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Original Articles

Nutraceuticals and Functional Foods in the Management of Hyperlipidemia

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REFERENCES

  • Abe , I. , Seki , T. , Umehara , K. , Miyase , T. , Noguchi , H. , Sakakibara , J. and Ono , T. 2000 . Green tea polyphenols: Novel and potent inhibitors of squalene epoxidase . Biochem. Biophys. Res. Commun. , 268 ( 3 ) : 767 – 771 .
  • Alvaro , A. , Sola , R. , Rosales , R. , Ribalta , J. , Anguera , A. , Masana , L. and Caries Vallve , J. 2008 . Gene expression analysis of a human enterocyte cell line reveals downregulation of cholesterol biosynthesis in response to short-chain fatty acids . Iubmb Life , 60 ( 11 ) : 757 – 764 .
  • Anderson , J. W. , Baird , P. , Davis , R. H. , Ferreri , S. , Knudtson , M. , Koraym , A. , Waters , V. and Williams , C. L. 2009 . Health benefits of dietary fiber . Nutr. Rev. , 67 ( 4 ) : 188 – 205 .
  • Annaba , F. , Kumar , P. , Dudeja , A. K. , Saksena , S. , Gill , R. K. and Alrefai , W. A. 2010 . Green tea catechin EGCG inhibits ileal apical sodium bile acid transporter ASBT . Am. J. Physiol.-Gastrointest. Liver Physiol. , 298 ( 3 ) : G467 – G473 .
  • Attie , A. D. 2007 . ABCA1: At the nexus of cholesterol, HDL and atherosclerosis . Trends Biochem. Sci. , 32 ( 4 ) : 172 – 179 .
  • Auger , C. , Caporiccio , B. , Landrault , N. , Teissedre , P. L , Laurent , C. , Cros , G. , Besancon , P. and Rouanet , J M . 2002 . Red wine phenolic compounds reduce plasma lipids and apolipoprotein B and prevent early aortic atherosclerosis in hypercholesterolemic golden Syrian hamsters (Mesocricetus auratus) . J. Nutr. , 132 ( 6 ) : 1207 – 1213 .
  • Banerjee , S. , Ghoshal , S. and Porter , T. D. 2011 . Activation of AMP-kinase by policosanol requires peroxisomal metabolism . Lipids , 46 ( 4 ) : 311 – 321 .
  • Bartel , D. P. 2009 . MicroRNAs: target recognition and regulatory functions . Cell , 136 ( 2 ) : 215 – 233 .
  • Beaven , S. W. and Tontonoz , P. 2006 . Nuclear receptors in lipid metabolism: Targeting the heart of dyslipidemia . Annu. Rev. Med. , 57 : 313 – 329 .
  • Bensinger , S. J. and Tontonoz , P. 2008 . Integration of metabolism and inflammation by lipid-activated nuclear receptors . Nature , 454 ( 7203 ) : 470 – 477 .
  • Berrougui , H. , Grenier , G. , Loued , S. , Drouin , G. and Khalil , A. 2009 . A new insight into resveratrol as an atheroprotective compound: Inhibition of lipid peroxidation and enhancement of cholesterol efflux . Atherosclerosis , 207 ( 2 ) : 420 – 427 .
  • Bogsrud , M. P. , Ose , L. , Langslet , G. , Ottestad , I. , Strom , E. C. , Hagve , T. A. and Retterstol , K. 2010 . HypoCol (red yeast rice) lowers plasma cholesterol - a randomized placebo controlled study . Scand. Cardiovasc. J. , 44 ( 4 ) : 197 – 200 .
  • Bommer , G. T. and MacDougald , O. A. 2011 . Regulation of lipid homeostasis by the bifunctional SREBF2-miR33a locus . Cell Metab. , 13 ( 3 ) : 241 – 247 .
  • Borochov-Neori , H. , Judeinstein , S. , Greenberg , A. , Fuhrman , B. , Attias , J. , Volkova , N. , Hayek , T. and Aviram , M. 2008 . Phenolic antioxidants and antiatherogenic effects of marula (Sclerocarrya birrea Subsp caffra) fruit juice in healthy humans . J. Agric. Food Chem. , 56 ( 21 ) : 9884 – 9891 .
  • Brown , M. S. and Goldstein , J. L. 1997 . The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor . Cell , 89 ( 3 ) : 331 – 340 .
  • Brown , M. S. and Goldstein , J. L. 1999 . A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood . Proc. Nat. Acad. Sci. USA. , 96 ( 20 ) : 11041 – 11048 .
  • Brown , M. S. and Goldstein , J. L. 2009 . Cholesterol feedback: From Schoenheimer's bottle to Scap's MELADL . J. Lipid Res. , 50 : S15 – S27 .
  • Browning , J. D. and Horton , J. D. 2004 . Molecular mediators of hepatic steatosis and liver injury . J. Clin. Investig. , 114 ( 2 ) : 147 – 152 .
  • Bursill , C. A. and Roach , P. D. 2007 . A green tea catechin extract upregulates the hepatic low-density lipoprotein receptor in rats . Lipids , 42 ( 7 ) : 621 – 627 .
  • Calpe-Berdiel , L. , Escola-Gil , J. C. and Blanco-Vaca , F. 2009 . New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism . Atherosclerosis , 203 ( 1 ) : 18 – 31 .
  • Cao , G. W. , Zhang , H. W. , Zhang , Y. H. , Lu , M. J. and Tong , W. J. 2007 . Comparison of hypertension, dyslipidaemia and hyperglycaemia between buckwheat seed-consuming and non-consuming Mongolian-Chinese populations in inner Mongolia, China . Clin. Exp. Pharmacol. Physiol. , 34 ( 9 ) : 838 – 844 .
  • Castiglioni , S. , Manzoni , C. , Dani , V. , Duranti , M. , Morazzoni , P. and Lovati , M. R. 2004 . Alpha prime subunit from 7S soy globulin upregulates beta-VLDL liver receptors in rats fed a cholesterol-rich diet . J. Nutr. , 134 ( 5 ) : 1276s – 1276s .
  • Charlton-Menys , V. and Durrington , P. N. 2008 . Human cholesterol metabolism and therapeutic molecules . Exp. Physiol. , 93 ( 1 ) : 27 – 42 .
  • Chawla , A. , Repa , J. J. , Evans , R. M. and Mangelsdorf , D. J. 2001 . Nuclear receptors and lipid physiology: Opening the X-files . Sci. , 294 ( 5548 ) : 1866 – 1870 .
  • Chawla , R. and Patil , G. R. 2010 . Soluble dietary fiber . Compr. Rev. Food Sci. Food Saf. , 9 ( 2 ) : 178 – 196 .
  • Chen , G. and Zhang , X. 2010 . New insights into S2P signaling cascades: Regulation, variation, and conservation . Protein Sci. , 19 ( 11 ) : 2015 – 2030 .
  • Chen , J. D. , Wu , Y. Z. , Tao , Z. L. , Chen , Z. M. and Liu , X. P. 1995 . Hawthorn (shan zha) drink and its lowering effect on blood lipid levels in humans and rats . World Rev. Nutr. Diet. , 77 : 147 – 154 .
  • Chen , J. N. , Jiang , Y. , Ma , K. Y. , Chen , F. and Chen , Z. Y. 2011 . Microalga decreases plasma cholesterol by down-regulation of intestinal NPC1L1, hepatic LDL receptor, and HMG-CoA reductase . J. Agric. Food Chem. , 59 ( 12 ) : 6790 – 6797 .
  • Chen , Z. Y. , Jiao , R. and Ma , K. Y. 2008 . Cholesterol-lowering nutraceuticals and functional foods . J. Agric. Food Chem. , 56 ( 19 ) : 8761 – 8773 .
  • Cherif , A. O. , Ben Messaouda , M. , Kaabi , B. , Boukhchina , S. , Pepe , C. and Kallel , H. 2010 . Comparison of the concentrations of long-chain alcohols (Policosanol) in three Tunisian peanut varieties (Arachis hypogaea L.) . J. Agric. Food Chem. , 58 ( 23 ) : 12143 – 12148 .
  • Chiang , J. Y. L. 2009 . Bile acids: Regulation of synthesis . J. Lipid Res. , 50 ( 10 ) : 1955 – 1966 .
  • Chijimatsu , T. , Umeki , M. , Okuda , Y. , Yamada , K. , Oda , H. and Mochizuki , S. 2011 . The fat and protein fractions of freshwater clam (Corbicula fluminea) extract reduce serum cholesterol and enhance bile acid biosynthesis and sterol excretion in hypercholesterolaemic rats fed a high-cholesterol diet . Br. J. Nutr. , 105 ( 4 ) : 526 – 534 .
  • Cho , K. W. , Kim , Y. O. , Andrade , J. E. , Burgess , J. R. and Kim , Y. C. 2011 . Dietary naringenin increases hepatic peroxisome proliferators-activated receptor alpha protein expression and decreases plasma triglyceride and adiposity in rats . Eur. J. Nutr. , 50 ( 2 ) : 81 – 88 .
  • Chung , M. J. , Sung , N. J. , Park , C. S. , Kweon , D. K. , Mantovani , A. , Moon , T. W. , Lee , S. J. and Park , K. H. 2008 . Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57BL/6J mice . Eur. J. Pharmacol. , 578 : 2 – 3 . 159 – 170 .
  • Chung , S. H. , Quan , H. Y. , Yuan , H. D. , Kim , D. Y. and Zhang , Y. 2010 . Korean red ginseng attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cells . Food Sci. Biotechnol. , 19 ( 1 ) : 207 – 212 .
  • Consonni , A. , Lovati , M. R. , Manzoni , C. , Pizzagalli , A. , Morazzoni , P. and Duranti , M. 2010 . Cloning, yeast expression, purification and biological activity of a truncated form of the soybean 7S globulin alpha ‘subunit involved in Hep G2 cell cholesterol homeostasis . J. Nutr. Biochem. , 21 ( 9 ) : 887 – 891 .
  • Crespy , V. and Williamson , G. 2004 . A review of the health effects of green tea catechins in in vivo animal models . J. Nutr. , 134 ( 12 ) : 3431s – 3440s .
  • Cuccioloni , M. , Mozzicafreddo , M. , Spina , M. , Tran , C. N. , Falconi , M. , Eleuteri , A. M. and Angeletti , M. 2011 . Epigallocatechin-3-gallate potently inhibits the in vitro activity of hydroxy-3-methyl-glutaryl-CoA reductase . J. Lipid Res. , 52 ( 5 ) : 897 – 907 .
  • de Mejia , E. G. , Martinez-Villaluenga , C. , Roman , M. and Bringe , N. A. 2010 . Fatty acid synthase and in vitro adipogenic response of human adipocytes inhibited by alpha and alpha ‘ subunits of soybean beta-conglycinin hydrolysates . Food Chem. , 119 ( 4 ) : 1571 – 1577 .
  • Di Castelnuovo , A. , Rotondo , S. , Iacoviello , L. , Donati , M. B. and de Gaetano , G. 2002 . Meta-analysis of wine and beer consumption in relation to vascular risk . Circulation , 105 ( 24 ) : 2836 – 2844 .
  • Dong , J. Y. and Qin , L. Q. 2011 . Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies . Breast Cancer Res. Treat. , 125 ( 2 ) : 315 – 323 .
  • Dulin , M. F. , Hatcher , L. F. , Sasser , H. C. and Barringer , T. A. 2006 . Policosanol is ineffective in the treatment of hypercholesterolemia: A randomized controlled trial . Am. J. Clin. Nutr. , 84 ( 6 ) : 1543 – 1548 .
  • Edwards , P. A. , Kast , H. R. and Anisfeld , A. M. 2002 . BAREing it all: The adoption of LXR and FXR and their roles in lipid homeostasis . J. Lipid Res. , 43 ( 1 ) : 2 – 12 .
  • Fabjan , N. , Rode , J. , Kosir , I. J. , Wang , Z. H. , Zhang , Z. and Kreft , I. 2003 . Tartary buckwheat (Fagopyrum tataricum Gaertn.) as a source of dietary rutin and quercitrin . J. Agric. Food Chem. , 51 ( 22 ) : 6452 – 6455 .
  • Feng , L. J. , Yu , C. H. , Ying , K. J. , Hua , J. A. and Dai , X. Y. 2011 . Hypolipidemic and antioxidant effects of total flavonoids of Perilla Frutescens leaves in hyperlipidemia rats induced by high-fat diet . Food Res. Int. , 44 ( 1 ) : 404 – 409 .
  • Ferre , P. and Foufelle , F. 2010 . Hepatic steatosis: A role for de novo lipogenesis and the transcription factor SREBP-1c . Diabetes Obes. Metab. , 12 : 83 – 92 .
  • Ferreira , E. D. , Silva , M. A. , Demonte , A. and Neves , V. A. 2011 . Soy beta-conglycinin (7S Globulin) reduces plasma and liver cholesterol in rats fed hypercholesterolemic diet . J. Med. Food , 14 ( 1–2 ) : 94 – 100 .
  • Fki , I. , Sahnoun , Z. and Sayadi , S. 2007 . Hypocholesterolemic effects of phenolic extracts and purified hydroxytyrosol recovered from olive mill wastewater in rats fed a cholesterol-rich diet . J. Agric. Food Chem. , 55 ( 3 ) : 624 – 631 .
  • Forman , B. M. , Chen , J. and Evans , R. M. 1997 . Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta . Proc. Nat. Acad. Sci. USA. , 94 ( 9 ) : 4312 – 4317 .
  • Francini-Pesenti , F. , Brocadello , F. , Beltramolli , D. , Nardi , M. and Caregaro , L. 2008 . Sugar cane policosanol failed to lower plasma cholesterol in primitive, diet-resistant hypercholesterolaemia: A double blind, controlled study . Complement. Ther. Med. , 16 ( 2 ) : 61 – 65 .
  • Frederiksen , H. , Mortensen , A. , Schroder , M. , Frandsen , H. , Bysted , A. , Knuthsen , P. and Rasmussen , S. E. 2007 . Effects of red grape skin and seed extract supplementation on atherosclerosis in Watanabe heritable hyperlipidemic rabbits . Mol. Nutr. Food Res. , 51 ( 5 ) : 564 – 571 .
  • Fukasawa , T. , Kamei , A. , Watanabe , Y. , Koga , J. and Abe , K. 2010 . Short-chain fructooligosaccharide regulates hepatic peroxisome proliferator-activated receptor alpha and farnesoid X receptor target gene expression in rats . J. Agric. Food Chem. , 58 ( 11 ) : 7007 – 7012 .
  • Gani , O. A. B. S. M. and Sylte , I. 2008 . Molecular recognition of Docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-X receptor alpha . J. Mol. Graph. Model. , 27 ( 2 ) : 217 – 224 .
  • Gerin , I. , Clerbaux , L. A. , Haumont , O. , Lanthier , N. , Das , A. K. , Burant , C. F. , Leclercq , I. A. , MacDougald , O. A. and Bommer , G. T. 2010 . Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation . J. Biolog. Chem. , 285 ( 44 ) : 33652 – 33661 .
  • Gonzalez-Santiago , M. , Martin-Bautista , E. , Carrero , J. J. , Fonolla , J. , Baro , L. , Bartolome , M. V. , Gil-Loyzaga , P. and Lopez-Huertas , E. 2006 . One-month administration of hydroxytyrosol, a phenolic antioxidant present in olive oil, to hyperlipemic rabbits improves blood lipid profile, antioxidant status and reduces atherosclerosis development . Atherosclerosis , 188 ( 1 ) : 35 – 42 .
  • Granados-Principal , S. , Quiles , J. L. , Ramirez-Tortosa , C. L. , Sanchez-Rovira , P. and Ramirez-Tortosa , M. C. 2010 . Hydroxytyrosol: from laboratory investigations to future clinical trials . Nutr. Rev. , 68 ( 4 ) : 191 – 206 .
  • Gresele , P. , Cerletti , C. , Guglielmini , G. , Pignatelli , P. , de Gaetano , G. and Violi , F. 2011 . Effects of resveratrol and other wine polyphenols on vascular function: an update . J. Nutr. Biochem. , 22 ( 3 ) : 201 – 211 .
  • Greyling , A. , De Witt , C. , Oosthuizen , W. and Jerling , J. C. 2006 . Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects . Br. J. Nutr. , 95 ( 5 ) : 968 – 975 .
  • Groot , P. H. E. , Pearce , N. J. , Yates , J. W. , Stocker , C. , Sauermelch , C. , Doe , C. P. , Willette , R. N. , Olzinski , A. , Peters , T. , d’Epagnier , D. , Morasco , K. O. , Krawiec , J. A. , Webb , C. L. , Aravindhan , K. , Jucker , B. , Burgert , M. , Ma , C. , Marino , J. P. , Collins , J. L. , Macphee , C. H. , Thompson , S. K. and Jaye , M. 2005 . Synthetic LXR agonists increase LDL in CETP species . J. Lipid Res. , 46 ( 10 ) : 2182 – 2191 .
  • Guan , L. , Chung , H. Y. and Chen , Z. Y. 2011 . Comparison of hypocholesterolemic acitivity of tea seed oil with commonly used vegetable oils in hamsters . J. Food Biochem. , 35 ( 3 ) : 859 – 876 .
  • Guan , L. , Chung , H. Y. , Su , Y. L. , Jiao , R. , Peng , C. and Chen , Z. Y. 2010 . Hypocholesterolemic activity of onion is mediated by enhancing excretion of fecal sterols in hamsters . Food Funct. , 1 ( 1 ) : 84 – 89 .
  • Guan , L. , Yeung , S. Y. V. , Huang , Y. and Chen , Z. Y. 2006 . Both soybean and kudzu phytoestrogens modify favorably the blood lipoprotein profile in ovariectomized and castrated hamsters . J. Agric. Food Chem. , 54 ( 13 ) : 4907 – 4912 .
  • Gunness , P. and Gidley , M. J. 2010 . Mechanisms underlying the cholesterol-lowering properties of soluble dietary fibre polysaccharides . Food Funct. , 1 ( 2 ) : 149 – 155 .
  • Gupta , S. , Pandak , W. M. and Hylemon , P. B. 2002 . LXR alpha is the dominant regulator of CYP7A1 transcription . Biochem. Biophys. Res. Commun. , 293 ( 1 ) : 338 – 343 .
  • Guzel-Seydim , Z. B. , Kok-Tas , T. , Greene , A. K. and Seydim , A. C. 2011 . Review: Functional properties of Kefir . Crit. Rev. Food Sci. Nutr. , 51 ( 3 ) : 261 – 268 .
  • Hansel , B. , Nicolle , C. , Lalanne , F. , Tondu , F. , Lassel , T. , Donazzolo , Y. , Ferrieres , J. , Krempf , M. , Schlienger , J. L. , Verges , B. , Chapman , M. J. and Bruckert , E. 2007 . Effect of low-fat, fermented milk enriched with plant sterols on serum lipid profile and oxidative stress in moderate hypercholesterolemia . Am. J. Clin. Nutr. , 86 ( 3 ) : 790 – 796 .
  • Heber , D. , Yip , I. , Ashley , J. M. , Elashoff , D. A. , Elashoff , R. M. and Go , V. L. W. 1999 . Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement . Am. J. Clin. Nutr. , 69 ( 2 ) : 231 – 236 .
  • Hiwatashi , K. , Kosaka , Y. , Suzuki , N. , Hata , K. , Mukaiyama , T. , Sakamoto , K. , Shirakawa , H. and Komai , M. 2010 . Yamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat diet . Biosci. Biotechnol. Biochem. , 74 ( 7 ) : 1447 – 1451 .
  • Hodson , L. and Frayn , K. N. 2011 . Hepatic fatty acid partitioning . Curr. Opin. Lipidol. , 22 ( 3 ) : 216 – 224 .
  • Horie , T. , Ono , K. , Horiguchi , M. , Nishi , H. , Nakamura , T. , Nagao , K. , Kinoshita , M. , Kuwabara , Y. , Marusawa , H. , Iwanaga , Y. , Hasegawa , K. , Yokode , M. , Kimura , T. and Kita , T. 2010 . MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo . Proc. Natl. Acad. Sci. USA. , 107 ( 40 ) : 17321 – 17326 .
  • Hosomi , R. , Fukunaga , K. , Arai , H. , Kanda , S. , Nishiyama , T. and Yoshida , M. 2011 . Fish protein decreases serum cholesterol in rats by inhibition of cholesterol and bile acid absorption . J. Food Sci. , 76 ( 4 ) : H116 – H121 .
  • Hosomi , R. , Fukunaga , K. , Arai , H. , Nishiyama , T. and Yoshida , M. 2009 . Effects of dietary fish protein on serum and liver lipid concentrations in rats and the expression of hepatic genes involved in lipid metabolism . J. Agric. Food Chem. , 57 ( 19 ) : 9256 – 9262 .
  • Howell , G. III , Deng , X. , Yellaturu , C. , Park , E. A. , Wilcox , H. G. , Raghow , R. and Elam , M. B. 2009 . N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXR alpha . Biochim. Biophys. Acta-Mol. Cell Biol. Lipids , 1791 ( 12 ) : 1190 – 1196 .
  • Hsu , C. L. , Wu , C. H. , Huang , S. L. and Yen , G. C. 2009 . Phenolic compounds rutin and o-coumaric acid ameliorate obesity induced by high-fat diet in rats . J. Agric. Food Chem. , 57 ( 2 ) : 425 – 431 .
  • Ikeda , I. , Tsuda , K. , Suzuki , Y. , Kobayashi , M. , Unno , T. , Tomoyori , H. , Goto , H. , Kawata , Y. , Imaizumi , K. , Nozawa , A. and Kakuda , T. 2005 . Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats . J. Nutr. , 135 ( 2 ) : 155 – 159 .
  • Ikeda , I. , Yamahira , T. , Kato , M. and Ishikawa , A. 2010 . Black-tea polyphenols decrease micellar solubility of cholesterol in vitro and intestinal absorption of cholesterol in rats . J. Agric. Food Chem. , 58 ( 15 ) : 8591 – 8595 .
  • Inoue , N. , Nagao , K. , Sakata , K. , Yamano , N. , Gunawardena , P. E. R. , Han , S. Y. , Matsui , T. , Nakamori , T. , Furuta , H. , Takamatsu , K. and Yanagita , T. 2011 . Screening of soy protein-derived hypotriglyceridemic di-peptides in vitro and in vivo . Lipids Health Dis. , 10 : 85 DOI: 10.1186/1476-511X-10-85
  • Jain , K. S. , Kathiravan , M. K. , Somani , R. S. and Shishoo , C. J. 2007 . The biology and chemistry of hyperlipidemia . Bioorganic Med. Chem. , 15 ( 14 ) : 4674 – 4699 .
  • Jemai , H. , El Feki , A. and Sayadi , S. 2009 . Antidiabetic and antioxidant effects of hydroxytyrosol and oleuropein from olive leaves in alloxan-diabetic rats . J. Agric. Food Chem. , 57 ( 19 ) : 8798 – 8804 .
  • Jemai , H. , Fki , I. , Bouaziz , M. , Bouallagui , Z. , El Feki , A. , Isoda , H. and Sayadi , S. 2008 . Upid-lowering and antioxidant effects of hydroxytyrosol and its triacetylated derivative recovered from olive tree leaves in cholesterol-fed rats . J. Agric. Food Chem. , 56 ( 8 ) : 2630 – 2636 .
  • Jeun , J. , Jung , H. , Kim , J. H. , Kim , Y. O. , Youn , S. H. and Shin , C. S. 2008 . Effect of the monascus pigment threonine derivative on regulation of the cholesterol level in mice . Food Chem. , 107 ( 3 ) : 1078 – 1085 .
  • Jeun , J. , Kim , S. , Cho , S. Y. , Jun , H. J. , Park , H. J. , Seo , J. G. , Chung , M. J. and Lee , S. J. 2010 . Hypocholesterolemic effects of Lactobacillus plantarum KCTC3928 by increased bile acid excretion in C57BL/6 mice . Nutrition , 26 ( 3 ) : 321 – 330 .
  • Jia , L. , Betters , J. L. and Yu , L. Q. 2011 . Niemann-pick C1-Like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport . Annu. Rev. Physiol. , 73 : 239 – 259 .
  • Jiao , R. , Zhang , Z. S. , Yu , H. J. , Huang , Y. and Chen , Z. Y. 2010 . Hypocholesterolemic activity of grape seed proanthocyanidin is mediated by enhancement of bile acid excretion and up-regulation of CYP7A1 . J. Nutr. Biochem. , 21 ( 11 ) : 1134 – 1139 .
  • Jou , P. C. , Ho , B. Y. , Hsu , Y. W. and Pan , T. M. 2010 . J. Agric. Food Chem. , 58 ( 24 ) : T3 – L1 . 12703 – 12709 . The effect of monascus secondary polyketide metabolites, monascin and ankaflavin, on adipogenesis and lipolysis activity in 3
  • Jump , D. B. , Botolin , D. , Wang , Y. , Xu , J. H. , Christian , B. and Demeure , O. 2005 . Fatty acid regulation of hepatic gene transcription . J. Nutr. , 135 ( 11 ) : 2503 – 2506 .
  • Kalaivani , M. , Sabitha , R. , Kalaiselvan , V. and Rajasekaran , A. 2010 . Health benefits and clinical impact of major nutrient, red yeast rice: A review . Food Bioprocess Technol. , 3 ( 3 ) : 333 – 339 .
  • Kassis , A. N. , Marinangeli , C. P. F. , Jain , D. , Ebine , N. and Jones , P. J. H. 2007 . Lack of effect of sugar cane policosanol on plasma cholesterol in golden syrian hamsters . Atherosclerosis , 194 ( 1 ) : 153 – 158 .
  • Kato , M. , Ogawa , H. , Kishida , T. and Ebihara , K. 2009 . The mechanism of the cholesterol-lowering effect of water-insoluble fish protein in ovariectomised rats . Br. J. Nutr. , 102 ( 6 ) : 816 – 824 .
  • Kato , M. , Ogawa , H. , Kishida , T. and Ebihara , K. 2011 . Hypocholesterolaemic effect of water-insoluble fish protein from Alaska pollock in ovariectomised rats is not abolished by methionine addition . Br. J. Nutr. , 106 ( 1 ) : 57 – 62 .
  • Kelly , R. B. 2010 . Diet and exercise in the management of hyperlipidemia . Am. Fam. Phys. , 81 ( 9 ) : 1097 – 1102 .
  • Kennedy , M. A. , Venkateswaran , A. , Tarr , P. T. , Xenarios , I. , Kudoh , J. , Shimizu , N. and Edwards , P. A. 2001 . Characterization of the human ABCG1 gene - liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein . J. Biolog. Chem. , 276 ( 42 ) : 39438 – 39447 .
  • Khoo , Y. S. K. and Aziz , Z. 2009 . Garlic supplementation and serum cholesterol: a meta-analysis . J. Clin. Pharm. Ther. , 34 ( 2 ) : 133 – 145 .
  • Kim , K. H. 1997 . Regulation of mammalian acetyl-coenzyme A carboxylase . Annu. Rev. Nutr. , 17 : 77 – 99 .
  • Kim , M. J. and Kim , H. K. 2009 . Perilla leaf extract Ameliorates obesity and dyslipidemia induced by high-fat diet . Phytother. Res. , 23 ( 12 ) : 1685 – 1690 .
  • Kim , M. J. , Park , M. , Jeong , M. K. , Yeo , J. , Cho , W. I. , Chang , P. S. , Chung , J. H. and Lee , J. 2010 . Radical scavenging activity and anti-obesity effects in 3T3-L1 preadipocyte differentiation of Ssuk (Artemisia princeps Pamp.) extract . Food Sci. Biotechnol. , 19 ( 2 ) : 535 – 540 .
  • Kohno , M. , Hirotsuka , M. , Kito , M. and Matsuzawa , Y. 2006 . Decreases in serum triacylglycerol and visceral fat mediated by dietary soybean beta-conglycinin . J. Atheroscler. Thromb. , 13 ( 5 ) : 247 – 255 .
  • Koya-Miyata , S. , Arai , N. , Mizote , A. , Taniguchi , Y. , Ushio , S. , Iwaki , K. and Fukuda , S. 2009 . Propolis prevents diet-induced hyperlipidemia and mitigates weight gain in diet-induced obesity in mice . Biolog. Pharmaceut. Bull. , 32 ( 12 ) : 2022 – 2028 .
  • Kroon , P. A. , Iyer , A. , Chunduri , P. , Chan , V. and Brown , L. 2010 . The cardiovascular nutrapharmacology of resveratrol: Pharmacokinetics, molecular mechanisms and therapeutic potential . Curr. Med. Chem. , 17 ( 23 ) : 2442 – 2455 .
  • Kuo , D. H. , Yeh , C. H. , Shieh , P. C. , Cheng , K. C. , Chen , F. A. and Cheng , J. T. 2009 . Effect of ShanZha, a Chinese herbal product, on obesity and dyslipidemia in hamsters receiving high-fat diet . J. Ethnopharmacol. , 124 ( 3 ) : 544 – 550 .
  • Kwon , M. J. , Song , Y. S. , Choi , M. S. , Park , S. J. , Jeong , K. S. and Song , Y. O. 2003 . Cholesteryl ester transfer protein activity and atherogenic parameters in rabbits supplemented with cholesterol and garlic powder . Life Sci. , 72 ( 26 ) : 2953 – 2964 .
  • Laffitte , B. A. , Repa , J. J. , Joseph , S. B. , Wilpiltz , D. C. , Kast , H. R. , Mangelsdorf , D. J. and Tontonoz , P. 2001 . LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes . Proc. Nat. Acad. Sci. USA. , 98 ( 2 ) : 507 – 512 .
  • Lam , C. K. , Zhang , Z. S. , Yu , H. J. , Tsang , S. Y. , Huang , Y. and Chen , Z. Y. 2008 . Apple polyphenols inhibit plasma CETP activity and reduce the ratio of non-HDL to HDL cholesterol . Mol. Nutr. Food Res. , 52 ( 8 ) : 950 – 958 .
  • Lasuncion , M. A. , Castilla , P. , Echarri , R. , Davalos , A. , Cerrato , F. , Ortega , H. , Teruel , J. L. , Lucas , M. F. , Gomez-Coronado , D. and Ortuno , J. 2006 . Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects . Am. J. Clin. Nutr. , 84 ( 1 ) : 252 – 262 .
  • Lee , H. J. , Chen , C. C. , Chou , F. P. , Wu , C. H. , Lai , F. S. , Yang , M. Y. and Wang , C. J. 2010 . Water extracts from Nelumbo Nucifera leaf reduced plasma lipids and atherosclerosis in cholesterol-fed rabbits . J. Food Biochem. , 34 ( 4 ) : 779 – 795 .
  • Lee , M-S , Kim , C-T , Kim , I-H and Kim , Y . 2009 . Inhibitory effects of green tea catechin on the lipid accumulation in 3T3-L1 adipocytes . Phytother. Res. , 23 ( 8 ) : 1088 – 1091 .
  • Lee , M-S , Park , J-Y , Freake , H. , Kwun , I.-S. and Kim , Y. 2008a . Green tea catechin enhances cholesterol 7 alpha-hydroxylase gene expression in HepG2 cells . Br. J. Nutr. , 99 ( 6 ) : 1182 – 1185 .
  • Lee , S. M. , Kim , C. W. , Kim , J. K. , Shin , H. J. and Baik , J. H. 2008b . GCG-Rich tea catechins are effective in lowering cholesterol and triglyceride concentrations in hyperlipidemic rats . Lipids , 43 ( 5 ) : 419 – 429 .
  • Lee , Y-S , Cha , B-Y , Saitoa , K. , Choi , S.-S. , Wanga , X. X. , Choi , B.-K. , Yonezawa , T. , Teruya , T. , Nagai , K. and Woo , J.-T. 2011 . Effects of a Citrus depressa Hayata (shiikuwasa) extract on obesity in high-fat diet-induced obese mice . Phytomedicine , : 648 – 654 .
  • Li , C. and Uppal , M. 2010 . Canadian diabetes association national nutrition committee clinical update on dietary fibre in diabetes: Food sources to physiological effects . Can. J. Diabetes , 34 ( 4 ) : 355 – 361 .
  • Li , C. L. , Zhu , Y. , Wang , Y. Y. , Zhu , J. S. , Chang , J. and Kritchevsky , D. 1998 . Monascus purpureus-fermented rice (red yeast rice): A natural food product that lowers blood cholesterol in animal models of hypercholesterolemia . Nutr. Res. , 18 ( 1 ) : 71 – 81 .
  • Liu , J. , Zhang , J. , Shi , Y. , Grimsgaard , S. , Alraek , T. and Fonnebo , V. 2006 . Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: a meta-analysis of randomized controlled trials . Chin. Med. , 1 ( 4 )
  • Liu , L. J. and Yeh , Y. Y. 2002 . S-alk(en)yl cysteines of garlic inhibit cholesterol synthesis by deactivating HMG-CoA reductase in cultured rat hepatocytes . J. Nutr. , 132 ( 6 ) : 1129 – 1134 .
  • Liu , L. K. , Chou , F. P. , Chen , Y. C. , Chyau , C. C. , Ho , H. H. and Wang , C. J. 2009 . Effects of Mulberry (Morus alba L.) extracts on lipid homeostasis in vitro and in vivo . J. Agric. Food Chem. , 57 ( 16 ) : 7605 – 7611 .
  • Liu , R. H. 2004 . Potential synergy of phytochemicals in cancer prevention: Mechanism of action . J. Nutr. , 134 ( 12 ) : 3479s – 3485s .
  • Lu , B. Y. , Xia , D. Z. , Huang , W. S. , Wu , X. Q. , Zhang , Y. and Yao , Y. Y. 2010 . Hypolipidemic effect of bamboo shoot oil (P. pubescens) in sprague-dawley rats . J. Food Sci. , 75 ( 6 ) : H205 – H211 .
  • Lu , C. H. and Hwang , L. S. 2008 . Polyphenol contents of Pu-Erh teas and their abilities to inhibit cholesterol biosynthesis in Hep G2 cell line . Food Chem. , 111 ( 1 ) : 67 – 71 .
  • Lynes , M. D. and Widmaier , E. P. 2011 . Involvement of CD36 and intestinal alkaline phosphatases in fatty acid transport in enterocytes, and the response to a high-fat diet . Life Sci. , 88 ( 9–10 ) : 384 – 391 .
  • Ma , Y. and Xiong , Y. L. 2009 . Antioxidant and bile acid binding activity of buckwheat protein in vitro digests . J. Agric. Food Chem. , 57 ( 10 ) : 4372 – 4380 .
  • Makni , M. , Fetoui , H. , Garoui , E. , Gargouri , N. K. , Jaber , H. , Makni , J. , Boudawara , T. and Zeghal , N. 2010 . Hypolipidemic and hepatoprotective seeds mixture diet rich in omega-3 and omega-6 fatty acids . Food Chem. Toxicol. , 48 ( 8–9 ) : 2239 – 2246 .
  • Manach , C. , Scalbert , A. , Morand , C. , Remesy , C. and Jimenez , L. 2004 . Polyphenols: food sources and bioavailability . Am. J. Clin. Nutr. , 79 ( 5 ) : 727 – 747 .
  • Marangoni , F. and Poli , A. 2010 . Phytosterols and cardiovascular health . Pharmacolog. Res. , 61 ( 3 ) : 193 – 199 .
  • Marinangeli , C. P. F. , Jones , P. J. H. , Kassis , A. N. and Eskin , M. N.A. 2010 . Policosanols as nutraceuticals: Fact or fiction . Crit. Rev. Food Sci. Nutrition , 50 ( 3 ) : 259 – 267 .
  • Marquart , T. J. , Allen , R. M. , Ory , D. S. and Baldan , A. 2010 . miR-33 links SREBP-2 induction to repression of sterol transporters . Proc. Nat. Acad. Sci. USA. , 107 ( 27 ) : 12228 – 12232 .
  • Massaro , M. , Scoditti , E. , Carluccio , M. A. and De Caterina , R. 2010 . Nutraceuticals and prevention of atherosclerosis: Focus on omega-3 Polyunsaturated fatty acids and mediterranean diet polyphenols . Cardiovasc. Ther. , 28 ( 4 ) : e13 – e19 .
  • Matsumoto , K. , Yokoyama , S. and Gato , N. 2010 . Bile acid-binding activity of young persimmon (Diospyros kaki) fruit and its hypolipidemic effect in mice . Phytother. Res. , 24 ( 2 ) : 205 – 210 .
  • Matsuo , M. 2010 . ATP-binding cassette proteins involved in glucose and lipid homeostasis . Biosci. Biotechnol. Biochem. , 74 ( 5 ) : 899 – 907 .
  • Maxfield , F. R. and Tabas , I. 2005 . Role of cholesterol and lipid organization in disease . Nature , 438 ( 7068 ) : 612 – 621 .
  • Medina-Gomez , G. , Gray , S. L. , Yetukuri , L. , Shimomura , K. , Virtue , S. , Campbell , M. , Curtis , R. K. , Jimenez-Linan , M. , Blount , M. , Yeo , G. S. H. , Lopez , M. , Seppanen-Laakso , T. , Ashcroft , F. M. , Oresic , M. and Vidal-Puig , A. 2007 . PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism . Plos Genet. , 3 ( 4 ) : e64 DOI: 10.1371/journal.pgen.0030064
  • Metzger , B. T. , Barnes , D. M. and Reed , J. D. 2007 . Insoluble fraction of buckwheat (Fagopyrum esculentum moench) protein possessing cholesterol-binding properties that reduce micelle cholesterol solubility and uptake by caco-2 cells . J. Agric. Food Chem. , 55 ( 15 ) : 6032 – 6038 .
  • Micallef , M. A. and Garg , M. L. 2009 . Beyond blood lipids: phytosterols, statins and omega-3 polyunsaturated fatty acid therapy for hyperlipidemia . J. Nutr. Biochem. , 20 ( 12 ) : 927 – 939 .
  • Miceli , N. , Mondello , M. R. , Monforte , M. T. , Sdrafkakis , V. , Dugo , P. , Crupi , M. L. , Taviano , M. F. , De Pasquale , R. and Trovato , A. 2007 . Hypolipidemic effects of citrus bergamia Risso et Poiteau juice in rats fed a hypercholesterolemic diet . J. Agric. Food Chem. , 55 ( 26 ) : 10671 – 10677 .
  • Miettinen , T. A. and Gylling , H. 1999 . Regulation of cholesterol metabolism by dietary plant sterols . Curr. Opin. Lipidol. , 10 ( 1 ) : 9 – 14 .
  • Mitka , M. 2011 . CETP inhibition shows promise as way to reduce cardiovascular disease risk . Jama-J. Am. Med. Assoc. , 305 ( 2 ) : 136 – 137 .
  • Mizutani , T. , Inatomi , S. , Inazu , A. and Kawahara , E. 2010 . Hypolipidemic effect of Pleurotus eryngii extract in fat-loaded mice . J. Nutr. Sci. Vitaminol. , 56 ( 1 ) : 48 – 53 .
  • Mori , T. , Kondo , H. , Hase , T. , Tokimitsu , I. and Murase , T. 2007 . Dietary fish oil upregulates intestinal lipid metabolism and reduces body weight gain in C57BL/6J Mice . J. Nutr. , 137 ( 12 ) : 2629 – 2634 .
  • Najafi-Shoushtari , S. H. , Kristo , F. , Li , Y. X. , Shioda , T. , Cohen , D. E. , Gerszten , R. E. and Naar , A. M. 2010 . MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis . Science , 328 ( 5985 ) : 1566 – 1569 .
  • Narayan , B. , Yamaguchi , K. , Hosokawa , M. , Fukunaga , K. , Nishiyama , T. and Miyashita , K. 2009 . Effect of marine protein supplementation on lipid profile of growing rats compared to soybean protein and casein . Food Sci. Biotechnol. , 18 ( 6 ) : 1330 – 1335 .
  • Odbayar , T. O. , Badamhand , D. , Kimura , T. , Takahashi , Y. , Tsushida , T. and Ide , T. 2006 . Comparative studies of some phenolic compounds (quercetin, rutin, and ferulic acid) affecting hepatic fatty acid synthesis in mice . J. Agric. Food Chem. , 54 ( 21 ) : 8261 – 8265 .
  • Oh , H. T. , Chung , M. J. , Kim , S. H. , Choi , H. J. and Ham , S. S. 2009 . Masou salmon (Oncorhynchus masou) ethanol extract decreases 3-hydroxy-3-methylglutaryl coenzyme A reductase expression in diet-induced obese mice . Nutr. Res. , 29 ( 2 ) : 123 – 129 .
  • Oliaro-Bosso , S. , Gaudino , E. C. , Mantegna , S. , Giraudo , E. , Meda , C. , Viola , F. and Cravotto , G. 2009 . Regulation of HMGCoA reductase activity by policosanol and octacosadienol, a new synthetic analogue of octacosanol . Lipids , 44 ( 10 ) : 907 – 916 .
  • Oliver , W. R. , Shenk , J. L. , Snaith , M. R. , Russell , C. S. , Plunket , K. D. , Bodkin , N. L. , Lewis , M. C. , Winegar , D. A. , Sznaidman , M. L. , Lambert , M. H. , Xu , H. E. , Sternbach , D. D. , Kliewer , S. A. , Hansen , B. C. and Willson , T. M. 2001 . A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport . Proc. Nat. Acad. Sci. USA. , 98 ( 9 ) : 5306 – 5311 .
  • Ong , K. T. , Mashek , M. T. , Bu , S. Y. , Greenberg , A. S. and Mashek , D. G. 2011 . Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning . Hepatol. , 53 ( 1 ) : 116 – 126 .
  • Osada , K. , Suzuki , T. , Kawakami , Y. , Senda , M. , Kasai , A. , Sami , M. , Ohta , Y. , Kanda , T. and Ikeda , M. 2006 . Dose-dependent hypocholesterolemic actions of dietary apple polyphenol in rats fed cholesterol . Lipids , 41 ( 2 ) : 133 – 139 .
  • Parish , S. , Peto , R. , Palmer , A. , Clarke , R. , Lewington , S. , Offer , A. , Whitlock , G. , Clark , S. , Youngman , L. , Sleight , P. , Collins , R. and ISIS ISIS . 2009 . The joint effects of apolipoprotein B, apolipoprotein A(1), LDL cholesterol, and HDL cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controls . Eur. Heart J. , 30 ( 17 ) : 2137 – 2146 .
  • Park , E. , Kim , J. , Youn , H.-S. and Lee , K.-H. 2009a . Effect of onion juice supplementation on lipid and antioxidant metabolism in healthy young women . Ann. Nutr. Metab. , 55 : 442 – 442 .
  • Park , J.-H. , Seo , B.-Y. , Lee , K.-H. and Park , E. 2009b . Onion supplementation inhibits lipid peroxidation and leukocyte DNA damage due to oxidative stress in high fat-cholesterol fed male rats . Food Sci. Biotechnol. , 18 ( 1 ) : 179 – 184 .
  • Peet , D. J. , Turley , S. D. , Ma , W. Z. , Janowski , B. A. , Lobaccaro , J. M. A. , Hammer , R. E. and Mangelsdorf , D. J. 1998 . Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha . Cell , 93 ( 5 ) : 693 – 704 .
  • Petrovic , N. , Szymczak , M. and Murray , M. 2008 . Modulation of angiogenesis by omega-3 polyunsaturated fatty acids is mediated by cyclooxygenases . Blood , 111 ( 7 ) : 3514 – 3521 .
  • Phillips , G. O. and Cui , S. W. 2011 . An introduction: Evolution and finalisation of the regulatory definition of dietary fibre . Food Hydrocolloids , 25 ( 2 ) : 139 – 143 .
  • Puig , T. , Relat , J. , Marrero , P. F. , Haro , D. , Brunet , J. and Colomer , R. 2008 . Green tea catechin inhibits fatty acid synthase without stimulating carnitine palmitoyltransferase-1 or inducing weight loss in experimental animals . Anticancer Res. , 28 ( 6A ) : 3671 – 3676 .
  • Qin , X. M. , Xie , X. F. , Fan , Y. B. , Tian , J. W. , Guan , Y. F. , Wang , X. , Zhu , Y. and Wang , N. P. 2008 . Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice . Hepatol. , 48 ( 2 ) : 432 – 441 .
  • Qin , Y. , Xia , M. , Ma , J. , Hao , Y. T. , Liu , J. , Mou , H. , Cao , L. and Ling , W. H. 2009 . Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects . Am. J. Clin. Nutr. , 90 ( 3 ) : 485 – 492 .
  • Quan , H. Y. , Yuan , H. D. , Kim , D. Y. , Zhang , Y. and Chung , S. H. 2010 . Korean red ginseng attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cells . Food Sci. Biotechnol. , 19 ( 1 ) : 207 – 212 .
  • Raninen , K. , Lappi , J. , Mykkanen , H. and Poutanen , K. 2011 . Dietary fiber type reflects physiological functionality: comparison of grain fiber, inulin, and polydextrose . Nutr. Rev. , 69 ( 1 ) : 9 – 21 .
  • Rayner , K. J. , Suarez , Y. , Davalos , A. , Parathath , S. , Fitzgerald , M. L. , Tamehiro , N. , Fisher , E. A. , Moore , K. J. and Fernandez-Hernando , C. 2010 . MiR-33 contributes to the regulation of cholesterol homeostasis . Science , 328 ( 5985 ) : 1570 – 1573 .
  • Reddy , J. K. and Hashimoto , T. 2001 . Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: An adaptive metabolic system . Annu. Rev. Nutr. , 21 : 193 – 230 .
  • Reinhart , K. M. , Talati , R. , White , C. M. and Coleman , C. I. 2009 . The impact of garlic on lipid parameters: a systematic review and meta-analysis . Nutr. Res. Rev. , 22 ( 1 ) : 39 – 48 .
  • Repa , J. J. , Berge , K. E. , Pomajzl , C. , Richardson , J. A. , Hobbs , H. and Mangelsdorf , D. J. 2002 . Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta . J. Biolog. Chem. , 277 ( 21 ) : 18793 – 18800 .
  • Repa , J. J. , Liang , G. S. , Ou , J. F. , Bashmakov , Y. , Lobaccaro , J. M. A. , Shimomura , I. , Shan , B. , Brown , M. S. , Goldstein , J. L. and Mangelsdorf , D. J. 2000 . Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXR alpha and LXR beta . Genes Develop. , 14 ( 22 ) : 2819 – 2830 .
  • Repa , J. J. and Mangelsdorf , D. J. 1999 . Nuclear receptor regulation of cholesterol and bile acid metabolism . Curr. Opin. Biotechnol. , 10 ( 6 ) : 557 – 563 .
  • Revilla , E. , Maria , C. S. , Miramontes , E. , Bautista , J. , Garcia-Martinez , A. , Cremades , O. , Cert , R. and Parrado , J. 2009 . Nutraceutical composition, antioxidant activity and hypocholesterolemic effect of a water-soluble enzymatic extract from rice bran . Food Res. Int. , 42 ( 3 ) : 387 – 393 .
  • Rigamonti , E. , Parolini , C. , Marchesi , M. , Diani , E. , Brambilla , S. , Sirtori , C. R. and Chiesa , G. 2010 . Hypolipidemic effect of dietary pea proteins: Impact on genes regulating hepatic lipid metabolism . Mol. Nutr. Food Res. , 54 : S24 – S30 .
  • Rodriguez-Cantu , L. N. , Gutierrez-Uribe , J. A. , Arriola-Vucovich , J. , Diaz-De La Garza , R. I. , Fahey , J. W. and Serna-Saldivar , S. O. 2011 . Broccoli (Brassica oleracea var. italica) sprouts and extracts rich in glucosinolates and isothiocyanates affect cholesterol metabolism and genes involved in lipid homeostasis in hamsters . J. Agric. Food Chem. , 59 ( 4 ) : 1095 – 1103 .
  • Ryan , A. S. , Bailey-Hall , E. , Nelson , E. B. and Salem , N. 2009 . The hypolipidemic effect of an ethyl ester of algal-docosahexaenoic acid in rats fed a high-fructose diet . Lipids , 44 ( 9 ) : 817 – 826 .
  • Schulman , I. G. 2010 . Nuclear receptors as drug targets for metabolic disease . Adv. Drug Deliv. Rev. , 62 ( 13 ) : 1307 – 1315 .
  • Seymour , E. M. , Singer , A. A. M. , Kirakosyan , A. , Urcuyo-Llanes , D. E. , Kaufman , P. B. and Bolling , S. F. 2008 . Altered hyperlipidemia, hepatic steatosis, and hepatic peroxisome proliferator-activated receptors in rats with intake of tart cherry . J. Med. Food , 11 ( 2 ) : 252 – 259 .
  • Shah , P. K. 2007 . Inhibition of CETP as a novel therapeutic strategy for reducing the risk of atherosclerotic disease . Eur. Heart J. , 28 ( 1 ) : 5 – 12 .
  • Shimano , H. 2009 . SREBPs: physiology and pathophysiology of the SREBP family . Febs. J. , 276 ( 3 ) : 616 – 621 .
  • Shimoda , H. , Tanaka , J. , Kikuchi , M. , Fukuda , T. , Ito , H. , Hatano , T. and Yoshidao , T. 2009 . Effect of polyphenol-rich extract from walnut on diet-induced hypertriglyceridemia in mice via enhancement of fatty acid oxidation in the liver . J. Agric. Food Chem. , 57 ( 5 ) : 1786 – 1792 .
  • Shishikura , Y. , Khokhar , S. and Murray , B. S. 2006 . Effects of tea polyphenols on emulsification of olive oil in a small intestine model system . J. Agric. Food Chem. , 54 ( 5 ) : 1906 – 1913 .
  • Shukla , A. , Bettzieche , A. , Hirche , F. , Brandsch , C. , Stangl , G. I. and Eder , K. 2006 . Dietary fish protein alters blood lipid concentrations and hepatic genes involved in cholesterol homeostasis in the rat model . Br. J. Nutr. , 96 ( 4 ) : 674 – 682 .
  • Simopoulos , A. P. 2008 . The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases . Exp. Biol. Med. , 233 ( 6 ) : 674 – 688 .
  • Singh , D. K. , Banerjee , S. and Porter , T. D. 2009 . Green and black tea extracts inhibit HMG-CoA reductase and activate AMP kinase to decrease cholesterol synthesis in hepatoma cells . J. Nutr. Biochem. , 20 ( 10 ) : 816 – 822 .
  • Sirtori , C. R. , Galli , C. , Anderson , J. W. and Arnoldi , A. 2009 . Nutritional and nutraceutical approaches to dyslipidemia and atherosclerosis prevention: focus on dietary proteins . Atherosclerosis , 203 ( 1 ) : 8 – 17 .
  • Smith , L. E. H. , Connor , K. M. , SanGiovanni , J. P. , Lofqvist , C. , Aderman , C. M. , Chen , J. , Higuchi , A. , Hong , S. , Pravda , E. A. , Majchrzak , S. , Carper , D. , Hellstrom , A. , Kang , J. X. , Chew , E. Y. , Salem , N. and Serhan , C. N. 2007 . Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis . Nat. Med. , 13 ( 7 ) : 868 – 873 .
  • Spielmann , J. , Kluge , H. , Stangl , G. I. and Eder , K. 2009 . Hypolipidaemic effects of potato protein and fish protein in pigs . J. Anim. Physiol. Anim. Nutr. , 93 ( 4 ) : 400 – 409 .
  • Spielmann , J. , Stangl , G. I. and Eder , K. 2008 . Dietary pea protein stimulates bile acid excretion and lowers hepatic cholesterol concentration in rats . J. Anim. Physiol. Anim. Nutr. , 92 ( 6 ) : 683 – 693 .
  • Steck , T. L. and Lange , Y. 2010 . Cell cholesterol homeostasis: mediation by active cholesterol . Trends Cell Biol. , 20 ( 11 ) : 680 – 687 .
  • Steinberg , D. 2006 . An interpretive history of the cholesterol controversy. Part II. The early evidence linking hypercholesterolemia to coronary disease in humans (vol 46, pg 179, 2005) . J. Lipid Res. , 47 ( 9 ) : 2100 – 2100 .
  • Steinberg , G. R. and Kemp , B. E. 2009 . AMPK in health and disease . Physiolog. Rev. , 89 ( 3 ) : 1025 – 1078 .
  • Stephens , A. M. , Dean , L. L. , Davis , J. P. , Osborne , J. A. and Sanders , T. H. 2010 . Peanuts, peanut oil, and fat free peanut flour reduced cardiovascular disease risk factors and the development of atherosclerosis in syrian golden hamsters . J. Food Sci. , 75 ( 4 ) : H116 – H122 .
  • Sugiyama , H. , Akazome , Y. , Shoji , T. , Yamaguchi , A. , Yasue , M. , Kanda , T. and Ohtake , Y. 2007 . Oligomeric procyanidins in apple polyphenol are main active components for inhibition of pancreatic lipase and triglyceride absorption . J. Agric. Food Chem. , 55 ( 11 ) : 4604 – 4609 .
  • Sung , Y. Y. , Yoon , T. , Kim , S. J. , Yang , W. K. and Kim , H. K. 2011 . Anti-obesity activity of Allium fistulosum L. extract by down-regulation of the expression of lipogenic genes in high-fat diet-induced obese mice . Mol. Med. Rep. , 4 ( 3 ) : 431 – 435 .
  • Taku , K. , Lin , N. , Cai , D. , Hu , J. , Zhao , X. , Zhang , Y. , Wang , P. , Melby , M. K. , Hooper , L. , Kurzer , M. S. , Mizuno , S. , Ishimi , Y. and Watanabe , S. 2010a . Effects of soy isoflavone extract supplements on blood pressure in adult humans: systematic review and meta-analysis of randomized placebo-controlled trials . J. Hypertens. , 28 ( 10 ) : 1971 – 1982 .
  • Taku , K. , Melby , M. K. , Takebayashi , J. , Mizuno , S. , Ishimi , Y. , Omori , T. and Watanabe , S. 2010b . Effect of soy isoflavone extract supplements on bone mineral density in menopausal women: meta-analysis of randomized controlled trials . Asia Pac. J. Clin. Nutr. , 19 ( 1 ) : 33 – 42 .
  • Taku , K. , Umegaki , K. , Ishimi , Y. and Watanabe , S. 2008 . Effects of extracted soy isoflavones alone on blood total and LDL cholesterol: Meta-analysis of randomized controlled trials . Ther. Clin. Risk Manage. , 4 ( 5 ) : 1097 – 1103 .
  • Taku , K. , Umegaki , K. , Sato , Y. , Taki , Y. , Endoh , K. and Watanabe , S. 2007 . Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials . Am. J. Clin. Nutr. , 85 ( 4 ) : 1148 – 1156 .
  • Tanaka , K. , Nishizono , S. , Tamaru , S. , Kondo , M. , Shimoda , H. , Tanaka , J. and Okada , T. 2009 . Anti-obesity and hypotriglyceridemic psroperties of coffee bean extract in SD rats . Food Sci. Technol. Res. , 15 ( 2 ) : 147 – 152 .
  • Tandy , S. , Chung , R. W. S. , Wat , E. , Kamili , A. , Berge , K. , Griinari , M. and Cohn , J. S. 2009 . Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice . J. Agric. Food Chem. , 57 ( 19 ) : 9339 – 9345 .
  • Temel , R. E. , Gebre , A. K. , Parks , J. S. and Rudel , L. L. 2003 . Compared with Acyl-CoA : cholesterol O-acyltransferase (ACAT) 1 and lecithin : cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol . J. Biolog. Chem. , 278 ( 48 ) : 47594 – 47601 .
  • Theuwissen , E. and Mensink , R. P. 2008 . Water-soluble dietary fibers and cardiovascular disease . Physiol. Behav. , 94 ( 2 ) : 285 – 292 .
  • Toh , S. A. , Millar , J. S. , Billheimer , J. , Fuki , I. , Naik , S. U. , Macphee , C. , Walker , M. and Rader , D. J. 2011 . PPAR gamma activation redirects macrophage cholesterol from fecal excretion to adipose tissue uptake in mice via SR-BI . Biochem. Pharmacol. , 81 ( 7 ) : 934 – 941 .
  • Tomotake , H. , Shimaoka , I. , Kayashita , J. , Yokoyama , F. , Nakajoh , M. and Kato , N. 2000 . A buckwheat protein product suppresses gallstone formation and plasma cholesterol more strongly than soy protein isolate in hamsters . J. Nutr. , 130 ( 7 ) : 1670 – 1674 .
  • Tomotake , H. , Yamamoto , N. , Kitabayashi , H. , Kwakami , A. , Kayashita , J. , Ohinata , H. , Karasawa , H. and Kato , N. 2007 . Preparation of tartary buckwheat protein product and its improving effect on cholesterol metabolism in rats and mice fed cholesterol-enriched diet . J. Food Sci. , 72 ( 7 ) : S528 – S533 .
  • Tsai , J. S. , Lin , Y. H. , Hung , L. B. and Pan , B. S. 2011 . Plasma lipid regulatory effect of compounded freshwater clam hydrolysate and Gracilaria insoluble dietary fibre . Food Chem. , 125 ( 2 ) : 397 – 401 .
  • Tzang , B. S. , Yang , S. F. , Fu , S. G. , Yang , H. C. , Sun , H. L. and Chen , Y. C. 2009 . Effects of dietary flaxseed oil on cholesterol metabolism of hamsters . Food Chem. , 114 ( 4 ) : 1450 – 1455 .
  • van der Veen , J. N. , Kruit , J. K. , Havinga , R. , Baller , J. F. W. , Chimini , G. , Lestavel , S. , Staels , B. , Groot , P. H. E. , Groen , A. K. and Kuipers , F. 2005 . Reduced cholesterol absorption upon PPAR delta activation coincides with decreased intestinal expression of NPC1L1 . J. Lipid Res. , 46 ( 3 ) : 526 – 534 .
  • Velayutham , P. , Babu , A. and Liu , D. M. 2008 . Green tea catechins and cardiovascular health: an update . Curr. Med. Chem. , 15 ( 18 ) : 1840 – 1850 .
  • Vidyashankar , S. , Sambaiah , K. and Srinivasan , K. 2009 . Dietary garlic and onion reduce the incidence of atherogenic diet-induced cholesterol gallstones in experimental mice . Br. J. Nutr. , 101 ( 11 ) : 1621 – 1629 .
  • Vidyavati , H. G. , Manjunatha , H. , Hemavathy , J. and Srinivasan , K. 2010 . Hypolipidemic and antioxidant efficacy of dehydrated onion in experimental rats . J. Food Sci. Technol.-Mysore , 47 ( 1 ) : 55 – 60 .
  • Vijayakumar , M. V. , Pandey , V. , Mishra , G. C. and Bhat , M. K. 2010 . Hypolipidemic effect of fenugreek seeds is mediated through inhibition of fat accumulation and upregulation of LDL receptor . Obesity , 18 ( 4 ) : 667 – 674 .
  • Vrins , C. L. J. , van der Velde , A. E. , van den Oever , K. , Levels , J. H. M. , Huet , S. , Elferink , R. P. J. O. , Kuipers , F. and Groen , A. K. 2009 . Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux . J. Lipid Res. , 50 ( 10 ) : 2046 – 2054 .
  • Wagner , B. L. , Valledor , A. F. , Shao , G. , Daige , C. L. , Bischoff , E. D. , Petrowski , M. , Jepsen , K. , Baek , S. H. , Heyman , R. A. , Rosenfeld , M. G. , Schulman , I. G. and Glass , C. K. 2003 . Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression . Mol. Cell. Biol. , 23 ( 16 ) : 5780 – 5789 .
  • Wakil , S. J. , Stoops , J. K. and Joshi , V. C. 1983 . Fatty acid synyhesis and its regulation . Annu. Rev. Biochem. , 52 : 537 – 579 .
  • Wakutsu , M. , Tsunoda , N. , Shiba , S. , Muraki , E. and Kasono , K. 2010 . Peroxisome proliferator-activated receptors (PPARs)-independent functions of fish oil on glucose and lipid metabolism in diet-induced obese mice . Lipids Health Dis. , 9 ( 101 )
  • Wan , J.-B. , Huang , L.-L. , Rong , R. , Tan , R. , Wang , J. and Kang , J. X. 2010 . Endogenously decreasing tissue n-6/n-3 fatty acid ratio reduces atherosclerotic lesions in apolipoprotein E-deficient mice by inhibiting systemic and vascular inflammation . Arterioscler. Thromb. Vasc. Biol. , 30 ( 12 ) : 2487 – U282 .
  • Wang , M. , Liu , J. R. , Gao , J. M. , Parry , J. W. and Wei , Y. M. 2009a . Antioxidant activity of tartary buckwheat bran extract and its effect on the lipid profile of hyperlipidemic rats . J. Agric. Food Chem. , 57 ( 11 ) : 5106 – 5112 .
  • Wang , S. , Noh , S. K. and Koo , S. I. 2006 . Green tea catechins inhibit pancreatic phospholipase A(2) and intestinal absorption of lipids in ovariectomized rats . J. Nutr. Biochem. , 17 ( 7 ) : 492 – 498 .
  • Wang , S. , Wu , D. Y. , Matthan , N. R. , Lamon-Fava , S. , Lecker , J. L. and Lichtenstein , A. H. 2009b . Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse . Atherosclerosis , 204 ( 1 ) : 147 – 155 .
  • Wang , Y. , Kurdi-Haidar , B. and Oram , J. F. 2004a . LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1 . J. Lipid Res. , 45 ( 5 ) : 972 – 980 .
  • Wang , Y. X. , Zhang , C. L. , Yu , R. T. , Cho , H. K. , Nelson , M. C. , Bayuga-Ocampo , C. R. , Ham , J. , Kang , H. and Evans , R. M. 2004b . Regulation of muscle fiber type and running endurance by PPAR delta . Plos Biol. , 2 ( 10 ) : 1532 – 1539 .
  • Wang , Z. M. , Zhou , B. , Wang , Y. S. , Gong , Q. Y. , Wang , Q. M. , Yan , J. J. , Gao , W. and Wang , L. S. 2011 . Black and green tea consumption and the risk of coronary artery disease: a meta-analysis . Am. J. Clin. Nutr. , 93 ( 3 ) : 506 – 515 .
  • Wat , E. , Tandy , S. , Kapera , E. , Kamili , A. , Chung , R. W. S. , Brown , A. , Rowney , M. and Cohn , J. S. 2009 . Dietary phospholipid-rich dairy milk extract reduces hepatomegaly, hepatic steatosis and hyperlipidemia in mice fed a high-fat diet . Atherosclerosis , 205 ( 1 ) : 144 – 150 .
  • Way , T. D. , Lin , H. Y. , Kuo , D. H. , Tsai , S. J. , Shieh , J. C. , Wu , J. C. , Lee , M. R. and Lin , J. K. 2009 . Pu-erh tea attenuates hyperlipogenesis and induces hepatoma cells growth arrest through activating AMP-activated protein kinase (AMPK) in human HepG2 cells . J. Agric. Food Chem. , 57 ( 12 ) : 5257 – 5264 .
  • Wei , Z. H. , Wang , H. , Chen , X. Y. , Wang , B. S. , Rong , Z. X. , Wang , B. S. , Su , B. H. and Chen , H. Z. 2009 . Time- and dose-dependent effect of psyllium on serum lipids in mild-to-moderate hypercholesterolemia: a meta-analysis of controlled clinical trials . Eur. J. Clin. Nutr. , 63 ( 7 ) : 821 – 827 .
  • Weisse , K. , Brandsch , C. , Zernsdorf , B. , Nembongwe , G. S. N. , Hofmann , K. , Eder , K. and Stangl , G. I. 2010 . Lupin protein compared to casein lowers the LDL cholesterol:HDL cholesterol-ratio of hypercholesterolemic adults . Eur. J. Nutr. , 49 ( 2 ) : 65 – 71 .
  • Wolever , T. M. S. , Tosh , S. M. , Gibbs , A. L. , Brand-Miller , J. , Duncan , A. M. , Hart , V. , Lamarche , B. , Thomson , B. A. , Duss , R. and Wood , P. J. 2010 . Physicochemical properties of oat beta-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial . Am. J. Clin. Nutr. , 92 ( 4 ) : 723 – 732 .
  • Wu , C. H. , Yang , M. Y. , Chan , K. C. , Chung , P. J. , Ou , T. T. and Wang , C. J. 2010 . Improvement in high-fat diet-induced obesity and body fat accumulation by a Nelumbo nucifera leaf flavonoid-rich extract in mice . J. Agric. Food Chem. , 58 ( 11 ) : 7075 – 7081 .
  • Yahagi , N. , Shimano , H. , Hasty , A. H. , Amemiya-Kudo , M. , Okazaki , H. , Tamura , Y. , Iizuka , Y. , Shionoiri , F. , Ohashi , K. , Osuga , J. , Harada , K. , Gotoda , T. , Nagai , R. , Ishibashi , S. and Yamada , N. 1999 . A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids . J. Biolog. Chem. , 274 ( 50 ) : 35840 – 35844 .
  • Yamamoto , Y. and Yasuoka , A. 2010 . Welsh onion attenuates hyperlipidemia in rats fed on high-fat high-sucrose diet . Biosci. Biotechnol. Biochem. , 74 ( 2 ) : 402 – 404 .
  • Yang , D. J. , Chang , Y. Y. , Hsu , C. L. , Liu , C. W. , Lin , Y. L. , Lin , Y. H. , Liu , K. C. and Chen , Y. C. 2010a . Antiobesity and hypolipidemic effects of polyphenol-rich longan (Dimocarpus longans Lour.) flower water extract in hypercaloric-dietary rats . J. Agric. Food Chem. , 58 ( 3 ) : 2020 – 2027 .
  • Yang , D. J. , Chang , Y. Y. , Hsu , C. L. , Liu , C. W. , Wang , Y. and Chen , Y. C. 2010b . Protective effect of a litchi (Litchi chinensis Sonn.)-flower-water-extract on cardiovascular health in a high-fat/cholesterol-dietary hamsters . Food Chem. , 119 ( 4 ) : 1457 – 1464 .
  • Yang , M. Y. , Peng , C. H. , Chan , K. C. , Yang , Y. S. , Huang , C. N. and Wang , C. J. 2010c . The hypolipidemic effect of hibiscus sabdariffa polyphenols via inhibiting lipogenesis and promoting hepatic lipid clearance . J. Agric. Food Chem. , 58 ( 2 ) : 850 – 859 .
  • Yang , S. F. , Tseng , J. K. , Chang , Y. Y. and Chen , Y. C. 2009 . Flaxseed oil attenuates nonalcoholic fatty liver of hyperlipidemic hamsters . J. Agric. Food Chem. , 57 ( 11 ) : 5078 – 5083 .
  • Yasuda , A. , Natsume , M. , Osakabe , N. , Kawahata , K. and Koga , J. 2011 . Cacao polyphenols influence the regulation of apolipoprotein in HepG2 and Caco2 cells . J. Agric. Food Chem. , 59 ( 4 ) : 1470 – 1476 .
  • Yeo , C. R. , Yang , C. , Wong , T. Y. and Popovich , D. G. 2011 . A quantified ginseng (Panax ginseng C. A. Meyer) extract influences lipid acquisition and increases adiponectin expression in 3T3-L1 cells . Molecules , 16 ( 1 ) : 477 – 492 .
  • Yiu , W. F. , Kwan , P. L. , Wong , C. Y. , Kam , T. S. , Chiu , S. M. , Chan , S. W. and Chan , R. 2011 . Attenuation of fatty liver and prevention of hypercholesterolemia by extract of curcuma longa through regulating the expression of CYP7A1, LDL-receptor, HO-1, and HMG-CoA reductase . J. Food Sci. , 76 ( 3 ) : H80 – H89 .
  • Yoshikawa , T. , Shimano , H. , Yahagi , N. , Ide , T. , Amemiya-Kudo , M. , Matsuzaka , T. , Nakakuki , M. , Tomita , S. , Okazaki , H. , Tamura , Y. , Iizuka , Y. , Ohashi , K. , Takahashi , A. , Sone , H. , Osuga , J. , Gotoda , T. , Ishibashi , S. and Yamada , N. 2002 . Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements . J. Biolog. Chem. , 277 ( 3 ) : 1705 – 1711 .
  • Yu , F. , Gao , J. , Zeng , Y. and Liu , C.-X. 2011 . Effects of adlay seed oil on blood lipids and antioxidant capacity in hyperlipidemic rats . J. Sci. Food Agric. , 91 ( 10 ) : 1843 – 1848 .
  • Yuan , G. , Al-Shali , K. Z. and Hegele , R. A. 2007 . Hypertriglyceridemia: its etiology, effects and treatment . Can. Med. Assoc. J. , 176 ( 8 ) : 1113 – 1120 .
  • Yuan , H. D. , Kim , S. J. , Quan , H. Y. , Huang , B. and Chung , S. H. 2010 . Ginseng leaf extract prevents high fat diet-induced hyperglycemia and hyperlipidemia through AMPK activation . J. Ginseng Res. , 34 ( 4 ) : 369 – 375 .
  • Zelcer , N. , Hong , C. , Boyadjian , R. and Tontonoz , P. 2009 . LXR regulates cholesterol uptake through idol-dependent ubiquitination of the LDL receptor . Science , 325 ( 5936 ) : 100 – 104 .
  • Zern , T. L. , West , K. L. and Fernandez , M. L. 2003 . Grape polyphenols decrease plasma triglycerides and cholesterol accumulation in the aorta of ovariectomized guinea pigs . J. Nutr. , 133 ( 7 ) : 2268 – 2272 .
  • Zern , T. L. , Wood , R. J. , Greene , C. , West , K. L. , Liu , Y. Z. , Aggarwal , D. , Shachter , N. S. and Fernandez , M. L. 2005 . Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress . J. Nutr. , 135 ( 8 ) : 1911 – 1917 .
  • Zhan , S. Y. and Ho , S. C. 2005 . Meta-analysis of the effects of soy protein containing isoflavones on the lipid profile . Am. J. Clin. Nutr. , 81 ( 2 ) : 397 – 408 .
  • Zhang , Z. S. , Ho , W. K. K. , Huang , Y. , James , A. E. , Lam , L. W. and Chen , Z. Y. 2002 . Hawthorn fruit is Hypolipidemic in rabbits fed a high cholesterol diet . J. Nutr. , 132 ( 1 ) : 5 – 10 .
  • Zheng , X-X , Xu , Y-L , Li , S-H , Liu , X-X , Hui , R. and Huang , X.-H. 2011 . Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomized controlled trials . Am. J. Clin. Nutr. , 94 ( 2 ) : 601 – 610 .
  • Zhuo , X. G. , Melby , M. K. and Watanabe , S. 2004 . Soy isoflavone intake lowers serum LDL cholesterol: a meta-analysis of 8 randomized controlled trials in humans . J. Nutr. , 134 ( 9 ) : 2395 – 2400 .
  • Zung , A. , Shachar , S. , Zadik , Z. and Kerem , Z. 2010 . Soy-derived isoflavones treatment in children with hypercholesterolemia: a pilot study . J. Pediatr. Endocrinol. Metab. , 23 ( 1–2 ) : 133 – 141 .

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