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Biological activity of Stevia rebaudiana Bertoni and their relationship to health

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  • Ahmed, F. N., Naqvi, F. N. and Shafiq, F. (2006). Lipid peroxidation and serum antioxidant enzymes in patients with type 2 diabetes mellitus. Ann. N Y Acad. Sci. 1084:481–489.
  • Akihisa, T., Hamasaki, Y., Tokuda, H., Ukiya, M., Kimura, Y. and Nishino, H. (2004). Microbial transformation of isosteviol and inhibitory effects on Epstein-Barr virus activation of the transformation products. J. Nat. Prod. 67:407–410.
  • Arya, A., Kumar, S. and Kasana, M. S. (2012). Anti-inflammatory activity of in vitro regenerated calli and in vivo plant of Stevia rebaudiana (Bert.) Bertoni. Int. J. Sci. Res. Publ. 2(8):1–5.
  • Barcelo, A. and Rajpathak, S. (2001). Incidence and prevalence of diabetes mellitus in the Americas. Amer. J. Public Health. 10:300–308.
  • Bennett, R. A. and Pegg, A. E. (2004). Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 4:2786–2790.
  • Brantner, A. and Grein, E. (1994). Antibacterial activity of plant extracts used externally in traditional medicine. J. Ethnopharmacol. 44:35–40.
  • Can, A., Akev, N., Ozsoy, N., Bolkent, S., Arda, B. P. and Yanardag, R. (2004). Effect of Aloe vera leaf gel and pulp extracts on the liver in type-II diabetic rat models. Biol. Pharm. Bull. 27:694–698.
  • Chan, P., Xu, D. Y., Liu, J. C., Chen, Y. J., Tomlinson, B., Huang, W. P. and Cheng, J. T. (1998). The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci. 63:1679–1684.
  • Chanda, S. and Nagani, K. (2013). In vitro and in vivo methods for anticancer activity evaluation and some Indian medicinal plants possessing anticancer properties: An overview. J. Pharm. Photochem. 2(2):140–152.
  • Chatsudthipong, V. and Muanprasat, C. (2009). Stevioside and related compounds: Therapeutic benefits beyond sweetness. Pharmacol. Therapeut. 121:41–54.
  • Contreras, S. (2013). Anticariogenic properties and effects on periodontal and effects on periodontal structures of Stevia rebaudiana Bertoni. Narrative review. J. Oral Res. 2(3):158–166.
  • Cragg, G. M. and Newman, D. J. (2000). Antineoplastic agents from natural sources: achievements and future directions. Expet Opin Invest. Drugs. 9:1–15.
  • Curi, R., Alvarez, M., Bazotte, R. B., Botion, L. M., Godoy, J. I. and Bracht, A. (1986). Effect of Stevia rebaudiana on glucose tolerance in normal adult human. Braz. J. Med. Biol. Res. 19:771–774.
  • Curry, L. L. and Roberts, A. (2008). Subchronic toxicity of rebaudioside A. Food Chem. Toxicol. 46(7):S11–S20.
  • Curry, L. L., Roberts, A. and Brown, N. (2008). Rebaudioside A: two-generation reproductive toxicity study in rats. Food Chem. Toxicol. 46(7):S21–S30.
  • Das, S., Das, A., Murphy, R., Punwani, I., Nasution, M. and Kinghorn, A. (1992). Evaluation of the cariogenic potential of the intense natural sweeteners stevioside and rebaudioside A. Caries Res. 26(5):363–366.
  • Das, S., Snehlata, S. V., Das, N. and Srivastava, L. M. (2000). Correlation between total antioxidant status and lipid peroxidation in hypercholesterolemia. Curr. Sci. 78:486–487.
  • Das, K., Dang, R. and Gupta, N. (2009). Comparative antimicrobial potential of different extracts of leaves of Stevia rebaudiana Bert. Int. J. Nat. Eng. Sci. 3(1):65–68.
  • De Slavutzky, S. (2010). Stevia and sucrose effect on plaque formation. J. Für Verbraucherschutz Lebensmittelsicherh. 5(2):213–216.
  • Divisi, D., Di, T. S., Salvemin, S., Garramone, M. and Crisci, R. (2006). Diet and cancer. Acta Biomedica. 77:118–123.
  • Dutta, P. K., Razu, M. M. T., Alam, M. K., Awal, M. A. and Mostofa, M. (2010). Comparative efficacy of aqueous extract of Stevia (Stevia rebaudiana Bertoni) leaves and metformin hydrochloride (Comet®) in streptozotocin induced diabetes mellitus in rats. Int. J. Biol. Res. 2(8):17–22.
  • Faizi, S., Rasool, N., Rashid, M., Khan, R. A., Ahmed, S., Khan, S. A., Ahmad, A., Bibi, N. and Ahmed, S. A. (2003). Evaluation of the antimicrobial property of Polyalthia longifolia var. pendula: isolation of a lactone as the active antibacterial agent from the ethanol extract of the stem. Phytother. Res. 17(10):1177–1181.
  • Gamboa, F. and Chaves, M. (2012). Antimicrobial potential of extracts from Stevia rebaudiana leaves against bacteria of importance in dental caries. Acta Odontologica Latinoamericana. 25(2):171–175.
  • Genus, J. C. M. (2003). Stevioside. Phytochemistry. 64:913–921.
  • Ghanta, S., Banerjee, A., Poddar, A. and Chattopadhyay, S. (2007). Oxidative DNA damage preventive activity and antioxidant potential of Stevia rebaudiana (Bertoni) Bertoni, a natural sweetener. J. Agric. Food Chem. 55:10962–10967.
  • Giacaman, R., Campos, P., Muñoz-Sandoval, C. and Castro, R. (2013). Cariogenic potential of commercial sweeteners in an experimental biofilm caries model on enamel. Arch. Oral Biol. 58:1116–1122.
  • Goodson, J., Cugini, M., Floros, C., Roberts, C., Boileau, A., Bell, M. (2010). Effect of a Truvia™ Rebiana on Plaque pH. Abstract presented at the International Association for Dental Research General Sessions, Barcelona.
  • Gosh, S., Subudhi, E. and Nayak, S. (2008). Antimicrobial assay of Stevia rebaudiana Bertoni elaf extracts against 10 pathogens. Int. J. Integrat. Biol. 2(1):27–31.
  • Gupta, E., Purwar, S., Sundaram, S. and Rai, G. K. (2013). Nutritional and therapeutic values of Stevia rebaudiana: A review. J. Med. Plant Res. 7(46):3343–3353.
  • Hsieh, M. H., Chan, P., Sue, Y. M., Liu, J. C., Liang, T. H., Huang, T. Y., Tomlinson, B., Chow, M. S., Kao, P. F. and Chen, Y. J. (2003). Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: A two-year, randomized, placebo-controlled study. Clin. Ther. 25:2797–2808.
  • Hossain, M. S., Alam, M. S., Asadujjaman, M., Islam, M. M., Rahman, M. A., Islam, M. A. and Islam, A. (2011). Antihyperglycemic and antihyperlipidemic effects of different fractions of Stevia rebaudiana leaves in alloxan induced diabetic rats. Int. J. Pharm. Sci. Res. 287:1722–1729.
  • Imaeda, A., Kaneko, T., Aoki, T., Kondo, Y. and Nagase, H. (2002). DNA damage and the effect of antioxidants in streptozotocin-treated mice. Food Chem. Toxicol. 40:979–987.
  • Jahan, A. I., Mostafa, M., Hossain, H., Nimmi, I., Sattar, A., Alim, A. and Moeiz, S. M. (2010). Antioxidant activity of Stevia rebaudiana Bert leaves from Bangladesh. Bangladesh Pharm. J. 13(2):67–75.
  • Jain, A., Sharma, S., Goyal, M., Dubey, S., Jain, S., Sahu, J., Sharma, A. and Kaushik, A. (2011). Anti-inflammatory activity of Syzygium cumini leaves. Int. J. Phytomed. 2(2).
  • Jaroslav, P., Barbora, H. and Tuulia, H. (2007). Characterization of Stevia rebaudiana by comprehensive two-dimensional liquid chromatography time-of-flight mass spectrometry. J. Chromatogr. A. 1150:85–92.
  • Jayaraman, S., Manoharan, M. S. and Illanchezian, S. (2008). In vitro antimicrobial and antitumor activities of Stevia rebaudiana (Asteraceae) leaf extracts. Trop. J. Pharm. Res. 7(4):1143–1149.
  • Jeppesen, P. B., Gregersen, S., Poulsen, C. R. and Hermansen, K. (2000). Stevioside acts directly on pancreatic beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity. Metabolism. 49(2):208–214.
  • Khan, J. A., Mishra, S. K. and Vandana, K. (2012). Screening of antibacterial properties of Stevia rebaudiana. Int. J. Biol. Pharm. Allied Sci. 1(10):1517–1523.
  • Klepser, T. B. and Kelly, M. W. (1997). Metformin hydrochloride: An antihyperglycemic agent. Amer. J. Health-System Pharm. 54(8):893–903.
  • Krishnamurthi, K. (2007). Screening of natural products for anticancer and antidiabetic properties. Health Admin. 1:69–75.
  • Kumar, Y. A., Singh, S., Dhyani, D. and Ahuja, P. S. (2011). A review on the improvement of stevia [Stevia rebaudiana (Bertoni)]. Canad. J. Plant Sci. 9:11–27.
  • Lee, C. N., Wong, K. I., Liu, J. C., Chen, Y. J., Cheng, J. T. and Chan, P. (2001). Inhibitory effect of steviosides on calcium influx to produce anti-hypertension. Planta Med. 67:796–799.
  • Lemus-Mondaca, R., Vega-Gálvez, A., Zura-Bravo, L. and Ah-Hen, K. (2012). Stevia rebaudiana Bertoni, source of a high-potency natural sweetener: A comprehensive review on the biochemical, nutritional and functional aspects. Food Chem. 132:1121–1132.
  • Li, W. L., Zheng, H. C., Bukuru, J. and De Kimpe, N. (2004). Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J. Ethnopharmacol. 92:1–21.
  • Loganayaki, N., Siddhuraju, P. and Manian, S. (2012). Antioxidant, anti-inflammatory and anti-nociceptive effects of Ammanniabaccifera L. (Lythracceae), a folklore medicinal plant. J. Ethnopharmacol. 140(2):230–233.
  • Mahboob, M., Rahman, M. F. and Grover, P. (2005). Serum lipid peroxidation and antioxidant enzyme levels in male and female diabetic patients. Singapore Med. J. 46:322–324.
  • Mandal, B. and Madan, S. (2013). Preliminary phytochemical screening and evaluation of free radical scavenging activity of Stevia rebaudiana Bertoni from different geographical sources. J. Pharmacogn. Phytochem. 2(1):14–19.
  • Melis, M. S. and Sainati, A. R. (1991). Effect of calcium and verapamil on renal function of rats during treatment with stevioside. J. Ethnopharmacol. 33(3):257–262.
  • Melis, M. S. (1999). Effects of chronic administration of Stevia rebaudiana on fertility in rats. J. Ethnopharmacol. 67(2):157–161.
  • Miguel, M., Alonso, M., Salaices, M., Aleixandre, A. and López-Fandiño, R. (2011). Antihypertensive, ACE inhibitory and vasodilator properties of an egg white hydrolysate: Effect of a simulated intestinal digestion. Food Chem. 104:163–168.
  • Mishra, N. (2011). An Analysis of antidiabetic activity of Stevia rebaudiana extract on diabetic patient. J. Nat. Sci. Res. 1(3).
  • Mizushina, Y., Akihisa, T., Ukiya, M., Hamasaki, Y., Murakami, N. C., Kuriyama, I., Takeuchi, T., Sugawara, F. and Yoshida, H. (2005). Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors. Life Sci. 77:2127–2140.
  • Mohammadi-Sichani, M., Karbasizadeh, V., Aghai, F. and Mofid, E. M. (2012). Effect of different extracts of Stevia rebaudiana leaves on Streptococcus mutans growth. Med. Plant Res. 6(32):4731–4734.
  • Mori, N., Sakanoue, M., Takeuchi, M., Shimpo, K. and Tanabe, T. (1981). Effects of stevioside on fertility in rats. J. Food Hyg. Soc. Japan. 22:409–414.
  • Newman, D. J., Cragg, G. M. and Snader, K. M. (2003). Natural products as sources of new drugs over the period 1981–2002. J. Nat. Prod. 66:1022–1037.
  • Okada, M., Soda, Y., Hayashi, F., Doi, T., Suzuki, J., Miura, K. and Kozai, K. (2005). Longitudinal study of dental caries incidence associated with Streptococcus mutans and Streptococcus sobrinus in pre-school children. J. Med. Microbiol. 54(7):661–665.
  • Okyar, A., Matsuda, K., Sato, M., Yamagata, S. and Sato, T. (2001). Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat Models. Phytother. Res. 15(2):157–161.
  • Pari, L. and Saravanan, R. (2004). Antidiabetic effect of diasulin, a herbal drug, on blood glucose, plasma insulin and hepatic enzymes of glucose metabolism in hyperglycemic rats. Diabetes, Obesity Metabol. 6:286–292.
  • Patel, D. K., Kumar, R., Laloo, D. and Hemalatha, S. (2012). Natural medicines from plant source used for therapy of diabetes mellitus: An overview of its pharmacological aspects. Asian Pacific J. Tropic. Dis. 2(3):239–250.
  • Pezzuto, J. M. (1997). Plants derived anticancer agents. Biochem. Pharmacol. 53:121–133.
  • Preethi, D., Sridhar, T. M., Josthna, P. and Naidu, C. V. (2011). Studies on antibacterial activity, phytochemical analysis of Stevia rebaudiana (Bert.). An important calorie free biosweetner. J. Ecobiotechnol. 3(7):5–10.
  • Rajesh, P., Kannan, V. R. and Durai, M. T. (2010). Effect of Stevia rebaudiana Bertoni ethanolic extract on anti-cancer activity of Erlisch's Ascites carcinoma induced mice. J. Curr. Biotica. 3(4):549–554.
  • Ratheesh, M. and Helen, A. (2007). Anti-inflammatory activity of Ruta graveolens Linn on carrageenan induced paw edema in wistar male rats. African J. Biotechnol. 6(10):1209–1211.
  • Ribnicky, D. M., Poulev, A., Watford, M., Cefalu, W. T. and Raskin, I. (2006). Antihyperglycemic activity of Tarralin, an ethanolic extract of Artemisia dracunculus L. Phytomedicine. 13:550–557.
  • Russo, G. L. (2007). Ins and outs of dietary phytochemicals in cancer chemoprevention. Biochem. Pharmacol. 4:533–544.
  • Russo, M., Spagnuolo, C., Tedesco, I. and Russo, G. L. (2010). Phytochemicals in cancer prevention and therapy: Truth or dare? Toxins. 2:517–551.
  • Sabu, M. C. and Kuttan, R. (2002). Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J. Ethnopharmacol. 81(29):155–160.
  • Schmandke, H. (2004). Sweet-tasting steviol glycoside derivatives with antihyperglycaemic and antihypertensive effects. Ernahrungs-Umschau 51(11):455–462.
  • Sharma, N., Mogra, R. and Upadhyay, B. (2009). Effect of Stevia intervention on lipid profile. Ethno-Med. 3(2):137–140.
  • Savita, S., Sheela, K., Sunanda, S., Shankar, A. and Ramakrishna, P. (2004). Stevia rebaudiana-A functional component for food industry. J. Human Ecol. 15:261–264.
  • Shivanna, N., Naika, M., Khanum, F. and Kaul, V. K. (2012). Antioxidant, anti-diabetic and renal protective properties of Stevia rebaudiana. J. Diabet. Complicat. 27(2):103–113.
  • Singh, S., Garg, V. and Yadav, D. (2013). Antihyperglycemic and antioxidative ability of Stevia rebaudiana (Bertoni) leaves in diabetes induced mice. Int. J. Pharm. Pharmaceut. Sci. 5(2):297–302.
  • Söderling, E., Ekman, T. and Taipale, T. (2008). Growth inhibition of Streptococcus mutans with low xylitol concentrations. Curr. Microbiol. 56(4):382–385.
  • Sporn, M. B. and Suh, N. (2002). Chemoprevention: An essential approach to controlling cancer. Nat. Rev. Cancer. 2:537–543.
  • Suanarunsawata, T., Klongpanichapaka, S., Rungseesantivanona, S. and Chaiyabutrb, N. (2004). Glycemic effect of stevioside and Stevia rebaudiana in streptozotocin-induced diabetic rats. Eastern J. Med. 9:51–56.
  • Surh, Y. J. (2003). Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer. 3:768–780.
  • Sutradhar, S., Preeti, U., Humera, A. and Muneem, M. A. (2013). Comparative study of antioxidant activity of methanolic and ethanolica extracts of Stevia rebaudiana leaves. Res. J. Pharm. Biol. Chem. Sci. 4(2):674–679.
  • Suwannawong, S., Srichan, R., Triratana, T. and Surarit, R. (2004). Effects of stevia extract on caries-inducing properties of Streptococcus sobrinus. Abstract presented at Annual Scientific Meeting, 19th International Association for Dental Research-Southeast Asia Division and 13th Southeast Asia Association for Dental Education, Thailand.
  • Takasaki, M., Konoshima, T., Kozuka, M., Tokunda, H. and Takayasu, J. (2009). Cancer preventive agents. Part 8: Chemopreventive effects of stevioside and related compounds. Bioorg. Med. Chem. 17:600–605.
  • Tavarini, S. and Angelini, L. G. (2013). Stevia rebaudiana Bertoni as a source of bioactive compounds: the effect of harvest time, experimental site and crop age on steviol glycoside content and antioxidant properties. J. Sci. Food Agric. 93:2121–2129.
  • Thylstrup, A. and Fejersko, V. (2000). Texbook of Clinical Cariology. Editorial Doyma: Copenhagen.
  • Tomita, T., Sato, N., Arai, T., Shiraishi, H., Sato, M., Takeuchi, M. and Kamio, Y. (1997). Bactericidal activity of a fermented hot-water extract from Stevia rebaudiana Bertoni and other food-borne pathogenic bacteria. Microbiol. Immunol. 41(12):1005–1009.
  • Triratana, T., Suwannawong, S. K., Srichan, R. and Surarit, R. (2006). Inhibitory Effect of Xilitol and Stevia Extract on Streptococcus Sobrinus. Abstract presented at the International Association for Dental Research General Sessions & Exhibition: Brisbane.
  • Vitery, G., Vargas, S., Gamboa, F., Chavarría, N. and Góme, R. (2010). Actividad inhibitoria de Stevia rebaudiana Bertoni sobre Lactobacillus acidophillus y Streptococcus mutans. Revista Nacional de Odontología. 6:57–64.
  • Yabu, M., Takase, M., Toda, K., Tanimoto, K. and Yasutake, A. (1997). Studies on steviosideo, natural sweetener. Effect on the growth of some oral microorganisms. J. Hiroshima Univ. Dental Soc. 9:12–17.
  • Yamada, A., Ohgaki, S., Noda, T. and Shimizu, M. (1985). Chronic toxicity study of dietary Stevia extracts in F344 rats. J. Food Hyg. Soc. Japan. 26:169–183.
  • Yodyingyuad, V. and Bunyawong, S. (1991). Effect of stevioside on growth and reproduction. Human Reprod. 6(1):158–165.
  • Wheeler, A., Boileau, A. C., Winkler, P. C., Compton, J. C., Prakash, I. and Jiang, X. (2008). Pharmacokinetics of rebaudioside A and stevioside after single oral doses in healthy men. Food Chem. Toxicol. 46(7):S54–S60.

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