Nutrients and Chemical Pollutants in Fish and Shellfish. Balancing Health Benefits and Risks of Regular Fish Consumption

REFERENCES

• AHANC, American Heart Association Nutrition Committee. (2006). Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation. 114:82–96.
   PubMed Web of Science ®Google Scholar
• Abeywardena, M. Y. and Patten, G. S. (2011). Role of ω3 long-chain polyunsaturated fatty acids in reducing cardio-metabolic risk factors. Endocr. Metab. Immune. Disord. Drug Targets. 11:232–246.
   PubMedGoogle Scholar
• Bocio, A., Domingo, J. L., Falcó, G. and Llobet, J. M. (2007). Concentrations of PCDD/PCDFs and PCBs in fish and seafood from the Catalan (Spain) market: Estimated human intake. Environ. Int. 33:170–175.
   PubMed Web of Science ®Google Scholar
• Bocio, A., Llobet, J. M. and Domingo, J. L. (2004). Human exposure to polychlorinated diphenyl ethers through the diet in Catalonia, Spain. J. Agric. Food Chem. 52:1769–1772.
   PubMed Web of Science ®Google Scholar
• Bocio, A., Llobet, J. M., Domingo, J. L., Corbella, J., Teixidó, A. and Casas, C. (2003). Polybrominated diphenyl ethers (PBDEs) in foodstuffs: Human exposure through the diet. J. Agric. Food Chem. 51:3191–3195.
   PubMed Web of Science ®Google Scholar
• Bocio, A., Nadal, M. and Domingo, J. L. (2005). Human exposure to metals through the diet in Tarragona, Spain: Temporal trend. Biol. Trace Elem. Res. 104:193–201.
   PubMed Web of Science ®Google Scholar
• Brunner, E. J., Mosdøl, A., Witte, D. R., Martikainen, P., Stafford, M., Shipley, M. J. and Marmot, M. G. (2008). Dietary patterns and 15-y risks of major coronary events, diabetes, and mortality. Am. J. Clin. Nutr. 87:1414–1421.
   PubMed Web of Science ®Google Scholar
• Burger, J. and Gochfeld, M. (2009). Perceptions of the risks and benefits of fish consumption: Individual choices to reduce risk and increase health benefits. Environ. Res. 109:343–349.
   PubMed Web of Science ®Google Scholar
• Chen, Q., Cheng, L. Q., Xiao, TH., Zhang, Y. X., Zhu, M., Zhang, R., Li, K., Wang, Y. and Li, Y. (2011). Effects of omega-3 fatty acid for sudden cardiac death prevention in patients with cardiovascular disease: A contemporary meta-analysis of randomized, controlled trials. Cardiovasc. Drugs Ther. 25:259–265.
   PubMed Web of Science ®Google Scholar
• Davidson, M. H., Kling, D. and Maki, K. C. (2011). Novel developments in omega-3 fatty acid-based strategies. Curr. Opin. Lipidol. 22:437–444.
   PubMed Web of Science ®Google Scholar
• de Lorgeril, M. and Salen, P. (2012). New insights into the health effects of dietary saturated and omega-6 and omega-3 polyunsaturated fatty acids. BMC Med. 21:10–50.
   Google Scholar
• Delgado-Lista, J., Perez-Martinez, P., Lopez-Miranda, J. and Perez-Jimenez, F. (2012). Long chain omega-3 fatty acids and cardiovascular disease: A systematic review. Br. J. Nutr. 107:S201–S213.
   PubMed Web of Science ®Google Scholar
• Del Gobbo, L., Tittlemier, S., Diamond, M., Pepper, K., Tague, B., Yeudall, F. and Vanderlinden, L. J. (2008). Cooking decreases observed perfluorinated compound concentrations in fish. J. Agric. Food Chem. 56:7551–7759.
   PubMed Web of Science ®Google Scholar
• Domingo, J. L. (2007). Omega-3 fatty acids and the benefits of fish consumption: Is all that glitters gold?. Environ. Int. 33:993–998.
   PubMed Web of Science ®Google Scholar
• Domingo, J. L. (2011). Influence of cooking processes on the concentrations of toxic metals and various organic environmental pollutants in food: A review of the published literature. Crit. Rev. Food Sci. Nutr. 54:29–37.
   Google Scholar
• Domingo, J. L. (2012a). Polybrominated diphenyl ethers in food and human dietary exposure: A review of the recent scientific literature. Food Chem. Toxicol. 50:238–249.
   PubMed Web of Science ®Google Scholar
• Domingo, J. L. (2012b). Health risks of dietary exposure to perfluorinated compounds. Environ. Int. 40:187–195.
   PubMed Web of Science ®Google Scholar
• Domingo, J. L., Bocio, A., Falcó, G. and Llobet, J. M. (2006). Exposure to PBDEs and PCDEs associated with the consumption of edible marine species. Environ. Sci. Technol. 40:4394–4399.
   PubMed Web of Science ®Google Scholar
• Domingo, J. L., Bocio, A., Falcó, G. and Llobet, J. M. (2007b). Benefits and risks of fish consumption Part I. A quantitative analysis of the intake of omega-3 fatty acids and chemical contaminants. Toxicology. 230:219–226.
   PubMed Web of Science ®Google Scholar
• Domingo, J. L., Bocio, A., Martí-Cid, R. and Llobet, J. M. (2007a). Benefits and risks of fish consumption Part II. RIBEPEIX, a computer program to optimize the balance between the intake of omega-3 fatty acids and chemical contaminants. Toxicology. 230:227–233.
   PubMed Web of Science ®Google Scholar
• Domingo, J. L., Ericson-Jogsten, I., Perelló, G., Nadal, M., Van Bavel, B. and Kärrman, A. (2012). Human exposure to perfluorinated compounds in Catalonia, Spain: Contribution of drinking water and fish and shellfish. J. Agric. Food Chem. 60:4408–4415.
   PubMed Web of Science ®Google Scholar
• Domingo, J. L., Falcó, G., Llobet, J. M., Casas, C., Teixidó, A. and Müller, L. (2003). Polychlorinated naphthalenes in foods: Estimated dietary intake by the population of Catalonia, Spain. Environ. Sci. Technol. 37:2332–2335.
   PubMed Web of Science ®Google Scholar
• Domingo, J. L., Martí-Cid, R., Castell, V. and Llobet, J. M. (2008). Human exposure to PBDEs through the diet in Catalonia, Spain: Temporal trend. A review of recent literature on dietary PBDE intake. Toxicology. 248:25–32.
   PubMed Web of Science ®Google Scholar
• Doyle, V. C. (2007). Nutrition and colorectal cancer risk: A literature review. Gastroenterol. Nurs. 30:178–182.
   PubMed Web of Science ®Google Scholar
• Engler, M. M. and Engler, M. B. (2006). Omega-3 fatty acids: Role in cardiovascular health and disease. J. Cardiovasc. Nurs. 21:17–24.
   PubMed Web of Science ®Google Scholar
• Ericson, I., Martí-Cid, R., Nadal, M., Van Bavel, B., Lindström, G. and Domingo, J. L. (2008). Human exposure to perfluorinated chemicals through the diet: Intake of perfluorinated compounds in foods from the Catalan (Spain) market. J. Agric. Food Chem. 56:1787–1794.
   PubMed Web of Science ®Google Scholar
• Ericson-Jogsten, I., Perelló, G., Llebaria, X., Bigas, E., Martí-Cid, R., Kärrman, A. and Domingo, J. L. (2009). Exposure to perfluorinated compounds in Catalonia, Spain, through consumption of various raw and cooked foodstuffs, including packaged food. Food Chem. Toxicol. 47:1577–1583.
   PubMed Web of Science ®Google Scholar
• Falcó, G., Bocio, A., Llobet, J. M., Domingo, J. L., Casas, C. and Teixidó, A. (2004). Dietary intake of hexachlorobenzene in Catalonia, Spain. Sci. Total Environ. 322:63–70.
   PubMed Web of Science ®Google Scholar
• Falcó, G., Domingo, J. L., Llobet, J. M., Teixidó, A., Casas, C. and Müller, L. (2003). Polycyclic aromatic hydrocarbons in foods: Human exposure through the diet in Catalonia, Spain. J. Food Prot. 66:2325–2331.
   PubMed Web of Science ®Google Scholar
• Falcó, G., Llobet, J. M., Bocio, A. and Domingo, J. L. (2006). Daily intake of arsenic, cadmium, mercury, and lead by consumption of edible marine species. J. Agric. Food Chem. 54:6106–6112.
   PubMed Web of Science ®Google Scholar
• Filion, K. B., El Khoury, F., Bielinski, M., Schiller, I., Dendukuri, N. and Brophy, J. M. (2010). Omega-3 fatty acids in high-risk cardiovascular patients: A meta-analysis of randomized controlled trials. BMC Cardiovasc. Disord. 3:10–24.
   Google Scholar
• Giovannini, C. and Masella, R. (2012). Role of polyphenols in cell death control. Nutr Neurosci. 15:134–149.
   PubMed Web of Science ®Google Scholar
• Guevel, M. R., Sirot, V., Volatier, J. L., and Leblanc, J. C. (2008). A risk-benefit analysis of French high fish consumption: A QALY approach. Risk Anal. 28:37–48.
   PubMed Web of Science ®Google Scholar
• He, K., Song, Y., Daviglus, M. L., Liu, K., Van Horn, L., Dyer, A. R. and Greenland, P. (2004). Accumulated evidence on fish consumption and coronary heart disease mortality: A meta-analysis of cohort studies. Circulation. 109:2705–2711.
   PubMed Web of Science ®Google Scholar
• Hellberg, R. S., Mireles, De Witt, C. A. and Morrissey, M. T. (2012). Risk-benefit analysis of seafood consumption: A review. Compren. Rev. Food Sci. Food Safe. 11:490–517.
   Web of Science ®Google Scholar
• Hennig, B., Ettinger, A. S., Jandacek, R. J., Koo, S., McClain, C., Seifried, H. and Silverstone, A. (2007b). Using nutrition for intervention and prevention against environmental chemical toxicity and associated diseases. Environ. Health Perspect. 115:493–495.
   PubMed Web of Science ®Google Scholar
• Hennig, B., Oesterling, E. and Toborek, M. (2007a). Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis. Nutr. Metab. Cardiovasc. Dis. 17:162–169.
   PubMed Web of Science ®Google Scholar
• Hennig, B., Ormsbee, L., McClain, C. J., Watkins, B. A., Blumberg, B., Bachas, L. G., Sanderson, W., Thompson, C. and Suk, W. A. (2012). Nutrition can modulate the toxicity of environmental pollutants: Implications in risk assessment and human health. Environ. Health Perspect. 120:771–774.
   PubMed Web of Science ®Google Scholar
• Hoekstra, J., Hart, A., Owen, H., Zeilmaker, M., Bokkers, B., Thorgilsson, B. and Gunnlaugsdottir, H. (2013). Fish, contaminants and human health: Quantifying and weighing benefits and risks. Food Chem. Toxicol. 54:18–29.
   Web of Science ®Google Scholar
• Hooper, L., Thompson, R. L., Harrison, R. A., Summerbell, C. D., Ness, A. R., Moore, H. J., Worthington, H. V., Durrington, P. N., Higgins, J. P., Capps, N. E., Riemersma, R. A., Ebrahim, S. B. and Davey Smith, G. (2006). Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: Systematic review. BMJ. 332:752–760.
   PubMed Web of Science ®Google Scholar
• Hu, F. B. and Willett, W. C. (2002). Optimal diets for prevention of coronary heart disease. JAMA. 288:2569–2578.
   PubMed Web of Science ®Google Scholar
• Ismail, H. M. (2005). The role of omega-3 fatty acids in cardiac protection: An overview. Front. Biosci. 10:1079–1088.
   PubMed Web of Science ®Google Scholar
• Järvinen, R., Knekt, P., Rissanen, H. and Reunanen, A. (2006). Intake of fish and long-chain n-3 fatty acids and the risk of coronary heart mortality in men and women. Br. J. Nutr. 95:824–829.
   PubMed Web of Science ®Google Scholar
• Kelley, D. S. and Adkins, Y. (2012). Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects. Proc. Nutr. Soc. 71:322–331.
   PubMed Web of Science ®Google Scholar
• König, A., Bouzan, C., Cohen, J. T., Connor, W. E., Kris-Etherton, P. M., Gray, G. M., Lawrence, R. S., Savitz, D. A. and Teutsch, S. M. (2005). A quantitative analysis of fish consumption and coronary heart disease mortality. Am. J. Prev. Med. 29:335–346.
   PubMed Web of Science ®Google Scholar
• Kris-Etherton, P. M., Grieger, J. A. and Etherton, T. D. (2009). Dietary reference intakes for DHA and EPA. Prostaglandins Leukot. Essent. Fatty Acids. 81:99–104.
   PubMed Web of Science ®Google Scholar
• Kris-Etherton, P. M., Harris, W. S. and Appel, L. J. (2002). Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. American Heart Association Nutrition Committee. Circulation. 106:2747–2757.
   PubMed Web of Science ®Google Scholar
• Li, Q. Q., Loganath, A., Chong, Y. S., Tan, J. and Obbard, J. P. (2006). Persistent organic pollutants and adverse health effects in humans. J. Toxicol. Environ. Health A. 69:1987–2005.
   PubMed Web of Science ®Google Scholar
• Llobet, J. M., Bocio, A., Domingo, J. L., Teixidó, A., Casas, C. and Müller, L. (2003c). Levels of polychlorinated biphenyls in foods from Catalonia, Spain: Estimated dietary intake. J. Food. Prot. 66:479–484.
   PubMed Web of Science ®Google Scholar
• Llobet, J. M., Domingo, J. L., Bocio, A., Casas, C., Teixidó, A. and Müller, L. (2003b). Human exposure to dioxins through the diet in Catalonia, Spain: Carcinogenic and non-carcinogenic risk. Chemosphere. 50:1193–1200.
   PubMed Web of Science ®Google Scholar
• Llobet, J. M., Falcó, G., Bocio, A. and Domingo, J. L. (2006). Exposure to polycyclic aromatic hydrocarbons through consumption of edible marine species in Catalonia, Spain. J. Food Prot. 69:2493–2499.
   PubMed Web of Science ®Google Scholar
• Llobet, J. M., Falcó, G., Bocio, A. and Domingo, J. L. (2007). Human exposure to polychlorinated naphthalenes through the consumption of edible marine species. Chemosphere. 66:1107–1113.
   PubMed Web of Science ®Google Scholar
• Llobet, J. M., Falcó, G., Casas, C., Teixidó, A. and Domingo, J. L. (2003a). Concentrations of arsenic, cadmium, mercury, and lead in common foods and estimated daily intake by children, adolescents, adults, and seniors of Catalonia, Spain. J. Agric. Food Chem. 51:838–842.
   PubMed Web of Science ®Google Scholar
• Mahaffey, K. R. (2004). Fish and shellfish as dietary sources of methylmercury and the omega-3 fatty acids, eicosahexaenoic acid and docosahexaenoic acid: Risks and benefits. Environ. Res. 95:414–428.
   PubMed Web of Science ®Google Scholar
• Mahaffey, K. R., Sunderland, E. M., Chan, H. M., Choi, A. L., Grandjean, P., Mariën, K., Oken, E., Sakamoto, M., Schoeny, R., Weihe, P., Yan, C. H. and Yasutake, A. (2011). Balancing the benefits of n-3 polyunsaturated fatty acids and the risks of methylmercury exposure from fish consumption. Nutr. Rev. 69:493–508.
   PubMed Web of Science ®Google Scholar
• Martí-Cid, R., Bocio, A., Llobet, J. M. and Domingo, J. L. (2008a). Balancing health benefits and chemical risks associated to dietary habits: RIBEFOOD, a new Internet resource. Toxicology. 244:242–248.
   PubMed Web of Science ®Google Scholar
• Martí-Cid, R., Llobet, J. M., Castell, V. and Domingo, J. L. (2008b). Human dietary exposure to hexachlorobenzene in Catalonia, Spain. J. Food Prot. 71:2148–2152.
   PubMed Web of Science ®Google Scholar
• Martí-Cid, R., Llobet, J. M., Castell, V. and Domingo, J. L. (2008c). Human exposure to polychlorinated naphthalenes and polychlorinated diphenyl ethers from foods in Catalonia, Spain: Temporal trend. Environ. Sci. Technol. 42:4195–4201.
   PubMed Web of Science ®Google Scholar
• Martorell, I., Perelló, G., Martí-Cid, R., Castell, V., Llobet, J. M. and Domingo, J. L. (2010). Polycyclic aromatic hydrocarbons (PAH) in foods and estimated PAH intake by the population of Catalonia, Spain: Temporal trend. Environ. Int. 36:424–432.
   PubMed Web of Science ®Google Scholar
• Martorell, I., Perelló, G., Martí-Cid, R., Llobet, J. M., Castell, V. and Domingo, J. L. (2011). Human exposure to arsenic, cadmium, mercury, and lead from foods in Catalonia, Spain: Temporal trend. Biol. Trace Elem. Res. 142:309–322.
   PubMed Web of Science ®Google Scholar
• McManus, A., Merga, M. and Newton, W. (2011). Omega-3 fatty acids. What consumers need to know. Appetite. 57:80–83.
   PubMed Web of Science ®Google Scholar
• Mente, A., de Koning, L., Shannon, H. S. and Anand, S. S. (2009). A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch. Intern. Med. 169:659–669.
   PubMed Web of Science ®Google Scholar
• Mozaffarian, D. and Rimm, E. B. (2006). Fish intake, contaminants, and human health: Evaluating the risks and the benefits. JAMA. 296:1885–1899.
   PubMed Web of Science ®Google Scholar
• Musa-Veloso, K., Binns, M. A., Kocenas, A., Chung, C., Rice, H., Oppedal-Olsen, H., Lloyd, H. and Lemke, S. (2011). Impact of low v. moderate intakes of long-chain n-3 fatty acids on risk of coronary heart disease. Br. J. Nutr. 106:1129–1141.
   PubMed Web of Science ®Google Scholar
• Nettleton, J. A., Polak, J. F., Tracy, R., Burke, G. L. and Jacobs, D. R. (2009). Dietary patterns and incident cardiovascular disease in the multi-ethnic study of atherosclerosis. Am. J. Clin. Nutr. 90:647–654.
   PubMed Web of Science ®Google Scholar
• Oken, E., Choi, A. L., Karagas, M. R., Mariën, K., Rheinberger, C. M., Schoeny, R., Sunderland, E. and Korrick, S. (2012). Which fish should I eat? Perspectives influencing fish consumption choices. Environ. Health Perspect. 120:790–798.
   PubMed Web of Science ®Google Scholar
• Perelló, G., Gómez-Catalán, J., Castell, V., Llobet, J. M. and Domingo, J. L. (2012). Assessment of the temporal trend of the dietary exposure to PCDD/Fs and PCBs in Catalonia, over Spain: Health risks. Food Chem. Toxicol. 50:399–408.
   PubMed Web of Science ®Google Scholar
• Perelló, G., Martí-Cid, R., Castell, V., Llobet, J. M. and Domingo, J. L. (2009a). Influence of various cooking processes on the concentrations of PCDD/Fs, PCBs and PCDEs in foods. J. Food Prot. 21:178–185.
   Google Scholar
• Perelló, G., Martí-Cid, R., Castell, V., Llobet, J. M. and Domingo, J. L. (2009b). Concentrations of polybrominated diphenyl ethers, hexachlorobenzene and polycyclic aromatic hydrocarbons in various foodstuffs before and after cooking. Food Chem. Toxicol. 47:709–715.
   PubMed Web of Science ®Google Scholar
• Perelló, G., Martí-Cid, R., Llobet, J. M. and Domingo, J. L. (2008). Effects of various cooking processes on the concentrations of arsenic, cadmium, mercury, and lead in foods. J. Agric. Food Chem. 56:11262–11269.
   PubMed Web of Science ®Google Scholar
• Pilkington, S. M., Watson, R. E., Nicolaou, A. and Rhodes, L. E. (2011). Omega-3 polyunsaturated fatty acids: Photoprotective macronutrients. Exp. Dermatol. 20:537–543.
   PubMed Web of Science ®Google Scholar
• Pohjola, M. V., Leino, O., Kollanus, V., Tuomisto, J. T., Gunnlaugsdóttir, H., Holm, F., Kalogeras, N., Luteijn, J. M., Magnússon, S. H., Odekerken, G., Tijhuis, M. J., Ueland, Ø., White, B. C. and Verhagen, H. (2012). State of the art in benefit-risk analysis: Environmental health. Food Chem. Toxicol. 50:40–55.
   PubMed Web of Science ®Google Scholar
• Russo, G. L. (2009). Dietary n-6 and n-3 polyunsaturated fatty acids: From biochemistry to clinical implications in cardiovascular prevention. Biochem. Pharmacol. 77:937–946.
   PubMed Web of Science ®Google Scholar
• Sidhu, K. S. (2003). Health benefits and potential risks related to consumption of fish or fish oil. Regul. Toxicol. Pharmacol. 38:336–344.
   PubMed Web of Science ®Google Scholar
• Sioen, I., De Henauw, S., Van Camp, J. and Verh, K. (2007). Evaluation of benefits and risks related to seafood consumption. Acad. Geneeskd. Belg. 69:249–289.
   PubMedGoogle Scholar
• Sioen, I., De Henauw, S., Van Camp, J., Volatier, J. L. and Leblanc, J. C. (2009). Comparison of the nutritional-toxicological conflict related to seafood consumption in different regions worldwide. Regul. Toxicol. Pharmacol. 55:219–228.
   PubMed Web of Science ®Google Scholar
• Sioen, I., De Henauw, S., Verbeke, W., Verdonck, F., Willems, J. L. and Van Camp, J. (2008b). Fish consumption is a safe solution to increase the intake of long-chain n-3 fatty acids. Public Health Nutr. 11:1107–1116
   PubMed Web of Science ®Google Scholar
• Sioen, I., Leblanc, J. C., Volatier, J. L., De Henauw, S. and Van Camp, J. (2008a). Evaluation of the exposure methodology for risk-benefit assessment of seafood consumption. Chemosphere. 73:1582–1588.
   PubMed Web of Science ®Google Scholar
• Sioen, I., Van Camp, J., Verdonck, F., Verbeke, W., Vanhonacker, F., Willems, J. and De Henauw, S. (2008c). Probabilistic intake assessment of multiple compounds as a tool to quantify the nutritional-toxicological conflict related to seafood consumption. Chemosphere. 71:1056–1066.
   PubMed Web of Science ®Google Scholar
• Siriwardhana, N., Kalupahana, N. S. and Moustaid-Moussa, N. (2012). Health benefits of n-3 polyunsaturated fatty acids: Eicosapentaenoic acid and docosahexaenoic acid. Adv. Food Nutr. Res. 65:211–222.
   PubMedGoogle Scholar
• Sirot, V., Leblanc, J. C. and Margaritis, I. (2012). A risk-benefit analysis approach to seafood intake to determine optimal consumption. Br. J. Nutr. 107:1812–1822.
   PubMed Web of Science ®Google Scholar
• Smith, K. M. and Sahyoun, N. R. (2005). Fish consumption: Recommendations versus advisories, can they be reconciled?. Nutr. Rev. 63:39–46.
   PubMed Web of Science ®Google Scholar
• Sydenham E, Dangour, A. D. and Lim, W. S. (2012). Omega 3 fatty acid for the prevention of cognitive decline and dementia. Cochrane Database Syst. Rev. 13:6.
   Google Scholar
• Stern, A. H. (2007). Public health guidance on cardiovascular benefits and risks related to fish consumption. Environ. Health. 23:6–31.
   Google Scholar
• Tijhuis, M. J., de Jong, N., Pohjola, M. V., Gunnlaugsdóttir, H., Hendriksen, M., Hoekstra, J., Holm, F., Kalogeras, N., Leino, O., van Leeuwen, F. X., Luteijn, J. M., Magnússon, S. H., Odekerken, G., Rompelberg, C., Tuomisto, J. T., Ueland, Ø., White, B. C. and Verhagen, H. (2012). State of the art in benefit-risk analysis: Food and nutrition. Food Chem. Toxicol. 50:5–25.
   PubMed Web of Science ®Google Scholar
• Ueland, Ø., Gunnlaugsdottir, H., Holm, F., Kalogeras, N., Leino, O., Luteijn, J. M., Magnússon, S. H., Odekerken, G., Pohjola, M. V., Tijhuis, M. J., Tuomisto, J. T., White, B. C. and Verhagen, H. (2012). State of the art in benefit-risk analysis: Consumer perception. Food Chem. Toxicol. 50:67–76.
   PubMed Web of Science ®Google Scholar
• van den Elsen, L., Garssen, J. and Willemsen, L. (2012). Long chain N-3 polyunsaturated fatty acids in the prevention of allergic and cardiovascular disease. Curr. Pharm. Des. 18:2375–2392.
   PubMed Web of Science ®Google Scholar
• Verbeke, W., Vanhonacker, F., Frewer, L. J., Sioen, I., De Henauw, S. and Van Camp, J. (2008). Communicating risks and benefits from fish consumption: Impact on Belgian consumers’ perception and intention to eat fish. Risk Anal. 28:951–967.
   PubMed Web of Science ®Google Scholar
• Verhagen, H., Tijhuis, M. J., Gunnlaugsdóttir, H., Kalogeras, N., Leino, O., Luteijn, J. M., Magnússon, S. H., Odekerken, G., Pohjola, M. V., Tuomisto, J. T., Ueland, Ø., White, B. C. and Holm, F. (2012). State of the art in benefit-risk analysis: Introduction. Food Chem. Toxicol. 50:2–4.
   PubMed Web of Science ®Google Scholar
• Wang, Q., Liang, X., Wang, L., Lu, X., Huang, J., Cao, J., Li, H. and Gu, D. (2012). Effect of omega-3 fatty acids supplementation on endothelial function: A meta-analysis of randomized controlled trials. Atherosclerosis. 221:536–543.
   PubMed Web of Science ®Google Scholar
• White, S. S. and Birnbaum, L. S. (2009). An overview of the effects of dioxins and dioxin-like compounds on vertebrates, as documented in human and ecological epidemiology. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev. 27:197–211.
   PubMed Web of Science ®Google Scholar