1,348
Views
31
CrossRef citations to date
0
Altmetric
Original Articles

Mediterranean Diet and Cardiovascular Risk: Beyond Traditional Risk Factors

, , , , &

REFERENCES

  • Ambrose, J. A. and Barua, R. S. (2004). The pathophysiology of cigarette smoking and cardiovascular disease: An update. J. Am. Coll. Cardiol. 43:1731–1737.
  • Anderson, R. A., Evans, M. L., Ellis, G. R., Graham, J., Morris, K., Jackson, S. K., Lewis, M. J., Rees, A. and Frenneaux, M. P. (2001). The relationships between post-prandial lipaemia, endothelial function and oxidative stress in healthy individuals and patients with type 2 diabetes. Atherosclerosis 154:475–483.
  • Antonopoulou, S., Fragopoulou, E., Karantonis, H. C., Mitsou, E., Sitara, M., Rementzis, J., Mourelatos, A., Ginis, A. and Phenekos, C. (2006). Effect of traditional Greek Mediterranean meals on platelet aggregation in normal subjects and in patients with type 2 diabetes mellitus. J. Med. Food 9:356–362.
  • Avellone, G., Cordova, R., Scalffidi, L. and Bompiani, G. (1998). Effects of Mediterranean diet on lipid, coagulative and fibrinolytic parameters in two randomly selected population samples in Western Sicily. Nutr. Metab. Cardiovasc. Dis. 8:287–296.
  • Bach-Faig, A., Geleva, D., Carrasco, J. L., Ribas-Barba, L. and Serra-Majem, L. (2006). Evaluating associations between Mediterranean diet adherence indexes and biomarkers of diet and disease. Public Health Nutr. 9:1110–1117.
  • Bae, J. H., Schwemmer, M., Lee, I. K., Lee, H. J., Park, K. R., Kim, K. Y. and Bassenge, E. (2003). Postprandial hypertriglyceridemia-induced endothelial dysfunction in healthy subjects is independent of lipid oxidation. Int. J. Cardiol. 87:259–267.
  • Bellido, C., Lopez-Miranda, J., Blanco-Colio, L. M., Perez-Martinez, P., Muriana, F. J., Martin-Ventura, J. L., Marin, C., Gomez, P., Fuentes, F., Egido, J. and Perez-Jimenez, F. (2004). Butter and walnuts, but not olive oil, elicit postprandial activation of nuclear transcription factor kappaB in peripheral blood mononuclear cells from healthy men. Am. J. Clin. Nutr. 80:1487–1491.
  • Bellido, C., Lopez-Miranda, J., Perez-Martinez, P., Paz, E., Marin, C., Gomez, P., Moreno, J. A., Moreno, R. and Perez-Jimenez, F. (2006). The Mediterranean and CHO diets decrease VCAM-1 and E-selectin expression induced by modified low-density lipoprotein in HUVECs. Nutr. Metab. Cardiovasc. Dis. 16:524–530.
  • Bermudez, B., Lopez, S., Ortega, A., Varela, L. M., Pacheco, Y. M., Abia, R. and Muriana, F. J. (2011). Oleic acid in olive oil: From a metabolic framework toward a clinical perspective. Curr. Pharm. Des. 17:831–843.
  • Berry, S. E., Tucker, S., Banerji, R., Jiang, B., Chowienczyk, P. J., Charles, S. M. and Sanders, T. A. (2008). Impaired postprandial endothelial function depends on the type of fat consumed by healthy men. J. Nutr. 138:1910–1914.
  • Borissoff, J. I., Spronk, H. M. and ten Cate, H. (2011). The hemostatic system as a modulator of atherosclerosis. N. Engl. J. Med. 364:1746–1760.
  • Bravo-Herrera, M. D., Lopez-Miranda, J., Marin, C., Gomez, P., Gomez, M. J., Moreno, J. A., Perez-Martinez, P., Blanco, A., Jimenez-Gomez, Y. and Perez-Jimenez, F. (2004). Tissue factor expression is decreased in monocytes obtained from blood during Mediterranean or high carbohydrate diets. Nutr. Metab. Cardiovasc. Dis. 14:128–132.
  • Brunelleschi, S., Bardelli, C., Amoruso, A., Gunella, G., Ieri, F., Romani, A., Malorni, W. and Franconi, F. (2007). Minor polar compounds extra-virgin olive oil extract (MPC-OOE) inhibits NF-kappa B translocation in human monocytemacrophages. Pharmacol. Res. 56:542–549.
  • Brunner, H., Cockcroft, J. R., Deanfield, J., Donald, A., Ferrannini, E., Halcox, J., Kiowski, W., Luscher, T. F., Mancia, G., Natali, A., Oliver, J. J., Pessina, A. C., Rizzoni, D., Rossi, G. P., Salvetti, A., Spieker, L.E., Taddei, S. and Webb, D. J. (2005). Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension. J. Hypertens. 23:233–246.
  • Buscemi, S., Verga, S., Tranchina, M.R., Cottone, S. andCerasola, G. (2009). Effects of hypocaloric very-low-carbohydrate diet vs. Mediterranean diet on endothelial function in obese women. Eur. J. Clin. Invest. 39:339–347.
  • Camargo, A., Delgado-Lista, J., Garcia-Rios, A., Cruz-Teno, C., Yubero-Serrano, E. M., Perez-Martinez, P., Gutierrez-Mariscal, F. M., Lora-Aguilar, P., Rodriguez-Cantalejo, F., Fuentes-Jimenez, F., Tinahones, F. J., Malagon, M. M., Perez-Jimenez, F. and Lopez-Miranda, J. (2012). Expression of proinflammatory, proatherogenic genes is reduced by the Mediterranean diet in elderly people. Br. J. Nutr. 108:500–508.
  • Camargo, A., Ruano, J., Fernandez, J. M., Parnell, L. D., Jimenez, A., Santos-Gonzalez, M., Marin, C., Perez-Martinez, P., Uceda, M., Lopez-Miranda, J. and Perez-Jimenez, F. (2010). Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil. BMC Genomics 11:253.
  • Carluccio, M. A., Massaro, M., Bonfrate, C., Siculella, L., Maffia, M., Nicolardi, G., Distante, A., Storelli, C. and De Caterina, R. (1999). Oleic acid inhibits endothelial activation: A direct vascular antiatherogenic mechanism of a nutritional component in the Mediterranean diet. Arterioscler. Thromb. Vasc. Biol. 19:220–228.
  • Carter, S. J., Roberts, M. B., Salter, J. and Eaton, C. B. (2010). Relationship between Mediterranean Diet Score and atherothrombotic risk: Findings from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994. Atherosclerosis 210:630–636.
  • CFSAN Office of Nutritional Products, L.a.D.S.H.a.H.S. (2004). Letter Responding to Health Claim Petition dated August 28, 2003: Monounsaturated Fatty Acids from Olive Oil and Coronary Heart Disease (Docket No 2003Q-0559). "www.cfsan.fda.gov~dmsqhcolive.html#ref" Accessed March 25, 2012.
  • Chrysohoou, C., Panagiotakos, D. B., Pitsavos, C., Das, U. N. and Stefanadis, C. (2004). Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study. J. Am. Coll. Cardiol. 44:152–158.
  • Clarke, R., Halsey, J., Bennett, D. and Lewington, S. (2011). Homocysteine and vascular disease: Review of published results of the homocysteine-lowering trials. J. Inherit. Metab. Dis. 34:83–91.
  • Cuevas, A. M. and Germain, A. M. (2004). Diet and endothelial function. Biol. Res. 37:225–230.
  • Dai, J., Miller, A. H., Bremner, J. D., Goldberg, J., Jones, L., Shallenberger, L., Buckham, R., Murrah, N. V., Veledar, E., Wilson, P. W. and Vaccarino, V. (2008). Adherence to the Mediterranean diet is inversely associated with circulating interleukin-6 among middle-aged men: A twin study. Circulation 117:169–175.
  • De La Cruz, J. P., Del Rio, S., Lopez-Villodres, J. A., Villalobos, M. A., Jebrouni, N. and Gonzalez-Correa, J. A. (2010). Virgin olive oil administration improves the effect of aspirin on retinal vascular pattern in experimental diabetes mellitus. Br. J. Nutr. 104:560–565.
  • Dedoussis, G. V., Kanoni, S., Mariani, E., Cattini, L., Herbein, G., Fulop, T., Varin, A., Rink, L., Jajte, J., Monti, D., Marcellini, F., Malavolta, M. and Mocchegiani, E. (2008). Mediterranean diet and plasma concentration of inflammatory markers in old and very old subjects in the ZINCAGE population study. Clin. Chem. Lab. Med. 46:990–996.
  • Delgado-Lista, J., Garcia-Rios, A., Perez-Martinez, P., Fuentes, F., Jimenez-Gomez, Y., Gomez-Luna, M. J., Parnell, L. D., Marin, C., Lai, C. Q., Perez-Jimenez, F., Ordovas, J. M. and Lopez-Miranda, J. (2011). Gene variations of nitric oxide synthase regulate the effects of a saturated fat rich meal on endothelial function. Clin. Nutr. 30:234–238.
  • Delgado-Lista, J., Garcia-Rios, A., Perez-Martinez, P., Lopez-Miranda, J. and Perez-Jimenez, F. (2011). Olive oil and haemostasis: Platelet function, thrombogenesis and fibrinolysis. Curr. Pharm. Des. 17:778–785.
  • Delgado-Lista, J., Garcia-Rios, A., Perez-Martinez, P., Solivera, J., Yubero-Serrano, E. M., Fuentes, F., Parnell, L. D., Shen, J., Gomez, P., Jimenez-Gomez, Y., Gomez-Luna, M. J., Marin, C., Belisle, S. E., Rodriguez-Cantalejo, F., Meydani, S. N., Ordovas, J. M., Perez-Jimenez, F. and Lopez-Miranda, J. (2011). Interleukin 1B variant -1473GC (rs1143623) influences triglyceride and interleukin 6 metabolism. J. Clin. Endocrinol. Metab. 96:E816–E820.
  • Delgado-Lista, J., Lopez-Miranda, J., Cortes, B., Perez-Martinez, P., Lozano, A., Gomez-Luna, R., Gomez, P., Gomez, M. J., Criado, J., Fuentes, F. and Perez-Jimenez, F. (2008). Chronic dietary fat intake modifies the postprandial response of hemostatic markers to a single fatty test meal. Am. J. Clin.Nutr. 87:317–322.
  • Delgado-Lista, J., Perez-Martinez, P., Lopez-Miranda, J. and Perez-Jimenez, F. (2012). Long chain omega-3 fatty acids and cardiovascular disease: A systematic review. Br. J. Nutr. 107:Suppl 2, S201–S213.
  • Den Heijer, M., Lewington, S. and Clarke, R. (2005). Homocysteine, MTHFR and risk of venous thrombosis: A meta-analysis of published epidemiological studies. J. Thromb. Haemost. 3:292–299.
  • Desjardins, F. and Balligand, J. L. (2006). Nitric oxide-dependent endothelial function and cardiovascular disease. Acta Cl. Belg. 61:326–334.
  • Di Minno, M. N., Tremoli, E., Coppola, A., Lupoli, R. and Di Minno, G. (2010). Homocysteine and arterial thrombosis: Challenge and opportunity. Thromb. Haemost. 103:942–961.
  • EFSA. (2011). Scientific Opinion on the substantiation of health claims related to polyphenols in olive and protection of LDL particles from oxidative damage (ID 1333, 1638, 1639, 1696, 2865), maintenance of normal blood HDL cholesterol concentrations (ID 1639), maintenance of normal blood pressure (ID 3781), “anti-inflammatory properties” (ID 1882), “contributes to the upper respiratory tract health” (ID 3468), “can help to maintain a normal function of gastrointestinal tract” (3779), and “contributes to body defences against external agents” (ID 3467) pursuant to Article 13(1) of Regulation (EC) No 19242006. EFSA J. 9:2033–2058.
  • Esposito, K., Ciotola, M. and Giugliano, D. (2006). Mediterranean diet, endothelial function and vascular inflammatory markers. Public Health Nutr. 9:1073–1076.
  • Esposito, K., Marfella, R., Ciotola, M., Di Palo, C., Giugliano, F., Giugliano, G., D’Armiento, M., D’Andrea, F. and Giugliano, D. (2004). Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: A randomized trial. JAMA 292:1440–1446.
  • Estruch, R. (2010). Anti-inflammatory effects of the Mediterranean diet: the experience of the PREDIMED study. Proc. Nutr. Soc.69:333–340.
  • Filion, K. B., El Khoury, F., Bielinski, M., Schiller, I., Dendukuri, N. and Brophy, J. M. (2010). Omega-3 fatty acids in high-risk cardiovascular patients: a meta-analysis of randomized controlled trials. BMC Cardiovasc. Disord. 10:24.
  • Finch, J. M. and Joseph, J. (2010). Homocysteine, cardiovascular inflammation, and myocardial remodeling. Cardiovasc. Hematol. Disord. Drug Targets 10:241–245.
  • Fuentes, F., Lopez-Miranda, J., Perez-Martinez, P., Jimenez, Y., Marin, C., Gomez, P., Fernandez, J. M., Caballero, J., Delgado-Lista, J. and Perez-Jimenez, F. (2008). Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with alpha-linolenic acid on postprandial endothelial function in healthy men. Br. J. Nutr. 100:159–165.
  • Fuentes, F., Lopez-Miranda, J., Sanchez, E., Sanchez, F., Paez, J., Paz-Rojas, E., Marin, C., Gomez, P., Jimenez-Pereperez, J., Ordovas, J. M. and Perez-Jimenez, F. (2001). Mediterranean and low-fat diets improve endothelial function in hypercholesterolemic men. Ann. Intern. Med. 134:1115–1119.
  • Fung, T. T., McCullough, M. L., Newby, P. K., Manson, J. E., Meigs, J. B., Rifai, N., Willett, W. C. and Hu, F. B. (2005). Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction. Am. J. Clin. Nutr. 82:163–173.
  • Gillet, L., Roger, S., Bougnoux, P., Le Guennec, J. Y. and Besson, P. (2011). Beneficial effects of omega-3 long-chain fatty acids in breast cancer and cardiovascular diseases: Voltage-gated sodium channels as a common feature? Biochimie 93:4–6.
  • Gillingham, L. G., Harris-Janz, S. and Jones, P. J. (2011). Dietary monounsaturated fatty acids are protective against metabolic syndrome and cardiovascular disease risk factors. Lipids 46:209–228.
  • Gissi, H. F. I., Tavazzi, L., Maggioni, A. P., Marchioli, R., Barlera, S., Franzosi, M. G., Latini, R., Lucci, D., Nicolosi, G. L., Porcu, M. and Tognoni, G. (2008). Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): A randomised, double-blind, placebo-controlled trial. Lancet 372:1223–1230.
  • Giugliano, D. and Esposito, K. (2008). Mediterranean diet and metabolic diseases. Curr. Opin. Lipidol. 19:63–68.
  • Gonzalez-Correa, J. A., Navas, M. D., Munoz-Marin, J., Trujillo, M., Fernandez-Bolanos, J. and de la Cruz, J. P. (2008). Effects of hydroxytyrosol and hydroxytyrosol acetate administration to rats on platelet function compared to acetylsalicylic acid. J. Agric. Food Chem. 56:7872–7876.
  • Goode, G. K., Garcia, S. and Heagerty, A. M. (1997). Dietary supplementation with marine fish oil improves in vitro small artery endothelial function in hypercholesterolemic patients: A double-blind placebo-controlled study. Circulation 96:2802–2807.
  • Halcox, J. P., Schenke, W. H., Zalos, G., Mincemoyer, R., Prasad, A., Waclawiw, M. A., Nour, K. R. and Quyyumi, A. A. (2002). Prognostic value of coronary vascular endothelial dysfunction. Circulation 106:653–658.
  • Harris, W. S., Miller, M., Tighe, A. P., Davidson, M. H. and Schaefer, E. J. (2008). Omega-3 fatty acids and coronary heart disease risk: Clinical and mechanistic perspectives. Atherosclerosis 197:12–24.
  • Homocysteine Studies Collaboration. (2002). Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis. JAMA 288:2015–2022.
  • Jackson, K. G., Poppitt, S. D. and Minihane, A. M. (2012). Postprandial lipemia and cardiovascular disease risk: Interrelationships between dietary, physiological and genetic determinants. Atherosclerosis 220:22–33.
  • Jansen, S., Lopez-Miranda, J., Castro, P., Lopez-Segura, F., Marin, C., Ordovas, J.M., Paz, E., Jimenez-Pereperez, J., Fuentes, F. and Perez-Jimenez, F. (2000). Low-fat and high-monounsaturated fatty acid diets decrease plasma cholesterol ester transfer protein concentrations in young, healthy, normolipemic men. Am. J. Clin. Nutr. 72:36–41.
  • Jimenez-Gomez, Y., Lopez-Miranda, J., Blanco-Colio, L. M., Marin, C., Perez-Martinez, P., Ruano, J., Paniagua, J. A., Rodriguez, F., Egido, J. andPerez-Jimenez, F. (2009). Olive oil and walnut breakfasts reduce the postprandial inflammatory response in mononuclear cells compared with a butter breakfast in healthy men. Atherosclerosis 204:e70–e76.
  • Jimenez-Morales, A. I., Ruano, J., Delgado-Lista, J., Fernandez, J. M., Camargo, A., Lopez-Segura, F., Villarraso, J. C., Fuentes-Jimenez, F., Lopez-Miranda, J. and Perez-Jimenez, F. (2011). NOS3 Glu298Asp polymorphism interacts with virgin olive oil phenols to determine the postprandial endothelial function in patients with the metabolic syndrome. J. Clin. Endocrinol. Metab. 96:E1694–E1702.
  • Junker, R., Kratz, M., Neufeld, M., Erren, M., Nofer, J. R., Schulte, H., Nowak-Gottl, U., Assmann, G. and Wahrburg, U. (2001). Effects of diets containing olive oil, sunflower oil, or rapeseed oil on the hemostatic system. Thromb. Haemost. 85:280–286.
  • Junker, R., Pieke, B., Schulte, H., Nofer, R., Neufeld, M., Assmann, G. and Wahrburg, U. (2001). Changes in hemostasis during treatment of hypertriglyceridemia with a diet rich in monounsaturated and n-3 polyunsaturated fatty acids in comparison with a low-fat diet. Thromb. Res. 101:355–366.
  • Kang, Y. J. (2011). Copper and homocysteine in cardiovascular diseases. Pharmacol. Ther. 129:321–331.
  • Karantonis, H. C., Antonopoulou, S. and Demopoulos, C. A. (2002). Antithrombotic lipid minor constituents from vegetable oils. Comparison between olive oils and others. J. Agric. Food Chem. 50:1150–1160.
  • Karantonis, H. C., Antonopoulou, S., Perrea, D. N., Sokolis, D. P., Theocharis, S. E., Kavantzas, N., Iliopoulos, D. G. and Demopoulos, C. A. (2006). In vivo antiatherogenic properties of olive oil and its constituent lipid classes in hyperlipidemic rabbits. Nutr. Metab. Cardiovasc. Dis. 16:174–185.
  • Karatzi, K., Papamichael, C., Karatzis, E., Papaioannou, T. G., Voidonikola, P. T., Vamvakou, G. D., Lekakis, J. and Zampelas, A. (2008). Postprandial improvement of endothelial function by red wine and olive oil antioxidants: A synergistic effect of components of the Mediterranean diet. J. Am. Coll. Nutr. 27:448–453.
  • Kolovou, G. D., Mikhailidis, D. P., Kovar, J., Lairon, D., Nordestgaard, B. G., Ooi, T. C., Perez-Martinez, P., Bilianou, H., Anagnostopoulou, K. and Panotopoulos, G. (2011). Assessment and clinical relevance of non-fasting and postprandial triglycerides: An expert panel statement. Curr. Vasc. Pharmacol. 9:258–270.
  • Konstantinidou, V., Khymenets, O., Fito, M., De La Torre, R., Anglada, R., Dopazo, A. and Covas, M. I. (2009). Characterization of human gene expression changes after olive oil ingestion: An exploratory approach. Folia Biol. (Praha) 55:85–91.
  • Kris-Etherton, P. M., Harris, W. S. and Appel, L. J. (2002). Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106:2747–2757.
  • Lapointe, A., Goulet, J., Couillard, C., Lamarche, B. and Lemieux, S. (2005). A nutritional intervention promoting the Mediterranean food pattern is associated with a decrease in circulating oxidized LDL particles in healthy women from the Quebec City metropolitan area. J. Nutr. 135:410–415.
  • Lavie, C. J., Milani, R. V., Mehra, M. R. and Ventura, H. O. (2009). Omega-3 polyunsaturated fatty acids and cardiovascular diseases. J. Am. Coll. Cardiol. 54:585–594.
  • Leaf, A., Albert, C. M., Josephson, M., Steinhaus, D., Kluger, J., Kang, J. X., Cox, B., Zhang, H. and Schoenfeld, D. (2005). Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake. Circulation 112:2762–2768.
  • Lichtenstein, A. H., Appel, L. J., Brands, M., Carnethon, M., Daniels, S., Franch, H. A., Franklin, B., Kris-Etherton, P., Harris, W. S., Howard, B., Karanja, N., Lefevre, M., Rudel, L., Sacks, F., Van Horn, L., Winston, M. and Wylie-Rosett, J. (2006). Diet and lifestyle recommendations revision 2006: A scientific statement from the American Heart Association Nutrition Committee. Circulation 114:82–96.
  • Llorente-Cortes, V., Estruch, R., Mena, M. P., Ros, E., Gonzalez, M. A., Fito, M., Lamuela-Raventos, R. M. and Badimon, L. (2010). Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk. Atherosclerosis 208:442–450.
  • Lopez-Miranda, J. and Marin, C. (2010). Dietary, physiological, and genetic impacts on postprandial lipid metabolism. In: Fat Detection: Taste, Texture, and Post Ingestive Effects. Montmayeur, J. P. and le Coutre, J., Eds., Boca Raton (FL), CRC Press, pp. 417–463.
  • Lopez-Miranda, J., Delgado-Lista, J., Perez-Martinez, P., Jimenez-Gomez, Y., Fuentes, F., Ruano, J. and Marin, C. (2007). Olive oil and the haemostatic system. Mol. Nutr. Food Res. 51:1249–1259.
  • Lopez-Miranda, J., Perez-Jimenez, F., Ros, E., De Caterina, R., Badimon, L., Covas, M. I., Escrich, E., Ordovas, J. M., Soriguer, F., Abia, R., de la Lastra, C. A., Battino, M., Corella, D., Chamorro-Quiros, J., Delgado-Lista, J., Giugliano, D., Esposito, K., Estruch, R., Fernandez-Real, J. M., Gaforio, J. J., La Vecchia, C., Lairon, D., Lopez-Segura, F., Mata, P., Menendez, J. A., Muriana, F. J., Osada, J., Panagiotakos, D. B., Paniagua, J. A., Perez-Martinez, P., Perona, J., Peinado, M. A., Pineda-Priego, M., Poulsen, H. E., Quiles, J. L., Ramirez-Tortosa, M. C., Ruano, J., Serra-Majem, L., Sola, R., Solanas, M., Solfrizzi, V., de la Torre-Fornell, R., Trichopoulou, A., Uceda, M., Villalba-Montoro, J. M., Villar-Ortiz, J. R., Visioli, F. and Yiannakouris, N. (2010). Olive oil and health: Summary of the II international conference on olive oil and health consensus report, Jaen and Cordoba (Spain) 2008. Nutr. Metab. Cardiovasc. Dis. 20:284–294.
  • Lopez-Miranda, J., Williams, C. and Lairon, D. (2007). Dietary, physiological, genetic and pathological influences on postprandial lipid metabolism. Br. J. Nutr. 98:458–473.
  • Lucas, L., Russell, A. and Keast, R. (2011). Molecular mechanisms of inflammation. Anti-inflammatory benefits of virgin olive oil and the phenolic compound oleocanthal. Curr. Pharm. Des. 17:754–768.
  • Marin, C., Delgado-Lista, J., Ramirez, R., Carracedo, J., Caballero, J., Perez-Martinez, P., Gutierrez-Mariscal, F. M., Garcia-Rios, A., Delgado-Casado, N., Cruz-Teno, C., Yubero-Serrano, E. M., Tinahones, F., Malagon, M. D., Perez-Jimenez, F. and Lopez-Miranda, J. (2012). Mediterranean diet reduces senescence-associated stress in endothelial cells. Age (Dordr). 34:1309–1316.
  • Marin, C., Ramirez, R., Delgado-Lista, J., Yubero-Serrano, E. M., Perez-Martinez, P., Carracedo, J., Garcia-Rios, A., Rodriguez, F., Gutierrez-Mariscal, F. M., Gomez, P., Perez-Jimenez, F. and Lopez-Miranda, J. (2011). Mediterranean diet reduces endothelial damage and improves the regenerative capacity of endothelium. Am. J. Clin. Nutr. 93:267–274.
  • Mena, M. P., Sacanella, E., Vazquez-Agell, M., Morales, M., Fito, M., Escoda, R., Serrano-Martinez, M., Salas-Salvado, J., Benages, N., Casas, R., Lamuela-Raventos, R. M., Masanes, F., Ros, E. and Estruch, R. (2009). Inhibition of circulating immune cell activation: a molecular antiinflammatory effect of the Mediterranean diet. Am. J. Clin. Nutr. 89:248–256.
  • Mente, A., de Koning, L., Shannon, H. S. and Anand, S. S. (2009). A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch. Intern. Med. 169:659–669.
  • Mezzano, D. and Leighton, F. (2003). Haemostatic cardiovascular risk factors: Differential effects of red wine and diet on healthy young. Pathophysiol. Haemost. Thromb. 33:472–478.
  • Mezzano, D., Leighton, F., Strobel, P., Martinez, C., Marshall, G., Cuevas, A., Castillo, O., Panes, O., Munoz, B., Rozowski, J. and Pereira, J. (2003). Mediterranean diet, but not red wine, is associated with beneficial changes in primary haemostasis. Eur. J. Clin. Nutr. 57:439–446.
  • Mihas, C., Kolovou, G. D., Mikhailidis, D. P., Kovar, J., Lairon, D., Nordestgaard, B. G., Ooi, T. C., Perez-Martinez, P., Bilianou, H., Anagnostopoulou, K. and Panotopoulos, G. (2011). Diagnostic value of postprandial triglyceride testing in healthy subjects: A meta-analysis. Curr. Vasc. Pharmacol. 9:271–280.
  • Morris, M. C., Sacks, F. and Rosner, B. (1993). Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation 88:523–533.
  • Mozaffarian, D., Psaty, B. M., Rimm, E. B., Lemaitre, R. N., Burke, G. L., Lyles, M. F., Lefkowitz, D. and Siscovick, D. S. (2004). Fish intake and risk of incident atrial fibrillation. Circulation 110:368–373.
  • Pacheco, Y. M., Bemudez, B., Lopez, S., Abia, R., Villar, J. and Muriana, F. J. (2007). Minor compounds of olive oil have postprandial anti-inflammatory effects. Br. J. Nutr. 98:260–263.
  • Panagiotakos, D. B., Dimakopoulou, K., Katsouyanni, K., Bellander, T.,Grau, M., Koenig, W., Lanki, T., Pistelli, R., Schneider, A. and Peters, A. (2009). Mediterranean diet and inflammatory response in myocardial infarction survivors. Int. J. Epidemiol. 38:856–866.
  • Panagiotakos, D. B., Pitsavos, C., Chrysohoou, C., Skoumas, I. and Stefanadis, C. (2008). Five-year incidence of cardiovascular disease and its predictors in Greece: The ATTICA study. Vasc. Med. 13, 113–121.
  • Park, K. and Mozaffarian, D. (2010). Omega-3 fatty acids, mercury, and selenium in fish and the risk of cardiovascular diseases. Curr. Atheroscler. Rep. 12:414–422.
  • Patsch, J. R., Miesenbock, G., Hopferwieser, T., Muhlberger, V., Knapp, E., Dunn, J. K., Gotto, A. M., Jr. and Patsch, W. (1992). Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. Arterioscler. Thromb. 12:1336–1345.
  • Pellegrini, N., Valtuena, S., Ardigo, D., Brighenti, F., Franzini, L., Del Rio, D., Scazzina, F., Piatti, P. M. and Zavaroni, I. (2010). Intake of the plant lignans matairesinol, secoisolariciresinol, pinoresinol, and lariciresinol in relation to vascular inflammation and endothelial dysfunction in middle age-elderly men and post-menopausal women living in Northern Italy. Nutr. Metab. Cardiovasc. Dis. 20:64–71.
  • Perez-Herrera, A., Delgado-Lista, J., Torres-Sanchez, L. A., Rangel-Zuniga, O. A., Camargo, A., Moreno-Navarrete, J. M., Garcia-Olid, B., Quintana-Navarro, G. M., Alcala-Diaz, J. F., Munoz-Lopez, C., Lopez-Segura, F., Fernandez-Real, J. M., Luque de Castro, M. D., Lopez-Miranda, J. and Perez-Jimenez, F. (2012). The postprandial inflammatory response after ingestion of heated oils in obese persons is reduced by the presence of phenol compounds. Mol. Nutr. Food Res. 56:510–514.
  • Perez-Jimenez, F. (2005). International conference on the healthy effect of virgin olive oil. Eur. J. Clin. Invest. 35:421–424.
  • Perez-Jimenez, F., Alvarez de Cienfuegos, G., Badimon, L., Barja, G., Battino, M., Blanco, A., Bonanome, A., Colomer, R., Corella-Piquer, D., Covas, I., Chamorro-Quiros, J., Escrich, E., Gaforio, J. J., Garcia Luna, P. P., Hidalgo, L., Kafatos, A., Kris-Etherton, P. M., Lairon, D., Lamuela-Raventos, R., Lopez-Miranda, J., Lopez-Segura, F., Martinez-Gonzalez, M. A., Mata, P., Mataix, J., Ordovas, J., Osada, J., Pacheco-Reyes, R., Perucho, M., Pineda-Priego, M., Quiles, J. L., Ramirez-Tortosa, M. C., Ruiz-Gutierrez, V., Sanchez-Rovira, P., Solfrizzi, V., Soriguer-Escofet, F., de la Torre-Fornell, R., Trichopoulos, A., Villalba-Montoro, J. M., Villar-Ortiz, J. R. and Visioli, F. (2005). International conference on the healthy effect of virgin olive oil. Eur. J. Clin. Invest. 35:421–424.
  • Perez-Jimenez, F., Castro, P., Lopez-Miranda, J., Paz-Rojas, E., Blanco, A., Lopez-Segura, F., Velasco, F., Marin, C., Fuentes, F. and Ordovas, J. M. (1999). Circulating levels of endothelial function are modulated by dietary monounsaturated fat. Atherosclerosis 145:351–358.
  • Perez-Jimenez, F., Lista, J. D., Perez-Martinez, P., Lopez-Segura, F., Fuentes, F., Cortes, B., Lozano, A. and Lopez-Miranda, J. (2006). Olive oil and haemostasis: A review on its healthy effects. Public Health Nutr. 9:1083–1088.
  • Perez-Jimenez, F., Lopez-Miranda, J. and Mata, P. (2002). Protective effect of dietary monounsaturated fat on arteriosclerosis: Beyond cholesterol. Atherosclerosis 163:385–398.
  • Perez-Martinez, P., Delgado-Lista, J., Perez-Jimenez, F., Lopez-Miranda, J. (2010). Update on genetics of postprandial lipemia. Atheroscler. Suppl. 11:39–43.
  • Perez-Martinez, P., Garcia-Quintana, J. M., Yubero-Serrano, E. M., Tasset-Cuevas, I., Tunez, I., Garcia-Rios, A., Delgado-Lista, J., Marin, C., Perez-Jimenez, F., Roche, H. M. and Lopez-Miranda, J. (2010). Postprandial oxidative stress is modified by dietary fat: Evidence from a human intervention study. Clin. Sci. (Lond.) 119:251–261.
  • Perez-Martinez, P., Garcia-Rios, A., Delgado-Lista, J., Perez-Jimenez, F. and Lopez-Miranda, J. (2011). Nutrigenetics of the postprandial lipoprotein metabolism: Evidences from human intervention studies. Curr. Vasc. Pharmacol. 9:287–291.
  • Perez-Martinez, P., Lopez-Miranda, J., Blanco-Colio, L., Bellido, C., Jimenez, Y., Moreno, J.A., Delgado-Lista, J., Egido, J. and Perez-Jimenez, F. (2007). The chronic intake of a Mediterranean diet enriched in virgin olive oil, decreases nuclear transcription factor kappaB activation in peripheral blood mononuclear cells from healthy men. Atherosclerosis 194:e141–e146.
  • Perez-Martinez, P., Lopez-Miranda, J., Perez-Jimenez, F. and Ordovas, J. M. (2008). Influence of genetic factors in the modulation of postprandial lipemia. Atheroscler. Suppl. 9:49–55.
  • Perez-Martinez, P., Moreno-Conde, M., Cruz-Teno, C., Ruano, J., Fuentes, F., Delgado-Lista, J., Garcia-Rios, A., Marin, C., Gomez-Luna, M.J., Perez-Jimenez, F., Roche, H. M. and Lopez-Miranda, J. (2010). Dietary fat differentially influences regulatory endothelial function during the postprandial state in patients with metabolic syndrome: from the LIPGENE study. Atherosclerosis 209:533–538.
  • Perez-Martinez, P., Ordovas, J. M., Garcia-Rios, A., Delgado-Lista, J., Delgado-Casado, N., Cruz-Teno, C., Camargo, A., Yubero-Serrano, E. M., Rodriguez, F., Perez-Jimenez, F. and Lopez-Miranda, J. (2011). Consumption of diets with different type of fat influences triacylglycerols-rich lipoproteins particle number and size during the postprandial state. Nutr. Metab. Cardiovasc. Dis. 21:39–45.
  • Phang, M., Lazarus, S., Wood, L. G. and Garg, M. (2011). Diet and thrombosis risk: nutrients for prevention of thrombotic disease. Semin. Thromb. Hemost. 37:199–208.
  • Pitsavos, C., Panagiotakos, D. B., Tzima, N., Chrysohoou, C., Economou, M., Zampelas, A. and Stefanadis, C. (2005). Adherence to the Mediterranean diet is associated with total antioxidant capacity in healthy adults: The ATTICA study. Am. J. Clin. Nutr. 82:694–699.
  • Rallidis, L. S., Lekakis, J., Kolomvotsou, A., Zampelas, A., Vamvakou, G., Efstathiou, S., Dimitriadis, G., Raptis, S. A. and Kremastinos, D. T. (2009). Close adherence to a Mediterranean diet improves endothelial function in subjects with abdominal obesity. Am. J. Clin. Nutr. 90:263–238.
  • Rasmussen, O., Thomsen, C., Ingerslev, J. and Hermansen, K. (1994). Decrease in von Willebrand factor levels after a high-monounsaturated-fat diet in non-insulin-dependent diabetic subjects. Metabolism 43:1406–1409.
  • Renaud, S. and Lanzmann-Petithory, D. (2002). Dietary fats and coronary heart disease pathogenesis. Curr. Atheroscler. Rep. 4:419–424.
  • Riediger, N. D., Othman, R. A., Suh, M. and Moghadasian, M. H. (2009). A systemic review of the roles of n-3 fatty acids in health and disease. J. Am. Diet. Assoc. 109:668–679.
  • Roche, H. M., Zampelas, A., Knapper, J. M., Webb, D., Brooks, C., Jackson, K. G., Wright, J. W., Gould, B. J., Kafatos, A., Gibney, M. J. and Williams, C. M. (1998). Effect of long-term olive oil dietary intervention on postprandial triacylglycerol and factor VII metabolism. Am. J. Clin. Nutr. 68:552–560.
  • Ruano, J., Lopez-Miranda, J., Fuentes, F., Moreno, J. A., Bellido, C., Perez-Martinez, P., Lozano, A., Gomez, P., Jimenez, Y. and Perez Jimenez, F. (2005). Phenolic content of virgin olive oil improves ischemic reactive hyperemia in hypercholesterolemic patients. J. Am. Coll. Cardiol. 46:1864–1868.
  • Salas-Salvado, J., Garcia-Arellano, A., Estruch, R., Marquez-Sandoval, F., Corella, D., Fiol, M., Gomez-Gracia, E., Vinoles, E., Aros, F., Herrera, C., Lahoz, C., Lapetra, J., Perona, J. S., Munoz-Aguado, D., Martinez-Gonzalez, M. A. and Ros, E. (2008). Components of the Mediterranean-type food pattern and serum inflammatory markers among patients at high risk for cardiovascular disease. Eur. J. Clin.Nutr. 62:651–659.
  • Sanders, T. A., de Grassi, T., Miller, G. J. and Morrissey, J. H. (2000). Influence of fatty acid chain length and cistrans isomerization on postprandial lipemia and factor VII in healthy subjects (postprandial lipids and factor VII). Atherosclerosis 149:413–420.
  • Sawashita, N., Naemura, A., Shimizu, M., Morimatsu, F., Ijiri, Y. and Yamamoto, J. (2006). Effect of dietary vegetable and animal proteins on atherothrombosis in mice. Nutrition 22:661–667.
  • Schini-Kerth, V. B., Auger, C., Etienne-Selloum, N. and Chataigneau, T. (2010). Polyphenol-induced endothelium-dependent relaxations role of NO and EDHF. Adv. Pharmacol. 60:133–175.
  • Seo, T., Blaner, W. S. and Deckelbaum, R. J. (2005). Omega-3 fatty acids: molecular approaches to optimal biological outcomes. Curr. Opin. Lipidol. 16:11–18.
  • Serhan, C. N., Chiang, N. and Van Dyke, T. E. (2008). Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators. Nat. Rev. Immunol. 8:349–361.
  • Serrano-Martinez, M., Palacios, M., Martinez-Losa, E., Lezaun, R., Maravi, C., Prado, M., Martinez, J. A. and Martinez-Gonzalez, M. A. (2005). A Mediterranean dietary style influences TNF-alpha and VCAM-1 coronary blood levels in unstable angina patients. Eur. J. Nutr. 44:348–354.
  • Shidfar, F., Froghifar, N., Vafa, M., Rajab, A., Hosseini, S., Shidfar, S. andGohari, M. (2011). The effects of tomato consumption on serum glucose, apolipoprotein B, apolipoprotein A-I, homocysteine and blood pressure in type 2 diabetic patients. Int. J. Food Sci. Nutr. 62:289–294.
  • Silva, K. D., Kelly, C. N., Jones, A. E., Smith, R. D., Wootton, S. A., Miller, G. J. and Williams, C. M. (2003). Chylomicron particle size and number, factor VII activation and dietary monounsaturated fatty acids. Atherosclerosis 166:73–84.
  • Singh, I., Mok, M., Christensen, A. M., Turner, A. H. and Hawley, J. A. (2008). The effects of polyphenols in olive leaves on platelet function. Nutr. Metab. Cardiovasc. Dis. 18:127–132.
  • Sirtori, C. R., Tremoli, E., Gatti, E., Montanari, G., Sirtori, M., Colli, S., Gianfranceschi, G., Maderna, P., Dentone, C. Z. and Testolin, G. (1986). Controlled evaluation of fat intake in the Mediterranean diet: Comparative activities of olive oil and corn oil on plasma lipids and platelets in high-risk patients. Am. J. Clin.Nutr. 44:635–642.
  • Smith, R. D., Kelly, C. N., Fielding, B. A., Hauton, D., Silva, K. D., Nydahl, M. C., Miller, G. J. and Williams, C. M. (2003). Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects. Br. J. Nutr. 90:597–606.
  • Stirban, A., Nandrean, S., Gotting, C., Tamler, R., Pop, A., Negrean, M., Gawlowski, T., Stratmann, B. and Tschoepe, D. (2010). Effects of n-3 fatty acids on macro- and microvascular function in subjects with type 2 diabetes mellitus. Am. J. Clin. Nutr. 91:808–813.
  • Temme, E. H., Mensink, R. P. and Hornstra, G. (1999). Effects of diets enriched in lauric, palmitic or oleic acids on blood coagulation and fibrinolysis. Thromb.Haemost. 81:259–263.
  • Thies, F., Garry, J. M., Yaqoob, P., Rerkasem, K., Williams, J., Shearman, C. P., Gallagher, P. J., Calder, P. C. and Grimble, R. F. (2003). Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: A randomised controlled trial. Lancet 361:477–485.
  • Thomazella, M. C., Goes, M. F., Andrade, C. R., Debbas, V., Barbeiro, D. F., Correia, R. L., Marie, S. K., Cardounel, A. J., daLuz, P. L. and Laurindo, F. R. (2011). Effects of high adherence to Mediterranean or low-fat diets in medicated secondary prevention patients. Am. J. Cardiol. 108:1523–1529.
  • Torres-Urrutia, C., Guzman, L., Schmeda-Hirschmann, G., Moore-Carrasco, R., Alarcon, M., Astudillo, L., Gutierrez, M., Carrasco, G., Yuri, J. A., Aranda, E. and Palomo, I. (2011). Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables. Blood. Coagul. Fibrinolysis 22:197–205.
  • Tozzi Ciancarelli, M. G., Di Massimo, C., De Amicis, D., Ciancarelli, I. and Carolei, A. (2011). Moderate consumption of red wine and human platelet responsiveness. Thromb. Res. 128:124–129.
  • Tripoli, E., Giammanco, M., Tabacchi, G., Di Majo, D., Giammanco, S. and La Guardia, M. (2005). The phenolic compounds of olive oil: Structure, biological activity and beneficial effects on human health. Nutr. Res. Rev. 18:98–112.
  • Turpeinen, A. M. and Mutanen, M. (1999). Similar effects of diets high in oleic or linoleic acids on coagulation and fibrinolytic factors in healthy humans. Nutr. Metab. Cardiovasc. Dis. 9:65–72.
  • Ungvari, Z., Bagi, Z., Feher, A., Recchia, F. A., Sonntag, W. E., Pearson, K., de Cabo, R. and Csiszar, A. (2010). Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am. J. Physiol. Heart Circ. Physiol. 299:H18–H24.
  • Visioli, F. and Galli, C. (1998). The effect of minor constituents of olive oil on cardiovascular disease: New findings. Nutr. Rev. 56:142–147.
  • Williams, C.M. (2001). Beneficial nutritional properties of olive oil: implications for postprandial lipoproteins and factor VII. Nutr. Metab. Cardiovasc. Dis. 11:51–56.
  • Williams, K. T. and Schalinske, K. L. (2010). Homocysteine metabolism and its relation to health and disease. Biofactors 36:19–24.
  • Yamagishi, K., Nettleton, J. A. and Folsom, A. R. (2008). Plasma fatty acid composition and incident heart failure in middle-aged adults: The Atherosclerosis Risk in Communities (ARIC) Study. Am. Heart J. 156:965–974.
  • Zhu, J., Xie, R., Piao, X., Hou, Y., Zhao, C., Qiao, G., Yang, B., Shi, J. and Lu, Y. (2012). Homocysteine enhances clot-promoting activity of endothelial cells via phosphatidylserine externalization and microparticles formation. Amino Acids 43:1243–1250.
  • Zrelli, H., Matsuoka, M., Kitazaki, S., Araki, M., Kusunoki, M., Zarrouk, M. and Miyazaki, H. (2011). Hydroxytyrosol induces proliferation and cytoprotection against oxidative injury in vascular endothelial cells: Role of Nrf2 activation and HO-1 induction. J. Agric. Food Chem. 59:4473–4482.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.