A Question Mark on Iron Deficiency in 185 Million People of Pakistan: Its Outcomes and Prevention

REFERENCES

• Abbassi , R. M. , Ansari , S. , Devrajani , B. R. and Abbasi , S. 2009 . The prevalence and risk factors of anemia in pregnanat women . Med. Channel , 15 : 70 – 73 .
   Google Scholar
• Abu-Saad , K. and Fraser , D. 2010 . Maternal nutrition and birth outcomes . Epidemiol. Rev , 32 : 5 – 25 .
   PubMed Web of Science ®Google Scholar
• Agarwal , K. N. , Gomber , S. , Bisht , H. and Som , M. 2003 . Anemia prophylaxis in adolescent school girls by weekly or daily iron-folate supplementation . Indian Pediatr , 40 : 296 – 301 .
   PubMedGoogle Scholar
• Agha , F. , Agha , S. , Khan , R. A. and Ghafoor , A. 1992 . Iron deficiency in adolescents . J. Pak. Med. Ass , 42 : 3 – 5 .
   PubMedGoogle Scholar
• Ahmed , M. and Farooq , U. 2010 . “ The state of food security in Pakistan: Future challenges and coping strategies ” . In Pak. Develop. Rev. Vol. 49 , 903 – 923 .
   Google Scholar
• Akhtar , P. , Muhammad , D. , Orfi , S. D. , Ahmad , N. and Rehamn , K. 2005 . Assessment of daily iron intake for the Pakistani population . Nutr. Food Sci , 35 : 109 – 117 .
   Google Scholar
• Ali , A. , Fathy , G. A. , Fathy , H. A. and El-Ghaffar , N. A. 2011 . Epidemiology of iron deficiency anemia: Effect of physical growth in primary school children the importance of hookworms . Int. J. Acad Res , 3 : 495 – 500 .
   Google Scholar
• Allen , L. H. , De-Benoist , B. , Dary , O. and Hurrel , R. 2006 . Guidelines on Food Fortification with Micronutrients , Geneva , , Switzerland : WHO/FAO .
   Google Scholar
• Anjum , F. M. , Zulfiqar , A. , Asghar , A. and Hussain , S. 2006 . Use of iron as fortificant in whole-wheat flour and in leavened flat breads in developing countries (a review) . Electron. J. Environ. Agric. Food Chem , 5 : 1366 – 1370 .
   Google Scholar
• Annibale , B. , Severi , C. , Chistolini , A. , Antonelli , G. , Lahner , E. , Marcheggiano , A. , Iannoni , C. , Monarca , B. and Delle Fave , G. 2001 . Efficacy of gluten-free diet alone on recovery from iron deficiency anemia in adult celiac patients . Am. J. Gastroenterol , 96 : 132 – 137 .
   PubMed Web of Science ®Google Scholar
• Ansari , B. N. , Baddrudin , S. H. , Karmalian , R. , Harris , H. , Jehan , I. , Pasha , O. , Moss , N. , McClure , E. M. and Goldenberg , R. L. 2008 . Anemia prevalence and risk factors in pregnant women in an urban area of Pakistan . Food Nutr. Bull , 29 : 132 – 139 .
   PubMed Web of Science ®Google Scholar
• Asif , N. , Hassan , K. , Mahmid , S. , Zaheer , H. A. , Naseem , L. , Zafar , T. and Shams , R. 2007 . Comparison of serum ferritin levels. I: Three trimesters of pregnancy and their correlation with increasing gravidity . Int. J. Pathol , 5 : 26 – 30 .
   Google Scholar
• Awan , J. A. , Siddique , M. I. and Gillani , A. H. 1995 . Fortification of wheat flour . Pak. J. Food Sci , 6 : 39 – 49 .
   Google Scholar
• Awan , M. M. , Akbar , M. A. and Khan , M. I. 2004 . A study of anemia in pregnant women of railway colony, Multan . Pak. J. Med. Sci , 43 : 11 – 14 .
   Google Scholar
• Bakhatwar , U. K. , Khan , Y. and Nasar , R. 2007 . Relationship between maternal hemoglobin and perinatal outcomes . Rawal. Med. J , 32 : 102 – 104 .
   Google Scholar
• Balarajan , Y. , Ramankrishnan , U. , Özaltin , E. , Shankar , A. H. and Subramanian , S. V. 2011 . Anaemia in low-income and middle-income countries . Lancent , Corrected Proof
   Google Scholar
• Batra , J. and Seth , P. K. 2002 . Effect of iron deficiency on developing rat brain . Indian J. Clin. Biochem , 17 : 108 – 114 .
   Google Scholar
• Bayoumeu , F. , Subiran-Buisset , C. , Baka , N. E. , Legagneur , H. , Monnicer-Barbarino , P. and Lexenaire , M. C. 2002 . Iron therapy in iron defiecny anemia in pregnancy intravenous route versus oral route . Am. J. Obstet. Gyneocol , 186 : 518 – 540 .
   PubMed Web of Science ®Google Scholar
• Beard , J. L. 2000a . Effectiveness and strategies of iron supplementation during pregnancy . Am. J. Clin. Nutr , 71 : 1288S – 1294S .
   PubMed Web of Science ®Google Scholar
• Beard , J. L. 2000b . Iron requirements in adolescent females . J. Nutr , 130 : 440S – 442S .
   PubMed Web of Science ®Google Scholar
• Beard , J. L. , Hendricks , M. K. , Perez , E. M. , Murray-Kolb , L. E. , Berg , A. , Vernon-Feagans , L. , Irlam , J. , Isaacs , W. , Sive , A. and Tomlinson , M. 2005 . Maternal iron deficiency anemia affects postpartum emotions and cognition . J. Nutr. , 135 : 267 – 272 .
   PubMed Web of Science ®Google Scholar
• Bellamy , C. 2000 . The Time to Sow, League Table: Stunting in Children Under Age 5, the Progress of Nations , 14 – 15 . New York : UNICEF .
   Google Scholar
• Benoist , B. 2008 . Conclusions of a WHO technical consultation on folate and vitamin B12 deficiencies . Food Nutr. Bull , 29 ( suppl 2 ) : S238 – S244 .
   PubMed Web of Science ®Google Scholar
• Berglund , S. , Westrup , B. and Demeltof , M. 2010 . Iron supplemnts reduce the risk of iron deficiency anemia in marginally low birth weight infants . Pedriatics , 126 : 874 – 883 .
   PubMed Web of Science ®Google Scholar
• Bergman , M. , Bessler , H. , Salman , H. , Siomin , D. , Straussberg , R. and Djaldetti , M. 2004 . In vitro cytokine production in patients with iron deficiency anemia . Clin. Immunol. , 113 : 340 – 344 .
   PubMed Web of Science ®Google Scholar
• Beutler , E. and Waalen , J. 2006 . The definition of anemia: What is the lower limit of normal of the blood hemoglobin concentration? . Blood , 107 : 1747 – 1750 .
   PubMed Web of Science ®Google Scholar
• Bhutta , Z. A. 2000 . Iron and Zinc intake from complementary foods: Some issues from Pakistan . Pediatrics , 106 : 1295 – 1297 .
   PubMed Web of Science ®Google Scholar
• Black , R. E. , Allen , H. , Bhutta , Z. A. , Caulfield , L. E. , de Onis , M. and Ezzati , M. 2008a . Maternal and child under nutrition, global and regional exposures and health consequences, maternal and child under nutrition . Lancet , 371 : 243 – 260 .
   PubMed Web of Science ®Google Scholar
• Black , R. E. , Allen , L. A. , Bhutta , Z. A. , Claudified , L. E. , Onis , M. D. , Ezzati , Mathers , C. and Rivera , J. 2008b . Maternal and child undernutrition global and regional exposures andhealth consequences . Lancet , 371 : 243 – 260 .
   PubMed Web of Science ®Google Scholar
• Bowlus , C. L. 2003 . The role of iron in T cell development and autoimmunity . Autoimmun Rev , 2 : 73 – 78 .
   PubMed Web of Science ®Google Scholar
• Boy , E. , Mannar , V. , Pandav , C. , de Benoist , B. , Viteri , F. , Fontaine , O. and Hotz , C. 2009 . Achievements, challenges, and promising new approaches in vitamin and mineral deficiency control . Nutr. Rev , 67 : S24 – S30 .
   PubMed Web of Science ®Google Scholar
• Codex Alimentarius Commision . 2001 . Codex Alimentarius Commision Procedural Manual , Rome : Food and Agriculture Organization .
   Google Scholar
• Cook , J. D. , Flowers , C. H. and Skikne , B. S. 2003 . The quantitative assessment of body iron . Blood , 101 : 3359 – 3364 .
   PubMed Web of Science ®Google Scholar
• Cook , J. D. and Reusser , M. E. 1983 . Iron fortification an update . Am. J. Clin. Nutr , 38 : 648 – 659 .
   PubMed Web of Science ®Google Scholar
• Crofton , R. W. , Gvozdanovic , D. , Gvozdanovic , S. , Khin , C. C. , Brunt , P. W. , Mowat , N. A. and Aggett , P. J. 1989 . Inorganic zinc and the absorption of ferrous iron . Am. J. Clin. Nutr. , 50 : 141 – 144 .
   PubMed Web of Science ®Google Scholar
• Dallman , P. , Barr , G. , Allen , C. and Shinefield , H. 1978 . Hemoglobin concentration in white, black, and oriental children: Is there a need for separate criteria in screening for anemia? . Am. J. Clin. Nutr. , 31 : 377 – 380 .
   PubMed Web of Science ®Google Scholar
• Davidson , L. 1996 . “ Iron bioavailability from weaning food: effect of phytic acid ” . In Micronutrients Interactions Impact on child. Washington, DC , , USA
   Google Scholar
• Davila-Hicks , P. , Theil , E. C. and Lonnerdal , B. 2004 . Iron in ferritin or in salts (ferrous sulfate) is equally bioavailable in nonanemic women . Am. J. Clin. Nutr. , 80 : 936 – 940 .
   PubMed Web of Science ®Google Scholar
• De-Souza , A. I. , Batista , F. M. , Ferreira , L. O. and Figueiroa , J. N. 2000 . Effectiveness of three regime using ferroussulfate to the pregnant women . Review. Pan. Am. J. Public Health. , 15 : 313 – 319 .
   Google Scholar
• Diaz , J. R. , De Las , C. A. and Rodrique , R. 2003 . Micronutrient deficiencies in developing and affluent countries . Eur. J. Clinic. Nutr , 57 : S70 – S72 .
   PubMed Web of Science ®Google Scholar
• Dodd , J. , Dare , M. R. and Middleton , P. 2004 . Treatment for women with postpartum iron deficiency anaemia , Vol. 18 , CD004222 Cochrane Database Syst Rev .
   Google Scholar
• Ezzati , M. , Lopez , A. D. , Rodgers , A. A. and Cristopher , J. L. M. 2004 . Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributable to Selected Major Risk Factors , Geneva , , Switzerland : World Health Organization .
   Google Scholar
• FAO/WHO . 1988 . Requirements of Vitamin A, Iron, Folate and Vitamin B12. Report of a Joint FAO/WHO Expert Consultation , FAO Food and Nutrition Series No. 23 Rome : FAO .
   Google Scholar
• Ferreira da Silva , L. , Dutra-de-Oliveira , J. E. and Marchini , J. S. 2004 . Serum iron analysis of adults receiving three different iron compounds . Nutr. Res , 24 : 603 – 611 .
   Web of Science ®Google Scholar
• FFI . 2011 . Country Profile data . http://www.sph.emory.edu/wheatflour/globalmap.php. Assessed 2nd, October 2011
   Google Scholar
• Fischer Walker , C. , Kordas , K. , Stoltzfus , R. J. and Black , R. E. 2005 . Interactive effects of iron and zinc on biochemical and functional outcomes in supplementation trials . Am. J. Clin. Nutr. , 82 : 5 – 12 .
   PubMed Web of Science ®Google Scholar
• Food Security Statistics . 2008 . Food Security Statistics. The State of Food Insecurity in the World , Italy : Food and Agricultural Organization .
   Google Scholar
• Garn , S. M. , Ridella , S. A. , Petzold , A. S. and Falkner , F. 1981 . Maternal hematological levels and pregnancy outcome . Semin. Perinatol , 5 : 155 – 162 .
   PubMed Web of Science ®Google Scholar
• Geerligs , P. P. , Brabin , B. , Mkumbwa , A. , Broadhead , R. and Cuevas , L. E. 2003 . The effect on haemoglobin of the use of iron cooking pots in rural Malawian households in an area with high malaria prevalence: A randomized trial . Trop. Med. Int. Health. , 8 : 310 – 315 .
   PubMed Web of Science ®Google Scholar
• Gibson , R. S. 2006 . Zinc: the missing link in combating micronutrient malnutrition in developing countries . Proc. Nutr. Soc , 65 : 51 – 60 .
   PubMed Web of Science ®Google Scholar
• Gibson , R. S. and Anderson , V. P. 2009 . A review of interventions based on dietary diversification or modification strategies with the potential to enhance intakes of total and absorbable zinc . Food. Nutr. Bull. , 30 : 108S – 143S .
   PubMed Web of Science ®Google Scholar
• Gleason , G. and Scrimshaw , N. S. 2007 . “ An overview of the functional significance of iron deficiency ” . In Nutritional Anemia , Edited by: Kraemer , K. and Zimmermann , M. B. Basel, Switzerland : Sight and Life Press .
   Google Scholar
• Gillespie , S. , Mason , J. B. and Kevany , J. 1991 . “ Controlling iron deficiency: Administrative committee on coordination/subcommittee on nutrition ” . In State-of-the-Art Series: Nutrition Policy, Discussion Paper No. 9 , Geneva , , Switzerland : United Nations .
   Google Scholar
• Golub , M. S. , Hogrefe , C. E. , Tarantal , A. F. , Germann , S. L. , Beard , J. L. , Georgieff , M. K. , Calatroni , A. and Lozoff , B. 2006 . Diet induces iron deficiency anemia and pregnancy outcomes in Rhesus monkeys . Am. J. Clin. Nutr , 83 : 647 – 656 .
   PubMed Web of Science ®Google Scholar
• Government of Pakistan . 2008 . Economic Survey of Pakistan , Islamabad : Finance Division, Economic Adviser's Wing .
   Google Scholar
• Green , R. 1968 . Body iron excretion in man: A colloborative study . Am. J. Med , 4 : 336 – 353 .
   Google Scholar
• Greer , P. G. , Foerster , J. and Lukens , J. N. 2008 . Wintrobe's Clinical Hematology, 12th ed , Philadelphia , , USA : Lippincott Williams and Wilkins .
   Google Scholar
• Gregory , P. and Taslim , A. 2001 . Health status of Pakistani population: A health profile and comparison with the United States . Am. J. Public Health , 91 : 93 – 98 .
   PubMed Web of Science ®Google Scholar
• Grinder-Pedersen , L. , Bukhave , K. , Jensen , M. , Hojgaard , L. and Hansen , M. C. 2004 . Calcium from milk or calcium-fortified foods does not inhibit nonheme-iron absorption from a whole diet consumed over a 4-d period . Am. J. Clin. Nutr. , 80 : 404 – 409 .
   PubMed Web of Science ®Google Scholar
• Groff , J. L. and Gropper , S. S. 2000 . Advanced Nutrition and Human Metabolism , Edited by: Belmont , C. A. 402 – 419 . Wadsworth, California .
   Google Scholar
• Haidar , J. , Omwega , A. M. , Muroki , N. M. and Ayana , G. 2003 . Daily versus weekly iron supplementation and prevention of iron deficiency anaemia in lactating women . East Afr. Med. J , 80 : 11 – 16 .
   PubMedGoogle Scholar
• Haider , B. , Yakoob , M. and Bhutta , Z. 2011 . Effect of multiple micronutrient supplementation during pregnancy on maternal and birth outcomes . BMC Public Health , 11 : S1 – S19 .
   PubMedGoogle Scholar
• Hallberg , L. 1966 . Menstrual blood loss - A population study. Variation at different ages and attempts to define normality . Acta Obstet. Gynecol. Scand , 45 : 320 – 351 .
   PubMed Web of Science ®Google Scholar
• Hallberg , L. 1988 . “ Iron balance in pregnancy ” . In Vitamins and Minerals in Pregnancy and Lactation: Nestlé Nutrition Workshop Series , Edited by: Berger , H. 115 – 127 . New York : Raven Press .
   Google Scholar
• Hallberg , L. 1992 . “ Iron balance in pregnancy and lactation ” . In Nutritional Anemias: Nestlé Nutrition Workshop , Edited by: Fomon , S. J. and Zlotkin , S. 13 – 25 . New York : Raven Press, Ltd. .
   Google Scholar
• Hallberg , L. , Brune , M. , Erlandsson , M. , Sandberg , A. S. and Rossander-Hultén , L. 1991 . Calcium: effect of different amounts of nonhaeme- and haeme-iron absorption in humans . Am. J. Clin. Nutr , 52 : 112 – 119 .
   Google Scholar
• Hallberg , L. , Hoppe , M. , Andersson , M. and Hulthen , L. 2003 . The role of meat to improve the critical iron balance during weaning . Pediatrics , 111 : 864 – 870 .
   PubMed Web of Science ®Google Scholar
• Hallberg , L. and Rossander-Hulthénm , L. 1991 . Iron requirements in menstruating women . Am. J. Clin. Nutr. , 54 : 1047 – 1058 .
   PubMed Web of Science ®Google Scholar
• Haram , K. , Mortensen , J. H. S. and Wollen , A. L. 2003 . Anemia and micronutrient deficiencies. Reducing maternal deaths and disability during pregnanacy . Br. Med. Bull , 67 : 149 – 160 .
   PubMed Web of Science ®Google Scholar
• Hochman , Z. , van Rees , H. , Carberry , P. S. , Hunt , J. R. , McCown , R. L. , Gartmann , A. , Holzworth , D. , van Rees , S. , Dalgliesh , N. P. , Long , W. , Peake , A. S. , Poulton , P. L. and McClelland , T. 2009 . Re-inventing model-based decision support with Australian dryland farmers. 4. Yield Prophet (R) helps farmers monitor and manage crops in a variable climate . Crop Pasture Sci , 60 : 1057 – 1070 .
   Web of Science ®Google Scholar
• Hotz , C. , Porcayo , M. , Onofre , G. , Garcia-Guerra , A. , Elliott , T. , Jenkowski , S. and Greiner , T. 2008 . Efficacy of iron fortified ultra rice in improving the iron status of women in Mexico . Food Nutr. Bull , 29 : 140 – 149 .
   PubMed Web of Science ®Google Scholar
• Huang , J. , Pray , C. and Rozelle , S. 2002 . Enhancing the crops to feed the poor . Nature , 418 : 678 – 684 .
   PubMed Web of Science ®Google Scholar
• Huma , N. , Rehman , S. , Anjum , F. M. , Murtaza , M. A. and Sheikh , M. A. 2007 . Food fortification: A strategy preventing iron deficiency anemia. A Review . Crit. Rev. Food Sci. Nutr. , 47 : 259 – 265 .
   PubMed Web of Science ®Google Scholar
• Hussain , S. , Maqsood , M. A. and Rahmatullah . 2010 . Increasing grain zinc and yield of wheat for the developing world: A Review . Emir. J. Food Agric , 22 : 326 – 339 .
   Google Scholar
• Irshad , G. , Jafri , S. A. , Kousar , S. and Ali , I. 2011 . Significance of serum ferritin in diagnosis of iron deficiency anemia in pregnant females of Pakistan . Professional Med. J. , 18 : 475 – 478 .
   Google Scholar
• Jaleel , R. and Khan , A. 2008 . Severe anemia and adverse pregnancy outcomes . J. Surg. Pak , 13 : 147 – 150 .
   Google Scholar
• Jiang , T. N. , Christian , P. , Khatry , S. K. , Wu , L. and West , K. P. 2005 . Micronutrient deficiencies in early pregnancy are common, concurrent, and vary by season among rural nepali pregnant women . J. Nutr , 135 : 1106 – 1112 .
   PubMed Web of Science ®Google Scholar
• Jilani , T. N. and Iqbal , M. P. 2010 . Risk associated with mild anemia in apparently healthy individuals: How to combat anemia in general population . Pak. J. Med. Sci , 26 : 990 – 994 .
   Web of Science ®Google Scholar
• Juarez-Vazquez , J. , Bonizzoni , E. and Scotti , A. 2002 . Iron plus folate is more effective than iron alone in the treatment of iron deficiency anaemia in pregnancy: A randomised, double blind clinical trial . Br. J. Obstet. Gynaecol. , 109 : 1009 – 1014 .
   Google Scholar
• Kaltwasser , J. P. , Werner , E. , Schalk , K. , Hansen , C. , Gottschalk , R. and Seidl , C. 1998 . Clinical trial on the effect of regular tea drinking on iron accumulation in genetic haemochromatosis . Gut. , 43 : 699 – 704 .
   PubMed Web of Science ®Google Scholar
• Kasumi , E. , Shoji , M. , Endou , S. , Kishi , Y. , Shibata , T. and Murashige , N. 2006 . Prevalence of anemia among healthy women in 2 metropolitan areas of Japan . Int. J. Hematol , 83 : 217 – 219 .
   PubMedGoogle Scholar
• Keraglu , L. , Pehlivan , E. , Egri , M. , Deperm , C. , Gulsen , G. , Gene , M. F. and Temel , I. 2010 . The prevalence of nutritional anemia in pregnancy in an East Anatolia province, Turkey . Biomed Center Public Health , 10 : 329 – 341 .
   PubMedGoogle Scholar
• Khalil , A. A. , Jabbar , T. , Akhtar , S. and Mohyuddin , S. 2007 . Frequency and types of anemia in an antenatal clinic in the third trimester of pregnancy . Pak. Armed. Forces J , 57 : 273 – 278 .
   Google Scholar
• Khan , M. A. , Akhtar , T. and Niazi , M. 2010 . Prevalence of anemia among University of Peshawar students . JPMI. , 24 : 265 – 269 .
   Google Scholar
• Khan , N. J. and Hall , S. E. 2004 . The determinant of reproductive health service provision by General practitioners in Pakistan . Health Pol. Plan , 19 : 209 – 217 .
   PubMed Web of Science ®Google Scholar
• Khan , Y. P. , Bhutta , S. Z. , Munir , S. and Bhutta , Z. A. 2009 . Maternal health and survival in Pakisrtan: issue and options . J. Obstet. Gyneocol. Canada , 31 : 920 – 929 .
   PubMedGoogle Scholar
• Khatib , L. A. , Obeid , O. , Sibai , A.-M. , Batal , M. , Adra , N. and Hwalla , N. 2006 . Folate deficiency is associated with nutritional anaemia in Lebanese women of childbearing age . Public Health Nutr , 9 : 921 – 927 .
   PubMed Web of Science ®Google Scholar
• Killip , S. , John , M. , Bennet and Chambers , M. D. 2007 . Iron-deficiency anemia . J. Am. Fam. Physicians , 75 : 671 – 678 .
   PubMed Web of Science ®Google Scholar
• Kozuma , S. 2009 . Approaches to anemia in pregnancy . J. Jpn. Med. Assoc , 54 : 214 – 218 .
   Google Scholar
• Lachili , B. , Hininger , I. , Faure , H. , Arnaud , J. , Richard , M. J. , Favier , A. and Roussel , A. M. 2001 . Increased lipid peroxidation in pregnant women after iron and vitamin C supplementation . Biol. Trace Elem. Res. , 83 : 103 – 110 .
   PubMed Web of Science ®Google Scholar
• Layrisse , M. , Chavez , J. F. , Méndez-Castellano , H. , Bosch , V. , Tropper , E. , Bastardo , B. and González , E. 1996 . Early response to the impact of iron fortification in the Venezuelan population . Am. J. Clin. Nutr , 64 : 903 – 907 .
   PubMed Web of Science ®Google Scholar
• Llewelyn-Jones , D. 1965 . Severe anaemia in pregnancy as seen in KualaLumpur . Aust. N Z J. Obstet. Gynaecol. , 5 : 191 – 197 .
   PubMedGoogle Scholar
• Lieberman , E. , Ryan , K. J. and Monsen , R. R. 1988 . Association pf maternal hematocrit with premature labour . Am. J. Obstet. Gynecol , 159 : 107 – 114 .
   PubMed Web of Science ®Google Scholar
• Lind , T. , Lönnerdal , B. , Stenlund , H. , Ismail , D. , Seswandhana , R. , Ekström , E. C. and Persson , L. A. 2003 . A community-based randomized controlled trial of iron and zinc supplementation in Indonesian infants: Interactions between iron and zinc . Am. J. Clin. Nutr , 77 : 883 – 890 .
   PubMed Web of Science ®Google Scholar
• Lone , F. W. , Qureslin , R. N. and Emmanuel , F. 2004 . Maternal anemia and its impact on perinatl outcome in tertiary care hospital in Pakistan . East Meditter. Health , 10 : 801 – 807 .
   PubMedGoogle Scholar
• Lozoff , B. , Corapci , F. , Burden , M. J. , Kaciroti , N. , Barroso , R. A. , Sazawal , S. and Black , M. 2007 . Pre-school aged children with iron deficiency anemia show altered affect and behavior . J. Nutr , 137 : 683 – 689 .
   PubMed Web of Science ®Google Scholar
• Lozoff , B. , Hagen , Mollen , E. and Wolf , A. 2000 . Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy . Pediatr , 105 : 11
   Google Scholar
• McCarty , M. F. 2003 . Hyperinsulinemia may boost both hematocrit and iron absorption by up-regulating activity of hypoxia-inducible factor-1α . Med. Hypoth , 61 : 567 – 573 .
   PubMed Web of Science ®Google Scholar
• McLean , E. , Cogswell , M. , Egli , I. , Wojdyla , D. and de Benoist , B. 2009 . Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993–2005 . Public Health Nutr , 12 : 444 – 454 .
   PubMed Web of Science ®Google Scholar
• McMahon , L. P. 2010 . Iron deficiency in pregnancy . Obstetric Med , 3 : 17 – 24 .
   Google Scholar
• MI . 2004 . Micronutrient Initiative Annual Report , 11 Micronutrient Initiative Group, Ottawa, Canada .
   Google Scholar
• Milman , N. 2011 . Anemia-still a major health problem in many parts of the world! . Ann. Hematol , 4 : 366 – 377 .
   Google Scholar
• Milman , N. , Bergholt , T. , Eriksen , L. , Byg , K. E. , Graudal , N. , Pedersen , P. and Hertz , J. 2005 . Iron prophylaxis during pregnancy—How much iron is needed? A randomized dose-response study of 20–80 mg ferrous iron daily in pregnant women . Acta Obstet. Et. Gynecol. Scandinavica , 84 : 238 – 247 .
   PubMed Web of Science ®Google Scholar
• Molgaard , C. , Kaestel , P. and Michaelsen , K. F. 2005 . Long-term calcium supplementation does not affect the iron status of 12–14-year-old girls . Am. J. Clin. Nutr , 82 : 98 – 102 .
   PubMed Web of Science ®Google Scholar
• Morck , T. , Lynch , S. and Cook , J. 1983 . Inhibition of food iron absorption by coffee . Am. J. Clin. Nutr , 37 : 416 – 420 .
   PubMed Web of Science ®Google Scholar
• Mukhopadhyay , A. , Bhatla , N. , Kriplani , A. , Agarwal , N. and Saxena , R. 2004 . Erythrocyte indices in pregnancy: Effect of intermittent iron supplementation . Natl. Med. J. India , 17 : 135 – 137 .
   PubMed Web of Science ®Google Scholar
• Mumtaz , Z. , Shahab , S. , Butt , N. , Rab , M. A. and de-Muynck , A. 2000 . Daily iron supplemantation is more ffective than twice weekly iron supplementation in prefgnanat women in Pakistan in a randomized double blind clinical trial . J. Nutr , 130 : 2697 – 2202 .
   PubMedGoogle Scholar
• Naz , H. , Sarwar , I. , Fawad , A. and Nisa , A. 2008 . Maternal mortality and mortality due to primary PPH expernce at ayub teaching hospital, Abbottabad . J. Ayub. Med. Coll , 20 : 59 – 65 .
   PubMedGoogle Scholar
• Nestle , P. and Ritu , N. 2000 . Manual for Wheat Flour Fortification with Iron (Part 1) The MOST Project , Azilington, USA : Micronutritent Deficiency Programme .
   Google Scholar
• NMCD . 2011 . “ Iron ” . In Natural Medicines Comprehensive Database http://www.nlm.nih.gov/medlineplus/druginfo/natural/912.html. Accessed 2nd Oct, 2011
   Google Scholar
• NNS . 1988 . “ National nutrition survey of Pakistan ” . In Nutrition Division , Edited by: N. I. , H. Islamabad : Ministry of Planning and Development .
   Google Scholar
• NNS . 2004 . National Nutrition Survey of Pakistan 2001–02 , Islamabad : Nutrition Division, National Institute of Health .
   Google Scholar
• Okley , G. P. 2002 . Delaying fortification of flour . Brit. Med. J. , 324 : 1348 – 1349 .
   PubMedGoogle Scholar
• Olsen , A. , Mwaniki , D. and Krarup , H. H F. 2004 . Low-dose iron supplementation does not increase HIV-1 load . J. Acquir. Immune Defic. Syndr. , 36 : 637 – 638 .
   PubMed Web of Science ®Google Scholar
• PDHS . 2007 . Pakistan Demographic and Health Survey , Islamabad : National Institute of Population Studies and Demographic and Health Surveys .
   Google Scholar
• PHS . 2001 . Pakistan Integrated Household Survey 2000–01 , Edited by: Division , S. Islamabad : Federal Beaureu of Statistics, Government of Pakistan. .
   Google Scholar
• PMDGR . 2005 . Pakistan Millennium Development Goals Report. , Islamabad : Center for Poverty Reduction and Income Distribution, UNDP Planning Commission. .
   Google Scholar
• Population Division . 2009 . Population Division. World Population Prospects: The 2008 Revision , New York , , USA : Department of Economic and Social Affairs. United Nations .
   Google Scholar
• PSLSMS . 2005 . Pakistan Social and Living Standard Measurement Survey 2004–05 , Islamabad : Statistics Division .
   Google Scholar
• Rahim , R. , Shaqfat , T. and Faiz , N. R. 2006 . An analysis of direct causes of maternal mortality . J. Postgrad. Med. Inst , 20 : 86 – 91 .
   Google Scholar
• Ramanthan , G. and Aruthmaran , S. 2006 . Postpartum hemorrhages . J. Obstet. Gyneocol. Canada , 28 : 967 – 973 .
   PubMedGoogle Scholar
• Ranum , P. 2000 . Fortification of high extraction wheat flour . Cereal Foods World , 45 : 267 – 268 .
   Web of Science ®Google Scholar
• Rashid , H. O. , Khatun , F. , Yoshida , Y. , Morita , S. , Chaudhury , N. and Sakamoto , K. 2009 . Iron and iodine deficiencies among under 2 children, adolescent girl, and pregnant women of Bangladesh: Association with common diseases . Nagoya J. Med. Sci. , 71 : 39 – 49 .
   PubMedGoogle Scholar
• Rasmussen , K. M. 2001 . Is there a casual relationship between iron deficiency or iron deficiency anemia and weight at birth, length of gestation and perinatal mortality? . J. Nutr , 131 : 590 – 603 .
   PubMed Web of Science ®Google Scholar
• Rimon , E. , Kagansky , N. , Kagansky , M. , Mechnick , L. , Mashiah , T. , Namir , M. and Levy , S. 2005 . Are we giving too much iron? Low-dose iron therapy is effective in octogenarians . Am. J. Med , 118 : 1142 – 1147 .
   PubMed Web of Science ®Google Scholar
• Rizvi , S. A. , Hatcher , J. , Jehan , I. and Qureshi , R. 2007 . Maternal risk factors associated with lowbirth weight in Karachi: A case–control study . East Mediterr. Health J , 13 : 1343 – 1352 .
   PubMedGoogle Scholar
• Rizwan , F. , Qamarunisa , Habibullah and Memon , A. 2010 . Prevalence of anemia in preganat women and its effect on maternal and fetal morbidity and mortility . Pak. J. Med. Sci , 26 : 92 – 95 .
   Web of Science ®Google Scholar
• Ronsmans , C. and Graham , W. J. 2006 . Maternal mortality: Who, when, where and why . Lancet , : 1 – 12 .
   Google Scholar
• Rossander-Hultén , L. , Brune , M. , Sandström , B. , Lönnerdal , B. and Hallberg , L. 1991 . Competitive inhibition of iron absorption by manganese and zinc . Am. J. Clin. Nutr , 54 : 152 – 156 .
   PubMed Web of Science ®Google Scholar
• Rossander-Hulthén , L. and Hallberg , L. 1996 . “ Prevalence of iron deficiency in adolescents ” . In Iron Nutrition in Health and Diseases , Edited by: Hallberg , L. and Asp , N. G. 149 – 156 . London : John Libby & Co. .
   Google Scholar
• Rybo , G. M. 1966 . Plasminogen activators in the endometrium. I. Methodological aspects and II. Clinical aspects . Acta Obstet. Gynecol. Scand , 45 : 411 – 450 .
   PubMed Web of Science ®Google Scholar
• Rybo , G. M. and Hallberg , L. 1966 . Influence of heredity and environment on normal menstrual blood loss. A study of twins . Acta Obstet. Gynecol. Scand , 45 : 389 – 410 .
   PubMed Web of Science ®Google Scholar
• Sabah , S. , Ramzan , M. and Fatima , I. 2010 . Iron deficiency anemia: Role of nutrtioinal deprivation among female patients reproductive group . Professional Med. J. , 17 : 686 – 690 .
   Google Scholar
• Sheikh , A. A. , Memon , R. A. D. and Saboohi , S. 2010 . Maternal mortality 2007–08. Confidential inquires of Ghulam Mohammad Mahar Medical College Hospital, Sukkar . Prof. Med. J , 17 : 291 – 294 .
   Google Scholar
• Siddiqui , I. A. , Rahman , M. A. and Jaleel , A. 2004 . Efficacy of daily vs. weekly supplementation of iron in schoolchildren with low iron status . J. Trop. Pediatr , 50 : 276 – 278 .
   PubMed Web of Science ®Google Scholar
• Sitti-Noor , A. S. , Wan-Maziah , W. M. , Narazah , M. Y. and Quah , B. S. 2006 . Prevalence and risk factors for iron deficiency in Kelantenese pre-school children . Singapore Med. J , 47 : 935 – 939 .
   PubMedGoogle Scholar
• Solomons , N. 1982 . “ Competetive mineral-mineral interaction in the intestine ” . In Nutritional Bioavailability of Zinc , Edited by: Inglett , G. 247 – 271 . Oxford , , UK : American Chemical Society Symposium .
   Google Scholar
• Steer , P. J. 2000 . Maternal hemoglobin concentration and birth weight . Am. J. Clin. Nutr , 71 : 1285 – 1287 .
   PubMed Web of Science ®Google Scholar
• Stoltzfus , R. 1998 . Guidelines for the Use of Iron Supplementation to Prevent and Treat Iron Deficiency Anemia , Geneva : INACG/WHO/UNICEF .
   Google Scholar
• Stoltzfus , R. , Edward-Raj , A. and Dreyfuss , M. 1999 . Clinical pallor is useful to detect severe anemia in populations where anemia is prevalent and severe . J. Nutr , 129 : 1675 – 1681 .
   PubMed Web of Science ®Google Scholar
• Sungthong , R. , Mo-suwan , L. , Chongsuvivatwong , V. and Geater , A. F. 2004 . Once-weekly and 5-days a week iron supplementation differentially affect cognitive function but not school performance in Thai children . J. Nutr , 139 : 2349 – 2354 .
   Google Scholar
• Tolentino , K. and Friedman , J. 2007 . An update on anemia in less developed countries . Am. J. Trop. Med. Hyg , 77 : 44 – 51 .
   PubMed Web of Science ®Google Scholar
• Tufail , A. , Hashmi , H. A. and Naheed , F. 2009 . Risk factors for preterm labour in rural cohort . Med. Channel , 15 : 55 – 57 .
   Google Scholar
• Ullmann , U. , Haller , J. , Bakker , G. C. , Brink , E. J. and Weber , P. 2005 . Epigallocatechin gallate (EGCG) (TEAVIGO) does not impair nonhaem-iron absorption in man . Phytomedicine , 12 : 410 – 415 .
   PubMed Web of Science ®Google Scholar
• UNDP . 2006 . Millinium Targat Goals of Pakistan http://undp.org.pk/images/publications/MDG%202006.pdf. Accessed on 5th September, 2011.
   Google Scholar
• UNICEF . 2002 . Prevention and Control of Nutritional Anaemia: A South Asia Priority , Kathmandu , , Nepal : UNICEF Regional Office for South Asia .
   Google Scholar
• UNICEF . 2009 . The State of theWorld's Children , Kathmandu , , Nepal : United Nations Children's Fund UNICEF Regional Office for South Asia .
   Google Scholar
• Verdon , F. , Burnand , B. , Stubi , C. L. , Bonard , C. , Graff , M. , Michaud , A. , Bischoff , T. , de Vevey , M. , Studer , J. P. , Herzig , L. , Chapuis , C. , Tissot , J. , Pécoud , A. and Favrat , B. 2003 . Iron supplementation for unexplained fatigue in non-anaemic women: Double blind randomised placebo controlled trial (Primary care) . Br. Med. J. , 326 : 1124
   PubMed Web of Science ®Google Scholar
• Wadhwa , P. D. , Garity , T. J. , Porto , M. , Glynn , L. , Chicz-DeMet , A. , Dunkel-Schetter , C. and Sandman , C. A. 2004 . Placental corticotrophin-releasing harmone (CRH), spontaneous preterm birth, and fetal growth restriction: A prospective investigation . Am. J. Obstet. Gyneocol , 191 : 1063 – 1069 .
   PubMed Web of Science ®Google Scholar
• Wali , A. and Nilofour . 2002 . Comparative study- efficacy, safety and compliance of intravenous iron sucrose and intramuscular iron sorbitol in iron deficiency anemia of preganacy . J. Pak. Med. Assoc , 52 : 392 – 395 .
   PubMedGoogle Scholar
• Waqar , F. , Khan , N. A. , Sadia , S. and Sultana , S. 2008 . Fetal outcomes in pregnancy with anemia . Pak. J. Pathol , 19 : 53 – 57 .
   Google Scholar
• Warrell , D. , Cox , T. , Firth , J. and Benz , E. 2003 . Oxford Textbook of Medicine , Oxford , , UK : Oxford University Press .
   Google Scholar
• WHO . 2001 . Iron-deficiency anemia, Assessment, Prevention and Control. , Geneva , , Switzerland : World Health Organization .
   Google Scholar
• WHO . 2008 . WHO Global Database on Anaemia Worldwide Prevalence of Anaemia 1993–2005 Geneva , , Switzerland : World Health Organization, .
   Google Scholar
• Yakoob and Bhutta . 2011 . Effect of routine iron supplementation with or without folic acid on anemia during pregnancy . BMC. Public Health , 11 : S3 – S21 .
   PubMed Web of Science ®Google Scholar
• Yang , Q. , Yin , S. , Zhao , X. and An , J. 2004 . Effect of daily or once weekly iron supplementation on growth and iron status of preschool children . Wei Sheng Yan Jiu. , 33 : 205 – 207 .
   PubMedGoogle Scholar
• Zimmermann , M. B. and Hurrell , R. F. 2007 . Nutritional iron deficiency . Lancet , 370 : 511 – 520 .
   PubMed Web of Science ®Google Scholar
• Zlotkin , S. 2003 . The role of nutrition in the prevention of iron deficiency anemia in infants, children and adolescents . Can. Med. Assoc. J , 168 : 59 – 63 .
   PubMed Web of Science ®Google Scholar
• Zutshi , N. , Batra , S. , Ahmad , S. S. , Khera , N. , Chauhan , G. and Ghandi , G. 2004 . Inject able iron supplementation instead of oral therapy for antenatal care . J. Obstet. Gyneocol. India , 54 : 37 – 38 .
   Google Scholar