Resveratrol in Peanuts

References

• Abert-Vian , M. , Tomao , V. , Gallet , S. , Coulomb , P. O. and Lacomb , J. M. 2005 . Simple and rapid method for cis- and trans-resveratrol and piceid isomers determination in wine by high performance liquid chromatography using chromolith columns . J. Chromagr. A. , 1085 : 224 – 229 .
   PubMed Web of Science ®Google Scholar
• Adhami , V. M. , Afaq , F. and Ahmad , N. 2001 . Involvement of the retinoblastoma (pRb)-E2F/DP pathway during antiproliferative effects of resveratrol in human epidermoid carcinoma (A431) cells . Biochem. Biophys. Res. Commun. , 288 : 579 – 585 .
   PubMed Web of Science ®Google Scholar
• Adrian , M. , Jeandet , P. , Bessis , R. and Joubert , J. M. 1996 . Induction of phytoalexin (resveratrol) synthesis in grapevine leaves treated with aluminum chloride (AlCl3) . J. Agric. Food Chem. , 44 : 1979 – 1981 .
   Web of Science ®Google Scholar
• Aguamah , G. E. , Langcake , P. , Leworthy , D. P. , Page , J. A. , Pryce , R. J. and Strange , R. N. 1981 . Two novel stilbene phytoalexins from Arachis hypogaea . Phytochemistry , 20 : 1381 – 1383 .
   Web of Science ®Google Scholar
• Arora , M. K. and Strange , R. N. 1991 . Phytoalexin accumulation in groundnuts in response to wounding . Plant Sci. , 78 : 157 – 163 .
   Web of Science ®Google Scholar
• Azpilicueta , C. E. , Zawoznik , M. S. and Tomaro , M. L. 2004 . Phytoalexins synthesis is enhanced in groundnut plants inoculated with Bradyrhizobium sp. (Arachis) . Crop Prot. , 23 : 1069 – 1074 .
   Web of Science ®Google Scholar
• Bais , A. J. , Murphy , P. J. and Dry , I. B. 2000 . The molecular regulation of stilbene phytoalexin biosynthesis in Vitis vinifera during grape berry development . Aust. J. Plant Physiol. , 27 : 425 – 433 .
   Google Scholar
• Baur , J. A. , Pearson , K. J. , Price , N. L. , Jamieson , H. A. , Lerin , C. , Kaira , A. , Prabhu , V. V. , Allard , J. S. , Lopez-Lluch , G. , Lewis , K. , Pistell , P. J. , Poosala , S. , Becker , K. G. , Boss , O. , Gwinn , D. , Wang , M. , Ramaswany , S. , Fishbein , K. W. , Spencer , R. G. , Lakatta , E. G. , Le Couteur , D. , Shaw , R. J. , Navas , P. , Puigserver , P. , Ingram , D. K. , de Cabo , R. and Sinclair , D. A. 2006 . Resveratrol improves health and survival of mice on a high calorie diet . Nature. , 444 ( 7117 ) : 280 – 285 .
   PubMed Web of Science ®Google Scholar
• Bavaresco , L . 2003 . Role of viticultural factors on stilbene concentrations of grapes and wine . Drugs Exp. Clin. Res. , 29 ( 5–6 ) : 181 – 187 .
   PubMedGoogle Scholar
• Becker , J. V. W. , Armstrong , G. O. , van der Merwe , M. J. , Lambrechts , M. G. , Vivier , M. A. and Pretorius , I. S. 2003 . Metabolic engineering of Saccharomyces cereviseae for the synthesis of wine-related antioxidant resveratrol . FEMS Yeast Res. , 4 : 79 – 85 .
   PubMed Web of Science ®Google Scholar
• Belguendouz , L. , Fremont , L. and Gozzelino , M. T . 1998 . Interaction of trans-resveratrol with plasma lipoproteins . Biochem. Pharmacol. , 55 : 811 – 816 .
   PubMed Web of Science ®Google Scholar
• Biolley , J. P. , Kanoun , M. , Junqua , M. and Goulas , P. 1998 . Elicitation of phytoalexins in bean leaves (Phaseolus vulgaris L., cv Bergamo) by a moderate chronic ozone stress . 2nd International Electronic Conference on Synthetic Organic Chemistry (ECSOC-2), September 1–30. Basel, Switzerland. http://www.mdpi.org/ecsoc/
   Google Scholar
• Boue , S. M. , Cleveland , T. E. , Carter-Wientjes , C. , Shih , B. Y. , Bhatnagar , D. , McLachlan , J. M. and Burow , M. E. 2009 . Phytoalexin-enriched functional foods . J. Agric. Food Chem. , 57 : 2614 – 2622 .
   PubMed Web of Science ®Google Scholar
• Brandolini , V. , Maietti , A. , Tedeschi , P. , Durini , E. , Vetuani , S. and Manfredini , S. 2002 . Capillary electrophoresis determination, synthesis, and stability of resveratrol and related 3-O-β-D-glucopyronosides . J. Agric. Food Chem. , 50 : 7407 – 7411 .
   PubMed Web of Science ®Google Scholar
• Burns , J. , Yokota , T. , Ashihara , H. , Lean , M. E. J. and Crozier , A. 2002 . Plant foods and herbal sources of resveratrol . J. Agric. Food Chem. , 50 : 3337 – 3340 .
   PubMed Web of Science ®Google Scholar
• Cantos , E. , Espin , J. C. , Fernandez , M. J. , Oliva , J. and Tomas-Barberan , F. A. 2003 . Postharvest UV-C irradiated grapes as a potential source for producing stilbene-enriched red wines . J. Agric. Food Chem. , 51 : 1208 – 1214 .
   PubMed Web of Science ®Google Scholar
• Cantos , E. , Garcia-Viguera , C. , de Pascual-Teresa , S. and Tomas-Barberan , F. A. 2000 . Effect of postharvest ultraviolet irradiation on resveratrol and other phenolics of Cv. Napoleon table grapes . J. Agric. Food Chem. , 48 : 4606 – 4612 .
   PubMed Web of Science ®Google Scholar
• Cantos , E. , Espin , J, C. and Tomas-Barberan , F. A. 2001 . Postharvest induction modeling method using UV irradiation pulses for obtaining resveratrol-enriched table grapes: a new “functional” fruit? . J. Agric. Food Chem. , 49 : 5052 – 5058 .
   PubMed Web of Science ®Google Scholar
• Cantos , E. , Espin , J. C. and Tomas-Barberan , F. A . 2002 . Postharvest stilbene-enrichment of red and white table grape varieties using UV-C irradiation pulses . J. Agric. Food Chem. , 50 : 6322 – 6329 .
   PubMed Web of Science ®Google Scholar
• Castañeda , P. and Perez , L. M. 1996 . Calcium ions promote the response of citrus limon against fungal elicitors or wounding . Phytochemistry , 42 ( 3 ) : 595 – 598 .
   Web of Science ®Google Scholar
• CDC (Centers for Disease Control and Prevention, Department of Health and Human Services) . 2007a . Preventing and controlling cancer: the nation's second leading cause of death at a glance 2007. . Available from http:/www.cdc.gov/nccdphp/publications/aag/dcpc.htm. Accessed September 12, 2007
   Google Scholar
• CDC (Centers for Disease Control and Prevention, Department of Health and Human Services) . 2007b . Division for heart disease and stroke prevention: addressing the nation's leading killer at-a-glance 2007. . Available from http:/www.cdc.gov/nccdphp/publications/AAG/dhdsp.htmAccessed September 12, 2007
   Google Scholar
• Chan , W. H. 2005 . Effect of resveratrol on high glucose-induced stress in human leukemia K562 cells . J. Cell Biochem. , 94 ( 6 ) : 1267 – 1279 .
   PubMed Web of Science ®Google Scholar
• Chang , J. C. , Lai , Y. H. , Djoko , B. , Wu , P. L. , Liu , C. D. , Liu , Y. W. and Chiuo , Y. Y. 2006 . Biosynthesis enhancement and antioxidant and anti-inflammatory activities of peanut (Arachis hypogaea L.) arachidin-1, arachidin-3, and isopentadienylresveratrol . J. Agric. Food Chem. , 54 : 10281 – 10287 .
   PubMed Web of Science ®Google Scholar
• Chen , L. , Han , Y. , Yang , F. and Zhang , T. 2001 . High-speed counter-current chromatography separation and purification of resveratrol and piceid from Polygonum cuspidatum . J. Chromatogr. A. , 907 : 343 – 346 .
   PubMed Web of Science ®Google Scholar
• Chen , R. S. , Wu , P. L. and Chiou , R. Y. Y. 2002 . Peanut roots as a source of resveratrol . J. Agric. Food Chem. , 50 : 1665 – 1667 .
   PubMed Web of Science ®Google Scholar
• Chukwumah , Y. , Walker , L. T. , Verghese , M. and Ogutu , S. 2009 . Effect of frequency and duration of ultrasonication on the extraction efficiency of selected isoflavones and trans-resveratrol from peanuts (Arachis hypogaea) . Ultrasonics Sonochem. , 16 : 293 – 2999 .
   PubMed Web of Science ®Google Scholar
• Chukwumah , Y. , Walker , L. T. , Verghese , M. , Ogutu , S. and Bokanga , M. 2005 . “ Extraction of selected phytochemicals from peanuts (Arachis hypogaea L.) using high-frequency ultrasonication method ” . In Abstract No. 99B-24, Food Chemistry: Effects of Food Processing, Formulation and Component Interactions. 2005 IFT Annual Meeting, July 15–20, 2005 , LA , , USA : New Orleans .
   Google Scholar
• Chung , I. M. , Park , M. R. , Chun , J. C. and Yun , S. J. 2003 . Resveratrol accumulation and resveratrol synthase gene expression in response to abiotic stresses and hormones in peanut plants . Plant Sci. , 164 : 103 – 109 .
   Web of Science ®Google Scholar
• Cooksey , C. J. , Garrrat , P. J. , Richards , S. E. and Strange , R. N. 1988 . A dienyl stilbene phytoalexin from Arachis hypogaea . Phytochemistry , 27 ( 4 ) : 1015 – 1016 .
   Google Scholar
• Creasy , L. L. and Coffee , M. 1988 . Phytoalexin production potential of grape berries . J. Amer. Soc. Hort. Sci. , 113 ( 2 ) : 230 – 234 .
   Web of Science ®Google Scholar
• Daigle , D. J. , Conkerton , E. J. , Sanders , T. H. and Mixon , A. C. 1988 . Peanut hull flavonoids: their relationship with peanut maturity . J. Agric. Food Chem. , 36 : 1179 – 1181 .
   Web of Science ®Google Scholar
• Das , S. , Cordis , G. A. , Maulik , N. and Das , D. K. 2004 . Pharmocological preconditioning with resveratrol: role of CREB-dependent Bcl-2-signalling via adenosine A3 receptor activation . Am. J. Physiol. Heart Circ. Physiol. , 1 : 288 – 294 .
   Google Scholar
• De la Lastra , C. A. and Villegas , I. 2005 . Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications . Mol. Nutr. Food Res , 49 : 405 – 430 .
   PubMed Web of Science ®Google Scholar
• Delmas , D. , Jannin , B. and Latruffe , N. 2005 . Resveratrol: preventing properties against vascular alterations and ageing . Mol. Nutr. Food Res. , 49 ( 5 ) : 377 – 395 .
   PubMed Web of Science ®Google Scholar
• Delmas , D. , Rebe , C , Lacour , S. , Filomenko , R. , Athias , A. , Gambert , P. , Cherkaoui-Malki , M. , Jannin , B. , Dubrez-Daloz , L. , Latruffe , N. and Solary , E. 2003 . Resveratrol-induced apoptosis s associated with FAS redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells . J. Biol. Chem. , 278 : 41482 – 41490 .
   PubMed Web of Science ®Google Scholar
• Dominguez , C. , Guillen , D. A. and Barroso , C. G. 2001 . Automated solid-phase extraction for sample preparation followed by high-performance liquid chromatography with diode array and mass spectrometric detection for the analysis of resveratrol derivatives in wine . Chromatogr. A. , 918 : 303 – 310 .
   PubMed Web of Science ®Google Scholar
• Dörrie , J. , Gerauer , H. , Wachter , Y. and Zunino , S. J. 2001 . Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells . Cancer Res , 61 : 4731 – 4739 .
   PubMed Web of Science ®Google Scholar
• Duh , P. D. and Yen , G. C. 1995 . Changes in antioxidant activity of components of methanolic extracts of peanut hulls irradiated with ultraviolet light . Food Chem. , 54 : 127 – 131 .
   Web of Science ®Google Scholar
• Edwards , C. and Strange , R. N. 1991 . Separation and identification of phytoalexins from leaves of groundnut (Arachis hypogaea) and development of a method for their determination by reverse-phase high-performance liquid chromatography . J. Chromatogr. , 547 : 185 – 193 .
   Web of Science ®Google Scholar
• El-Mowafy , A. and Alkhalaf , M. 2003 . Resveratrol activates adenylyl-cyclase in human breast cancer cells: a novel, estrogen receptor-independent cytostatic mechanism . Carcinogenesis. , 24 ( 5 ) : 869 – 873 .
   PubMed Web of Science ®Google Scholar
• Ferrero , M. E. , Bertelli , A. A. E. , Pellegatta , F. , Fulgenzi , A. , Corsi , M. M. and Bertelli , A. 1998 . Phytoalexin resveratrol (3–4′-5-trihydroxystilbene) modulates granulocyte and monocyte endothelial adhesion . Transplant. Proc. , 30 : 4191 – 4193 .
   PubMed Web of Science ®Google Scholar
• Francisco , M. L. D. L. and Resurreccion , A. V. A. 2009 . Development of a reverse-phase high performance liquid chromatography (RP-HPLC) procedure for the simultaneous determination of phenolic compounds in peanut skin extracts . Food Chem. , 117 : 353 – 363 .
   Web of Science ®Google Scholar
• Frankel , E. N. , Waterhouse , J. E. and Kinsella , J. E. 1993 . Inhibition of human LDL oxidation by resveratrol . Lancet. , 341 : 1103 – 1104 .
   PubMed Web of Science ®Google Scholar
• Gao , L. , Chu , Q. and Ye , J. 2002 . Determination of trans-resveratrol in wines, herbs, and health food by capillary electrophoresis with electrochemical detection . Food Chem , 78 : 255 – 260 .
   Web of Science ®Google Scholar
• Garcia-Garcia , J. , Micol , V. , de Godos , A. and Gomez-Fernandez , J. C. 1999 . The cancer chemopreventive agent resveratrol is incorporated into model membranes and inhibits proteine kinase C α activity . Arch. Biochem. Biophys. , 372 : 382 – 388 .
   PubMed Web of Science ®Google Scholar
• Geahlen , R. L. and McLaughlin , J. L. 1989 . Piceatannol (3,4,3′,5′-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine-kinase inhibitor . Biochem. Biophys. Res. Commun. , 165 : 241 – 245 .
   PubMed Web of Science ®Google Scholar
• Gehm , B. D. , McAndrews , J. M. , Chien , P. Y. and Jameson , J. L. 1997 . Resveratrol, a polyphenolic compound found in grapes and wine is an agonist for the estrogen receptor . Proc. Natl. Acad. Sci. , 94 : 14138 – 14143 .
   PubMed Web of Science ®Google Scholar
• Gerogiannaki-Christopoulou , M. , Athanasopoulos , P. , Kyriakidis , N. , Gerogiannaki , I. A. and Spanos , M. 2006 . trans-Resveratrol in wines from the major Greek red and white grape varieties . Food Control. , 17 : 700 – 706 .
   Web of Science ®Google Scholar
• Giorcelli , A. , Sparvoli , F. , Mattivi , F. , Tava , A. , Balestrazzi , A. , Vrhovsek , U. , Calligari , P. , Bollini , R. and Confalonieri , M. 2004 . Expression of the stilbene synthase (StSy) gene from grapevine in transgenic white poplar results in high accumulation of the antioxidant compounds resveratrol glucosides . Transgenic Res. , 13 : 203 – 214 .
   PubMed Web of Science ®Google Scholar
• Grimmig , B. , Schubert , R. , Fischer , R. , Hain , R. , Schreier , P. H. , Betz , C. , Langebartels , C. , Ernst , D. and Sandermann , H. Jr . 1997 . Ozone- and ethylene-induced regulation of a grapevine resveratrol synthase promoter in transgenic tobacco . Acta Physiologiae Plantarum , 19 : 467 – 474 .
   Web of Science ®Google Scholar
• Grippi , F. , Crosta , L. , Aiello , G. , Tolomeo , M. , Oliveri , F. , Gebbia , N. and Curione , A. 2008 . Determination of stilbenes in Sicilian pistachio by high-performace liquid chromatographic diode array diode array (HPLC-DAD/FLD) and evaluation of eventually mycotoxin contamination . Food Chem , 107 : 483 – 488 .
   Web of Science ®Google Scholar
• Gu , X. , Chu , Q. , O’Dwyer , M. and Zeece , M. 2000 . Analysis of resveratrol in wine by capillary electrophoresis . J. Chromagr. A. , 881 : 471 – 481 .
   PubMed Web of Science ®Google Scholar
• Gupta , Y. K. , Sharma , M. and Brival , S. 2004 . Antinociceptive effect of trans-resveratrol in rats: involvement of an opiodergic mechanism . Methods Find. Exp. Clin. Pharmacol. , 26 ( 9 ) : 667 – 672 .
   PubMed Web of Science ®Google Scholar
• Hain , R. , Bieseler , B. , Kindl , H. , Schroder , G. and Stocker , R. 1990 . Expression of stilbene synthase gene in Nicotiana tabacum results in synthesis of the phytoalexin, resveratrol . Plant Mol. Biol. , 15 ( 2 ) : 325 – 335 .
   PubMed Web of Science ®Google Scholar
• Hanawa , F. , Tahara , S. and Mizutani , J. 1992 . Antifungal stress compounds from Veratrum grandiflorum leaves treated with cupric chloride . Phytochemistry , 31 : 3005 – 3007 .
   Web of Science ®Google Scholar
• Henry , C. , Vitrac , X. , Decendit , A. , Ennamany , R. , Krisa , S. and Merillon , J. M. 2005 . Cellular uptake and efflux of trans-piceid and its aglycon trans-resveratrol on the apical membrane of human intestinal Caco-2 cells . J. Agric. Food Chem. , 53 : 798 – 803 .
   PubMed Web of Science ®Google Scholar
• Henry-Vitrac , C. , Desmouliere , A. , Girard , D. , Merillon , J. M. and Krisa , S. 2006 . Transport, deglycosylation, and metabolism of trans-piceid by small intestinal epithelial cells . Eur. J. Nutr. , 45 : 376 – 382 .
   PubMed Web of Science ®Google Scholar
• Holmes-McNary , M. and Baldwin , A. S. 2000 . Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of IkB kinase . Cancer Res , 60 : 3477 – 3483 .
   PubMed Web of Science ®Google Scholar
• Hsieh , T. C. , Juan , G. , Darzynkiewics , Z. and Wu , J. M. 1999 . Resveratrol increases nitric oxide synthase, induces accumulation of p53 and p21WAF1/CIP1, and suppresses culture bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G21 . Cancer Res. , 59 : 2596 – 2601 .
   PubMed Web of Science ®Google Scholar
• Hsieh , T. C. and Wu , J. M. 2000 . Grape-derived chemopreventive agent resveratrol decreases prostate-specific antigen (PSA) expression in LNCaP cells by androgen receptor (AR)-independent mechanism . Anticancer Res. , 20 : 225 – 228 .
   PubMed Web of Science ®Google Scholar
• Huang , C. , Ma , W. Y. , Goranson , A. and Dong , Z. 1999 . Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway . Carcinogenesis. , 20 : 237 – 242 .
   PubMed Web of Science ®Google Scholar
• Huang , S. C. , Yen , G. C. , Chang , L. W. , Yen , W. J. and Duh , P. D. 2003 . Identification of an antioxidant, ethyl protocatechuate, in peanut seed testa . J. Agric. Food Chem. , 51 : 2380 – 2383 .
   PubMed Web of Science ®Google Scholar
• Ibern-Gomez , M. , Roig-Perez , S. , Lamuela-Raventos , R. M. and de la Torre-Boronat , M. C. 2000 . Resveratrol and piceid levels in natural and blended peanuts . J. Agric. Food Chem. , 48 : 6352 – 6354 .
   PubMed Web of Science ®Google Scholar
• Ingham , J. L. 1976 . 3,5,4′-trihydroxystilbene as a phytoalexin from groundnuts (Arachis hypogaea) . Phytochemistry , 15 : 1791 – 1793 .
   Web of Science ®Google Scholar
• Jang , J. H. and Surh , Y. J. 2003 . Protective effect of resveratrol on β-amyloid-induced oxidative PC12 cell death . Free Radic. Biol. Med. , 34 : 1100 – 1110 .
   PubMed Web of Science ®Google Scholar
• Jang , M. , Cai , L. , Udeani , G. O. , Slowing , K. V. , Thomas , C. F. , Beecher , C. W. W. , Fong , H. S. S. , Farnsworth , N. R. , Kinghorn , A. D. , Mehta , R. G. , Moon , R. C. and Pezzuto , J. M. 1997 . Cancer chemopreventive activity of resveratrol, a natural product derived from grapes . Science , 275 : 218 – 220 .
   PubMed Web of Science ®Google Scholar
• Jeandet , P. , Bessis , R. , Maume , B. F. , Meunier , P. , Peyron , D. and Trollat , P. 1995 . Effect of enological practices on the resveratrol isomer content of wine . J. Agric. Food Chem. , 43 : 316 – 319 .
   Web of Science ®Google Scholar
• Kageura , T. , Matsuda , H. , Morikawa , T. , Toguchida , I. , Harima , S. , Oda , M. and Yoshikawa , M. 2001 . Inhibitors from rhubarb on lipopolysaccharide-induced nitric oxide production on macrophages; structural requirements of stilbenes for the activity . Bioorg. Med. Chem. , 9 : 1887 – 1893 .
   PubMed Web of Science ®Google Scholar
• Kaneuchi , M. , Sasaki , M. , Tanaka , Y. , Yamamoto , R. , Sakuragi , N. and Dahiya , R. 1998 . Resveratrol suppresses growth of Ishikawa cells through down-regulation of EGF . Int. J. Oncol. , 23 : 1167 – 1172 .
   Google Scholar
• Kato , H. , Kodama , O. and Akatsuka , T. 1993 . Oryzalexin E, a diterpene phytoalexin from UV-irradiated rice leaves . Phytochemistry , 33 : 79 – 81 .
   Web of Science ®Google Scholar
• Keen , N. T. 1975 . The isolation of phytoalexins from germinating seeds of Cicer aritinum, Vina sinensis, Arachis hypogaea, and other plants . Phytopathology. , 65 : 91 – 92 .
   Web of Science ®Google Scholar
• Keen , N. T. and Ingham , J. L. 1976 . New stilbene phytoalexins from American cultivars of Arachis hypogaea . Phytochemistry , 16 : 1794 – 1795 .
   Web of Science ®Google Scholar
• Kim , H. I. , Kim , T. H. and Song , J. H. 2005 . Resveratrol inhibits Na+ currents in rat dorsal root ganglion neurons . Brain Res. , 1045 : 134 – 141 .
   PubMed Web of Science ®Google Scholar
• Kimura , Y. , Ohminami , H. , Okuda , H. , Baba , K. , Kozawa , M. and Arichi , S. 1983 . Effects of stilbene components of roots of Polygonum spp. On liver injury in peroxidized oil-fed rats . Planta Med. , 49 : 51 – 54 .
   PubMed Web of Science ®Google Scholar
• Kimura , Y. , Okuda , H. and Kudo , M. 1995 . Effect of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes . J. Ethnopharmacol. , 45 : 131 – 139 .
   PubMed Web of Science ®Google Scholar
• King , R. E. , Bomser , A. B. and Min , D. B. 2006 . Bioactivity of resveratrol . Comprehensive Rev. Food Sci. Food Safety. , 5 : 65 – 70 .
   Web of Science ®Google Scholar
• Kodama , O. , Suzuki , T. and Miyakawa , J. 1988 . Ultraviolet-induced accumulation of phytoalexins in rice leaves . Agric. Biol. Chem. , 52 : 2469 – 2473 .
   Web of Science ®Google Scholar
• Kolouchova-Hanzlikova , I. , Melzoch , K. , Filip , V. and Smidrkal , J. 2004 . Rapid method for resveratrol determination by HPLC with electrochemical and UV detections in wines . Food Chem. , 87 : 151 – 158 .
   Web of Science ®Google Scholar
• Kuhnle , G. , Spencer , J. P. E. , Chowrimootoo , G. , Schroeter , H. , Debnam , E. S. , Srai , S. K. S. , Rice-Evans , C. and Hahn , U. 2000 . Resveratrol is absorbed in the small intestine as resveratrol glucuronide . Biochem. Biophys. Res. Commun. , 272 : 212 – 217 .
   PubMed Web of Science ®Google Scholar
• Ku , K-L. , Chang , P-S. , Cheng , Y-C. and Lien , C-Y. 2005 . Production of stilbenoids from the callus of Arachis hypogaea: a novel source of anticancer compound piceatannol . J. Agric. Food Chem. , 53 : 3877 – 3881 .
   PubMed Web of Science ®Google Scholar
• Laden , B P and Porter , T. D. 2001 . Resveratrol inhibits human squalene monooxygenase . Nutr. Res. , 21 ( 5 ) : 747 – 753 .
   Web of Science ®Google Scholar
• Lamuela-Raventos , R. M. , Romero-Perez , A. I. , Waterhouse , A. L. and dela Torre-Boronat , M. C. 1995 . Direct HPLC analysis of cis and trans-resveratrol and piceid isomers in Spanish red Vitis vinefera wines . J. Agric. Food Chem. , 43 : 281 – 283 .
   Web of Science ®Google Scholar
• Langcake , P. and Pryce , R. J. 1976 . The production of resveratrol by Vitis vinifera and other members of the Vitacee as a response to infection or injury . Physiol. Plant Path , 9 : 77 – 86 .
   Google Scholar
• Langcake , P. and Pryce , R. J. 1977 . The production of resveratrol and the viniferins by grapevines in response to ultraviolet irradiation . Phytochemistry. , 16 : 1193 – 1196 .
   Web of Science ®Google Scholar
• Lee , S. S , Lee , S. M. , Kim , M. , Chun , J. , Cheong , Y. K. and Lee , J. 2004 . Analysis of trans-resveratrol in peanuts and peanut butters consumed in Korea . Food Res. Int. , 37 : 247 – 251 .
   Web of Science ®Google Scholar
• Lin , L. L. , Lien , C. Y. , Cheng , Y. C. and Ku , K. L. 2007 . An effective sample preparation for screening the anticancer compound piceatannol using HPLC coupled with UV and fluorescence detection . J. Chromatogr. B. , 853 : 175 – 182 .
   PubMed Web of Science ®Google Scholar
• Lin , L. , Wu , J. , Ho , K. P. and Qi , S. 2001 . Ultrasound-induced physiological effects and secondary metabolite (saponin) production in Panax ginseng cell cultures . Ultrasound Med. Biol. , 27 ( 8 ) : 1147 – 1152 .
   PubMed Web of Science ®Google Scholar
• Lu , R. and Serrero , G. 1999 . Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells . J. Cellular Physiol. , 179 : 297 – 304 .
   PubMed Web of Science ®Google Scholar
• Luan , T. , Li , G. and Zhang , Z. 2000 . Gas-phase postderivatization following solid-phase microextraction for rapid determination of trans-resveratrol in wine by gas chromatography-mass spectrometry . Anal. Chim. Acta , 424 : 19 – 25 .
   Web of Science ®Google Scholar
• Lyons , M. M. , Yu , C. and Toma , R. B. 2003 . Resveratrol in raw and baked blueberries and bilberries . J. Agric. Food Chem. , 51 : 5867 – 5870 .
   PubMed Web of Science ®Google Scholar
• Malovana , S. , Garcia-Montealegro , F. J. , Perez , J. P. and Rodriguez-Delgado , M. A. 2001 . Optimization of sample preparation for the determination of trans-resveratrol and other polyphenolic compounds in wines by high performance liquid chromatography . Anal. Chim. Acta. , 428 : 245 – 253 .
   Web of Science ®Google Scholar
• Marambaud , P , Zhao , H and Davies , P. 2005 . Resveratrol promotes clearance of Alzheimer's disease amyloid-β peptides . J. Biol. Chem. Mol. Biol. , 280 ( 45 ) : 37377 – 37382 .
   PubMed Web of Science ®Google Scholar
• Marier , J. F. , Vachon , P. , Gritsas , A. , Zhang , J. , Moreau , J. P. and Ducharme , M. P. 2002 . Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model . J. Pharmacol. Experimental Therapeutics. , 302 : 369 – 373 .
   PubMed Web of Science ®Google Scholar
• Matsuoka , A. , Takeshita , K. , Furuta , A. , Ozaki , M. , Fukuhara , K. and Miyata , N. 2002 . The 4′-hydroxy group is responsible for the in vitro cytogenetic activity of resveratrol . Mutat. Res. , 521 ( 1–2 ) : 29 – 35 .
   PubMed Web of Science ®Google Scholar
• Medina-Bolivar , F. , Condori , J. , Rimando , A. M. , Hubstenberger , J. , Shelton , K. , O’Keefe , S. F. , Bennett , S. and Dolan , M. C. 2007 . Production and secretion of resveratrol in hairy root cultures of peanut . Phytochemistry. , 68 : 1992 – 2003 .
   PubMed Web of Science ®Google Scholar
• Mitchell , S. H. , Zhu , W. and Young , C. Y. 1999 . Resveratrol inhibits the expression and function of the androgen in LBCaP prostate cancer cells . Cancer Res. , 59 : 5892 – 5895 .
   PubMed Web of Science ®Google Scholar
• Moreno-Labanda , J. F. , Mallavia , R. , Perez-Fons , L. , Lizama , V. , Saura , D. and Micol , V. 2004 . Determination of piceid and resveratrol in Spanish wines deriving from Monastrell (Vitis vinifera L.) grape variety . J. Agric. Food Chem. , 52 : 5396 – 5403 .
   PubMed Web of Science ®Google Scholar
• Nepote , V. , Grosso , N. R. and Guzman , C. A. 2004 . Radical scavenging activity of extracts of Argentine peanut skins (Arachis hypogaea) in relation to its trans-resveratrol content . J. Argentine Chem. Soc. , 92 ( 4/6 ) : 41 – 49 .
   Google Scholar
• Nicolini , G. , Rigolio , R. , Miloso , M. , Bertelli , A. A. and Tredici , G. 2001 . Antiapoptosis effect of trans-resveratrol on paclitaxel-induced apoptosin in human neuroblastoma SH-SYY cell line . Neurosci. Lett. , 302 : 41 – 44 .
   PubMed Web of Science ®Google Scholar
• Pace-Asciak , C. R. , Hahn , S. , Diamandis , E. P. , Soleas , G. and Goldberg , D. M. 1995 . The red wine phenolics trans/resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart6 disease . Clin. Chimica Acta. , 235 : 207 – 219 .
   PubMed Web of Science ®Google Scholar
• Palmieri , L. , Mamelia , M. and Ronca , G. 1999 . Effect of resveratrol and some other natural compounds on tyrosine kinase activity and on cytolysis . Drugs Exp. Clin. Res. , 25 ( 2–3 ) : 79 – 85 .
   PubMedGoogle Scholar
• Pearce , G. , Merchand , P. A. , Griswold , J. , Lewis , N. G. and Ryan , C. A. 1998 . Accumulation of feruloyltyramine and ρ-coumaroyltyramin in tomato leaves in response to wounding . Phytochemistry , 47 ( 4 ) : 659 – 664 .
   Web of Science ®Google Scholar
• Peña-Farfal , C. , Moreda-Piñiero , A. , Bermejo-Barrera , A. , Bermejo-Barrrera , P. , Pinochet-Cancino , H. and de Gregori-Henriquez , I. 2005 . Speeding up enzymatic hydrolysis procedures for multi-element determination in edible seaweed . Analytica Chimica Acta. , 548 ( 1–2 ) : 183 – 191 .
   Web of Science ®Google Scholar
• Pennington , J. A. T. 2002 . Food composition databases for bioactive food components . J. Food Comp. Anal. , 15 : 419 – 434 .
   Web of Science ®Google Scholar
• Potter , G. A. , Patterson , L. H. , Wanogho , E. , Perry , P. J. , Butler , P. C. , Ijaz , T. , Ruparelia , K. C , Lamb , J. H. , Farmer , P. B. , Stanley , L. A. and Burke , M. D. 2002 . The cancer preventative agent resveratrol is converted to the anticancer agent piceatonnol by the cytochrome P450 enzyme CYP1B1 . British J. Cancer. , 86 : 774 – 778 .
   PubMed Web of Science ®Google Scholar
• Potrebko , I. and Resurreccion , A. V. A. 2009 . Effect of ultraviolet doses in combined ultraviolet-ultrasound treatment on trans-resveratrol and trans-piceid contents in sliced peanut kernels . J. Agric. Food Chem. , 57 : 7750 – 7756 .
   PubMed Web of Science ®Google Scholar
• Putnam , D. H. , Oplinger , E. S. , Teynor , T. M. , Oelke , E. A. , Kelling , K. A. and Doll , J. D. 2000 . “ Peanut ” . In Alternative Field Crops Manual , University of Wisconsin Cooperative Extension, University of Minnesota Center for Alternative Plant and Animal Products, and the Minnesota Extension Service. St. Paul, Minnesota .
   Google Scholar
• Regev-Shoshani , G. , Shoseyov , O. , Bilkis , I. and Kerem , Z. 2003 . Glycosylation of resveratrol protects it from enzymic oxidation . Biochem. J. , 374 : 157 – 163 .
   PubMed Web of Science ®Google Scholar
• Regione , F. D. , Cucciolla , V. , Criniti , V. , Indaco , S. , Borriello , A. and Zappia , V. 2003 . P21CiP1 gene expression is modulated by Egr1: a novel regulatory mechanism involved in the resveratrol antiproliferative effect . J. Biol. Chem. , 278 : 23360 – 23368 .
   PubMed Web of Science ®Google Scholar
• Reviere , C. , Richard , T. , Quentin , L. , Krisa , S. , Merillon , J-M. and Monti , J-P. 2007 . Inhibitory activity of stilbenes on Alzheimer's β-amyloid fibrils in vitro . Bioorg. Med. Chem. , 15 : 1160 – 1167 .
   PubMed Web of Science ®Google Scholar
• Romero-Perez , A. I. , Lamuela-Raventos , R. M. , Andres-Lacueva , C. and De la Torre-Boronat , M. C. 2001 . Method for quantitative extraction of resveratrol and piceid isomers in grape berry skins. Effect of powdery mildew on the stilbene content . J. Agric. Food Chem. , 49 : 210 – 215 .
   PubMed Web of Science ®Google Scholar
• Rudolf , J. L. 2003 . Development of an HPLC Method for Resveratrol and Optimization of Post-Harvest Stress to Induce Production in Peanuts. Master's thesis , Athens , GA : University of Georgia .
   Google Scholar
• Rudolf , J. L. , Phillips , R. D. , Chinnan , M. S. and Resurreccion , A. V. A. 2002 . Postharvest induction of resveratrol in peanut kernels by grinding . Abstract No. 15C–9. IFT Annual Meeting, June 13–16, 2002, Anaheim, CA
   Google Scholar
• Rudolf , J. L. and Resurreccion , A. V. A. 2005 . Elicitation of resveratrol in peanut kernels by application of abiotic stresses . J. Agric. Food Chem. , 53 : 10186 – 10192 .
   PubMed Web of Science ®Google Scholar
• Rudolf , J. L. and Resurreccion , A. V. A. 2007 . Optimization of trans-resveratrol concentration and sensory properties of peanut kernels, by slicing and ultrasound treatment, using response surface methodology . J. Food Sci. , 72 ( 7 ) : S450 – S462 .
   Google Scholar
• Rudolf , J. L. , Resurreccion , A. V. A. , Saalia , F. K. and Phillips , R. D. 2005 . Development of reverse-phase high performance liquid chromatography method for analyzing trans-resveratrol in peanut kernels . Food Chem. , 89 : 623 – 638 .
   Web of Science ®Google Scholar
• Sales , J. M. and Resurreccion , A. V. A. 2009 . Maximising resveratrol and piceid contents in UV and ultrasound treated peanuts . Food Chem. , 117 : 674 – 680 .
   Web of Science ®Google Scholar
• Samuel , M. A. , Miles , G. P. and Ellis , B. E. 2000 . Ozone treatment rapidly activates MAP kinase signaling in plants . Plant J. , 4 : 367 – 376 .
   Web of Science ®Google Scholar
• Sanders , T. H. and McMichael , R. W. Jr . 1997 . “ Occurrence of resveratrol in edible peanuts ” . In Book of Abstracts, Abstr. AGFD 214:33 , Las Vegas , NV : American Chemical Society: Washington, DC .
   Google Scholar
• Sanders , T. H. , McMichael , R. W. Jr and Hendrix , K. W. 2000 . Occurrence of resveratrol in edible peanuts . J. Agric. Food Chem. , 48 : 1243 – 1246 .
   PubMed Web of Science ®Google Scholar
• Sarig , P. , Zahavi , T. , Zutkhi , Y. , Yannai , S. , Lisker , N. and Ben-Arie , R. 1996 . Ozone for control of post-harvest decay of table grapes caused by Rhizopus stolonifer . Physiol. Mol. Plant Path , 48 : 403 – 415 .
   Web of Science ®Google Scholar
• Scarletti , F. , Sala , G. , Somenzi , G. , Signorelli , P. , Sacchi , N. and Ghidoni , R. 2003 . Resveratrol induces growth, inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling . FASEB J. , 17 : 2339 – 2341 .
   PubMed Web of Science ®Google Scholar
• Seo , J. E. , Lee , E. E. , Chun , J. , Lee , H. B. and Lee , J. 2005 . “ Optimization for the post-harvest induction of trans-resveratrol in raw peanuts ” . In Abstract on Session 99B, Food Chemistry: Effects of food processing, formulation and component interactions, presented at 2005 IFT Annual Meeting New Orleans , LA July 15–20
   Google Scholar
• She , Q. B. , Bode , A. M. , Ma , W. Y. , Chen , N. Y. and Dong , Z. 2001 . Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase . Cancer Res. , 61 : 1604 – 1610 .
   PubMed Web of Science ®Google Scholar
• Shen , F. , Chen , S. J. , Dong , X. J. , Zhong , H. , Li , Y. T. and Cheng , G. F. 2003 . Suppression of IL-8 gene transcription by resveratrol on phorbol ester treated human monocytic cells . J. Asian Nat. Prod. Res. , 5 : 151 – 157 .
   PubMed Web of Science ®Google Scholar
• Sobolev , V. S. and Cole , R. J. 1999 . trans-Resveratrol content in commercial peanuts and peanut products . J. Agric. Food Chem. , 47 : 1435 – 1439 .
   PubMed Web of Science ®Google Scholar
• Sobolev , V. S. , Cole , R. J. and Dorner , J. W. 1995 . Isolation, purification, and liquid chromatographic determination of stilbene phytoalexins in peanuts . JAOAC Int , 78 ( 5 ) : 1177 – 1182 .
   Google Scholar
• Sobolev , V. S. , Neff , S. A. and Gloer , J. B. 2009 . New stilbenoids from peanut (Arachis hypogaea) seeds challenged by an Aspergillus flavus strain . J. Agric. Food Chem. , 57 : 62 – 68 .
   PubMed Web of Science ®Google Scholar
• Soleas , G. J. , Diamandis , E. P. and Goldberg , DM. 1997 . Resveratrol, a molecule whose time has come? and gone? . Clinical Biochem , 30 ( 2 ) : 1 – 113 .
   PubMed Web of Science ®Google Scholar
• Stanley , L. L. and Mazier , P. 1999 . Potential explanations for the paradox . Nutr. Res. , 19 ( 1 ) : 3 – 15 .
   Web of Science ®Google Scholar
• Stewart , J. R. , Ward , N. E. , Ionnides , C. G. and O’Brian , C. A. 1999 . Resveratrol preferentially inhibits protein kinase C-catalyzed phosphorylation of a co-factor-independent, arginine-rich protein substrate by a novel mechanism . Biochem. , 38 : 13224 – 13251 .
   Google Scholar
• Subba Rao , P. V. , Wadia , K. D. R. and Strange , R. N. 1996 . Biotic and abiotic elicitation of phytoalexins in leaves of groundnut (Arachis hypogaea L.) . Physiol. Mol. Plant Path. , 49 : 343 – 357 .
   Web of Science ®Google Scholar
• Sun , A. Y. , Chen , Y. , James-Kracke , M. , Wixom , P. and Cheng , Y. 1997 . Ethanol-induced cell death by lipid peroxidation in PC12 cells . Neurochem. Res. , 22 ( 10 ) : 1187 – 1192 .
   PubMed Web of Science ®Google Scholar
• Szende , B. , Tyihak , E. and Kiraly-Veghely , Z. 2000 . Dose-dependent effect of resveratrol on proliferation and apoptosis in endothelial and tumor cell cultures . Exp. Mol. Med. , 32 : 88 – 92 .
   PubMed Web of Science ®Google Scholar
• Talcott , S. T. , Passeretti , S. , Duncan , C. E. and Gorbet , D. W. 2005 . Polyphenolic content and sensory properties of normal and high oleic acid peanuts . Food Chem. , 90 : 379 – 388 .
   Web of Science ®Google Scholar
• Thomzik , J. E. , Stnzel , K. , Stocker , R. , Schreier , P. H. , Hain , R. and Stahl , D. J. 1997 . Synthesis of a grapevine phytoalexin in transgenic tomatoes (Lycopersicon esculentum Mill.) conditions resistance against Phytophthora infestans . Physiol. Mol. Plant. Path. , 51 : 265 – 278 .
   Web of Science ®Google Scholar
• Tokusoglu , O. , Unal , M. K. and Yemis , F. 2005 . Determination of the phytoalexin resveratrol (3, 5, 4′-trihydroxystilbene) in peanuts and pistachios by high-performance liquid chromatographic diode array (HPLC-DAD) and gas chromatography-mass spectrometry (GC-MS) . J. Agric. Food Chem. , 53 ( 12 ) : 5003 – 5009 .
   PubMed Web of Science ®Google Scholar
• Trela , B. C. and Waterhouse , A. L. 1996 . Resveratrol: isomeric molar absorptivities and stability . J. Agric. Food Chem. , 44 ( 5 ) : 1253 – 1257 .
   Web of Science ®Google Scholar
• USDA (United States Department of Agriculture) . 2008a . Economic Research Service. Food availability (per capita) data system . Available from http://www.ers.usda.gov/Data/Foodconsumption Accessed October 2, 2008
   Google Scholar
• USDA (United States Department of Agriculture) . 2008b . National Agricultural Statistics Service. Peanut stocks and processing . Released September 29, 2008. Accessed 08 June 2013 from http://usda01.library.cornell.edu/usda/nass/PeanStocPr//2000s/2008/PeanStocPr-09-29-2008.txt
   Google Scholar
• Vastano , B. C. , Chen , Y. , Zhu , N. , Ho , C. T. , Zhou , Z. and Rosen , R. T. 2000 . Isolation and identification of stilbenes in two varieties of Polygonum cuspidatum . J. Agric. Food Chem. , 48 : 253 – 256 .
   PubMed Web of Science ®Google Scholar
• Wallerath , T. , Deckert , G. , Ternes , T. , Anderson , H. , Li , H. , Witt , K. and Forstermann , U. 2002 . Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase . Circulation. , 106 : 1652 – 1658 .
   PubMed Web of Science ®Google Scholar
• Wang , K. H. , Lai , Y. H. , Chang , J. C. , Ko , T. F. , Shyu , S. L. and Chiou , R. Y. Y. 2005 . Germination of peanut kernels to enhance resveratrol biosynthesis and prepare sprouts as a functional vegetable . J. Agric. Food Chem. , 53 : 242 – 246 .
   PubMed Web of Science ®Google Scholar
• Wang , M. J. , Huang , H. M. , Hsieh , S. J. , Jeng , K. C. G. and Kuo , J. S. 2001 . Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycema followed by re-oxygeneration . J. Neuroimmunol. , 112 : 28 – 34 .
   PubMed Web of Science ®Google Scholar
• Wang , Y. , Catana , F. , Yang , Y. , Roderick , R. and van Breemen , R. B. 2002 . An LC-MS method for analyzing total resveratrol in grape juice, cranberry juice, and in wine . J. Agric. Food Chem. , 50 : 431 – 435 .
   PubMed Web of Science ®Google Scholar
• Waterhouse , A. L. and Lamuela-Raventos , R. M. 1994 . The occurrence of piceid, a stilbene glucoside in grape berries . Phytochemistry , 37 : 571 – 573 .
   Web of Science ®Google Scholar
• Wenzel , E. and Somoza , V. 2005 . Metabolism and bioavailability of trans-resveratrol . Mol. Nutr. Food Res , 49 ( 5 ) : 472 – 481 .
   PubMed Web of Science ®Google Scholar
• Wolter , F. and Stein , J. 2002 . Resveratrol enhances the differentiation induces by butyrate in Caco-2 colon cancer cells . J. Nutr. Cancer. , 132 : 3082 – 3086 .
   Google Scholar
• Wotton , H. R. and Strange , R. N. 1985 . Circumstantial evidence for phytoalexin involvement in the resistance of peanuts for Aspergillus flavus . J. Gen. Microbiol , 131 ( 3 ) : 487 – 494 .
   PubMedGoogle Scholar
• Wu , J. and Lin , L . 2002 . Elicitor-like effects of low-energy ultrasound on plant (Panax ginseng) cells: induction of plant defense responses and secondary metabolite production . Appl. Microbiol. Biotechnol. , 59 : 51 – 57 .
   PubMed Web of Science ®Google Scholar
• Wu , J. , Lin , L. and Chau , F. 2001 . Ultrasound extraction of ginseng saponins from ginseng roots and cultured ginseng cells . Ultrason. Sonochem. , 8 : 347 – 352 .
   PubMed Web of Science ®Google Scholar
• Xiao , Y. , Wu , Q. , Cai , Y. and Lin , X-F. 2005 . Ultrasound-accelerated enzymatic synthesis of sugar esters in non-aqueous solvents . Carbohydr. Res. , 340 : 2097 – 2103 .
   PubMed Web of Science ®Google Scholar
• Yu , J. , Ahmedna , M. and Goktepe , I. 2005 . Effects of processing methods and extraction solvents on concentration and antioxidant activity of peanut skin phenolics . Food Chem. , 90 ( 1–2 ) : 199 – 206 .
   Web of Science ®Google Scholar
• Yu , L. , Sun , Z. J. , Wu , S. L. and Pan , C. E. 2003 . Effect of resveratrol on cell cycle proteins in murine transplant liver cancer . World J. Gastroenterol. , 9 : 2341 – 2343 .
   PubMed Web of Science ®Google Scholar
• Yu , R. , Hebbar , V. , Kim , D. W. , Mandlekar , S. , Pezzuto , J. M. and Kong , A-H. G. T. 2001 . Resveratrol inhibits phorbol ester and uv-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways . Mol. Pharmacol. , 60 : 216 – 224 .
   Google Scholar
• Zheng , W. and Ramirez , V. D. 1999 . Piceatannol, a stilbene phytochemical inhibits mitochondrial F0F1-ATPase activity by targeting F1 complex . Biochem. Biophys. Res. Commun. , 261 : 499 – 503 .
   PubMed Web of Science ®Google Scholar
• Zheng , W. and Wang , S. Y. 2001 . Antioxidant activity and phenolic compounds in selected herbs . J. Agric. Food Chem. , 49 : 5165 – 5170 .
   PubMed Web of Science ®Google Scholar
• Zhu , Y. , Chaing , H. , Zhou , J. and Kissinger , P. T. 2003 . In vitro metabolism study of resveratrol and identification and determination of its metabolite piceatannol by LC/EC and LC/MSMS . Current Separations. , 20 ( 3 ) : 93 – 96 .
   Google Scholar