Walnuts (Juglans regia) Chemical Composition and Research in Human Health

REFERENCES

• Ailhaud, G., Guesnet, P. and Cunnane, S. C. (2008). An emerging risk factor for obesity: Does disequilibrium of polyunsaturated fatty acid metabolism contribute to excessive adipose tissue development? Br. J. Nutr. 100:461–470.
   PubMed Web of Science ®Google Scholar
• Alasalvar, C. and Shahidi, F. (2008). Tree Nuts: Composition, Phytochemicals, and Health Effects. CRC Press, Boca Raton, FL.
   Google Scholar
• American Diabetes Association (2004): Nutrition principles and recommendations in diabetes (Position Statement). Diabetes Care 27(Suppl. 1): S36–S46.
   Google Scholar
• Anderson, R. J., Freedland, K. E., Clouse, R. E. and Lustman, P. J. (2001). The prevalence of comorbid depression in adults with diabetes: A meta-analysis. Diabetes Care. 24:1069–1078.
   PubMed Web of Science ®Google Scholar
• Aronis, K. N., Vamvini, M. T. and Chamberland, J. P. (2011). Short-term walnut consumption increases circulating total adiponectin and apolipoprotein a concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: Data from a double blinded, randomized, placebo-controlled study. Metabolism. 61:577–582.
   PubMed Web of Science ®Google Scholar
• Arsenault, B. J., Despres, J. P., Stroes, E. S., Wareham, N. J. and Kastelein, J. J. (2010). Lipid assessment, metabolic syndrome and coronary heart disease risk. Eur. J. Clin. Invest. 40:1081–1093.
   PubMed Web of Science ®Google Scholar
• Asadi Shekaari, M., Kalantaripour, T. P., Arab, N. F., Namazian, E. and Eslami, A. (2012). The anticonvulsant and neuroprotective effects of walnuts on the neurons of rat brain cortex. Avicenna J. Med. Biotech. (AJMB) 4:155–158.
   Google Scholar
• Astrup, A., Dyerberg, J. and Elwood, P. (2011). The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: Where does the evidence stand in 2010? Am. J. Clin. Nutr. 93:684–688.
   PubMed Web of Science ®Google Scholar
• Bhargava, U. C. and Westfall, B. A. (1968). Antitumor activity of Juglans nigra (Black Walnut) extractives. J. Pharm. Sci. 57:1674–1677.
   PubMed Web of Science ®Google Scholar
• Barnett, A. H. (2009). New treatments in type 2 diabetes: A focus on the incretin-based therapies. Clin. Endocrinol. 70:343–353.
   PubMed Web of Science ®Google Scholar
• Bartsch, H., Nair, J. and Owen, R. W. (1999). Dietary PUFAs and cancer of the breast and colorectum: Compelling evidence for their role as risk modifiers. Carcinogenesis. 20:2209–2218.
   PubMed Web of Science ®Google Scholar
• Bashkatova, V., Narkevich, V., Vitskova, G., and Vanin, A. (2003). The influence of anticonvulsant and antioxidant drugs on nitric oxide level and lipid peroxidation in the rat brain during penthylenetetrazole-induced epileptiform model seizures. Prog Neuro-Psychopharmacol. Biol. Psychiatry. 27:487–492.
   PubMed Web of Science ®Google Scholar
• Bate-Smith, E. C. (1972). Detection and determination of ellagitannins. Phytochemistry. 11:1153–1156.
   Web of Science ®Google Scholar
• Baur, J. A. and Sinclair, D. A. (2006). Therapeutic potential of resveratrol: The in vivo evidence. Nature Rev. Drug Discov. 5:493–506.
   PubMed Web of Science ®Google Scholar
• Begin, M. E., Das, U. N., Ells, G. and Horrobin, D. F. (1985). Selective killing of human cancer cells by polyunsaturated fatty acids. Prostaglandins Leukot. Med. 19:177–186.
   PubMedGoogle Scholar
• Berquin, I.M., Edwards, I.J. and Chen, Y.Q. (2008). Multi-targeted therapy of cancer by omega-3 fatty acids. Cancer Letters. 269(2):363–377.
   PubMed Web of Science ®Google Scholar
• Bingham, E. and Morris, S. (1988). Complex mixtures and multiple agent interactions: The issues and their significance. Fundam. Appl. Toxol. 10:549–552.
   PubMedGoogle Scholar
• Bolling, B. W., Chen, C. Y. O., McKay, D. L. and Blumberg, J. B. (2011). The phytochemical composition of tree nuts. Nutr. Res. Rev. 24:244–275.
   PubMed Web of Science ®Google Scholar
• Boukharta, M., Jalbert, G. and Castonguay, A. (1992). Biodistribution of ellagic acid and dose-related inhibition of lung tumorigenesis in A/J mice. Nutr. Cancer. 18:181–189.
   PubMed Web of Science ®Google Scholar
• Brennan, A. M., Sweeney, L. L., Liu, X. and Mantzoros, C.S. (2010). Walnut consumption increases satiation but has no effect on insulin resistance or the metabolic profile over a 4-day period. Obesity 18:1176–1182.
   PubMed Web of Science ®Google Scholar
• Campbell, B. C., Molyneux, R. J. and Schatzki, T. F. (2003). Current research on reducing pre- and post-harvest aflatoxin contamination of US almond, pistachio, and walnut. J. Toxicol. Toxin. Rev. 22:225–266.
   Web of Science ®Google Scholar
• Carrion, J. S., Fuentes, N., Gonzalez-Samperiz, P., Sanchez Quirante, L., Finlayson, J. C., Fernandez, S. and Andrade, A. (2007). Holocene environmental change in a montane region of southern Europe with a long history of human settlement. Quat. Sci. Rev. 26(11–12):1455–1475.
   Web of Science ®Google Scholar
• Carvalho, M., Ferreira, P. J., Mendes, V. S., Silva, R., Pereira, J. A. and Jerónimo, C. (2010). Human cancer cell antiproliferative and antioxidant activities of Juglans regia L. Food Chem. Toxicol. 48:441–447.
   PubMed Web of Science ®Google Scholar
• Casas-Agustench, P., Lopez-Uriarte, P., Ros, E., Bullo, M. and Salas-Salvado, J. (2011a). Nuts, hypertension and endothelial function. Nutr. Met. Cardiovasc. Dis. 21(Suppl. 1):S21–S33.
   PubMedGoogle Scholar
• Casas-Agustench, P., Salas-Huetos, A. and Salas-Salvado, J. (2011b). Mediterranean nuts: Origins, ancient medicinal benefits and symbolism. Public Health Nutr. 14(Suppl. 1):2296–2301.
   PubMed Web of Science ®Google Scholar
• Cerda, B., Tomas-Barneran, F. A. and Espin, J. C. (2005). Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: Identification of biomarkers and individual variability. J. Agric. Food Chem. 53:227–235.
   PubMed Web of Science ®Google Scholar
• Chen, C. Y. and Blumberg, J. B. (2008). Phytochemical composition of nuts. Asia Pacific J. Clinic. Nut. 17(Suppl. 1):329–332.
   PubMed Web of Science ®Google Scholar
• Colditz, G. A., Burdick, E. and Mosteller, F. (1995). Heterogeneity in meta-analysis of data from epidemiologic studies: A commentary. Am. J. Epidemiol. 142:371–382.
   PubMed Web of Science ®Google Scholar
• Colditz, G.A., Manson, J.E., and Hankinson, S.E. (1997). The Nurses' Health Study: 20-Year Contribution to the Understanding of Health Among Women. J Women's Health. 6(1): 49–62.
   Google Scholar
• Czernichow, S., Thomas, D. and Bruckert, E. (2010). n-6 Fatty acids and cardiovascular health: A review of the evidence for dietary intake recommendations. Br. J. Nutr. 104:1–9.
   PubMed Web of Science ®Google Scholar
• Daniel, E. M., Krupnick, A. S., Heur, Y. H., Blinzler, J. A., Nims, R. W. and Stoner, G. D. (1989). Extraction, stability, and quantitation of ellagic acid in various fruits and nuts. J. Food Comp. Anal. 2:338–349.
   Google Scholar
• Davis, P., Valacchi, G., Pagnin, E., Shao, Q., Gross, H. B., Calo, L. and Yokoyamaz, W. (2006). Walnuts reduce aortic ET-1 mRNA levels in hamsters fed a high-fat, atherogenic diet. J. Nutr. 136:428–432.
   PubMed Web of Science ®Google Scholar
• Davis, P. A., Vasua, V. T., Gohila, K., Kima, H., Khana, I. H., Carroll, E. and Yokoyama, W. (2012). A high-fat diet containing whole walnuts (Juglans regia) reduces tumour size and growth along with plasma insulin-like growth factor 1 in the transgenic adenocarcinoma of the mouse prostate model. Brit. J. Nutr. 108:1–9.
   Google Scholar
• Din, J. N., Aftab, S. M., Jubb, A. W., Carnegy, F. H. and Lyall, K. (2011). Effect of moderate walnut consumption on lipid profile, arterial stiffness and platelet activation in humans. Eur. J. Clin. Nutr. 65:234–239.
   PubMed Web of Science ®Google Scholar
• Doll, R. and Peto, R. (1981). The causes of cancer in the United States today. J. Nat. Cancer Inst. 66:1192–1308.
   Google Scholar
• Elmadfa, I. and Kornsteiner, M. (2009). Dietary fat intake – A global perspective. Ann. Nutr. Metab. 54(Suppl. 1):8–14.
   PubMed Web of Science ®Google Scholar
• Espin, J. C., Garcia-Conesa, M. T. and Tomas-Barberan, F. A. (2007). Nutraceuticals: Facts and fiction. Phytochemistry. 68:2896–3008.
   PubMed Web of Science ®Google Scholar
• Espin, J. C., Gonzalez-Barrio, R. and Cerda, B. (2007). Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans. J. Agric. Food Chem. 55:10476–10485.
   PubMed Web of Science ®Google Scholar
• Feldman, E. B. (2002). The scientific evidence for a beneficial health relationship between walnuts and coronary heart disease. J. Nutr. 132:1062S–1101S.
   PubMed Web of Science ®Google Scholar
• Ford, E. S., Williamson, D. F. and Liu, S. (1997). Weight change and diabetes incidence: Findings from a national cohort of US adults. Am. J. Epidemiol. 146:214–222.
   PubMed Web of Science ®Google Scholar
• Fukuda, T., Ito H. and Yoshida, T. (2003). Antioxidative polyphenols from walnuts (Juglans regia L.). Phytochemistry. 63:795–801.
   PubMed Web of Science ®Google Scholar
• Gao, X., Cassidy, A., Schwarzschild, M. A., Rimm, E. B. and Ascherio, A. (2012). Habitual intake of dietary flavonoids and risk of Parkinson's disease. Neurology. 78:1138–1145.
   PubMed Web of Science ®Google Scholar
• Gerber, M. (2009). Background review paper on total fat, fatty acid intake and cancers. Ann. Nutr. Metab. 55:140–161.
   PubMed Web of Science ®Google Scholar
• Gillen, L. S. and Tapsell, L. C. (2005). Structured dietary advice incorporating walnuts achieves optimal fat and energy balance in patients with type 2 diabetes mellitus. J. Am. Diet. Assoc. 105:1087–1096.
   PubMed Web of Science ®Google Scholar
• Gunduc, N. and El, S. N. (2003). Assessing antioxidant activities of phenolic compounds of common Turkish food and drinks on in vitro low-density lipoprotein oxidation. J. Food Sci. 68:2591–2595.
   Web of Science ®Google Scholar
• Hamazaki, T. and Okuyama, H. (2003). The Japan society for lipid nutrition recommends to reduce the intake of linolenic acid. A review and critique of the scientific evidence. In Omega-6/Omega-3 Essential Fatty Acid Ratio: The scientific evidence, volume eds. A P Simopoulos and L G Cleland. World Rev. Nutr. Diet. 92:109–132.
   PubMedGoogle Scholar
• Han, Y. S., Bastianetto, S., Dumont, Y. and Quirion, R. (2006). Specific plasma membrane binding sites for polyphenols, including resveratrol, in the rat brain. J. Pharmacol. Exp. Ther. 318:238–245.
   PubMed Web of Science ®Google Scholar
• Hardman, W. E. and Ion, G. (2008). Suppression of implanted MDA-MB 231 human breast cancer growth in nude mice by dietary walnut. Nutr. Cancer 60:666–674.
   PubMed Web of Science ®Google Scholar
• Hardman, W. E., Ion, G., Akinsete, J. A. and Witte, T. R. (2011). Dietary walnut suppressed mammary gland tumorigenesis in the C(3)1 TAg mouse. Nutr. Cancer. 63:960–970.
   PubMed Web of Science ®Google Scholar
• Harnly, J. M., Doherty, R. F., Beecher, G. R., Holden, J. M., Haytowitz, D. B., Bhagwat, S. and Gebhardt, S. (2006). Flavonoid content of US fruits, vegetables, and nuts. J. Agric. Food. Chem. 54:9966–9977.
   PubMed Web of Science ®Google Scholar
• Hu, F. B., Manson, J. E., Stampfer, M. J., Colditz, G., Liu, S., Solomon, C. G. and Willett, W. C. (2001). Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N. Engl. J. Med. 345:790–797.
   PubMed Web of Science ®Google Scholar
• Hu, F. B., Stampfer, M. J. and Rimm, E. (1999). Dietary fat and coronary heart disease. Am. J. Epidemiol. 149:531–540.
   PubMed Web of Science ®Google Scholar
• Huang, P., Chandra, V. and Rastinejad, F. (2010). Structural overview of the nuclear receptor superfamily: Insights into physiology and therapeutics. Ann. Rev. Physiol. 72:247–272.
   PubMed Web of Science ®Google Scholar
• International Nut and Dried Fruit Foundation. (2010). Nuts and Dried Fruits Global Statistical Review 2004–2009. INC, Reus, Spain.
   Google Scholar
• Ito, H. Okuda, T., Fukuda, T., Hatano, T. and Yoshida, T. (2007) Two novel dicarboxylic acid derivatives and a new dimeric hydrolysable tannin from walnuts. J. Agric. Food Chem. 55:672– 679.
   PubMed Web of Science ®Google Scholar
• Jiang, R., Manson, J. E., Stampfer, M. J., Liu, S., Willett, W. C. and Hu, F. B. (2002). Nut and peanut butter consumption and risk of type 2 diabetes in women. JAMA 288:2554–2560.
   PubMed Web of Science ®Google Scholar
• Jiang W., Oken H., Fiuzat M., Shaw, L.K., Martsberger, C., Kuchibhatla, M., Kaddurah-Daouk, R., Steffens, D.C., Baillie, R., Cuffe, M., Krishnan, R. and O’Connor, C. (2012). Plasma omega-3 polyunsaturated fatty acids and survival in patients with chronic heart failure and major depressive disorder. J Cardiovasc Transl Res. 5:92–99.
   PubMed Web of Science ®Google Scholar
• Joseph, J. A., Shukitt-Hale, B. and Willis, L. M. (2009). Grape juice, berries, and walnuts affect brain aging and behavior. J. Nutr. 139:1813S–1817S.
   PubMed Web of Science ®Google Scholar
• Kagawa, Y. (2001). In: Standard Tables of Food Composition in Japan. Kagawa Nutrition University Press, Tokyo, Japan.
   Google Scholar
• Kendall, C. W. C., Esfahani, A., Josse, A. R., Augustin, L. S. A., Vidgen, E. and Jenkins, D. J. A. (2011). The glycaemic effect of nut-enriched meals in healthy and diabetic subjects. Nutr. Metab. Cardiovasc. Dis. 21(Suppl. 1):S34–S39.
   Google Scholar
• Keys, A., Anderson, J. T. and Grande, F. (1957). Prediction of serum-cholesterol responses of man to changes in the diet. Lancet. 273:959–966.
   PubMedGoogle Scholar
• Knol, M. J., Twisk, J. W., Beekman, A. T., Heine, R. J., Snoek, F. J. and Pouwer, F. (2006). Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis. Diabetologia. 49:837–845.
   PubMed Web of Science ®Google Scholar
• Kolb, H. and Mandrup-Poulsen, T. (2005). An immune origin of type 2 diabetes? Diabetologia. 48:1038–1050.
   PubMed Web of Science ®Google Scholar
• Kolb, H. and Mandrup-Poulsen, T. (2010). The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation. Diabetologia. 53:10–20.
   PubMed Web of Science ®Google Scholar
• Kuo, P. T., Whereat, A. F., Bassett, D. R. and Ezra. (1961). Patterns of hyperlipaemic patients before and after the ingestion of different study of the mechanism of hyperlipaemia: Serum chylomicron fatty acid. Circulation. 24:213–222.
   PubMed Web of Science ®Google Scholar
• Labuckas, D. O., Maestri, D. M., Perello, M., Martinez, M. L. and Lamarque, A. L. (2008). Phenolics from walnut (Juglans regia L.) kernels: Antioxidant activity and interactions with proteins. Food Chem. 107:607–612.
   Web of Science ®Google Scholar
• Larsson, S. C., Kumlin, M., Ingelman-Sundberg, M. and Wolk, A. (2004). Dietary long-chain n-3 fatty acids for the prevention of cancer: A review of potential mechanisms. Am. J. Clin. Nutr. 79:935–945.
   PubMed Web of Science ®Google Scholar
• Li, L., Tsao, R., Yang, R., Kramer, J. and Hernandez, M. (2007). Fatty acid profiles, tocopherol contents, and antioxidant activities of heartnut (Juglans ailanthifolia var. cordiformis) and Persian walnut (Juglans regia L.). J. Agric. Food Chem. 55:1164–1169.
   PubMed Web of Science ®Google Scholar
• Maguire, L. S., O'sullivan, S. M., Galvin, K., O'Connor, T. P. and O'Brien, N. M. (2004). Fatty acid profile, tocopherol, squalene and phytosterol content of walnuts, almonds, peanuts, hazelnuts and the macadamia nut. J. Food Sci. Nutr. 55:171–178.
   PubMed Web of Science ®Google Scholar
• Manninen, V., Olli Elo, M., Heikki, F., Kauko, H., Heinonen, O., Heinsalmi, P., Helo, P., Huttunen, J. K., Kaitaniemi, P., Koskinen, P., Mäenpää, H., Mälkönen, M., Mänttäri, M., Norola, S., Pasternack, A., Pikkarainen, J., Romo, M., Sjöblom, T. and Nikkilä, E. A. (1988). Lipid alterations and decline in the incidence of coronary heart disease in the Helsinki Heart Study. J. Am. Med. Assoc. 260:641–651.
   PubMed Web of Science ®Google Scholar
• Mantzoros, C. S., Williams, C. J., Manson, J. E., Meigs, J. B. and Hu, F. B. (2006). Adherence to the Mediterranean dietary pattern is positively associated with plasma adiponectin concentrations in diabetic women. Am. J. Clin. Nutr. 84:328–335.
   PubMed Web of Science ®Google Scholar
• Martinez-Gonzalez, M. A., Corella, D., Salas-Salvado, J., Ros, E., Covas, M. I., Fiol, M., Warnberg, J., Aros, F., Ruiz-Gutierrez, V., Lamuela-Raventos, R. M., Lapetra, J., Munoz, M. A., Martinez, J. A., Saez, G., Serra-Majem, L., Pinto, X., Mitjavila, M. T., Tur, J. A., Portillo, M. D., Estruch, R. and the PREDIMED Study Investigators. (2010). Cohort profile: Design and methods of PREDIMED study. Int. J. Epidemiol. 41(2):377–385.
   Web of Science ®Google Scholar
• Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F. and Turner, R. C. (1985). Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28:412–419.
   PubMed Web of Science ®Google Scholar
• Mazza, M., Pomponi, M., Janiri, L., Bria, P. and Mazza, S. (2007). Omega-3 fatty acids and antioxidants in neurological and psychiatric diseases: An overview. Prog. Neuro.Psychopharmacol. Biol. Psych. 31:12–26.
   PubMed Web of Science ®Google Scholar
• Medina-Remon, A., Barrionuevo-Gonzalez, A., Zamora-Ros, R., Andres-Lacueva, C., Estruch, R., Martina-Gonzalez, M. A., Diez-Espino, J. and Lamuela-Raventos, R. M. (2009). Rapid Folin-Ciocalteu method using microtiter 96-well plate cartridges for solid phase extraction to assess urinary total phenolic compounds as a biomarker of total polyphenol intake. Anal. Chim. Acta 634: 54–60.
   PubMed Web of Science ®Google Scholar
• Mensink, R. P., Zock, P. L., Kester, A. D. and Katan, M. B. (2003). Effect of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: A meta-analysis of 60 controlled trials. Am. J. Clin. Nutr. 77:1146–1155.
   PubMed Web of Science ®Google Scholar
• Mente, A., de Koning, L., Shannon, H. S. and Anand, S. S. (2009). A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch. Intern. Med. 169:659–669.
   PubMed Web of Science ®Google Scholar
• Micha, R. and Mozaffarian, D. (2010). Saturated fat and cardiometabolic risk factors, coronary heart disease, stroke, and diabetes: A fresh look at the evidence. Lipids. 45:893–905.
   PubMed Web of Science ®Google Scholar
• Molendi-Coste, O., Legry, V. and Leclercq, I. A. (2011). Why and how meet n-3 PUFA Dietary Recommendations? Gastroenterol. Res. Pract. 2011:364.
   Google Scholar
• Nagel, J.M., Brinkoetter, M., Magkos, F., Liu, X., Chamberland, J.P., Shah, S., Zhou, J., Blackburn, G., and Mantzoros, C.S. (2012). Dietary walnuts inhibit colorectal cancer growth in mice by suppressing angiogenesis. Nutrition. 28:67–75.
   PubMed Web of Science ®Google Scholar
• Nagel, J.M., Brinkoetter, M., Magkos, F., Liu, X., Chamberland, J.P., Shah, S., Zhou, J., Blackburn, G. and Mantzoros, C.S. (2012). Dietary walnuts inhibit colorectal cancer growth in mice by suppressing angiogenesis. Nutrition. 28:67–75.
   PubMed Web of Science ®Google Scholar
• News Review. 2010. Lipid technology 5/2010. Lipid Technol. 22:99–102.
   Google Scholar
• Ohashia, K., Ouchia, N. and Matsuzawab, Y. (2012). Anti-inflammatory and anti-atherogenic properties of adiponectin. Biochimie. 94:21137–2142.
   Google Scholar
• Oshaghi1, E. A., Sorkhani, A. N. and Rezaei1, A. (2012). Effects of walnut on lipid profile as well as the expression of sterol-regulatory element binding protein-1c(SREBP-1c) and peroxisome proliferator activated receptors α (PPARα) in diabetic rat. Food Nutri. Sci. 3:255–259.
   Google Scholar
• Ouchi, N., Kobayashi, H., Kihara, S., Kumada, M., Sato, K., Inoue, T., Funahashi, T. and Walsh, K. (2004). Adiponectin stimulates angiogenesis by promoting cross-talk between AMP activated protein kinase and Akt signaling in endothelial cells. J. Biol. Chem. 279:1304–1309.
   PubMed Web of Science ®Google Scholar
• Papoutsi, Z., Kassi, E., Chinou, I., Halabalaki, M., Skaltsounis, L. A. and Moutsatsou, P. (2008). Walnut extract (Juglans regia L.) and its component ellagic acid exhibit anti-inflammatory activity in human aorta endothelial cells and osteoblastic activity in the cell line KS483. Br. J. Nutr. 99:715–722.
   PubMed Web of Science ®Google Scholar
• Park, E. J. and Pezzuto, J. M. (2012). Flavonoids in cancer prevention. Anticancer Agents Med. Chem. 12(8):836–851.
   PubMed Web of Science ®Google Scholar
• Pribis, P., Bailey, R. N., Russell, A. A., Kilsby, M. A., Hernandez, M., Craig, W. J., Grajales, T., Shavlik, D. J. and Sabate, J. (2012). Effects of walnut consumption on cognitive performance in young adults. Br. J. Nutr. 107:1393–1401.
   PubMed Web of Science ®Google Scholar
• Rey, A. (1964). L'examen Clinique en Psychologie. Presses Universitaires de France, Paris, France.
   Google Scholar
• Ros, E. (2009). Nuts and novel biomarkers of cardiovascular disease. Am. J. Clin. Nutr. 89:1649S–1656S.
   PubMed Web of Science ®Google Scholar
• Ros, E., Nunez, I., Perez-Heras, A., Serra, M., Gilabert, R. and Casals, E. (2004). A walnut diet improves endothelial function in hypercholesterolemic subjects: A randomized crossover trial. Circulation. 109:1609–1614.
   PubMed Web of Science ®Google Scholar
• Russo, G. L. (2009). Dietary n-6 and n-3 polyunsaturated fatty acids: From biochemistry to clinical implications in cardiovascular prevention. Biochem. Pharmacol. 77:937–946.
   PubMed Web of Science ®Google Scholar
• Sabate, J. (1993). Does nut consumption protest against ischemic heart disease? Eur. J. Clin. Nutr. 47:71–5S.
   Google Scholar
• Sabate, J., Cordero-Macintyre, Z., Siapco, G., Torabian, S. and Haddad, E. (2005). Does regular walnut consumption lead to weight gain? Br. J. Nutr. 94:859–864.
   PubMed Web of Science ®Google Scholar
• Salas-Salvado, J., Bullo, M., Babio, N., Martinez-Gonzalez, M., Ibarrola-Jurado, N., Basora, J., Estruch, R., Covas, M., Corella, D., Aros, F., Ruiz-Gutierrez, V. and Ros, E. (2011). Reduction in the incidence of type 2 diabetes with the mediterranean diet. Diabetes Care. 34:14–19.
   PubMed Web of Science ®Google Scholar
• Shakibaei, M., Harikumar, K. B. and Aggarwal, B. B. (2009). Resveratrol addiction: To die or not to die. Mol. Nutr. Food Res. 53:115–128.
   PubMed Web of Science ®Google Scholar
• Shaw, J. E, Sicree, R. A. and Zimmet, P. Z. (2010). Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res. Clin. Pract. 87:4–14.
   PubMed Web of Science ®Google Scholar
• Shu, H., Wong, B., Zhou, G., Li, Y., Berger, J., Woods, J. W., Wright, S. D. and Cai, T. Q. (2000). Activation of PPARα or γ reduces secretion of matrix metalloproteinase 9 but not interleukin 8 from human monocytic THP-1 cells. Biochem. Biophys. Res. Commun. 267:345–349.
   PubMed Web of Science ®Google Scholar
• Simon, J. A., Chen, Y. H. and Bent, S. (2009). The relation of a-linolenic acid to the risk of prostate cancer: A systematic review and meta-analysis. Am. J. Clin. Nutr. 89(Suppl):1558S–1596S.
   Google Scholar
• Simopoulos, A. P. (2008). The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp. Biol. Med. 233:674–688.
   PubMed Web of Science ®Google Scholar
• Singh, P., Kumar, A., Dubey, N. K. and Gupta, R. (2009). Essential oil of Aegle marmelos as a safe plant-based antimicrobial against postharvest microbial infestations and aflatoxin contamination of food commodities. J. Food Sci. 74:302–307.
   PubMed Web of Science ®Google Scholar
• Singleton, V. L., Orthofer, R. and Lamuela-Raventos, R. M. (1999). Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol. 299:152–178.
   Web of Science ®Google Scholar
• Siri-Tarino, P. W, Sun, Q., Hu, F. B. and Krauss, R. M. (2010). Saturated fat, carbohydrate, and cardiovascular disease. Am. J. Clin. Nutr. 91:502–509.
   PubMed Web of Science ®Google Scholar
• Smoliga, J. M., Baur, J. A., and Hausenblas, H. A. (2011). Resveratrol and health – A comprehensive review of human clinical trials. Mol. Nutr. Food Res. 55:1129–1141.
   PubMed Web of Science ®Google Scholar
• Spaccarotella, K. J., Kris-Etherton, P. M., Stone, W. L., Bagshaw, D. M., Fishell, V. K., West, S. G., Lawrence, F. R. and Hartman, T. J. (2008). The effect of walnut intake on factors related to prostate and vascular health in older men. Nutr. J. 2:7–13.
   Google Scholar
• Spranger, J., Mohlig, M., Wegewitz, U., Ristow, M., Pfeiffer, A. F., Schill, T., Schlosser, H.W. Brabant, G. and Schofl, C. (2004). Adiponectin is independently associated with insulin sensitivity in women with polycystic ovary syndrome. Clin. Endocrinol. 61:738–746.
   PubMed Web of Science ®Google Scholar
• Steppan, C. M., Bailey, S. T., Bhat, S. S., Brown, E.J., Banerjee, R.R., Wright,C.M., Hiralben R. Patel, Ahima R.S. and Lazar, M.A. (2001). The hormone resistin links obesity to diabetes. Nature. 409:307–312.
   PubMed Web of Science ®Google Scholar
• Stoner, G. D. and Mukhtar, H. (1995). Polyphenols as cancer chemopreventive agents. J. Cell Biochem. Suppl. 22:169–180.
   PubMedGoogle Scholar
• Sze-Tao, K. W., Schrimpf, J. E., Teuber, S. S., Roux, K. H. and Sathe, S. K. (2001). Effects of processing and storage on walnut (Juglans regia L.) tannins. J. Sci. Food Agric. 81:1215–1222.
   Web of Science ®Google Scholar
• Tapsell, L. C., Gillen, L. J., Patch, C. S., Batterham, M., Owen, A., Baré, M. and Kennedy, M. (2004). Including walnuts in a low-fat/modified-fat diet improves HDL cholesterol-to-total cholesterol ratios in patients with type 2 diabetes. Diabetes Care. 27:2777–2783.
   PubMed Web of Science ®Google Scholar
• Torabian, S., Haddad, E., Cordero-Macintyre, Z., Tanzman, J., Fernandez, M. L. and Sabate, J. (2010). Long-term walnut supplementation without dietary advice induces favorable serum lipid changes in free-living individuals. Eur. J. Clin. Nutr. 64:274.
   PubMed Web of Science ®Google Scholar
• Umesalma, S. and Sudhandiran, G. (2011). Ellagic acid prevents rat colon carcinogenesis induced by 1, 2 dimethyl hydrazine through inhibition of AKT-phosphoinositide-3 kinase pathway. Eur. J. Pharmacol. 660:249–258.
   PubMed Web of Science ®Google Scholar
• U.S. Department of Agriculture Nutrient Data Base at http://ndb.nal.usda.gov/ndb/search Accessed 2012.
   Google Scholar
• Valls-Pedret, C., Lamuela-Raventos, R. S., Medina-Remon, A., Quintana, M., Dolores, C., Pinto, X., Martinez-Gonzalez, M. A., Estruch, R. and Ros, E. (2012). Polyphenol-rich foods in the Mediterranean diet are associated with better cognitive function in elderly subjects at high cardiovascular risk. J. Alzheimer's Dis. 29:773–782.
   PubMed Web of Science ®Google Scholar
• Vinson, J. A. and Cai, Y. (2011). Nuts, especially walnuts, have both antioxidant quantity and efficacy and exhibit significant potential health benefits. Food Funct. 3:134–140.
   PubMed Web of Science ®Google Scholar
• Vinson, J. A. and Honz, B. A. (1995). Phenol antioxidant index: Comparative antioxidant effectiveness of red and white wines. J. Agric Food Chem. 43:401–403.
   Web of Science ®Google Scholar
• Visioli, F., Lastra, C. A. and Andres-Lacueva, C. (2011). Polyphenols and human health: A prospectus. Crit. Rev. Food Sci. Nutr. 51:524–546.
   PubMed Web of Science ®Google Scholar
• Willett, W. C. (2012). Dietary fats and coronary heart disease. J. Int. Med. 272:13–24.
   PubMed Web of Science ®Google Scholar
• Williams, C. D., Whitley, B. M., Hoyo, C., Grant, D. J., Iraggi, J. D., Newman, K. A., Gerber, L., Taylor, L. A., McKeever, M. G. and Freedland, S. J. (2011). A high ratio of dietary n-6/n-3 polyunsaturated fatty acids is associated with increased risk of prostate cancer. Nutr. Res. 31:1–8.
   PubMed Web of Science ®Google Scholar
• Willis, L. M., Shukitt-Hale, B., Cheng, V. and Joseph, J. A. (2009). Dose-dependent effects of walnuts on motor and cognitive function in aged rats. British J. Nutr. 101, 1140–1144.
   PubMed Web of Science ®Google Scholar
• Wood, A. W., Huang, M. T., Chang, R. L., Newmark, H. L., Lehr, R. E., Yagi, H., Sayer, J. M., Jerina, D. M. and Conney, A. H. (1982). Inhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols exceptional activity of ellagic acid. Proc. Nat. Acad Sci. 79:5513–5517.
   PubMed Web of Science ®Google Scholar
• Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., Ezaki, O., Akanuma, Y., Gavrilova, O., Vinson, C., Reitman, M. L., Kagechika, H., Shudo, K., Yoda, M., Nakano, Y., Tobe, K., Nagai, R., Kimura, S., Tomita, M., Froguel, P. and Kadowaki, T. (2001). The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7:941–946.
   PubMed Web of Science ®Google Scholar
• Ziemke, F. and Mantzoros, C. S. (2010). Adiponectin in insulin resistance: Lessons from translational research. Am. J. Clin. Nutr. 91(Suppl.):258S–261S.
   PubMed Web of Science ®Google Scholar