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Original Articles

Specificity of Infant Digestive Conditions: Some Clues for Developing Relevant In Vitro Models

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Pages 1427-1457 | Received 23 Aug 2011, Accepted 10 Nov 2011, Published online: 28 Feb 2014

REFERENCES

  • Adamson , I. , Esangbedo , A. , Okolo , A. A. and Omene , J. A. 1988 . Pepsin and its multiple forms in early life . Biol. Neonate. , 53 ( 5 ) : 267 – 273 .
  • Aguilera , J. M. 2006 . Food microstructure affects the bioavailability of several nutrients . J. Food Sci. , 72 ( 2 ) : R21 – R32 .
  • Agunod , M. , Yamaguchi , N. , Lopez , R. , Luhby , A. and Glass , G. 1969 . Correlative study of hydrochloric acid, pepsin, and intrinsic factor secretion in newborns and infants . Digest. Dis. Sci. , 14 ( 6 ) : 400 – 414 .
  • Alemi , B. , Hamosh , M. , Scanlon , J. W. , Salzman-Mann , C. and Hamosh , P. 1981 . Fat digestion in very low-birth-weight infants: Effect of addition of human milk to low-birth-weight formula . Pediatrics , 68 ( 4 ) : 484 – 489 .
  • Allen , A. and Flemström , G. 2005 . Gastroduodenal mucus bicarbonate barrier: Protection against acid and pepsin . Am. J. Physiol. Cell Physiol. , 288 ( 1 ) : C1 – C19 .
  • Amara , S. , Barouh , N. , Lecomte , J. , Lafont , D. , Robert , S. , Villeneuve , P. and Carrière , F. 2010 . Lipolysis of natural long chain and synthetic medium chain galactolipids by pancreatic lipase-related protein 2 . Biochim. Biophys. Acta. , 1801 ( 4 ) : 508 – 516 .
  • Anderson , C. A. and Berseth , C. L. 1996 . Neither motor responses nor gastric emptying vary in response to formula temperature in preterm infants . Biol. Neonate. , 70 ( 5 ) : 265 – 270 .
  • Andersson , E. , Lindquist , S. , Blackberg , L. and Hernell , O. 2011 . Bile salt-stimulated lipase and pancreatic lipase related protein 2 promote efficient lipid digestion and product absorption in the newborn . J. Pediatr. Gastroenterol. Nutr. , 48 : E87 – E88 .
  • Andersson , L. , Carrière , F. , Lowe , M. E. , Nilsson , A. and Verger , R. 1996 . Pancreatic lipase-related protein 2 but not classical pancreatic lipase hydrolyzes galactolipids . Biochim. Biophys. Acta. Lipids and Lipid Metabolism. , 1302 ( 3 ) : 236 – 240 .
  • Anson , M. L. and Mirsky , A. E. 1932 . The estimation of pepsin with hemoglobin . J. Gen. Physiol. , 16 : 59 – 63 .
  • Antonowicz , I. and Lebenthal , E. 1977 . Developmental pattern of small intestinal enterokinase and disaccharidase activities in the human fetus . Gastroenterology , 72 ( 6 ) : 1299 – 1303 .
  • Armand , M. , Hamosh , M. , DiPalma , J. S. , Gallagher , J. , Benjamin , S. B. , Philpott , J. R. , Lairon , D. and Hamosh , P. 1995 . Dietary fats modulates gastric lipase activity in healthy humans . Am. J. Clin. Nutr. , 62 : 74 – 80 .
  • Armand , M. , Hamosh , M. , Mehta , N. R. and Angelus , P. A. 1994 . Fat digestion—Gastric lipolysis is higher in mothers own milk (Mom) than in formula (F) fed very-low-birth-weight (Vlbw) infants . Pediatr. Res. , 35 ( 4 ) : A124
  • Armand , M. , Hamosh , M. , Mehta , N. R. , Angelus , P. A. , Philpott , J. R. , Henderson , T. R. , Dwyer , N. K. , Lairon , D. and Hamosh , P. 1996 . Effect of human milk or formula on gastric function and fat digestion in the premature infant . Pediatr. Res. , 40 ( 3 ) : 429 – 437 .
  • Armand , M. , Pasquier , B. , André , M. , Borel , P. , Senft , M. , Peyrot , J. , Salducci , J. , Portugal , H. , Jaussan , V. and Lairon , D. 1999 . Digestion and absorption of 2 fat emulsions with different droplet sizes in the human digestive tract . Am. J. Clin. Nutr. , 70 ( 6 ) : 1096 – 1106 .
  • Avery , G. B. , Randolph , J. G. and Weaver , T. 1966 . Gastric acidity in the first day of life . Pediatrics , 37 ( 6 ) : 1005 – 1007 .
  • Baba , T. , Downs , D. , Jackson , K. W. , Tang , J. and Wang , C. S. 1991 . Structure of human milk bile salt activated lipase . Biochemistry. , 30 ( 2 ) : 500 – 510 .
  • Back , P. and Walter , K. 1980 . Developmental pattern of bile acid metabolism as revealed by bile acid analysis of meconium . Gastroenterology , 78 ( 4 ) : 671 – 676 .
  • Balistreri , W. F. 1991 . Fetal and neonatal bile acid synthesis and metabolism—Clinical implications . J. Inheri Metab. Dis. , 14 ( 4 ) : 459 – 477 .
  • Bernback , S. , Blackberg , L. and Hernell , O. 1989 . Fatty acids generated by gastric lipase promote human milk triacylglycerol digestion by pancreatic colipase-dependent lipase . Biochim. Biophys. Acta. Lipids and Lipid Metabolism. , 1001 ( 3 ) : 286 – 293 .
  • Bernback , S. , Blackberg , L. and Hernell , O. 1990 . The complete digestion of human milk triacylglycerol in vitro requires gastric lipase, pancreatic colipase-dependent lipase and bile salt stimulated lipase . J. Clin. Invest. , 85 ( 4 ) : 1221 – 1226 .
  • Berseth , C. L. 1989 . Gestational evolution of small intestine motility in term or preterm infants . J. Pediatr. , 115 ( 4 ) : 646 – 651 .
  • Berseth , C. L. 1990 . Neonatal small intestinal motility: Motor responses to feeding in term and preterm infants . J. Pediatr. , 117 ( 5 ) : 777 – 782 .
  • Berseth , C. L. 1996 . Gastrointestinal motility in the neonate . Clin. Perinatol. , 23 ( 3 ) : 179 – 190 .
  • Berton , A. , Sebban-Kreuzer , C. , Rouvellac , S. , Lopez , C. and Crenon , I. 2009 . Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules . Mol. Nutr. Food Res. , 53 ( 12 ) : 1592 – 1602 .
  • Billeaud , C. , Guillet , J. and Sandler , B. 1990 . Gastric emptying in infants with or without gastro-oesophageal reflux according to the type of milk . Eur. J. Clin. Nutr. , 44 ( 8 ) : 577 – 583 .
  • Boehm , G. , Bierbach , U. , DelSanto , A. , Moro , G. and Minoli , I. 1995a . Activities of trypsin and lipase in duodenal aspirates of healthy preterm infants. Effects of gestational and postnatal age . Biol. Neonate. , 67 ( 4 ) : 248 – 253 .
  • Boehm , G. , Borte , M. , Muller , H. , Moro , G. and Minoli , I. 1995b . Activities of trypsin and lipase in duodenal aspirates of preterm infants: Influence of dietary protein and fat composition . Am. J. Clin. Nutr. , 61 ( 3 ) : 524 – 527 .
  • Boisen , S. and Eggum , B. O. 1991 . Critical evaluation of in vitro methods for estimating digestibility in simple-stomach animals . Nutr. Res. Rev. , 4 : 141 – 162 .
  • Borgström , B. , Erlanson-Albertsson , C. and Borgström , A. 1993 . Human pancreatic proenzymes are activated at different rates in vitro . Scand. J. Gastroenterol , 28 : 455 – 459 .
  • Borgström , B. , Erlanson-Albertsson , C. and Wieloch , T. 1979 . Pancreatic colipase: Chemistry and physiology . J. Lipid Res. , 20 ( 7 ) : 805 – 816 .
  • Borgström , B. , Lindquist , S. and Lundh , G. 1960 . Enzyme concentration and absorption of protein and glucose in duodenum of premature infants . Am. J. Dis. Child. , 99 ( 3 ) : 338 – 343 .
  • Borgström , B. , Lindquist , S. and Lundh , G. 1961 . Digestive studies in children: Studies under normal and pathological conditions . Am. J. Dis. Child. , 101 ( 4 ) : 454 – 466 .
  • Borgström , B. and Patton , J. S. 2010 . “ Luminal events in gastrointestinal lipid digestion ” . In Supplement 19: Handbook of Physiology, The Gastrointestinal System, Intestinal Absorption and Secretion. Comprehensive Physiology , Edited by: Terjung , R. 475 – 504 . New-York : John Wiley & Sons .
  • Borulf , S. , Lindberg , T. and Hansson , L. 2011 . Agarose gel electrophoresis of duodenal juice in normal condition and in children with malabsorption . Scand. J. Gastroenterol , 14 ( 2 ) : 151 – 160 .
  • Britton , J. and Koldovsky , O. 1989 . Development of luminal protein digestion: Implications for biologically active dietary polypeptides . J. Pediatr. Gastroenterol. Nutr. , 9 : 144 – 162 .
  • Brockerhoff , H. 1970 . Substrate specificity of pancreatic lipase. Influence of the structure of fatty acids on the reactivity of esters . Biochim. Biophys. Acta. , 212 ( 1 ) : 92 – 101 .
  • Brown , G. A. , Sule , D. , Williams , J. , Puntis , J. W. , Booth , I. W. and McNeish , A. S. 1988 . Faecal chymotrypsin: A reliable index of exocrine pancreatic function . Arch. Dis. Child. , 63 ( 7 ) : 785 – 789 .
  • Brueton , M. J. , Berger , H. M. , Brown , G. A. , Ablitt , L. , Iyngkaran , N. and Wharton , B. A. 1978 . Duodenal bile acid conjugation patterns and dietary sulphur amino acids in the newborn . Gut , 19 : 95 – 98 .
  • Carey , M. C. , Small , D. M. and Bliss , C. M. 1983 . Lipid digestion and absorption . Am. Rev. Physiol. , 45 : 651 – 677 .
  • Carrière , F. , Barrowman , J. A. , Verger , R. and Laugier , R. 1993 . Secretion and contribution to lipolysis of gastric and pancreatic lipases during a test meal in humans . Gastroenterology , 105 ( 3 ) : 876 – 888 .
  • Cavell , B. 1979 . Gastric emptying in preterm infants . Acta Paediatr. Scand. , 68 ( 5 ) : 725 – 730 .
  • Cavell , B. 1981 . Gastric emptying in infants fed human milk or infant formula . Acta Paediatr. Scand. , 70 ( 5 ) : 639 – 641 .
  • Cavell , B. 1983 . Posprandial gastric acid secretion in infants . Acta Paediatr. Scand. , 72 ( 6 ) : 857 – 860 .
  • Chen , Q. , Blackberg , L. , Nilsson , A. , Sternby , B. and Hernell , O. 1994 . Digestion of triacylglycerols containing long chain polyenoic fatty acids in vitro by colipase-dependent pancreatic lipase and human milk bile-salt stimulated lipase . Biochim. Biophys. Acta. , 1210 ( 2 ) : 239 – 243 .
  • Chen , Q. , Sternby , B. and Nilsson , A. 1989 . Hydrolysis of triacylglycerol arachidonic and linoleic acid ester bonds by human pancreatic lipase and carboxyl ester lipase . Biochim. Biophys. Acta. , 1004 ( 3 ) : 372 – 385 .
  • Commare , C. E. and Tappenden , K. A. 2007 . Development of the infant intestine: Implications for nutrition support . Nutr. Clin. Practice. , 22 ( 2 ) : 159 – 173 .
  • Cowen , A. E. and Campbell , C. B. 1977 . Bile salt metabolism. I. The physiology of bile salts . Austr. New-Zealand J. Med. , 7 ( 6 ) : 579 – 586 .
  • Davidson , L. , Donovan , S. , Lönnerdal , B. and Atkinson , S. A. 1989 . “ Excretion of human milk proteins by term and preterm infants ” . In Protein and Non-protein Nitrogen in Human Milk , Edited by: Atkinson , S. A. and Lönnerdal , B. 161 – 172 . Boca Raton : CRC Press .
  • De Belle , R. C. , Vaupshas , V. , Vitullo , B. B. , Haber , L. R. , Shaffer , E. , Mackie , G. G. , Owen , H. , Little , J. M. and Lester , R. 1979 . Intestinal absorption of bile salts: Immature development in the neonate . J. Pediatr. , 94 ( 3 ) : 472 – 476 .
  • DiPalma , J. , Kirk , C. , Hamosh , M. , Colon , A. R. and Hamosh , P. 1991 . Lipase and pepsin activities in the gastric mucosa of infants, children and adults . Gastroenterology , 101 ( 1 ) : 116 – 120 .
  • Dubois , A. , Eerdewegh , P. V. and Gardner , J. D. 1977 . Gastric emptying and secretion in zollinger-ellison syndrome . J. Clin. Invest. , 59 : 255 – 263 .
  • Dumont , R. C. and Rudolph , C. D. 1994 . Development of gastrointestinal motility in the infant and child . Gastroenterol. Clin. North Am. , 23 : 655 – 671 .
  • Dupont , D. , Mandalari , G. , Mollé , D. , Jardin , J. , Rolet-Répécaud , O. , Duboz , G. , Léonil , J. , Mills , C.E.N. and Mackie , A. R. 2010 . Food processing increases casein resistance to simulated infant digestion . Mol. Nutr. Food. Res. , 54 ( 11 ) : 677 – 1689 .
  • Elashoff , J. D. , Reedy , T. J. and Meyer , J. H. 1982 . Analysis of gastric emptying data . Gastroenterology , 83 : 1306 – 1312 .
  • Engberg , S. , Mansson , M. , Andersson , Y. , Jakobsson , I. and Lindberg , T. 1999 . Trypsin and elastase activity in duodenal juice from preterm infants before and after a test meal of human milk . Prenat. Neonat. Med. , 4 : 466 – 471 .
  • Ewer , A. K. , Durbin , G. M. , Morgan , M. E. I. and Booth , I. W. 1994 . Gastric emptying in preterm infants . Arch. Dis. Child. , 71 : F24 – F27 .
  • Ewer , A. K. , Morgan , M. E. I. and Booth , I. W. 1996 . Gastric emptying and gastro-oesophageal reflux in preterm infants . Arch. Dis. Child , 75 : F117 – F121 .
  • Faure , C. and Navarro , J. 2000 . “ Chapter 8. Maturation de la motricité digestive ” . In Gastro-Entérologie Pédiatrique , 97 – 109 . Paris : Flammarion .
  • Foltz , M. , Maljaars , J. , Schuring , E. A. H. , Van Der Wal , R. J. P. , Boer , T. , Duchateau , G. S. M. , Peters , H. P. F. , Stellaard , F. and Masclee , A. A. 2009 . Intragastric layering of lipids delays lipid absorption and increases plasma CCK but has minor effects on gastric emptying and appetite . Am. J. Physiol-Gastr. L. , 296 ( 5 ) : G982 – G991 .
  • Forsyth , J. S. , Ross , P. E. and Bouchier , I. A. D. 1983 . Bile salts in breast milk . Eur. J. Pediatr. , 140 ( 2 ) : 126 – 127 .
  • Fredrikzon , B. and Hernell , O. 1977 . Role of feeding on lipase activity in gastric contents . Acta Paediatr , 66 ( 4 ) : 479 – 484 .
  • Fredrikzon , B. and Olivecrona , T. 1978 . Decrease of lipase and esterase activities in intestinal contents of newborn infants during test meals . Pediatr. Res. , 12 ( 5 ) : 631 – 634 .
  • Freeman , H. J. and Kim , Y. S. 1978 . Digestion and absorption of protein . Annu. Rev. Med. , 29 ( 1 ) : 99 – 116 .
  • Garzi , A. , Messina , M. , Frati , F. , Carfagna , L. , Zagordo , L. , Belcastro , M. , Parmiani , S. , Sensi , L. and Marcucci , F. 2002 . An extensively hydrolysed cow's milk formula improves clinical symptoms of gastroesophageal reflux and reduced the gastric emptying time in infants . Allergol. Immunopathol. , 30 ( 1 ) : 36 – 41 .
  • Gaskin , K. J. , Durie , P. R. , Lee , L. and Forstner , G. G. 1984 . Colipase and lipase secretion in childhood-onset pancreatic insufficiency: Delineation of patients with steatorrhea secondary to relative colipase deficiency . Gastroenterology , 86 ( 1 ) : 1 – 7 .
  • Geigy , J. R. 1973 . “ Gastric juice ” . In Scientific Tables , Edited by: Geigy , J. R. 123 – 133 . Basel : Documenta Geigy .
  • Gellis , S. S. , White , P. and Pfeffer , W. 1949 . Gastric suction; a proposed additional technic for the prevention of asphyxia in infants delivered by cesarean section; a preliminary report . New Engl. J. Med. , 240 ( 14 ) : 533 – 537 .
  • Giller , T. , Buchwald , P. , Blum-Kaelin , D. and Hunziker , W. 1992 . Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity . J. Biol. Chem. , 267 : 16509 – 16516 .
  • Golding , M. and Wooster , T. J. 2010 . The influence of emulsion structure and stability on lipid digestion . Curr. Opin. Colloid Int. , 15 ( 1–2 ) : 90 – 101 .
  • Halpern , Z. , Vinograd , Z. , Laufer , H. , Gilat , T. , Moskowitz , M. and Bujanover , Y. 1996 . Characteristics of gallbladder bile of infants and children . J. Pediatr. Gastroenterol. Nutr. , 23 ( 2 ) : 147 – 50 .
  • Hamosh , M. 1983 . Lingual lipase and fat digestion in the neonatal period . J. Pediatr. Gastroenterol. Nutr. , 2 : S236 – S241 .
  • Hamosh , M. 1996 . Digestion in the newborn . Clin Perinatol. , 23 : 191 – 209 . Jun;(2)
  • Hamosh , M. , Scanlon , J. W. , Ganot , D. , Likel , M. , Scanlon , K. B. and Hamosh , P. 1981 . Fat digestion in the newborn. Characterization of lipase in gastric aspirates of premature and term infants . J. Clin. Invest. , 67 ( 3 ) : 838 – 846 .
  • Hamosh , M. , Sivasubramanian , K. N. , Salzman-Mann , C. and Hamosh , P. 1978 . Fat digestion in the stomach of premature infants. I. Characteristics of lipase activity . J. Pediatr. , 93 ( 4 ) : 674 – 679 .
  • Harries , J. T. and Fraser , A. F. 1968 . The acidity of the gastric contents of premature babies during the first fourteen days of life . Biol. Neonate. , 12 ( 3 ) : 186 – 193 .
  • Henderson , T. R. , Hamosh , M. , Armand , M. , Mehta , N. R. and Hamosh , P. 1998 . Gastric proteolysis in the preterm infant: Protein digestion is limited and is not affected by diet, human milk or formula + 580 . Pediatr. Res. , 43 ( 4 ) : 101
  • Henderson , T. R. , Hamosh , M. , Armand , M. , Mehta , N. R. and Hamosh , P. 2001 . “ Chapter 43. Gastric Proteolysis in Preterm Infants fed mother's milk or formula ” . In Bioactive Components in Human Milk , Edited by: Newburg , D. S. 403 – 408 . New-York : Kluwer Academic/Plenum Publishers .
  • Hernell , O. and Blackberg , L. 1994 . Human milk bile salt-stimulated lipase: Functional and molecular aspects . J. Pediatr. , 125 ( 5 ) : S56 – S61 .
  • Hernell , O. , Blackberg , L. , Chen , Q. , Sternby , B. and Nilsson , A. 1993 . Does the bile salt-stimulated lipase of human milk have a role in the use of the milk long-chain polyunsaturated fatty acids . J. Pediatr. Gastr. Nutr. , 16 ( 4 ) : 426 – 431 .
  • Howles , P. N. , Stemmerman , G. N. , Fenoglio-Preiser , C. M. and Huy , D. Y. 1999 . Cholesterol ester lipase activity in milk prevents fat-derived intestinal injury in neonatal mice . Am. J. Physiol. Gastr. L. , 40 ( 3 ) : G653 – G661 .
  • Hui , D. Y. and Howles , P. N. 2002 . Carboxyl ester lipase . J. Lipid Res. , 43 ( 12 ) : 2017 – 2030 .
  • Humphrey , S. P. and Williamson , R. T. 2001 . A review of saliva: Normal composition, flow, and function . J. Prosth. Dent. , 85 ( 2 ) : 162 – 169 .
  • Hunt , J. N. and Knox , M. T. 1968 . A relation between the chain length of fatty acids and the slowing of gastric emtying . J. Physiol. , 194 ( 2 ) : 327 – 336 .
  • Hur , S. J. , Lim , B. O. , Decker , E. A. and McClements , D. J. 2011 . In vitro digestion models for food applications . Food Chem , 125 : 1 – 12 .
  • Hyde , G. A. 1968 . Gastric secretions following neonatal surgery . J. Pediatr. Surg. , 3 ( 6 ) : 691 – 695 .
  • Jenness , R. 1979 . The composition of human milk . Semin. Perinatol. , 3 ( 3 ) : 225 – 239 .
  • Kalantzi , L. , Goumas , K. , Kalioras , V. , Abrahamsson , B. , Dressman , J. B. and Reppas , C. 2006 . Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies . Pharm. Res. , 23 ( 1 ) : 165 – 175 .
  • Kauffman , R. E. 2011 . “ Chapter 3. Drug action and therapy in the infant and child ” . In Neonatal and Pediatric Pharmacology: Therapeutic Principles in Practice , Edited by: Summer , Y. J. and Aranda , J. V. 20 – 30 . Philadelphia : Lippincott Williams and Wilkins .
  • Keene , M. L. F. and Hewer , E. E. 1929 . Digestive enzymes of the human foetus . Lancet , 1 : 767 – 769 .
  • Kelly , D. and Coutts , A. G. P. 2000 . Development of digestive and immunological function in neonates: Role of early nutrition . Livest. Prod. Sci. , 66 ( 2 ) : 161 – 167 .
  • Kelly , D. G. , Sternby , B. and DiMagno , E. P. 1991 . How to protect human pancratic enzyme activities in frozen duodenal juice . Gastroenterology , 100 ( 1 ) : 189 – 195 .
  • Kelly , E. J. and Newell , S. J. 1994 . Gastric ontogeny: Clinical implications . Arch. Dis. Child. Fetal and Neonat. Ed. , 71 ( 2 ) : F136 – F141 .
  • Layer , P. , Go , V. L. W. and DiMagno , E. P. 1986 . Fate of pancreatic enzymes during small intestinal aboral transit in humans . Am. J. Physiol. , 251 ( 4 ) : G475 – G480 .
  • Lebenthal , E. and Lee , P. C. 1980 . Development of functional response in human exocrine pancreas . Pediatr , 66 ( 4 ) : 556 – 560 .
  • Lengsfeld , H. , Beaumier-Gallon , G. , Chahinian , H. , De Caro , A. , Verger , R. , Laugier , R. and Carrière , F. 2003 . “ Physiology of gastrointestinal lipolysis and therapeutical use of lipase and digestive lipase inhibitors ” . In Lipases and Phospholipases in Drug Development , Edited by: Muller , G. and Petry , S. 195 – 229 . Weihem : Wiley-CH .
  • Lehtonen , L. , Svedström , E. , Kero , P. and Korvenranta , H. 1993 . Gall bladder contractility in preterm infants . Arch Dis Child. , 68 ( 1 ) : 43 – 45 .
  • Lehtonen , L. , Svedström , E. and Korvenranta , H. 1992 . The size and contractility of the gallbladder in infants . Pediatr. Radiol. , 22 : 515 – 518 .
  • Li , X. , Lindquist , S. , Lowe , M. , Noppa , L. and Hernell , O. 2007 . Bile salt-stimulated lipase and pancreatic lipase-related protein 2 are the dominating lipases in neonatal fat digestion in mice and rats . Pediatr. Res. , 62 ( 5 ) : 537 – 541 .
  • Liddle , R. A. , Morita , E. T. , Conrad , C. K. and Williams , J. A. 1986 . Regulation of gastric emptying in humans by cholecystokinin . J. Clin. Invest. , 77 ( 3 ) : 992 – 996 .
  • Lindquist , S. and Hernell , O. 2010 . Lipid digestion and absorption in early life: An update . Curr. Opin. Clin. Nutr. Metab. Care. , 13 ( 3 ) : 314 – 320 .
  • Lowe , M. E. 2002 . The triglyceride lipases of the pancreas . J. Lipid Res. , 43 ( 12 ) : 2007 – 2016 .
  • Lowe , M. E. , Rosenblum , J. and Strauss , A. 1989 . Cloning and characterization of human pancreatic lipase cDNA . J. Biol. Chem. , 264 : 20042 – 20048 .
  • Maldonado-Valderrama , J. , Wilde , P. , Macierzanka , A. and Mackie , A. 2011 . The role of bile salts in digestion . Adv. Colloid Interfac. , 165 ( 1 ) : 36 – 46 .
  • Manson , W. G. and Weaver , L. T. 1997 . Fat digestion in the neonate . Arch. Dis. Child. , 76 : F206 – F211 .
  • Marciani , L. , Faulks , R. , Wicham , M. , Bush , D. , Pick , B. , Wright , J. , Cox , E. , Fillery-travis , A. , Gowland , P. A. and Spiller , R. 2009 . Effect of intragastric acid stability of fat emulsions on gastric emptying, plasma lipid profile and postprandial satiety . British J. Nutr. , 101 ( 6 ) : 918 – 928 .
  • Marino , L. R. , Bacon , B. R. , Hines , J. D. and Halpin , T. C. 1984 . Parietal cell function of full-term and premature infants: Unstimulated gastric acid and intrinsic factor secretion . J. Pediatr. Gastroenterol. Nutr. , 3 ( 1 ) : 23 – 27 .
  • Martin , C. , Edwards , C. and Weaver , L. T. 1999 . Starch digestion in infancy . J. Pediatr. Gastroenterol. Nutr. , 29 ( 2 ) : 116 – 124 .
  • Mas , E. , Abouakil , N. , Roudani , S. , Miralles , F. , Guy-Crotte , O. , Figarella , C. , Escribano , M. J. and Lombardo , D. 1993 . Human fetoacinar pancreatic protein: An oncofetal glycoform of the normally secreted pancreatic bile-salt-dependent lipase . Biochem. J. , 289 : 609 – 615 .
  • Mason , S. 1962 . Some aspects of gastric function in the newborn . Arch. Dis. Child. , 37 : 387 – 391 .
  • McClure , R. J. and Newell , S. J. 1996 . Effect of fortifying breast milk on gastric emptying . Arch. Dis. Child. , 74 : F60 – F62 .
  • McClean , P. and Weaver , L. T. 1993 . Ontogeny of human pancreatic exocrine function . Arch. Dis. Child. , 68 : 62 – 65 .
  • McClements , D. J. and Li , Y. 2009 . Controlling lipid bioavailability through physicochemical and structural approaches . Crit. Rev. Food Sci. , 49 ( 1 ) : 48 – 67 .
  • McClements , D. J. and Li , Y. 2010 . Review of in vitro digestion models for rapid screening of emulsion-based systems . Food Funct. , 1 ( 1 ) : 32 – 59 .
  • McConnell , E. , Fadda , H. M. and Basit , A. W. 2008 . Gut instincts: Explorations in intestinal physiology and drug delivery . International J. Pharm. , 364 : 213 – 226 .
  • Ménard , D. , Monfils , S. and Tremblay , E. 1995 . Ontogeny of human gastric lipase and pepsin activities . Gastroenterology , 108 : 1650 – 1656 .
  • Miclat , N. N. , Hodgkinson , R. and Marx , G. F. 1978 . Neonatal gastric pH . Anesthesia & Analgesia. , 57 ( 1 ) : 98 – 101 .
  • Mitchell , D. J. , McClure , B. G. and Tubman , T. R. J. 2001 . Simultaneous monitoring of gastric and oesophageal pH reveals limitations of conventional oesophageal pH monitoring in milk fed infants . Arch. Dis. Child. , 84 : 273 – 276 .
  • Moran , T. H. and Kimberly , P. K. 2004 . Gastrointestinal satiety signals. II. Cholecystokinin . Am. J. Physiol. Gastrointest. Liver Physiol. , 286 : G183 – G188 .
  • Mu , H. and Hoy , C. E. 2004 . The digestion of dietary triacylglycerols . Prog. Lipid Res. , 43 : 105 – 133 .
  • Murray , R. D. , Kerzner , B. , Sloan , H. R. , McClung , H. J. , Gilbert , M. and Ailabouni , A. 1986 . The contribution of salivary amylase to glucose polymer hydrolysis in premature infants . Pediatr. Res. , 20 ( 2 ) : 186 – 191 .
  • Neu , J. 2007 . Gastrointestinal maturation and implications for infant feeding . Early Hum. Dev. , 83 ( 12 ) : 767 – 775 .
  • Newell , S. J. , Chapman , S. and Booth , I. W. 1993 . Ultrasonic assessment of gastric emptying in the preterm infant . Arch. Dis. Child. , 69 : 32 – 36 .
  • Norman , A. , Strandvik , B. and Ojamae , O. 1972 . Bile acids and pancreatic enzymes during absorption in the newborn . Acta Paediatr. Scand. , 61 ( 5 ) : 571 – 576 .
  • Nouri-Sorkhabi , M. H. , Chapman , B. E. , Kuchel , P. W. , Gruca , A. M. and Gaskin , K. J. 2000 . Parallel secretion of pancreatic phospholipase A2, phospholipase A1, lipase, and colipase in children with exocrine pancreatic dysfunction . Pediatr. Res. , 48 ( 6 ) : 735 – 740 .
  • O’Keefe , S. J. D. , Lee , R. B. , Li , J. , Stevens , S. , bou-Assi , S. and Zhou , W. 2005 . Trypsin secretion and turnover in patients with acute pancreatitis . Am. J. Physiol Gastr. L. , 289 ( 2 ) : G181 – G187 .
  • Omari , T. I. and Davidson , G. P. 2003 . Multipoint measurement of intragastric pH in healthy preterm infants . Arch. Dis. Child. Fetal and Neonat Ed. , 88 ( 6 ) : F517 – F520 .
  • Oomen , A. G. , Rompelberg , C. J. M. , Bruil , M. A. , Dobbe , C. J. G. , Pereboom , D. P. K. and Sips , A. 2003 . Development of an in vitro digestion model for estimating the bioaccessibility of soil contaminants . Arch. Environ. Con. Tox. , 44 : 281 – 287 .
  • Pafumi , Y. , Lairon , D. , Lechene , P. , Juhel , C. , Storch , J. , Hamosh , M. and Armand , M. 2002 . Mechanisms of inhibition of triacylglycerol hydrolysis by human gastric lipase . J. Biol. Chem. , 277 ( 31 ) : 28070 – 28079 .
  • Roman , C. , Carrière , F. , Villeneuve , P. , Pina , M. , Millet , V. , Simeoni , U. and Sarles , J. 2007 . Quantitative and qualitative study of gastric lipolysis in premature infants: Do MCT-enriched infant formulas improve fat digestion? . Pediatr. Res. , 61 ( 1 ) : 83 – 88 .
  • Roudani , S. , Miralles , F. , Margotat , A. , Escribano , M.-J. and Lombardo , D. 1995 . Bile salt-dependent lipase transcripts in human fetal tissues . Biochim. Biophys. Acta. , 1264 ( 1 ) : 141 – 150 .
  • Roy , C. C. , Weber , A. M. , Lepage , G. , Smith , L. and Levy , E. 1988 . Digestive and absorptive phase anomalies associated with the exocrine pancreatic insufficiency of cystic fibrosis . J. Pediatr. Gastroenterol. Nutr. , 7 : S1 – S7 .
  • Roy , R. N. , Pollinitz , R. P. , Hamilton , J. R. and Chance , G. W. 1977 . Impaired assimilation of nasojejunal feeds in healthy low-birth weight newborn infants . J. Pediatr. , 90 ( 3 ) : 431 – 434 .
  • Rubio , S. , Lacaze-Masmonteil , T. , Bourbon , J. and Ducroc , R. 1995 . Les surfactants dans le tube digestif . Archives de Pédiatrie , 2 ( 1 ) : 79 – 84 .
  • Rudloff , S. and Lonnerdal , B. 1992 . Solubility and digestibility of milk proteins in infant formulas exposed to different heat treatments . J. Pediatr. Gastroenterol. Nutr. , 15 ( 1 ) : 25 – 33 .
  • Sakai , K. , Yoshino , K. , Satter , M. A. , Ota , F. , Nil , Y. , Fukuta , K. , Ueda , N. , Shimizu , Y. and Yamamoto , S. 2000 . Effects of pH variation and NaCl on in vitro digestibility of cow's milk proteins in commercially available infant formulas . J. Nutr. Sci. Vitaminol. , 46 ( 6 ) : 325 – 328 .
  • Saliba , E. , Hamamah , S. , Gold , F. and Benhamed , M. 2001 . “ Développement anatomique ” . In Médecine et biologie du développement. Du gène au nouveau-né , 293 – 305 . Paris : Masson .
  • Savary , P. 1971 . The action of pure pig pancreatic lipase upon esters of long chain fatty acids and short chain primary alcohols . Biochim. Biophys. Acta. , 248 ( 2 ) : 149 – 155 .
  • Sbarra , V. , Mas , E. , Henderson , T. R. , Hamosh , M. , Lombardo , D. and Hamosh , P. 1996 . Digestive lipases of the newborn ferret: Compensatory role of milk bile salt-dependent lipase . Pediatr. Res. , 40 ( 2 ) : 263 – 268 .
  • Scanff , P. , Yvon , M. , Pelissier , J. P. , Guilloteau , P. and Toullec , R. 1992 . Effect of some technological treatments of milk on in vivo gastric emptying of immunoreactive whey proteins . Le Lait , 72 ( 1 ) : 43 – 51 .
  • Schanler , R. J. , Goldblum , R.M , Garza , C. and Goldman , A. S. 1986 . Enhanced fecal excretion of selected immune factors in very low birth weight infants fed fortified human milk . Pediatr. Res. , 20 : 711 – 715 .
  • Schipper , R. G. , Silletti , E. and Vingerhoeds , M. H. 2007 . Saliva as research material: Biochemical, physicochemical and practical aspects . Arch. Oral Biol. , 52 ( 12 ) : 1114 – 1135 .
  • Schlamowitz , M. and Petersen , L. V. 1959 . Studies on the optimum pH for the action of pepsin on ‘native’ and denaturated bovin serum albumin and bovine hemoglobin . J. Biol. Chem. , 234 ( 12 ) : 3137 – 3145 .
  • Seidel , B. M. , Schubert , S. , Schulze , B. and Borte , M. 2001 . Secretory IgA, free secretory component and IgD in saliva of newborn infants . Early Hum. Dev. , 62 ( 2 ) : 159 – 164 .
  • Setchell , K. D. , Dumaswala , R. , Colombo , C. and Ronchi , M. 1988 . Hepatic bile acid metabolism during early development revealed from the analysis of human fetal gallbladder bile . J. Biol. Chem. , 263 ( 32 ) : 16637 – 16644 .
  • Sevenhuysen , G. P. , Holodinsky , C. and Dawes , C. 1990 . Development of salivary alpha-amylase in infants from birth to 5 months . Am. J. Clin. Nutr. , 39 ( 4 ) : 584 – 588 .
  • Shub , M. D. , Pang , K. Y. , Swann , D. A. and Walker , W. A. 1983 . Age-related changes in chemical composition and physical properties of mucus glycoproteins from rat small intestine . Biochem. J. , 215 : 405 – 411 .
  • Sias , B. , Ferrato , F. , Grandval , P. , Boulanger , P. , De Caro , A. , Leboeuf , B. , Verger , R. and Carrière , F. 2004 . Human pancreatic lipase-related 2 is a galactolipase . Biochem. , 43 ( 31 ) : 10138 – 10148 .
  • Siegel , M. , Krantz , B. and Lebenthal , E. 1985 . Effect of fat and carbohydrate composition on the gastric emptying of isocaloric feeding in premature infants . Gastroenterology , 89 ( 4 ) : 785 – 790 .
  • Siegel , M. , Lebenthal , E. and Krantz , B. S. B. 1984 . Effect of caloric density on gastric emptying in premature infants . J. Pediatr. , 104 ( 1 ) : 118 – 122 .
  • Siegel , M. , Lebenthal , E. , Topper , W. , Krantz , B. and Li , P. K. 1982 . Gastric emptying in prematures of isocaloric feedings with differing osmolalities . Pediatr. Res. , 16 ( 2 ) : 141 – 147 .
  • Signer , E. and Fridrich , R. 1975 . Gastric emptying in newborns and young infants . Acta Paediatr. Scand. , 64 ( 3 ) : 525 – 530 .
  • Signer , E. , Murphy , G. M. , Edkins , S. and Anderson , C. M. 1974 . Role of bile salts in fat malabsorption of premature infants . Arch. Dis. Child. , 49 ( 3 ) : 174 – 180 .
  • Singh , M. , Monterio , C. and Ghai , O. P. 1970 . Gastric juice pH and blood glucose in the newborn . Indian J. Pediatr. , 37 ( 1 ) : 1 – 3 .
  • Singh , H. , Ye , A. and Horne , D. 2009 . Structuring food emulsions in the gastrointestinal tract to modify lipid digestion . Prog. Lipid Res. , 48 ( 2 ) : 92 – 100 .
  • Smith , L. J. , Kaminsky , S. and D'souza , S. W. 1986 . Neonatal fat digestion and lingual lipase . Acta Paediatr , 75 ( 6 ) : 913 – 918 .
  • Staelens , S. , Van Den Driessche , M. , Barclay , D. , Carrié-Faessler , A. L. , Haschke , F. , Verbeke , K. , Vandebroek , H. , Allegaert , K. , Van Overmeire , B. , Van Damme , M. and Veereman-Wauters , G. 2008 . Gastric emptying in healthy newborns fed an intact protein formula, a partially and an extensively hydrolysed formula . Clin. Nutr. , 27 ( 2 ) : 264 – 268 .
  • Sternby , B. , Nilsson , A. , Melin , T. and Borgström , B. 1991 . Pancreatic lipolytic enzymes in human duodenal contents . Scand. J. Gastroenterol. , 26 : 859 – 866 .
  • Stromqvist , M. , Tornell , J. , Edlund , M. , Edlund , A. , Johansson , T. , Lindgren , K. , Lundberg , L. and Hansson , L. 1996 . Recombinant human bile salt-stimulated lipase: An example of defective O-glycosylation of a protein produced in milk of transgenic mice . Transgenic Res , 5 ( 6 ) : 475 – 485 .
  • Thompson , J. 1951 . The volume and gastric contents in the unfed newborn infant . Arch. Dis. Child. , 26 : 558 – 565 .
  • Tribl , B. , Sibbald , W. J. , Vogelsang , H. , Spitzauer , S. , Gangl , A. and Madl , C. 2003 . Exocrine pancreatic dysfunction in sepsis . Eur. J. Clin. Inv. , 33 ( 3 ) : 239 – 243 .
  • Driessche , M. , Peeters , K. , Marien , P. , Ghoos , Y. , Devlieger , H. and Veereman-Wauters , G. 1999 . Gastric emptying in formula-fed and breast-fed infants measured with the 13C-octanoic acid breath test . J. Pediatr. Gastroenterol. Nutr. , 29 ( 1 ) : 46 – 51 . Van Den
  • Tilbeurgh , H. , Sarda , L. , Verger , R. and Cambillau , C. 1992 . Structure of the pancreatic lipase-procolipase complex . Nature. , 359 : 159 – 162 .
  • Ville , E. , Carrière , F. , Renou , C. and Laugier , R. 2002 . Physiological study of pH stability and sensitivity to pepsin of human gastric lipase . Digestion , 65 ( 2 ) : 73 – 81 .
  • Wang , C. S. , Martindale , M. E. , King , M. M. and Tang , J. 1989 . Bile-salt-activated lipase: Effect on kitten growth rate . Am. J. Clin.Nutr. , 49 ( 3 ) : 457 – 463 .
  • Watkins , J. B. , Ingall , D. , Szczepanik , P. , Klein , P. D. and Lester , R. 1973 . Bile-salt metabolism in the newborn . New England J. Medicine. , 288 ( 9 ) : 431 – 434 .
  • Weisselberg , B. , Yahav , J. , Reichman , B. and Jonas , A. 1992 . Basal and meal-stimulated pepsinogen secretion in preterm infants: A longitudinal study . J. Pediatr. Gastroenterol. Nutr. , 15 ( 1 ) : 58 – 62 .
  • Whitcomb , D. C. and Lowe , M. E. 2007 . Human pancreatic digestive enzymes . Digestive Dis. Sci. , 52 : 1 – 17 .
  • Wickham , M. , Faulks , R. and Mills , C. 2009 . In vitro digestion methods for assessing the effect of food structure on allergen breakdown . Mol. Nutr. Food Res. , 53 : 952 – 958 .
  • Winkler , F. , D’Arcy , A. and Hunziker , W. 1990 . Structure of human pancreatic lipase . Nature , 343 : 771 – 774 .
  • Wolman , I. J. 1946 . Gastric phase of milk digestion in childhood: A study of the fasting secretions and of the physiologic responses to “hard curd” (pasteurized) and “soft curd” (homogenized) milks . Am. J. Dis. Child. , 71 ( 4 ) : 394 – 422 .
  • Yahav , J. , Carrion , V. , Lee , P. C. and Lebenthal , E. 1987 . Meal-stimulated pepsinogen secretion in premature infants . J. Pediatr. , 110 : 949 – 951 .
  • Yang , L.-Y. , Kuksis , A. and Myher , J. J. 1990 . Lipolysis of menhaden oil triacylglycerols and the corresponding fatty acid alkyl esters by pancreatic lipase in vitro: A reexamination . J. Lipid Res. , 31 : 137 – 148 .
  • Yang , Y. , Sanchez , D. , Figarella , C. and Lowe , M. E. 2000 . Discoordinate expression of pancreatic lipase and two related proteins in the human fetal pancreas . Pediatr. Res. , 47 : 184 – 188 .
  • Yoo , J. Y. and Chen , X. D. 2006 . GIT physicochemical modeling—A critical review . Int. J. Food Eng. , 2 ( 4 ) : 1 – 7 .
  • Zoppi , G. , Andreotti , G. , Pajno-Ferrara , F. , Bellini , P. and Gaburro , D. 1973 . The development of specific responses of the exocrine pancreas to pancreozymin and secretin stimulation in newborn infants . Pediatr. Res. , 7 ( 4 ) : 198 – 203 .
  • Zoppi , G. , Andreotti , G. , Pajno-Ferrara , F. , Njai , D. M. and Gaburro , D. 1972 . Exocrine pancreas function in premature and full term neonates . Pediatr. Res. , 6 ( 12 ) : 880 – 886 .

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