T. 1985b . Whole body oxidation of dietary fatty acids: implications for energy utilization. . Am J Clin Nutr. , 42 ( 5 ) : 769 – 777 .
   Google Scholar
• Kabir , Y. and Kimura , S. 1993 . Biodistribution and metabolism of orally administered octacosanol in rats. . Ann Nutr Metab. , 37 ( 1 ) : 33 – 38 .
   Google Scholar
• Kabir , Y. and Kimura , S. 1995 . Tissue distribution of (8-14C)-octacosanol in liver and muscle of rats after serial administration. . Ann Nutr Metab. , 39 ( 5 ) : 279 – 284 .
   Google Scholar
• Kassis , A. N. and Jones , P. J. 2006 . Lack of cholesterol-lowering efficacy of Cuban sugarcanepolicosanols in hypercholesterolemic persons. . Am J Clin Nutr. , 84 ( 5 ) : 1003 – 1008 .
   Google Scholar
• Kassis , A. N. , Marinangeli , C. P. , Jain , D. , Ebine , N. and Jones , P. J. 2007 . Lack of effect of sugarcanepolicosanol on plasma cholesterol in Golden Syrian hamsters. . Atherosclerosis , 194 ( 1 ) : 153 – 158 .
   PubMed Web of Science ®Google Scholar
• Lin , Y. , Rudrum , M. , van der Wielen , R. P. , Trautwein , E. A. , McNeill , G. , Sierksma , A. and Meijer , G. W. 2004 . Wheat germ policosanol failed to lower plasma cholesterol in subjects with normal to mildly elevated cholesterol concentrations. . Metabolism , 53 ( 10 ) : 1309 – 1314 .
   Google Scholar
• Marinangeli , C. P. , Kassis , A. N. , Jain , D. , Ebine , N. , Cunnane , S. C. and Jones , P. J. 2007 . Comparison of composition and absorption of sugarcane policosanols. . Br J Nutr. , 97 ( 2 ) : 381 – 388 .
   Google Scholar
• Mas , R. 2000 . Policosanol. Hypolipidemic, antioxidant, treatment of atherosclerosis. . Drugs Future , 25 ( 6 ) : 569 – 586 .
   Google Scholar
• Mas , R. , Castano , G. , Illnait , J. , Fernandez , L. , Fernandez , J. , Aleman , C. , Pontigas , V. and Lescay , M. 1999 . Effects of policosanol in patients with type II hypercholesterolemia and additional coronary risk factors. . Clin Pharmacol Ther. , 65 ( 4 ) : 439 – 447 .
   Google Scholar
• Menendez , R. , Amor , A. M. , Rodeiro , I. , Gonzalez , R. M. , Gonzalez , P. C. , Alfonso , J. L. and Mas , R. 2001 . Policosanol modulates HMG-CoA reductase activity in cultured fibroblasts. . Arch Med Res. , 32 ( 1 ) : 8 – 12 .
   Google Scholar
• Menendez , R. , Arruzazabala , L. , Mas , R. , Del Rio , A. , Amor , A. M. , Gonzalez , R. M. , Carbajal , D. , Fraga , V. , Molina , V. and Illnait , J. 1997 . Cholesterol-lowering effect of policosanol on rabbits with hypercholesterolaemia induced by a wheat starch-casein diet. . Br J Nutr. , 77 ( 6 ) : 923 – 932 .
   Google Scholar
• Menendez , R. , Fernandez , S. I. , Del Rio , A. , Gonzalez , R. M. , Fraga , V. , Amor , A. M. and Mas , R. M. 1994 . Policosanol inhibits cholesterol biosynthesis and enhances low density lipoprotein processing in cultured human fibroblasts . Biol Res. , 27 ( 3–4 ) : 199 – 203 .
   Google Scholar
• Menendez , R. , Mas , R. , Amor , A. M. , Gonzalez , R. M. , Fernandez , J. C. , Rodeiro , I. , Zayas , M. and Jimenez , S. 2000 . Effects of policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modification in vitro. . Br J Clin Pharmacol. , 50 ( 3 ) : 255 – 262 .
   Google Scholar
• Menendez , R. , Mas , R. , Amor , A. M. , Rodeiros , I. , Gonzalez , R. M. and Alfonso , J. L. 2001b . Inhibition of cholesterol biosynthesis in cultured fibroblasts by D003, a mixture of very long chain saturated fatty acids. . Pharmacol Res. , 44 ( 4 ) : 299 – 304 .
   Google Scholar
• Mesa , A. R. , Mas , R. , Noa , M. , Hernandez , C. , Rodeiro , I. , Gamez , R. , Garcia , M. , Capote , A. and Aleman , C. L. 1994 . Toxicity of policosanol in beagle dogs: one-year study. . Toxicol Lett. , 73 ( 2 ) : 81 – 90 .
   Google Scholar
• Mirkin , A. , Mas , R. , Martinto , M. , Boccanera , R. , Robertis , A. , Poudes , R. , Fuster , A. , Lastreto , E. , Yanez , M. , Irico , G. , McCook , B. and Farre , A. 2001 . Efficacy and tolerability of policosanol in hypercholesterolemic postmenopausal women. . Int J Clin Pharmacol Res. , 21 ( 1 ) : 31 – 41 .
   PubMedGoogle Scholar
• Murphy , K. J. , Saint , D. A. and Howe , P. R. 2004 . Lack of effect of sugarcaneand sunflower seed policosanols on plasma cholesterol in rabbits . Asia Pac J Clin Nutr. , 13 ( Suppl ) : S69
   Google Scholar
• Ng , C. H. , Leung , K. Y. , Huang , Y. and Chen , Z. Y. 2005 . Policosanol has no antioxidant activity in human low-density lipoprotein but increases excretion of bile acids in hamsters. . J Agric Food Chem. , 53 ( 16 ) : 6289 – 6293 .
   Google Scholar
• Noa , M. , Mas , R. and Mesa , R. 1997 . Effect of policosanol on circulating endothelial cells in experimental models in Sprague-Dawley rats and in rabbits. . J Pharm Pharmacol. , 49 ( 10 ) : 999 – 1002 .
   Google Scholar
• Olivier , L. M. and Krisans , S. K. 2000 . Peroxisomal protein targeting and identification of peroxisomal targeting signals in cholesterol biosynthetic enzymes . Biochim Biophys Acta , 1529 ( 1-3 ) : 89 – 102 .
   PubMed Web of Science ®Google Scholar
• Ortensi , G. , Gladstein , J , Valli , H. and Testone , P. 1997 . A comparative study of policosanol versus simvastatin in elderly patients with hypercholesterolemia. . Curr Ther Res Clin Exp. , 58 ( 6 ) : 390 – 301 .
   Google Scholar
• Pons , P. , Illnait , J. , Mas , R. , Rodriguez , M. , Aleman , C. , Fernandez , J. C. , Fernandez , L. and Martin , M. 1997 . A comparative study of policosanol versus probucol in patients with hypercholesterolemia. . Curr Ther Res Clin Exp. , 58 ( 1 ) : 26 – 35 .
   Google Scholar
• Pons , P. , Mas , R. , Illnait , J. , Fernandez , L. , Rodriguez , M. , Robaina , C. and Fernandez , J. C. 1992 . Efficacy and safety of policosanol in patients with primary hypercholesterolemia. . Curr Ther Res Clin Exp. , 52 ( 4 ) : 507 – 513 .
   Google Scholar
• Pons , P. , Rodriguez , M. , Mas , R. , Illnait , J. , Fernandez , L. , Robaina , C. and Fernandez , J. C. 1994 . One-year efficacy and safety of policosanol in patients with type II hypercholesterolemia. . Curr Ther Res Clin Exp. , 55 ( 9 ) : 1084 – 1092 .
   Google Scholar
• Pons , P. , Rodriguez , M. , Robaina , C. , Illnait , J. , Mas , R. , Fernandez , L. and Fernandez , J. C. 1994 . Effects of successive dose increases of policosanol on the lipid profile of patients with type II hypercholesterolaemia and tolerability to treatment. . Int J Clin Pharmacol Res. , 14 ( 1 ) : 27 – 33 .
   Google Scholar
• Reiner , Z. and Tedeschi-Reiner , E. 2007 . Rice policosanol does not have any effects on blood coagulation factors in hypercholesterolemic patients. . Coll Antropol. , 31 ( 4 ) : 1061 – 1064 .
   Google Scholar
• Reiner , Z. , Tedeschi-Reiner , E. and Romic , Z. 2005 . Effects of rice policosanol on serum lipoproteins, homocysteine, fibringogen and C-reactive protein in hypercholesterolaemic patients. . Clin Drug Invest. , 25 ( 11 ) : 701 – 707 .
   Web of Science ®Google Scholar
• Rodriguez-Echenique , C. , Mesa , R. , Mas , R. , Noa , M. , Menendez , R. , Gonzalez , R. M. , Amor , A. M. , Fraga , V. , Sotolongo , V. and Laguna , A. 1994 . Effects of policosanol chronically administered in male monkeys (Macaca arctoides). . Food Chem Toxicol. , 32 ( 6 ) : 565 – 575 .
   Google Scholar
• Rodriguez , M. D. and Garcia , H. 1998 . Evaluation of peri- and post-natal toxicity of Policosanol in rats. . Teratog Carcinog Mutagen. , 18 ( 1 ) : 1 – 7 .
   Google Scholar
• Sallee , V. L. 1979 . Permeation of long-chain fatty acids and alcohols in rat intestine . Am J Physiol. , 236 ( 6 ) : E721 – 727 .
   Google Scholar
• Sallee , V. L. and Dietschy , J. M. 1973 . Determinants of intestinal mucosal uptake of short- and medium-chain fatty acids and alcohols. . J Lipid Res. , 14 ( 4 ) : 475 – 484 .
   Google Scholar
• Singh , D. K. , Li , L. and Porter , T. D. 2006 . Policosanol inhibits cholesterol synthesis in hepatoma cells by activation of AMP-kinase. . J Pharmacol Exp Ther. , 318 ( 3 ) : 1020 – 1026 .
   Web of Science ®Google Scholar
• Stryer , L. 1995 . “ Chapter 27: Biosyntheis of membrane lipids and steroids ” . In Biochemistry, , 4th ed. , 685 – 712 . New York : W. H. Freeman .
   Google Scholar
• 2002 . Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report . Circulation , 106 ( 25 ) : 3143 – 3421 .
   PubMed Web of Science ®Google Scholar
• ThorneResearch . 2004 . Monograph. Policosanol. . Altern Med Rev. , 9 ( 3 ) : 312 – 317 .
   PubMedGoogle Scholar
• Torres , O. , Agramonte , A. J. , Illnait , J. , Mas Ferreiro , R. , Fernandez , L. and Fernandez , J. C. 1995 . Treatment of hypercholesterolemia in NIDDM with policosanol. . Diabetes Care , 18 ( 3 ) : 393 – 397 .
   PubMed Web of Science ®Google Scholar
• Uribarri , E. , Laguna , A. , Sierra , R. and Ricardo , Y. 2002 . Physico-mechanical characterization of policosanol, a novel hypocholesterolemic drug. . Drug Dev Ind Pharm. , 28 ( 1 ) : 89 – 93 .
   PubMed Web of Science ®Google Scholar
• Wang , Y. , Ebine , N. , Jia , X. , Jones , P. J. , Fairow , C. and Jaeger , R. 2005 . Very long chain fatty acids (policosanols) and phytosterols affect plasma lipid levels and cholesterol biosynthesis in hamsters . Metabolism , 54 ( 4 ) : 508 – 514 .
   Google Scholar
• Wang , Y. W. , Jones , P. J. , Pischel , I. and Fairow , C. 2003 . Effects of policosanols and phytosterols on lipid levels and cholesterol biosynthesis in hamsters. . Lipids , 38 ( 2 ) : 165 – 170 .
   Google Scholar
• Whitcomb , R. W. , Linehan , W. M. and Knazek , R. A. 1988 . Effects of long-chain, saturated fatty acids on membrane microviscosity and adrenocorticotropin responsiveness of human adrenocortical cells in vitro. . J Clin Invest. , 81 ( 1 ) : 185 – 188 .
   PubMed Web of Science ®Google Scholar