Evidences for diabetes and insulin mimetic activity of medicinal plants: Present status and future prospects

References

• Abdulazeez, S. S. (2013). Diabetes treatment: A rapid review of the current and future scope of stem cell research. Saudi Pharm. J. http://dx.doi.org/10.1016/j.jsps.2013.12.012
   Web of Science ®Google Scholar
• Adachi, Y., Yoshida, J., Kodera, Y., Katoh, A., Takada, J. and Sakurai, H. (2006). Bis (allixinato) oxovanadium (IV) complex is a potent anti-diabetic agent: Studies on structure-activity relationship for a series of hydroxypyrone-vanadium complexes. J. Med. Chem. 49:3251–3256.
   PubMed Web of Science ®Google Scholar
• Ahlqvist, E., Ahluwalia, T. S. and Groop, L. (2011). Genetics of type 2 diabetes. Clin. Chem. 57:241–254.
   PubMed Web of Science ®Google Scholar
• Ahmad, F., Khan, M. M., Rastogi, A. K., Chaubey, M. and Kidwai, J. R. (1991). Effect of (−)-epicatechin on cAMP content, insulin release and conversion of proinsulin to insulin in immature and mature rat islets in vitro. Indian J. Exp. Biol. 29:516–520.
   PubMed Web of Science ®Google Scholar
• Alexiou, P. and Demopoulos, V. J. (2010). Medicinal plants used for the treatment of diabetes and its long-term complications. Plants Tradit. Mod. Med.: Chem. Act. 69:175:7756–7766.
   Google Scholar
• Alhabib, S., Aldraimly, M. and Alfarhan, A. (2014). An evolving role of clinical pharmacists in managing diabetes: Evidence from the literature. Saudi Pharm. J. 24(4):441–446.
   PubMed Web of Science ®Google Scholar
• American Diabetes Association. (2008). Diagnosis and classification of diabetes mellitus. Diabetes Care. 31(Suppl. 1):S55–S60.
   PubMedGoogle Scholar
• Armoni, M., Kritz, N., Harel, C., Bar-Yoseph, F., Chen, H., Quon, M. J. and Karnieli, E. (2003). Peroxisome proliferator-activated receptorgamma represses GLUT4 promoter activity in primary adipocytes, and rosiglitazone alleviates this effect. J. Biol. Chem. 278:30614–30623.
   PubMed Web of Science ®Google Scholar
• Atkinson, M. A., Eisenbarth, G. S. and Michels, A. W. (2014). Type 1 diabetes. Lancet. 383:69–82.
   PubMed Web of Science ®Google Scholar
• Atta-ur-Rahman and Khurshid, Zaman. (1989). Medicinal plants with hypoglycemic activity. J. Ethnopharmocol. 26(2):1.
   PubMedGoogle Scholar
• Augusti, K. T. and Sheela, C. G. (1996). Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats. Experientia. 52:115–120.
   PubMedGoogle Scholar
• Ayodhya, S., Kusum, S. and Saxena, A. (2010). Hypoglycaemic activity of different extracts of various herbal plants. Int. J. Res. Ayurveda Pharm. 1:212–224.
   Google Scholar
• Babu, P. S. and Srinivasan, K. (1997). Influence of dietary capsaicin and onion on the metabolic abnormalities associated with streptozotocin induced diabetes mellitus. Mol. Cell. Biochem. 175:49–57.
   PubMed Web of Science ®Google Scholar
• Bell, G., Pictet, R., Rutter, W., Cordell, B., Tischer, E. and Goodman, H. (1980). “Sequence of the human insulin gene”. Nature. 284(5751):26–32.
   PubMed Web of Science ®Google Scholar
• Berger, J., Biswas, C., Vicario, P. P., Strout, H. V., Saperstein, R. and Pilch, P. F. (1989). Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting. Nature. 340:70–72.
   PubMed Web of Science ®Google Scholar
• Bharucha, B., Dwivedi, M., Laddha, N. C., Begum, R., Hardikar, A. A. and Ramachandran, A. V. (2011). Antioxidant rich flavonoids from Oreocnide integrifolia enhance glucose uptake and insulin secretion and protects pancreatic β-cells from streptozotocin insult. BMC Complem. Altern. Med. 11(1):1–13.
   Google Scholar
• Bhushan, S., Meyer, H., Starosta, A. L., Becker, T., Mielke, T., Berninghausen, O. and Beckmann, R. (2010). Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide. Mole. Cell. 40(1):138–146.
   PubMed Web of Science ®Google Scholar
• Biswas, K., Chattopadhyay, I., Banerjee, R. K. and Bandyopadhyay, U. (2002). Biological activities and medicinal properties of neem (Azadiracta indica). Curr. Sci. 82:1336–1345.
   Web of Science ®Google Scholar
• Bnouham, M., Ziyyat, A., Mekhfi, H., Tahri, A. and Legssyer, A. (2006). Medicinal plants with potential antidiabetic activity—A review of ten years of herbal medicine research (1990–2000). Int. J. Diabetes Metab. 14(1):1–25.
   Google Scholar
• Bokesch, H. R., Pannell, L. K., Cochran, P. K., Sowder, R. C., McKee, T. C. et al. (2001). A novel anti-HIV macrocyclic peptide from Palicourea condensata. J. Nat. Prod. 64:249–250.
   PubMed Web of Science ®Google Scholar
• Borch-Johnsen, K., Joner, G., Mandrup-Poulsen, T., Christy, M., Zachau-Christiansen, B., Kastrup, K. and Nerup, J. (1984). Relation between breast-feeding and incidence rates of insulin-dependent diabetes mellitus. Lancet. 324(8411):1083–1086.
   PubMed Web of Science ®Google Scholar
• Borhanuddin, M., Shamsuzzoha, M. and Hussain, A. H. (1994). Hypoglycemic effect of Andrographis paniculata Nees on non-diabetic rabbits. Bangladesh Med. Res. Coun. Bull. 20:24–26.
   PubMedGoogle Scholar
• Bouillon, R., Carmeliet, G., Verlinden, L., Van Etten, E., Verstuyf, A., Luderer, H. F., Lieben, L. et al. (2008). Vitamin D and human health: lessons from vitamin D receptor null mice. Endocrine Rev. 29(6):726–776.
   PubMed Web of Science ®Google Scholar
• Brunetti, A., Chiefari, E. and Foti, D. (2014). Recent advances in the molecular genetics of type 2 diabetes mellitus. World J. Diabetes. 5(2):128–140.
   Google Scholar
• Buesa‐Gomez, J., LaTorre, D., Carlos, J., Dyrberg, T., Landin‐Olsson, M., Mauseth, R. S. and Oldstone, M. (1994). Failure to detect genomic viral sequences in pancreatic tissues from two children with acute‐onset diabetes mellitus. J. Med. Vir. 42(2):193–197.
   PubMed Web of Science ®Google Scholar
• Bustin, M. and Reeves, R. (1996). High-mobility-group chromosomal proteins: Architectural components that facilitate chromatin function. Prog. Nucleic Acid Res. Mol. Biol. 54:35–100.
   PubMed Web of Science ®Google Scholar
• Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A. and Butler, P. C. (2003). Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes. 52:102–110.
   PubMed Web of Science ®Google Scholar
• Chakroborty, B. K., Gupta, S., Gambhir, S. S. and Gode, K. D. (1980). Pancreatic ß-cells regeneration—a novel anti-diabetic mechanism of Pterocarpus marsupium Roxb. Indian J. Pharmacol. 12:123–127.
   Google Scholar
• Chandola, H. M., Tripathi, S. N. and Udupa, K. N. (1980). Hypoglycemic response of Cinnamonum tamala in patients of maturity onset (NIDDM) diabetes. J. Res. Ayurveda Siddha. 1:275–290.
   Google Scholar
• Chandra, M., Chandra, N., Agrawal, R., Kumar, A., Ghatak, A. and Pandey, V. C. (1994). The free radical system in ischemic heart disease. Int. J. Cardiol. 43:121–125.
   PubMed Web of Science ®Google Scholar
• Chattopadhyay, R. R. (1993). Hypoglycemic effect of Ocimum sanctum leaf extract in normal and streptozotocin diabetic rats. Indian J. Exp. Biol. 31:891–893.
   PubMedGoogle Scholar
• Chattopadhyay, R. R. (1999). A comparative evaluation of some blood sugar lowering agents of plant origin. J. Ethnopharmacol. 67:367–372.
   PubMed Web of Science ®Google Scholar
• Chauhan, A., Sharma, P. K., Srivastava, P., Kumar, N. and Dudhe, R. (2010). Plants having potential antidiabetic activity: A review. Der Pharmacia Lett. 2(3):369–387.
   Google Scholar
• Chopra, R. N., Chopra, I. C., Handa, K. L. and Kapur, L. D. (1958). Indigenous Drugs of India, 2nd ed., pp. 314–316. UN Dhur and Sons, Calcutta.
   Google Scholar
• Crowther, C. A., Hiller, J. E., Moss, J. R., McPhee, A. J., Jeffries, W. S. and Robinson, J. S. (2005). Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. New Engl. J. Med.. 352(24):2477–2486.
   PubMed Web of Science ®Google Scholar
• Das, A. V., Padayathi, P. S. and Paulose, C. S. (1996). Effect of leaf extract of Aegle marmelose (L.) Correa exRoxb. on histological and ultra structural changes in tissue of streptozotocin induced diabetic rats. Indian J. Exp. Biol. 34:341–345.
   PubMedGoogle Scholar
• Defronzo, R. A. (2009). From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 58:773–795.
   PubMed Web of Science ®Google Scholar
• Deluca, H. F. (2004). Overview of general physiologic features and functions of vitamin D. Am. J. Clin. Nutr. 80(6 Suppl):1689S–1696S.
   PubMed Web of Science ®Google Scholar
• Dey, L., Anoja, S. A. and Yuan, C. S. (2002). Alternative therapies for type 2 diabetes. Alternative Med. Rev. 7:45–58.
   PubMedGoogle Scholar
• Donga, J. J., Surani, V. S., Sailor, G. U., Chauhan, S. P. and Seth, A. K. (2011). A systematic review on natural medicine used for therapy of diabetes mellitus of some Indian medicinal plants, Int. J. Pharm. Sci. 2:36–72.
   Google Scholar
• Dor, Y. and Glaser, B. (2013). Beta-cell dedifferentiation and type 2 diabetes. New Engl. J. Med. 368(6):572–573.
   PubMed Web of Science ®Google Scholar
• Doria, A., Patti, M. E. and Kahn, C. R. (2008). The emerging genetic architecture of type 2 diabetes. Cell Metab. 8:186–200.
   PubMed Web of Science ®Google Scholar
• Ezuruike, U. F. and Prieto, J. M. (2014). The use of plants in the traditional management of diabetes in Nigeria: Pharmacological and toxicological considerations. J. Ethnopharmacol. 155(2):857–924.
   PubMed Web of Science ®Google Scholar
• Felter, S. P., Vassallo, J. D., Carlton, B. D. and Daston, G. P. (2006). A safety assessment of coumarin taking into account species-specificity of toxico kinetics. Food Chem. Toxicol. 44:462–475.
   PubMed Web of Science ®Google Scholar
• Fonteles, M. C., Huang, L. C. and Larner, J. (1996). Infusion of pH 2.0 D-chiro-inositol glycan insulin putative mediator normalizes plasma glucose in streptozotocin diabetic rats at a dose equivalent to insulin without inducing hypoglycaemia. Diabetologia. 39:731–734.
   PubMed Web of Science ®Google Scholar
• Foti, D., Chiefari, E., Fedele, M., Iuliano, R., Brunetti, L., Paonessa, F., Manfioletti, G., Barbetti, F., Brunetti, A., Croce, C. M., Fusco, A. and Brunetti, A. (2005). Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice. Nat. Med. 11:765–773.
   PubMed Web of Science ®Google Scholar
• Fukudome, S., Jinsmaa, Y., Matsukawa, T., Sasaki, R. and Yoshikawa, M. (1997). Release of opioid peptides, gluten exorphins by the action of pancreatic elastase. FEBS Lett. 412:475—479.
   Google Scholar
• Fukudome, S. and Yoshikawa, M. (1992). Opioid peptides derived from wheat gluten: their isolation and characterization. FEBS Lett. 296:107–111.
   PubMed Web of Science ®Google Scholar
• Ganda, O. P. (1995). Prevalence and incidence of secondary and other types of diabetes. Diabetes Am. 95:69–84.
   Google Scholar
• Gao, H., Huang, Y. N., Gao, B. and Li, P. (2008). Inagaki C, Kawabata J. Inhibitory effect on a-glucosidase by Adhatoda vasica Nees. Food Chem. 108:965–972.
   PubMed Web of Science ®Google Scholar
• Garcia-Medina, J. J., Pinazo-Duran, M. D., Garcia-Medina, M., Zanon-Moreno, V. and Pons-Vazquez, S. (2011). A 5-year follow-up of antioxidant supplementation in type 2 diabetic retinopathy. Eur. J. Ophthalmol. 21:637–643.
   PubMed Web of Science ®Google Scholar
• Gaw, A. C., Ding, Q., Levine, R. E. and Gaw, H. (1998). The clinical characteristics of possession disorder among 20 Chinese patients in the Hebei province of China. Psychiat. Serv. 49:360–365.
   PubMed Web of Science ®Google Scholar
• Gerstein, H. (1994). Cow's milk exposure and type 1 diabetes mellitus. Diabetes Care. 17:13–19.
   PubMed Web of Science ®Google Scholar
• Glugliano, D., Ceriello, A. and Paolisso, G. (1996). Oxidative stress and diabetic vascular complications. Diabetes. Care. 19:257–267.
   PubMed Web of Science ®Google Scholar
• Goldstein, B. J. (2002). Insulin resistance as the core defect in type 2 diabetes mellitus. Am. J. Cardiol. 90(5):3–10.
   Google Scholar
• Gorjanovic, S., Beljanski, M. V., Gavrovic-Jankulovic, M., Gojgic-Cvijovic, G., Pavlovic, M. D. et al. (2007). Antimicrobial activity of malting barley grain Thaumatin-like protein isoforms, S and R. J. I. Brewing. 113:206–212.
   Web of Science ®Google Scholar
• Gray, A. M. and Flatt, P. R. (1999). Insulin-secreting activity of the traditional antidiabetic plant Viscum album (mistletoe). J. Endoc. 160(3):409–414.
   PubMed Web of Science ®Google Scholar
• Gulfraz, M., Iftikhar, F., Imran, M., Zeenat, A., Asif, S. and Shah, I. (2011). Compositional analysis and antimicrobial activity of various honey types of Pakistan. International Journal of Food Science & Technology. 46(2):263–267.
   Web of Science ®Google Scholar
• Gupta, R. K., Kesari, A. N., Watal, G., Murthy, P. S., Chandra, R. and Tandon, V. (2005). Nutritional and hypoglycemic effect of fruit pulp of Annona squamosa in normal healthy and alloxan-induced diabetic rabbits. Ann. Nutr. Metab. 49:407–413.
   PubMed Web of Science ®Google Scholar
• Gupta, Rahul, Kumar, Gaurav Bajpai, Johri, Samta and Saxena, A. M. (2008). An Overview of indian novel traditional medicinal plants with antidiabetic potentials. Afr. J. Tradit., Complem. Alternative Med. 5(1):1–17.
   Web of Science ®Google Scholar
• Gupta, S., Kataria, M., Gupta, P. K., Murganandan, S. and Yashory, R. C. (2004). Protective role of extract of neem seeds in diabetes caused by Streptozotocin in rats. J. Ethnopharmacol. 90:185–189.
   PubMed Web of Science ®Google Scholar
• Handa, S. S., Chawla, A. S. and Maninder. (1989). Hypoglycemic plants—A review. Fitoterapia. 60(3):195–224.
   Google Scholar
• Hannan, J. M. A., Ali, L., Khaleque, J., Akhter, M., Flatt, P. R. and Abdel-Wahab, Y. H. (2012). Antihyperglycaemic activity of Asparagus racemosus roots is partly mediated by inhibition of carbohydrate digestion and absorption, and enhancement of cellular insulin action. Br. J. Nutr. 107(09):1316–1323.
   PubMed Web of Science ®Google Scholar
• Hannan, J. M., Marenah, L., Ali, L., Rokeya, B., Flatt, P. R. and Abdel-Wahab, Y. H. (2006). Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic ß-cells. J. Endocrinol. 189:127–136.
   PubMed Web of Science ®Google Scholar
• Haron, M. N., Rahman, W. F. W. A., Sulaiman, S. A. and Mohamed, M. (2014). Tualang honey ameliorates restraint stress-induced impaired pregnancy outcomes in rats. Eur. J. Integrative Med. 6(6):657–663.
   Web of Science ®Google Scholar
• Hattori, A., Yamada, N., Nishikawa, T., Fukuda, H. and Fujino, T. (2005). Anti-diabetic effects of ajoene in genetically diabetic KK-A(y) mice. J. Nutr. Sci. Vitaminol. 51:382–384.
   PubMed Web of Science ®Google Scholar
• Hegde, P. L., Rao, H. A. and Rao, P. N. (2014). A review on Insulin plant (Costus igneus Nak). Pharmacogn. Rev. 8:67–72.
   PubMedGoogle Scholar
• Henriksson, M., Nordling, E., Melles, E., Shafqat, J., Ståhlberg, M., Ekberg, K. et al. (2005). Separate functional features of proinsulin C-peptide. Cell. Mol. Life Sci. 62(15):1772–1778.
   PubMed Web of Science ®Google Scholar
• Hummel, M., Bonifacio, E., Naserke, H. E. and Ziegler, A. G. (2002). Elimination of dietary gluten does not reduce titers of type 1 diabetes-associated autoantibodies in high-risk subjects. Diabetes Care. 25:1111–1116.
   PubMed Web of Science ®Google Scholar
• Husen, R., Pihie, A. H. and Nallappan, M. (2004). Screening for antihyperglycaemic activity in several local herbs of Malaysia. J. Ethnopharmacol. 95:205–208.
   PubMed Web of Science ®Google Scholar
• Ingelsson, E., Langenberg, C., Hivert, M. F., Prokopenko, I., Lyssenko, V., Dupuis, J., Mägi, R., Sharp, S., Jackson, A. U., Assimes, T. L. et al. (2010). Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes. 59:1266–1275.
   PubMed Web of Science ®Google Scholar
• Jafri, M. A., Subhani, M. J., Javed, K. and Singh, S. (1999). Hepatoprotective activityof leaves of Cassia occidentalis against paracetamol and ethyl alcohol in toxication in rats. J. Ethnopharmacol. 66:355–361.
   PubMed Web of Science ®Google Scholar
• Jain, R. C. and Vyas, C. R. (1975). Garlic in alloxan-induced diabetic rabbits. Am. J. Clin. Nutr. 28:684–685.
   PubMed Web of Science ®Google Scholar
• Jiang, G. and Zhang, B. B. (2003). Glucagon and regulation of glucose metabolism. Am. J. Physiol.–Endocrinol. Metab. 284(4):E671–E678.
   PubMed Web of Science ®Google Scholar
• Juhela, S., Hyöty, H., Roivainen, M., Härkönen, T., Putto-Laurila, A., Simell, O. and Ilonen, J. (2000). T-cell responses to enterovirus antigens in children with type 1 diabetes. Diabetes 49(8):1308–1313.
   PubMed Web of Science ®Google Scholar
• Kaleem, M., Asif, M., Ahmed, Q. U. and Bano, B. (2006). Anti-diabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Med. J. 47:670–675.
   PubMedGoogle Scholar
• Kandror, K. V. and Pilch, P. F. (1996). Compartmentalization of protein traffic in insulin-sensitive cells. Am. J. Physiol. 271:E1–14
   PubMed Web of Science ®Google Scholar
• Kar, A., Choudhary, B. K. and Bandyopadhyay, N. G. (2003). Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J. Ethnopharmacol. 84:105–108.
   PubMed Web of Science ®Google Scholar
• Kelkar, S. M., Kaklij, G. S. and Bapat, V. A. (2001). Determination of hypoglycemic activity in Allium cepa (onion) tissue cultures. Indian J. Biochem. Biophys. 38:277–279.
   PubMed Web of Science ®Google Scholar
• Khatun, H., Rahman, A., Biswas, M. and Islam, A. U. (2011). Water-soluble fraction of Abelmoschus esculentus L Interacts with glucose and metformin hydrochloride and alters their absorption kinetics after co administration in rats. IISRN Pharma.
   Google Scholar
• Kim, J. Y., Park, S. C., Hwang, I., Cheong, H., Nah, J. W. et al. (2009). Protease inhibitors from plants with antimicrobial activity. Int. J. Mol. Sci. 10:2860—2872.
   Google Scholar
• Kolb, H. and Pozzilli, P. (1999). Cow's milk and type 1 diabetes: the gut immune system deserves attention. Immun. Today. 20:108–110.
   PubMedGoogle Scholar
• Kulkarni, C. P., Bodhankar, S. L., Ghule, A. E., Mohan, V. and Thakurdesai, P. A. (2012). Antidiabetic activity of Trigonella foenumgraecum L. Seeds extract (IND01) in neonatal streptozotocin-induced (n-stz) rats. Diabetol. Croatica. 41(1):29–40.
   Google Scholar
• Kumari, K., Mathew, B. C. and Augusti, K. T. (1995). Hypoglycemic and hypolipidemic effects of S-methyl cysteine sulfoxide isolated from Allium cepa Linn. Indian J. Biochem. Biophys. 32:49–54.
   PubMed Web of Science ®Google Scholar
• Larner, J. (1985). Insulin and oral hypoglocaemic drugs. In Glucogon, in the Pharmacological Basis of Therapeutics. Alfred Goodman et al., editors. 7th ed. pp.1490–1516. Macmillan, New York.
   Google Scholar
• Li, Y., Qi, Y., Huang, T., Yamahara, J. and Roufogalis, B. (2008). Pomegranate flower: A unique traditional antidiabetic medicine with dual PPAR-alpha/-gamma activator properties. Diabetes, Obesity Metab. 10(1):10–17.
   PubMed Web of Science ®Google Scholar
• Lipinski, B. (2001). Pathophysiology of oxidative stress in diabetes mellitus. J. Diabetes Complicat. 15:203–210.
   PubMed Web of Science ®Google Scholar
• Lolitkar, M. M. and Rao, M. R. R. (1966). Pharmacology of a hypoglycemic principle isolate from fruit of Momordica charantia Linn. Indian J. Pharm. 28:129–133.
   Google Scholar
• Lucassen, A. M., Julier, C., Beressi, J. P., Boitard, C., Froguel, P., Lathrop, M. and Bell, J. I. (1993). Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR. Nat. Genet. 4:305–310.
   PubMed Web of Science ®Google Scholar
• MacFarlane, A. J., Burghardt, K. M., Kelly, J., Simell, T., Simell, O., Altosaar, I. and Scott, F. W. (2003). A type 1 diabetes-related protein from wheat (Triticum aestivum) cDNA clone of a wheat storage globulin, Glb1, linked to islet damage. J. Biol. Chem. 278(1):54–63.
   PubMed Web of Science ®Google Scholar
• Manickam, M., Ramanathan, M., Johromi, M. A., Chansouria, J. P. and Ray, A. B. (1997). Anti-hyperglycemic activity of phenolics from Pterocarpus marsupium. J. Nat. Prod. 60:609–610.
   PubMed Web of Science ®Google Scholar
• Manukumar, H. M., Ananda, A. P., Vishwanathan. Deepa and Siddhagangaia. (2013a). Study of physicochemical parameters and antioxidant in honey collected from different locations of India. Int. J. Pharm. Life Sci. 4(12):3159–3165.
   Google Scholar
• Manukumar, H. M., Prathima, V. R., Lokesh, S., Gowtham, G. and Suresha, S. (2014). Impact of partial defatting on nutritional, mineral, functional properties and effect of solvents to evaluate in-vitro antioxidant, anti-diabetic potentiality from flaxseed (Linum usitatissimum) extracts. World J. Pharm. Sci. 3(6):1406–1427.
   Google Scholar
• Manukumar, H. M., Prathima, V. R., Sowmya, Siddhagangaia and Thribhuvan, K. R. (2013c). Study of nutritional quality, phytochemical constituents and antioxidant activities by different solvents of nettle (Urtica urens) from Madikeri-karnataka state. Int. J. Pharm. Pharm. Sci. 3(5):112–119.
   Google Scholar
• Manukumar, H. M. and Shruthi, K. C. (2014). Screening of thrombolytic (Clot-Busting) activity from geographically separated two varieties of honey from India: An In-Vitro approach. World J. Pharm. Sci. 3(3):1428–1439.
   Google Scholar
• Manukumar, H. M. and Thribhuvan, K. R. (2014). In-vitro Evaluation of physicochemical, antioxidant and anti-inflammatory activity of pomegranate (Punica grantum L.) juice and seed hydro extracts. Int. J. Pharma Bio Sci. 5(1):131–141.
   Google Scholar
• Manukumar, H. M. and Vanitha, M. T. (2014). Comparative evaluation of In-vitro anthelmintic potency of delonix regia (Rafin) and Caesalpinia pulcherrima (Linn) flower extracts By aqueous and methanol as a solvent. Int. J. Pharm. Res. Dev. 5(12):033–040.
   Google Scholar
• Manukumar, H. M., Prathima, V. R., Guru, C. and Kurinji, V. (2013b). Impact of germination time on protein solubility, digestibility and in-vitro antioxidant, anti- inflammatory activity of sorghum grains. Int. J. Pharm Technol. Res. 6(1):117–128.
   Google Scholar
• Manukumar, Honnayakanahalli Marichenne Gowda and Umesha, Sharanaiah. (2015). Assessment of membrane stabilizing activity from honey: An In-Vitro approach. ACTA Sci. Polonorum Technologia Aliment. 14(1):85–90.
   PubMed Web of Science ®Google Scholar
• Mathew, P. T. and Augusti, K. T. (1973). Studies on the effect of allicin (diallyl disulphide-oxide) on alloxan diabetes. Hypoglycemic action and enhancement of serum insulin effect and glycogen synthesis. Indian J. Biochem. Bioph. 10:209–212.
   PubMed Web of Science ®Google Scholar
• Mathieu, C., Gysemans, C., Giulietti, A. and Bouillon, R. (2005). Vitamin D and diabetes. Diabetologia. 48:1247–1257.
   PubMed Web of Science ®Google Scholar
• Matteucci, E. and Giampietro, O. (2000). Oxidative stress in families of type 1 diabetic patients. Diabetes Care. 23:1182–1186.
   PubMed Web of Science ®Google Scholar
• McCarthy, M. I. (2010). Genomics, type 2 diabetes, and obesity. New Engl. J. Med. 363:2339–2350.
   PubMed Web of Science ®Google Scholar
• Mukherjee, P. K., Maiti, K., Mukherjee, K. and Houghton, P. J. (2006). Leads from Indian medicinal plants with hypoglycemic potentials. J. Ethnopharmacol. 106:1–28.
   PubMed Web of Science ®Google Scholar
• Nadkarni, A. K. (1954). Indian Materia Medics. 3rd ed., p. 21. Popular Book Depot, Bombay..
   Google Scholar
• Nain, Parminder et al. (2012). Antidiabetic and antioxidant potential of Emblica officinalis Gaertn. Leaves extract in streptozotocin-induced type-2 diabetes mellitus (T2DM) rats. J. Ethnopharmacol. 142(1):65–71.
   Web of Science ®Google Scholar
• Naziroglu, M. and Cay, M. (2001). Protective role of intraperitoneally administered vitamin E and selenium on the oxidative defense mechanisms in rats with diabetes induced by streptozotocin. Biol. Trace Elem. Res. 47:475–488.
   Google Scholar
• Nerup, J., Platz, P., Andersen, O. O., Christy, M., Lyngsoe, J., Poulsen, J. E. and Svejgaard, A. (1974). HL-A antigens and diabetes mellitus. Lancet. 304(7885):864–866.
   Google Scholar
• Ng, T. B., Wong, C. M., Li, W. W. and Yeung, H. W. (1986). Isolation and characterization of a galactose binding lectin with insulinomimetic activities from the seeds of the bitter gourd Momordica charantia (Family: Cucurbitaceae). Int. J. Pept. Prot. Res. 28:163–172.
   PubMedGoogle Scholar
• Noor, A., Bansal, V. S. and Vijayalakshmi, M. A. (2013). Current update on anti-diabetic biomolecules from key traditional Indian medicinal plants. Curr. Sci. 104(6):721–727.
   Web of Science ®Google Scholar
• Norris, J. M. and Scott, F. W. (1996). A meta analysis of infant diet and insulin-dependent diabetes mellitus: Do biases play a role? Epidemiology. 7:87–92.
   PubMed Web of Science ®Google Scholar
• Okyar, A., Can, A., Akev, N., Baktir, G. and Sutulupinar, N. (2001). Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models. Phytotherapy Res. 15:157–161.
   PubMed Web of Science ®Google Scholar
• Omi, T., Brenig, B., Spilar Kramer, S., Iwamoto, S., Stranzinger, G. and Neuenschwander, S. (2005). Identification and characterization of novel peroxisome proliferator-activated receptor-gamma (PPAR-gamma) transcriptional variants in pig and human. J. Anim. Breed. Genet. 122(Suppl 1):45–53.
   PubMedGoogle Scholar
• Pandey, M. C. and Sharma, V. P. (1975). Hypoglycemic effect of bark of Pterocarpous marsupium Roxb.(Bijaka) on alloxan induced diabetes. Med. Surg. 15(21):86–88.
   Google Scholar
• Panicker, V. P. and Gopalakrishnan, A. (2014). Anti-diabetic medicinal plants of India—A review. World J. Pharm. Pharmaceut. Sci. 3(7):482–495.
   Google Scholar
• Papas, A. M. (1996). Determinants of antioxidant status in humans. Lipids. 31:S77–S82.
   PubMed Web of Science ®Google Scholar
• Patel, P., Harde, P., Pillai, J., Darji, N. and Patel, B. (2012). Antidiabetic herbal drugs a review. Pharmacophore. 3(1):18–29.
   Google Scholar
• Patterson, C. C., Dahlquist, G., Soltesz, G., Green, A. and Eurodiab ACE Study Group. (2001). Is childhood-onset type I diabetes a wealth-related disease? An ecological analysis of European incidence rates. Diabetologia. 44(3):B9–B16.
   Google Scholar
• Paulose, C. S., Ponnachan, P. T. C. and Panikkar, K. R. (1993). Effect of leaf extract of Aegle marmelose. Indian J. Exp. Biol. 31:345–347.
   PubMedGoogle Scholar
• Permutt, M. A., Koranyi, L., Keller, K., Lacy, P. E., Scharp, D. W. and Mueckler, M. (1989). Cloning and functional expression of a human pancreatic islet glucose-transporter cDNA. Proc. Nat.l Acad. Sci. USA. 86:8688–8692.
   PubMed Web of Science ®Google Scholar
• Ponnachan, P. T., Paulose, C. S. and Panikkar, K. R. (1993). Effect of leaf extract of Aegle marmelose in diabetic rats. Indian J. Exp. Biol. 31:345–347.
   PubMedGoogle Scholar
• Qu, H. Q., Montpetit, A., Ge, B., Hudson, T. J. and Polychronakos, C. (2007). Toward further mapping of the association between the IL2RA locus and type 1 diabetes. Diabetes. 56:1174–1176.
   PubMed Web of Science ®Google Scholar
• Rahier, J., Guiot, Y., Goebbels, R. M., Sempoux, C. and Henquin, J. C. (2008). Pancreatic beta-cell mass in European subjects with type 2 diabetes. Diabetes, Obesity Metab. 10:32–42.
   PubMed Web of Science ®Google Scholar
• Rai, V., Iyer, U. and Mani, U. V. (1997). Effect of Tulasi (Ocimum sanctum) leaf powder supplementation on blood sugar levels, serum lipids and tissue lipids in diabetic rats. Plant Foods Hum. Nutr. 50:9–16.
   PubMed Web of Science ®Google Scholar
• Rajasekaran, S., Ravi, K., Sivagnanam, K. and Suramanian, S. (2006). Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin. Exp. Pharmacol. Physiol. 33:232–237.
   PubMed Web of Science ®Google Scholar
• Ramasubbu, N., Sundar, K., Ragunath, C. and Rafi, M. M. (2004). Structural studies of a Phe256Trp mutant of human salivary alphaamylase: implications for the role of a conserved water molecule in enzyme activity. Arch. Biochem. Biophys. 421:115–124.
   PubMed Web of Science ®Google Scholar
• Rashid, A. N. M., Hossain, M. S., Naim Hassan, B., Kumar Dash, M., Sapon, A. and Sen, M. K. (2014). A review on medicinal plants with antidiabetic activity. J. Pharmaco. Phytochem. 3(4):149–159.
   Google Scholar
• Roja, N. M., Satyavani, S., Sadhana, B., Nikitha, T. and Padal, S. B. (2014). A review on ethanomedicinal plants having antidiabetic activity in north coastal andhra pradesh, india. BMR Biol. 1(1):1–9.
   Google Scholar
• Rupesh kumar, M., Mohammed, Fariyaz, S., Kavitha, K., Jagadeesh Singh, S. D. and Dhanaraj, S. S. (2014). Indian medicinal plants with antidiabetic and related beneficial effects—A review. World J. Pharm. Sci. 3:3.
   Google Scholar
• Said, F., Sofowora, E. A., Malcolm, S. A. and Hofer, A. (1969). An investigation into the efficacy of Ocimum gratissimum as used in Nigerian native medicine. Planta Medica. 17(02):195–200.
   PubMedGoogle Scholar
• Sardesai, V. M. (1995). Role of antioxidants in health maintenance. Nutr. Clin. Practice. 10:19–25.
   PubMedGoogle Scholar
• Satyanarayan, K., Murthy, D., Narayan Rao, D., Krishna, R. and Gopal, L. B. (1978). A preliminary study on hypoglycemic and antihyperglycemic effect of Azadiracta indica. Indian J. Pharm. 10:247–250.
   Google Scholar
• Satyavati, G. V., Gupta, A. and Tandon, N. T. (1978). Medicinal plants of India, New Delhi. Indian Med. Res. 2:875.
   Google Scholar
• Satyavati, G. V., Neeraj, T. and Madhu, S. (1989). Indigenous plant drugs for diabetes mellitus. Int. J. Diabetes Dev. Countries. 9:1–35.
   Google Scholar
• Saxena, A. M., Mukherjee, S. K. and Shukla, G. (2006). Progress of diabetes research in India during 20th century. National Institute of Science and Communication (CSIR), New Delhi, 1–104.
   Google Scholar
• Saxena, R., Elbers, C. C., Guo, Y., Peter, I., Gaunt, T. R., Mega, J. L., Lanktree, M. B., Tare, A., Castillo, B. A., Li, Y. R., Johnson, T., Bruinenberg, M., Gilbert-Diamond, D., Rajagopalan, R., Voight, B. F., Balasubramanyam, A., Barnard, J. and Bauer, F. (2012). Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am. J. Hum. Genet. 90:410–425.
   PubMed Web of Science ®Google Scholar
• Scheen, A. J. (2007). Glucagon-like peptide-1 (GLP-1), new target for the treatment of type 2 diabetes. Revue Med. Liege. 62:217–221.
   PubMedGoogle Scholar
• Scheen, A. J., Radermecker, R. P., Philips, J. C. and Paquot, N. (2007). Incretin mimetics and incretin enhancers for the treatment of type 2 diabetes. Revue Méd. Suisse. 3:1884, 1886–1888.
   PubMedGoogle Scholar
• Sharma, K. A., Kumar, R., Mishra, A. and Gupta, R. (2010). Problems associated with clinical trials of Ayurvedic medicines. Revista Bras. de Farmacognosia. 20(2):276–281.
   Web of Science ®Google Scholar
• Shepherd, P. R. and Kahn, B. B. (1999). Glucose transporters and insulin action—implications for insulin resistance and diabetes mellitus. New Eng. J. Med. 341:248–257.
   PubMed Web of Science ®Google Scholar
• Sheu, S. C. and Lai, M. H. (2012). Composition analysis and immuno-modulatory effect of okra (Abelmoschus esculentus L.) extract. Food Chem. 134(4):1906–1911.
   Google Scholar
• Shibib, B. A., Khan, L. A. and Rahman, R. (1993). Hypoglycemic activity of Coccinia indica and Momordica charantia in diabetic rats depression of the hepatic gluconeogenic enzymes glucose-6-phosphatase and fructose1,6-bisphosphatase and elevation of both liver and red-cell shunt enzyme glucose-6-phosphate dehydrogenase. Biochem. J. 292:267–270.
   PubMed Web of Science ®Google Scholar
• Shirwaikar, A., Rajendra, K., Dinesh Kumar, C. and Bodla, R. (2004). Hypoglycemic activity of aqueous leaf extracts of Annona squamosa in streptozotocin-nicotinamide type 2 diabetic rats. J. Ethnopharmacol. 91:171–175.
   PubMed Web of Science ®Google Scholar
• Smyth, D., Cooper, J. D., Collins, J. E., Heward, J. M. and Franklyn, J. A. (2004). Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes: Evidence for its role as a general autoimmunity locus. Diabetes. 53:3020–3023.
   PubMed Web of Science ®Google Scholar
• Sun, X., Yu, W. and Hu, C. (2014). Genetics of type 2 diabetes: insights into the pathogenesis and its clinical application. BioMed Res. Int. 2014:1–15.
   Google Scholar
• Tahiliani, P. and Kar, A. (2003). Mitigation of thyroxine-induced hyperglycaemia by two plants extracts. Phytotherapy Res. 17:294–296.
   PubMed Web of Science ®Google Scholar
• Tanaka, M., Misawa, E., Ito, Y., Habara, N., Nomaguchi, K., Yamada, M., Toida, T., Hayasawa, H., Takase, M. and Inagaki Higuchi, R. (2006). Identification of five phytosterols from Aloe vera gel as anti-diabetic compounds. Biol. Pharm. Bull. 29:1418–1422.
   PubMed Web of Science ®Google Scholar
• Taylor, John B., Triggle,   and David, J. (2006). Comprehensive Medicinal Chemistry–II. Global Perspective, Text Book, Vol. 1. p. 357. Elsevier.
   Google Scholar
• Tepkeeva, I. I., Moiseeva, E. V., Chaadaeva, A. V., Zhavoronkova, E. V., Kessler, Y. V. et al. (2008). Evaluation of antitumor activity of peptide extracts from medicinal plants on the model of transplanted breast cancer in CBRB-Rb (8.17)1Iem mice. Bull. Exp. Biol. Med. 145:464–466.
   PubMed Web of Science ®Google Scholar
• Thakur, A. S., Deshmukh, R., Jha, A. K. and Kumar, P. S. (2014). Synthesis and oral hypoglycemic effect of novel thiazine containing trisubstituted benzenesulfonylurea derivatives. Saudi Pharm. J. 23(5):475–482.
   PubMed Web of Science ®Google Scholar
• Tripathi, S. N., Chandola, H. M., Singh, B. C. and Chadha, A. N. (1990). Study on hypoglycemic fraction of C. tamala and T. belerica. Ayurveda. 11:1–12.
   Google Scholar
• Tuorkey, M. J. and Abdul-Aziz, K. K. (2010). Strategies for diabetes and pathways of vitamin D. diabetes and metabolic syndrome. Clin. Res. Rev. 4(2):101–110.
   Google Scholar
• Udupa, K. N., Tripathi, S. N. and Chandola, H. M. (1980). Effect of C. tamala on plasma insulin vis-à-vis blood sugar in patients of diabetes mellitus. J. Res. Ayurveda Siddha. 1:345–357.
   Google Scholar
• Ueda, H., Howson, J. M., Esposito, L., Heward, J. and Snook, H. (2003). Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature. 423:506–511.
   PubMed Web of Science ®Google Scholar
• Umesha, S., Marahel, S. and Aberomand, M. (2013). Antioxidant and antidiabetic activities of medicinal plants: A short review. Int. J. Pharm. Phytochemical Res. 3(1, Cop):40–53.
   Google Scholar
• Upadhya, S., Shanbhag, K. K., Suneetha, G., Balachandra Naidu, M. and Upadhya, S. (2004). A study of hypoglycemic and antioxidant activity of Aegle marmelos in alloxan induced diabetic rats. Indian J. Physiol. Pharm. 48:476–480.
   PubMedGoogle Scholar
• Vaarala, O., Klemetti, P., Juhela, S., Simell, O., Hyöty, H. and Ilonen, J. (2002). Effect of coincident enterovirus infection and cows' milk exposure on immunisation to insulin in early infancy. Diabetologia 45(4):531–534.
   PubMed Web of Science ®Google Scholar
• Vaarala, O., Knip, M., Paronen, J., Hämäläinen, A. M., Muona, P., Väätäinen, M., Ilonen, J., Simell, O. and Akerblom, H. K. (1999). Cow's milk formula feeding induces primary immunization to insulin in infants at genetic risk for type 1 diabetes. Diabetes. 48:1389–1394.
   PubMed Web of Science ®Google Scholar
• Vadivel, E. and Gopalakrishnan, S. (2011). GC-MS Analysis of some bioactive constituents of Mussaenda frondosa Linn. Inter. J. Pharm. Bio. Sci. 2:313–320.
   Google Scholar
• Vang, T., Congia, M., Macis, M. D., Musumeci, L. and Orru, V. (2005). Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat. Genet. 37:1317–1319.
   PubMed Web of Science ®Google Scholar
• Vashishtha, V. M., John, T. J. and Kumar, A. (2009). Clinical and pathological features of acute toxicitydueto Cassia occidentalis in vertebrates. Indian J. Med. Res. 130:23–30.
   PubMed Web of Science ®Google Scholar
• Vats, V., Yadav, S. P. and Grover, J. K. (2004). Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats. J. Ethnopharm. 90:155–160.
   PubMed Web of Science ®Google Scholar
• Venkatraman, S. and Pari, L. (2003). Effect of Coccinia indica leaves on antioxidant status in streptozotocin-induced diabetic rats. J. Ethnopharm. 84:163–168.
   PubMed Web of Science ®Google Scholar
• Viskari, H. R., Roivainen, M., Reunanen, A., Pitkäniemi, J., Sadeharju, K., Koskela, P. and Hyöty, H. (2002). Maternal first-trimester enterovirus infection and future risk of type 1 diabetes in the exposed fetus. Diabetes 51(8):2568–2571.
   PubMed Web of Science ®Google Scholar
• Vogler, B. K. and Ernst, E. (1999). Aloe vera: a systematic review of its clinical effectiveness. Br. J. Gen. Pract. 49:823–828.
   PubMed Web of Science ®Google Scholar
• Volta, U., Bonazzi, C., Pisi, E., Salardi, S. and Cacciari, E. (1987). Antigliadin and antireticulin antibodies in coeliac disease and at onset of diabetes in children. Lancet. 2:1034–1035.
   PubMed Web of Science ®Google Scholar
• Waheed, A., Minana, G. A. and Ahmad, S. I. (2006). Clinical investigation of hypoglycemic effect of seeds of Azadirachta inidca in type-2 (NIDDM) diabetes mellitus. Pakistan J. Pharm. Sci. 19:322–325.
   PubMedGoogle Scholar
• Xia, T. and Wang, Q. (2006). D-chiro-inositol found in Cucurbita ficifolia (Cucurbitaceae) fruit extracts plays the hypoglycaemic role in streptozocin-diabetic rats. J. Pharm. Pharmacol. 58:1527–1532.
   PubMed Web of Science ®Google Scholar
• Yoon, K. H., Ko, S. H., Cho, J. H., Lee, J. M., Ahn, Y. B., Song, K. H., Yoo, S. J., Kang, M. I., Cha, B. Y., Lee, K. Y. et al. (2003). Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. J. Clin. Endoc. Met. 88:2300–2308.
   PubMed Web of Science ®Google Scholar
• Zaman, K. (1989). Medicinal plants with hypoglycemic activity. J. Ethnopharmacol. 26(1):1–55.
   PubMed Web of Science ®Google Scholar
• Zhang, X. F. and Tan, B. K. (2000). Anti-diabetic property of ethanolic extract of Andrographis paniculata in streptozotocin-diabetic rats. Acta Pharm. Sinica. 21:1157–1164.
   Google Scholar