The Role of Nutrients in Protecting Mitochondrial Function and Neurotransmitter Signaling: Implications for the Treatment of Depression, PTSD, and Suicidal Behaviors

REFERENCES

• Allen, J. A., Halverson-Tamboli, R. A. and Rasenick, M. M. (2007). Lipid raft microdomains and neurotransmitter signalling. Nat. Rev. Neurosci. 8:128–140.
   PubMed Web of Science ®Google Scholar
• Almeida, O. P., Lautenschlager, N., Flicker, L., Leedman, P., Vasikaran, S., Gelavis, A. and Ludlow, J. (2004). Association between homocysteine, depression, and cognitive function in community-dwelling older women from Australia. J. Am. Geriatr. Soc. 52:327–328.
   PubMed Web of Science ®Google Scholar
• Almeida, O. P., McCaul, K., Hankey, G. J., Norman, P., Jamrozik, K. and Flicker, L. (2008). Homocysteine and depression in later life. Arch. Gen. Psychiatry. 65:1286–1294.
   PubMed Web of Science ®Google Scholar
• Alpert, J. E., Mischoulon, D., Rubenstein, G. E., Bottonari, K., Nierenberg, A. A. and Fava, M. (2002). Folinic acid (Leucovorin) as an adjunctive treatment for SSRI-refractory depression. Ann. Clin. Psychiatry. 14:33–38.
   PubMedGoogle Scholar
• Amr, M., El-Mogy, A., Shams, T., Vieira, K. and Lakhan, S. E. (2013). Efficacy of vitamin C as an adjunct to fluoxetine therapy in pediatric major depressive disorder: A randomized, double-blind, placebo-controlled pilot study. Nutr J. 12:31.
   PubMed Web of Science ®Google Scholar
• Arts, M. J., Grun, C., de Jong, R. L., Voss, H. P., Bast, A., Mueller, M. J. and Haenen, G. R. (2007). Oxidative degradation of lipids during mashing. J. Agric. Food Chem. 55:7010–7014.
   PubMed Web of Science ®Google Scholar
• Atmaca, M., Kuloglu, M., Tezcan, E., Ustundag, B., Gecici, O. and Firidin, B. (2002). Serum leptin and cholesterol values in suicide attempters. Neuropsychobiology. 45:124–127.
   PubMed Web of Science ®Google Scholar
• Bao, A. M., Meynen, G. and Swaab, D. F. (2008). The stress system in depression and neurodegeneration: Focus on the human hypothalamus. Brain Res. Rev. 57:531–553.
   PubMed Web of Science ®Google Scholar
• Barragan-Rodriguez, L., Rodriguez-Moran, M. and Guerrero-Romero, F. (2008). Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: A randomized, equivalent trial. Magnes. Res. 21:218–223.
   PubMed Web of Science ®Google Scholar
• Ben-Shachar, D. and Laifenfeld, D. (2004). Mitochondria, synaptic plasticity, and schizophrenia. Int. Rev. Neurobiol. 59:273–296.
   PubMed Web of Science ®Google Scholar
• Berk, M., Copolov, D. L., Dean, O., Lu, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M. and Bush, A. I. (2008). N-acetyl cysteine for depressive symptoms in bipolar disorder—a double-blind randomized placebo-controlled trial. Biol. Psychiatry. 64:468–475.
   PubMed Web of Science ®Google Scholar
• Bilici, M., Efe, H., Koroglu, M. A., Uydu, H. A., Bekaroglu, M. and Deger, O. (2001). Antioxidative enzyme activities and lipid peroxidation in major depression: Alterations by antidepressant treatments. J. Affect. Disord. 64:43–51.
   PubMed Web of Science ®Google Scholar
• Black, P. H. and Garbutt, L. D. (2002). Stress, inflammation and cardiovascular disease. J. Psychosom. Res. 52:1–23.
   PubMed Web of Science ®Google Scholar
• Boston, P. F., Dursun, S. M. and Reveley, M. A. (1996). Cholesterol and mental disorder. Br. J. Psychiatry. 169:682–689.
   PubMed Web of Science ®Google Scholar
• Bourin, M., David, D. J., Jolliet, P. and Gardier, A. (2002). [Mechanism of action of antidepressants and therapeutic perspectives]. Therapie. 57:385–396.
   PubMed Web of Science ®Google Scholar
• Bourre, J. M. (2004). The role of nutritional factors on the structure and function of the brain: An update on dietary requirements. Rev. Neurol. (Paris). 160:767–792.
   PubMed Web of Science ®Google Scholar
• Bourre, J. M., Francois, M., Youyou, A., Dumont, O., Piciotti, M., Pascal, G. and Durand, G. (1989). The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. J. Nutr. 119:1880–1892.
   PubMed Web of Science ®Google Scholar
• Brambilla, P., Perez, J., Barale, F., Schettini, G. and Soares, J. C. (2003). GABAergic dysfunction in mood disorders. Mol. Psychiatry. 8:721–737, 715.
   PubMed Web of Science ®Google Scholar
• Brenner-Lavie, H., Klein, E. and Ben-Shachar, D. (2009). Mitochondrial complex I as a novel target for intraneuronal DA: Modulation of respiration in intact cells. Biochem. Pharmacol. 78:85–95.
   PubMed Web of Science ®Google Scholar
• Brody, S. (2002). High-dose ascorbic acid increases intercourse frequency and improves mood: A randomized controlled clinical trial. Biol. Psychiatry. 52:371–374.
   PubMed Web of Science ®Google Scholar
• Brown, A. S. and Gershon, S. (1993). Dopamine and depression. J. Neural. Transm. Gen. Sect. 91:75–109.
   PubMed Web of Science ®Google Scholar
• Brunner, J., Parhofer, K. G., Schwandt, P. and Bronisch, T. (2001). Cholesterol, omega-3 fatty acids, and suicide risk: Empirical evidence and pathophysiological hypotheses. Fortschr. Neurol. Psychiatr. 69:460–467.
   PubMed Web of Science ®Google Scholar
• Brunner, J., Parhofer, K. G., Schwandt, P. and Bronisch, T. (2002). Cholesterol, essential fatty acids, and suicide. Pharmacopsychiatry. 35:1–5.
   PubMed Web of Science ®Google Scholar
• Bryan, C. J., Cukrowicz, K. C., West, C. L. and Morrow, C. E. (2010). Combat experience and the acquired capability for suicide. J. Clin. Psychol. 66:1044–1056.
   PubMed Web of Science ®Google Scholar
• Cadeddu, G., Fioravanti, P., Antonicelli, R., Gasparrini, P. M. and Gaetti, R. (1995). Relationship between cholesterol levels and depression in the elderly. Minerva Med. 86:251–256.
   PubMedGoogle Scholar
• Calabrese, V., Cornelius, C., Mancuso, C., Lentile, R., Stella, A. M. and Butterfield, D. A. (2010). Redox homeostasis and cellular stress response in aging and neurodegeneration. Methods Mol. Biol. 610:285–308.
   PubMedGoogle Scholar
• Chang, Y., Liu, Y. P. and Liu, C. F. (2009). The effect on serotonin and MDA levels in depressed patients with insomnia when far-infrared rays are applied to acupoints. Am. J. Chin. Med. 37:837–842.
   PubMed Web of Science ®Google Scholar
• Charney, D. S. and Manji, H. K. (2004). Life stress, genes, and depression: Multiple pathways lead to increased risk and new opportunities for intervention. Sci. STKE. 2004:re5.
   PubMedGoogle Scholar
• Clayton, E. H., Hanstock, T. L., Hirneth, S. J., Kable, C. J., Garg, M. L. and Hazell, P. L. (2009). Reduced mania and depression in juvenile bipolar disorder associated with long-chain omega-3 polyunsaturated fatty acid supplementation. Eur. J. Clin. Nutr. 63:1037–1040.
   PubMed Web of Science ®Google Scholar
• Cocchi, P., Silenzi, M., et al. (1980). Antidepressant effect of vitamin C. Pediatrics. 65(4):862–863.
   PubMed Web of Science ®Google Scholar
• Colin, A., Reggers, J., Castronovo, V. and Ansseau, M. (2003). Lipids, depression and suicide. Encephale. 29:49–58.
   PubMed Web of Science ®Google Scholar
• Cook, S. C. and Wellman, C. L. (2004). Chronic stress alters dendritic morphology in rat medial prefrontal cortex. J. Neurobiol. 60:236–248.
   PubMed Web of Science ®Google Scholar
• Coppen, A. and Bailey, J. (2000). Enhancement of the antidepressant action of fluoxetine by folic acid: A randomised, placebo controlled trial. J. Affect. Disord. 60:121–130.
   PubMed Web of Science ®Google Scholar
• Coppen, A. and Bolander-Gouaille, C. (2005). Treatment of depression: Time to consider folic acid and vitamin B12. J. Psychopharmacol. 19:59–65.
   PubMed Web of Science ®Google Scholar
• Corniola, R. S., Tassabehji, N. M., Hare, J., Sharma, G. and Levenson, C. W. (2008). Zinc deficiency impairs neuronal precursor cell proliferation and induces apoptosis via p53-mediated mechanisms. Brain Res. 1237:52–61.
   PubMed Web of Science ®Google Scholar
• Covington, H. E., 3rd, Maze, I., LaPlant, Q. C., Vialou, V. F., Ohnishi, Y. N., Berton, O., Fass, D. M., Renthal, W., Rush, A. J., 3rd, Wu, E. Y., Ghose, S., Krishnan, V., Russo, S. J., Tamminga, C., Haggarty, S. J. and Nestler, E. J. (2009). Antidepressant actions of histone deacetylase inhibitors. J. Neurosci. 29:11451–11460.
   PubMed Web of Science ®Google Scholar
• Cumurcu, B. E., Ozyurt, H., Etikan, I., Demir, S. and Karlidag, R. (2009). Total antioxidant capacity and total oxidant status in patients with major depression: Impact of antidepressant treatment. Psychiatry Clin. Neurosci. 63:639–645.
   PubMed Web of Science ®Google Scholar
• Czysz, A. H. and Rasenick, M. M. (2013). G-protein signaling, lipid rafts and the possible sites of action for the antidepressant effects of n-3 polyunsaturated fatty acids. CNS Neurol. Disord. Drug Targets. 12:466–473.
   PubMed Web of Science ®Google Scholar
• Czeh, B. and Simon, M. (2005). Neuroplasticity and depression. Psychiatr. Hung. 20:4–17.
   PubMedGoogle Scholar
• de Souza, F. G., Rodrigues, M. D., Tufik, S., Nobrega, J. N. and D'Almeida, V. (2006). Acute stressor-selective effects on homocysteine metabolism and oxidative stress parameters in female rats. Pharmacol. Biochem. Behav. 85:400–407.
   PubMed Web of Science ®Google Scholar
• Delibas, N., Altuntas, I., Sutcu, R., Yonden, Z. and Koylu, H. (2004). Effects of dietary long chain PUFAs on hippocampal lipid peroxidation and NMDA receptor subunits A and B concentration in streptozotocin-diabetic rats. Int. J. Neurosci. 114:1353–1364.
   PubMed Web of Science ®Google Scholar
• Dohrenwend, B. P. (2006). Inventorying stressful life events as risk factors for psychopathology: Toward resolution of the problem of intracategory variability. Psychol. Bull. 132:477–495.
   PubMed Web of Science ®Google Scholar
• Donati, R. J., Dwivedi, Y., Roberts, R. C., Conley, R. R., Pandey, G. N. and Rasenick, M. M. (2008). Postmortem brain tissue of depressed suicides reveals increased Gs alpha localization in lipid raft domains where it is less likely to activate adenylyl cyclase. J. Neurosci. 28:3042–3050.
   PubMed Web of Science ®Google Scholar
• Drevets, W. C. (2000). Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression. Prog. Brain. Res. 126:413–431.
   PubMed Web of Science ®Google Scholar
• Du, J., Creson, T. K., Wu, L. J., Ren, M., Gray, N. A., Falke, C., Wei, Y., Wang, Y., Blumenthal, R., Machado-Vieira, R., Yuan, P., Chen, G., Zhuo, M. and Manji, H. K. (2008). The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior. J. Neurosci. 28:68–79.
   PubMed Web of Science ®Google Scholar
• Du, J., Gray, N. A., Falke, C. A., Chen, W., Yuan, P., Szabo, S. T., Einat, H. and Manji, H. K. (2004). Modulation of synaptic plasticity by antimanic agents: The role of AMPA glutamate receptor subunit 1 synaptic expression. J. Neurosci. 24:6578–6589.
   PubMed Web of Science ®Google Scholar
• Du, J., Gray, N. A., Falke, C., Yuan, P., Szabo, S. and Manji, H. K. (2003). Structurally dissimilar antimanic agents modulate synaptic plasticity by regulating AMPA glutamate receptor subunit GluR1 synaptic expression. Ann. N. Y. Acad. Sci. 1003:378–380.
   PubMed Web of Science ®Google Scholar
• Du, J., Suzuki, K., Wei, Y., Wang, Y., Blumenthal, R., Chen, Z., Falke, C., Zarate, C. A., Jr. and Manji, H. K. (2007). The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: Relationship to clinical effects in mood disorders. Neuropsychopharmacology. 32:793–802.
   PubMed Web of Science ®Google Scholar
• Du, J., Wang, Y., Hunter, R., Wei, Y., Blumenthal, R., Falke, C., Khairova, R., Zhou, R., Yuan, P., Machado-Vieira, R., McEwen, B. S. and Manji, H. K. (2009). Dynamic regulation of mitochondrial function by glucocorticoids. Proc. Natl. Acad. Sci. U S A. 106:3543–3548.
   PubMed Web of Science ®Google Scholar
• Dwivedi, Y. (2009). Brain-derived neurotrophic factor: Role in depression and suicide. Neuropsychiatr. Dis. Treat. 5:433–449.
   PubMed Web of Science ®Google Scholar
• Eby, G. A. and Eby, K. L. (2006). Rapid recovery from major depression using magnesium treatment. Med. Hypotheses. 67:362–370.
   PubMed Web of Science ®Google Scholar
• Eby, G. A., 3rd and Eby, K. L. (2010). Magnesium for treatment-resistant depression: A review and hypothesis. Med. Hypotheses. 74:649–660.
   PubMed Web of Science ®Google Scholar
• Edwards, R., Peet, M., Shay, J. and Horrobin, D. (1998). Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. J. Affect. Disord. 48:149–155.
   PubMed Web of Science ®Google Scholar
• Engstrom, K., Saldeen, A. S., Yang, B., Mehta, J. L. and Saldeen, T. (2009). Effect of fish oils containing different amounts of EPA, DHA, and antioxidants on plasma and brain fatty acids and brain nitric oxide synthase activity in rats. Ups. J. Med. Sci. 114:206–213.
   PubMed Web of Science ®Google Scholar
• Enya, M., Kanoh, Y., Mune, T., Ishizawa, M., Sarui, H., Yamamoto, M., Takeda, N., Yasuda, K., Yasujima, M., Tsutaya, S. and Takeda, J. (2004). Depressive state and paresthesia dramatically improved by intravenous MgSO4 in Gitelman's syndrome. Intern. Med. 43:410–414.
   PubMed Web of Science ®Google Scholar
• Epel, E. S. (2009). Psychological and metabolic stress: A recipe for accelerated cellular aging?. Hormones (Athens). 8:7–22.
   PubMedGoogle Scholar
• Everson, C. A., Laatsch, C. D. and Hogg, N. (2005). Antioxidant defense responses to sleep loss and sleep recovery. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288:R374–R383.
   PubMed Web of Science ®Google Scholar
• Fang, B. J., Tonelli, L. H., Soriano, J. J. and Postolache, T. T. (2010). Disturbed sleep: Linking allergic rhinitis, mood and suicidal behavior. Front Biosci. (Schol. Ed). 2:30–46.
   PubMedGoogle Scholar
• Ferrer, I. (2009). Altered mitochondria, energy metabolism, voltage-dependent anion channel, and lipid rafts converge to exhaust neurons in Alzheimer's disease. J. Bioenerg. Biomembr. 41:425–431.
   PubMed Web of Science ®Google Scholar
• Folstein, M., Liu, T., Peter, I., Buell, J., Arsenault, L., Scott, T. and Qiu, W. W. (2007). The homocysteine hypothesis of depression. Am. J. Psychiatry. 164:861–867.
   PubMed Web of Science ®Google Scholar
• Francesconi, A., Kumari, R. and Zukin, R. S. (2009). Regulation of group I metabotropic glutamate receptor trafficking and signaling by the caveolar/lipid raft pathway. J. Neurosci. 29:3590–3602.
   PubMed Web of Science ®Google Scholar
• Frank, B. and Gupta, S. (2005). A review of antioxidants and Alzheimer's disease. Ann. Clin. Psychiatry. 17:269–286.
   PubMedGoogle Scholar
• Freeman, M. P., Davis, M., Sinha, P., Wisner, K. L., Hibbeln, J. R. and Gelenberg, A. J. (2008). Omega-3 fatty acids and supportive psychotherapy for perinatal depression: A randomized placebo-controlled study. J. Affect. Disord. 110:142–148.
   PubMed Web of Science ®Google Scholar
• Galecki, P., Szemraj, J., Bienkiewicz, M., Zboralski, K. and Galecka, E. (2009). Oxidative stress parameters after combined fluoxetine and acetylsalicylic acid therapy in depressive patients. Hum. Psychopharmacol. 24:277–286.
   PubMed Web of Science ®Google Scholar
• Godfrey, P. S., Toone, B. K., Carney, M. W., Flynn, T. G., Bottiglieri, T., Laundy, M., Chanarin, I. and Reynolds, E. H. (1990). Enhancement of recovery from psychiatric illness by methylfolate. Lancet. 336:392–395.
   PubMed Web of Science ®Google Scholar
• Grenyer, B. F., Crowe, T., Meyer, B., Owen, A. J., Grigonis-Deane, E. M., Caputi, P. and Howe, P. R. (2007). Fish oil supplementation in the treatment of major depression: A randomised double-blind placebo-controlled trial. Prog. Neuropsychopharmacol. Biol. Psychiatry. 31:1393–1396.
   PubMed Web of Science ®Google Scholar
• Hallahan, B., Hibbeln, J. R., Davis, J. M. and Garland, M. R. (2007). Omega-3 fatty acid supplementation in patients with recurrent self-harm. Single-centre double-blind randomised controlled trial. Br. J. Psychiatry. 190:118–122.
   PubMed Web of Science ®Google Scholar
• Hibbeln, J. R. and Salem, N., Jr. (1995). Dietary polyunsaturated fatty acids and depression: When cholesterol does not satisfy. Am. J. Clin. Nutr. 62:1–9.
   PubMed Web of Science ®Google Scholar
• Hirayama, T. (1990). A large scale cohort study on the effect of life styles on the risk of cancer by each site. Gan No Rinsho. 1990 Feb; Spec No: 233–242. [Japanese].
   PubMedGoogle Scholar
• Hooijmans, C. R., Van der Zee, C. E., Dederen, P. J., Brouwer, K. M., Reijmer, Y. D., van Groen, T., Broersen, L. M., Lutjohann, D., Heerschap, A. and Kiliaan, A. J. (2009). DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice. Neurobiol. Dis. 33:482–498.
   PubMed Web of Science ®Google Scholar
• Horsten, M., Wamala, S. P., Vingerhoets, A. and Orth-Gomer, K. (1997). Depressive symptoms, social support, and lipid profile in healthy middle-aged women. Psychosom. Med. 59:521–528.
   PubMed Web of Science ®Google Scholar
• Huan, M., Hamazaki, K., Sun, Y., Itomura, M., Liu, H., Kang, W., Watanabe, S., Terasawa, K. and Hamazaki, T. (2004). Suicide attempt and n-3 fatty acid levels in red blood cells: A case control study in China. Biol. Psychiatry. 56:490–496.
   PubMed Web of Science ®Google Scholar
• Irie, M., Asami, S., Ikeda, M. and Kasai, H. (2003). Depressive state relates to female oxidative DNA damage via neutrophil activation. Biochem. Biophys. Res. Commun. 311:1014–1018.
   PubMed Web of Science ®Google Scholar
• Irie, M., Miyata, M. and Kasai, H. (2005). Depression and possible cancer risk due to oxidative DNA damage. J. Psychiatr. Res. 39:553–560.
   PubMed Web of Science ®Google Scholar
• Irmisch, G., Schlaefke, D. and Richter, J. (2010). Zinc and fatty acids in depression. Neurochem. Res. 35:1376–1383.
   PubMed Web of Science ®Google Scholar
• Jazayeri, S., Tehrani-Doost, M., Keshavarz, S. A., Hosseini, M., Djazayery, A., Amini, H., Jalali, M. and Peet, M. (2008). Comparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic acid and fluoxetine, separately and in combination, in major depressive disorder. Aust. N. Z. J. Psychiatry. 42:192–198.
   PubMed Web of Science ®Google Scholar
• Jou, S. H., Chiu, N. Y. and Liu, C. S. (2009). Mitochondrial dysfunction and psychiatric disorders. Chang Gung. Med. J. 32:370–379.
   PubMedGoogle Scholar
• Kessler, R. C. (2000). Posttraumatic stress disorder: The burden to the individual and to society. J. Clin. Psychiatry. 61(Suppl 5):4–12; discussion 13–14.
   PubMed Web of Science ®Google Scholar
• Khanzode, S. D., Dakhale, G. N., Khanzode, S. S., Saoji, A. and Palasodkar, R. (2003a). Oxidative damage and major depression: The potential antioxidant action of selective serotonin re-uptake inhibitors. Redox. Rep. 8:365–370.
   PubMed Web of Science ®Google Scholar
• Khanzode, S. S., Khanzode, S. D. and Dakhale, G. N. (2003b). Serum and plasma concentration of oxidant and antioxidants in patients of Helicobacter pylori gastritis and its correlation with gastric cancer. Cancer Lett. 195:27–31.
   PubMed Web of Science ®Google Scholar
• Kim, Y. K., Lee, H. J., Kim, J. Y., Yoon, D. K., Choi, S. H. and Lee, M. S. (2002). Low serum cholesterol is correlated to suicidality in a Korean sample. Acta Psychiatr. Scand. 105:141–148.
   PubMed Web of Science ®Google Scholar
• Kodas, E., Vancassel, S., Lejeune, B., Guilloteau, D. and Chalon, S. (2002). Reversibility of n-3 fatty acid deficiency-induced changes in dopaminergic neurotransmission in rats: Critical role of developmental stage. J. Lipid Res. 43:1209–1219.
   PubMed Web of Science ®Google Scholar
• Kunugi, H. (2001). Low serum cholesterol and suicidal behavior. Nippon. Rinsho. 59:1599–1604.
   PubMedGoogle Scholar
• Kunugi, H., Takei, N., Aoki, H. and Nanko, S. (1997). Low serum cholesterol in suicide attempters. Biol. Psychiatry. 41:196–200.
   PubMed Web of Science ®Google Scholar
• Lalovic, A., Levy, E., Luheshi, G., Canetti, L., Grenier, E., Sequeira, A. and Turecki, G. (2007). Cholesterol content in brains of suicide completers. Int. J. Neuropsychopharmacol. 10:159–166.
   PubMed Web of Science ®Google Scholar
• Lalovic, A., Merkens, L., Russell, L., Arsenault-Lapierre, G., Nowaczyk, M. J., Porter, F. D., Steiner, R. D. and Turecki, G. (2004). Cholesterol metabolism and suicidality in Smith–Lemli–Opitz syndrome carriers. Am. J. Psychiatry. 161:2123–2126.
   PubMed Web of Science ®Google Scholar
• Lapierre, C. B. (2008). Deployment with combat exposure increases the risk of new-onset PTSD. Evid. Based Ment. Health. 11:126.
   PubMedGoogle Scholar
• Lapierre, C. B., Schwegler, A. F. and Labauve, B. J. (2007). Posttraumatic stress and depression symptoms in soldiers returning from combat operations in Iraq and Afghanistan. J. Trauma Stress. 20:933–943.
   PubMed Web of Science ®Google Scholar
• Lavie, L. (2009). Oxidative stress–a unifying paradigm in obstructive sleep apnea and comorbidities. Prog. Cardiovasc. Dis. 51:303–312.
   PubMed Web of Science ®Google Scholar
• Lekman, M., Paddock, S. and McMahon, F. J. (2008). Pharmacogenetics of major depression: Insights from level 1 of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. Mol. Diagn. Ther. 12:321–330.
   PubMed Web of Science ®Google Scholar
• Lester, D. (2002). Serum cholesterol levels and suicide: A meta-analysis. Suicide Life Threat. Behav. 32:333–346.
   PubMed Web of Science ®Google Scholar
• Li, Y. and Zhang, J. (2007). Serum concentrations of antioxidant vitamins and carotenoids are low in individuals with a history of attempted suicide. Nutr. Neurosci. 10:51–58.
   PubMed Web of Science ®Google Scholar
• Lindberg, G., Larsson, G., Setterlind, S. and Rastam, L. (1994). Serum lipids and mood in working men and women in Sweden. J. Epidemiol. Community Health. 48:360–363.
   PubMed Web of Science ®Google Scholar
• Lindberg, G., Rastam, L., Gullberg, B. and Eklund, G. A. (1992). Low serum cholesterol concentration and short term mortality from injuries in men and women. Bmj. 305:277–279.
   PubMed Web of Science ®Google Scholar
• Lineberry, T. W. (2009). Suicide rates in 2009. Do the economy and wars have an effect? Minn. Med. 92:49–52.
   PubMedGoogle Scholar
• Madrigal, J. L., Olivenza, R., Moro, M. A., Lizasoain, I., Lorenzo, P., Rodrigo, J. and Leza, J. C. (2001). Glutathione depletion, lipid peroxidation and mitochondrial dysfunction are induced by chronic stress in rat brain. Neuropsychopharmacology. 24:420–429.
   PubMed Web of Science ®Google Scholar
• Maes, M., Christophe, A., Delanghe, J., Altamura, C., Neels, H. and Meltzer, H. Y. (1999). Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients. Psychiatry Res. 85:275–291.
   PubMed Web of Science ®Google Scholar
• Maes, M., Delanghe, J., Meltzer, H. Y., Scharpe, S., D'Hondt, P. and Cosyns, P. (1994). Lower degree of esterification of serum cholesterol in depression: Relevance for depression and suicide research. Acta Psychiatr. Scand. 90:252–258.
   PubMed Web of Science ®Google Scholar
• Maes, M., Galecki, P., Chang, Y. S. and Berk, M. (2011). A review on the oxidative and nitrosative stress (O and NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness. Prog. Neuropsychopharmacol. Biol. Psychiatry. 35(3):676–692.
   PubMed Web of Science ®Google Scholar
• Maes, M., Mihaylova, I., Kubera, M., Uytterhoeven, M., Vrydags, N. and Bosmans, E. (2009a). Lower plasma Coenzyme Q10 in depression: A marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness. Neuro. Endocrinol. Lett. 30:462–469.
   PubMed Web of Science ®Google Scholar
• Maes, M., Smith, R., Christophe, A., Vandoolaeghe, E., Van Gastel, A., Neels, H., Demedts, P., Wauters, A. and Meltzer, H. Y. (1997a). Lower serum high-density lipoprotein cholesterol (HDL-C) in major depression and in depressed men with serious suicidal attempts: Relationship with immune-inflammatory markers. Acta Psychiatr. Scand. 95:212–221.
   PubMed Web of Science ®Google Scholar
• Maes, M., Vandoolaeghe, E., Neels, H., Demedts, P., Wauters, A., Meltzer, H. Y., Altamura, C. and Desnyder, R. (1997b). Lower serum zinc in major depression is a sensitive marker of treatment resistance and of the immune/inflammatory response in that illness. Biol. Psychiatry. 42:349–358.
   PubMed Web of Science ®Google Scholar
• Maes, M., Yirmyia, R., Noraberg, J., Brene, S., Hibbeln, J., Perini, G., Kubera, M., Bob, P., Lerer, B. and Maj, M. (2009b). The inflammatory and neurodegenerative (I and ND) hypothesis of depression: Leads for future research and new drug developments in depression. Metab. Brain Dis. 24:27–53.
   PubMed Web of Science ®Google Scholar
• Mahadik, S. P., Evans, D. and Lal, H. (2001). Oxidative stress and role of antioxidant and omega-3 essential fatty acid supplementation in schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry. 25:463–493.
   PubMed Web of Science ®Google Scholar
• Manji, H. K. and Duman, R. S. (2001). Impairments of neuroplasticity and cellular resilience in severe mood disorders: Implications for the development of novel therapeutics. Psychopharmacol. Bull. 35:5–49.
   PubMedGoogle Scholar
• Marangell, L. B., Martinez, J. M., Zboyan, H. A., Kertz, B., Kim, H. F. and Puryear, L. J. (2003). A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. Am. J. Psychiatry. 160:996–998.
   PubMed Web of Science ®Google Scholar
• Martins, J. G. (2009). EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: Evidence from a meta-analysis of randomized controlled trials. J. Am. Coll. Nutr. 28:525–542.
   PubMed Web of Science ®Google Scholar
• Mattson, M. P. (2007). Mitochondrial regulation of neuronal plasticity. Neurochem. Res. 32:707–715.
   PubMed Web of Science ®Google Scholar
• Mattson, M. P., Gleichmann, M. and Cheng, A. (2008). Mitochondria in neuroplasticity and neurological disorders. Neuron. 60:748–766.
   PubMed Web of Science ®Google Scholar
• McAllister, T. W. (2009). Psychopharmacological issues in the treatment of TBI and PTSD. Clin. Neuropsychol. 23:1338–1367.
   PubMed Web of Science ®Google Scholar
• McEwen, B. S. (2006). Sleep deprivation as a neurobiologic and physiologic stressor: Allostasis and allostatic load. Metabolism. 55:S20–S23.
   PubMed Web of Science ®Google Scholar
• McIntosh, L. J. and Sapolsky, R. M. (1996). Glucocorticoids may enhance oxygen radical-mediated neurotoxicity. Neurotoxicology. 17:873–882.
   PubMed Web of Science ®Google Scholar
• Mischoulon, D., Papakostas, G. I., Dording, C. M., Farabaugh, A. H., Sonawalla, S. B., Agoston, A. M., Smith, J., Beaumont, E. C., Dahan, L. E., Alpert, J. E., Nierenberg, A. A. and Fava, M. (2009). A double-blind, randomized controlled trial of ethyl-eicosapentaenoate for major depressive disorder. J. Clin. Psychiatry. 70:1636–1644.
   PubMed Web of Science ®Google Scholar
• Modai, I., Valevski, A., Dror, S. and Weizman, A. (1994). Serum cholesterol levels and suicidal tendencies in psychiatric inpatients. J. Clin. Psychiatry. 55:252–254.
   PubMed Web of Science ®Google Scholar
• Molendijk, M. L., Bus, B. A., Spinhoven, P., Penninx, B. W., Kenis, G., Prickaerts, J., Voshaar, R. O. and Elzinga, B. M. (2011). Serum levels of brain-derived neurotrophic factor in major depressive disorder: State-trait issues, clinical features and pharmacological treatment. Mol. Psychiatry. 16(11):1088–1095.
   PubMed Web of Science ®Google Scholar
• Morgan, R. E., Palinkas, L. A., Barrett-Connor, E. L. and Wingard, D. L. (1993). Plasma cholesterol and depressive symptoms in older men. Lancet. 341:75–79.
   PubMed Web of Science ®Google Scholar
• Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C. and Wilson, R. S. (2002). Vitamin E and cognitive decline in older persons. Arch. Neurol. 59:1125–1132.
   PubMed Web of Science ®Google Scholar
• Nakagome, K., Yamada, T., Matsumura, H., Sakaki, N. and Sunao, M. (2009). Clinical application of omega 3 polyunsaturated fatty acids in psychiatry. Seishin Shinkeigaku Zasshi. 111:1512–1519.
   PubMedGoogle Scholar
• Neaton, J. D., Blackburn, H., Jacobs, D., Kuller, L., Lee, D. J., Sherwin, R., Shih, J., Stamler, J. and Wentworth, D. (1992). Serum cholesterol level and mortality findings for men screened in the multiple risk factor intervention trial. Multiple risk factor intervention trial research group. Arch. Intern. Med. 152:1490–1500.
   PubMed Web of Science ®Google Scholar
• Nemets, B., Stahl, Z. and Belmaker, R. H. (2002). Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. Am. J. Psychiatry. 159:477–479.
   PubMed Web of Science ®Google Scholar
• Nestler, E. J., Gould, E., Manji, H., Buncan, M., Duman, R. S., Greshenfeld, H. K., Hen, R., Koester, S., Lederhendler, I., Meaney, M., Robbins, T., Winsky, L. and Zalcman, S. (2002). Preclinical models: Status of basic research in depression. Biol. Psychiatry. 52:503–528.
   PubMed Web of Science ®Google Scholar
• Ng, F., Berk, M., Dean, O. and Bush, A. I. (2008). Oxidative stress in psychiatric disorders: Evidence base and therapeutic implications. Int. J. Neuropsychopharmacol. 11:851–876.
   PubMed Web of Science ®Google Scholar
• Nomura, K., Castanon-Cervantes, O., Davidson, A. and Fukuhara, C. (2008). Selective serotonin reuptake inhibitors and raft inhibitors shorten the period of Period1-driven circadian bioluminescence rhythms in rat-1 fibroblasts. Life Sci. 82:1169–1174.
   PubMed Web of Science ®Google Scholar
• Nordstrom, P. and Asberg, M. (1992). Suicide risk and serotonin. Int. Clin. Psychopharmacol. 6(Suppl 6):12–21.
   PubMed Web of Science ®Google Scholar
• Nowak, G., Szewczyk, B., Wieronska, J. M., Branski, P., Palucha, A., Pilc, A., Sadlik, K. and Piekoszewski, W. (2003). Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in rats. Brain Res. Bull. 61:159–164.
   PubMed Web of Science ®Google Scholar
• Olusi, S. O. and Fido, A. A. (1996). Serum lipid concentrations in patients with major depressive disorder. Biol. Psychiatry. 40:1128–1131.
   PubMed Web of Science ®Google Scholar
• Owens, M. J. (2004). Selectivity of antidepressants: From the monoamine hypothesis of depression to the SSRI revolution and beyond. J. Clin. Psychiatry. 65(Suppl 4):5–10.
   PubMed Web of Science ®Google Scholar
• Ozcan, M. E., Gulec, M., Ozerol, E., Polat, R. and Akyol, O. (2004). Antioxidant enzyme activities and oxidative stress in affective disorders. Int. Clin. Psychopharmacol. 19:89–95.
   PubMed Web of Science ®Google Scholar
• Pani, B. and Singh, B. B. (2009). Lipid rafts/caveolae as microdomains of calcium signaling. Cell Calcium. 45:625–633.
   PubMed Web of Science ®Google Scholar
• Papakostas, G. I. (2009). Evidence for S-adenosyl-L-methionine (SAM-e) for the treatment of major depressive disorder. J. Clin. Psychiatry. 70(Suppl 5):18–22.
   PubMed Web of Science ®Google Scholar
• Papakostas, G. I., Petersen, T., Lebowitz, B. D., Mischoulon, D., Ryan, J. L., Nierenberg, A. A., Bottiglieri, T., Alpert, J. E., Rosenbaum, J. F. and Fava, M. (2005). The relationship between serum folate, vitamin B12, and homocysteine levels in major depressive disorder and the timing of improvement with fluoxetine. Int. J. Neuropsychopharmacol. 8:523–528.
   PubMed Web of Science ®Google Scholar
• Papakostas, G. I., Petersen, T., Mischoulon, D., Ryan, J. L., Nierenberg, A. A., Bottiglieri, T., Rosenbaum, J. F., Alpert, J. E. and Fava, M. (2004). Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 1: Predictors of clinical response in fluoxetine-resistant depression. J. Clin. Psychiatry. 65:1090–1095.
   PubMed Web of Science ®Google Scholar
• Partonen, T., Haukka, J., Virtamo, J., Taylor, P. R. and Lonnqvist, J. (1999). Association of low serum total cholesterol with major depression and suicide. Br. J. Psychiatry. 175:259–262.
   PubMed Web of Science ®Google Scholar
• Paul, R. T., McDonnell, A. P. and Kelly, C. B. (2004). Folic acid: Neurochemistry, metabolism and relationship to depression. Hum. Psychopharmacol. 19:477–488.
   PubMed Web of Science ®Google Scholar
• Pavlides, C., Nivon, L. G. and McEwen, B. S. (2002). Effects of chronic stress on hippocampal long-term potentiation. Hippocampus. 12:245–257.
   PubMed Web of Science ®Google Scholar
• Peet, M. (2003). Eicosapentaenoic acid in the treatment of schizophrenia and depression: Rationale and preliminary double-blind clinical trial results. Prostaglandins Leukot Essent Fatty Acids. 69:477–485.
   PubMed Web of Science ®Google Scholar
• Peet, M. and Horrobin, D. F. (2002). A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs. Arch. Gen. Psychiatry. 59:913–919.
   PubMed Web of Science ®Google Scholar
• Pettenuzzo, L. F., Schuck, P. F., Fontella, F., Wannmacher, C. M., Wyse, A. T., Dutra-Filho, C. S., Netto, C. A. and Wajner, M. (2002). Ascorbic acid prevents cognitive deficits caused by chronic administration of propionic acid to rats in the water maze. Pharmacol. Biochem. Behav. 73:623–629.
   PubMed Web of Science ®Google Scholar
• Ponce, J., de la Ossa, N. P., Hurtado, O., Millan, M., Arenillas, J. F., Davalos, A. and Gasull, T. (2008). Simvastatin reduces the association of NMDA receptors to lipid rafts: A cholesterol-mediated effect in neuroprotection. Stroke. 39:1269–1275.
   PubMed Web of Science ®Google Scholar
• Powell, S. R. (2000). The antioxidant properties of zinc. J. Nutr. 130:1447S–1454S.
   PubMed Web of Science ®Google Scholar
• Quiroz, J. A., Gray, N. A., Kato, T. and Manji, H. K. (2008). Mitochondrially mediated plasticity in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology. 33:2551–2565.
   PubMed Web of Science ®Google Scholar
• Rabe-Jablonska, J. and Poprawska, I. (2000). Levels of serum total cholesterol and LDL-cholesterol in patients with major depression in acute period and remission. Med. Sci. Monit. 6:539–547.
   PubMedGoogle Scholar
• Rafter, D. (2001). Biochemical markers of anxiety and depression. Psychiatry Res. 103:93–96.
   PubMed Web of Science ®Google Scholar
• Ramos, M. I., Allen, L. H., Haan, M. N., Green, R. and Miller, J. W. (2004). Plasma folate concentrations are associated with depressive symptoms in elderly Latina women despite folic acid fortification. Am. J. Clin. Nutr. 80:1024–1028.
   PubMed Web of Science ®Google Scholar
• Rees, A. M., Austin, M. P. and Parker, G. B. (2008). Omega-3 fatty acids as a treatment for perinatal depression: Randomized double-blind placebo-controlled trial. Aust. N. Z. J. Psychiatry. 42:199–205.
   PubMed Web of Science ®Google Scholar
• Renner, U., Glebov, K., Lang, T., Papusheva, E., Balakrishnan, S., Keller, B., Richter, D. W., Jahn, R. and Ponimaskin, E. (2007). Localization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling. Mol. Pharmacol. 72:502–513.
   PubMed Web of Science ®Google Scholar
• Rezin, G. T., Amboni, G., Zugno, A. I., Quevedo, J. and Streck, E. L. (2009). Mitochondrial dysfunction and psychiatric disorders. Neurochem. Res. 34:1021–1029.
   PubMed Web of Science ®Google Scholar
• Rezin, G. T., Cardoso, M. R., Goncalves, C. L., Scaini, G., Fraga, D. B., Riegel, R. E., Comim, C. M., Quevedo, J. and Streck, E. L. (2008). Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression. Neurochem. Int. 53:395–400.
   PubMed Web of Science ®Google Scholar
• Richardson, A. J., Cyhlarova, E. and Ross, M. A. (2003). Omega-3 and omega-6 fatty acid concentrations in red blood cell membranes relate to schizotypal traits in healthy adults. Prostaglandins Leukot Essent Fatty Acids. 69:461–466.
   PubMed Web of Science ®Google Scholar
• Roberts, S. H., Bedson, E., Hughes, D., Lloyd, K., Menkes, D. B., Moat, S., Pirmohamed, M., Slegg, G., Thome, J., Tranter, R., Whitaker, R., Wilkinson, C. and Russell, I. (2007). Folate augmentation of treatment - evaluation for depression (FolATED): Protocol of a randomised controlled trial. BMC Psychiatry. 7:65.
   PubMed Web of Science ®Google Scholar
• Robinson, M. E., Teyhen, D. S., Wu, S. S., Dugan, J. L., Wright, A. C., Childs, J. D., Yang, G. and George, S. Z. (2009). Mental health symptoms in combat medic training: A longitudinal examination. Mil Med. 174:572–577.
   PubMed Web of Science ®Google Scholar
• Rothberg, J. M., Fagan, J. and Shaw, J. (1990). Suicide in United States Army personnel, 1985–1986. Mil. Med. 155:452–456.
   PubMed Web of Science ®Google Scholar
• Sachdev, P. S., Parslow, R. A., Lux, O., Salonikas, C., Wen, W., Naidoo, D., Christensen, H. and Jorm, A. F. (2005). Relationship of homocysteine, folic acid and vitamin B12 with depression in a middle-aged community sample. Psychol. Med. 35:529–538.
   PubMed Web of Science ®Google Scholar
• Sanacora, G., Zarate, C. A., Krystal, J. H. and Manji, H. K. (2008). Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nat. Rev. Drug. Discov. 7:426–437.
   PubMed Web of Science ®Google Scholar
• Sanchez-Villegas, A., Doreste, J., Schlatter, J., Pla, J., Bes-Rastrollo, M. and Martinez-Gonzalez, M. A. (2009). Association between folate, vitamin B(6) and vitamin B(12) intake and depression in the SUN cohort study. J Hum. Nutr. Diet. 22:122–133.
   PubMed Web of Science ®Google Scholar
• Sarandol, A., Sarandol, E., Eker, S. S., Erdinc, S., Vatansever, E. and Kirli, S. (2007). Major depressive disorder is accompanied with oxidative stress: Short-term antidepressant treatment does not alter oxidative-antioxidative systems. Hum. Psychopharmacol. 22:67–73.
   PubMed Web of Science ®Google Scholar
• Sarchiapone, M., Camardese, G., Roy, A., Della Casa, S., Satta, M. A., Gonzalez, B., Berman, J. and De Risio, S. (2001). Cholesterol and serotonin indices in depressed and suicidal patients. J. Affect. Disord. 62:217–219.
   PubMed Web of Science ®Google Scholar
• Selby, E. A., Anestis, M. D., Bender, T. W., Ribeiro, J. D., Nock, M. K., Rudd, M. D., Bryan, C. J., Lim, I. C., Baker, M. T., Gutierrez, P. M. and Joiner, T. E., Jr. (2010). Overcoming the fear of lethal injury: Evaluating suicidal behavior in the military through the lens of the Interpersonal-Psychological Theory of Suicide. Clin. Psychol. Rev. 30:298–307.
   PubMed Web of Science ®Google Scholar
• Shelton, R. C. (2007). The molecular neurobiology of depression. Psychiatr. Clin. North Am. 30:1–11.
   PubMed Web of Science ®Google Scholar
• Sher, L. (2007). The role of the hypothalamic-pituitary-adrenal axis dysfunction in the pathophysiology of alcohol misuse and suicidal behavior in adolescents. Int. J. Adolesc. Med. Health. 19:3–9.
   PubMedGoogle Scholar
• Shiah, I. S. and Yatham, L. N. (2000). Serotonin in mania and in the mechanism of action of mood stabilizers: A review of clinical studies. Bipolar. Disord. 2:77–92.
   PubMed Web of Science ®Google Scholar
• Siddiqui, R. A., Harvey, K. A., Zaloga, G. P. and Stillwell, W. (2007). Modulation of lipid rafts by Omega-3 fatty acids in inflammation and cancer: Implications for use of lipids during nutrition support. Nutr. Clin. Pract. 22:74–88.
   PubMed Web of Science ®Google Scholar
• Silvers, K. M., Woolley, C. C., Hamilton, F. C., Watts, P. M. and Watson, R. A. (2005). Randomised double-blind placebo-controlled trial of fish oil in the treatment of depression. Prostaglandins Leukot Essent Fatty Acids. 72:211–218.
   PubMed Web of Science ®Google Scholar
• Sinclair, A. J., Begg, D., Mathai, M. and Weisinger, R. S. (2007). Omega 3 fatty acids and the brain: Review of studies in depression. Asia Pac. J. Clin. Nutr. 16(Suppl 1):391–397.
   PubMed Web of Science ®Google Scholar
• Siwek, M., Dudek, D., Schlegel-Zawadzka, M., Morawska, A., Piekoszewski, W., Opoka, W., Zieba, A., Pilc, A., Popik, P. and Nowak, G. (2010). Serum zinc level in depressed patients during zinc supplementation of imipramine treatment. J. Affect Disord. 126:447–452.
   PubMed Web of Science ®Google Scholar
• Smesny, S., Milleit, B., Hipler, U. C., Milleit, C., Schafer, M. R., Klier, C. M., Holub, M., Holzer, I., Berger, G. E., Otto, M., Nenadic, I., Berk, M., McGorry, P. D., Sauer, H. and Amminger, G. P. (2014). Omega-3 fatty acid supplementation changes intracellular phospholipase A activity and membrane fatty acid profiles in individuals at ultra-high risk for psychosis. Mol. Psychiatry 19:317–324.
   PubMed Web of Science ®Google Scholar
• Smith, P. J. and Blumenthal, J. A. (2010). Diet and neurocognition: Review of evidence and methodological considerations. Curr. Aging Sci. 3:57–66.
   PubMedGoogle Scholar
• Sonawalla, S. B., Papakostas, G. I., Petersen, T. J., Yeung, A. S., Smith, M. M., Sickinger, A. H., Gordon, J., Israel, J. A., Tedlow, J. R., Lamon-Fava, S. and Fava, M. (2002). Elevated cholesterol levels associated with nonresponse to fluoxetine treatment in major depressive disorder. Psychosomatics. 43:310–316.
   PubMed Web of Science ®Google Scholar
• Sorce, S. and Krause, K. H. (2009). NOX enzymes in the central nervous system: From signaling to disease. Antioxid Redox Signal. 11:2481–2504.
   PubMed Web of Science ®Google Scholar
• Sowa-Kucma, M., Legutko, B., Szewczyk, B., Novak, K., Znojek, P., Poleszak, E., Papp, M., Pilc, A. and Nowak, G. (2008). Antidepressant-like activity of zinc: Further behavioral and molecular evidence. J. Neural. Transm. 115:1621–1628.
   PubMed Web of Science ®Google Scholar
• Steegmans, P. H., Hoes, A. W., Bak, A. A., van der Does, E. and Grobbee, D. E. (2000). Higher prevalence of depressive symptoms in middle-aged men with low serum cholesterol levels. Psychosom. Med. 62:205–211.
   PubMed Web of Science ®Google Scholar
• Stoll, A. L., Severus, W. E., Freeman, M. P., Rueter, S., Zboyan, H. A., Diamond, E., Cress, K. K. and Marangell, L. B. (1999). Omega 3 fatty acids in bipolar disorder: A preliminary double-blind, placebo-controlled trial. Arch. Gen. Psychiatry. 56:407–412.
   PubMed Web of Science ®Google Scholar
• Su, K. P. (2009). Biological mechanism of antidepressant effect of omega-3 fatty acids: How does fish oil act as a ‘mind-body interface? Neurosignals. 17:144–152.
   PubMed Web of Science ®Google Scholar
• Su, K. P., Huang, S. Y., Chiu, T. H., Huang, K. C., Huang, C. L., Chang, H. C. and Pariante, C. M. (2008a). Omega-3 fatty acids for major depressive disorder during pregnancy: Results from a randomized, double-blind, placebo-controlled trial. J. Clin. Psychiatry. 69:644–651.
   PubMed Web of Science ®Google Scholar
• Su, K. P., Huang, S. Y., Chiu, C. C. and Shen, W. W. (2003). Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial. Eur. Neuropsychopharmacol. 13:267–271.
   PubMed Web of Science ®Google Scholar
• Su, Y. A., Wu, J., Zhang, L., Zhang, Q., Su, D. M., He, P., Wang, B. D., Li, H., Webster, M. J., Rennert, O. M. and Ursano, R. J. (2008b). Dysregulated mitochondrial genes and networks with drug targets in postmortem brain of patients with posttraumatic stress disorder (PTSD) revealed by human mitochondria-focused cDNA microarrays. Int. J. Biol. Sci. 4:223–235.
   PubMed Web of Science ®Google Scholar
• Suarez, E. C. (1999). Relations of trait depression and anxiety to low lipid and lipoprotein concentrations in healthy young adult women. Psychosom. Med. 61:273–279.
   PubMed Web of Science ®Google Scholar
• Sublette, M. E., Hibbeln, J. R., Galfalvy, H., Oquendo, M. A. and Mann, J. J. (2006). Omega-3 polyunsaturated essential fatty acid status as a predictor of future suicide risk. Am. J. Psychiatry. 163:1100–1102.
   PubMed Web of Science ®Google Scholar
• Syvalahti, E. (1987). Monoaminergic mechanisms in affective disorders. Med. Biol. 65:89–96.
   PubMedGoogle Scholar
• Tagliari, B., dos Santos, T. M., Cunha, A. A., Lima, D. D., Delwing, D., Sitta, A., Vargas, C. R., Dalmaz, C. and Wyse, A. T. (2010). Chronic variable stress induces oxidative stress and decreases butyrylcholinesterase activity in blood of rats. J. Neural. Transm. 117:1067–1076.
   PubMed Web of Science ®Google Scholar
• Takei, N., Kunugi, H., Nanko, S., Aoki, H., Iyo, R. and Kazamatsuri, H. (1994). Low serum cholesterol and suicide attempts. Br. J. Psychiatry. 164:702–703.
   PubMed Web of Science ®Google Scholar
• Tanskanen, A., Hibbeln, J. R., Hintikka, J., Haatainen, K., Honkalampi, K. and Viinamaki, H. (2001). Fish consumption, depression, and suicidality in a general population. Arch. Gen. Psychiatry. 58:512–513.
   PubMed Web of Science ®Google Scholar
• Tatley, M. and Savage, R. (2007). Psychiatric adverse reactions with statins, fibrates and ezetimibe: Implications for the use of lipid-lowering agents. Drug Saf. 30:195–201.
   PubMed Web of Science ®Google Scholar
• Vaidyanathan, V. V., Rao, K. V. and Sastry, P. S. (1994). Regulation of diacylglycerol kinase in rat brain membranes by docosahexaenoic acid. Neurosci. Lett. 179:171–174.
   PubMed Web of Science ®Google Scholar
• van Liempt, S., Vermetten, E., Geuze, E. and Westenberg, H. G. (2006). Pharmacotherapy for disordered sleep in post-traumatic stress disorder: A systematic review. Int. Clin. Psychopharmacol. 21:193–202.
   PubMed Web of Science ®Google Scholar
• Verstreken, P., Ly, C. V., Venken, K. J., Koh, T. W., Zhou, Y. and Bellen, H. J. (2005). Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions. Neuron. 47:365–378.
   PubMed Web of Science ®Google Scholar
• Villar, V. A., Jones, J. E., Armando, I., Palmes-Saloma, C., Yu, P., Pascua, A. M., Keever, L., Arnaldo, F. B., Wang, Z., Luo, Y., Felder, R. A. and Jose, P. A. (2009). G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor. J. Biol. Chem. 284:21425–21434.
   PubMed Web of Science ®Google Scholar
• Virmani, A., Gaetani, F. and Binienda, Z. (2005). Effects of metabolic modifiers such as carnitines, coenzyme Q10, and PUFAs against different forms of neurotoxic insults: Metabolic inhibitors, MPTP, and methamphetamine. Ann. N. Y. Acad. Sci. 1053:183–191.
   PubMed Web of Science ®Google Scholar
• Vreugdenhil, M., Bruehl, C., Voskuyl, R. A., Kang, J. X., Leaf, A. and Wadman, W. J. (1996). Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. Proc. Natl. Acad Sci. U. S. A. 93:12559–12563.
   PubMed Web of Science ®Google Scholar
• Weidner, G., Connor, S. L., Hollis, J. F. and Connor, W. E. (1992). Improvements in hostility and depression in relation to dietary change and cholesterol lowering. The Family Heart Study. Ann. Intern. Med. 117:820–823.
   PubMed Web of Science ®Google Scholar
• Wirz-Justice, A. (2006). Biological rhythm disturbances in mood disorders. Int. Clin. Psychopharmacol. 21(Suppl 1):S11–S15.
   PubMed Web of Science ®Google Scholar
• Wolf, J., Lewicka, J. and Narkiewicz, K. (2007). Obstructive sleep apnea: An update on mechanisms and cardiovascular consequences. Nutr. Metab. Cardiovasc. Dis. 17:233–240.
   PubMed Web of Science ®Google Scholar
• Wolkowitz, O. M., Epel, E. S. and Mellon, S. (2008). When blue turns to grey: Do stress and depression accelerate cell aging? World J. Biol. Psychiatry. 9:2–5.
   PubMed Web of Science ®Google Scholar
• Wolkowitz, O. M., Epel, E. S. and Reus, V. I. (2001). Stress hormone-related psychopathology: Pathophysiological and treatment implications. World J. Biol. Psychiatry. 2:115–143.
   PubMedGoogle Scholar
• Zarate, C. A., Jr. and Manji, H. K. (2008). The role of AMPA receptor modulation in the treatment of neuropsychiatric diseases. Exp. Neurol. 211:7–10.
   PubMed Web of Science ®Google Scholar
• Zarate, C. A., Jr., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S. and Manji, H. K. (2006). A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch. Gen. Psychiatry. 63:856–864.
   PubMed Web of Science ®Google Scholar
• Zhang, L., Zhou, R., Li, X., Ursano, R. J. and Li, H. (2006). Stress-induced change of mitochondria membrane potential regulated by genomic and nongenomic GR signaling: A possible mechanism for hippocampus atrophy in PTSD. Med. Hypotheses. 66:1205–1208.
   PubMed Web of Science ®Google Scholar
• Zimmer, L., Delpal, S., Guilloteau, D., Aioun, J., Durand, G. and Chalon, S. (2000). Chronic n-3 polyunsaturated fatty acid deficiency alters dopamine vesicle density in the rat frontal cortex. Neurosci. Lett. 284:25–28.
   PubMed Web of Science ®Google Scholar
• Zundorf, G. and Reiser, G (2011). Calcium dysregulation and homeostasis of neural calcium in the molecular mechanisms of neurodegenerative diseases provide multiple targets for neuroprotection. Antioxid Redox Signal. 14(7):1275–1288.
   PubMed Web of Science ®Google Scholar