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Original Articles

Prebiotics: A Potential Treatment Strategy for the Chemotherapy-damaged Gut?

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REFERENCES

  • Abdelouhab, K., Rafa, H., Toumi, R., Bouaziz, S., Medjeber, O. and Touil-Boukoffa, C. (2012). Mucosal intestinal alteration in experimental colitis correlates with nitric oxide production by peritoneal macrophages: Effect of probiotics and prebiotics. Immunopharmacol. Immunotoxicol. 34:590–597.
  • Abrams, S. A., Griffin, I. J., Hawthorne, K. M., Liang, L., Gunn, S. K., Darlington, G. and Ellis, K. J. (2005). A combination of prebiotic short- and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents. Am. J. Clin. Nutr. 82:471–476.
  • Agustina, R., Lukito, W., Firmansyah, A., Suhardjo, H. N., Murniati, D. and Bindels, J. (2007). The effect of early nutritional supplementation with a mixture of probiotic, prebiotic, fiber and micronutrients in infants with acute diarrhea in Indonesia. Asia Pac. J. Clin. Nutr. 16:435–442.
  • Alliet, P., Scholtens, P., Raes, M., Hensen, K., Jongen, H., Rummens, J. L., Boehm, G. and Vandenplas, Y. (2007). Effect of prebiotic galacto-oligosaccharide, long-chain fructo-oligosaccharide infant formula on serum cholesterol and triacylglycerol levels. Nutrition. 23:719–723.
  • Araki, Y., Fujiyama, Y., Andoh, A., Koyama, S., Kanauchi, O. and Bamba, T. (2000). The dietary combination of germinated barley foodstuff plus Clostridium butyricum suppresses the dextran sulfate sodium-induced experimental colitis in rats. Scand. J. Gastroenterol. 35:1060–1067.
  • Arslanoglu, S., Moro, G. E. and Boehm, G. (2007). Early supplementation of prebiotic oligosaccharides protects formula-fed infants against infections during the first 6 months of life. J. Nutr. 137:2420–2424.
  • Baffoni, L., Gaggìa, F., Di Gioia, D., Santini, C., Mogna, L. and Biavati, B. (2012). A Bifidobacterium-based synbiotic product to reduce the transmission of C. jejuni along the poultry food chain. Int. J. Food Microbiol. 157:156–161.
  • Bakker-Zierikzee, A. M., Alles, M. S., Knol, J., Kok, F. J., Tolboom, J. J. and Bindels, J. G. (2005). Effects of infant formula containing a mixture of galacto- and fructo-oligosaccharides or viable Bifidobacterium animalis on the intestinal microflora during the first 4 months of life. Br. J. Nutr. 94:783–790.
  • Blijlevens, N. and Sonis, S. (2007). Palifermin (recombinant keratinocyte growth factor-1): A pleiotropic growth factor with multiple biological activities in preventing chemotherapy- and radiotherapy-induced mucositis. Ann. Oncol. 18:817–826.
  • Bogusławska-Tryk, M., Piotrowska, A. and Burlikowska, K. (2012). Dietary fructans and their potential beneficial influence on health and performance parameters in broiler chickens. J. Cent. Eur. Agric. 13:272–291.
  • Bomba, A., Nemcova, R., Gancarcˇı´kova, S., Herich, R., Guba, P. and Mudronˇova, D. (2002). Improvement of the probiotic effect of micro-organisms by their combination with maltodextrins, fructo-oligosaccharides and polyunsaturated fatty acids. Br. J. Nutr. 88:S95–S99.
  • Boukhettala, N., Ibrahim, A., Aziz, M., Vuichoud, J., Saudan, K. Y., Blum, S., Dechelotte, P., Breuille, D. and Coeffier, M. (2010). A diet containing whey protein, free glutamine, and transforming growth factor-beta ameliorates nutritional outcome and intestinal mucositis during repeated chemotherapeutic challenges in rats. J. Nutr. 140:799–805.
  • Bovee-Oudenhoven, I. M., ten Bruggencate, S. J., Lettink-Wissink, M. L. and van der Meer, R. (2003). Dietary fructo-oligosaccharides and lactulose inhibit intestinal colonisation but stimulate translocation of salmonella in rats. Gut. 52:1572–1578.
  • Brand-Miller, J. C., McVeagh, P., McNeil, Y. and Messer, M. (1998). Digestion of human milk oligosaccharides by healthy infants evaluated by the lactulose hydrogen breath test. J. Pediatr. 133:95–98.
  • Brubaker, P. L., Izzo, A., Hill, M. and Drucker, D. J. (1997). Intestinal function in mice with small bowel growth induced by glucagon-like peptide-2. Am. J. Physiol. 272:E1050–1058.
  • Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., Muccioli, G. G. and Delzenne, N. M. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut. 58:1091–1103.
  • Cheah, K. Y., Howarth, G. S., Yazbeck, R., Wright, T. H., Whitford, E. J., Payne, C., Butler, R. N. and Bastian, S. E. (2009). Grape seed extract protects IEC-6 cells from chemotherapy-induced cytotoxicity and improves parameters of small intestinal mucositis in rats with experimentally-induced mucositis. Cancer Biol. Ther. 8:382–390.
  • Cherbut, C., Michel, C. and Lecannu, G. (2003). The prebiotic characteristics of fructooligosaccharides are necessary for reduction of TNBS-induced colitis in rats. J. Nutr. 133:21–27.
  • Choi, K., Lee, S. S., Oh, S. J., Lim, S. Y., Jeon, W. K., Oh, T. Y. and Kim, J. W. (2007). The effect of oral glutamine on 5-fluorouracil/leucovorin-induced mucositis/stomatitis assessed by intestinal permeability test. Clin. Nutr. 26:57–62.
  • Choi, G. H., Park, H. S., Kim, K. R., Choi, H. N., Jang, K. Y., Chung, M. J., Kang, M. J., Lee, D. G. and Moon, W. S. (2008). Increased expression of epidermal growth factor receptor and betacellulin during the early stage of gastric ulcer healing. Mol. Med. Report. 1:505–510.
  • Clarke, J., Butler, R., Howarth, G., Read, L. and Regester, G. (2002). Exposure of oral mucosa to bioactive milk factors reduces severity of chemotherapy-induced mucositis in the hamster. Oral. Oncol. 38:478–485.
  • Clark, M. J., Robien, K. and Slavin, J. L. (2012). Effect of prebiotics on biomarkers of colorectal cancer in humans: A systematic review. Nutr. Rev. 70:436–443.
  • Cool, J. C., Dyer, J. L., Xian, C. J., Butler, R. N., Geier, M. S. and Howarth, G. S. (2005). Pre-treatment with insulin-like growth factor-I partially ameliorates 5-fluorouracil-induced intestinal mucositis in rats. Growth Horm. IGF Res. 15:72–82.
  • Daddaoua, A., Martinez-Plata, E., Lopez-Posadas, R., Vieites, J. M., Gonzalez, M., Requena, P., Zarzuelo, A., Suarez, M. D., de Medina, F. S. and Martinez-Augustin, O. (2007). Active hexose correlated compound acts as a prebiotic and is antiinflammatory in rats with hapten-induced colitis. J. Nutr. 137:1222–1228.
  • Dahlhoff, M., Horst, D., Gerhard, M., Kolligs, F. T., Wolf, E. and Schneider, M. R. (2008). Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice. FEBS Lett. 582:2911–2915.
  • Delzenne, N. M. and Roberfroid, M. R. (1994). Physiological effects of non-digestible oligosaccharides. Lebensm.-Wiss.u. Technol. 27:1–6.
  • de Souza Oliveira, R. P., Perego, P., de Oliveira, M. N. and Converti, A. (2012). Effect of inulin on the growth and metabolism of a probiotic strain of Lactobacillus rhamnosus in co-culture with Streptococcus thermophilus. LWT - Food Sci. Technol. 47:358–363.
  • Eiwegger, T., Stahl, B., Haidl, P., Schmitt, J., Boehm, G., Dehlink, E., Urbanek, R. and Szepfalusi, Z. (2010). Prebiotic oligosaccharides: In vitro evidence for gastrointestinal epithelial transfer and immunomodulatory properties. Pediatr. Allergy Immunol. 21:1179–1188.
  • Fanaro, S., Boehm, G., Garssen, J., Knol, J., Mosca, F., Stahl, B. and Vigi, V. (2005). Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: A review. Acta Paediatr. Suppl. 94:22–26.
  • Fedorak, R. N. and Madsen, K. L. (2004). Probiotics and prebiotics in gastrointestinal disorders. Curr. Opin. Gastroenterol. 20:146–155.
  • Forchielli, M. L. and Walker, W. A. (2005). The role of gut-associated lymphoid tissues and mucosal defence. Br. J. Nutr. 93(Suppl 1):S41–48.
  • Fukuda, M., Komiyama, Y., Mitsuyama, K., Andoh, A., Aoyama, T., Matsumoto, Y. and Kanauchi, O. (2011). Prebiotic treatment reduced preneoplastic lesions through the downregulation of toll like receptor 4 in a chemo-induced carcinogenic model. J. Clin. Biochem. Nutr. 49:57–61.
  • Geraylou, Z., Souffreau, C., Rurangwa, E., D'Hondt, S., Callewaert, L., Courtin, C. M., Delcour, J. A., Buyse, J. and Ollevier, F. (2012). Effects of arabinoxylan-oligosaccharides (AXOS) on juvenile Siberian sturgeon (Acipenser baerii) performance, immune responses and gastrointestinal microbial community. Fish. Shellfish Immunol. (In Press)
  • Gibson, G. R. (1998). Dietary modulation of the human gut microflora using prebiotics. Br. J. Nutr. 80:S209–212.
  • Gibson, R. J., Bowen, J. M., Inglis, M. R., Cummins, A. G. and Keefe, D. M. (2003). Irinotecan causes severe small intestinal damage, as well as colonic damage, in the rat with implanted breast cancer. J. Gastroenterol. Hepatol. 18:1095–1100.
  • Gibson, R. J., Bowen, J. M. and Keefe, D. M. (2005). Palifermin reduces diarrhea and increases survival following irinotecan treatment in tumor-bearing DA rats. Int. J. Cancer. 116:464–470.
  • Gibson, R. J., Keefe, D. M., Clarke, J. M., Regester, G. O., Thompson, F. M., Goland, G. J., Edwards, B. G. and Cummins, A. G. (2002). The effect of keratinocyte growth factor on tumour growth and small intestinal mucositis after chemotherapy in the rat with breast cancer. Cancer Chemother. Pharmacol. 50:53–58.
  • Gibson, G. R. and Roberfroid, M. B. (1995). Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics. J. Nutr. 125:1401–1412.
  • Gibson, R. J., Stringer, A. M., Bowen, J. M., Logan, R. M., Yeoh, A. S., Burns, J., Alvarez, E. and Keefe, D. M. (2007). Velafermin improves gastrointestinal mucositis following irinotecan treatment in tumor-bearing DA rats. Cancer Biol. Ther. 6:541–547.
  • Gopalakrishnan, A., Clinthorne, J. F., Rondini, E. A., McCaskey, S. J., Gurzell, E. A., Langohr, I. M., Gardner, E. M. and Fenton, J. I. (2012). Supplementation with galacto-oligosaccharides increases the percentage of NK cells and reduces colitis severity in smad3-deficient mice. J. Nutr. 142:1336–1342.
  • Gori, A., Rizzardini, G., Van't Land, B., Amor, K. B., van Schaik, J., Torti, C., Quirino, T., Tincati, C., Bandera, A., Knol, J., Benlhassan-Chahour, K., Trabattoni, D., Bray, D., Vriesema, A., Welling, G., Garssen, J. and Clerici, M. (2011). Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: Results of the “COPA” pilot randomized trial. Mucosal. Immunol. 4:554–563.
  • Hosono, A., Ozawa, A., Kato, R., Ohnishi, Y., Nakanishi, Y., Kimura, T. and Nakamura, R. (2003). Dietary fructooligosaccharides induce immunoregulation of intestinal IgA secretion by murine Peyer's patch cells. Biosci. Biotechnol. Biochem. 67:758–764.
  • Howarth, G. S. (2003). Insulin-like growth factor-I and the gastrointestinal system: Therapeutic indications and safety implications. J. Nutr. 133:2109–2112.
  • Howarth, G. S. (2012). Commentary on prebiotic utility in colitis: Will inflammasomics hold the key? J. Nutr. 142:1189–1190.
  • Howarth, G. S., Cool, J. C., Bourne, A. J., Ballard, F. J. and Read, L. C. (1998). Insulin-like growth factor-I (IGF-I) stimulates regrowth of the damaged intestine in rats, when administered following, but not concurrent with, methotrexate. Growth Factors. 15:279–292.
  • Howarth, G. S., Francis, G. L., Cool, J. C., Xu, X., Byard, R. W. and Read, L. C. (1996). Milk growth factors enriched from cheese whey ameliorate intestinal damage by methotrexate when administered orally to rats. J. Nutr. 126:2519–2530.
  • Ibuki, M., Kovacs-Nolan, J., Fukui, K., Kanatani, H. and Mine, Y. (2010). Analysis of gut immune-modulating activity of beta-1,4-mannobiose using microarray and real-time reverse transcription polymerase chain reaction. Poult. Sci. 89:1894–1904.
  • Janardhana, V., Broadway, M. M., Bruce, M. P., Lowenthal, J. W., Geier, M. S., Hughes, R. J. and Bean, A. G. (2009). Prebiotics modulate immune responses in the gut-associated lymphoid tissue of chickens. J. Nutr. 139:1404–1409.
  • Kanauchi, O., Oshima, T., Andoh, A., Shioya, M. and Mitsuyama, K. (2008). Germinated barley foodstuff ameliorates inflammation in mice with colitis through modulation of mucosal immune system. Scand J. Gastroenterol. 43:1346–1352.
  • Kanauchi, O., Serizawa, I., Araki, Y., Suzuki, A., Andoh, A., Fujiyama, Y., Mitsuyama, K., Takaki, K., Toyonaga, A., Sata, M. and Bamba, T. (2003). Germinated barley foodstuff, a prebiotic product, ameliorates inflammation of colitis through modulation of the enteric environment. J. Gastroenterol. 38:134–141.
  • Khan, A. R., Yousaf, M. S., Rehman, H., Zaneb, H., Pasha, T. N., Fatima, N., Khushal, A., Ijaz, A., Ashraf, K. and Afzal, M. (2012). Response of maternally isolated rock pigeons (Columba livia domestica) to different dietary concentrations of mannan-oligosaccharide. Poult. Sci. 91:1598–1603.
  • Kim, J. K., Kim, C. S., Ahn, H. J., Bang, S. R., Kim, S. J., Yoo, H. Y. and Jeong, H. S. (2010). Early recombinant human epidermal growth factor treatment recovers the irradiation-induced decrease of Na+ absorption prior to the definite histological mucositis. Biomed. Pharmacother. 64:594–599.
  • Konieczna, P., Groeger, D., Ziegler, M., Frei, R., Ferstl, R., Shanahan, F., Quigley, E. M., Kiely, B., Akdis, C. A. and O'Mahony, L. (2012). Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: Potential role for myeloid and plasmacytoid dendritic cells. Gut. 61:354–366.
  • Kumar, V., Sinha, A. K., Makkar, H. P., de Boeck, G. and Becker, K. (2012). Dietary roles of non-starch polysachharides in human nutrition: A review. Crit. Rev. Food Sci. Nutr. 52:899–935.
  • Lalla, R. V. and Peterson, D. E. (2006). Treatment of mucositis, including new medications. Cancer J. 12:348–354.
  • Lalla, R. V., Schubert, M. M., Bensadoun, R. J. and Keefe, D. (2006). Anti-inflammatory agents in the management of alimentary mucositis. Support Care Cancer. 14:558–565.
  • Lamsal, B. P. (2012). Production, health aspects and potential food uses of dairy prebiotic galactooligosaccharides. J. Sci. Food Agric. 92:2020–2028.
  • Lara-Villoslada, F., de Haro, O., Camuesco, D., Comalada, M., Velasco, J., Zarzuelo, A., Xaus, J. and Galvez, J. (2006). Short-chain fructooligosaccharides, in spite of being fermented in the upper part of the large intestine, have anti-inflammatory activity in the TNBS model of colitis. Eur. J. Nutr. 45:418–425.
  • Lecerf, J. M., Depeint, F., Clerc, E., Dugenet, Y., Niamba, C. N., Rhazi, L., Cayzeele, A., Abdelnour, G., Jaruga, A., Younes, H., Jacobs, H., Lambrey, G., Abdelnour, A. M. and Pouillart, P. R. (2012). Xylo-oligosaccharide (XOS) in combination with inulin modulates both the intestinal environment and immune status in healthy subjects, while XOS alone only shows prebiotic properties. Br. J. Nutr. 108:1847–1858.
  • Leforestier, G., Blais, A., Blachier, F., Marsset-Baglieri, A., Davila-Gay, A. M., Perrin, E. and Tome, D. (2009). Effects of galacto-oligosaccharide ingestion on the mucosa-associated mucins and sucrase activity in the small intestine of mice. Eur. J. Nutr. 48:457–464.
  • Lindsay, R. J., Geier, M. S., Yazbeck, R., Butler, R. N. and Howarth, G. S. (2010). Orally administered emu oil decreases acute inflammation and alters selected small intestinal parameters in a rat model of mucositis. Br. J. Nutr. 104:513–519.
  • Liu, W., Li, X., Wong, Y. S., Zheng, W., Zhang, Y., Cao, W. and Chen, T. (2012). Selenium nanoparticles as a carrier of 5-fluorouracil to achieve anticancer synergism. ACS Nano. 6:6578–6591.
  • Liu, P., Piao, X. S., Kim, S. W., Wang, L., Shen, Y. B., Lee, H. S. and Li, S. Y. (2008). Effects of chito-oligosaccharide supplementation on the growth performance, nutrient digestibility, intestinal morphology, and fecal shedding of Escherichia coli and Lactobacillus in weaning pigs. J. Anim. Sci. 86:2609–2618.
  • Logan, R. M., Stringer, A. M., Bowen, J. M., Gibson, R. J., Sonis, S. T. and Keefe, D. M. (2009). Is the pathobiology of chemotherapy-induced alimentary tract mucositis influenced by the type of mucotoxic drug administered? Cancer Chemother. Pharmacol. 63:239–251.
  • Logan, R. M., Stringer, A. M., Bowen, J. M., Yeoh, A. S., Gibson, R. J., Sonis, S. T. and Keefe, D. M. (2007). The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: Pathobiology, animal models and cytotoxic drugs. Cancer Treat. Rev. 33:448–460.
  • Looijer-van Langen, M. A. and Dieleman, L. A. (2009). Prebiotics in chronic intestinal inflammation. Inflamm Bowel. Dis. 15:454–462.
  • Maki, K. C., Gibson, G. R., Dickmann, R. S., Kendall, C. W., Oliver Chen, C. Y., Costabile, A., Comelli, E. M., McKay, D. L., Almeida, N. G., Jenkins, D., Zello, G. A. and Blumberg, J. B. (2012). Digestive and physiologic effects of a wheat bran extract, arabino-xylan-oligosaccharide, in breakfast cereal. Nutrition. 28:1115–1121.
  • Mankan, A. K., Lawless, M. W., Gray, S. G., Kelleher, D. and McManus, R. (2009). NF-kappaB regulation: The nuclear response. J. Cell. Mol. Med. 13:631–643.
  • Marotti, I., Bregola, V., Aloisio, I., Di Gioia, D., Bosi, S., Di Silvestro, R., Quinn, R. and Dinelli, G. (2012). Prebiotic effect of soluble fibres from modern and old durum-type wheat varieties on Lactobacillus and Bifidobacterium strains. J. Sci. Food. Agric. 92:2133–2140.
  • Matthews, G. M., Howarth, G. S. and Butler, R. N. (2007). Short-chain fatty acid modulation of apoptosis in the Kato III human gastric carcinoma cell line. Cancer Biol. Ther. 6:1051–1057.
  • Niewold, T. A., Schroyen, M., Geens, M. M., Verhelst, R. S. B. and Courtin, C. M. (2012). Dietary inclusion of arabinoxylan oligosaccharides (AXOS) down regulates mucosal responses to a bacterial challenge in a piglet model. J. Funct. Foods. 4:626–635.
  • Nishimukai, M., Watanabe, J., Taguchi, H., Senoura, T., Hamada, S., Matsui, H., Yamamoto, T., Wasaki, J., Hara, H. and Ito, S. (2008). Effects of epilactose on calcium absorption and serum lipid metabolism in rats. J. Agric. Food Chem. 56:10340–10345.
  • Panter, M. S., Jain, A., Leonhardt, R. M., Ha, T. and Cresswell, P. (2012). Dynamics of major histocompatibility complex class I association with the human peptide-loading complex. J. Biol. Chem. 287:31172–31184.
  • Parnell, J. A. and Reimer, R. A. (2012). Prebiotic fiber modulation of the gut microbiota improves risk factors for obesity and the metabolic syndrome. Gut. Microbes. 3:29–34.
  • Patra, A. K. (2011). Responses of feeding prebiotics on nutrient digestibility, faecal microbiota composition and short-chain fatty acid concentrations in dogs: A meta-analysis. Animal. 5:1743–1750.
  • Pilzner, C., Buhling, F., Reinheckel, T., Chwieralski, C., Rathinasamy, A., Lauenstein, H. D., Wex, T., Welte, T., Braun, A. and Groneberg, D. A. (2012). Allergic airway inflammation in mice deficient for the antigen-processing protease cathepsin E. Int. Arch. Allergy Immunol. 159:367–383.
  • Pratt, V. C., Tappenden, K. A., McBurney, M. I. and Field, C. J. (1996). Short-chain fatty acid-supplemented total parenteral nutrition improves nonspecific immunity after intestinal resection in rats. JPEN J. Parenter. Enteral. Nutr. 20:264–271.
  • Prisciandaro, L. D., Geier, M. S., Butler, R. N., Cummins, A. G. and Howarth, G. S. (2011). Evidence supporting the use of probiotics for the prevention and treatment of chemotherapy-induced intestinal mucositis. Crit. Rev. Food Sci. Nutr. 51:239–247.
  • Qu, Y., Misaghi, S., Izrael-Tomasevic, A., Newton, K., Gilmour, L. L., Lamkanfi, M., Louie, S., Kayagaki, N., Liu, J., Komuves, L., Cupp, J. E., Arnott, D., Monack, D. and Dixit, V. M. (2012). Phosphorylation of NLRC4 is critical for inflammasome activation. Nature. 490:539–542.
  • Rancez, M., Couedel-Courteille, A. and Cheynier, R. (2012). Chemokines at mucosal barriers and their impact on HIV infection. Cytokine. Growth Factor. Rev. 23:233–243.
  • Reid, G. (2005). The importance of guidelines in the development and application of probiotics. Curr. Pharm. Des. 11:11–16.
  • Robbe, C., Capon, C., Coddeville, B. and Michalski, J. C. (2004). Structural diversity and specific distribution of O-glycans in normal human mucins along the intestinal tract. Biochem. J. 384:307–316.
  • Roberfroid, M. B. (1998). Prebiotics and synbiotics: Concepts and nutritional properties. Br. J. Nutr. 80:S197–202.
  • Roberfroid, M. (2007). Prebiotics: The concept revisited. J. Nutr. 137:830S–837S.
  • Roberfroid, M., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R., Rowland, I., Wolvers, D., Watzl, B., Szajewska, H., Stahl, B., Guarner, F., Respondek, F., Whelan, K., Coxam, V., Davicco, M. J., Leotoing, L., Wittrant, Y., Delzenne, N. M., Cani, P. D., Neyrinck, A. M. and Meheust, A. (2010). Prebiotic effects: Metabolic and health benefits. Br. J. Nutr. 104(Suppl 2):S1–63.
  • Rodenburg, W., Keijer, J., Kramer, E., Vink, C., van der Meer, R. and Bovee-Oudenhoven, I. M. (2008). Impaired barrier function by dietary fructo-oligosaccharides (FOS) in rats is accompanied by increased colonic mitochondrial gene expression. BMC Genomics. 9:144.
  • Roncucci, L., Di Donato, P., Carati, L., Ferrari, A., Perini, M., Bertoni, G., Bedogni, G., Paris, B., Svanoni, F., Girola, M. and et al. (1993). Antioxidant vitamins or lactulose for the prevention of the recurrence of colorectal adenomas. Colorectal Cancer Study Group of the University of Modena and the Health Care District 16. Dis. Colon. Rectum. 36:227–234.
  • Salvini, F., Riva, E., Salvatici, E., Boehm, G., Jelinek, J., Banderali, G. and Giovannini, M. (2011). A specific prebiotic mixture added to starting infant formula has long-lasting bifidogenic effects. J. Nutr. 141:1335–1339.
  • Sauer, J., Richter, K. K. and Pool-Zobel, B. L. (2007). Products formed during fermentation of the prebiotic inulin with human gut flora enhance expression of biotransformation genes in human primary colon cells. Br. J. Nutr. 97:928–937.
  • Scharlau, D., Borowicki, A., Habermann, N., Hofmann, T., Klenow, S., Miene, C., Munjal, U., Stein, K. and Glei, M. (2009). Mechanisms of primary cancer prevention by butyrate and other products formed during gut flora-mediated fermentation of dietary fibre. Mutat. Res. 682:39–53.
  • Shigeoka, A. A., Holscher, T. D., King, A. J., Hall, F. W., Kiosses, W. B., Tobias, P. S., Mackman, N. and McKay, D. B. (2007). TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and -independent pathways. J. Immunol. 178:6252–6258.
  • Shimizu, K., Ogura, H., Asahara, T., Nomoto, K., Morotomi, M., Tasaki, O., Matsushima, A., Kuwagata, Y., Shimazu, T. and Sugimoto, H. (2013). Probiotic/synbiotic therapy for treating critically ill patients from a gut microbiota perspective. Dig. Dis. Sci. 58:23–32.
  • Shoaf, K., Mulvey, G. L., Armstrong, G. D. and Hutkins, R. W. (2006). Prebiotic galactooligosaccharides reduce adherence of enteropathogenic Escherichia coli to tissue culture cells. Infect. Immun. 74:6920–6928.
  • Sinclair, H. R., Smejkal, C. W., Glister, C., Kemp, F., van den Heuvel, E., de Slegte, J., Gibson, G. R. and Rastall, R. A. (2008). Sialyloligosaccharides inhibit cholera toxin binding to the GM1 receptor. Carbohydr. Res. 343:2589–2594.
  • Smith, C. L., Geier, M. S., Yazbeck, R., Torres, D. M., Butler, R. N. and Howarth, G. S. (2008). Lactobacillus fermentum BR11 and fructo-oligosaccharide partially reduce jejunal inflammation in a model of intestinal mucositis in rats. Nutr. Cancer. 60:757–767.
  • Sonis, S. T. (2004a). Pathobiology of mucositis. Semin. Oncol. Nurs. 20:11–15.
  • Sonis, S. T. (2004b). The pathobiology of mucositis. Nat. Rev. Cancer. 4:277–284.
  • Sonis, S. T., Elting, L. S., Keefe, D., Peterson, D. E., Schubert, M., Hauer-Jensen, M., Bekele, B. N., Raber-Durlacher, J., Donnelly, J. P. and Rubenstein, E. B. (2004). Perspectives on cancer therapy-induced mucosal injury: Pathogenesis, measurement, epidemiology, and consequences for patients. Cancer. 100:1995–2025.
  • Specian, R. D. and Oliver, M. G. (1991). Functional biology of intestinal goblet cells. Am. J. Physiol. 260:C183–193.
  • Stringer, A. M., Gibson, R. J., Bowen, J. M. and Keefe, D. M. (2009a). Chemotherapy-induced modifications to gastrointestinal microflora: Evidence and implications of change. Curr. Drug. Metab. 10:79–83.
  • Stringer, A. M., Gibson, R. J., Logan, R. M., Bowen, J. M., Yeoh, A. S., Hamilton, J. and Keefe, D. M. (2009b). Gastrointestinal microflora and mucins may play a critical role in the development of 5-Fluorouracil-induced gastrointestinal mucositis. Exp. Biol. Med. (Maywood). 234:430–441.
  • Strowig, T., Henao-Mejia, J., Elinav, E. and Flavell, R. (2012). Inflammasomes in health and disease. Nature. 481:278–286.
  • Sukhotnik, I., Shteinberg, D., Ben Lulu, S., Bashenko, Y., Mogilner, J. G., Ure, B. M., Shaoul, R. and Coran, A. G. (2008a). Effect of transforming growth factor-alpha on enterocyte apoptosis is correlated with EGF receptor expression along the villus-crypt axis during methotrexate-induced intestinal mucositis in a rat. Apoptosis. 13:1344–1355.
  • Sukhotnik, I., Shteinberg, D., Ben Lulu, S., Bashenko, Y., Mogilner, J. G., Ure, B. M., Shaoul, R., Shamian, B. and Coran, A. G. (2008b). Transforming growth factor-alpha stimulates enterocyte proliferation and accelerates intestinal recovery following methotrexate-induced intestinal mucositis in a rat and a cell culture model. Pediatr. Surg. Int. 24:1303–1311.
  • Sung, H. Y. and Choi, Y. S. (2008). Fructooligosaccharide and soy isoflavone suppress colonic aberrant crypt foci and cyclooxygenase-2 expression in dimethylhydrazine-treated rats. J. Med. Food. 11:78–85.
  • Ten Bruggencate, S. J., Bovee-Oudenhoven, I. M., Lettink-Wissink, M. L., Katan, M. B. and van der Meer, R. (2006). Dietary fructooligosaccharides affect intestinal barrier function in healthy men. J. Nutr. 136:70–74.
  • Torres, D. M., Tooley, K. L., Butler, R. N., Smith, C. L., Geier, M. S. and Howarth, G. S. (2008). Lyprinol only partially improves indicators of small intestinal integrity in a rat model of 5-fluorouracil-induced mucositis. Cancer Biol. Ther. 7:295–302.
  • Tran, C. D., Howarth, G. S., Coyle, P., Philcox, J. C., Rofe, A. M. and Butler, R. N. (2003). Dietary supplementation with zinc and a growth factor extract derived from bovine cheese whey improves methotrexate-damaged rat intestine. Am. J. Clin. Nutr. 77:1296–1303.
  • Trevisi, P., De Filippi, S., Minieri, L., Mazzoni, M., Modesto, M., Biavati, B. and Bosi, P. (2008). Effect of fructo-oligosaccharides and different doses of Bifidobacterium animalis in a weaning diet on bacterial translocation and Toll-like receptor gene expression in pigs. Nutrition. 24:1023–1029.
  • van Hoffen, E., Ruiter, B., Faber, J., M'Rabet, L., Knol, E. F., Stahl, B., Arslanoglu, S., Moro, G., Boehm, G. and Garssen, J. (2009). A specific mixture of short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides induces a beneficial immunoglobulin profile in infants at high risk for allergy. Allergy. 64:484–487.
  • van Vliet, M. J., Harmsen, H. J., de Bont, E. S. and Tissing, W. J. (2010). The role of intestinal microbiota in the development and severity of chemotherapy-induced mucositis. PLoS Pathog. 6:e1000879.
  • van't Land, B., Schijf, M., van Esch, B. C., van Bergenhenegouwen, J., Bastiaans, J., Schouten, B., Boon, L. and Garssen, J. (2010). Regulatory T-cells have a prominent role in the immune modulated vaccine response by specific oligosaccharides. Vaccine. 28:5711–5717.
  • Vos, A. P., Haarman, M., Buco, A., Govers, M., Knol, J., Garssen, J., Stahl, B., Boehm, G. and M'Rabet, L. (2006). A specific prebiotic oligosaccharide mixture stimulates delayed-type hypersensitivity in a murine influenza vaccination model. Int. Immunopharmacol. 6:1277–1286.
  • Walton, G. E., Lu, C., Trogh, I., Arnaut, F. and Gibson, G. R. (2012). A randomised, double-blind, placebo controlled cross-over study to determine the gastrointestinal effects of consumption of arabinoxylanoligosaccharides enriched bread in healthy volunteers. Nutr. J. 11:36.
  • Watanabe, J., Nishimukai, M., Taguchi, H., Senoura, T., Hamada, S., Matsui, H., Yamamoto, T., Wasaki, J., Hara, H. and Ito, S. (2008). Prebiotic properties of epilactose. J. Dairy Sci. 91:4518–4526.
  • Willard, M. D., Simpson, R. B., Delles, E. K., Cohen, N. D., Fossum, T. W., Kolp, D. and Reinhart, G. (1994). Effects of dietary supplementation of fructo-oligosaccharides on small intestinal bacterial overgrowth in dogs. Am. J. Vet. Res. 55:654–659.
  • Winkler, J., Butler, R. and Symonds, E. (2007). Fructo-oligosaccharide reduces inflammation in a dextran sodium sulphate mouse model of colitis. Dig. Dis. Sci. 52:52–58.
  • Wright, T. H., Yazbeck, R., Lymn, K. A., Whitford, E. J., Cheah, K. Y., Butler, R. N., Feinle-Bisset, C., Pilichiewicz, A. N., Mashtoub, S. and Howarth, G. S. (2009). The herbal extract, Iberogast, improves jejunal integrity in rats with 5-Fluorouracil (5-FU)-induced mucositis. Cancer Biol. Ther.. 8:923–929.
  • Xu, B., Wang, Y., Li, J. and Lin, Q. (2009). Effect of prebiotic xylooligosaccharides on growth performances and digestive enzyme activities of allogynogenetic crucian carp (Carassius auratus gibelio). Fish. Physiol. Biochem. 35:351–357.
  • Yamamoto, M., Sato, S., Hemmi, H., Sanjo, H., Uematsu, S., Kaisho, T., Hoshino, K., Takeuchi, O., Kobayashi, M., Fujita, T., Takeda, K. and Akira, S. (2002). Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature. 420:324–329.
  • Yamamoto, M., Sato, S., Hemmi, H., Uematsu, S., Hoshino, K., Kaisho, T., Takeuchi, O., Takeda, K. and Akira, S. (2003). TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat. Immunol. 4:1144–1150.
  • Yanahira, S., Morita, M., Aoe, S., Suguri, T., Nakajima, I. and Deya, E. (1995). Effects of lactitol-oligosaccharides on the intestinal microflora in rats. J. Nutr. Sci. Vitaminol. (Tokyo). 41:83–94.
  • Yang, Y., Iji, P. A., Kocher, A., Mikkelsen, L. L. and Choct, M. (2008a). Effects of mannanoligosaccharide and fructooligosaccharide on the response of broilers to pathogenic Escherichia coli challenge. Br. Poult. Sci. 49:550–559.
  • Yang, Y., Iji, P. A., Kocher, A., Thomson, E., Mikkelsen, L. L. and Choct, M. (2008b). Effects of mannanoligosaccharide in broiler chicken diets on growth performance, energy utilisation, nutrient digestibility and intestinal microflora. Br. Poult. Sci. 49:186–194.
  • Yasuda, A., Inoue, K., Sanbongi, C., Yanagisawa, R., Ichinose, T., Tanaka, M., Yoshikawa, T. and Takano, H. (2012). Dietary supplementation with fructooligosaccharides attenuates allergic peritonitis in mice. Biochem. Biophys. Res. Commun. 422:546–550.
  • Zhang, Z. and Li, L. Y. (2012). TNFSF15 modulates neovascularization and inflammation. Cancer Microenviron. 5:237–247.

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