Acrylamide: Formation, Occurrence in Food Products, Detection Methods, and Legislation

REFERENCES

• Ahn , J. S. , Castle , L. , Clarke , D. B. , Lloyd , A. S. , Philo , M. R. and Speck , D. R. 2002 . Verification of the findings of acrylamide in heated foods . Food Addit. Contam. , 19 : 1116 – 1124 .
   PubMed Web of Science ®Google Scholar
• Alves , R. C. , Soares , C. , Casal , S. , Fernandes , J. O. , Beatriz , M. and Oliveira , O. O. 2009 . Acrylamide in espresso coffee: Influence of species, roast degree and brew length . Food Chem. , 119 ( 3 ) : 929 – 934 .
   Web of Science ®Google Scholar
• Amrein , T. M. , Andres , L. , Escher , F. and Amado , R. 2007 . Occurrence of acrylamide in selected foods and mitigation options . Food Addit. Contam. , 24 ( 1 ) : 13 – 25 .
   PubMedGoogle Scholar
• Amrein , T. M. , Andres , L. , Schönbächler , B. , Conde-Petit , B. , Escher , F. and Amado , R. 2005a . Acrylamide in almond products . Eur. Food Resourse Technol. , 221 : 14 – 18 .
   Web of Science ®Google Scholar
• Amrein , T. M. , Bachmann , S. , Noti , A. , Biedermann , M. , Ferraz Barbosa , M. , Biedermann-Brem , S. , Grob , K. , Keiser , A. , Realini , P. , Escher , F. and Amadó , R. 2003 . Potential of acrylamide formation, sugars, and free asparagine in potatoes: A comparison of cultivars and farming systems . J. Agric. Food Chem. , 51 : 5556 – 5560 .
   PubMed Web of Science ®Google Scholar
• Amrein , T. M. , Lukac , H. , Andres , L. , Perren , R. , Escher , F. and Amado , R. 2005b . Acrylamide in roasted almonds and hazelnuts . J. Agric. Food Chem. , 53 ( 20 ) : 7819 – 7825 .
   PubMed Web of Science ®Google Scholar
• Amrein , T. M. , Schönbächler , B. , Escher , F. and Amadó , R. 2004 . Acrylamide in gingerbread: Critical factors for formation and possible ways for reduction . J. Agric. Food Chem. , 52 ( 13 ) : 4282 – 4288 .
   PubMed Web of Science ®Google Scholar
• Anese , M. , Suman , M. and Niloli , M. C. 2010 . Acrylamide removal from heated foods . Food Chem. , 119 : 791 – 794 .
   Web of Science ®Google Scholar
• Barutcu , I. , Sahin , S. and Sumnu , G. 2009 . Acrylamide formation in different batter formulations during microwave frying . LWT -Food Sci. Technol. , 42 : 17 – 22 .
   Web of Science ®Google Scholar
• Başkan , S. and Erim , F. B. 2007 . NACE for the analysis of acrylamide in food . Electrophoresis , 28 : 4108 – 4113 .
   PubMed Web of Science ®Google Scholar
• Baum , M. , Bohm , N. , Gorlitz , J. , Lantz , I. , Merz , K. H. , Ternite , R. and Eisenbrand , G. 2008 . Fate of 14C-acrylamide in roasted and ground coffee during storage . Mol. Nutr. Food Resourse , 52 : 600 – 608 .
   PubMed Web of Science ®Google Scholar
• Bermudo , E. , Moyano , E. , Puignou , L. and Galceran , M. T. 2006a . Determination of acrylamide in foodstuffs by liquid chromatography ion-trap tandem mass-spectrometry using an improved clean-up procedure . Anal. Chim. Acta , 559 : 207 – 214 .
   Web of Science ®Google Scholar
• Bermudo , E. , Núňez , O. , Moyano , E. , Puignou , L. and Galceran , M. T. 2006b . Analysis of acrylamide in food samples by capillary zone electrophoresis . J. Chromatogr. A. , 1120 : 199 – 204 .
   PubMed Web of Science ®Google Scholar
• Bermudo , E. , Núňez , O , Moyano , E. , Puignou , L. and Galceran , M. T. 2007 . Field amplified sample injection–capillary electrophoresis–tandem mass spectrometry for the analysis of acrylamide in foodstuffs . J. Chromatogr. A. , 1159 : 225 – 232 .
   PubMed Web of Science ®Google Scholar
• Bermudo , E. , Ruiz-Calero , V. , Puignou , L. and Galceran , M. T. 2004 . Microemulsion electrokinetic chromatography for the analysis of acrylamide in food . Electrophoresis , 25 : 3257 – 3262 .
   PubMed Web of Science ®Google Scholar
• Biedermann , M. , Biedermann-Brem , S. , Noti , A. and Grob , K. 2002a . Methods for determining the potential of acrylamide formation and its elimination in raw materials for food preparation, such as potatoes . Mitt. Lebensmittel Hygiene. , 93 ( 6 ) : 653 – 667 .
   Google Scholar
• Biedermann , M. , Biedermann-Brem , S. , Noti , A. , Grob , K. , Egli , P. and Mandli , H. 2002b . Two GC-MS methods for the analysis of acrylamide in foods . Mitt. Lebensmittel Hygiene. , 93 : 638 – 652 .
   Google Scholar
• Biedermann , M. and Grob , K. 2003 . Model studies on acrylamide formation in potato, wheat flour and corn starch; ways to reduce acrylamide contents in bakery ware . Mitt. Lebensm. Hyg. , 94 ( 5 ) : 406 – 422 .
   Google Scholar
• Biedermann-Brem , S. , Noti , A. , Grob , K. , Imhof , D. , Bazzocco , D. and Pfefferle , A. 2003 . How much reducing sugar may potatoes contain to avoid excessive acrylamide formation during roasting and baking? . Eur. Food Res. Technol. , 217 : 369 – 373 .
   Web of Science ®Google Scholar
• Bjellaas , T. , Stølen , L. H. , Haugen , M. , Paulsen , J. E. , Alexander , J. , Lundanes , E. and Becher , G. 2007 . Urinary acrylamide metabolites as biomarkers for short-term dietary exposure to acrylamide . Food Chem. Toxicol. , 45 : 1020 – 1026 .
   PubMed Web of Science ®Google Scholar
• Bologna , L. S. , Andrawes , F. F. , Barvenik , F. W. , Lentz , R. D. and Sojka , R. E. 1999 . Analysis of residual acrylamide in fried crops . J. Chromatogr. Sci. , 37 : 240 – 244 .
   Web of Science ®Google Scholar
• Boon , P. E. , De Mul , A. , Van Der Voet , H. , Van Donkersgoed , G. , Brette , M. and Van Klaveren , J. D. 2005 . Calculations of dietary exposure to acrylamide . Mutat. Res. , 580 ( 1±2 ) : 143 – 155 .
   PubMedGoogle Scholar
• Bowyer , J. F. , Latendresse , J. R. , Delongchamp , R. P. , Warbritton , A. R. , Thomas , M. , Divine , B. and Doerge , D. R. 2009 . The mRNA expression and histological integrity in rat forebrain motor and sensory regions are minimally affected by acrylamide exposure through drinking water . Toxicol. Appl. Pharmacol. , 240 : 401 – 411 .
   PubMed Web of Science ®Google Scholar
• Bråthen , E. and Knutsen , S. H. 2005 . Effect of temperature and time on the formation of acrylamide in starch-based and cereal model systems, flat breads and bread . Food Chem. , 92 ( 4 ) : 693 – 700 .
   Web of Science ®Google Scholar
• Bråthen , E. B. , Kita , A. , Knutsen , S. H. and Wicklund , T. 2005 . Addition of glycine reduces the content of acrylamide in cereal and potato products . J. Agric. Food Chem. , 53 ( 8 ) : 3259 – 3264 .
   PubMed Web of Science ®Google Scholar
• Brunton , N. P. , Gormley , R. , Butler , F. , Cummins , E. , Danaher , M. , Minihan , M. and O’Keeffe , M. 2007 . A survey of acrylamide precursors in Irish ware potatoes and acrylamide levels in French fries . LWT , 40 : 1601 – 1609 .
   Web of Science ®Google Scholar
• Capuano , E. , Ferrigno , A. , Acampa , I. , Serpen , A. , Açar , Ö. Ç. , Gökmen , V. and Fogliano , V. 2009 . Effect of flour type on Maillard reaction and acrylamide formation during toasting of bread crisp model systems and mitigation strategies . Food Res. Int. , 42 : 1295 – 1302 .
   Web of Science ®Google Scholar
• Carrieri , G , De Bonis , M. V. , Pacella , C. , Pucciarelli , A. and Ruocco , G. 2009 . Modeling and validation of local acrylamide formation in a model food during frying . J. Food Eng. , 95 : 90 – 98 .
   Web of Science ®Google Scholar
• Castle , L. , Campos , M. J. and Gilbert , J. 1991 . Determination of acrylamide monomer in hydroponically grown tomato fruits by capillary gas-chromatography mass-spectrometry . J. Sci. Food Agri. , 54 : 549 – 555 .
   Web of Science ®Google Scholar
• Cavalli , S. , Maurer , R. and Hofler , F. 2003 . “ Fast determination of acrylamide in food samples using accelerated solvent extraction followed by ion chromatography with UV or MS detection ” . 9 – 11 . LC-GC Europe
   Google Scholar
• Central Intercollegiate Athletic Association (CIAA) . 2004 . “ A summary of the efforts and progress achieved to date by the European Food and Drink Industry (CIAA) in lowering levels of acrylamide in food. Acrylamide status report December 2004 ” . Accessed from http://www.ciaaa.be
   Google Scholar
• Chen , F. , Yuan , Y. , Liu , J. , Zhao , G. and Xu , H. 2008 . Survey of acrylamide levels in chinese foods . Food Addit. Contam., B , 1 ( 2 ) : 85 – 92 .
   PubMed Web of Science ®Google Scholar
• Cheng , W. C. , Kao , Y. M. , Shih , D. Y. C. , Chou , S. S. and Yen , A. I. 2009 . Validation of an improved LC/MS/MS method for acrylamide analysis in foods . J. Food Drug Anal. , 17 ( 3 ) : 190 – 197 . +231.
   Web of Science ®Google Scholar
• Chuang , W. H. , Chiu , C. P. and Chen , B. H. 2007 . Analysis and formation of acrylamide in French fries and chicken legs during frying . J. Food Biochem. , 30 ( 5 ) : 497 – 507 .
   Web of Science ®Google Scholar
• Ciesarovát , Z. , Kukurová , K. , Bednáriková , A. , Marková , L. and Baxa , L. 2009 . Improvement of cereal product safety by enzymatic way of acrylamide mitigation . Czech J. Food Sci. , 27 : 96 – 98 .
   Google Scholar
• Claus , A. , Carle , R. and Schieber , A. 2008 . Acrylamide in cereal products: A review . J. Cereal Sci. , 47 : 118 – 133 .
   Web of Science ®Google Scholar
• Cummins , E. , Butler , F. , Gormley , R. and Brunton , N. 2008 . A methodology for evaluating the formation and human exposure to acrylamide through fried potato crisps . LWT , 41 : 854 – 867 .
   Web of Science ®Google Scholar
• Dabrio , M. , Sejeroe-Olsen , B. , Musser , S. , Emteborg , H. , Ulberth , F. and Emons , H. 2008 . Production of a certified reference material for the acrylamide content in toasted bread . Food Chem. , 110 : 504 – 511 .
   Web of Science ®Google Scholar
• De Vleeschouwer , K. , Van der Plancken , I. , Van Loey , A. and Hendrickx , M. E. 2009 . Modelling acrylamide changes in foods: From single response empirical to multiresponse mechanistic approaches . Trends Food Sci. Technol. , 20 : 155 – 167 .
   Web of Science ®Google Scholar
• Dybing , E. , Farmer , P. B. , Andersen , M. , Fennell , T. R. , Lalljle , S. P. D. , Muller , D. J. G. , Olin , S. , Peterson , B. J. , Schlatter , J. , Scholz , G. , Scimeca , J. A. , Slimani , N. , Törnqvist , M. , Tuijtelaars , S. and Verger , P. 2005 . Human exposure and internal dose assessments of acrylamide in food . Food and Chem. Toxicol. , 43 : 365 – 410 .
   PubMed Web of Science ®Google Scholar
• Dybing , E. and Sanner , T. 2003 . Risk Assessment of Acrylamide in Foods . Toxicol. Sci. , 75 : 7 – 15 .
   PubMed Web of Science ®Google Scholar
• Eerola , S. , Hollebekkers , K. , Hallikainen , A. and Peltonen , K. 2007 . Acrylamide levels in Finnish foodstuffs analysed with liquid chromatography tandem mass spectrometry . Mol. Nutr. Food Resourse , 51 : 239 – 247 .
   PubMed Web of Science ®Google Scholar
• Ehling , S. , Hengel , M. and Shibamoto , T. 2005 . Formation of acrylamide from lipids . Adv. Exp. Med. Biol. , 561 : 223 – 233 .
   PubMed Web of Science ®Google Scholar
• Elmore , J. S. , Koutsidis , G. , Dodson , A. T. , Mottram , D. S. and Wedzicha , B. L. 2005 . Measurement of acrylamide and its precursors in potato, wheat, and rye model systems . J. Agric. Food Chem. , 53 ( 4 ) : 1286 – 1293 .
   PubMed Web of Science ®Google Scholar
• Eriksson , S. and Karlsson , P. 2006 . Alternative extraction techniques for analysis of acrylamide in food: Influence of pH and digestive enzymes . LWT Food Sci. Technol. , 39 : 393 – 399 .
   Web of Science ®Google Scholar
• EU . 2003 . “ Information on Ways to Lower the Levels of Acrylamide Formed in Food ” . Note of the Meeting of Experts on Industrial Containments in Food: Acrylamide Workshop 20–21 October, available from http://europa.eu/food/food/chemical-safety/contaminants/acryl_guidance.pdf. Accessed September 15, 2009
   Google Scholar
• FAO/WHO . 2002a . “ Consultation on the Health Implications of Acrylamide in Food Geneva. ” . Accessed 25–27 June 2002
   Google Scholar
• FAO/WHO . 2002b . “ Health Implications of Acrylamide in Food ” . Report of a Joint FAO/WHO Consultation., Report nr.: World Health Organization, Geneva, Switzerland, available at http://www.who.int/foodsafety/publications/chem/en/acrylamide_full.pdf
   Google Scholar
• FDA . 2004 . in http://www.cfsan.fda.gov/~lrd/pestadd.html#acrylamide. Accessed on June 15, 2012
   Google Scholar
• Fernades , J. O. and Soares , S. 2007 . Application of matrix solid-phase dispersion in the determination of acrylamide in potato chips . J. Chromatogr. A. , 1175 : 1 – 6 .
   PubMed Web of Science ®Google Scholar
• Fohgelberg , P. , Rosén , J. , Hellenäs , K. E. and Abramsson-Zetterberg , L. 2005 . The acrylamide intake via some common baby food for children in Sweden during their first year of life—an improved method for analysis of acrylamide . Food Chem. Toxicol. , 43 : 951 – 959 .
   PubMed Web of Science ®Google Scholar
• Font , G. , José Ruiz , M. , Fernández , M. and Picó , M. 2008 . Application of capillary electrophoresis-mass spectrometry for determining organic food contaminants and residues . Electrophoresis , 29 : 2059 – 2078 .
   PubMed Web of Science ®Google Scholar
• Food Standards Agency (FSA) . 2002 . FDA Acrylamide Study: Your Questions Answered , London , , UK : Food Standards Agency . http://www.foodstandards.gov.uk/multimedia/webpage/acrylamide_study_faq/Available from
   Google Scholar
• Foot , R. J. , Haase , N. U. , Grob , K. and Gondé , P. 2007 . Acrylamide in fried and roasted potato products: A review on progress in mitigation . Food Additives and Contaminants, Supplement 1 , 24 ( 1 ) : 37 – 46 .
   PubMedGoogle Scholar
• Franke , K. , Strijowski , U. and Reimerdes , E. H. 2009 . Kinetics of acrylamide formation in potato powder . J. Food Eng. , 90 : 135 – 140 .
   Web of Science ®Google Scholar
• Fuster , M. , Lampi , A. , Hopia , A. and Kamal-Eldin , A. 1998 . Lipids , 33 : 715 – 722 .
   PubMed Web of Science ®Google Scholar
• Geng , Z. , Jiang , R. and Chen , M. 2008 . Determination of acrylamide in starch-based foods by ion-exclusion liquid chromatography . J. Food Compos. Anal. , 21 : 178 – 182 .
   Web of Science ®Google Scholar
• Gerendás , J. , Heuser , F. and Sattelmacher , B. 2007 . Influence of nitrogen and potassium supply on contents of acrylamide precursors in potato tubers and on acrylamide accumulation in French fries . J. Plant Nutr. , 30 : 1499 – 1516 .
   Web of Science ®Google Scholar
• Gertz , C. and Klostermann , S. 2002 . Analysis of acrylamide and mechanisms of its formation in deep-fried products . Eur. J. Lipid Sci. Technol. , 104 : 762 – 771 .
   Web of Science ®Google Scholar
• Gertz , C. , Klostermann , S. and Kochhar , S. P. 2003 . Deep frying: The role of water from food being fried and acrylamide formation . OCL , 10 : 297 – 303 .
   Google Scholar
• Gianni , S. , Armando , F. , Gabriella , M. , Massimo , R. , Sauro , V. and Sergio , A. 2007 . HPLC–MS validation of QualisaFoo® biosensor kit for cost-effective control of acrylamide levels in Italian coffee . Food Control , 18 : 1267 – 1271 .
   Web of Science ®Google Scholar
• Gökmen , V. , Morales , F. J. , Ataç , B. , Serpen , A. and Arribas-Lorenzo , G. 2009 . Multiple-stage extraction strategy for the determination of acrylamide in foods . J. Food Compos. Anal. , 22 : 142 – 147 .
   Web of Science ®Google Scholar
• Gökmen , V. and Şenyuva , H. V. 2006a . Study of colour and acrylamide formation in coffee, wheat flour and potato chips during heating . Food Chem. , 99 : 238 – 243 .
   Web of Science ®Google Scholar
• Gökmen , V. and Şenyuva , H. Z. 2006b . A generic method for the determination of acrylamide in thermally processed foods . J. Chromatogr. A. , 1120 : 194 – 198 .
   PubMed Web of Science ®Google Scholar
• Gökmen , V. , Şenyuva , H. Z. , Dülek , B. and Çetin , E. 2006 . Computer vision based analysis of potato chips – A tool for rapid detection of acrylamide level . Mol. Nutr. Food Resourse , 50 : 805 – 810 .
   PubMed Web of Science ®Google Scholar
• Govaert , Y. , Arisseto , A. , Van Loco , J. , Scheers , E. , Fraselle , S. , Weverbergh , E. , Degroodt , J. M. and Goeyens , L. 2006 . Optimisation of a liquid chromatography–tandem mass spectrometric method for the determination of acrylamide in foods . Anal. Chim. Acta , 556 : 275 – 280 .
   Web of Science ®Google Scholar
• Graf , M. , Amrein , T. M. , Graf , S. , Szalay , R. , Escher , F. and Amadó , R. 2005 . Reducing the acrylamide content of a semi-finished biscuit on industrial scale . Food Sci. Technol. , 39 ( 7 ) : 724 – 728 .
   Google Scholar
• Granby , K. and Fagt , S. 2007 . Analysis of acrylamide in coffee and dietary exposure to acrylamide from coffee . Anal. Chim. Acta. , 520 : 177 – 182 .
   Google Scholar
• Granda , C. , Moreira , R. G. and Tichy , S. E. 2004 . Reduction of acrylamide and mechanisms of its formation in deep-fried products . Eur. J. Lipid Sci. Technol. , 104 : 762 – 771 .
   Web of Science ®Google Scholar
• Granvogl , M. , Jezussek , M. , Koehler , P. and Schieberle , P. 2004 . Quantitation of 3-aminopropionamide in potatoes-A minor but potent precursor in acrylamide formation . J. Agric. Food Chem. , 52 ( 15 ) : 4751 – 4757 .
   PubMed Web of Science ®Google Scholar
• Grob , K. , Biedermann , M. , Biedermann-Brem , S. , Noti , A. , Imhof , D. , Amrein , T. and Prefferle , A. 2003 . French fries with less than 100 g/kg acrylamide. A collaboration between cooks and analysts . Eur. Food Resour. Technol. , 217 : 185 – 194 .
   Web of Science ®Google Scholar
• Grothe , K. , Unbehend , G. , Haase , N. U. , Ludewig , H. G. , Matthäus , B. and Vosmann , K. 2005 . Einflussvon backtriebmitteln auf die acrylamidgehalte von braunen lebkuchen und MuÈrbekeksen (in German) . Getreidetechnologie , 59 ( 3 ) : 163 – 167 .
   Google Scholar
• Guenther , H. , Anklam , E. , Wenzl , T. and Stadler , R. H. 2007 . Acrylamide in coffee: Review of progress in analysis, formation and level reduction . Food Additives and Contaminants, Supplement 1 , 24 ( 1 ) : 60 – 70 .
   PubMedGoogle Scholar
• Haase , N. U. , Matthäus , B. and Vosmann , K. 2003 . Acrylamid in Backwaren - ein Sachstands- bericht (in German) . Getreide Mehl Brot , 57 ( 3 ) : 180 – 184 .
   Google Scholar
• Habermann , C. E. 1991 . E.Kirk-Other Encyclopedia of Chemical Technology , 4th edn , Edited by: Kroschwitz , J. J. and Howe-Grant , M. Vol. 1 , 251 – 266 . New York : Wiley, J., and Sons .
   Google Scholar
• Halford , N. G. , Muttucumaru , N. , Curtis , T. Y. and Parry , M. A. J. 2007 . Genetic and agronomic approaches to decreasing acrylamide precursors in crop plants . Food Addit. Contam. , 24 ( 1 ) : 26 – 36 .
   PubMedGoogle Scholar
• Halle , I. , Ihling , M. , Lahrseen-Wiederholt , M. , Klaffke , H. and Flachowsky , G. 2006 . Carry-over of acrylamide from feed (heated potato product) to eggs and body tissues of laying hens . J. fur Verbraucherschutz und Lebensmittelsicherheit , 1 ( 4 ) : 290 – 293 .
   Google Scholar
• Hedegaard , R. V. , Granby , K. , Frandsen , H. , Thygesen , J. and Skibsted , L. H. 2008 . Acrylamide in bread. EVect of prooxidants and antioxidants . Eur. Food Resourse Technol. , 227 : 519 – 525 .
   Web of Science ®Google Scholar
• Hodge , J. E. 1967 . “ Origin of flavor in foods: Nonenzymatic browning reactions ” . In Chemistry and Physiology of Flavors , Edited by: Schultz , H. W. , Day , E. A. and Libbey , L. M. 465 – 491 . Westport : AVI Publ. .
   Google Scholar
• Hoenicke , K. , Gatermann , R. , Harder , W. and Hartig , L. 2004 . Analysis of acrylamide in different foofstuffs using liquid chromatography-tandem mass spectrometry and gas chromatography-tandem mass spectrometry . Anal. Chim. Acta. , 520 : 207 – 215 .
   Web of Science ®Google Scholar
• Högy , P. and Fangmeier , A. 2009 . Atmospheric CO2 enrichment affects potatoes: 2. Tuber quality traits . Eur. J. Agron. , 30 : 85 – 94 .
   Web of Science ®Google Scholar
• Hurrell , R. F. 1982 . “ Maillard reaction in flavor ” . In Food Flavors , Edited by: Morton , I. D. and MacLeod , A. J. 399 – 437 . Amsterdam : Elsevier .
   Google Scholar
• International Food Safety Authorities Network (INFOSAN) . 2005 . “ Acrylamide in food is a potential health hazard ” . Available from http://www.who.int/foodsafety/fs_management/en/No_02_Acrylamide_Mar05_en.pdf
   Google Scholar
• JECFA . 2005 . Rome Summary and conclusions of the 64th Meeting of the Joint FAO/WHO Expert Meeting on Food Additives
   Google Scholar
• Jensen , B. B. B. , Lennox , M. , Granby , K. and Adler-Nissen , J. 2008 . Robust modelling of heat-induced reactions in an industrial food production process exemplified by acrylamide generation in breakfast cereals . Food Bioproducts Processing , 86 : 154 – 162 .
   Web of Science ®Google Scholar
• Jung , M. Y. , Choi , D. S. and Ju , J. W. 2003 . A novel technique for limitation of acrylamide formation in fried and baked corn chips and in French fries . J. Food Sci. , 68 : 1287 – 1290 .
   Web of Science ®Google Scholar
• Kaplan , O. , Kaya , G. , Ozcan , C. , Ince , M. and Yaman , M. 2009 . Acrylamide concentrations in grilled foodstuffs of Turkish kitchen by high performance liquid chromatography-mass spectrometry . Microchem. J. , 93 : 173 – 179 .
   Web of Science ®Google Scholar
• Kawamura , S. 1983 . “ #x0060;Seventy years of the Maillard reaction ” . In The Maillard Reaction in Foods and Nutrition , Edited by: Waller , G. R. and Feather , M. S. 3 – 18 . Washington , DC : American Chemical Society .
   Google Scholar
• Kim , C. T. , Hwang , E. S. and Lee , H. J. 2005 . Reducing acrylamide in fried snack products by adding amino acids . J. Food Sci. , 70 ( 5 ) : 354 – 358 .
   Google Scholar
• Klaffke , H. , Fauhl , C. , Mathar , W. , Palavinskas , R. , Wittkowski , R. , Wenzl , T. and Anklam , E. 2005 . Results from two interlaboratory comparison tests organized in Germany and at the EU level for analysis of acrylamide in food . J. AOAC Int. , 88 : 292 – 298 .
   PubMed Web of Science ®Google Scholar
• Knol , J. J. , Viklund , G. A. I. , Linssen , J. P. H. , Sjoholm , I. M. , Skog , K. I. and van Boekel , M. A. J. S. 2008 . A study on the use of empirical models to predict the formation of acrylamide in potato crisps . Mol. Nutr. Food Resourse , 52 : 313 – 321 .
   PubMed Web of Science ®Google Scholar
• Knol , J. J. , Viklund , G. A. I. , Linssen , J. P. H. , Sjoholm , I. M. , Skog , K. I. and Van Boekel , M. A. J. S. 2009 . Kinetic modelling: A tool to predict the formation of acrylamide in potato crisps . Food Chem. , 113 : 103 – 109 .
   Web of Science ®Google Scholar
• Knutsen , S. H. , Dimitrijevic , S. , Molteberg , E. L. , Segtnan , V. H. , Kaaber , L. and Wicklund , T. 2009 . The influence of variety, agronomical factors and storage on the potential for acrylamide formation in potatoes grown in Norway . LWT-Food Sci. Technol. , 42 : 550 – 556 .
   Web of Science ®Google Scholar
• Kotretsou , S. I. and Koutsodimou , A. 2006 . Overview of the applications of tandem mass spectrometry (MS/MS) in food analysis of nutritionally harmful compounds . Food Rev. Int. , 22 : 125 – 172 .
   Google Scholar
• Krajewska , A. , Radecki , J. and Radecka , H. 2008 . A voltammetric biosensor based on glassy carbon electrodes modified with single-walled carbon nanotubes/hemoglobin for detection of acrylamide in water extracts from potato crisps . Sensors , 8 ( 9 ) : 5832 – 5844 .
   Web of Science ®Google Scholar
• Kukurová , K. , Ciesarová , Z. , Bednáriková , A. and Marková , L. 2009 . Effect of inorganic salts on acrylamide formation in cereal matrices . Czech J. Food Sci. , 27 : 425 – 428 .
   Google Scholar
• Lantz , I. , Ternite , R. , Wilkens , J. , Hoenicke , K. , Guenther , H. and Stegen , G. H. D. 2006 . Studies on acrylamide levels in roasting, storage and brewing of coffee . Mol. Nutr. Food Resourse , 50 : 1039 – 1046 .
   PubMed Web of Science ®Google Scholar
• Lee , M. R. , Chang , L. Y. and Dou , J. 2007 . Determination of acrylamide in food by solid-phase microextraction coupled to gas chromatography–positive chemical ionization tandem mass spectrometry . Anal. Chim. Acta. , 582 : 19 – 23 .
   PubMed Web of Science ®Google Scholar
• Levine , R. A. and Smith , R. E. 2005 . Sources of variability of acrylamide levels in a cracker model . J. Agric. Food Chem. , 53 ( 11 ) : 4410 – 4416 .
   PubMed Web of Science ®Google Scholar
• Lukac , H. , Amrein , T. M. , Perren , R. , Conde-Petit , B. , Amado , R. and Escher , F. 2007 . Influence of roasting conditions on the acrylamide content and the color of roasted almonds . J. Food Sci. , 72 ( 1 ) : 33 – 38 .
   PubMed Web of Science ®Google Scholar
• Matthäus , B. , Haase , N. U. and Vosmann , K. 2004 . Factors affecting the concentration of acrylamide during deep-fat-frying of potatoes . Eur. J. Lipid Sci. Technol. , 106 : 793 – 801 .
   Web of Science ®Google Scholar
• Mauron , J. 1981 . “ The Maillard reaction in food: A critical review from the nutritional standpoint. ” . In Maillard Reactions in Food , Edited by: Eriksson , C. 3 – 35 . Oxford : Pergamon Press .
   Google Scholar
• Mestdagh , F. , De Wilde , T. , Fraselle , S. , Govaert , Y. , Oogne , W. , Degroodt , J. M. , Verhé , R. , Van Peteghem , C. and De Meulenaer , B. 2008a . Optimization of the blanching process to reduce acrylamide in fried potatoes . LWT-Food Sci. Technol. , 41 : 1648 – 1654 .
   Web of Science ®Google Scholar
• Mestdagh , F. , Maertens , J. , Cucu , T. , Delporte , K. , Van Peteghem , C. and De Meulenaer , B. 2008b . Impact of additives to lower the formation of acrylamide in a potato model system through pH reduction and other mechanisms . Food Chem. , 107 : 26 – 31 .
   Web of Science ®Google Scholar
• Mizukami , Y. , Kohata , K. , Yamaguchi , Y. , Hayashi , N. , Sawai , Y. , Chuda , Y. , Ono , H. , Yada , H. and Yoshida , M. 2006 . Analysis of acrylamide in green tea by gas chromatography-mass spectrometry . J. Agric. Food Chem. , 54 ( 19 ) : 7370 – 7377 .
   PubMed Web of Science ®Google Scholar
• Mizukami , Y. , Sawai , Y. and Yamaguchi , Y. 2008 . Changes in the concentrations of acrylamide, selected odorants, and catechins caused by roasting of green tea . J. Agric. Food Chem. , 56 ( 6 ) : 2154 – 2159 .
   PubMed Web of Science ®Google Scholar
• Mottram , D. S. 1994 . “ Flavour compounds formed during the Maillard reaction ” . In Thermally Generated Flavors: Maillard, Microwave, and Extrusion Processes , Edited by: Parliament , T. H. , Morello , M. J. and McGorrin , R. J. 104 – 126 . Washington , DC : American Chemical Society .
   Google Scholar
• Mottram , D. S. , Wedzicha , B. L. and Dodson , A. T. 2002 . Acrylamide is formed in the Maillard reaction . Nature , 419 ( 6906 ) : 448 – 449 .
   PubMed Web of Science ®Google Scholar
• Mucci , LA. , Dickman , P. W. , Steineck , G. , Adami , H. O. and Augustsson , K. 2003 . Dietary aclylamide and cancer of the large bowel, kidney and bladder: Absence of an association in a population-based study in Sweden . Br. J. Cancer , 88 : 84 – 89 .
   PubMed Web of Science ®Google Scholar
• Murkonic , M. and Derler , K. 2006 . Analysis of amino acids and carbohydrates in green coffee . J. Biochem. Biophys. Methods , 69 : 25 – 32 .
   PubMedGoogle Scholar
• Mustafa , A. , Andersson , R. , Rosén , J. , Kamal-Eldin , A. and Åman , P. 2005 . Factors influencing acrylamide content and color in rye crisp bread . J. Agric. Food Chem. , 53 ( 15 ) : 5985 – 5989 .
   PubMed Web of Science ®Google Scholar
• Mustafa , A. , Fink , M. , Kamal-Eldin , A. , Rosen , J. , Andersson , R. and Aman , P. 2009 . Interaction effects of fermentation time and added asparagine and glycine on acrylamide content in yeast-leavened bread . Food Chem. , 112 : 767 – 774 .
   Web of Science ®Google Scholar
• Nemoto , S. , Takatsuki , S. , Sasaki , K. and Maitani , T. 2002 . Determination of acrylamide in foods by GC/MS using C-13-labeled acrylamide as an internal standard . J. Food Hygiene Soc. Japan , 43 : 371 – 376 .
   PubMed Web of Science ®Google Scholar
• Nursten , H. E. 1980 . Recent developments in studies of the Maillard reaction . Food Chem. , 6 : 263 – 277 .
   Web of Science ®Google Scholar
• Nursten , H. E. 2005 . The Maillard Reaction , Cambridge : Royal Society of Chemistry . http://www.rsc.org/ebooks/archive/free/BK9780854049646/BK9780854049646-FP001.pdfAvailable from
   Google Scholar
• Ono , H. , Chuda , Y. , Ohnishi-Kameyama , M. , Yada , H. , Ishizaka , M. , Kobayashi , H. and Yoshida , M. 2003 . Analysis of acrylamide by LC-MS/MS and GC-MS in processed Japanese foods . Food Additives Contaminants , 20 : 215 – 220 .
   PubMed Web of Science ®Google Scholar
• Owen , L. M. , Castle , L. , Kelly , J. , Wilson , L. A. and Lloyd , A. S. 2005 . Acrylamide analysis: Assessment of results from six rounds of food analysis performance assessment scheme (FAPAS) proficiency testing . J. AOAC Int. , 88 : 285 – 291 .
   PubMed Web of Science ®Google Scholar
• Paleologos , E. K. and Kontominas , M. G. 2005 . Determination of acrylamide and methacrylamide by normal phase high performance liquid chromatography and UV detection . J. Chromatogr. A. , 1077 : 128 – 135 .
   PubMed Web of Science ®Google Scholar
• Paleologos , E. K. and Kontominas , M. G. 2007 . Effect of processing and storage conditions on the generation of acrylamide in precooked breaded chicken products . J. Food Protect. , 70 ( 2 ) : 466 – 470 .
   PubMed Web of Science ®Google Scholar
• Pardo , O. , Yusa , V. , Coscolla , C. , Leon , N. and Pastor , A. 2007 . Determination of acrylamide in coffee and chocolate by pressurised fluid extraction and liquid chromatography–tandem mass spectrometry . Food Addit. Contam. , 24 ( 7 ) : 663 – 672 .
   PubMed Web of Science ®Google Scholar
• Pedreschi , F. , Kaack , K. and Granby , K. 2008 . The effect of asparaginase on acrylamide formation in French fries . Food Chem. , 109 : 386 – 392 .
   PubMed Web of Science ®Google Scholar
• Pittet , A. , Périsset , A. and Oberson , J. M. 2004 . Trace level determination of acrylamide in cereal-based foods by gas chromatography–mass spectrometry . J. Chromatogr. A. , 1035 : 123 – 130 .
   PubMed Web of Science ®Google Scholar
• Pouillart , P. , Mauprivez , H. , Ait-Amer , L. , Cayzeele , A. , Leserf , J. M. , Tessier , F. J. and Birlouez-Aragon , I. 2008 . Strategy for the study of the health impact of dietary Maillard products in clinical studies: The example of the ICARE clinical study on healthy adults . Ann. New York Acad. Sci. , 1126 : 173 – 176 .
   PubMed Web of Science ®Google Scholar
• Preston , A. , Fodey , T. and Elliott , C. 2008 . Development of a high-throughput enzyme-linked immunosorbent assay for the routine detection of the carcinogen acrylamide in food, via rapid derivatisation pre-analysis . Anal. Chim. Acta. , 60 ( 8 ) : 178 – 185 .
   Google Scholar
• Riediker , S. and Stadler , R. H. 2003 . Analysis of acrylamide in food by isotope-dilution liquid chromatography coupled with electrospray ionization tandem mass spectrometry . J. Chromatogr. A. , 1020 : 121 – 130 .
   PubMed Web of Science ®Google Scholar
• Robledo , V. R. and Smyth , W. F. 2009 . The application of CE-MS in the trace analysis of environmental pollutants and food contaminants . Electrophoresis , 30 ( 10 ) : 1647 – 1660 .
   PubMed Web of Science ®Google Scholar
• Romani , S. , Bacchiocca , M. , Rocculi , P. and Dalla Rosa , M. 2008 . Effect of frying time on acrylamide content and quality aspects of French fries . Eur. Food Resourse Technol. , 226 : 555 – 560 .
   Web of Science ®Google Scholar
• Romani , S. , Bacchiocca , M. , Rocculi , P. and Dalla Rosa , M. 2009 . Influence of frying conditions on acrylamide content and other quality characteristics of French fries . J. Food Compos. Anal. , 22 : 582 – 588 .
   Web of Science ®Google Scholar
• Rommens , C. M. , Yan , H. , Swords , K. , Richael , C. and Ye , J. 2008 . Low-acrylamide French fries and potato chips . Plant Biotechnol. J. , 6 : 843 – 853 .
   PubMed Web of Science ®Google Scholar
• Rosén , J. and Hellenäs , K. E. 2002 . Analysis of acrylamide in cooked foods by liquid chromatography tandem mass spectrometry . Analyst , 127 : 880 – 882 .
   PubMed Web of Science ®Google Scholar
• Rufián-Henares , J. , Delgado-Andrade , C. and Morales , F. J. 2006 . Relationship between acrylamide and thermalprocessing indexes in commercial breakfast cereals: A survey of Spanish breakfast cereals . Mol. Nutr. Food Resourse , 50 : 756 – 762 .
   PubMed Web of Science ®Google Scholar
• Rufián-Henares , J. A. and Morales , F. J. 2006 . Determination of acrylamide in potato chips by a reversed-phase LC–MS method based on a stable isotope dilution assay . Food Chem. , 97 : 555 – 562 .
   Web of Science ®Google Scholar
• Rydberg , P. , Eriksson , S. , Tareke , E. , Karlsson , P. , Ehrenberg , L. and Törnqvist , M. 2003 . Investigations of factors that influence the acrylamide content of heated foodstuffs . J. Agric. Food Chem. , 51 : 7012 – 7018 .
   PubMed Web of Science ®Google Scholar
• Sadd , P. and Hamlet , C. 2005 . The formation of acrylamide in UK cereal products . Adv. Exp. Med. Biol. , 561 : 415 – 429 .
   PubMed Web of Science ®Google Scholar
• SCF . 2002 . “ Opinion of the Scientific Committee on Food on new findings regarding the presence of acrylamide in food, Report no. SCF/CS/CNTM/CONT/4 Final ” . Brussels : European Commission .
   Google Scholar
• Şenyuva , H. Z. and Gökmen , V. 2005 . Study of acrylamide in coffee using an improved liquid chromatography mass spectrometry method: Investigation of colour changes and acrylamide formation in coffee during roasting . Food Addit. Contam. , 22 ( 3 ) : 214 – 220 .
   PubMed Web of Science ®Google Scholar
• Sheng , Q. , Zou , H. C. , Lu , Z. R. , Zou , F. , Park , Y. D. , Yan , Y. B. and Yao , S. J. 2009 . Effects of acrylamide on the activity and structure of human brain creatine kinase . Int. J. Mol. Sci. , 10 : 4210 – 4222 .
   PubMed Web of Science ®Google Scholar
• Shih , F. F. , Boue , S. M. , Daigle , K. W. and Shih , B. Y. 2004 . Effects of flour sources on acrylamide formation and oil uptake in fried batters . J. Am. Oil Chem. Soc. , 81 : 265 – 268 .
   Web of Science ®Google Scholar
• Simó , C. , Elvira , C. , González , N. , San Román , J. , Barbas , C. and Cifuentes , A. 2004 . Capillary electrophoresis-mass spectrometry of basic proteins using a new physically adsorbed polymer coating. Some applications in food analysis . Electrophoresis , 25 ( 13 ) : 2056 – 2064 .
   PubMed Web of Science ®Google Scholar
• Skog , K. , Viklund , G. , Olsson , K. and Sjöholm , I. 2008 . Acrylamide in home-prepared roasted potatoes . Mol. Nutr. Food Resourse , 52 : 307 – 312 .
   PubMed Web of Science ®Google Scholar
• Slayne , M. A. and Lineback , D. R. 2005 . Acrylamide: Considerations for risk management . J. AOAC Int. , 88 ( 1 ) : 227 – 233 .
   PubMed Web of Science ®Google Scholar
• Soares , S. and Fernades , J. O. 2009 . MSPD method to determine acrylamide in food . Food Anal. Methods , 2 ( 3 ) : 197 – 203 .
   Web of Science ®Google Scholar
• Springer , M. , Fischer , T. , Lehrack , A. and Freund , W. 2003 . Acrylamidbildung in Backwaren (in German) . Getreide Mehlzund Brot , 57 ( 5 ) : 274 – 278 .
   Google Scholar
• Stadler , R. H. , Blank , I. , Varga , N. , Robert , F. , Hau , J. , Guy , P. A. , Robert , M. C. and Riediker , S. 2002 . Acrylamide from Maillard reaction products . Nature , 419 : 449 – 450 .
   PubMed Web of Science ®Google Scholar
• Stobiecka , A. , Rabecka , H. and Radecki , J. 2007 . Novel voltammetric biosensor for determining acrylamide in food samples . Biosens. Bioelectron. , 22 : 2165 – 2170 .
   PubMed Web of Science ®Google Scholar
• Summa , C. A. , De la Calle , B. , Brohee , M. , Stadler , R. H. and Anklam , E. 2007 . Impact of the roasting degree of coffee on the in vitro radical scavenging capacity and content of acrylamide . Lebensm. Wiss. Technol. , 40 : 1849 – 1854 .
   Google Scholar
• Surdyk , N. , Rosén , J. , Andersson , R. and Åman , P. 2004 . Effects of asparagine, fructose, and baking conditions on acrylamide content in yeast-leavened wheat bread . J. Agric. Food Chem. , 52 ( 7 ) : 2047 – 2051 .
   PubMed Web of Science ®Google Scholar
• Swiss Federal Office of Public Health (BAG) . 2004 . “ Acrylamide: Two years of scrutiny. ” . 41 – 42 . Annual report on food safety 2003. Available from http://www.bag.admin.ch/verbrau/e/index.htm.
   Google Scholar
• Taeymans , D. , Wood , J. , Ashby , P. , Blank , I. , Studer , A. , Stadler , R. H. , Gonde , P. , Van Eijck , P. , Lalljie , S. , Lingnert , H. , Lindblom , M. , Matissek , R. , Muller , D. , Tallmadge , D. , O’Brien , J. , Thompson , S. , Silvani , D. and Whitmore , T. 2004 . A review of acrylamide: An industry perspective on research, analysis, formation, and control . Crit. Rev. Food Sci. Nutr. , 44 : 323 – 347 .
   PubMed Web of Science ®Google Scholar
• Tareke , E. , Rydberg , P. , Karlsson , P. , Eriksson , S. and Törnqvist , M. 2000 . Acrylamide: A Cooking Carcinogen? . Chem. Res. Toxicol. , 13 : 517 – 522 .
   PubMed Web of Science ®Google Scholar
• Tareke , E. , Rydberg , P. , Karlsson , P. , Eriksson , S. and Törnqvist , M. 2002 . Analysis of acrylamide, a carcinogen formed in heated foodstuffs . J. Agric. Food Chem. , 50 ( 17 ) : 4998 – 5006 .
   PubMed Web of Science ®Google Scholar
• Taubert , D. , Harlfinger , S. , Henkes , L. , Berkels , R. and Schomig , E. 2004 . Influence of processing parameters on acrylamide formation during frying of potatoes . J. Agric. Food Chem. , 52 : 2735 – 2739 .
   PubMed Web of Science ®Google Scholar
• Tawfik , M. S. and El-Ziney , M. G. 2008 . Acrylamide levels in selected foods in Saudi Arabia with reference to health-risk assessment of dietary acrylamide intake . Am. J. Food Technol. , 3 ( 6 ) : 347 – 353 .
   Google Scholar
• Tezcan , F. and Erim , F. B. 2008 . On-line stacking techniques for the nonaqueous capillary electrophoretic determination of acrylamide in processed food . Anal. Chim. Acta. , 617 : 196 – 199 .
   PubMed Web of Science ®Google Scholar
• United States Food and Drug Administration (USFDA) . 2004 . Acrylamide in Foods , Washington , DC : United States Food and Drug Administration . Available from http://www.cfsan.fda.gov/~lrd/pestadd.html#acrylamide
   Google Scholar
• Vass , M. , Amrein , T. M. , Schönbächler , B. , Escher , F. and Amadó , R. 2004 . Ways to reduce the acrylamide formation in cracker products . Czech J. Food Sci. , 22 ( special issue ) : 19 – 21 .
   Google Scholar
• Weber , E. A. , Koller , W. D. , Graeff , S. , Hermann , W. , Merkt , N. and Claupein , W. 2008 . Impact of different nitrogen fertilizers and an additional sulfur supply on grain yield, quality, and the potential of acrylamide formation in winter wheat . J Plant Nutr Soil Sci. , 171 : 643 – 655 .
   Web of Science ®Google Scholar
• Weisshaar , R. 2004 . Acrylamid in Backwaren-Ergebnisse von Modellversuchen (in German) . Dtsch. Lebensm.-Rundsch. , 100 ( 3 ) : 92 – 97 .
   Google Scholar
• Wenzl , T. and Anklam , E. 2005 . Evaluation of results of an interlaboratory comparison test on determination of acrylamide in crispbread samples . J. AOAC Int. , 88 : 1413 – 1418 .
   PubMed Web of Science ®Google Scholar
• Yaylayan , V. A. , Wnorowski , A. and Locas , C. P. 2003 . Why asparagine needs carbohydrates to generate acrylamide . J. Agric. Food Chem. , 51 ( 6 ) : 1753 – 1757 .
   PubMed Web of Science ®Google Scholar
• Yusa , V. , Quintás , G. , Pardo , O. , Martí , P. and Pastor , A. 2006 . Determination of acrylamide in foods by pressurized fluid extraction and liquid chromatography-tandem mass spectrometry used for a survey of Spanish cereal-based foods . Food Addit. Contam. , 23 ( 3 ) : 237 – 244 .
   PubMed Web of Science ®Google Scholar
• Zeng , X. , Cheng , K. W. , Jiang , Y. , Lin , Z. X. , Shi , J. J. , Ou , S. Y. , Chen , F. and Wang , M. 2009 . Inhibition of acrylamide formation by vitamins in model reactions and fried potato strips . Food Chem. , 116 : 34 – 39 .
   Web of Science ®Google Scholar
• Zhang , Y. , Dong , Y. , Ren , Y. and Zhang , Y. 2006 . Rapid determination of acrylamide contaminant in conventional fried foods by gas chromatography with electron capture detector . J. Chromatogr. A. , 1116 : 209 – 216 .
   PubMed Web of Science ®Google Scholar
• Zhang , Y. , Ren , Y. , Zhao , H. and Zhang , Y. 2007 . Determination of acrylamide in Chinese traditional carbohydrate-rich foods using gas chromatography with micro-electron capture detector and isotope dilution liquid chromatography combined with electrospray ionization tandem mass spectrometry . Anal. Chim. Acta. , 584 : 322 – 332 .
   PubMed Web of Science ®Google Scholar
• Zhang , Y. , Xu , W. , Wu , X. , Zhang , X. and Zhang , Z. 2007 . Addition of antioxidant from bamboo leaves as an effective way to reduce the formation of acrylamide in fried chicken wings . Food Addit. Contam. , 24 ( 3 ) : 242 – 251 .
   PubMed Web of Science ®Google Scholar
• Zhao , R. , Shao , B. , Zhao , J. , Wu , Y. , Wu , G. and Xue , Y. 2005 . Determination of acrylamide in heated starchy food by liquid chromatography-electrospray ionization tandem mass spectrometry . Chin. J. Chromatography (Se Pu) , 23 ( 3 ) : 289 – 291 .
   Google Scholar
• Zhong , W. , Chen , D. , Yong , W. , Liu , Z. , Qiu , Y. and Tang , Y. 2005 . Determination of acrylamide in fried starchy foods by gas chromatography-mass spectrometry . Chinese Journal of Chromatography (Se Pu) , 23 ( 3 ) : 312 – 314 .
   Google Scholar
• Zhu , F. , Cai , Y. Z. , Ke , J. and Corke , H. 2009 . Evaluation of the effect of plant extracts and phenolic compounds on reduction of acrylamide in an asparagine/glucose model system by RP-HPLC-DAD . J. Sci. Food Agric. , 89 ( 10 ) : 1674 – 1681 .
   Web of Science ®Google Scholar
• Zhu , Y. , Li , G. , Duan , Y. , Chen , S. , Zhang , C. and Li , Y. 2008 . Application of the standard addition method for the determination of acrylamide in heat-processed starchy foods by gas chromatography with electron capture detector . Food Chem. , 109 ( 4 ) : 899 – 908 .
   PubMed Web of Science ®Google Scholar